Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentRab-protein geranylgeranyltransferase complex

CHM CHML

4.06e-054552GO:0005968
GeneOntologyCellularComponentplasma membrane bounded cell projection cytoplasm

EFHC2 SPATA7 FLOT2 RPGRIP1L MAP2 CFAP74

1.80e-04317556GO:0032838
GeneOntologyCellularComponentcytoplasmic region

EFHC2 SPATA7 FLOT2 RPGRIP1L MAP2 CFAP74

3.56e-04360556GO:0099568
GeneOntologyCellularComponentpolyprenyl diphosphate synthase complex

CHM CHML

4.41e-0412552GO:0032476
DomainRab_escort

CHM CHML

7.90e-062532IPR001738
DomainGDI

CHM CHML

4.72e-054532PF00996
DomainGDP_dissociation_inhibitor

CHM CHML

4.72e-054532IPR018203
DomainProtocadherin

PCDH11Y PCDH11X

7.86e-055532PF08374
DomainProtocadherin

PCDH11Y PCDH11X

7.86e-055532IPR013585
DomainWW

SMURF1 PLEKHA7 SMURF2

3.20e-0447533PF00397
DomainWW

SMURF1 PLEKHA7 SMURF2

3.41e-0448533SM00456
DomainWW_DOMAIN_2

SMURF1 PLEKHA7 SMURF2

4.08e-0451533PS50020
DomainWW_DOMAIN_1

SMURF1 PLEKHA7 SMURF2

4.08e-0451533PS01159
DomainWW_dom

SMURF1 PLEKHA7 SMURF2

4.32e-0452533IPR001202
DomainHECT

SMURF1 SMURF2

2.65e-0327532PF00632
DomainHECTc

SMURF1 SMURF2

2.65e-0327532SM00119
DomainHECT_dom

SMURF1 SMURF2

2.65e-0327532IPR000569
DomainHECT

SMURF1 SMURF2

2.65e-0327532PS50237
DomainPH

PLEKHD1 PLEKHA7 TIAM2 MPRIP

4.03e-03229534PF00169
DomainGST_CTER

GSTM5 GSTCD

4.18e-0334532PS50405
DomainGlutathione-S-Trfase_C-like

GSTM5 GSTCD

5.47e-0339532IPR010987
Domain-

GSTM5 GSTCD

5.47e-03395321.20.1050.10
DomainC2

RPGRIP1L SMURF1 SMURF2

6.12e-03131533PF00168
DomainABC_transporter_CS

ABCA1 ABCB11

6.33e-0342532IPR017871
DomainC2

RPGRIP1L SMURF1 SMURF2

6.92e-03137533SM00239
DomainC2

RPGRIP1L SMURF1 SMURF2

7.64e-03142533PS50004
DomainPH

PLEKHD1 PLEKHA7 TIAM2 MPRIP

7.94e-03278534SM00233
DomainPH_DOMAIN

PLEKHD1 PLEKHA7 TIAM2 MPRIP

8.04e-03279534PS50003
DomainPH_domain

PLEKHD1 PLEKHA7 TIAM2 MPRIP

8.14e-03280534IPR001849
DomainABC_tran

ABCA1 ABCB11

8.20e-0348532PF00005
DomainABC_TRANSPORTER_2

ABCA1 ABCB11

8.20e-0348532PS50893
DomainABC_TRANSPORTER_1

ABCA1 ABCB11

8.53e-0349532PS00211
Domain-

RPGRIP1L SMURF1 SMURF2

8.55e-031485332.60.40.150
DomainABC_transporter-like

ABCA1 ABCB11

8.87e-0350532IPR003439
Domain-

CHM CHML

1.10e-02565323.50.50.60
DomainC2_dom

RPGRIP1L SMURF1 SMURF2

1.13e-02164533IPR000008
Pubmed

The protocadherin 11X/Y (PCDH11X/Y) gene pair as determinant of cerebral asymmetry in modern Homo sapiens.

PCDH11Y PCDH11X

2.46e-06255223600975
Pubmed

A comparative analysis of the pig, mouse, and human PCDHX genes.

PCDH11Y PCDH11X

2.46e-06255215112107
Pubmed

The functions and regulation of Smurfs in cancers.

SMURF1 SMURF2

2.46e-06255231899247
Pubmed

Protocadherin 11X/Y a human-specific gene pair: an immunohistochemical survey of fetal and adult brains.

PCDH11Y PCDH11X

2.46e-06255222744706
Pubmed

Conservation of PCDHX in mammals; expression of human X/Y genes predominantly in brain.

PCDH11Y PCDH11X

2.46e-06255211003707
Pubmed

Pcdh11x Negatively Regulates Dendritic Branching.

PCDH11Y PCDH11X

2.46e-06255225687328
Pubmed

Mouse choroideremia gene mutation causes photoreceptor cell degeneration and is not transmitted through the female germline.

CHM CHML

2.46e-0625529175730
Pubmed

Cloning and characterization of the human choroideremia gene.

CHM CHML

2.46e-0625527981670
Pubmed

SMURF1 and SMURF2 in Progenitor Cells from Articular Cartilage and Meniscus during Late-Stage Osteoarthritis.

SMURF1 SMURF2

2.46e-06255233090007
Pubmed

Quantitative analysis of alternative transcripts of human PCDH11X/Y genes.

PCDH11Y PCDH11X

2.46e-06255219859901
Pubmed

Cadherin expression delineates the divisions of the postnatal and adult mouse amygdala.

PCDH11Y PCDH11X

2.46e-06255222592879
Pubmed

Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells.

SMURF1 SMURF2

2.46e-06255218927080
Pubmed

Protocadherin X ( PCDHX) and Y ( PCDHY) genes; multiple mRNA isoforms encoding variant signal peptides and cytoplasmic domains.

PCDH11Y PCDH11X

2.46e-06255214727141
Pubmed

Lack of association between protocadherin 11-X/Y (PCDH11X and PCDH11Y) polymorphisms and late onset Alzheimer's disease.

PCDH11Y PCDH11X

2.46e-06255221276771
Pubmed

ABCA1 Exerts Tumor-Suppressor Function in Myeloproliferative Neoplasms.

TET2 ABCA1

2.46e-06255232160545
Pubmed

Accelerated evolution of Protocadherin11X/Y: a candidate gene-pair for cerebral asymmetry and language.

PCDH11Y PCDH11X

2.46e-06255216874762
Pubmed

PCDH11 is X/Y homologous in Homo sapiens but not in Gorilla gorilla and Pan troglodytes.

PCDH11Y PCDH11X

2.46e-06255216825765
Pubmed

Tet2 regulates Barx2 expression in undifferentiated and early differentiated mouse embryonic stem cells.

TET2 BARX2

2.46e-06255233069358
Pubmed

The Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1.

SMURF1 SMURF2

7.36e-06355223475958
Pubmed

USF2 inhibits the transcriptional activity of Smurf1 and Smurf2 to promote breast cancer tumorigenesis.

SMURF1 SMURF2

7.36e-06355230244169
Pubmed

Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice.

SMURF1 SMURF2

7.36e-06355215173588
Pubmed

Where and what is the right shift factor or cerebral dominance gene? A critique of Francks et al. (2007).

PCDH11Y PCDH11X

7.36e-06355219125366
Pubmed

Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma.

SMURF1 SMURF2

7.36e-06355237537194
Pubmed

Bortezomib prevents oncogenesis and bone metastasis of prostate cancer by inhibiting WWP1, Smurf1 and Smurf2.

SMURF1 SMURF2

7.36e-06355225051198
Pubmed

Non-clustered protocadherin.

PCDH11Y PCDH11X

7.36e-06355221173574
Pubmed

Cadherin expression in the somatosensory cortex: evidence for a combinatorial molecular code at the single-cell level.

PCDH11Y PCDH11X

7.36e-06355221129452
Pubmed

Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.

SMURF1 SMURF2

7.36e-06355224925320
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

EHBP1 TET2 FLOT2 MAP2 ANKRD11 PLEKHA7 SPECC1 DOP1B MPRIP

7.68e-0686155936931259
Pubmed

Nedd8 targets ubiquitin ligase Smurf2 for neddylation and promote its degradation.

SMURF1 SMURF2

1.47e-05455227086113
Pubmed

Non-proteolytic ubiquitin modification of PPARγ by Smurf1 protects the liver from steatosis.

SMURF1 SMURF2

1.47e-05455230566427
Pubmed

Long non-coding RNA ARHGAP5-AS1 inhibits migration of breast cancer cell via stabilizing SMAD7 protein.

SMURF1 SMURF2

1.47e-05455234370213
Pubmed

Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.

SMURF1 SMURF2

1.47e-05455216373342
Pubmed

The WW1 Domain Enhances Autoinhibition in Smurf Ubiquitin Ligases.

SMURF1 SMURF2

1.47e-05455231628949
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

DOCK5 EHBP1 MAP2 MAN1C1 ANXA6 PCDH11Y TTC14 SMURF1 ANKRD11 SMURF2 KRCC1

1.80e-051489551128611215
Pubmed

TNF-alpha regulates mouse fetal hepatic maturation induced by oncostatin M and extracellular matrices.

ABCB11 CPS1

2.45e-05555215349890
Pubmed

Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity.

SMURF1 SMURF2

2.45e-05555220937913
Pubmed

Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice.

MYT1L MAP2

2.45e-05555235538503
Pubmed

Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease.

CHM CHML

2.45e-05555215186776
Pubmed

An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network.

SMURF1 SMURF2

2.45e-05555228839186
Pubmed

Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts.

SMURF1 SMURF2

2.45e-05555214722617
Pubmed

Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection.

SMURF1 SMURF2

2.45e-05555221402695
Pubmed

NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology.

SMURF1 SMURF2

2.45e-05555228798345
Pubmed

Inhibition of HECT E3 ligases as potential therapy for COVID-19.

SMURF1 SMURF2

2.45e-05555233762578
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

FLOT2 ANXA6 GSTCD SMURF1 ABCB11 ARMC9 PLEKHA7 TIAM2 DOP1B

2.84e-05101655919056867
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

DOCK5 EHBP1 FLOT2 CLCN7 PCDH11X PLEKHA7 SPECC1

3.11e-0556955730639242
Pubmed

ICAP-1 monoubiquitylation coordinates matrix density and rigidity sensing for cell migration through ROCK2-MRCKα balance.

SMURF1 SMURF2

3.67e-05655228049720
Pubmed

Cerebral cavernous malformation 2 protein promotes smad ubiquitin regulatory factor 1-mediated RhoA degradation in endothelial cells.

SMURF1 SMURF2

3.67e-05655219318350
Pubmed

Protocadherin 11 x regulates differentiation and proliferation of neural stem cell in vitro and in vivo.

PCDH11Y PCDH11X

3.67e-05655224647733
Pubmed

Hepatitis C virus/human interactome identifies SMURF2 and the viral protease as critical elements for the control of TGF-β signaling.

SMURF1 SMURF2

3.67e-05655223781096
Pubmed

Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling.

SMURF1 SMURF2

3.67e-05655221897371
Pubmed

REP-2, a Rab escort protein encoded by the choroideremia-like gene.

CHM CHML

3.67e-0565528294464
Pubmed

Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways.

SMURF1 SMURF2

3.67e-05655222921829
Pubmed

Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.

SMURF1 SMURF2

3.67e-05655232361710
Pubmed

CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription.

SMURF1 SMURF2

5.13e-05755214701756
Pubmed

A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases.

SMURF1 SMURF2

5.13e-05755230587574
Pubmed

SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis.

SMURF1 SMURF2

5.13e-05755227292644
Pubmed

The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function.

SMURF1 SMURF2

5.13e-05755228169289
Pubmed

A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover.

SMURF1 SMURF2

6.83e-05855219307600
Pubmed

Selective compounds enhance osteoblastic activity by targeting HECT domain of ubiquitin ligase Smurf1.

SMURF1 SMURF2

6.83e-05855228881580
Pubmed

Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.

SMURF1 SMURF2

6.83e-05855220484049
Pubmed

Formin 2 Regulates Lysosomal Degradation of Wnt-Associated β-Catenin in Neural Progenitors.

SMURF1 SMURF2

8.78e-05955229659741
Pubmed

Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).

SMURF1 SMURF2

1.10e-041055215221015
Pubmed

Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.

SMURF1 SMURF2

1.10e-041055225092867
Pubmed

Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.

SMURF1 SMURF2

1.10e-041055215138260
Pubmed

Structural determinants of Rab and Rab Escort Protein interaction: Rab family motifs define a conserved binding surface.

CHM CHML

1.34e-041155212535645
Pubmed

Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.

SMURF1 SMURF2

1.34e-041155217996703
Pubmed

delta-Protocadherins: a gene family expressed differentially in the mouse brain.

PCDH11Y PCDH11X

1.34e-041155215905963
Pubmed

USP11 augments TGFβ signalling by deubiquitylating ALK5.

SMURF1 SMURF2

1.34e-041155222773947
Pubmed

A MYT1L syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation.

MYT1L MAP2

1.34e-041155234614421
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

FLOT2 DMXL2 CLCN7 CHM CHML DOP1B

1.43e-0450455634432599
Pubmed

NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation.

SMURF1 SMURF2

1.60e-041255224107629
Pubmed

Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling.

TRIM33 SMURF1

1.60e-041255219917253
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

MYT1L TET2 TRIM33 DMXL2 SPECC1 SMURF2 CRTAP DOP1B MPRIP

1.71e-04128555935914814
Pubmed

Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.

PCDH11Y PCDH11X

1.89e-041355214660691
Pubmed

Genetic predisposition to tinnitus in the UK Biobank population.

EHBP1 MAP2

1.89e-041355234518561
Pubmed

TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.

SMURF1 SMURF2

2.21e-041455221791611
Pubmed

Stage-specific association of apolipoprotein A-I and E in developing mouse retina.

ABCA1 MAP2

2.21e-041455217389516
Pubmed

HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.

SMURF1 SMURF2

2.21e-041455226147758
Pubmed

Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer.

SMURF1 SMURF2

2.21e-041455229263404
Pubmed

Absence of layer-specific cadherin expression profiles in the neocortex of the reeler mutant mouse.

PCDH11Y PCDH11X

2.21e-041455220847152
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

MYT1L TTC14 ETS1 SMURF1 OTUD4 CPLANE1 PLEKHA7 TIAM2

2.88e-04108455811544199
Pubmed

Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.

SMURF1 SMURF2

2.90e-041655225723849
Pubmed

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.

ANKRD11 HEPH

2.90e-041655210932191
Pubmed

Identification of cAMP analogue inducible genes in RAW264 macrophages.

ABCA1 TTC14

2.90e-041655211004510
Pubmed

RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling.

SMURF1 SMURF2

3.29e-041755228292929
Pubmed

Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes.

PCDH11Y PCDH11X

3.29e-041755234879283
Pubmed

Discovery and refinement of loci associated with lipid levels.

EHBP1 ABCA1 ABCB11 CPS1

3.52e-0421155424097068
Pubmed

Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.

PTPN2 ETS1

3.70e-041855222446963
Pubmed

Genetically distinct subsets within ANCA-associated vasculitis.

PCDH11Y PCDH11X

3.70e-041855222808956
Pubmed

Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome.

PCDH11Y PCDH11X

4.13e-041955223920377
Pubmed

SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.

SMURF1 SMURF2

4.13e-041955221572392
Pubmed

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.

EHBP1 TET2

4.13e-041955219767753
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

MYT1L DMXL2 HEPH DOP1B

4.49e-0422555412168954
Pubmed

Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.

SMURF1 SMURF2

5.06e-042155237005481
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

EHBP1 FLOT2 PLEKHA7 SPECC1 MPRIP

5.37e-0442155536976175
Pubmed

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

EHBP1 DMXL2 MPRIP

5.43e-0410055310048485
Pubmed

Bone morphogenetic proteins.

SMURF1 SMURF2

6.08e-042355215621726
Pubmed

Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

MYT1L TRIM33 OTUD4

6.09e-0410455310470851
Pubmed

Regulation of planar cell polarity by Smurf ubiquitin ligases.

SMURF1 SMURF2

7.20e-042555219379695
Pubmed

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

SMURF1 SMURF2

7.79e-042655226949039
Cytoband4q24

TET2 GSTCD

7.71e-04345524q24
CytobandEnsembl 112 genes in cytogenetic band chr2q34

MAP2 CPS1

1.35e-0345552chr2q34
CytobandEnsembl 112 genes in cytogenetic band chr4q24

TET2 GSTCD

2.31e-0359552chr4q24
GeneFamilyNon-clustered protocadherins

PCDH11Y PCDH11X

2.51e-041236221
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PLEKHD1 PLEKHA7 TIAM2 MPRIP

7.25e-04206364682
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

RPGRIP1L SMURF2

2.33e-0336362823
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

RPGRIP1L CLCN7 PCDH11X

5.53e-03181363694
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_top-relative-expression-ranked_500

MYT1L DMXL2 ANXA6 CHM CPLANE1 SMURF2 SHISA6

5.36e-05387547gudmap_developingGonad_e18.5_ovary_500
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#3_top-relative-expression-ranked_1000

TTC14 PCDH11X ANKRD11 CHM CPLANE1 SMURF2

6.85e-05275546gudmap_developingGonad_e14.5_ epididymis_1000_k3
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#3_top-relative-expression-ranked_500

ANXA6 CHM CPLANE1 SMURF2

1.09e-0497544gudmap_developingGonad_e18.5_ovary_500_k3
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_top-relative-expression-ranked_1000

MYT1L EFHC2 DMXL2 ANXA6 ANKRD11 CHM CPLANE1 SMURF2 SHISA6

1.38e-04778549gudmap_developingGonad_e18.5_ovary_1000
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_top-relative-expression-ranked_1000

MYT1L EFHC2 DMXL2 ANXA6 ANKRD11 CHM CPLANE1 SMURF2 SHISA6

1.62e-04795549gudmap_developingGonad_e16.5_ovary_1000
CoexpressionAtlasratio_EmbryoidBody-blastocyst_vs_EmbryoidBody-fibro_top-relative-expression-ranked_1000_k-means-cluster#4

PCDH11Y VASH2 GSTCD ARMC9 SHISA6

1.64e-04203545ratio_EB-blastocyst_vs_EB-fibro_1000_K4
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_top-relative-expression-ranked_1000

DMXL2 ANXA6 TTC14 PCDH11X ETS1 ANKRD11 CHM CPLANE1 SMURF2

1.76e-04804549gudmap_developingGonad_e12.5_ovary_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k-means-cluster#2_top-relative-expression-ranked_1000

ABCA1 MAP2 TTC14 PCDH11X OTUD4 CPLANE1

1.86e-04330546DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k2_1000
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#2_top-relative-expression-ranked_1000

ANXA6 ANKRD11 CHM CPLANE1 SMURF2

1.92e-04210545gudmap_developingGonad_e18.5_ovary_1000_k2
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_k-means-cluster#2_top-relative-expression-ranked_1000

ANXA6 ANKRD11 CHM CPLANE1 SMURF2

2.93e-04230545gudmap_developingGonad_e16.5_ovary_1000_k2
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-4|TCGA-Thryoid / Sample_Type by Project: Shred V9

EHBP1 MAP2 SPECC1 DOP1B FAM111B

3.19e-06184555d9659d1e4465fec68f48a22edef443f354f6c7cf
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MAP2 SH2D3C PCDH11X ETS1 SPECC1

3.64e-061895556463890d8dbee4bc198f91628a5f784970de786a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MAP2 SH2D3C PCDH11X ETS1 SPECC1

3.83e-06191555b2c86cde341fe350143658c8a8a4a9edbce3f19b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAP2 SH2D3C PCDH11X ETS1 SPECC1

3.93e-06192555bacbaef1f230051335f4433e55db07a161b96b4c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MAP2 SH2D3C PCDH11X ETS1 SPECC1

4.03e-061935552e72309607902dabe3218888b22a77fe941f3570
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAP2 SH2D3C PCDH11X ETS1 SPECC1

4.24e-061955556bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCellControl-Myeloid-ncMonocyte|World / Disease state, Lineage and Cell class

DOCK5 TET2 DMXL2 ABCA1 SH2D3C

4.24e-06195555b4444b67a709e82b8e2ee510924c3152cb88b051
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

DMXL2 ABCA1 ANXA6 CHML

5.77e-051705549ac1ef57f14418a5dd2aa16861c3df698c28f5ed
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SH2D3C PCDH11X ETS1 FAM111B

6.90e-05178554375156ba1c7b8592bf733c75f24968161f7cfa09
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SH2D3C PCDH11X ETS1 SPECC1

6.90e-051785545f779a66aa42d1d8e8af17b4a08d5dcc733efd4c
ToppCellControl-Endothelial_cells-Capillary_endothelial_cells|Control / group, cell type (main and fine annotations)

PLA2G4C SH2D3C PCDH11X ETS1

7.21e-05180554b043f9ffb9a4cd427a15bebb86a711c7b08866e8
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

FLOT2 VASH2 SH2D3C ARMC9

7.21e-0518055481d60f0fa9e3b5bfcec85139a0a49e9130145f0e
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TET2 DMXL2 ABCA1 CHML

7.85e-05184554d1ea2b60fb1ca1a0b809d131310c43903a9e84ce
ToppCellLA-07._Pericyte|LA / Chamber and Cluster_Paper

MAP2 ETS1 SPECC1 SHISA6

8.01e-05185554ba5baa4d7f097108622674de5b7f4fd279843d24
ToppCellRV-07._Pericyte|RV / Chamber and Cluster_Paper

MAP2 SH2D3C SPECC1 SHISA6

8.18e-05186554c533b264fbe12bc35467486fc7fbde24ba968fe1
ToppCellRV-07._Pericyte|World / Chamber and Cluster_Paper

MAP2 SH2D3C SPECC1 SHISA6

8.35e-05187554dc274d6bbda619a2c914d84e2b4069cfef1739d1
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DOCK5 MAP2 SMURF1 MPRIP

8.52e-0518855443a3a59f92ad93509d4166bd025aed0b1b39a008
ToppCellCOPD-Myeloid-ncMonocyte|World / Disease state, Lineage and Cell class

DOCK5 TET2 SH2D3C ANKRD11

8.88e-05190554aece860b5609ad5a8fc920d685f0d0ec71bf9018
ToppCellLPS_only-Endothelial-Endothelial-Alv_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLA2G4C MAP2 SH2D3C ETS1

8.88e-05190554474cbbab8f3b0a6881fa6c92edb78e43999f9ab0
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MAP2 SH2D3C PCDH11X SPECC1

9.25e-0519255456b021c297a21dff357531f21e2464f85186106d
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ABCA1 ANKRD11 ARMC9 PLEKHA7

9.43e-05193554779276e775cb2492e8dd36436295a536084a6415
ToppCellT_cells-CD56_bright_CD16-_NK_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

EFHC2 ABCA1 RNF217 SPECC1

9.43e-05193554826457e2aafdb61ead8a0a44d8cf9088d310684b
ToppCellControl-Myeloid-ncMonocyte|Control / Disease state, Lineage and Cell class

DOCK5 TET2 ABCA1 SH2D3C

9.82e-05195554fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCellChildren_(3_yrs)-Immune-monocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

DOCK5 TET2 DMXL2 SPECC1

1.00e-04196554cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCellsevere-HLA-DR+_CD83+_Monocyte|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DOCK5 TET2 DMXL2 RNF217

1.04e-04198554a77f3440d7fb6a50066abc7e9ad59e83798ef13d
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Pericyte|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

MAP2 ANXA6 SH2D3C ETS1

1.04e-0419855472aad5b2dcd8b0bde58828fa4f8129fe6cb6a21d
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn-35|World / Primary Cells by Cluster

MYT1L TRIM33 MAP2 TIAM2

1.04e-04198554de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCellBronchial-10x5prime-Stromal-Fibroblastic-Fibro_immune_recruiting|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NPY5R PCDH11Y PCDH11X ABCB11

1.06e-041995540cdbedf09ec72734b86ddab3fec562e066afed92
ToppCellSigmoid-T_cell-Tfh|Sigmoid / Region, Cell class and subclass

MYT1L MAP2 PCDH11Y FAM111B

1.06e-04199554fa9404a021a015d1d571c324780b6eef2da47c4c
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6|World / Primary Cells by Cluster

MYT1L MAP2 PCDH11Y PCDH11X

1.06e-041995541b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

TET2 ANKRD11 SPECC1 KRCC1

1.06e-04199554c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCellSigmoid-(1)_T_cell-(16)_Tfh|Sigmoid / shred on region, Cell_type, and subtype

MYT1L MAP2 PCDH11Y FAM111B

1.06e-04199554a61bf52d2d359746433623ee00337124f1f84f61
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal|World / Primary Cells by Cluster

MYT1L MAP2 PCDH11Y PCDH11X

1.06e-041995544bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal|GW26 / Sample Type, Dataset, Time_group, and Cell type.

MYT1L MAP2 VASH2 DOP1B

1.06e-04199554a255484ba77bd2741a541da278efc8cf4abbe570
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal|GW16 / Sample Type, Dataset, Time_group, and Cell type.

MYT1L MAP2 VASH2 DOP1B

1.08e-0420055484e4565d28a02700bf7f6730d1b3a58744ca0aea
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal|GW16 / Sample Type, Dataset, Time_group, and Cell type.

MYT1L MAP2 VASH2 DOP1B

1.08e-042005541decf1d2cba5ebfd3e5cd4bcd637db8f193033ce
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

MYT1L MAP2 PCDH11Y PCDH11X

1.08e-04200554f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

MYT1L MAP2 PCDH11Y PCDH11X

1.08e-04200554cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

MYT1L MAP2 PCDH11Y PCDH11X

1.08e-04200554c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal|GW26 / Sample Type, Dataset, Time_group, and Cell type.

MYT1L MAP2 VASH2 DOP1B

1.08e-04200554306926cb7a847871641f02e03d52dc56fd55711c
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

MYT1L MAP2 PCDH11Y PCDH11X

1.08e-042005544fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellSigmoid-T_cell-Tfh|T_cell / Region, Cell class and subclass

MYT1L MAP2 PCDH11Y FAM111B

1.08e-04200554dd7dcf25520f065bf0d33d589f3c176f63875dc9
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

MYT1L MAP2 PCDH11Y PCDH11X

1.08e-04200554310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellcontrol-HLA-DR-_S100A+_Monocyte|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TET2 DMXL2 SPECC1 CRTAP

1.08e-042005549e3e13a68bc1110fa000ec2d80f4c654ddbce17e
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

MYT1L MAP2 PCDH11Y PCDH11X

1.08e-04200554961858738ce35db8760c8c2e136f8369bc444ccf
Diseasechoroideremia (implicated_via_orthology)

CHM CHML

3.17e-062532DOID:9821 (implicated_via_orthology)
DiseaseFamilial aplasia of the vermis

RPGRIP1L ARMC9 CPLANE1

2.15e-0530533C0431399
Diseaseatopic eczema, psoriasis

MYT1L PTPN2 ANXA6

3.75e-0536533EFO_0000274, EFO_0000676
Diseaseurate measurement, bone density

DOCK5 MAN1C1 ETS1 ANKRD11 COL6A5 TIAM2 CRTAP

1.15e-04619537EFO_0003923, EFO_0004531
Diseaseulcerative colitis

MYT1L TET2 PTPN2 ETS1 SMURF1

3.36e-04335535EFO_0000729
Diseaseureidopropionic acid measurement

RPGRIP1L CPS1

3.74e-0416532EFO_0010542
Diseaseopen-angle glaucoma

EFHC2 ABCA1 ETS1 PLEKHA7

3.89e-04191534EFO_0004190
DiseaseDisorder of eye

SPATA7 RPGRIP1L CHM CPLANE1

5.76e-04212534C0015397
DiseaseFamilial aplasia of the vermis

RPGRIP1L CPLANE1

5.89e-0420532cv:C0431399
DiseaseJoubert syndrome 1

ARMC9 CPLANE1

6.50e-0421532C4551568
Diseaselow density lipoprotein cholesterol measurement, alcohol consumption measurement

EHBP1 ABCA1 ABCB11

7.60e-0499533EFO_0004611, EFO_0007878
Diseaseinsulin sensitivity measurement

CPS1 SHISA6

7.82e-0423532EFO_0004471
Diseaselow density lipoprotein cholesterol measurement, alcohol drinking

EHBP1 ABCA1 ABCB11

8.29e-04102533EFO_0004329, EFO_0004611
DiseaseCiliopathies

SPATA7 RPGRIP1L CPLANE1

1.03e-03110533C4277690
Diseasepsoriasis

PTPN2 ANXA6 GSTCD ETS1

1.47e-03273534EFO_0000676
Diseasevital capacity

EHBP1 TET2 MAP2 GSTCD ETS1 OTUD4 SMURF2 TIAM2

1.54e-031236538EFO_0004312
DiseasePapillary Renal Cell Carcinoma

TET2 FPGT FAM111B

1.59e-03128533C1306837
DiseaseRenal Cell Carcinoma

TET2 FPGT FAM111B

1.59e-03128533C0007134
DiseaseSarcomatoid Renal Cell Carcinoma

TET2 FPGT FAM111B

1.59e-03128533C1266043
DiseaseChromophobe Renal Cell Carcinoma

TET2 FPGT FAM111B

1.59e-03128533C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

TET2 FPGT FAM111B

1.59e-03128533C1266044
Diseasefatty liver disease (biomarker_via_orthology)

ABCA1 CPS1

1.61e-0333532DOID:9452 (biomarker_via_orthology)
Diseasecholine measurement

ABCA1 ABCB11 CPS1

1.67e-03130533EFO_0010116

Protein segments in the cluster

PeptideGeneStartEntry
ELKLKSFTYEYEDSK

ANKRD11

651

Q6UB99
SFTIKDVYDKVDYLS

FLOT2

151

Q14254
YYLTLVKKDVESSLS

ABCA1

1126

O95477
SSLLAKVEKDYSYLK

SPECC1

616

Q5M775
LSVSKFTDYELKAYA

ABCB11

261

O95342
EYSSKTYSKVESDLL

DMXL2

2096

Q8TDJ6
AYKEDYHKSLEDALS

ANXA6

476

P08133
EEITFYEYLKTQKLT

CHM

316

P24386
AKYFIVEDSYLSEET

CHML

431

P26374
YTSTEEDLEKLFSKY

RBM19

411

Q9Y4C8
SLLYELLYEKVFKTD

OTUD4

166

Q01804
FSVKLLSEDVKSYYT

PTPN2

141

P17706
YASDKYKDIYTELSI

MPRIP

936

Q6WCQ1
ELLKENYDKLYDSAF

RPGRIP1L

356

Q68CZ1
DLDRYLKSESLSFYV

RPGRIP1L

851

Q68CZ1
LEYTDSSYVEKKYTL

GSTM5

21

P46439
LDEKISYFKTYLETK

ARMC9

121

Q7Z3E5
EDQSSYFFEKYSKDL

DOP1B

321

Q9Y3R5
NEKLLSLKYESLDYD

CLCN7

86

P51798
KSELSEYIKAEELYI

EFHC2

496

Q5JST6
ISSEELLSLKYENDY

ETS1

191

P14921
FLLETAAYLDYESTK

PCDH11X

416

Q9BZA7
YESTKEYAIKLLAAD

PCDH11X

426

Q9BZA7
YDTFKLADTYTLDVV

PLA2G4C

486

Q9UP65
DTEYLFDSFFSLIKK

CPS1

386

P31327
SKELAETYESKVFDY

DOCK5

1321

Q9H7D0
DDDEYIKFLDLFLSY

CPLANE1

1546

Q9H799
DYIKDLETKSYESLF

CRTAP

196

O75718
LSKETCDYFEKLSLY

BARX2

31

Q9UMQ3
LKSYADLETYSTKFL

COL6A5

396

A8TX70
SKYLYADSSKTEEEE

EHBP1

351

Q8NDI1
ETLKYLYLLFSEDDL

MAN1C1

586

Q9NR34
KTYDSFQDELEDYIK

KRCC1

6

Q9NPI7
LYKSLNDEKLETYDE

FAM111B

701

Q6SJ93
KSLTEEEYLYLDFSH

GSTCD

6

Q8NEC7
KLSSLLTYEDKSLYD

CFAP74

671

Q9C0B2
LTYEDKSLYDKAATS

CFAP74

676

Q9C0B2
IADLKLDSDYVYTDS

FPGT

271

O14772
LDYESTKEYAIKLLA

PCDH11Y

456

Q9BZA8
LYLDESKTLYDKLSI

TAS2R42

166

Q7RTR8
LYFEDKLTEIYSDRT

TRIM33

1071

Q9UPN9
DDYKSSVDDLQYFLI

NPY5R

31

Q15761
TIYKEYKDDSYTDEV

HEPH

76

Q9BQS7
SADDTYLQLKKDLEY

PLEKHA7

651

Q6IQ23
YSSLKRLTDKEADEY

SHISA6

311

Q6ZSJ9
NLTHEDSIKYKYFLE

RNF217

321

Q8TC41
SYEKLYEKLLTAVEE

SMURF1

736

Q9HCE7
ESYEKLYEKLLTAIE

SMURF2

726

Q9HAU4
EKSYVKDLSCLFELY

TIAM2

1111

Q8IVF5
ESFLLYYSESEKKSF

PLEKHD1

56

A6NEE1
TDLEYKYITKNLLSE

ZNF546

131

Q86UE3
RKIYSDEEELLYLSF

SPATA7

356

Q9P0W8
AESYYKKALALDETF

TTC14

401

Q96N46
SDLIFDFEDSYKKYL

VASH2

226

Q86V25
LSEYKTETYDDYKDE

MAP2

1361

P11137
SDYVKFSKEKYILDS

SH2D3C

181

Q8N5H7
ADKLYSELTETLRKY

TET2

1241

Q6N021
KELEKYSKTSFEYNS

MYT1L

636

Q9UL68