Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP hydrolysis activity	DMC1 SPG7 ATAD1 CLU DDX54 MCM2 DNA2 DNAH5 DNAH6 HELB	3.25e-05	441	91	10	GO:0016887
GeneOntologyMolecularFunction	ATP-dependent activity	DMC1 SPG7 ATAD1 CLU RAD54B DDX54 MCM2 DNA2 DNAH5 DNAH6 HELB	1.08e-04	614	91	11	GO:0140657
GeneOntologyMolecularFunction	single-stranded DNA helicase activity	MCM2 DNA2 HELB	1.52e-04	23	91	3	GO:0017116
GeneOntologyMolecularFunction	DNA helicase activity	RAD54B MCM2 DNA2 HELB	1.84e-04	62	91	4	GO:0003678
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	DMC1 RAD54B MCM2 DNA2 HELB	2.89e-04	127	91	5	GO:0008094
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	TBC1D9B DENND6A GBF1 TRIO TBC1D12 RIMS1 OCRL PREX1 ARHGEF10L	5.06e-04	507	91	9	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	TBC1D9B DENND6A GBF1 TRIO TBC1D12 RIMS1 OCRL PREX1 ARHGEF10L	5.06e-04	507	91	9	GO:0030695
GeneOntologyMolecularFunction	helicase activity	RAD54B DDX54 MCM2 DNA2 HELB	7.83e-04	158	91	5	GO:0004386
GeneOntologyMolecularFunction	5'-3' DNA helicase activity	DNA2 HELB	1.10e-03	11	91	2	GO:0043139
Domain	-	DMC1 NLRP9 SPG7 ATAD1 RAD54B DDX54 MCM2 DNA2 DNAH5 DNAH6 NLRP4 HELB	2.13e-04	746	89	12	3.40.50.300
Domain	ARM-type_fold	GBF1 PSME4 UTP20 RIPOR1 NBEA PRKDC RYR3 KPNA1	2.14e-04	339	89	8	IPR016024
Domain	AAA+_ATPase	DMC1 SPG7 ATAD1 DNAH5 DNAH6	6.27e-04	144	89	5	IPR003593
Domain	AAA	DMC1 SPG7 ATAD1 DNAH5 DNAH6	6.27e-04	144	89	5	SM00382
Domain	P-loop_NTPase	DMC1 NLRP9 SPG7 ATAD1 RAD54B DDX54 MCM2 DNA2 DNAH5 DNAH6 NLRP4 HELB	6.76e-04	848	89	12	IPR027417
Domain	ARM-like	PSME4 UTP20 RIPOR1 NBEA PRKDC KPNA1	1.84e-03	270	89	6	IPR011989
Domain	Na_H_Exchanger	TMCO3 SLC9A6	1.97e-03	14	89	2	PF00999
Domain	Dynein_heavy_chain_D4_dom	DNAH5 DNAH6	1.97e-03	14	89	2	IPR024317
Domain	Dynein_HC_stalk	DNAH5 DNAH6	1.97e-03	14	89	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH5 DNAH6	1.97e-03	14	89	2	IPR013602
Domain	DHC_N2	DNAH5 DNAH6	1.97e-03	14	89	2	PF08393
Domain	MT	DNAH5 DNAH6	1.97e-03	14	89	2	PF12777
Domain	Cation/H_exchanger	TMCO3 SLC9A6	1.97e-03	14	89	2	IPR006153
Domain	AAA_8	DNAH5 DNAH6	1.97e-03	14	89	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH5 DNAH6	1.97e-03	14	89	2	IPR011704
Domain	AAA_5	DNAH5 DNAH6	1.97e-03	14	89	2	PF07728
Domain	DHC_fam	DNAH5 DNAH6	2.26e-03	15	89	2	IPR026983
Domain	Dynein_heavy_dom	DNAH5 DNAH6	2.26e-03	15	89	2	IPR004273
Domain	Dynein_heavy	DNAH5 DNAH6	2.26e-03	15	89	2	PF03028
Domain	GRAM	TBC1D9B MTMR1	2.58e-03	16	89	2	SM00568
Domain	DH_1	TRIO PREX1 ARHGEF10L	3.38e-03	63	89	3	PS00741
Domain	C2	SYT11 CAPN6 RIMS1 DYSF	3.56e-03	131	89	4	PF00168
Domain	PRAME_family	PRAMEF10 PRAMEF17	3.64e-03	19	89	2	IPR026271
Domain	ConA-like_dom	FAT4 TSPEAR NBEA CLSTN1 RYR3	3.96e-03	219	89	5	IPR013320
Domain	C2	SYT11 CAPN6 RIMS1 DYSF	4.18e-03	137	89	4	SM00239
Domain	RhoGEF	TRIO PREX1 ARHGEF10L	4.19e-03	68	89	3	SM00325
Domain	-	PSME4 UTP20 RIPOR1 PRKDC KPNA1	4.19e-03	222	89	5	1.25.10.10
Domain	PH_dom-like	TRIO MTMR1 NBEA PLD2 PREX1 PTK2 ARHGEF10L	4.23e-03	426	89	7	IPR011993
Domain	RhoGEF	TRIO PREX1 ARHGEF10L	4.55e-03	70	89	3	PF00621
Domain	HEAT_REPEAT	PSME4 UTP20 PRKDC	4.55e-03	70	89	3	PS50077
Domain	DH_2	TRIO PREX1 ARHGEF10L	4.55e-03	70	89	3	PS50010
Domain	DH-domain	TRIO PREX1 ARHGEF10L	4.73e-03	71	89	3	IPR000219
Domain	-	TRIO PREX1 ARHGEF10L	4.73e-03	71	89	3	1.20.900.10
Domain	C2	SYT11 CAPN6 RIMS1 DYSF	4.75e-03	142	89	4	PS50004
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF33 NLRP9 PRAMEF10 PRAMEF17 NLRP4	1.03e-08	28	91	5	25089626
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	GBF1 TRIO NUP210 CRYBG1 UTP20 PRKDC MAGEC1 ADPGK	6.34e-08	202	91	8	33005030
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	VPS13D SPG7 ATAD1 USP11 NUP210 DDX54 TUBGCP2 DNA2 ADPGK FAM83H KPNA1	5.51e-07	606	91	11	36538041
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NEK1 VPS13D TBC1D9B GBF1 NUP210 TBC1D12 TXNDC16 CLSTN1 PREX1	6.02e-06	493	91	9	15368895
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	TBC1D9B ATAD1 FDFT1 ADAM15 NUP210 ANAPC2 UTP20 PRKDC OCRL TUBGCP2 CLSTN1 NDUFB10	6.44e-06	942	91	12	31073040
Pubmed	Human meiotic recombinase Dmc1 promotes ATP-dependent homologous DNA strand exchange.	DMC1 RAD54B	6.77e-06	2	91	2	15164066
Pubmed	Potential role for ADAM15 in pathological neovascularization in mice.	ADAM15 PECAM1	6.77e-06	2	91	2	12897135
Pubmed	Signaling between focal adhesion kinase and trio.	TRIO PTK2	6.77e-06	2	91	2	12551902
Pubmed	ADAM15 protein amplifies focal adhesion kinase phosphorylation under genotoxic stress conditions.	ADAM15 PTK2	6.77e-06	2	91	2	22544741
Pubmed	Partial dysferlin reconstitution by adult murine mesoangioblasts is sufficient for full functional recovery in a murine model of dysferlinopathy.	PRKDC DYSF	6.77e-06	2	91	2	21364666
Pubmed	Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development.	PECAM1 PTK2	6.77e-06	2	91	2	20530207
Pubmed	Genetic Predictors of Salt Sensitivity of Blood Pressure: The Additive Impact of 2 Hits in the Same Biological Pathway.	ESR2 AGT	6.77e-06	2	91	2	34757767
Pubmed	Absence of T and B lymphocytes modulates dystrophic features in dysferlin deficient animal model.	PRKDC DYSF	6.77e-06	2	91	2	22465227
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PSME4 CLU WASHC5 ANAPC2 RAD54B MARF1 CLSTN1 DNA2 FHIP2A PTK2	8.01e-06	650	91	10	38777146
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	GMPS GBF1 ZFYVE16 USP11 NUP210 DDX54 MTMR1 TXNDC16 MCM2 PRKDC PLD2 KPNA1	9.01e-06	974	91	12	28675297
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF33 PRAMEF10 PRAMEF17	1.91e-05	20	91	3	26694250
Pubmed	Dynamin-2 reduction rescues the skeletal myopathy of a SPEG-deficient mouse model.	BIN1 SPEG	2.03e-05	3	91	2	35763354
Pubmed	Link of BIN1, CLU, and IDE Gene Polymorphisms with the Susceptibility of Alzheimer's Disease: Evidence from a Meta-analysis.	BIN1 CLU	2.03e-05	3	91	2	35546756
Pubmed	Biochemical analysis of the N-terminal domain of human RAD54B.	DMC1 RAD54B	2.03e-05	3	91	2	18718930
Pubmed	Focal adhesion kinase is required for blood vessel morphogenesis.	PECAM1 PTK2	2.03e-05	3	91	2	12595342
Pubmed	DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia.	DNAH5 DNAH6	2.03e-05	3	91	2	26918822
Pubmed	Clusterin/apolipoprotein J attenuates angiotensin II-induced renal fibrosis.	CLU AGT	2.03e-05	3	91	2	25148511
Pubmed	In silico identification and structural features of six new genes similar to MATER specifically expressed in the oocyte.	NLRP9 NLRP4	2.03e-05	3	91	2	15474461
Pubmed	The benefits of staying active in old age: physical activity counteracts the negative influence of PICALM, BIN1, and CLU risk alleles on episodic memory functioning.	BIN1 CLU	2.03e-05	3	91	2	24660791
Pubmed	Add-On Selective Estrogen Receptor Modulators for Methadone Maintenance Treatment.	ESR2 TMEM163	2.03e-05	3	91	2	34434167
Pubmed	Coupling factor 6 downregulates platelet endothelial cell adhesion molecule-1 via c-Src activation and acts as a proatherogenic molecule.	PECAM1 AGT	2.03e-05	3	91	2	18243211
Pubmed	Angiotensin II induces focal adhesion kinase/paxillin phosphorylation and cell migration in human umbilical vein endothelial cells.	AGT PTK2	2.03e-05	3	91	2	15652490
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF33 PRAMEF10 PRAMEF17	2.57e-05	22	91	3	31729367
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TBC1D9B GBF1 PSME4 SPG7 TRIO SPEG RIPOR1 PRKDC DYSF PREX1 ARHGEF10L FAM83H	3.12e-05	1105	91	12	35748872
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF33 PRAMEF10 PRAMEF17	3.82e-05	25	91	3	37451217
Pubmed	Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis.	ESR2 PRKDC	4.05e-05	4	91	2	26544941
Pubmed	Nogo-B receptor deficiency causes cerebral vasculature defects during embryonic development in mice.	PECAM1 TMEM163	4.05e-05	4	91	2	26746789
Pubmed	Somatic Mutation of NLRP Genes in Gastric and Colonic Cancers.	NLRP9 NLRP4	4.05e-05	4	91	2	34257569
Pubmed	Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.	BIN1 CLU	4.05e-05	4	91	2	21379329
Pubmed	Inhibition of phospholipase D by amphiphysins.	BIN1 PLD2	4.05e-05	4	91	2	10764771
Pubmed	Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease.	BIN1 CLU	4.05e-05	4	91	2	25051234
Pubmed	Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.	BIN1 CLU	4.05e-05	4	91	2	21347408
Pubmed	A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70.	MCM2 PRKDC	4.05e-05	4	91	2	19058849
Pubmed	A new role for the muscle repair protein dysferlin in endothelial cell adhesion and angiogenesis.	PECAM1 DYSF	4.05e-05	4	91	2	20724702
Pubmed	Expression of prion gene and presence of prion protein during development of mouse molar tooth germ.	CLU CLSTN1	4.05e-05	4	91	2	21083616
Pubmed	DNA-PKcs Negatively Regulates Cyclin B1 Protein Stability through Facilitating Its Ubiquitination Mediated by Cdh1-APC/C Pathway.	ANAPC2 PRKDC	4.05e-05	4	91	2	26221070
Pubmed	Updated Meta-Analysis of BIN1, CR1, MS4A6A, CLU, and ABCA7 Variants in Alzheimer's Disease.	BIN1 CLU	4.05e-05	4	91	2	29504051
Pubmed	Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis.	PECAM1 PTK2	4.05e-05	4	91	2	15967814
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	CELF5 VPS13D SPEG DDX54 RIPK2 NBEA DYSF RYR3	4.95e-05	497	91	8	36774506
Pubmed	Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development.	TRIO ESR2 NBEA	6.68e-05	30	91	3	38310234
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF33 PRAMEF10 PRAMEF17	6.68e-05	30	91	3	38786026
Pubmed	Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer's disease.	BIN1 CLU	6.74e-05	5	91	2	31878951
Pubmed	Vascular development of the brain requires beta8 integrin expression in the neuroepithelium.	PECAM1 TMEM163	6.74e-05	5	91	2	16251442
Pubmed	Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation.	PECAM1 PTK2	6.74e-05	5	91	2	16391003
Pubmed	Integrated late onset Alzheimer's disease (LOAD) susceptibility genes: Cholesterol metabolism and trafficking perspectives.	BIN1 CLU	6.74e-05	5	91	2	27773727
Pubmed	Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory.	BIN1 CLU	6.74e-05	5	91	2	22539578
Pubmed	Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals.	BIN1 CLU	6.74e-05	5	91	2	21059989
Pubmed	Regulation of nuclear receptor transcriptional activity by a novel DEAD box RNA helicase (DP97).	ESR2 DDX54	6.74e-05	5	91	2	12466272
Pubmed	The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease.	BIN1 CLU	6.74e-05	5	91	2	21627779
Pubmed	Developmental expression of the Sturge-Weber syndrome-associated genetic mutation in Gnaq: a formal test of Happle's paradominant inheritance hypothesis.	PECAM1 TMEM163	6.74e-05	5	91	2	37098137
Pubmed	ATR is a multifunctional regulator of male mouse meiosis.	DMC1 PRKDC	6.74e-05	5	91	2	29976923
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	FAT4 CLU FDFT1 ADAM15 AGT NUP210 TXNDC16 UTP20 TMCO3 CLSTN1 ADPGK FKBP14	6.96e-05	1201	91	12	35696571
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	GMPS TRIO ZFYVE16 WASHC5 FDFT1 NUP210 DDX54 MTMR1 CTDSP1 NBEA KPNA1	9.34e-05	1049	91	11	27880917
Pubmed	Defining human ERAD networks through an integrative mapping strategy.	PSME4 FDFT1 TXNDC16 MCM2 PRKDC	9.46e-05	173	91	5	22119785
Pubmed	Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.	ATAD1 FDFT1 ADAM15 NUP210 TXNDC16 PLD2	1.01e-04	282	91	6	35007762
Pubmed	Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal.	PECAM1 TMEM163	1.01e-04	6	91	2	16788063
Pubmed	Erk1 and Erk2 regulate endothelial cell proliferation and migration during mouse embryonic angiogenesis.	PECAM1 PTK2	1.01e-04	6	91	2	20011539
Pubmed	Molecular divergence of mammalian astrocyte progenitor cells at early gliogenesis.	CLU PECAM1	1.01e-04	6	91	2	35253855
Pubmed	Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix.	PECAM1 PTK2	1.01e-04	6	91	2	28348210
Pubmed	CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation.	PECAM1 TMEM163	1.01e-04	6	91	2	32883883
Pubmed	An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes.	KLHL6 RIPK2	1.01e-04	6	91	2	26018251
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF33 PRAMEF10 PRAMEF17	1.07e-04	35	91	3	19389355
Pubmed	Mutation of ARHGAP9 in patients with coronary spastic angina.	TRIO PREX1 ARHGEF10L	1.37e-04	38	91	3	19911011
Pubmed	Amphiphysin (BIN1) negatively regulates dynamin 2 for normal muscle maturation.	BIN1 DYSF	1.41e-04	7	91	2	29130937
Pubmed	Specific interactions of neuronal focal adhesion kinase isoforms with Src kinases and amphiphysin.	BIN1 PTK2	1.41e-04	7	91	2	12558988
Pubmed	Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network.	PECAM1 TMEM163	1.41e-04	7	91	2	28536097
Pubmed	Ubiquitous expression of Akt1 p.(E17K) results in vascular defects and embryonic lethality in mice.	PECAM1 TMEM163	1.41e-04	7	91	2	33030203
Pubmed	Focal adhesion kinase regulates smooth muscle cell recruitment to the developing vasculature.	PECAM1 PTK2	1.41e-04	7	91	2	21757658
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	NBEA FHIP2A DNAH5 ARHGEF10L	1.47e-04	101	91	4	10997877
Pubmed	Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.	PECAM1 PTK2	1.88e-04	8	91	2	20442405
Pubmed	Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest.	PECAM1 TMEM163	1.88e-04	8	91	2	16790550
Pubmed	Genome-wide analysis of genetic loci associated with Alzheimer disease.	BIN1 CLU	1.88e-04	8	91	2	20460622
Pubmed	Renin-angiotensin system is involved in embryonic emergence of hematopoietic stem/progenitor cells.	PECAM1 AGT	1.88e-04	8	91	2	33480126
Pubmed	The CXCL12/CXCR4 Axis Plays a Critical Role in Coronary Artery Development.	PECAM1 TMEM163	1.88e-04	8	91	2	26017770
Pubmed	Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study.	UTP20 DNAH5	1.88e-04	8	91	2	17903303
Pubmed	Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow.	FAT4 PECAM1	1.88e-04	8	91	2	32182215
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	GMPS BIN1 ATAD1 TRIO CLU SYT11 WASHC5 OGFR NBEA RIMS1 SLC4A4	1.91e-04	1139	91	11	36417873
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	MTMR1 HSF2 HELB	1.98e-04	43	91	3	33472061
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	GMPS PSME4 WASHC5 USP11 DDX54 MCM2 UTP20 PRKDC OCRL PTK2 FAM83H KPNA1	2.12e-04	1353	91	12	29467282
Pubmed	Essential role for the SLK protein kinase in embryogenesis and placental tissue development.	PECAM1 PTK2	2.41e-04	9	91	2	24868594
Pubmed	EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution.	PECAM1 PTK2	2.41e-04	9	91	2	17626061
Pubmed	Endothelial cell migration during murine yolk sac vascular remodeling occurs by means of a Rac1 and FAK activation pathway in vivo.	PECAM1 PTK2	2.41e-04	9	91	2	20737513
Pubmed	Recognition of cytosolic DNA activates an IRF3-dependent innate immune response.	RIPK2 PRKDC	2.41e-04	9	91	2	16413926
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	BIN1 TRIO CLU PTK2	2.86e-04	120	91	4	31413325
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	PRAMEF33 PRAMEF10 PRAMEF17	3.11e-04	50	91	3	31806660
Pubmed	Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice.	DMC1 PECAM1	3.67e-04	11	91	2	15289436
Pubmed	Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development.	PECAM1 PTK2	3.67e-04	11	91	2	19776009
Pubmed	Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis.	FDFT1 PECAM1	3.67e-04	11	91	2	19416849
Pubmed	MEMO1 drives cranial endochondral ossification and palatogenesis.	PECAM1 TMEM163	3.67e-04	11	91	2	26746790
Pubmed	Enhanced enteric neurogenesis by Schwann cell precursors in mouse models of Hirschsprung disease.	PECAM1 TMEM163	3.67e-04	11	91	2	34272903
Pubmed	Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculature.	PECAM1 TMEM163	3.67e-04	11	91	2	26385750
Pubmed	Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.	PECAM1 PTK2	3.67e-04	11	91	2	22734001
Pubmed	Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis.	PECAM1 PTK2	3.67e-04	11	91	2	26858344
Pubmed	Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.	BIN1 CLU	3.67e-04	11	91	2	21460841
Pubmed	Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice.	AGT PTK2	3.67e-04	11	91	2	16374517
Interaction	LRRC31 interactions	GBF1 TRIO ESR2 NUP210 CRYBG1 UTP20 PRKDC MAGEC1 ADPGK	3.08e-07	205	89	9	int:LRRC31
Interaction	MAS1 interactions	DENND6A SPG7 ATAD1 AGT PRKDC TUBGCP2	2.21e-06	86	89	6	int:MAS1
Interaction	GPR182 interactions	GBF1 SPG7 ATAD1 WASHC5 FDFT1 OGFR UTP20 PRKDC PLD2 TUBGCP2 ADPGK	5.16e-06	455	89	11	int:GPR182
Cytoband	1p36.21	PRAMEF33 PRAMEF10 PRAMEF17	2.74e-04	63	91	3	1p36.21
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	TRIO PREX1 ARHGEF10L	1.51e-03	66	62	3	722
GeneFamily	Dyneins, axonemal	DNAH5 DNAH6	1.52e-03	17	62	2	536
GeneFamily	Cadherin related	FAT4 CLSTN1	1.52e-03	17	62	2	24
GeneFamily	PRAME family	PRAMEF10 PRAMEF17	3.04e-03	24	62	2	686
GeneFamily	NLR family	NLRP9 NLRP4	3.30e-03	25	62	2	666
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP9 NLRP4	3.30e-03	25	62	2	994
GeneFamily	Phosphoinositide phosphatases	MTMR1 OCRL	5.37e-03	32	62	2	1079
Coexpression	GSE10147_IL3_VS_IL3_AND_CPG_STIM_PDC_DN	TXNDC16 CRYBG1 OCRL TUBGCP2 HSF2 HELB	2.14e-05	165	89	6	M353
Coexpression	GSE14415_INDUCED_TREG_VS_FAILED_INDUCED_TREG_DN	SLC25A24 SYT11 RAD54B CRYBG1 TMEM163 PREX1	3.28e-05	178	89	6	M2952
Coexpression	BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS	PRAMEF33 PRAMEF10 ZFYVE16 CAPN6 PRAMEF17 PLD2	3.50e-05	180	89	6	MM612
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3_UNMETHYLATED	PRAMEF10 SPEG PAPOLB PRAMEF17	4.28e-05	57	89	4	MM1262
Coexpression	GSE42724_NAIVE_VS_B1_BCELL_DN	NUP210 MRPL48 PRKDC CLSTN1 PREX1 NDUFB10	6.11e-05	199	89	6	M9796
Coexpression	GSE36009_WT_VS_NLRP10_KO_DC_LPS_STIM_DN	SLC25A24 VPS13D PSME4 ATAD1 FKBP14 KPNA1	6.11e-05	199	89	6	M8770
Coexpression	GSE13411_SWITCHED_MEMORY_BCELL_VS_PLASMA_CELL_UP	SLC25A24 VPS13D ZFYVE16 RIPK2 CRYBG1 PTK2	6.29e-05	200	89	6	M3251
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	FDFT1 TMEM163 RIMS1 SLC4A4 DNAH5 PTK2	2.22e-06	185	91	6	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FDFT1 NBEA RIMS1 SLC4A4 DNAH5	3.07e-05	176	91	5	3bbac5c2397535631fce8fa98f6ddb4fe0260351
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-cycling_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DMC1 ADAM15 PECAM1 MCM2 DYSF	3.24e-05	178	91	5	462111b61f37338f97ac7dc6c7da1d4316b54445
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|368C / Donor, Lineage, Cell class and subclass (all cells)	GBF1 OCRL TMCO3 PLD2 TMEM236	3.24e-05	178	91	5	536a601abcc60867949ea06e9aafb6c7b799b56b
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CNTD1 ADAM15 PECAM1 DYSF PREX1	3.41e-05	180	91	5	97e0dcb7cfbba60a782824c5e23995058609fcd4
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	TLE1 SPEG RIMS1 SLC4A4 RYR3	4.31e-05	189	91	5	b6d5dec55bf352f6ae19d8f488ae70aa10fb9a8f
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	BIN1 SYT11 FDFT1 FHIP2A PREX1	4.41e-05	190	91	5	91ba66d4b56c59523485b17738e93f14bb00afa4
ToppCell	PBMC-Severe-cDC_12\|Severe / Compartment, Disease Groups and Clusters	DMC1 NUP210 MCM2 PRKDC DNA2	4.41e-05	190	91	5	84ee185939bdefb10705b621a70da27701eadcee
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYT11 ADAM15 PECAM1 PREX1 RYR3	4.53e-05	191	91	5	b2c86cde341fe350143658c8a8a4a9edbce3f19b
ToppCell	PCW_07-8.5-Endothelial-Endothelial_immature-endo_immature_arterial1_(12)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ADAM15 PECAM1 CRYBG1 DYSF PREX1	4.76e-05	193	91	5	d338a7c0585b69947c37f44aa0381619493e31ea
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYT11 ADAM15 PECAM1 PREX1 RYR3	4.76e-05	193	91	5	2e72309607902dabe3218888b22a77fe941f3570
ToppCell	PCW_13-14-Endothelial-Endothelial_mature-endo_capillary_(2)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ADAM15 PECAM1 CRYBG1 DYSF PREX1	4.87e-05	194	91	5	3c31ac44e8cf4eca3ba7b8bfc05ad3e96a970956
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 ADAM15 ESR2 PECAM1 DYSF	4.87e-05	194	91	5	a429d22c8c9d0fd3bfa9f877a6364cecad68db30
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	DMC1 RAD54B MCM2 PRKDC DNA2	4.99e-05	195	91	5	cec7df321f372d05c94f97d6bb18891a5cc3dec3
ToppCell	3'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CLU ADAM15 PXDC1 PECAM1 RIPOR1	4.99e-05	195	91	5	d46955155e5b22d00939eaf5edfb8ac217d06e46
ToppCell	PCW_13-14-Endothelial-Endothelial_mature\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ADAM15 PECAM1 CRYBG1 DYSF PREX1	4.99e-05	195	91	5	31353269591c9eee84872838e91995d4a035da46
ToppCell	PCW_13-14-Endothelial-Endothelial_cycling-endo_proliferating1_(10)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ADAM15 PECAM1 CRYBG1 DYSF PREX1	5.12e-05	196	91	5	b826dce5b3daa8eb3d4a530b9564de58d9ce3767
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DMC1 RAD54B MCM2 PRKDC DNA2	5.12e-05	196	91	5	df366d76ea55f49e349d622effa57c1535df8400
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM15 PECAM1 DYSF PREX1 RYR3	5.24e-05	197	91	5	cd509e49bbdbf991cc5913960ff3ef275ad40628
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM15 PECAM1 DYSF PREX1 RYR3	5.24e-05	197	91	5	412cb5f37df57121ddd1492021445479c7cbccbf
ToppCell	PCW_13-14-Endothelial-Endothelial_cycling-endo_proliferating3_(3)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ADAM15 PECAM1 CRYBG1 DYSF PREX1	5.24e-05	197	91	5	aedc1e3ed6b558bf2f7649919f43049f8348ab85
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM15 PECAM1 DYSF PREX1 RYR3	5.37e-05	198	91	5	07701c73137947ed4a27e225975329235bbb8734
ToppCell	PCW_13-14-Endothelial-Endothelial_cycling\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ADAM15 PECAM1 CRYBG1 DYSF PREX1	5.37e-05	198	91	5	8fb624407abb9cb711d8d8a8665014cf6e39559a
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CLU FDFT1 NBEA SLC4A4 DNAH5	5.37e-05	198	91	5	5fc25b008a4d8d6bec83923a16f64dd9e1ff1f2d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM15 PECAM1 DYSF PREX1 RYR3	5.37e-05	198	91	5	fa84bf8533d1b91d2c2bcf06b710670605072b89
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM15 PECAM1 DYSF PREX1 RYR3	5.37e-05	198	91	5	0a172c6d997c7cfbad34b56e80121bd104dee67d
ToppCell	Transverse-(2)_B_cell-(24)_B_cell_cycling\|Transverse / shred on region, Cell_type, and subtype	DMC1 MCM2 TMCO3 DNA2 PTK2	5.63e-05	200	91	5	e3f9736227151f23f0e331eec0a7a15ce464b517
ToppCell	Transverse-B_cell-B_cell_cycling\|Transverse / Region, Cell class and subclass	DMC1 MCM2 TMCO3 DNA2 PTK2	5.63e-05	200	91	5	0e270f8019d9f22068ca426d661937262a5cd331
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Pi16_(Pi16)\|Thalamus / BrainAtlas - Mouse McCarroll V32	PECAM1 RAD54B DYSF HELB	2.05e-04	142	91	4	58bfff3284ae21150e4619511bd58622c16c5dde
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Pi16_(Pi16)--\|Thalamus / BrainAtlas - Mouse McCarroll V32	PECAM1 RAD54B DYSF HELB	2.05e-04	142	91	4	5fd737c1fee9d97aee8955f1bf378ead3fce138d
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Pi16_(Pi16)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	PECAM1 RAD54B DYSF HELB	2.05e-04	142	91	4	16f9945e835c3506b12d904778560d065a50f059
ToppCell	facs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-23\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ESR2 PDILT ZNF483 TMEM236	2.17e-04	144	91	4	e9d62f202f0fa8747961036ef0eafed91fe8a42f
ToppCell	LPS-IL1RA-Endothelial-Mes-Like-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SPEG RIMS1 OCRL RYR3	2.23e-04	145	91	4	90ca38c02325c5c637c32efdef634b54cc3cd105
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CLU RIMS1 SLC4A4 DNAH5	2.66e-04	152	91	4	1b2a39ae159e79f1fb18d6d164bd7acab5299fca
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Fibroblasts\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SPEG RIMS1 SLC4A4 FAM83H	3.01e-04	157	91	4	f086753b51860e23f1275bd75e8802d2a7d7b70a
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CLU AGT SLC4A4 NDUFB10	3.09e-04	158	91	4	c736834269c89e003c61a62b63e4e50dbf0e1538
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Granulocytic\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NLRP9 PECAM1 PLD2 DYSF	3.24e-04	160	91	4	3b5a335786165391fe983ff0585cd508733793aa
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Granulocytic-Neutrophil\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NLRP9 PECAM1 PLD2 DYSF	3.24e-04	160	91	4	2586035a1380bc56814a6db0ca773ad835666042
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TRIO TLE1 PXDC1 RIPOR1	3.31e-04	161	91	4	63f0b97c741b610c450f65fa5764d712bfe09ce8
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AGT RAD54B MCM2 RIMS1	3.39e-04	162	91	4	3f264263878af630921911c2b344ac56eb1e7099
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAM15 PECAM1 RAD54B TUBGCP2	3.47e-04	163	91	4	3efbbdc9cb2613bb76d8c2f07cd4ec1a2c51a622
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BIN1 TMEM163 DNAH5 RYR3	3.55e-04	164	91	4	1cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCell	BAL-Mild-cDC_11\|Mild / Compartment, Disease Groups and Clusters	BIN1 CASTOR2 HSF2 PTK2	3.55e-04	164	91	4	4bd9629d054545d1e3f9e5c127b5ac2388637106
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 ADAM15 PECAM1 DYSF	3.72e-04	166	91	4	ec719368295133da2f7ff587c5329ed6db1dd56d
ToppCell	droplet-Lung-nan-21m-Lymphocytic-Proliferating_NK\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELF5 CNTD1 NUP210 MCM2	3.72e-04	166	91	4	21ba5fd755c0fb31ada42a1b5d60bede0153323d
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2\|343B / Donor, Lineage, Cell class and subclass (all cells)	DMC1 RAD54B MCM2 TMEM236	3.81e-04	167	91	4	7efa0081e79f22b219eac64ffcaedb2179cde299
ToppCell	control-Myeloid-pDC\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CNTD1 ATAD1 ESR2 HSF2	3.89e-04	168	91	4	affc39c7568b7df4b36af6f5b0e3702a18b6268c
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-stromal_related-FDC\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CLU CAPN6 TMEM163 DNAH5	3.98e-04	169	91	4	49a54fb2ea9db5c45e107f304838c536908308bb
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SPEG AGT NLRP4 ARHGEF10L	4.16e-04	171	91	4	4ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	DMC1 RAD54B MCM2 DNA2	4.25e-04	172	91	4	e9b97f37bb1732ad9aa89c5e9b513d14022801ac
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NBEA RIMS1 SLC4A4 DNAH5	4.35e-04	173	91	4	464267a2ff3f5c387b6c9c6fa4dab135a221f448
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AGT NUP210 CAPN6 RIMS1	4.44e-04	174	91	4	7b2f35add804981c7d588a996bdbca6ec11a1ca5
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM15 ESR2 PECAM1 DYSF	4.44e-04	174	91	4	3d4c05ea5719ca65e85d1f15198453034791087c
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KLHL6 ADAM15 TLE1 PECAM1	4.54e-04	175	91	4	2e54961846c65b185d9bd6e305dd81205579d890
ToppCell	RSV-Healthy-2\|Healthy / Virus stimulation, Condition and Cluster	RAD54B DYSF DNA2 NDUFB10	4.54e-04	175	91	4	c47440c0b0513e67fe13b85f10dd8a8d42d0e9a3
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KLHL6 ADAM15 TLE1 PECAM1	4.54e-04	175	91	4	efa6a05f7417d46141b6e635f258c126b7a03aa1
ToppCell	RSV-Healthy-2\|RSV / Virus stimulation, Condition and Cluster	RAD54B DYSF DNA2 NDUFB10	4.54e-04	175	91	4	0e97189585b7afaf3bd622c3ef10c86412393829
ToppCell	facs-Aorta\|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PECAM1 DYSF DNAH5 DNAH6	4.64e-04	176	91	4	0b3491451be02c18a16cdb875645be47eb867a7f
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PECAM1 TSPEAR TMEM163 DYSF	4.74e-04	177	91	4	d6596a0b6fd146fefc27717c1a7dbaa3774cc644
ToppCell	Endothelial-A-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	FAT4 CLU SYT11 PAPOLB	4.84e-04	178	91	4	2f2602b9305d55f25afa9861dd6c6347ae179337
ToppCell	PCW_13-14-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ADAM15 PECAM1 CRYBG1 PREX1	4.84e-04	178	91	4	c227da59dc7beb73f84405bf13356bdeb59d9338
ToppCell	Club_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	CLU SYT11 RIMS1 SLC4A4	4.84e-04	178	91	4	be64d4be23fb96a4cdd7980c58880fdfe817747f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DMC1 RAD54B PRKDC DNA2	4.94e-04	179	91	4	88d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCell	facs-SCAT\|facs / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIO OGFR ADAM15 SLC4A4	5.05e-04	180	91	4	6c70b6b7480507fa94625013222ad338ee7dd1d9
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_vein-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAT4 CLU PXDC1 PECAM1	5.05e-04	180	91	4	27e8bbee388e64dd79d70b160b76d45b1f398006
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CRYBG1 SLC4A4 PTK2 ARHGEF10L	5.15e-04	181	91	4	b7c85fbef3c06d5dc32a2a58f8d3dfabf1d79d9f
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CLU ESR2 PECAM1 SLC4A4	5.26e-04	182	91	4	c7f2d24697affa530b748ab32b1d40bdc1bdc20a
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CLU ESR2 PECAM1 SLC4A4	5.26e-04	182	91	4	d95635b74e8cd8bc00bfe40340806b59fb9bee43
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NBEA RIMS1 SLC4A4 DNAH5	5.26e-04	182	91	4	3f1a666fe27dd7529c114539ed5f6b8ca585c875
ToppCell	facs-Lung-Endomucin-3m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLU PECAM1 MARF1 HSF2	5.37e-04	183	91	4	3dc6cbe803e5b8c4201faaf2e6445898d71684e6
ToppCell	facs-Lung-Endomucin-3m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PXDC1 PECAM1 MARF1 HSF2	5.37e-04	183	91	4	1e51aeaa8fc9383b424cce128a890e07cb6025f3
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADAM15 PECAM1 TSPEAR DYSF	5.37e-04	183	91	4	bc98df870de65aff6dab295c24cbc199c7f2aa15
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 SLC4A4 DNAH5 RYR3	5.48e-04	184	91	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Lung-Endomucin-3m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLU PECAM1 MARF1 HSF2	5.48e-04	184	91	4	af5eb3650fafc808828eb42f68c0f1e9c278adbb
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 SLC4A4 DNAH5 RYR3	5.48e-04	184	91	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	PCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC-im_ILC2_(21)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	KLHL6 NUP210 CRYBG1 PREX1	5.48e-04	184	91	4	33db879e629821fb75684e60f8f0749cf9623bdd
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 SLC4A4 DNAH5 RYR3	5.48e-04	184	91	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	E12.5-Endothelial-capillary_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KLHL6 ADAM15 PECAM1 DYSF	5.60e-04	185	91	4	e005d3c01a908157f780bbc1d53dd2ed814a39d2
ToppCell	BAL-Severe-Myeloid-Macrophage\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PECAM1 TBC1D12 TMEM163 PLD2	5.60e-04	185	91	4	ae966929fb5bbb08ffcbac76cb21941638727f55
ToppCell	BAL-Severe-Myeloid-Macrophage-transitional_Macro-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PECAM1 TBC1D12 TMEM163 PLD2	5.60e-04	185	91	4	3beebaa92275086b1fae5f8c0c3d54016c5ba2aa
ToppCell	BAL-Severe-Myeloid-Macrophage-transitional_Macro-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PECAM1 TBC1D12 TMEM163 PLD2	5.60e-04	185	91	4	ceff11cfa679147ccfd0a0f8079e697a6bea34d9
ToppCell	droplet-Liver-Hepatocytes-21m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 USP11 CASTOR2 DYSF	5.60e-04	185	91	4	efcfbf5a48b3ea9a425183e5c2eec6a9585415a0
ToppCell	droplet-Liver-Hepatocytes-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP11 TLE1 PECAM1 NBEA	5.60e-04	185	91	4	60206c7322b4ddb2010040aac70561df842c9843
ToppCell	droplet-Liver-Hepatocytes-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 USP11 CASTOR2 DYSF	5.60e-04	185	91	4	642088ace9230d38b0579853c54ff4dd8b5d5df4
ToppCell	facs-Lung-Endomucin-3m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLU PECAM1 MARF1 HSF2	5.60e-04	185	91	4	f262b441ea3fe7f69dff33d5f171000371f3a3e5
ToppCell	BAL-Severe-Myeloid-Macrophage\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	PECAM1 TBC1D12 TMEM163 PLD2	5.60e-04	185	91	4	9aea5ed8f9cee5ee933891203aac7adb85d68201
ToppCell	E12.5-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KLHL6 ADAM15 PECAM1 DYSF	5.60e-04	185	91	4	0bccc424d0466f7f82baa00127c733640a2d50fb
ToppCell	BAL-Severe-Myeloid-Macrophage-transitional_Macro\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	PECAM1 TBC1D12 TMEM163 PLD2	5.60e-04	185	91	4	42939b294ea3e871274d8b73124c850dc1904fd2
ToppCell	Severe_COVID-19-Myeloid-transitional_Macro\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	PECAM1 TBC1D12 TMEM163 PLD2	5.60e-04	185	91	4	f7ef0d7740b4cfedc38846e802898c402dc411fd
ToppCell	Endothelial-A-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	FAT4 CLU PECAM1 DYSF	5.60e-04	185	91	4	dee0b7ba2f338f0979d2306aedf52ac35a36b60c
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAT4 CLU PXDC1 PECAM1	5.60e-04	185	91	4	a7ae76058b2082020cadec49d63b9f4e24d21734
ToppCell	BAL-Severe-Myeloid-Macrophage-transitional_Macro\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PECAM1 TBC1D12 TMEM163 PLD2	5.60e-04	185	91	4	7a3612520ae4f0cd61480eadba31eecce001419d
ToppCell	Control-Myeloid-MoAM3,_VCAN\|Myeloid / Condition, Lineage and Cell class	CLU TMEM163 DYSF RYR3	5.71e-04	186	91	4	0bf16ac48931b62bb3c33d63ff4279654148e293
ToppCell	PCW_05-06-Endothelial-Endothelial_mature-endo_bronchial_(8)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	KLHL6 ADAM15 PECAM1 DYSF	5.71e-04	186	91	4	0cc7504297fd0c97ea50e4b3ff58fcedc4c1cfaa
ToppCell	PCW_05-06-Endothelial-Endothelial_cycling-endo_proliferating2_(14)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	KLHL6 ADAM15 PECAM1 DYSF	5.71e-04	186	91	4	2cbf1aaff87cd9fba01f814a119fe86e5af82290
ToppCell	droplet-Marrow-BM-30m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM15 NUP210 DNA2 ARHGEF10L	5.71e-04	186	91	4	bcb3ac9f9b51346e0a2b0bda96d149b3c11f7883
ToppCell	metastatic_Lymph_Node-Endothelial_cells-Tumor_ECs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	CNTD1 FAT4 CLU PECAM1	5.83e-04	187	91	4	2713f526f86911fbbf6c7a3e69230f2e6bde31c3
ToppCell	E12.5-Endothelial\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KLHL6 ADAM15 PECAM1 DYSF	5.83e-04	187	91	4	b8ed57b3c39ffbf750cd08a3e03ec11dae43d00e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM15 PECAM1 DYSF PREX1	5.83e-04	187	91	4	35c382c0aabd46906113e5db30ea24bb8e658899
ToppCell	PCW_07-8.5-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ADAM15 PECAM1 DYSF PREX1	5.83e-04	187	91	4	29b2e2be26a9d72b154760e47acf61cfe2f45fa7
Drug	Diltiazem hydrochloride [33286-22-5]; Down 200; 8.8uM; PC3; HT_HG-U133A	TBC1D9B ADAM15 MTMR1 PRKDC OCRL HSF2 PTK2	1.09e-05	191	90	7	6710_DN
Drug	5213008; Down 200; 18uM; MCF7; HT_HG-U133A_EA	DMC1 OGFR DDX54 RIPK2 RIPOR1 TMCO3 TUBGCP2	1.24e-05	195	90	7	898_DN
Drug	(-)-depudecin; Down 200; 1uM; MCF7; HT_HG-U133A_EA	TRIO OGFR RIPK2 TBC1D12 MTMR1 RIPOR1 DNA2	1.29e-05	196	90	7	982_DN
Drug	Suramin sodium salt; Down 200; 10uM; PC3; HT_HG-U133A	BIN1 NR2E3 TRIO CLU ADAM15 TUBGCP2 ARHGEF10L	1.37e-05	198	90	7	7501_DN
Drug	Iopamidol [60166-93-0]; Down 200; 5.2uM; PC3; HT_HG-U133A	VPS13D GBF1 TRIO OGFR ADAM15 SPEG ARHGEF10L	1.42e-05	199	90	7	5832_DN
Drug	Amiprilose hydrochloride [60414-06-4]; Down 200; 11.8uM; MCF7; HT_HG-U133A	BIN1 TLE1 RAD54B DDX54 TUBGCP2 SLC4A4 PTK2	1.47e-05	200	90	7	3339_DN
Drug	Ganciclovir [82410-32-0]; Down 200; 15.6uM; MCF7; HT_HG-U133A	DMC1 VPS13D PSME4 SPEG DYSF FKBP14	9.96e-05	187	90	6	3368_DN
Drug	AG-1478; Down 200; 31.6uM; MCF7; HT_HG-U133A_EA	TBC1D9B SPG7 ZFYVE16 NUP210 UTP20 DNA2	9.96e-05	187	90	6	1141_DN
Drug	Sulfamethoxazole [723-46-6]; Down 200; 15.8uM; MCF7; HT_HG-U133A	DMC1 PSME4 MTMR1 TMCO3 HSF2 FKBP14	1.09e-04	190	90	6	2296_DN
Drug	Promazine hydrochloride [53-60-1]; Down 200; 12.4uM; MCF7; HT_HG-U133A	NEK1 BIN1 VPS13D TRIO OGFR TLE1	1.09e-04	190	90	6	3833_DN
Drug	2-Aminobenzenesulfonamide [3306-62-5]; Down 200; 23.2uM; MCF7; HT_HG-U133A	DMC1 VPS13D PSME4 TRIO SPEG TUBGCP2	1.15e-04	192	90	6	3400_DN
Drug	Guanabenz acetate [23256-50-0]; Down 200; 13.8uM; PC3; HG-U133A	NEK1 BIN1 TRIO ZFYVE16 OGFR SLC4A4	1.18e-04	193	90	6	1961_DN
Drug	Chlorpromazine hydrochloride [69-09-0]; Down 200; 11.2uM; PC3; HT_HG-U133A	VPS13D OGFR SPEG SLC4A4 DNA2 ARHGEF10L	1.18e-04	193	90	6	5074_DN
Drug	Salbutamol [18559-94-9]; Down 200; 16.8uM; PC3; HT_HG-U133A	SYT11 SPEG ESR2 MTMR1 OCRL TUBGCP2	1.18e-04	193	90	6	3677_DN
Drug	Fenoprofen calcium salt dihydrate [53746-45-5]; Down 200; 7.2uM; MCF7; HT_HG-U133A	DMC1 PSME4 TLE1 MTMR1 TUBGCP2 DYSF	1.22e-04	194	90	6	4736_DN
Drug	(-)-Isoproterenol hydrochloride [5984-95-2]; Up 200; 16.2uM; MCF7; HT_HG-U133A	BIN1 SPEG AGT RIPOR1 MAGEC1 SLC4A4	1.22e-04	194	90	6	6833_UP
Drug	Cefsulodin sodium salt [52152-93-9]; Down 200; 7.2uM; MCF7; HT_HG-U133A	ADAM15 TLE1 RAD54B MTMR1 OCRL DYSF	1.25e-04	195	90	6	3328_DN
Drug	Ursolic acid [77-52-1]; Down 200; 8.8uM; PC3; HT_HG-U133A	VPS13D TRIO CLU RIPOR1 TMCO3 ARHGEF10L	1.25e-04	195	90	6	5825_DN
Drug	Benperidol [2062-84-2]; Down 200; 10.4uM; HL60; HT_HG-U133A	BIN1 ZFYVE16 OGFR ADAM15 MTMR1 SLC4A4	1.25e-04	195	90	6	2475_DN
Drug	Meclozine dihydrochloride [1104-22-9]; Down 200; 8.6uM; PC3; HT_HG-U133A	BIN1 ADAM15 NUP210 PRKDC OCRL SLC4A4	1.25e-04	195	90	6	4646_DN
Drug	Fenbufen [36330-85-5]; Down 200; 15.8uM; PC3; HT_HG-U133A	NEK1 TRIO OGFR MTMR1 TMCO3 PTK2	1.25e-04	195	90	6	3721_DN
Drug	Cephapirin sodium salt [24356-60-3]; Down 200; 9uM; PC3; HT_HG-U133A	ANAPC2 RIPOR1 OCRL PLD2 TUBGCP2 SLC4A4	1.29e-04	196	90	6	7142_DN
Drug	Sulfaguanidine [57-67-0]; Down 200; 18.6uM; PC3; HT_HG-U133A	FAT4 BIN1 TBC1D9B SPEG RAD54B SLC4A4	1.29e-04	196	90	6	4257_DN
Drug	Metyrapone [54-36-4]; Down 200; 17.6uM; MCF7; HT_HG-U133A	PSME4 OGFR RIPOR1 PLD2 TUBGCP2 HSF2	1.29e-04	196	90	6	6447_DN
Drug	Bambuterol hydrochloride [81732-46-9]; Down 200; 10uM; MCF7; HT_HG-U133A	DMC1 OGFR MTMR1 RIPOR1 SLC4A4 DYSF	1.29e-04	196	90	6	3199_DN
Drug	Hydroflumethiazide [135-09-1]; Down 200; 12uM; PC3; HT_HG-U133A	BIN1 VPS13D SPEG NUP210 HSF2 DYSF	1.29e-04	196	90	6	7259_DN
Drug	Lactobionic acid [96-82-2]; Down 200; 11.2uM; PC3; HT_HG-U133A	BIN1 VPS13D GBF1 TUBGCP2 SLC4A4 HSF2	1.29e-04	196	90	6	6605_DN
Drug	16, 16-dimethylprostaglandin E2 methyl acetate solution; Down 200; 10uM; PC3; HT_HG-U133A	NEK1 FDFT1 OGFR NUP210 PRKDC PTK2	1.29e-04	196	90	6	6562_DN
Drug	Phenformin hydrochloride [834-28-6]; Down 200; 16.6uM; MCF7; HT_HG-U133A	OGFR MTMR1 RIPOR1 TMCO3 SLC4A4 FKBP14	1.29e-04	196	90	6	2312_DN
Drug	beta- Belladonnine dichloroethylate [191355-47-2]; Down 200; 6uM; PC3; HT_HG-U133A	BIN1 PSME4 RAD54B MTMR1 PLD2 SLC4A4	1.29e-04	196	90	6	6638_DN
Drug	Convolamine hydrochloride [500-56-1]; Up 200; 11.8uM; HL60; HG-U133A	VPS13D ZFYVE16 OGFR ADAM15 TLE1 PLD2	1.32e-04	197	90	6	1779_UP
Drug	S-(+)-ibuprofen [51146-56-6]; Up 200; 19.4uM; MCF7; HT_HG-U133A	VPS13D SYT11 ESR2 RAD54B MTMR1 SLC4A4	1.32e-04	197	90	6	6471_UP
Drug	Tocopherol (R,S) [10191-41-0]; Down 200; 9.2uM; MCF7; HT_HG-U133A	OGFR ADAM15 TLE1 MTMR1 TUBGCP2 SLC4A4	1.32e-04	197	90	6	3256_DN
Drug	genistein; Down 200; 10uM; PC3; HG-U133A	BIN1 GBF1 SPG7 TRIO OGFR SLC4A4	1.32e-04	197	90	6	703_DN
Drug	aspirin, USP; Down 200; 100uM; HL60; HT_HG-U133A	TLE1 CRYBG1 OCRL SLC4A4 DYSF CLSTN1	1.32e-04	197	90	6	1145_DN
Drug	Bromocryptine mesylate [22260-51-1]; Down 200; 5.4uM; MCF7; HT_HG-U133A	TLE1 RIPK2 RIPOR1 TUBGCP2 SLC4A4 DNA2	1.32e-04	197	90	6	1507_DN
Drug	Proadifen hydrochloride [62-68-0]; Down 200; 10.2uM; PC3; HT_HG-U133A	OGFR ADAM15 SPEG ANAPC2 RIPOR1 OCRL	1.36e-04	198	90	6	5807_DN
Drug	LY 294002; Up 200; 0.1uM; MCF7; HT_HG-U133A	BIN1 SPG7 PXDC1 NUP210 RAD54B MTMR1	1.36e-04	198	90	6	6976_UP
Drug	Mebendazole [31431-39-7]; Down 200; 13.6uM; PC3; HT_HG-U133A	BIN1 TBC1D9B TRIO TLE1 NUP210 DDX54	1.36e-04	198	90	6	7370_DN
Drug	Chlorzoxazone [95-25-0]; Down 200; 23.6uM; PC3; HT_HG-U133A	VPS13D TBC1D9B GBF1 OGFR SPEG NUP210	1.36e-04	198	90	6	2100_DN
Drug	catechin; Down 200; 11uM; MCF7; HT_HG-U133A_EA	GBF1 TRIO ANAPC2 RIPK2 TBC1D12 NBEA	1.36e-04	198	90	6	1101_DN
Drug	Benzocaine [94-09-7]; Down 200; 24.2uM; MCF7; HT_HG-U133A	NEK1 BIN1 VPS13D PSME4 OGFR PLD2	1.36e-04	198	90	6	4808_DN
Drug	Sulfamethoxazole [723-46-6]; Down 200; 15.8uM; PC3; HT_HG-U133A	BIN1 TRIO OGFR NUP210 DDX54 RIPOR1	1.36e-04	198	90	6	7366_DN
Drug	Nifedipine [21829-25-4]; Down 200; 11.6uM; PC3; HT_HG-U133A	BIN1 TBC1D9B OGFR ANAPC2 PLD2 DNA2	1.36e-04	198	90	6	7303_DN
Drug	Minaprine dihydrochloride [25953-17-7]; Down 200; 10.8uM; PC3; HT_HG-U133A	OGFR TLE1 RAD54B MTMR1 OCRL TUBGCP2	1.36e-04	198	90	6	4230_DN
Drug	Heptaminol hydrochloride [543-15-7]; Down 200; 22uM; PC3; HT_HG-U133A	BIN1 GBF1 ZFYVE16 OGFR SPEG RIPOR1	1.36e-04	198	90	6	1825_DN
Drug	nordihydroguaiaretic acid; Down 200; 1uM; MCF7; HT_HG-U133A	VPS13D OGFR TLE1 DDX54 RIPOR1 ARHGEF10L	1.40e-04	199	90	6	6942_DN
Drug	AH6809; Up 200; 1uM; PC3; HT_HG-U133A	BIN1 TBC1D9B OGFR DDX54 DYSF ARHGEF10L	1.40e-04	199	90	6	7075_UP
Drug	minocycline; Up 200; 10.5uM; MCF7; HT_HG-U133A_EA	DMC1 TRIO MTMR1 HSF2 DNA2 KPNA1	1.40e-04	199	90	6	1135_UP
Drug	Trimetazidine dihydrochloride [13171-25-0]; Down 200; 11.8uM; HL60; HG-U133A	SLC25A24 VPS13D ZFYVE16 TUBGCP2 CLSTN1 KPNA1	1.40e-04	199	90	6	1727_DN
Drug	C070379	AGT PLD2 SLC4A4 HSF2 PTK2 RYR3	1.40e-04	199	90	6	CID003034747
Drug	Ranitidine hydrochloride [66357-59-3]; Down 200; 11.4uM; PC3; HT_HG-U133A	PSME4 CLU SPEG RIPOR1 OCRL ARHGEF10L	1.40e-04	199	90	6	6324_DN
Disease	Parkinson disease	GBF1 CLU FDFT1 TMEM163 RIMS1 OCRL KPNA1	4.69e-05	321	87	7	MONDO_0005180
Disease	Myopathy, Centronuclear, Autosomal Recessive	BIN1 SPEG	5.14e-05	4	87	2	C0410204
Disease	pre-eclampsia (is_implicated_in)	CLU ESR2 AGT	5.43e-05	25	87	3	DOID:10591 (is_implicated_in)
Disease	response to bevacizumab, Proteinuria	TRIO DNAH5	8.54e-05	5	87	2	EFO_0005943, HP_0000093
Disease	atherosclerosis (implicated_via_orthology)	CLU AGT	1.79e-04	7	87	2	DOID:1936 (implicated_via_orthology)
Disease	chemotherapy-induced alopecia, methylcobalamin deficiency type cblE	TRIO DNAH5	2.38e-04	8	87	2	EFO_0005400, MONDO_0009354
Disease	Mental deterioration	BIN1 CLU	3.05e-04	9	87	2	C0234985
Disease	Mild cognitive disorder	BIN1 CLU	3.05e-04	9	87	2	C1270972
Disease	Abnormality of the face	FDFT1 FHIP2A	3.05e-04	9	87	2	C4025871
Disease	systemic scleroderma (is_marker_for)	CLU PECAM1 AGT	5.21e-04	53	87	3	DOID:418 (is_marker_for)
Disease	Metastatic melanoma	TRIO PRKDC PTK2	5.51e-04	54	87	3	C0278883
Disease	pulmonary hypertension (implicated_via_orthology)	ESR2 PECAM1 AGT	5.51e-04	54	87	3	DOID:6432 (implicated_via_orthology)
Disease	Impaired cognition	BIN1 CLU	7.64e-04	14	87	2	C0338656
Disease	melanoma	FAT4 CLU CRYBG1 MAGEC1 FHIP2A	8.50e-04	248	87	5	C0025202
Disease	Autosomal Recessive Centronuclear Myopathy	BIN1 SPEG	8.80e-04	15	87	2	C3645536
Disease	selenium measurement, response to dietary selenium supplementation	TRIO DNAH5	1.58e-03	20	87	2	EFO_0006331, EFO_0600021
Disease	empathy measurement	TSPEAR TXNDC16 RIPOR1 DYSF	1.63e-03	170	87	4	EFO_0009183
Disease	Cardiac Arrhythmia	ESR2 AGT	2.47e-03	25	87	2	C0003811
Disease	chronic myeloid leukemia (is_marker_for)	PECAM1 AGT	2.88e-03	27	87	2	DOID:8552 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QFLTIFTLDELPREV	PRAMEF33	21	A0A0G2JMD5
LLPDISIEFLVIDFD	SYT11	371	Q9BT88
ELNITPELYEIFLSR	TBC1D12	501	O60347
FVSSLEEFQPDLVVL	ADPGK	246	Q9BRR6
RIDRFTFPALEEDVI	ARHGEF10L	116	Q9HCE6
FSFSPEREIRNVELL	ANAPC2	531	Q9UJX6
EVALLLDTFFRPLNV	ADAM15	241	Q13444
SIVLLDINDFVPVFE	FAT4	2246	Q6V0I7
QTDFILVRERDLPFV	CASTOR2	121	A6NHX0
ESSEGVFLFPELRII	CLSTN1	671	O94985
IIFIDTENTFRPDRL	DMC1	156	Q14565
EVLEVTLNRPFLFAV	AGT	441	P01019
PSAFEFNELFLITIL	MTMR1	516	Q13613
DPFLERITENVSFIF	RAD54B	886	Q9Y620
FSSLPFRDQVILLEE	NR2E3	241	Q9Y5X4
PSLRFITAERIELLF	NR2E3	376	Q9Y5X4
NVDLTEPIISRFDIL	MCM2	646	P49736
QRLIETLRPFGVFEE	PAPOLB	41	Q9NRJ5
IRIETVLPAEFFEVL	NUP210	386	Q8TEM1
PESTLIFNIDLLEIR	FKBP14	121	Q9NWM8
QFLTIFILDELPREV	PRAMEF17	21	Q5VTA0
FVQILNSEEFLDLPV	KLHL6	201	Q8WZ60
FIEILFGISLREVDP	MAGEC1	956	O60732
IPGFVELSLFDQVRL	ESR2	316	Q92731
RIEKFLSPQLIAEEF	NEK1	261	Q96PY6
PLFSSRFEEEELQRL	DDX54	546	Q8TDD1
VLEDFPTISLEFRNL	FDFT1	121	P37268
LEFPVEEQDRVLSFR	PECAM1	191	P16284
DLLPFFEQLSRVDDV	CTDSP1	236	Q9GZU7
FDLIVDRPVTLVREF	NDUFB10	31	O96000
FPEASIRLFAAELVL	RSKR	201	Q96LW2
FLVDPNLDLSIRELV	TUBGCP2	246	Q9BSJ2
SQPERLLFVIDSFEE	NLRP4	221	Q96MN2
FTDEILVSELQPFLD	RIMS1	1096	Q86UR5
DPGTIREEIQIFRLF	DNAH6	2311	Q9C0G6
RELFVQSEIFPLETP	GMPS	46	P49915
SEEDVLRLFQPFGVI	CELF5	146	Q8N6W0
LELTQSFIIPLERYV	DENND6A	441	Q8IWF6
ANELIRFEEFISDLP	MARF1	486	Q9Y4F3
LSEIEPNVFLRPFLE	GBF1	56	Q92538
DVEFSEPTIILFERE	CRYBG1	1496	Q9Y4K1
VFFILGEQREPETLA	FHIP2A	431	Q5W0V3
DEEFRILFAQSEPLV	FAM83H	271	Q6ZRV2
EQILSLFEDTFVPEI	BIN1	356	O00499
EFLLRIFSEVPVQLR	CAPN6	481	Q9Y6Q1
IFSEVPVQLRELTLD	CAPN6	486	Q9Y6Q1
LRDLIIDFREPQFIS	DNA2	591	P51530
ELFDEPIFITVVDSR	DYSF	276	O75923
REPQIVEFVFLLSEQ	CNTD1	51	Q8N815
SIQDKTFIFVRLPEE	HELB	691	Q8NG08
FDEFNRIDLPVLSVA	DNAH5	2031	Q8TE73
RQFSIDPDLLVDLFT	HSF2	381	Q03933
PLVRFFLEETLVRRE	OGFR	231	Q9NZT2
RPEDQKTLFVLFLIV	OR1L8	21	Q8NGR8
SRPLVIVGFFQDLEE	PDILT	171	Q8N807
LIFDSLVLEIFIDIS	TAS2R42	141	Q7RTR8
EEIQIFLDLLFEPVR	UTP20	1051	O75691
EVVLTFFERSPLDQV	PXDC1	121	Q5TGL8
TLLVTFDPEVFFNIL	SLC9A6	141	Q92581
TSIEPIRDFLAIVFF	TMCO3	546	Q6UWJ1
DSFRDLFIPRIETIL	LIPI	31	Q6XZB0
VPIFIELLSSEFEDV	KPNA1	171	P52294
REESILKFFEILSPV	PTK2	236	Q05397
EIFVDFAPFLSRTLL	NBEA	1901	Q8NFP9
INEDLVFLRPFSEVE	PREX1	671	Q8TCU6
FAEIFLEIIQSSLPE	MRPL48	166	Q96GC5
FIDLPTLQERREIFE	SPG7	476	Q9UQ90
FLPSLELSRREFVFE	OCRL	561	Q01968
IFEELTRDFLPQLSE	TBC1D9B	641	Q66K14
PSIIFIDEIDSFLRN	ATAD1	186	Q8NBU5
IIDELFQDRFFTREP	CLU	186	P10909
EKIEDIFSQPERILF	NLRP9	211	Q7RTR0
TIPESLDRIKEEFQF	TLE1	21	Q04724
LREFPTDTLFDVNAI	TXNDC16	111	Q9P2K2
IAELLRLSEFIPAVF	WASHC5	26	Q12768
SLAPLFTRLLEDVEV	SPEG	1061	Q15772
DDVRQILLLIDPSVF	RYR3	1741	Q15413
EPVLRTFEEITFLEA	RIPK2	291	O43353
QFLTIFTLDELPREV	PRAMEF10	21	O60809
PKFVEQLITFLSLED	PSME4	1316	Q14997
FLDVFLPRVTELALT	PRKDC	906	P78527
VFEQFLTILPGEIRI	ZNF483	96	Q8TF39
EVDFLDTPFIAFVRL	SLC4A4	291	Q9Y6R1
DLFPEEFSIVVTLRV	TSPEAR	81	Q8WU66
EETIFLPLLTEFLSI	RIPOR1	256	Q6ZS17
LLPEVDDFLFSVSIL	TMEM163	181	Q8TC26
TEFLEVSQLSFIPDL	PLD2	186	O14939
LDTLVEFPIRDLDFS	USP11	841	P51784
EFPIRDLDFSEFVIQ	USP11	846	P51784
FLFNPVTDIEEIIRF	SLC25A24	151	Q6NUK1
VFELLEFAAFSIPTL	TMEM236	11	Q5W0B7
RRIFLFEQIVIFSEP	TRIO	2186	O75962
NEDTIPKDIFRLFIT	ZFYVE16	1106	Q7Z3T8
IRFEDAVINLDPFTR	VPS13D	4021	Q5THJ4