Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	6.16e-07	5	80	3	GO:0030156
GeneOntologyMolecularFunction	alpha-tocopherol omega-hydroxylase activity	CYP4F8 CYP4F12	1.57e-04	5	80	2	GO:0052871
GeneOntologyMolecularFunction	transition metal ion binding	NEK4 TBXAS1 CYP4F8 HIVEP1 AOC1 RBBP6 CYP27B1 MMP23B GATA6 CYP4F12 GRIN2B ZMIZ1 AGBL5 RBM20	2.45e-04	1189	80	14	GO:0046914
GeneOntologyMolecularFunction	ubiquitin-modified histone reader activity	RNF169 TP53BP1	3.29e-04	7	80	2	GO:0061649
GeneOntologyMolecularFunction	leukotriene-B4 20-monooxygenase activity	CYP4F8 CYP4F12	3.29e-04	7	80	2	GO:0050051
GeneOntologyMolecularFunction	alkane 1-monooxygenase activity	CYP4F8 CYP4F12	3.29e-04	7	80	2	GO:0018685
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	CYP4F8 CYP27B1 CYP4F12	5.50e-04	40	80	3	GO:0016709
GeneOntologyMolecularFunction	arachidonate omega-hydroxylase activity	CYP4F8 CYP4F12	6.99e-04	10	80	2	GO:0052869
GeneOntologyMolecularFunction	fatty acid omega-hydroxylase activity	CYP4F8 CYP4F12	6.99e-04	10	80	2	GO:0120250
GeneOntologyMolecularFunction	long-chain fatty acid omega-hydroxylase activity	CYP4F8 CYP4F12	6.99e-04	10	80	2	GO:0102033
GeneOntologyMolecularFunction	monooxygenase activity	TBXAS1 CYP4F8 CYP27B1 CYP4F12	1.18e-03	115	80	4	GO:0004497
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP4F8 CYP4F12	1.20e-03	13	80	2	GO:0016713
GeneOntologyMolecularFunction	arachidonate binding	CYP4F8 CYP4F12	1.61e-03	15	80	2	GO:0050544
GeneOntologyMolecularFunction	icosanoid binding	CYP4F8 CYP4F12	1.83e-03	16	80	2	GO:0050542
GeneOntologyMolecularFunction	icosatetraenoic acid binding	CYP4F8 CYP4F12	1.83e-03	16	80	2	GO:0050543
GeneOntologyCellularComponent	core-binding factor complex	RUNX1 RUNX3	4.33e-05	3	80	2	GO:0016513
GeneOntologyCellularComponent	manchette	RIMBP3 RIMBP3C RIMBP3B	1.65e-04	28	80	3	GO:0002177
MousePheno	detached sperm flagellum	RIMBP3 EGR4 RIMBP3C RIMBP3B	2.71e-06	21	67	4	MP:0008893
MousePheno	detached acrosome	RIMBP3 RIMBP3C AGBL5 RIMBP3B	5.66e-05	44	67	4	MP:0009231
MousePheno	abnormal manchette morphology	RIMBP3 RIMBP3C AGBL5 RIMBP3B	6.19e-05	45	67	4	MP:0009376
MousePheno	ectopic manchette	RIMBP3 RIMBP3C RIMBP3B	9.65e-05	19	67	3	MP:0009377
MousePheno	abnormal acrosome morphology	RIMBP3 SPEM2 RIMBP3C AGBL5 RIMBP3B JAM3	1.11e-04	159	67	6	MP:0008898
MousePheno	kinked sperm flagellum	RIMBP3 EGR4 RIMBP3C RIMBP3B	1.47e-04	56	67	4	MP:0009237
Domain	SH3_9	RIMBP3 RIMBP3C RIMBP3B ARHGEF16 SH3BP4	2.10e-05	78	80	5	PF14604
Domain	Cyt_P450_E_grp-I	TBXAS1 CYP4F8 CYP27B1 CYP4F12	4.07e-05	45	80	4	IPR002401
Domain	Runt	RUNX1 RUNX3	5.42e-05	3	80	2	PF00853
Domain	Runt_dom	RUNX1 RUNX3	5.42e-05	3	80	2	IPR013524
Domain	RunxI_C_dom	RUNX1 RUNX3	5.42e-05	3	80	2	IPR013711
Domain	RUNT	RUNX1 RUNX3	5.42e-05	3	80	2	PS51062
Domain	Runx_central_dom	RUNX1 RUNX3	5.42e-05	3	80	2	IPR027384
Domain	-	RUNX1 RUNX3	5.42e-05	3	80	2	4.10.770.10
Domain	TF_Runt-rel_RUNX	RUNX1 RUNX3	5.42e-05	3	80	2	IPR016554
Domain	RunxI	RUNX1 RUNX3	5.42e-05	3	80	2	PF08504
Domain	AML1_Runt	RUNX1 RUNX3	5.42e-05	3	80	2	IPR000040
Domain	Cyt_P450_CS	TBXAS1 CYP4F8 CYP27B1 CYP4F12	7.79e-05	53	80	4	IPR017972
Domain	CYTOCHROME_P450	TBXAS1 CYP4F8 CYP27B1 CYP4F12	1.04e-04	57	80	4	PS00086
Domain	-	TBXAS1 CYP4F8 CYP27B1 CYP4F12	1.11e-04	58	80	4	1.10.630.10
Domain	p450	TBXAS1 CYP4F8 CYP27B1 CYP4F12	1.11e-04	58	80	4	PF00067
Domain	Cyt_P450	TBXAS1 CYP4F8 CYP27B1 CYP4F12	1.27e-04	60	80	4	IPR001128
Domain	p53/RUNT-type_TF_DNA-bd	RUNX1 RUNX3	2.69e-04	6	80	2	IPR012346
Domain	-	RUNX1 RUNX3	2.69e-04	6	80	2	2.60.40.720
Domain	SH3_2	RIMBP3 RIMBP3C RIMBP3B SH3BP4	5.08e-04	86	80	4	IPR011511
Domain	SH3_2	RIMBP3 RIMBP3C RIMBP3B SH3BP4	5.08e-04	86	80	4	PF07653
Domain	-	SVEP1 STAB1	9.72e-04	11	80	2	2.40.155.10
Domain	GFP-like	SVEP1 STAB1	9.72e-04	11	80	2	IPR023413
Domain	SH3	RIMBP3 RIMBP3C RIMBP3B ARHGEF16 SH3BP4	2.35e-03	216	80	5	SM00326
Domain	SH3	RIMBP3 RIMBP3C RIMBP3B ARHGEF16 SH3BP4	2.35e-03	216	80	5	PS50002
Domain	SH3_domain	RIMBP3 RIMBP3C RIMBP3B ARHGEF16 SH3BP4	2.54e-03	220	80	5	IPR001452
Pathway	REACTOME_EICOSANOIDS	TBXAS1 CYP4F8 CYP4F12	7.48e-06	12	47	3	M27129
Pathway	REACTOME_EICOSANOIDS	TBXAS1 CYP4F8 CYP4F12	7.48e-06	12	47	3	MM14845
Pathway	REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS	TBXAS1 CYP4F8 AOC1 CYP27B1 CYP4F12	2.38e-05	104	47	5	M738
Pathway	REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS	TBXAS1 CYP4F8 AOC1 CYP27B1 CYP4F12	2.49e-05	105	47	5	MM14842
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	TBXAS1 CYP4F8 CYP27B1 CYP4F12	5.95e-05	64	47	4	M5650
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	TBXAS1 CYP4F8 CYP27B1 CYP4F12	6.72e-05	66	47	4	MM14839
Pathway	PID_SMAD2_3NUCLEAR_PATHWAY	FOS RUNX1 RUNX3 TFE3	1.57e-04	82	47	4	M2
Pathway	WP_EICOSANOID_METABOLISM_VIA_CYCLOOXYGENASES_COX	TBXAS1 CYP4F8 CYP4F12	1.77e-04	33	47	3	MM15918
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	4.86e-08	4	81	3	19091768
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	1.21e-07	5	81	3	17855024
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	NEK4 JCAD USP6 CNKSR1 RAB3GAP1 HIVEP1 TMTC3 FGD5 TFE3 AHNAK2	2.35e-06	638	81	10	31182584
Pubmed	Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.	TBXAS1 CYP4F8 CYP27B1 CYP4F12	3.45e-06	44	81	4	12745259
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B	4.35e-06	14	81	3	17662146
Pubmed	Localization of the domains in Runx transcription factors required for the repression of CD4 in thymocytes.	RUNX1 RUNX3	5.36e-06	2	81	2	15034051
Pubmed	USP32 is an active, membrane-bound ubiquitin protease overexpressed in breast cancers.	USP6 USP32	5.36e-06	2	81	2	20549504
Pubmed	Runx1 and Runx3 drive progenitor to T-lineage transcriptome conversion in mouse T cell commitment via dynamic genomic site switching.	RUNX1 RUNX3	5.36e-06	2	81	2	33479171
Pubmed	Runx1 and Runx3 Are Downstream Effectors of Nanog in Promoting Osteogenic Differentiation of the Mouse Mesenchymal Cell Line C3H10T1/2.	RUNX1 RUNX3	5.36e-06	2	81	2	26053522
Pubmed	Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8.	CYP4F8 CYP4F12	5.36e-06	2	81	2	16112640
Pubmed	Expression patterns and prognostic value of RUNX genes in kidney cancer.	RUNX1 RUNX3	5.36e-06	2	81	2	34294773
Pubmed	Neuroblastoma cell proliferation is sensitive to changes in levels of RUNX1 and RUNX3 protein.	RUNX1 RUNX3	5.36e-06	2	81	2	21640801
Pubmed	Downregulation of RUNX1 by RUNX3 requires the RUNX3 VWRPY sequence and is essential for Epstein-Barr virus-driven B-cell proliferation.	RUNX1 RUNX3	5.36e-06	2	81	2	19403666
Pubmed	Runx1/3-driven adaptive endoplasmic reticulum stress pathways contribute to neurofibromagenesis.	RUNX1 RUNX3	5.36e-06	2	81	2	36759572
Pubmed	Transcriptional repression of the RUNX3/AML2 gene by the t(8;21) and inv(16) fusion proteins in acute myeloid leukemia.	RUNX1 RUNX3	5.36e-06	2	81	2	18663147
Pubmed	Spatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis.	RUNX1 RUNX3	5.36e-06	2	81	2	11731260
Pubmed	USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7.	USP32 RAB7A	5.36e-06	2	81	2	30926795
Pubmed	RUNX super-enhancer control through the Notch pathway by Epstein-Barr virus transcription factors regulates B cell growth.	RUNX1 RUNX3	5.36e-06	2	81	2	26883634
Pubmed	Coexpression of Runx1 and Runx3 in mechanoreceptive dorsal root ganglion neurons.	RUNX1 RUNX3	5.36e-06	2	81	2	23378040
Pubmed	Retroviral insertional mutagenesis identifies RUNX genes involved in chronic myeloid leukemia disease persistence under imatinib treatment.	RUNX1 RUNX3	5.36e-06	2	81	2	17360569
Pubmed	Transcriptional cross-regulation of RUNX1 by RUNX3 in human B cells.	RUNX1 RUNX3	5.36e-06	2	81	2	15688019
Pubmed	RUNX3-mediated repression of RUNX1 in B cells.	RUNX1 RUNX3	5.36e-06	2	81	2	19603429
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	RNF169 HIVEP1 RBBP6 FHOD1 TJAP1 TNKS1BP1 RUNX1 ZNF768 TP53BP1 CYTH4	1.27e-05	774	81	10	15302935
Pubmed	Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia.	HAVCR2 RUNX1 RUNX3	1.57e-05	21	81	3	15514019
Pubmed	Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone development.	RUNX1 RUNX3	1.60e-05	3	81	2	14516670
Pubmed	The lncRNA RUNX1-IT1 regulates C-FOS transcription by interacting with RUNX1 in the process of pancreatic cancer proliferation, migration and invasion.	FOS RUNX1	1.60e-05	3	81	2	32487998
Pubmed	Runx1 transcription factor is involved in the regulation of KAP5 gene expression in human hair follicles.	RUNX1 RUNX3	1.60e-05	3	81	2	16442267
Pubmed	Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity.	RUNX1 RUNX3	1.60e-05	3	81	2	16684349
Pubmed	Integrin-α9 overexpression underlies the niche-independent maintenance of leukemia stem cells in acute myeloid leukemia.	RUNX1 RUNX3	1.60e-05	3	81	2	39002785
Pubmed	Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses.	RUNX1 RUNX3	1.60e-05	3	81	2	29222089
Pubmed	Roles of VWRPY motif-mediated gene repression by Runx proteins during T-cell development.	RUNX1 RUNX3	1.60e-05	3	81	2	22370763
Pubmed	AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization.	RUNX1 RUNX3	1.60e-05	3	81	2	7835892
Pubmed	Shared and distinct roles mediated through C-terminal subdomains of acute myeloid leukemia/Runt-related transcription factor molecules in murine development.	RUNX1 RUNX3	1.60e-05	3	81	2	15713794
Pubmed	Genetic regulation of the RUNX transcription factor family has antitumor effects.	RUNX1 RUNX3	1.60e-05	3	81	2	28530640
Pubmed	Identification and chromosomal mapping of a third mouse runt-like locus.	RUNX1 RUNX3	1.60e-05	3	81	2	7607689
Pubmed	Olfactory-Experience- and Developmental-Stage-Dependent Control of CPEB4 Regulates c-Fos mRNA Translation for Granule Cell Survival.	FOS CPEB4	1.60e-05	3	81	2	29166615
Pubmed	Identification and comparative analysis of a second runx3 promoter.	RUNX1 RUNX3	1.60e-05	3	81	2	11483356
Pubmed	RUNX Poly(ADP-Ribosyl)ation and BLM Interaction Facilitate the Fanconi Anemia Pathway of DNA Repair.	RUNX1 RUNX3	1.60e-05	3	81	2	30110632
Pubmed	Runx1 mediates the development of the granular convoluted tubules in the submandibular glands.	RUNX1 RUNX3	1.60e-05	3	81	2	28877240
Pubmed	GATA factors in endocrine neoplasia.	AMHR2 GATA6	1.60e-05	3	81	2	26027919
Pubmed	Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer.	RUNX1 RUNX3	1.60e-05	3	81	2	15386419
Pubmed	Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis.	RUNX1 RUNX3	1.60e-05	3	81	2	12796513
Pubmed	Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.	GATA6 AGBL5 BTRC	2.70e-05	25	81	3	29593216
Pubmed	Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice.	USP6 USP32 PLCB4 SH3BP4	2.77e-05	74	81	4	23604909
Pubmed	Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells.	RUNX1 RUNX3	3.20e-05	4	81	2	19800266
Pubmed	Inflammation-driven colon neoplasmatogenesis in uPA-deficient mice is associated with an increased expression of Runx transcriptional regulators.	RUNX1 RUNX3	3.20e-05	4	81	2	29107070
Pubmed	A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator.	RUNX1 RUNX3	3.20e-05	4	81	2	10228168
Pubmed	Runt-related transcription factor 3 is associated with ulcerative colitis and shows epistasis with solute carrier family 22, members 4 and 5.	RUNX1 RUNX3	3.20e-05	4	81	2	18668679
Pubmed	Disruption of mouse cytochrome p450 4f14 (Cyp4f14 gene) causes severe perturbations in vitamin E metabolism.	CYP4F8 CYP4F12	3.20e-05	4	81	2	22665481
Pubmed	RUNX represses Pmp22 to drive neurofibromagenesis.	RUNX1 RUNX3	3.20e-05	4	81	2	31032403
Pubmed	Evolution of the interaction between Runx2 and VDR, two transcription factors involved in osteoblastogenesis.	RUNX1 RUNX3	3.20e-05	4	81	2	20236534
Pubmed	Unique N-terminal sequences in two Runx1 isoforms are dispensable for Runx1 function.	RUNX1 RUNX3	3.20e-05	4	81	2	29047338
Pubmed	Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14.	CYP4F8 CYP4F12	3.20e-05	4	81	2	11185557
Pubmed	AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element.	FOS RUNX1	3.20e-05	4	81	2	11274169
Pubmed	Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt+ T cells.	RUNX1 RUNX3	3.20e-05	4	81	2	31818882
Pubmed	Central Role of Core Binding Factor β2 in Mucosa-Associated Lymphoid Tissue Organogenesis in Mouse.	RUNX1 RUNX3	3.20e-05	4	81	2	26001080
Pubmed	Transcription Factors Runx1 and Runx3 Suppress Keratin Expression in Undifferentiated Keratinocytes.	RUNX1 RUNX3	3.20e-05	4	81	2	36077435
Pubmed	Dual color FISH on CBF primary acute myeloid leukemia.	RUNX1 RUNX3	3.20e-05	4	81	2	20306685
Pubmed	The LMO2 -25 Region Harbours GATA2-Dependent Myeloid Enhancer and RUNX-Dependent T-Lymphoid Repressor Activity.	RUNX1 RUNX3	3.20e-05	4	81	2	26161748
Pubmed	Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer.	RUNX1 RUNX3	3.20e-05	4	81	2	17646405
Pubmed	The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells.	RUNX1 RUNX3	3.20e-05	4	81	2	17646406
Pubmed	NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.	RUNX1 RUNX3	3.20e-05	4	81	2	23086478
Pubmed	A dual role for A-type lamins in DNA double-strand break repair.	RAB3GAP1 TP53BP1	3.20e-05	4	81	2	21701264
Pubmed	The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.	RUNX1 RUNX3	3.20e-05	4	81	2	25185713
Pubmed	Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit.	RUNX1 RUNX3	3.20e-05	4	81	2	12807883
Pubmed	Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation.	FOS RUNX1	3.20e-05	4	81	2	11641401
Pubmed	Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function.	RUNX1 RUNX3	3.20e-05	4	81	2	21786422
Pubmed	Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells.	RUNX1 RUNX3	3.20e-05	4	81	2	19917773
Pubmed	Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.	RUNX1 RUNX3	3.20e-05	4	81	2	12464175
Pubmed	ERK activation causes epilepsy by stimulating NMDA receptor activity.	GRIN2B RUNX1	3.20e-05	4	81	2	17972914
Pubmed	Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1.	RUNX1 RUNX3	3.20e-05	4	81	2	8437866
Pubmed	Overexpression of RUNX3 Represses RUNX1 to Drive Transformation of Myelodysplastic Syndrome.	RUNX1 RUNX3	3.20e-05	4	81	2	32341038
Pubmed	Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes.	FOS RUNX1 RUNX3	3.82e-05	28	81	3	27076431
Pubmed	The Tre2 (USP6) oncogene is a hominoid-specific gene.	USP6 USP32	5.33e-05	5	81	2	12604796
Pubmed	Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism.	CYP4F8 CYP4F12	5.33e-05	5	81	2	22969154
Pubmed	Oncogenic Runx1-Myc axis in p53-deficient thymic lymphoma.	RUNX1 RUNX3	5.33e-05	5	81	2	35114276
Pubmed	Runx1 and Runx3 are involved in the generation and function of highly suppressive IL-17-producing T regulatory cells.	RUNX1 RUNX3	5.33e-05	5	81	2	22984619
Pubmed	Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response.	RNF169 TP53BP1	5.33e-05	5	81	2	33022275
Pubmed	Runx3 is required for oncogenic Myc upregulation in p53-deficient osteosarcoma.	RUNX1 RUNX3	5.33e-05	5	81	2	34803166
Pubmed	Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects.	RUNX1 RUNX3	5.33e-05	5	81	2	25066130
Pubmed	Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation.	CYP4F8 CYP4F12	5.33e-05	5	81	2	21466787
Pubmed	RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription.	RUNX1 RUNX3	5.33e-05	5	81	2	16652147
Pubmed	Transcriptional regulation of osteopontin gene in vivo by PEBP2alphaA/CBFA1 and ETS1 in the skeletal tissues.	RUNX1 RUNX3	5.33e-05	5	81	2	9794229
Pubmed	T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt.	RUNX1 RUNX3	5.33e-05	5	81	2	21151104
Pubmed	Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity.	RUNX1 RUNX3	5.33e-05	5	81	2	32218434
Pubmed	Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.	RUNX1 RUNX3	5.33e-05	5	81	2	17377532
Pubmed	Interplay between SOX7 and RUNX1 regulates hemogenic endothelial fate in the yolk sac.	RUNX1 RUNX3	5.33e-05	5	81	2	27802172
Pubmed	Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.	RUNX1 RUNX3	5.33e-05	5	81	2	18258917
Pubmed	The Runx1 transcription factor inhibits the differentiation of naive CD4+ T cells into the Th2 lineage by repressing GATA3 expression.	RUNX1 RUNX3	5.33e-05	5	81	2	12835475
Pubmed	Runx1-Cbfβ facilitates early B lymphocyte development by regulating expression of Ebf1.	RUNX1 RUNX3	5.33e-05	5	81	2	22665574
Pubmed	Epigenetic Thpok silencing limits the time window to choose CD4(+) helper-lineage fate in the thymus.	RUNX1 RUNX3	5.33e-05	5	81	2	23481257
Pubmed	DNA Damage Regulates Translation through β-TRCP Targeting of CReP.	ZNF704 HIVEP1 BTRC	7.55e-05	35	81	3	26091241
Pubmed	Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of 53BP1 Chromatin Recruitment by RNF168/169 and RAD18.	RNF169 TP53BP1	7.99e-05	6	81	2	28506460
Pubmed	Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes.	RUNX1 RUNX3	7.99e-05	6	81	2	28951542
Pubmed	Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene.	RUNX1 RUNX3	7.99e-05	6	81	2	30185787
Pubmed	RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair.	RNF169 TP53BP1	7.99e-05	6	81	2	30104380
Pubmed	RUNX3 suppresses metastasis and stemness by inhibiting Hedgehog signaling in colorectal cancer.	RUNX3 BTRC	7.99e-05	6	81	2	31278361
Pubmed	Runx1 and Cbfβ regulate the development of Flt3+ dendritic cell progenitors and restrict myeloproliferative disorder.	RUNX1 RUNX3	7.99e-05	6	81	2	24677539
Pubmed	The essential requirement for Runx1 in the development of the sternum.	RUNX1 RUNX3	7.99e-05	6	81	2	20152828
Pubmed	The cytochrome P450 4 (CYP4) family.	CYP4F8 CYP4F12	7.99e-05	6	81	2	9068972
Cytoband	1p36.3	MMP23B ARHGEF16	2.76e-04	14	81	2	1p36.3
Cytoband	22q11.21	RIMBP3 RIMBP3C RIMBP3B	1.02e-03	111	81	3	22q11.21
Cytoband	21q22.3	C21orf58 RUNX1 PRDM15	1.54e-03	128	81	3	21q22.3
Cytoband	16p12.2	RBBP6 ERN2	1.97e-03	37	81	2	16p12.2
Cytoband	3p21.1	NEK4 STAB1	2.53e-03	42	81	2	3p21.1
Cytoband	19p13.1	CYP4F8 CYP4F12	3.29e-03	48	81	2	19p13.1
Coexpression	GSE3720_UNSTIM_VS_LPS_STIM_VD2_GAMMADELTA_TCELL_DN	HAVCR2 PIEZO1 PLCB4 ZMIZ1 EXOC3L2 RUNX1	8.11e-06	153	81	6	M6338
Coexpression	TRAVAGLINI_LUNG_EREG_DENDRITIC_CELL	TBXAS1 HAVCR2 FOS USP32 RAB7A ZMIZ1 RUNX1 TYMP MAP2K3 STAB1	1.14e-05	577	81	10	M41697
Coexpression	FLETCHER_PBMC_BCG_10W_INFANT_BCG_STIMULATED_VS_UNSTIMULATED_10W_DN	TBXAS1 HAVCR2 FOS PIEZO1 ZMIZ1 CYTH4 STAB1	1.47e-05	256	81	7	M41152
Coexpression	GSE5099_UNSTIM_VS_MCSF_TREATED_MONOCYTE_DAY3_DN	FOS PIEZO1 FHOD1 MAP2K3 TP53BP1 AHNAK2	3.69e-05	200	81	6	M6583
Coexpression	GSE3982_DC_VS_BCELL_UP	TBXAS1 FHOD1 CYP27B1 USP32 PLXND1 AHNAK2	3.69e-05	200	81	6	M5463
Coexpression	GAO_LARGE_INTESTINE_24W_C6_SECRETORY_PROGENITOR	PLXND1 TYMP STAB1	4.20e-05	22	81	3	M39156
Coexpression	HARALAMBIEVA_PBMC_FLUARIX_AGE_50_74YO_CORR_WITH_28D_MEM_B_CELL_RESPONSE_AT_0DY_NEGATIVE	PPP2R5B PAPLN ZMIZ1 ZNF768 TFE3 AHNAK2 SH3BP4 RPS6KC1	6.02e-05	435	81	8	M41115
Coexpression	MARTENS_BOUND_BY_PML_RARA_FUSION	TBXAS1 FHOD1 PLXND1 ZMIZ1 RUNX1 RUNX3 MAP2K3 CYTH4	8.36e-05	456	81	8	M2094
CoexpressionAtlas	DevelopingKidney_e15.5_stage III -IV renal corpusc_emap-27945_k-means-cluster#3_top-relative-expression-ranked_1000	FHOD1 FGD5 PLXND1 EXOC3L2 STAB1	4.13e-05	103	79	5	gudmap_developingKidney_e15.5_stage III -IV renal corpusc_1000_k3
CoexpressionAtlas	DevelopingKidney_e15.5_stage III -IV renal corpusc_emap-27945_k-means-cluster#1_top-relative-expression-ranked_500	FHOD1 FGD5 PLXND1 EXOC3L2	4.19e-05	52	79	4	gudmap_developingKidney_e15.5_stage III -IV renal corpusc_500_k1
CoexpressionAtlas	DevelopingKidney_e15.5_S-shaped body_emap-27855_k-means-cluster#2_top-relative-expression-ranked_1000	FHOD1 MMP23B FGD5 PLXND1 EXOC3L2 SH3BP4	7.23e-05	188	79	6	gudmap_developingKidney_e15.5_S-shaped body_1000_k2
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP1R3A JCAD HOXB5 FGD5 PLCB4 PLXND1 STAB1	5.73e-08	190	81	7	a08c5929b05a4969852e351a93c4e4deb4c8d5b6
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP1R3A JCAD HOXB5 FGD5 PLCB4 PLXND1 STAB1	5.73e-08	190	81	7	25525fee1da8a808034d9c916159fd0b6b26bce8
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	TBXAS1 HAVCR2 HIVEP1 FHOD1 PLXND1 STAB1	6.84e-07	170	81	6	9ac1ef57f14418a5dd2aa16861c3df698c28f5ed
ToppCell	COVID-19-Heart-CM_+_Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	TBXAS1 FOXD4L1 CPEB4 RBM20 CYTH4 STAB1	6.84e-07	170	81	6	4232fe937909f93d3736988c707b8f95ce993398
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TBXAS1 MISP PLXND1 TYMP CYTH4 STAB1	1.12e-06	185	81	6	76fc5bbb71e42c0eb70474efcd3a71a7b2633f24
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP1R3A JCAD HOXB5 FGD5 PLXND1 STAB1	1.23e-06	188	81	6	0aa8747c2931b0c91f6d78bb2db8fd8ede6dd559
ToppCell	RA-08._Macrophage\|RA / Chamber and Cluster_Paper	TBXAS1 HAVCR2 RUNX1 TYMP CYTH4 STAB1	1.48e-06	194	81	6	ac26e5c71d5069622de72fa25a9c920887ac2c19
ToppCell	COVID-19-lung-Macrophage_CD163hi_MERTKhi\|lung / Disease (COVID-19 only), tissue and cell type	TBXAS1 HAVCR2 RUNX1 TYMP CYTH4 STAB1	1.52e-06	195	81	6	148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCell	COVID-19-lung-Macrophage_CD163hi_MERTKhi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TBXAS1 HAVCR2 RUNX1 TYMP CYTH4 STAB1	1.57e-06	196	81	6	7026c1fc33425e5476063d17c79e4b79356a9e01
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-Myeloid-Macrophages\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TBXAS1 HAVCR2 RUNX3 TYMP CYTH4 STAB1	1.57e-06	196	81	6	fa24d7c4b7c65e98b209db302a16c58ceac1a105
ToppCell	COVID-19-lung-Macrophage_LDB2hi_OSMRhi_YAP1hi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TBXAS1 HAVCR2 RUNX1 TYMP CYTH4 STAB1	1.61e-06	197	81	6	e42910a653a1b5bd90c090e9665a84871ed2873f
ToppCell	Fetal_29-31_weeks-Immune\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TBXAS1 HAVCR2 RUNX1 RUNX3 TYMP CYTH4	1.66e-06	198	81	6	5dff131356b8c22743bd27b2b21f86ee6e4a0a0d
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TBXAS1 HAVCR2 RUNX3 TYMP CYTH4 STAB1	1.66e-06	198	81	6	b226f97c034831d75258214bed9edbad15a501b2
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-Myeloid\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TBXAS1 HAVCR2 RUNX3 TYMP CYTH4 STAB1	1.66e-06	198	81	6	be038619157aeaa7a57ebd66392de940df4f8127
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular-Interstitial_macrophage_perivascular_L.1.2.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TBXAS1 HAVCR2 FOS TYMP CYTH4 STAB1	1.71e-06	199	81	6	4e552015989defc32fe9068e0ba28521b2a1a09c
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-lung_macrophage\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TBXAS1 HAVCR2 FOS TYMP CYTH4 STAB1	1.71e-06	199	81	6	42d57522aa05892f37790d0039d936e065565359
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intermediate\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TBXAS1 HAVCR2 PLXND1 TYMP CYTH4 STAB1	1.71e-06	199	81	6	54167894a16e975d0541cbe3e515bcfa183044f6
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TBXAS1 HAVCR2 RUNX3 TYMP CYTH4 STAB1	1.71e-06	199	81	6	5ceeed92f831d068ff4bb3994f420002338330e7
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Myeloid-Microglia\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	TBXAS1 HAVCR2 PIEZO1 RUNX1 CYTH4 STAB1	1.71e-06	199	81	6	4ddfbcaa8054b69b3398d8c0d5fab8ae94805cb9
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TBXAS1 HAVCR2 FOS TYMP CYTH4 STAB1	1.71e-06	199	81	6	0554f41ae53c275c92fe692bd999d7578d244fce
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Myeloid\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	TBXAS1 HAVCR2 PIEZO1 RUNX1 CYTH4 STAB1	1.71e-06	199	81	6	3ba48a4715d5e9387650aa97e0c5d7f7897bf380
ToppCell	facs-Pancreas-Exocrine-3m-Hematologic-leukocyte\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBXAS1 RUNX1 RUNX3 CYTH4 STAB1	7.54e-06	148	81	5	bbf4933582b50b3412c805de5ed137107c996236
ToppCell	facs-Pancreas-Exocrine-3m-Hematologic-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBXAS1 RUNX1 RUNX3 CYTH4 STAB1	7.54e-06	148	81	5	6543860e3207a7de92a35bb6004be51287582f7a
ToppCell	facs-Pancreas-Exocrine-3m-Hematologic\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBXAS1 RUNX1 RUNX3 CYTH4 STAB1	7.54e-06	148	81	5	79e376503a3f9504a1ec5af4a60a09cc80e19059
ToppCell	primary_visual_cortex-Non-neuronal-macrophage-Macrophage-Microglia_Siglech\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	9.44e-06	155	81	5	f59ca572556c17c606604da1b0331710d4751e54
ToppCell	primary_visual_cortex-Non-neuronal-macrophage-Macrophage\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	9.74e-06	156	81	5	4b6b59a1638a7218a9ed9bd702c04d9f51dbc7aa
ToppCell	primary_visual_cortex-Non-neuronal-macrophage\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	9.74e-06	156	81	5	60a8a8584d3c80c4ceb433cb820de914e33e3500
ToppCell	frontal_cortex-Non-neuronal-macrophage-Macrophage-Microglia_Siglech\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	1.10e-05	160	81	5	c3f2f362e5d0602bb997e8367b4c9a8fe88e4ea8
ToppCell	frontal_cortex-Non-neuronal-macrophage\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	1.20e-05	163	81	5	b89f586b444f90047c8ce407f53847fd1ee7cca3
ToppCell	frontal_cortex-Non-neuronal-macrophage-Macrophage\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	1.20e-05	163	81	5	cbe9b4c4b2e42e9f92a57ed66758af93434db5bb
ToppCell	PND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TBXAS1 HAVCR2 RUNX3 PRDM15 CYTH4	1.20e-05	163	81	5	7af3d3ae7e0de733a18d0486c7ffbb5a7ef7230a
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBXAS1 HAVCR2 RUNX3 CYTH4 RPS6KC1	1.24e-05	164	81	5	54f8f11d2fa899005530c08e7a1ee728c7b0799c
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-cDC2\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TBXAS1 RUNX3 TYMP SHISA8 STAB1	1.31e-05	166	81	5	83d0c26ccee605df6b04bbca31661bf4ff4f22ba
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D175\|Adult / Lineage, Cell type, age group and donor	FGD5 PLCB4 GRIN2B EXOC3L2 JAM3	1.43e-05	169	81	5	e1f0298236e4a1c59077c14f0dd29a78fac12648
ToppCell	facs-Heart-RA-18m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBXAS1 HAVCR2 RUNX1 RUNX3 CYTH4	1.52e-05	171	81	5	15fedb078d93ac4b7fd2945870b50a718f665487
ToppCell	facs-Heart-RA-18m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBXAS1 HAVCR2 RUNX1 RUNX3 CYTH4	1.52e-05	171	81	5	467f53033f172905e653d85aaa6751a00e5d9e10
ToppCell	Bronchial_Biopsy-Immune-Mast_cells\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	TBXAS1 HAVCR2 JCAD RUNX3 STAB1	1.56e-05	172	81	5	c477008444d2d71071177807870d7455e90c2fad
ToppCell	3'-GW_trimst-1-LargeIntestine-Hematopoietic-Myeloid-Macrophages\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TBXAS1 HAVCR2 TYMP CYTH4 STAB1	1.70e-05	175	81	5	fe27c3279f660b5be4193005394b77163c599d32
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_3\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	ZNF704 JCAD MMP23B GATA6 SVEP1	1.74e-05	176	81	5	bfa1633e1b7a8a2f04d37fa07284fe9bc0199f46
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	JCAD FGD5 PLCB4 GRIN2B SH3BP4	1.79e-05	177	81	5	5ff8dcfb030312126695d53a026d2e104a401b83
ToppCell	Posterior_cortex-Hematopoietic\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	1.84e-05	178	81	5	ea9e4f461dda34c0ebc707d7dbefc7a49ce5bb55
ToppCell	Posterior_cortex-Hematopoietic-MICROGLIA\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	1.89e-05	179	81	5	5122fc794509492afde4af8b1b76d51e3070ef05
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD FGD5 PLXND1 EXOC3L2 JAM3	1.89e-05	179	81	5	8f9e538c822940785130297712b75131812a4603
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Hematopoietic-Myeloid\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TBXAS1 HAVCR2 TYMP CYTH4 STAB1	1.99e-05	181	81	5	090e89b506d945e123e647d08947e9649a65ce7c
ToppCell	PBMC-Control-Hematopoietic-HSPC-HSPC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ZNF704 AMHR2 HOXB5 PLCB4 C1QTNF4	2.05e-05	182	81	5	6497eeafb2b137e70261ec0314782831892a940d
ToppCell	PBMC-Control-Hematopoietic-HSPC-HSPC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF704 AMHR2 HOXB5 PLCB4 C1QTNF4	2.05e-05	182	81	5	d0ebf2f0d5370458ab81485a0017c311077133d5
ToppCell	PBMC-Control-Hematopoietic-HSPC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ZNF704 AMHR2 HOXB5 PLCB4 C1QTNF4	2.05e-05	182	81	5	bd1626261803324084fafca2f6665b50854e7fae
ToppCell	PBMC-Control-Hematopoietic-HSPC-HSPC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF704 AMHR2 HOXB5 PLCB4 C1QTNF4	2.05e-05	182	81	5	2a6d1246bfb5899a0861c7f2f8fb9b43b0df8acc
ToppCell	PBMC-Control-Hematopoietic-HSPC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF704 AMHR2 HOXB5 PLCB4 C1QTNF4	2.05e-05	182	81	5	918286422b3eab32d962b49aa07b1b9512e51d9d
ToppCell	PBMC-Control-Hematopoietic-HSPC-HSPC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ZNF704 AMHR2 HOXB5 PLCB4 C1QTNF4	2.05e-05	182	81	5	0d9b8c900da8cbae9cde72aecd4026b1ac2bbd67
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	JCAD FGD5 PLCB4 GRIN2B PLXND1	2.10e-05	183	81	5	c1297d8eddfc7132e84ceef14f01b6281f9d0f6a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD CYP4F8 FGD5 PLXND1 EXOC3L2	2.16e-05	184	81	5	688428103e8b19f45f2f65d70a0f30c904c8411c
ToppCell	PBMC-Severe-Hematopoietic-HSPC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF704 HOXB5 FGD5 PLCB4 C1QTNF4	2.16e-05	184	81	5	a6169613c6493b947a176493f542368bfa935dab
ToppCell	PBMC-Severe-Hematopoietic-HSPC-HSPC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ZNF704 HOXB5 FGD5 PLCB4 C1QTNF4	2.16e-05	184	81	5	51d0447699e3b8f01abbde83f26b748bc9f3c723
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Endothelial_Myeloid-Micro\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.16e-05	184	81	5	371c1927ac06b77ff462a94cca6acb802f9724ff
ToppCell	PBMC-Severe-Hematopoietic-HSPC-HSPC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ZNF704 HOXB5 FGD5 PLCB4 C1QTNF4	2.16e-05	184	81	5	f7b0bb45a9055ab34e98b251217f6ec38c75ca22
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia-Micro_L1-6_C1QC\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.16e-05	184	81	5	fbac70333e4f028bfbdd9cc9401427caac9f0c47
ToppCell	PBMC-Severe-Hematopoietic-HSPC-HSPC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF704 HOXB5 FGD5 PLCB4 C1QTNF4	2.16e-05	184	81	5	cc01c19180861f491a8dc16d60fabd1215fc4525
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.16e-05	184	81	5	dd6777a0cb49cd79fc439920c3c930a1e4681bb0
ToppCell	PBMC-Severe-Hematopoietic-HSPC-HSPC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF704 HOXB5 FGD5 PLCB4 C1QTNF4	2.16e-05	184	81	5	492c680f0769ba4e651d09c2e8e5d5d271ed08aa
ToppCell	PBMC-Severe-Hematopoietic-HSPC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	ZNF704 HOXB5 FGD5 PLCB4 C1QTNF4	2.16e-05	184	81	5	26edbf84216538b80f1ffcc079ee6e385a71fbf9
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Endothelial_Myeloid\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.21e-05	185	81	5	6b832b3e080dfadd21253ac45022192f4d3cb37b
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.27e-05	186	81	5	e41f14aee8cfbf76b8d0d4695a6170e2cd92aec8
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia-Micro_L1-6_C1QC\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.27e-05	186	81	5	b3633cd4e360c5b45060c50b4f606d483e03a89a
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Endothelial_Myeloid-Micro\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.27e-05	186	81	5	9dd31dc9af1704f35c74de726a6c27fa21e9a014
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Endothelial_Myeloid\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.33e-05	187	81	5	23a42c172d5cc36cb8793c0bc2ce357c6c8e5d39
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Endothelial_Myeloid\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.33e-05	187	81	5	5ce7cf02990465b6f793205e4be07e8337b3570a
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia-Micro_L1-6_C1QC\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.33e-05	187	81	5	17a37fc3a1d62fef3137e5ff26a84c0b8c80e124
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Endothelial_Myeloid-Micro\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.33e-05	187	81	5	1b0eb29394040555516677b9de75c15e769c4c53
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.33e-05	187	81	5	11c773cf3dc1e725b7e4d8edd676c8a94a231d2a
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TBXAS1 HAVCR2 TYMP CYTH4 STAB1	2.39e-05	188	81	5	3be2d50148daa4eddddc2c7f269f45c97f7e4931
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.39e-05	188	81	5	26c0a94951236a5d17a169920b0a8a9d0dd7d0ed
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia-Micro_L1-6_C1QC\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.39e-05	188	81	5	af300574c4e95505f56bf716bcee1e4777944e8e
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.39e-05	188	81	5	5df5a0890e17d19f55770525345a656253696887
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Endothelial_Myeloid\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.39e-05	188	81	5	c65fb9a3c910dd6166853f4f3a2f2c2411ccf03b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Endothelial_Myeloid-Micro\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.39e-05	188	81	5	e169e9bb85892e52880ee949d0f691d0ea0c8dc9
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia-Micro_L1-6_C1QC\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.39e-05	188	81	5	9e923b0d79495ee1a3a097741a877f25d439eda3
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Endothelial_Myeloid-Micro\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.39e-05	188	81	5	14dbc985abc2012c9f53deb243d465e4175f419f
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia-Micro_L1-6_C1QC\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.45e-05	189	81	5	389ccb68acb82893709f256315111470cf4beed3
ToppCell	COVID-19_Severe-HSPC\|World / disease group, cell group and cell class	ZNF704 HOXB5 FGD5 PLCB4 C1QTNF4	2.45e-05	189	81	5	555c0b13f1508b9e3712b36d77144e73e828bc76
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Endothelial_Myeloid-Micro-Microglia\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.45e-05	189	81	5	58465b9407fbce91cca8f199950d6e0054c38fbc
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Endothelial_Myeloid\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.45e-05	189	81	5	e9fe8d17f4b7cca9bbf3655047e27b2fec5060c1
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Endothelial_Myeloid-Micro\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.45e-05	189	81	5	7ac78441a15a82218deaafd47accff2ea5c8de20
ToppCell	Fetal_29-31_weeks-Immune-monocyte-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TBXAS1 HAVCR2 RUNX3 TYMP CYTH4	2.52e-05	190	81	5	ad297172a74a80ed5c10f921e15efd1da0fd2d6b
ToppCell	(2)_5-FU-(1)_VE-Cad+_vascular_cells\|World / Stress and Cell class	JCAD PIEZO1 FGD5 PLXND1 STAB1	2.52e-05	190	81	5	6b391b8a3ffcbdec3acaf242bc52fc3fc9da77c8
ToppCell	21-Trachea-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	JCAD AMHR2 PLXND1 EXOC3L2 STAB1	2.52e-05	190	81	5	bce09634acbc2cfd53666328e8aed8bf8835f845
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	JCAD FGD5 PLCB4 JAM3 SH3BP4	2.52e-05	190	81	5	0e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Endothelial_Myeloid\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBXAS1 HAVCR2 RUNX1 CYTH4 STAB1	2.52e-05	190	81	5	d4f954e0748898df69e1710df558564db703dd61
ToppCell	Dendritic_cell\|World / shred by cell class for nasal brushing	TBXAS1 HAVCR2 PLXND1 CYTH4 STAB1	2.52e-05	190	81	5	ae24934f45eea9c228bf6fe8cd0d6abca9eb208e
ToppCell	21-Trachea-Endothelial-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	JCAD AMHR2 PLXND1 EXOC3L2 STAB1	2.52e-05	190	81	5	08437396a98ca9526f69c3a74bbf2929f3c68b8e
ToppCell	Dendritic_Cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	TBXAS1 HAVCR2 RUNX3 CYTH4 STAB1	2.58e-05	191	81	5	b51c8ff1279581088557bb36760c70209c77148c
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TBXAS1 MISP PLXND1 TYMP STAB1	2.58e-05	191	81	5	79e7089022063c5f2b2f1b27658c62b741f3a037
ToppCell	droplet-Heart\|droplet / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JCAD GATA6 FGD5 PLXND1 STAB1	2.65e-05	192	81	5	67a7e07a11091120edbccf739836235c422ec9c6
ToppCell	LV-08._Macrophage\|LV / Chamber and Cluster_Paper	TBXAS1 RUNX1 TYMP CYTH4 STAB1	2.65e-05	192	81	5	7be12d580aaf2f2f1562203fcad3a44639b8c5a6
ToppCell	18-Distal-Immune-Hematopoietic,_Macrophage\|Distal / Age, Tissue, Lineage and Cell class	TBXAS1 HAVCR2 TYMP CYTH4 STAB1	2.65e-05	192	81	5	e54577183b09599a3b2bdd532a18ea8f4a6e3524
ToppCell	15-Trachea-Endothelial-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	JCAD GATA6 FGD5 PLXND1 STAB1	2.71e-05	193	81	5	6ea0444fc3dc156997129387184e6418947f4b12
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP1R3A JCAD FGD5 PLXND1 STAB1	2.71e-05	193	81	5	826b8dd801298b3e0cd76232feae5a14026b8806
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP1R3A JCAD FGD5 PLXND1 STAB1	2.71e-05	193	81	5	87d3a577d37fb0cb4b6313c596310de452bc3872
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TBXAS1 FOS PLXND1 TYMP STAB1	2.71e-05	193	81	5	1db487e5f81849740d57cc3e2b5739e8f7581efb
ToppCell	15-Trachea-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	JCAD GATA6 FGD5 PLXND1 STAB1	2.71e-05	193	81	5	b1ebf8df2d55e2938e5a495ea68b80c4ac216dc0
Drug	Fipexide hydrochloride [34161-23-4]; Down 200; 9.4uM; PC3; HT_HG-U133A	VPS13D PPP2R5B CYP27B1 FRS3 PLXND1 RUNX1 ZNF768 SVEP1	3.96e-07	198	78	8	5737_DN
Drug	(Z)-7-[(1S,4R,6R)-5-[(E)-oct-1-enyl]-2,3-diazabicyclo[2.2.1]hept-2-en-6-yl]hept-5-enoic acid	TBXAS1 CYP4F8 CYP4F12	4.56e-06	10	78	3	CID009905657
Drug	Estrone [53-16-7]; Down 200; 14.8uM; PC3; HT_HG-U133A	HOXB5 CYP27B1 FRS3 RUNX1 RUNX3 ARHGEF16 BTRC	4.64e-06	194	78	7	6647_DN
Drug	Acacetin [480-44-4]; Down 200; 14uM; PC3; HT_HG-U133A	HOXB5 PPP2R5B FHOD1 TJAP1 RUNX1 RUNX3 ERN2	4.80e-06	195	78	7	4324_DN
Drug	THIP Hydrochloride; Down 200; 22.6uM; HL60; HT_HG-U133A	VPS13D PIEZO1 CYP27B1 FRS3 TJAP1 ERN2 BTRC	5.13e-06	197	78	7	3132_DN
Drug	Mianserine hydrochloride [21535-47-7]; Down 200; 13.2uM; PC3; HT_HG-U133A	HOXB5 FHOD1 FRS3 RUNX3 ERN2 ARHGEF16 JAM3	5.30e-06	198	78	7	5786_DN
Drug	Scopoletin [92-61-5]; Down 200; 20.8uM; HL60; HT_HG-U133A	RAB3GAP1 PIEZO1 CYP27B1 PLXND1 RUNX1 TYMP MAP2K3	5.30e-06	198	78	7	3131_DN
Drug	azo analog I	TBXAS1 CYP4F8 CYP4F12	1.08e-05	13	78	3	CID006438575
Drug	Pyrvinium pamoate [3546-41-6]; Up 200; 3.4uM; HL60; HT_HG-U133A	MISP FOS GRAMD2B RUNX1 TYMP MAP2K3	2.70e-05	171	78	6	2957_UP
Drug	Propofol [2078-54-8]; Up 200; 22.4uM; MCF7; HT_HG-U133A	JCAD HOXB5 EGR4 FOS RUNX1 STAB1	4.46e-05	187	78	6	3386_UP
Drug	Dihydrostreptomycin sulfate [5490-27-7]; Down 200; 2.8uM; PC3; HT_HG-U133A	HOXB5 CYP27B1 RUNX1 ERN2 BTRC SVEP1	5.79e-05	196	78	6	5751_DN
Drug	Tetrahydroalstonine [6474-90-4]; Down 200; 11.4uM; PC3; HT_HG-U133A	HOXB5 RUNX1 RUNX3 ERN2 ZNF768 SVEP1	5.79e-05	196	78	6	5728_DN
Drug	Trimipramine maleate salt [521-78-8]; Down 200; 9.8uM; PC3; HT_HG-U133A	HOXB5 PPP2R5B RUNX1 ARHGEF16 ZNF768 BTRC	5.79e-05	196	78	6	4083_DN
Drug	Tetracycline hydrochloride [64-75-5]; Down 200; 8.4uM; PC3; HT_HG-U133A	JCAD PPP2R5B HIVEP1 RUNX1 ERN2 SVEP1	5.79e-05	196	78	6	5757_DN
Drug	Fludrocortisone acetate [514-36-3]; Up 200; 9.4uM; PC3; HT_HG-U133A	CYP4F12 PLXND1 RUNX1 TYMP CYTH4 STAB1	5.79e-05	196	78	6	4342_UP
Drug	Dropropizine (R,S) [17692-31-8]; Up 200; 17uM; PC3; HT_HG-U133A	HOXB5 FRS3 TJAP1 PLXND1 RUNX3 ERN2	5.95e-05	197	78	6	5106_UP
Drug	Mephenytoin [50-12-4]; Down 200; 18.4uM; PC3; HT_HG-U133A	HOXB5 CNKSR1 VPS13D FRS3 RUNX1 ERN2	5.95e-05	197	78	6	5801_DN
Drug	Phenformin hydrochloride [834-28-6]; Down 200; 16.6uM; HL60; HT_HG-U133A	TBXAS1 RC3H2 ACTR5 PLCB4 ERN2 MAP2K3	5.95e-05	197	78	6	2350_DN
Drug	Dizocilpine maleate [77086-22-7]; Down 200; 11.8uM; PC3; HT_HG-U133A	HOXB5 RAB3GAP1 VPS13D FRS3 BTRC SVEP1	5.95e-05	197	78	6	5746_DN
Drug	Nitrendipine [39562-70-4]; Down 200; 11uM; PC3; HT_HG-U133A	CNKSR1 VPS13D PPP2R5B PIEZO1 CYP27B1 RUNX3	6.12e-05	198	78	6	6304_DN
Drug	Articaine hydrochloride [23964-57-0]; Down 200; 12.4uM; PC3; HT_HG-U133A	JCAD RC3H2 MISP PIEZO1 RUNX3 ERN2	6.12e-05	198	78	6	7272_DN
Drug	Tocainide hydrochloride; Up 200; 17.4uM; HL60; HT_HG-U133A	PPP2R5B ACTR5 FRS3 TYMP MAP2K3 ZNF768	6.29e-05	199	78	6	2931_UP
Drug	haloperidol; Down 200; 10uM; MCF7; HT_HG-U133A	RC3H2 RAB3GAP1 VPS13D ACTR5 RUNX1 ZNF768	6.29e-05	199	78	6	6963_DN
Drug	Iohexol [66108-95-0]; Up 200; 4.8uM; MCF7; HT_HG-U133A	VPS13D PPP2R5B PIEZO1 FHOD1 RUNX1 ZNF768	6.47e-05	200	78	6	3322_UP
Drug	2-Chloropyrazine [14508-49-7]; Down 200; 35uM; PC3; HT_HG-U133A	CYP27B1 FRS3 RUNX1 ZNF768 BTRC SVEP1	6.47e-05	200	78	6	5750_DN
Drug	chloral hydrate	CYP4F8 FOS CYP27B1 CYP4F12 GRIN2B	8.19e-05	129	78	5	CID000002707
Disease	eosinophil count	PPP1R3A TBXAS1 HIVEP1 CYP27B1 CPEB4 RAB7A TNKS1BP1 EXOC3L2 RUNX1 RUNX3 ERN2 SVEP1 C17orf58 TP53BP1	2.35e-05	1488	76	14	EFO_0004842
Disease	retinal disease (implicated_via_orthology)	PLCB4 MAP2K3	9.75e-05	6	76	2	DOID:5679 (implicated_via_orthology)
Disease	hematocrit	JCAD HIVEP1 AOC1 PIEZO1 GRAMD2B FGD5 EXOC3L2 RUNX1 TP53BP1 STAB1	2.62e-04	1011	76	10	EFO_0004348
Disease	QRS amplitude, QRS complex	HIVEP1 CPEB4 RBM20	2.95e-04	50	76	3	EFO_0005054, EFO_0007742
Disease	nicotine dependence symptom count, depressive symptom measurement	GMNC AOC1 GRIN2B	9.70e-04	75	76	3	EFO_0007006, EFO_0009262
Disease	response to methotrexate, juvenile idiopathic arthritis	ZMIZ1 CYTH4	1.09e-03	19	76	2	EFO_0002609, GO_0031427
Disease	Glioblastoma	RUNX1 RUNX3 TP53BP1	1.13e-03	79	76	3	C0017636
Disease	cardiovascular disease	HOXB5 CYP27B1 CPEB4 FGD5 C1QTNF4 SVEP1	1.17e-03	457	76	6	EFO_0000319
Disease	Congenital diaphragmatic hernia	KCNQ5 GATA6	1.33e-03	21	76	2	C0235833
Disease	Giant Cell Glioblastoma	RUNX1 RUNX3 TP53BP1	1.35e-03	84	76	3	C0334588
Disease	cervical squamous cell carcinoma (is_marker_for)	FOS TYMP	1.46e-03	22	76	2	DOID:3744 (is_marker_for)
Disease	colorectal cancer, hormone replacement therapy	PPP1R3A HIVEP1 GRIN2B	1.54e-03	88	76	3	EFO_0003961, MONDO_0005575
Disease	obsolete Mendelian syndromes with cleft lip/palate	JCAD SH3BP4	1.60e-03	23	76	2	MONDO_0015335
Disease	lymphocyte percentage of leukocytes	HIVEP1 AOC1 TMTC3 CYP27B1 RAB7A ZMIZ1 EXOC3L2	1.63e-03	665	76	7	EFO_0007993
Disease	red blood cell density measurement	ZNF704 HIVEP1 TMTC3 PIEZO1 CPEB4 FGD5 EXOC3L2 RUNX1	1.91e-03	880	76	8	EFO_0007978
Disease	energy expenditure	TBXAS1 CDHR3	2.20e-03	27	76	2	EFO_0005109
Disease	colorectal adenocarcinoma (is_marker_for)	FOS RUNX1	2.20e-03	27	76	2	DOID:0050861 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
NIFRTLPPSENPEFD	PPP2R5B	136	Q15173
QLFPDTSTPRPFRFA	AGBL5	226	Q8NDL9
DRAFFADIPVPRPSF	EXOC3L2	356	Q2M3D2
DFLNDPAAQAEPPRS	BTRC	581	Q9Y297
SPRVRDDAAFQPQVP	ARHGEF16	41	Q5VV41
APPEPRSAFSAARTR	C1QTNF4	171	Q9BXJ3
FPFRDARAAPDPVLE	ACTR5	6	Q9H9F9
NPNVRDRPPFERFVS	CYTH4	201	Q9UIA0
LRPFNFFPEDPSLAS	AOC1	696	P19801
EAPPNRRTCVFFEAP	AMHR2	16	Q16671
PPSPLFSVDFRADFS	RC3H2	806	Q9HBD1
PAEERARQPSPFVDD	RBM20	1051	Q5T481
EERRQNSVSDFPPPA	RAB3GAP1	921	Q15042
FLIQASPRDPENFPF	RAB7A	106	P51149
FFEEPPRRQSPVSNL	RIMBP3B	1246	A6NNM3
FFEEPPRRQSPVSNL	RIMBP3C	1246	A6NJZ7
SRDPAQFPEPNSFRP	CYP27B1	416	O15528
RNALFPEVFSPTPDE	MISP	566	Q8IVT2
RPFFEEAAAEVPSPD	MAGEE1	711	Q9HCI5
TEPFDDFLFPASSRP	FOS	266	P01100
KFFPNDDPEAVSSPR	RPS6KC1	571	Q96S38
PPPADNQASFREAAR	C17orf58	81	Q2M2W7
ETRPPENTQAPAFFL	ERN2	386	Q76MJ5
RPAPADVPRVSTDAF	JCAD	1131	Q9P266
FDAAPQPAREAAFAS	KCNQ5	886	Q9NR82
RRFPSPTPTNNFALD	PLXND1	51	Q9Y4D7
DLFAFQESPPRFLPS	NEK4	556	P51957
RVESFEDRSRPPFLP	FGD5	741	Q6ZNL6
EAAASRSPLDAPFPA	EGR4	221	Q05215
NDVPLPTDSRANPRF	JAM3	176	Q9BX67
PPEPERPRFAAFTAT	GPR78	161	Q96P69
PRPSANRENFSPERF	RBBP6	851	Q7Z6E9
VRSERPFFSSNPELD	MEIS3P2	116	A8K0S8
RDERNTFSTDPVNFP	PPP1R3A	336	Q16821
ESSRAFPAPAQEPRF	HOXB5	71	P09067
FPAPAQEPRFRQAAS	HOXB5	76	P09067
AAAPPTRAPTRRFSD	FAM189B	451	P81408
ASDSRAFPAREPSTP	GATA6	21	Q92908
APAEQFFPASNRTRE	C21orf58	51	P58505
TSPENEFPLIFDRPS	CDHR3	451	Q6ZTQ4
SPRVFNFDFRRPGPE	FRS3	396	O43559
DPFRFDPENAQKRSP	CYP4F8	441	P98187
DPFRFDPENSKGRSP	CYP4F12	441	Q9HCS2
DPSEFGTEFRAPPRS	FOXD4L1	81	Q9NU39
NRADNIFPFPDRPRT	CPEB4	366	Q17RY0
TDPFACANFPEPRRA	FHOD1	26	Q9Y613
PNPSSAENSFRADRP	GRAMD2B	226	Q96HH9
SPQLPADRFSPEFVD	MAP2K3	286	P46734
TAPDLTAFSDPRQFP	RUNX1	296	Q01196
PFSDPRQFDRSFPTL	RUNX3	241	Q13761
RRPDRTFDPFSETPV	PLCB4	681	Q15147
SPAPEQFQSREDFRT	SH3BP4	271	Q9P0V3
PRRVASTFSQFPDDA	GMNC	216	A6NCL1
PFSFREVAPEQPSDL	MMP23B	126	O75900
FFEEPPRRQSPVSNL	RIMBP3	1246	Q9UFD9
AAQFPERIATRSPDP	PRDM15	11	P57071
PAPTRQRDFTAAFPR	HAVCR2	136	Q8TDQ0
DFCQRFPALEPSPRQ	SHISA8	276	B8ZZ34
RAAPAEPDFIFRAPI	RNF169	161	Q8NCN4
PSRNFSFRLFPETAP	SVEP1	26	Q4LDE5
VPRFSFPAPSSEDDV	AHNAK2	5391	Q8IVF2
APLSPRAPSEDVFAF	CNKSR1	311	Q969H4
RAFVDRTPPPAAVAQ	TJAP1	416	Q5JTD0
PSPETFNPERFTAEA	TBXAS1	446	P24557
PSQPEESDVFLRAPF	nan	156	Q6ZSR9
RERREQAAAAPFPSP	TFE3	131	P19532
FERPPASVSRNARPE	SPEM2	321	Q0P670
ELSRFPQPRDPAQDF	PAPLN	1006	O95428
PAPFRPASERFAATT	TNKS1BP1	146	Q9C0C2
SPRFEPESPGFESRS	ZNF768	76	Q9H5H4
PTDAAFRALPPDRQA	STAB1	1766	Q9NY15
DLVAPSPDAFRSTPF	TP53BP1	361	Q12888
ADSFKPFRSPAQPDD	ZNF704	151	Q6ZNC4
AVPEDPRPSAQSAFQ	PIEZO1	1431	Q92508
RFDNPAAVSPTPTRQ	TMTC3	266	Q6ZXV5
LPATPAESPAQRFEA	SUDS3	241	Q9H7L9
LSDRAPFAAPSPFAE	TYMP	461	P19971
NSFDKPEPFERASPV	HIVEP1	1146	P15822
PEPFERASPVSFQEL	HIVEP1	1151	P15822
RESFDPSAFLVPRDP	USP6	1101	P35125
FPRESFDPSAFLVPR	USP32	1301	Q8NFA0
RPPADFTQPAAAAAA	ZMIZ1	271	Q9ULJ6
SFSDTDQLPPPFRID	VPS13D	3506	Q5THJ4
FNKPSRVPAPEAFRD	MYORG	301	Q6NSJ0
FQRPNDFSPPFRFGT	GRIN2B	671	Q13224