Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNHD1 DNAH1 DNAH5

8.87e-0518983GO:0008569
GeneOntologyMolecularFunctioncytoskeletal motor activity

DNHD1 MYH13 CENPE DNAH1 DNAH5

2.90e-04118985GO:0003774
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNHD1 DNAH1 DNAH5

3.44e-0428983GO:0051959
GeneOntologyMolecularFunctionmicrotubule motor activity

DNHD1 CENPE DNAH1 DNAH5

3.90e-0470984GO:0003777
DomainDUF1088

NBEA LRBA

2.45e-052932IPR010508
DomainDUF1088

NBEA LRBA

2.45e-052932PF06469
DomainDynein_HC_stalk

DNHD1 DNAH1 DNAH5

4.18e-0514933IPR024743
DomainDynein_heavy_dom-2

DNHD1 DNAH1 DNAH5

4.18e-0514933IPR013602
DomainDHC_N2

DNHD1 DNAH1 DNAH5

4.18e-0514933PF08393
DomainMT

DNHD1 DNAH1 DNAH5

4.18e-0514933PF12777
DomainDHC_fam

DNHD1 DNAH1 DNAH5

5.21e-0515933IPR026983
DomainDynein_heavy

DNHD1 DNAH1 DNAH5

5.21e-0515933PF03028
DomainDynein_heavy_dom

DNHD1 DNAH1 DNAH5

5.21e-0515933IPR004273
DomainSHR-BD

VPS13D VPS13B

1.46e-044932IPR009543
DomainVPS13_C

VPS13D VPS13B

1.46e-044932PF16909
DomainVPS13_C

VPS13D VPS13B

1.46e-044932IPR031645
DomainSHR-BD

VPS13D VPS13B

1.46e-044932PF06650
DomainSortilin_C

SORCS3 SORL1

2.43e-045932PF15901
DomainSortilin-Vps10

SORCS3 SORL1

2.43e-045932PF15902
DomainVPS10

SORCS3 SORL1

2.43e-045932IPR006581
DomainSortilin_N

SORCS3 SORL1

2.43e-045932IPR031778
DomainSortilin_C

SORCS3 SORL1

2.43e-045932IPR031777
DomainVPS10

SORCS3 SORL1

2.43e-045932SM00602
DomainDUF4704

NBEA LRBA

2.43e-045932IPR031570
DomainDUF4704

NBEA LRBA

2.43e-045932PF15787
DomainPH_BEACH

NBEA LRBA

3.63e-046932PF14844
DomainChorein_N

VPS13D VPS13B

6.74e-048932PF12624
DomainPH-BEACH_dom

NBEA LRBA

6.74e-048932IPR023362
DomainVPS13_N

VPS13D VPS13B

6.74e-048932IPR026854
Domain-

NBEA LRBA

6.74e-0489322.30.29.40
DomainPH_BEACH

NBEA LRBA

6.74e-048932PS51783
DomainA2M_N_2

CD109 C5

6.74e-048932SM01359
Domain-

CD109 C5

6.74e-0489322.60.40.690
DomainA2M_recep

CD109 C5

6.74e-048932SM01361
DomainA2M

CD109 C5

6.74e-048932SM01360
DomainBEACH

NBEA LRBA

8.63e-049932PS50197
DomainBeach

NBEA LRBA

8.63e-049932PF02138
Domain-

NBEA LRBA

8.63e-0499321.10.1540.10
DomainBeach

NBEA LRBA

8.63e-049932SM01026
DomainSialidases

SORCS3 SORL1

8.63e-049932IPR011040
DomainBEACH_dom

NBEA LRBA

8.63e-049932IPR000409
DomainCys-rich_flank_reg_C

LRRN1 LRRC38 TLR8 TLR4

1.06e-0390934IPR000483
DomainLRRCT

LRRN1 LRRC38 TLR8 TLR4

1.06e-0390934SM00082
DomainA2M

CD109 C5

1.08e-0310932PF00207
DomainA2M_N_2

CD109 C5

1.08e-0310932IPR011625
DomainA2M_comp

CD109 C5

1.08e-0310932IPR011626
DomainA2M_recep

CD109 C5

1.08e-0310932PF07677
DomainA2M_comp

CD109 C5

1.08e-0310932PF07678
DomainA2M_N

CD109 C5

1.08e-0310932PF01835
DomainA2M_N

CD109 C5

1.08e-0310932IPR002890
DomainA-macroglobulin_rcpt-bd

CD109 C5

1.08e-0310932IPR009048
DomainALPHA_2_MACROGLOBULIN

CD109 C5

1.08e-0310932PS00477
DomainA2M_N_2

CD109 C5

1.08e-0310932PF07703
DomainMacroglobln_a2

CD109 C5

1.08e-0310932IPR001599
Domain-

CD109 C5

1.57e-03129321.50.10.20
DomainDynein_heavy_chain_D4_dom

DNAH1 DNAH5

2.15e-0314932IPR024317
DomainATPase_dyneun-rel_AAA

DNAH1 DNAH5

2.15e-0314932IPR011704
DomainAAA_8

DNAH1 DNAH5

2.15e-0314932PF12780
DomainAAA_5

DNAH1 DNAH5

2.15e-0314932PF07728
DomainIon_trans_dom

MCOLN1 SCN7A TRPV3 CNGA4

2.53e-03114934IPR005821
DomainIon_trans

MCOLN1 SCN7A TRPV3 CNGA4

2.53e-03114934PF00520
DomainP-loop_NTPase

DNHD1 MYH13 CENPE SEPTIN4 ABCA13 RNF213 AK7 DNAH1 CIITA DNAH5 AFG1L

3.24e-038489311IPR027417
DomainLRR

LRRN1 LRRC38 TLR8 CIITA TLR4

3.32e-03201935PS51450
DomainTerpenoid_cyclase/PrenylTrfase

CD109 C5

3.56e-0318932IPR008930
DomainLRR_1

LRRN1 LRRC38 TLR8 CIITA TLR4

4.77e-03219935PF00560
DomainTIR

TLR8 TLR4

4.84e-0321932SM00255
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

DNHD1 CAD MYH13 CENPE PARP1 IGHG1 LRBA DNAH5 VPS13B

2.71e-08234100936243803
Pubmed

BCL8 is a novel, evolutionarily conserved human gene family encoding proteins with presumptive protein kinase A anchoring function.

NBEA NBEAP1 LRBA

2.30e-075100312160729
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

DMXL2 PIGS SREBF2 NBEA ANKRD27 SLC3A2 VPS13D SLC35A2 LRBA PCDH7 VPS13B

2.36e-075041001134432599
Pubmed

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity.

TLR8 SMPDL3A TLR4

4.58e-076100326095358
Pubmed

Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury.

TLR4 C5 C6

1.28e-068100317536017
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

DNHD1 ABCA13 RNF213 PARP1 SLC25A11 DNAH5 SORL1

2.47e-06208100733230847
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

LRRN1 TSHZ2 SREBF2 RNF213 CLASP2 NBEAP1 DNAH1 EVA1C TNRC18 ZNF532 NACC2 CLK2 MICAL2 LRBA VPS13B MTARC1

5.30e-0614891001628611215
Pubmed

Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding domain in complement C6.

C5 C6

8.18e-06210022808363
Pubmed

Induction of IgG3 to LPS via Toll-like receptor 4 co-stimulation.

IGHG1 TLR4

8.18e-062100218946502
Pubmed

A targeted apoB38.9 mutation in mice is associated with reduced hepatic cholesterol synthesis and enhanced lipid peroxidation.

SREBF2 APOB

8.18e-062100216455790
Pubmed

Septin4 as a novel binding partner of PARP1 contributes to oxidative stress induced human umbilical vein endothelial cells injure.

SEPTIN4 PARP1

8.18e-062100229366480
Pubmed

Neutrophils activated by membrane attack complexes increase the permeability of melanoma blood vessels.

C5 C6

8.18e-062100235960843
Pubmed

Landscape of toll-like receptors expression in tumor microenvironment of triple negative breast cancer (TNBC): Distinct roles of TLR4 and TLR8.

TLR8 TLR4

8.18e-062100234022297
Pubmed

Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12.

TEX12 SYCE2

8.18e-062100234373646
Pubmed

C5a and toll-like receptor 4 crosstalk in retinal pigment epithelial cells.

TLR4 C5

8.18e-062100226487798
Pubmed

Involvement of ILR4α and TLR4 in miscarriages.

TLR4 IL4R

8.18e-062100230639993
Pubmed

Ciprofloxacin inhibits lipopolysaccharide-induced toll-like receptor-4 and 8 expression on human monocytes derived from adult and cord blood.

TLR8 TLR4

8.18e-062100217724596
Pubmed

Structural analysis of the human SYCE2-TEX12 complex provides molecular insights into synaptonemal complex assembly.

TEX12 SYCE2

8.18e-062100222870393
Pubmed

Crystal structure of C5b-6 suggests structural basis for priming assembly of the membrane attack complex.

C5 C6

8.18e-062100222500023
Pubmed

Control of RSV-induced lung injury by alternatively activated macrophages is IL-4R alpha-, TLR4-, and IFN-beta-dependent.

TLR4 IL4R

8.18e-062100220404812
Pubmed

Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

RNF213 NBEA ZNF532 MED12L DNAH5

1.13e-05101100510997877
Pubmed

A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells.

CAD CLK4 PARP1 CLK2

1.45e-0551100434316707
Pubmed

Hodgkin disease risk: role of genetic polymorphisms and gene-gene interactions in inflammation pathway genes.

TLR8 TLR4 IL4R

1.82e-0518100321061265
Pubmed

IL-36γ is a crucial proximal component of protective type-1-mediated lung mucosal immunity in Gram-positive and -negative bacterial pneumonia.

TLR4 IL36G

2.45e-053100228176791
Pubmed

The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia.

NBEA LRBA

2.45e-053100228814779
Pubmed

Poly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappa B upon TLR4 stimulation.

PARP1 TLR4

2.45e-053100220610652
Pubmed

Amyloidosis causes downregulation of SorLA, SorCS1 and SorCS3 expression in mice.

SORCS3 SORL1

2.45e-053100231095505
Pubmed

Role of WW domain E3 ubiquitin protein ligase 2 in modulating ubiquitination and Degradation of Septin4 in oxidative stress endothelial injury.

SEPTIN4 PARP1

2.45e-053100231924572
Pubmed

Evaluation of the adjuvant effect of agonists of toll-like receptor 4 and 7/8 in a vaccine against leishmaniasis in BALB/c mice.

TLR8 TLR4

2.45e-053100228963929
Pubmed

Recently reported familial hypercholesterolemia-related mutations from cases in the Middle East and North Africa region.

APOB SORL1

2.45e-053100230694837
Pubmed

Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor.

CLK4 CLK2

2.45e-053100221949414
Pubmed

Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells.

TLR8 TLR4

2.45e-053100219164128
Pubmed

Experimental design of complement component 5a-induced acute lung injury (C5a-ALI): a role of CC-chemokine receptor type 5 during immune activation by anaphylatoxin.

TLR4 C5

2.45e-053100225999468
Pubmed

Formation and structure of the C5b-7 complex of the lytic pathway of complement.

C5 C6

2.45e-05310021387399
Pubmed

Toll-like receptor 4, 7 and 8 polymorphisms have no association with nonmelanoma skin cancer in renal transplant patients.

TLR8 TLR4

2.45e-053100219614650
Pubmed

Human dendritic cells stimulated via TLR7 and/or TLR8 induce the sequential production of Il-10, IFN-gamma, and IL-17A by naive CD4+ T cells.

TLR8 TLR4

2.45e-053100219265114
Pubmed

TLR8 and complement C5 induce cytokine release and thrombin activation in human whole blood challenged with Gram-positive bacteria.

TLR8 C5

2.45e-053100232083344
Pubmed

A high-resolution mass cytometry analysis reveals a delay of cytokines production after TLR4 or TLR7/8 engagements in HIV-1 infected humans.

TLR8 TLR4

2.45e-053100230138900
Pubmed

Toll-Like Receptor mRNA Levels in Schizophrenia: Association With Complement Factors and Cingulate Gyrus Cortical Thinning.

TLR8 TLR4

2.45e-053100238102721
Pubmed

CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment.

CENPE CLASP2

2.45e-053100222307330
Pubmed

Candidate gene polymorphisms for ischemic stroke.

APOB TLR4 C5 IL4R

3.58e-0564100419729601
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

ARHGAP32 APOB SLC3A2 FRMD4A MICAL2 SLC35A2 LRBA PCDH7 VPS13B

4.01e-05569100930639242
Pubmed

A new mechanism for inhalational priming: IL-4 bypasses innate immune signals.

TLR4 IL4R

4.89e-054100218981153
Pubmed

Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis.

C5 C6

4.89e-054100225735751
Pubmed

Association of Toll-like receptor polymorphisms with HIV status in North Americans.

TLR8 TLR4

4.89e-054100225253287
Pubmed

A preliminary study on the association of single nucleotide polymorphisms of interleukin 4 (IL4), IL13, IL4 receptor alpha (IL4Rα) & Toll-like receptor 4 (TLR4) genes with asthma in Indian adults.

TLR4 IL4R

4.89e-054100226831416
Pubmed

Association of Genetic Polymorphisms in TLR3, TLR4, TLR7, and TLR8 with the Clinical Forms of Dengue in Patients from Veracruz, Mexico.

TLR8 TLR4

4.89e-054100233138336
Pubmed

Genetic Susceptibility to Life-threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants.

TLR8 TLR4

4.89e-054100232740454
Pubmed

Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia.

DNAH1 DNAH5

4.89e-054100218492703
Pubmed

The role of redox-dependent mechanisms in the downregulation of ligand-induced Toll-like receptors 7, 8 and 4-mediated HIF-1 alpha prolyl hydroxylation.

TLR8 TLR4

4.89e-054100219841637
Pubmed

Reduced IL-4-, lipopolysaccharide-, and IFN-gamma-induced MHC class II expression in mice lacking class II transactivator due to targeted deletion of the GTP-binding domain.

CIITA TLR4

4.89e-054100210452977
Pubmed

Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint.

CLK4 CLK2

4.89e-054100227126587
Pubmed

Phylogenies of central element proteins reveal the dynamic evolutionary history of the mammalian synaptonemal complex: ancient and recent components.

TEX12 SYCE2

4.89e-054100224026100
Pubmed

Analysis of the human VPS13 gene family.

VPS13D VPS13B

4.89e-054100215498460
Pubmed

Complement activation product C5a is a selective suppressor of TLR4-induced, but not TLR3-induced, production of IL-27(p28) from macrophages.

TLR4 C5

4.89e-054100222491257
Pubmed

High frequency of submicroscopic chromosomal deletions in patients with idiopathic congenital eye malformations.

OTX2 VPS13B

4.89e-054100221353197
Pubmed

Immune-driven alterations in mucin sulphation is an important mediator of Trichuris muris helminth expulsion.

SLC26A1 IL4R

4.89e-054100228192541
Pubmed

Characterization and comparison of four serine- and arginine-rich (SR) protein kinases.

CLK4 CLK2

4.89e-05410029307018
Pubmed

Distribution of centromeric proteins and PARP-1 during mitosis and apoptosis.

CENPE PARP1

4.89e-054100219723035
Pubmed

Chronic filarial infection provides protection against bacterial sepsis by functionally reprogramming macrophages.

TLR4 IL4R

4.89e-054100225611587
Pubmed

Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses.

APBA1 NBEA LRBA

6.42e-0527100319723784
Pubmed

Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.

CAD APOB SLC3A2 PARP1 IGHG1 SLC25A11

7.71e-05244100628902428
Pubmed

The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly.

TEX12 SYCE2

8.14e-055100234969823
Pubmed

Predominant role for C5b-9 in renal ischemia/reperfusion injury.

C5 C6

8.14e-055100210811844
Pubmed

Beacon interacts with cdc2/cdc28-like kinases.

CLK4 CLK2

8.14e-055100212705895
Pubmed

Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.

CLK4 CLK2

8.14e-055100219168442
Pubmed

Expression of murine Lhx5 suggests a role in specifying the forebrain.

OTX2 LHX5

8.14e-05510029022063
Pubmed

TLR agonists downregulate H2-O in CD8alpha- dendritic cells.

TLR8 TLR4

8.14e-055100221918198
Pubmed

TLR2 promotes Th2/Th17 responses via TLR4 and TLR7/8 by abrogating the type I IFN amplification loop.

TLR8 TLR4

8.14e-055100219915052
Pubmed

Involvement of the Toll-Like Receptor/Nitric Oxide Signaling Pathway in the Pathogenesis of Cervical Cancer Caused by High-Risk Human Papillomavirus Infection.

TLR8 TLR4

8.14e-055100228626766
Pubmed

Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and induction of adiponectin in mice.

SREBF2 KLB

8.14e-055100225794851
Pubmed

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.

PIGS UBR4 APOB SLC3A2 CLK2 MICAL2 SLC35A2 SLC25A11

9.97e-05499100822810586
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

CD109 APOB F8 SLC3A2 C5 C6

1.02e-04257100616335952
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

UBR4 NBEA CLASP2 FRMD4A

1.19e-0487100412465718
Pubmed

LRRC59 Regulates Trafficking of Nucleic Acid-Sensing TLRs from the Endoplasmic Reticulum via Association with UNC93B1.

TLR8 TLR4

1.22e-046100226466955
Pubmed

Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection.

TLR8 TLR4

1.22e-046100217301562
Pubmed

An evolutionarily conserved nested gene pair - Mab21 and Lrba/Nbea in metazoan.

NBEA LRBA

1.22e-046100219482073
Pubmed

Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.

C5 C6

1.22e-046100222832194
Pubmed

Estrogen receptor alpha modulates Toll-like receptor signaling in murine lupus.

TLR8 TLR4

1.22e-046100222659029
Pubmed

B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota.

IGHG1 TLR4

1.22e-046100231433298
Pubmed

Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population.

TLR8 TLR4

1.22e-046100217964520
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

ARHGAP32 DMXL2 IQSEC2 NBEA KCNJ10 PCDH7

1.66e-04281100628706196
Pubmed

CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.

C5 C6

1.70e-047100230552328
Pubmed

Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.

DNAH1 DNAH5

1.70e-04710029256245
Pubmed

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.

TLR8 TLR4

1.70e-047100214976262
Pubmed

The heterogeneous allelic repertoire of human toll-like receptor (TLR) genes.

TLR8 TLR4

1.70e-047100219924287
Pubmed

Murine germinal center B cells require functional Fms-like tyrosine kinase 3 signaling for IgG1 class-switch recombination.

IGHG1 IL4R

1.70e-047100226627255
Pubmed

Inhibition of atrogin-1/MAFbx mediated MyoD proteolysis prevents skeletal muscle atrophy in vivo.

MYH13 FBXO32

1.70e-047100219319192
Pubmed

Involvement of the c-jun N-terminal kinases JNK1 and JNK2 in complement-mediated cell death.

C5 C6

1.70e-047100219864026
Pubmed

Multiplex screening of 22 single-nucleotide polymorphisms in 7 Toll-like receptors: an association study in rheumatoid arthritis.

TLR8 TLR4

1.70e-047100220194452
Pubmed

Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration.

MCOLN1 TLR8

1.70e-047100226115100
Pubmed

Differential contribution of C5aR and C5b-9 pathways to renal thrombic microangiopathy and macrovascular thrombosis in mice carrying an atypical hemolytic syndrome-related factor H mutation.

C5 C6

1.70e-047100230910380
Pubmed

The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4.

TLR4 C5

1.70e-047100216301658
Pubmed

BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.

DMXL2 NBEA ANKRD27 SLC3A2 AGFG1 LRBA

1.80e-04285100634369648
Pubmed

The N-reductive system composed of mitochondrial amidoxime reducing component (mARC), cytochrome b5 (CYB5B) and cytochrome b5 reductase (CYB5R) is regulated by fasting and high fat diet in mice.

MCOLN1 MTARC1

2.27e-048100225144769
Pubmed

Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.

TLR8 TLR4

2.27e-048100212724322
Pubmed

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining.

IGHG1 MSLN

2.27e-048100225798939
Pubmed

Molecular organization and function of the complement system.

C5 C6

2.27e-04810023052276
Pubmed

A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility.

TEX12 SYCE2

2.27e-048100221637789
Pubmed

TLR costimulation causes oxidative stress with unbalance of proinflammatory and anti-inflammatory cytokine production.

TLR8 TLR4

2.27e-048100224771848
GeneFamilyCDC like kinases

CLK4 CLK2

7.84e-054662480
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

CD109 C5

4.65e-0496621234
GeneFamilyWD repeat domain containing|BEACH domain containing

NBEA LRBA

4.65e-0496621230
GeneFamilyCD molecules|Toll like receptors

TLR8 TLR4

5.80e-0410662948
GeneFamilyDyneins, axonemal

DNAH1 DNAH5

1.72e-0317662536
GeneFamilyApolipoproteins

APOB APOL6

2.64e-0321662405
GeneFamilyTransient receptor potential cation channels

MCOLN1 TRPV3

4.67e-0328662249
ToppCellCOVID-19_Severe-Classical_Monocyte|World / disease group, cell group and cell class

TFEC DMXL2 TLR8 NACC2 TLR4 AGFG1 MTARC1

3.15e-071971007344801997b89bd81d8d5c3c872934de523233a8d
ToppCellPBMC-Control-cDC_0|Control / Compartment, Disease Groups and Clusters

DMXL2 UBR4 NACC2 SMPDL3A TLR4 APOL6 SORL1

3.37e-071991007ebf03979ef56e978d72db475bb635b43b9cbe402
ToppCellsevere-CD163+_Monocytes_(Sample_ID1_d7)|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TFEC DMXL2 TLR8 NACC2 SMPDL3A TLR4 MTARC1

3.48e-072001007a3f22826f3d8f917ff0594bdadd93b60763bcaa2
ToppCellsevere-CD163+_Monocytes_(Sample_ID1_d7)|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TFEC DMXL2 TLR8 NACC2 SMPDL3A TLR4 MTARC1

3.48e-0720010074943fe826d5fcc3dfeb8b99a7415848f3fecc994
ToppCellHealthy_Control-Lymphoid-Plasma|Healthy_Control / Condition, Lineage, Cell class and cell subclass

DNHD1 TSHZ2 SREBF2 EVA1C IGHG1 MICAL2

1.85e-0616310062913ccdd4613472cd82077d4993e1d9f8b223398
ToppCellHealthy_Control-Lymphoid-Plasma-|Healthy_Control / Condition, Lineage, Cell class and cell subclass

DNHD1 TSHZ2 SREBF2 EVA1C IGHG1 MICAL2

1.85e-061631006b589ff57d58dcb215ee3b5a10d81f43e5752a196
ToppCellCOVID-19-kidney-PEC|kidney / Disease (COVID-19 only), tissue and cell type

TTC28 TSHZ2 APBA1 EVA1C FRMD4A MSLN

2.53e-06172100636a96714a0eb6ac438648135336c9791881ddadb
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SMG1 ARHGAP32 TSHZ2 ABCA13 NBEA SORL1

3.19e-0617910066e965e424eebef50f0202cff75f458be395cfca1
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA3A AK7 DNAH1 LRRC9 EVA1C DNAH5

3.74e-061841006264e14aa1859cfc0ed5fb40e97ea189aed9ef4a5
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA3A AK7 DNAH1 LRRC9 EVA1C DNAH5

3.74e-061841006d7eccbd21c480d907fdc8eff2bf5ae22ae452221
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA3A AK7 DNAH1 LRRC9 EVA1C DNAH5

3.74e-06184100622010cfe0428ebfa40952cc1a1a12ad3d25b35c9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

VWA3A TSHZ2 APBA1 EVA1C FRMD4A MICAL2

3.85e-06185100634fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

VWA3A TSHZ2 APBA1 EVA1C FRMD4A MICAL2

3.85e-0618510068816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCellhuman_hepatoblastoma-Inflammatory_Monocytes|World / Sample and Cell Type and Tumor Cluster (all cells)

TFEC DMXL2 CD109 APBA1 MCOLN1 CIITA

4.63e-0619110063b59bfc6c106ae8a3fbcd4a74bd128c485724921
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

TSHZ2 APBA1 FIBIN SMPDL3A SCN7A PCDH7

4.63e-061911006fa380a8752de158974b2ae5e741573439719cc0d
ToppCellRV-08._Macrophage|World / Chamber and Cluster_Paper

TFEC DMXL2 CENPE RNF213 TLR4 AGFG1

4.77e-061921006a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

TFEC DMXL2 TLR8 NACC2 SMPDL3A TLR4

4.92e-061931006d845beb0915a5b4bbd1e8f9b8d9322527a822849
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VWA3A ABCA13 COL28A1 NBEA AK7 DNAH5

5.06e-0619410064a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TFEC DMXL2 MCOLN1 TLR8 CIITA TLR4

5.37e-0619610065fe6534af65d43eeacd4b031310242b4f706008b
ToppCellBL|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

RNF213 TLR8 TLR4 APOL6 IL4R SORL1

5.53e-0619710061acf0191fa0a25cd20bfd9ea7bf727a1555986a1
ToppCellnucseq-Immune-Immune_Myeloid-IM|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TFEC DMXL2 CD109 FRMD4A CIITA SMPDL3A

5.53e-0619710066f41c8f815851968849428ec92c16745bd01a3fb
ToppCellnucseq-Immune-Immune_Myeloid-IM-IM|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TFEC DMXL2 CD109 FRMD4A CIITA SMPDL3A

5.53e-061971006304044ace926943b8eb588f686ecbe5d1689a809
ToppCellCOVID-19_Severe-Classical_Monocyte|COVID-19_Severe / disease group, cell group and cell class

TFEC DMXL2 TLR8 TLR4 AGFG1 MTARC1

5.69e-061981006b88c4c0ed1abf0a28dbe05b04b9bee1073855ba8
ToppCellsevere-HLA-DR+_CD83+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DMXL2 CD109 MICAL2 TLR4 AGFG1 SORL1

5.69e-061981006d5e525d2f2226d06a3fb985ce3a33555ff4b2e7b
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VWA3A ARHGAP32 TSHZ2 ABCA13 NBEA DNAH5

5.69e-061981006d0ecace1fad24ce50b0935036fabb07e6c9e372d
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

ARHGAP32 TTC28 NBEA CLASP2 LRBA VPS13B

5.86e-06199100694b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellBronchus_Control_(B.)-Epithelial-TX|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

TSHZ2 ABCA13 NBEA FAM3D EVA1C DNAH5

6.03e-062001006f5bc7d30aa03dd0f95eb64255bd1a2543be8d327
ToppCellcontrol-Neutrophil|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TFEC DMXL2 UBR4 TLR8 TNRC18 TLR4

6.03e-062001006b5d197472799cc61d7497faed91ac2564ae4930a
ToppCellcontrol-HLA-DR-_S100A+_Monocyte|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TFEC DMXL2 TNRC18 TLR4 AGFG1 MTARC1

6.03e-0620010069e3e13a68bc1110fa000ec2d80f4c654ddbce17e
ToppCell343B-Lymphocytic-NK_cells-NK_cell_D|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

DMXL2 CAD TSHZ2 ZNF541

1.49e-0566100457fd31a25addc48793d7975eadccf4c5a41a8b03
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Neurod2-Excitatory_Neuron.Slc17a7.Neurod2-Rorb_(Nucleus_of_the_lateral_olfactory_tract_(LOT))-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CIITA APOL6 ZNF541 KLB

1.68e-056810046945089858778301a05ecc5895310d768768758c
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Neurod2-Excitatory_Neuron.Slc17a7.Neurod2-Rorb_(Nucleus_of_the_lateral_olfactory_tract_(LOT))|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CIITA APOL6 ZNF541 KLB

1.68e-05681004ac9d0f473c878b96a422bbdd7088eb8125574dde
ToppCell10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

VWA3A ABCA13 COL28A1 C6 LRBA

2.71e-05156100510d191e29b16cae8238e8df6c0ff38882253f34e
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAM3D DNAH1 LRRC9 DNAH5 MSLN

3.45e-051641005e4d4c59aebe5cacd4ecdb907facd044dc82a831d
ToppCellAdult-Epithelial-lung_goblet_cell-D175|Adult / Lineage, Cell type, age group and donor

LRRN1 TSHZ2 ABCA13 FAM3D PCDH7

3.45e-0516410056e6aedb61f8e195d52e028fdda750a29bb14e57e
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRRN1 CENPE IQSEC2 C5 PCDH7

3.65e-05166100543f84d3cd58e93ce00c241656c4cba27604b4932
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 DNAH1 SORCS3 C6 DNAH5

3.98e-05169100512bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Mesenchymal-ependymal_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AK7 DNAH1 LRRC9 SCN7A MTARC1

4.09e-051701005b535baeb4dbd644051cf992babb61add9eaae4e3
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Mesenchymal-Ependyma|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AK7 DNAH1 LRRC9 SCN7A MTARC1

4.09e-0517010052477c9f29dbe27f172df699003971e828d6ab8c9
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-10|TCGA-Brain / Sample_Type by Project: Shred V9

CD109 AK7 LRRC9 C6 DNAH5

4.21e-05171100574be8d3bf6b99e2d734635a8b1a7c41e8c596959
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RNF213 FRMD4A CIITA TLR4 APOL6

4.57e-051741005d5c22b43531414951666ee7542a66ed9380e2d14
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TFEC CD109 APBA1 KCNJ10 C6

4.82e-0517610055e46a09a36b9645b1b1fcb0b64bd0898561af3a9
ToppCelldroplet-Lung-LUNG-30m-Epithelial-club_cell_of_bronchiole|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AK7 DNAH1 FHDC1 DNAH5 MSLN

4.96e-0517710057ac99ff16df94b4e08d361e3d98a7b3af8d6ee3b
ToppCelldroplet-Lung-LUNG-30m-Epithelial-Club_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AK7 DNAH1 FHDC1 DNAH5 MSLN

4.96e-051771005092a345cb802f183322aa5542341ba2d96d4f06a
ToppCelldroplet-Liver-nan-3m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP32 TTC28 TSHZ2 F8 EVA1C

5.51e-051811005fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Ciliated|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

VWA3A AK7 C6 DNAH5 CNGA4

5.51e-0518110058eed9d46d924b16f6dd1a025ff612244b02b4391
ToppCellControl-Epithelial_cells-Airway_ciliated|Control / group, cell type (main and fine annotations)

VWA3A ABCA13 AK7 C6 DNAH5

5.66e-051821005fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ2 EVA1C IGHG1 MICAL2 IL4R

5.96e-051841005d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCellLPS_only|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RNF213 EVA1C APOL6 IL4R VPS13B

6.11e-051851005a72ccb147ca505880e2da8f6a70b9d570464a691
ToppCelldroplet-Lung-nan-18m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA3A AK7 DNAH1 FHDC1 DNAH5

6.27e-051861005740fd06bcd3b24e6ff2ecf8080f378afc3e95084
ToppCelldroplet-Lung-nan-18m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA3A AK7 DNAH1 FHDC1 DNAH5

6.27e-0518610055ab43a298d23238b34e898d11decf0ad81d1b14e
ToppCellCOPD-Epithelial-Ciliated|COPD / Disease state, Lineage and Cell class

VWA3A ABCA13 AK7 C6 DNAH5

6.43e-051871005f0fd0792f6926f705d175f6e6fd480f12c7a3bd4
ToppCell3'_v3-blood|World / Manually curated celltypes from each tissue

TSHZ2 NACC2 AGFG1 MTARC1 SORL1

6.43e-0518710059e70e8d7cd8ae517ddf5fd56c69ec16fc33ddff5
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

VWA3A TSHZ2 APBA1 EVA1C FRMD4A

6.59e-051881005b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

VWA3A TSHZ2 APBA1 EVA1C FRMD4A

6.59e-051881005874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

TTC28 ABCA13 C5 FHDC1 DNAH5

6.59e-051881005ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCelldroplet-Lung-18m-Epithelial-airway_epithelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWA3A AK7 DNAH1 FHDC1 DNAH5

6.76e-051891005fe958fdf9963c2dfe270f67f0da36b3264d0017c
ToppCellAdult|World / Lineage, Cell type, age group and donor

DMXL2 SREBF2 RNF213 CIITA DNAH5

6.76e-0518910055cd285bfad973125d46d704fec18b21266a63379
ToppCellCOVID-19-lung-Ciliated|lung / Disease (COVID-19 only), tissue and cell type

VWA3A ABCA13 AK7 C6 DNAH5

6.76e-05189100527329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCellCOPD-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

VWA3A ABCA13 AK7 C6 DNAH5

6.76e-0518910053e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCellControl-Myeloid|Control / group, cell type (main and fine annotations)

TFEC DMXL2 FRMD4A CIITA TLR4

7.11e-0519110059c4acc5f3c2f9c0c5520863bb22f391774372347
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

VWA3A ABCA13 AK7 C6 DNAH5

7.11e-051911005e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

VWA3A ABCA13 AK7 C6 DNAH5

7.11e-0519110059d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCellCOVID-19-lung-Macrophage_PPARGhi_CD5Lhi|lung / Disease (COVID-19 only), tissue and cell type

TFEC DMXL2 MCOLN1 FRMD4A CIITA

7.11e-051911005dab953682b8c9ed680a799161f837f792a7e4f33
ToppCellwk_15-18-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

VWA3A ABCA13 AK7 C6 DNAH5

7.11e-051911005e81cd65dbf0ef1c2ab7088f73ce605d456dd3a7a
ToppCelldroplet-Lung-18m-Epithelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MYH13 AK7 DNAH1 FHDC1 C6

7.11e-0519110051b59f1cad6c1a6a5938afa9195164918e3ff4e86
ToppCellPND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWA3A FAM3D AK7 DNAH1 DNAH5

7.11e-05191100596483adb97c81208aa513782550acd8a08b63866
ToppCellnucseq-Epithelial-Epithelial_Airway|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

VWA3A ABCA13 AK7 C6 DNAH5

7.11e-0519110051c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCellCOVID-19-lung-Macrophage_PPARGhi_CD5Lhi|COVID-19 / Disease (COVID-19 only), tissue and cell type

TFEC DMXL2 MCOLN1 FRMD4A CIITA

7.28e-051921005bcfb9c005166bc0b4f8ee2dfc0c1540e8bf0e1ff
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RNF213 APOB TLR4 MED12L SORL1

7.28e-051921005935a4a36881a9fa4daa02cba96af07f6686ed8d6
ToppCellEnterocyte_Progenitors-C_06|Enterocyte_Progenitors / shred on cell type and cluster

TSHZ2 FAM3D IGHG1 TLR4 PCDH7

7.28e-051921005b9938e1a929c00628cc6ebfdf10cf285167f445c
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

SMG1 TSHZ2 RNF213 CLASP2 SORL1

7.28e-05192100547646d7e4990be85072987f92bf18d52f8da752e
ToppCellCOPD-Epithelial-Ciliated|World / Disease state, Lineage and Cell class

VWA3A ABCA13 AK7 C6 DNAH5

7.28e-051921005eab1105cd1a98cfcd3d74dc5c9b89e1799bba59e
ToppCellControl-Myeloid-Monocyte-derived_macrophages|Control / group, cell type (main and fine annotations)

TFEC DMXL2 APBA1 FRMD4A CIITA

7.46e-051931005a6b3bd01e585e2e3fbe9bf693a2e385773123f8e
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

VWA3A TSHZ2 ABCA13 DNAH5 PCDH7

7.46e-051931005ea345d34440b25f65358a53dc72831998d1c3620
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SMG1 TSHZ2 RNF213 LRBA VPS13B

7.46e-0519310059337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA3A SEPTIN4 NBEA F8 PCDH7

7.46e-0519310052483bb7f398e4fa0ef09c8bd584ed25703853f03
ToppCellASK440-Epithelial-Ciliated|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

VWA3A ABCA13 AK7 C6 DNAH5

7.46e-051931005a0baa8be6f590b2031fede22be588715ae458e93
ToppCellwk_20-22-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

VWA3A ABCA13 COL28A1 AK7 DNAH5

7.65e-051941005756082a0f5953b52229bb60d40b84701cb6cb23d
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TTC28 TSHZ2 FRMD4A SCN7A PCDH7

7.65e-051941005011e14d9ed1393275f892060e7708ffadcd0767f
ToppCellC_06|World / shred on cell type and cluster

TSHZ2 FAM3D IGHG1 TLR4 PCDH7

7.65e-0519410055cb42e09f380c4468cdc603ec0c3de35eadd3213
ToppCellControl-Classical_Monocyte|Control / Disease condition and Cell class

TFEC DMXL2 MICAL2 MTARC1 SORL1

7.65e-0519410059e33e1b54b4114f9e6981819834bb796ed7192b5
ToppCellMonocytes-C1QA+_Monocytes|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

TFEC DMXL2 TLR8 FRMD4A TLR4

7.65e-0519410053e104e85574894c04791252d466d438fc809dde3
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

VWA3A NBEA AK7 EVA1C DNAH5

7.83e-051951005fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic-classical_monocyte|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

DMXL2 TLR8 NACC2 TLR4 MTARC1

7.83e-051951005f8908657db50f1c58904dd6fee4fc23f5ae3eed6
ToppCellCOVID-19-Myeloid-Monocyte-derived_macrophages|COVID-19 / group, cell type (main and fine annotations)

TFEC DMXL2 FRMD4A CIITA TLR4

7.83e-051951005c172c5599379c29123340621a36bfb1fc90c2115
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

VWA3A NBEA AK7 EVA1C DNAH5

7.83e-051951005eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Myeloid-MMP9+_Inflammatory_macrophage|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TFEC DMXL2 TLR8 KCNJ10 TLR4

7.83e-0519510055a7c74f96f213c504abd65e751800da7e03e47d9
ToppCellMonocytes|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

TFEC DMXL2 TLR8 FRMD4A TLR4

8.03e-051961005ab0a8f5f388c9794d7f41f99fb0a5f2fd6fff6b3
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LRRN1 TSHZ2 ABCA13 DNAH5 PCDH7

8.03e-051961005b07db4a53ab9be9aad6fae5e45f9547db829d096
ToppCellMonocytes-IL1B+_Monocytes|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

TFEC DMXL2 TLR8 FRMD4A TLR4

8.03e-0519610057bc0735d324ac5a1661434cda4116ddd58296730
ToppCellcritical-Epithelial-Secretory|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

LRRN1 TSHZ2 FAM3D MSLN SORL1

8.03e-051961005dbf14f5851c2b779a8b35e820c4584ea9096e49d
ToppCell(7)_Macrophage|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

PGA5 MCOLN1 FRMD4A SMPDL3A KCNJ10

8.03e-051961005f1c822860d2a0bae84b0263b0151185756423e0f
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Macrophages|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DMXL2 RNF213 FRMD4A CIITA TLR4

8.22e-05197100510190b877bf46ba2163d203df9dd3b498c66e52f
ToppCellsevere-unassigned|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LRRN1 CENPE ABCA13 MED12L TRPV3

8.22e-05197100570704b149b2820b8601d2495b7cd9cbe91eda262
ToppCellsaliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRRN1 NBEA PARP1 PCDH7 MSLN

8.22e-051971005d6c9da7a3a6d2bcb13e2fc6605c8a59e7fb121c5
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_monocytic-monocyte|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TFEC DMXL2 TLR8 TLR4 MTARC1

8.22e-051971005ec46aa307ce5774b4c0fcba64514f2d0cab3c4f9
ToppCell10x_3'_v3-blood_(10x_3'_v3)|10x_3'_v3 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TLR8 NACC2 MICAL2 TLR4 MTARC1

8.22e-0519710052d3547107c88c7443fc6425742694e13368a71f5
ToppCellsaliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRRN1 NBEA PARP1 PCDH7 MSLN

8.22e-05197100580b05c8ad9c1edc5dea3236079372475431343fe
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Macrophages|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TFEC DMXL2 TLR8 FRMD4A CIITA

8.22e-051971005e698a0bbb20bd4868ff4348f2ac9f609942b55fa
DiseaseMalignant neoplasm of breast

PIGS UBR4 CD109 SREBF2 MCOLN1 PARP1 ZNF532 SLC35A2 LRBA VPS13B ZNF541 SORL1

1.91e-0410749612C0006142
Diseasehelix rolling

LRBA CCNYL2

2.90e-048962EFO_0007670
Diseasecommon bile duct neoplasm (is_marker_for)

APOB MSLN

2.90e-048962DOID:4608 (is_marker_for)
Diseasearthritis (is_implicated_in)

PARP1 TLR4

3.72e-049962DOID:848 (is_implicated_in)
Diseaselevel of Diacylglycerol (18:1_18:1) in blood serum

APOB MTARC1

5.65e-0411962OBA_2045170
Diseaseneuroblastoma

MYH13 EVA1C FBXO32 DNAH5

5.70e-04116964EFO_0000621
Diseasetype 2 diabetes mellitus (is_marker_for)

APOB F8 PARP1 TLR4

1.03e-03136964DOID:9352 (is_marker_for)
Diseaseperinatal necrotizing enterocolitis (biomarker_via_orthology)

PARP1 TLR4

1.38e-0317962DOID:8677 (biomarker_via_orthology)
DiseaseHypercholesterolemia, Familial

SREBF2 APOB

1.55e-0318962C0020445
Diseasekidney failure (biomarker_via_orthology)

PARP1 TLR4

1.73e-0319962DOID:1074 (biomarker_via_orthology)
Diseaseasthma (is_implicated_in)

PARP1 TLR4 C5 IL4R

1.75e-03157964DOID:2841 (is_implicated_in)
Diseasepsychotic symptoms

TSHZ2 COL28A1 FBXO32

1.83e-0374963EFO_0005940
DiseaseColorectal Carcinoma

TFEC CAD ABCA13 CD109 APOB PARP1 TLR4 SORL1

2.08e-03702968C0009402
Diseasecarotid artery disease (is_implicated_in)

SREBF2 TLR4

2.32e-0322962DOID:3407 (is_implicated_in)
Diseasecognitive function measurement

DMXL2 TTC28 APBA1 NBEA FPGT FRMD4A MED12L SORCS3 FHDC1 DNAH5 PCDH7 AFG1L

2.38e-0314349612EFO_0008354
DiseaseBehcet Syndrome

APOB TLR4

2.76e-0324962C0004943
Diseaseuveitis (biomarker_via_orthology)

KCNJ10 TLR4

2.99e-0325962DOID:13141 (biomarker_via_orthology)
Diseaseanogenital venereal wart (is_marker_for)

TLR8 TLR4

3.24e-0326962DOID:11168 (is_marker_for)
Diseaseblood rubidium measurement

ABCA13 FRMD4A

3.24e-0326962EFO_0021529
Diseaseatopic dermatitis (is_implicated_in)

TLR4 IL4R

3.24e-0326962DOID:3310 (is_implicated_in)
Diseaseresponse to norepinephrine-dopamine reuptake inhibitor

AK7 FBXO32

3.24e-0326962EFO_0007870

Protein segments in the cluster

PeptideGeneStartEntry
SAKEAISEGYFSSLS

FAM228B

286

P0C875
SLKGDADLYVSASSL

C6orf120

71

Q7Z4R8
YGSFASKLSEDLNTI

AZIN1

321

O14977
SAFSLGYDLATLSKE

APOL6

241

Q9BWW8
SLSKADALFELSGFS

CIITA

556

P33076
LGLSTFDFLKDNNYL

CLK2

246

P49760
LGASDYLELSKNFDT

AFG1L

356

Q8WV93
QAFLKDSSGSELTYT

ABCA13

4101

Q86UQ4
VDSNLFVYSKSDALL

DMXL2

1141

Q8TDJ6
KDSGTFILSDYSNLQ

DNHD1

1201

Q96M86
YSASQLKGFSLLATE

PARP1

176

P09874
SLSGLQKSFTLVELY

LRRC9

991

Q6ZRR7
SDDLTLLESSSSYKN

MCOLN1

206

Q9GZU1
DLFSVYLSADDKSGS

PGA5

211

P0DJD9
SSLAKDELGYCLTSF

ANKRD27

341

Q96NW4
DVSKLSLADSFLYGL

FHDC1

231

Q9C0D6
LFSDLGSSYAKQLGF

FAM3D

161

Q96BQ1
GDLNSFEFKSLTDSL

LIN9

481

Q5TKA1
EAELLLKSSSLAGSY

MED12L

861

Q86YW9
GDTLTLSAAYTKDLL

MTARC1

121

Q5VT66
SLSASGKYIADFSLF

KCNJ10

316

P78508
SYFQLLDSLTKASGL

JMJD7

301

P0C870
ESLYGLAKQFTILDS

SMPDL3A

386

Q92484
SKALSDSYELSTDLQ

IQSEC2

316

Q5JU85
FYSAAKNGSLSADDL

CCNYL2

336

Q5T2Q4
FSLESGSEYLKIDNL

PCDH7

66

O60245
LLLYDGKLSSAIAFT

LRBA

406

P50851
KDDYLSSSSLKEGSL

LHX5

116

Q9H2C1
GQLDKDTLDTLTAFY

MSLN

431

Q13421
GLSLSDLQEAKYETF

F8

821

P00451
SGSAKLVFLDLSYNN

LRRC38

101

Q5VT99
ASGFSLSLEIVKNYS

OVOS2

1311

Q6IE36
LYNSIFSLLSFEKIG

CYHR1

216

Q6ZMK1
EDNLSSSYSAVALDK

ARHGAP32

1081

A7KAX9
KQFLLDSGYFSDNIL

SLC25A11

206

Q02978
LASYILQEAKGDFSS

FRMD4A

141

Q9P2Q2
ANLLKSYSSLGEDFL

DNAH1

3791

Q9P2D7
ISALTDFSGYLTKLL

EVA1C

46

P58658
GLSLDFSSKLDNIYS

APOB

1761

P04114
EDSSELQLKAYFLGS

CD109

436

Q6YHK3
LTSELGKSYNTAFEL

IL36G

151

Q9NZH8
AGYKAFSSLLASSAV

IL4R

601

P24394
SLEYDIKLAALQFSS

COL28A1

86

Q2UY09
DLLYQFSSEELKNSG

C6

376

P13671
FTLAISAYALSLGDK

C5

1186

P01031
KDLLLTSSYLSDSGS

SLC3A2

396

P08195
FAANYLGSTQLLSDK

APBA1

461

Q02410
TASLGTYLKTNLFLF

G6PC2

201

Q9NQR9
GSSDSYIFLEKDLSA

KLB

126

Q86Z14
LDSDGSFFLYSKLTV

IGHG1

281

P01857
LLGLSTYDFIKENSF

CLK4

241

Q9HAZ1
LDEKSGSFVSDLSSY

FBXO32

26

Q969P5
LEQFLSFAKYLDGLS

NBEAP1

16

P0C6P0
IGDAYSNSDKSLTEL

FIBIN

126

Q8TAL6
KFDSSLGALKTELSY

CENPE

856

Q02224
YFTSDNSLKSELGLQ

FPGT

381

O14772
ALYTADLKFALTAET

DNAH5

1196

Q8TE73
VGLDSLESLSFYDNK

LRRN1

236

Q6UXK5
YGENADLSLAKSSIS

MICAL2

636

O94851
SSLGFNSTTDCLDYK

OTX2

246

P32243
LKSSLGYEITFSLLN

PIGS

221

Q96S52
NLYISEAEGLKFSLS

SORL1

371

Q92673
KLDAFSSADLESAYG

SCRT1

11

Q9BWW7
GKSTLVNSLFLTDLY

SEPTIN4

156

O43236
KLYDFNLGSVTESSL

SORCS3

216

Q9UPU3
LEQFLSFAKYLDGLS

NBEA

571

Q8NFP9
ADFNYIKSLSSFESG

SMG1

1226

Q96Q15
LTGAYLLTLKDTFFD

POLR3A

546

O14802
SGLYFSSLDSSIDIL

SYCE2

56

Q6PIF2
YADNILKGFATSLSI

SLC35A2

291

P78381
QSSASSDKYAALAEL

AGFG1

366

P52594
SLSQSKEDLYLDSLS

CEP164

1081

Q9UPV0
SLGYSDLFCLSKEDL

CNGA4

436

Q8IV77
NAGSYASLEDTSDKL

CLASP2

401

O75122
TSILQGFSYSDLRKF

RNF213

1011

Q63HN8
SSKSLLTSDDYELGA

TNRC18

1556

O15417
AYGKALDLSLNSIFF

TLR8

481

Q9NR97
NGFLTASSLDSYSKD

ZNF532

91

Q9HCE3
KDFFLQSLYSLTGLD

SLC26A1

551

Q9H2B4
KLGFLASYFLSRAQS

SREBF2

731

Q12772
TSDISKNSESGYILF

USP12

351

O75317
LKLLSFLFSNYAGAE

MYH13

616

Q9UKX3
ASSLFQTSEGKYLLS

TSHZ2

861

Q9NRE2
SAAGLKLYLNETFSE

CAD

1551

P27708
AFYSSLLNGLKASAA

TTC28

1671

Q96AY4
LSTKGFTYLTNSLFD

VPS13B

486

Q7Z7G8
GYNFEKSLLLTSSLV

ZNF502

101

Q8TBZ5
SYGSFSDAVLELFKL

TRPV3

621

Q8NET8
QYIDSSKLSDFAAAL

SCN7A

1531

Q01118
LSYFTDLSFSAALKE

TFEC

286

O14948
YALKSLTGLLSSFVE

UBR4

4236

Q5T4S7
AFSDLEALSLSTLYS

UNK

731

Q9C0B0
ELDLQKFSSSASYTG

EDA2R

256

Q9HAV5
FGTTSLKYLDLSFNG

TLR4

396

O00206
AETSLLLFYTEKGND

VWA3A

816

A6NCI4
SDSSFSEISGLFYKD

TEX12

36

Q9BXU0
NLDTLSLYSGKDSDS

ZNF541

71

Q9H0D2
YTFSLATDLNSRKDG

UBASH3A

351

P57075
LLKLLSFFGYDQAES

VPS13D

3946

Q5THJ4
FINLLDSYSSGNIGK

AK7

21

Q96M32
SSLYFRDLFSGNSKS

NACC2

51

Q96BF6