Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	regulation of protein localization to synapse	CACNA2D2 NLGN2 NLGN1	1.00e-04	38	49	3	GO:1902473
GeneOntologyBiologicalProcess	positive regulation of synaptic vesicle clustering	NLGN2 NLGN1	1.53e-04	8	49	2	GO:2000809
GeneOntologyBiologicalProcess	positive regulation of protein localization to synapse	NLGN2 NLGN1	1.53e-04	8	49	2	GO:1902474
GeneOntologyBiologicalProcess	terminal button organization	NLGN2 NLGN1	1.97e-04	9	49	2	GO:0072553
GeneOntologyBiologicalProcess	RISC complex assembly	AGO4 ADAR	2.46e-04	10	49	2	GO:0070922
GeneOntologyBiologicalProcess	presynaptic membrane assembly	NLGN2 NLGN1	2.46e-04	10	49	2	GO:0097105
GeneOntologyBiologicalProcess	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	CDH26 NLGN1 CDH12	2.71e-04	53	49	3	GO:0016339
GeneOntologyBiologicalProcess	postsynaptic density protein 95 clustering	NLGN2 NLGN1	3.00e-04	11	49	2	GO:0097119
GeneOntologyBiologicalProcess	postsynaptic membrane assembly	NLGN2 NLGN1	3.00e-04	11	49	2	GO:0097104
GeneOntologyBiologicalProcess	regulation of synaptic vesicle clustering	NLGN2 NLGN1	3.59e-04	12	49	2	GO:2000807
Domain	Nlgn	NLGN2 NLGN1	6.71e-05	5	49	2	IPR000460
Domain	Carboxylesterase_B_CS	NLGN2 NLGN1	5.16e-04	13	49	2	IPR019819
Domain	CARBOXYLESTERASE_B_2	NLGN2 NLGN1	6.01e-04	14	49	2	PS00941
Domain	COesterase	NLGN2 NLGN1	6.01e-04	14	49	2	PF00135
Domain	CarbesteraseB	NLGN2 NLGN1	6.01e-04	14	49	2	IPR002018
Domain	SH3_2	MPP2 ARHGEF37 RUSC2	1.49e-03	86	49	3	IPR011511
Domain	SH3_2	MPP2 ARHGEF37 RUSC2	1.49e-03	86	49	3	PF07653
Domain	SH3	MPP2 PRAM1 ARHGEF37 RUSC2	2.45e-03	216	49	4	SM00326
Domain	SH3	MPP2 PRAM1 ARHGEF37 RUSC2	2.45e-03	216	49	4	PS50002
Domain	SH3_domain	MPP2 PRAM1 ARHGEF37 RUSC2	2.62e-03	220	49	4	IPR001452
Domain	Cadherin_CS	CDH26 CELSR3 CDH12	2.93e-03	109	49	3	IPR020894
Domain	CADHERIN_1	CDH26 CELSR3 CDH12	3.24e-03	113	49	3	PS00232
Domain	Cadherin	CDH26 CELSR3 CDH12	3.24e-03	113	49	3	PF00028
Domain	CADHERIN_2	CDH26 CELSR3 CDH12	3.33e-03	114	49	3	PS50268
Domain	-	CDH26 CELSR3 CDH12	3.33e-03	114	49	3	2.60.40.60
Domain	CA	CDH26 CELSR3 CDH12	3.41e-03	115	49	3	SM00112
Domain	Cadherin-like	CDH26 CELSR3 CDH12	3.49e-03	116	49	3	IPR015919
Domain	Cadherin	CDH26 CELSR3 CDH12	3.67e-03	118	49	3	IPR002126
Domain	-	AGO4 POLE	6.76e-03	47	49	2	3.30.420.10
Pubmed	Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons.	NLGN2 NLGN1	2.11e-06	2	51	2	10892652
Pubmed	Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons.	NLGN2 NLGN1	2.11e-06	2	51	2	19889999
Pubmed	NLGN1 and NLGN2 in the prefrontal cortex: their role in memory consolidation and strengthening.	NLGN2 NLGN1	2.11e-06	2	51	2	29278843
Pubmed	Developmental expression and subcellular distribution of synaptotagmin 11 in rat hippocampus.	NLGN2 NLGN1	6.32e-06	3	51	2	22960622
Pubmed	Unique versus Redundant Functions of Neuroligin Genes in Shaping Excitatory and Inhibitory Synapse Properties.	NLGN2 NLGN1	6.32e-06	3	51	2	28607166
Pubmed	Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits.	NLGN2 NLGN1	6.32e-06	3	51	2	29100073
Pubmed	Synaptic Adhesion Molecules Regulate the Integration of New Granule Neurons in the Postnatal Mouse Hippocampus and their Impact on Spatial Memory.	NLGN2 NLGN1	6.32e-06	3	51	2	27473321
Pubmed	Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses.	NLGN2 NLGN1	6.32e-06	3	51	2	26291161
Pubmed	Neuroligin-3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses.	NLGN2 NLGN1	6.32e-06	3	51	2	17897391
Pubmed	Neuroligins determine synapse maturation and function.	NLGN2 NLGN1	6.32e-06	3	51	2	16982420
Pubmed	Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2.	NLGN2 NLGN1	6.32e-06	3	51	2	17582332
Pubmed	Conditional ablation of neuroligin-1 in CA1 pyramidal neurons blocks LTP by a cell-autonomous NMDA receptor-independent mechanism.	NLGN2 NLGN1	6.32e-06	3	51	2	27217145
Pubmed	Gene expression analysis of the embryonic subplate.	GSPT2 RORB IDE EPAS1 CDH12	1.03e-05	196	51	5	21862448
Pubmed	Autism-related deficits via dysregulated eIF4E-dependent translational control.	NLGN2 NLGN1	1.26e-05	4	51	2	23172145
Pubmed	Neuroligin 2 regulates absence seizures and behavioral arrests through GABAergic transmission within the thalamocortical circuitry.	NLGN2 NLGN1	1.26e-05	4	51	2	32719346
Pubmed	Neuroligin 1, 2, and 3 Regulation at the Synapse: FMRP-Dependent Translation and Activity-Induced Proteolytic Cleavage.	NLGN2 NLGN1	1.26e-05	4	51	2	30056576
Pubmed	Neuroligins Are Selectively Essential for NMDAR Signaling in Cerebellar Stellate Interneurons.	NLGN2 NLGN1	2.10e-05	5	51	2	27581450
Pubmed	Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins.	NLGN2 NLGN1	2.10e-05	5	51	2	15620359
Pubmed	Neuroligin-induced presynaptic differentiation through SLM2-mediated splicing modifications of neurexin in cerebellar cultures.	NLGN2 NLGN1	2.10e-05	5	51	2	28939043
Pubmed	Synapse formation: if it looks like a duck and quacks like a duck ...	NLGN2 NLGN1	2.10e-05	5	51	2	10996085
Pubmed	Interaction between autism-linked MDGAs and neuroligins suppresses inhibitory synapse development.	NLGN2 NLGN1	2.10e-05	5	51	2	23358245
Pubmed	5-HT modulation of a medial septal circuit tunes social memory stability.	NLGN2 NLGN1	2.10e-05	5	51	2	34616037
Pubmed	Multiple N-linked glycosylation sites critically modulate the synaptic abundance of neuroligin isoforms.	NLGN2 NLGN1	2.10e-05	5	51	2	37865312
Pubmed	The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?	NLGN2 NLGN1	3.15e-05	6	51	2	21838267
Pubmed	Structures, alternative splicing, and neurexin binding of multiple neuroligins.	NLGN2 NLGN1	3.15e-05	6	51	2	8576240
Pubmed	Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses.	NLGN2 NLGN1	3.15e-05	6	51	2	29724786
Pubmed	Impairment of Inhibitory Synapse Formation and Motor Behavior in Mice Lacking the NL2 Binding Partner LHFPL4/GARLH4.	NLGN2 NLGN1	3.15e-05	6	51	2	29742426
Pubmed	Dystroglycan is a scaffold for extracellular axon guidance decisions.	CELSR3 ROBO1	3.15e-05	6	51	2	30758284
Pubmed	Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn.	NLGN2 NLGN1	3.15e-05	6	51	2	19816407
Pubmed	Control of excitatory and inhibitory synapse formation by neuroligins.	NLGN2 NLGN1	5.87e-05	8	51	2	15681343
Pubmed	Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.	NLGN2 NLGN1	5.87e-05	8	51	2	30871858
Pubmed	Molecular self-avoidance in synaptic neurexin complexes.	NLGN2 NLGN1	7.54e-05	9	51	2	34919427
Pubmed	Binding of neuroligins to PSD-95.	NLGN2 NLGN1	7.54e-05	9	51	2	9278515
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CEP350 CELSR3 ROBO1 C1S RORB TMEM131 CABIN1 ST18 STAT6	9.36e-05	1285	51	9	35914814
Pubmed	Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors.	RORB NLGN2 EPAS1	9.58e-05	60	51	3	32027825
Pubmed	SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.	NLGN2 NLGN1	1.15e-04	11	51	2	32973045
Pubmed	Behavioral phenotypes of genetic mouse models of autism.	NLGN2 NLGN1	1.15e-04	11	51	2	26403076
Pubmed	SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neurons.	SOX5 RORB	1.63e-04	13	51	2	18840685
Pubmed	Translational animal models of autism and neurodevelopmental disorders.	NLGN2 NLGN1	1.90e-04	14	51	2	23226954
Pubmed	Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism.	NLGN2 NLGN1	2.19e-04	15	51	2	18227507
Pubmed	SOX5 controls the sequential generation of distinct corticofugal neuron subtypes.	SOX5 RORB	2.19e-04	15	51	2	18215621
Pubmed	Loss of transforming growth factor-beta 2 leads to impairment of central synapse function.	NLGN2 NLGN1	3.18e-04	18	51	2	18854036
Pubmed	IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α.	NLGN2 NLGN1	3.18e-04	18	51	2	28864826
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	STARD9 SEL1L3 NLGN1 ST18 RUSC2	3.23e-04	407	51	5	12693553
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	MPP2 FLNC CELSR3 ADAR	3.71e-04	231	51	4	36597993
Pubmed	Neuronal basic helix-loop-helix proteins Neurod2/6 regulate cortical commissure formation before midline interactions.	SOX5 ROBO1	4.35e-04	21	51	2	23303943
Pubmed	Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways.	ROBO1 RORB	5.23e-04	23	51	2	15229646
Pubmed	Type II cadherins guide assembly of a direction-selective retinal circuit.	CDH26 CDH12	5.70e-04	24	51	2	25126785
Pubmed	HNF1B controls epithelial organization and cell polarity during ureteric bud branching and collecting duct morphogenesis.	CDH26 GFRA1	6.19e-04	25	51	2	29158444
Pubmed	Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring.	ROBO1 CDH12	6.70e-04	26	51	2	39152101
Pubmed	DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors.	NLGN2 NLGN1	6.70e-04	26	51	2	34848499
Pubmed	Lamination of the cerebral cortex is disturbed in Gli3 mutant mice.	SOX5 RORB	7.23e-04	27	51	2	18448089
Pubmed	Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.	SOX5 RORB	8.35e-04	29	51	2	20615956
Pubmed	Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex.	SOX5 ROBO1 RORB	8.52e-04	126	51	3	16284245
Pubmed	Genetic interplay between the transcription factors Sp8 and Emx2 in the patterning of the forebrain.	ROBO1 RORB	8.93e-04	30	51	2	17470284
Pubmed	Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex.	NLGN2 NLGN1	8.93e-04	30	51	2	16186258
Pubmed	A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.	POLE NONO	9.54e-04	31	51	2	12171929
Pubmed	Placing the HIRA histone chaperone complex in the chromatin landscape.	CABIN1 POLR3A	9.54e-04	31	51	2	23602572
Pubmed	Immunosuppressive lncRNA LINC00624 promotes tumor progression and therapy resistance through ADAR1 stabilization.	ADAR NONO	1.02e-03	32	51	2	36252997
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	FLNC GLDC IDE ATXN1L	1.04e-03	304	51	4	32235678
Pubmed	Transcription factors Bcl11a and Bcl11b are required for the production and differentiation of cortical projection neurons.	SOX5 RORB	1.15e-03	34	51	2	34963132
Pubmed	Regulation of prefrontal patterning and connectivity by retinoic acid.	ROBO1 RORB	1.15e-03	34	51	2	34599305
Pubmed	The Gli3 hypomorphic mutation Pdn causes selective impairment in the growth, patterning, and axon guidance capability of the lateral ganglionic eminence.	SOX5 RORB	1.22e-03	35	51	2	20943929
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	SOX5 FLAD1 NONO ERVFRD-1 RUSC2	1.36e-03	560	51	5	21653829
Pubmed	Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline.	ROBO1 RORB	1.43e-03	38	51	2	18579678
Pubmed	Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.	EPAS1 ERVFRD-1	1.43e-03	38	51	2	27930960
Pubmed	Opposing Gradients of MicroRNA Expression Temporally Pattern Layer Formation in the Developing Neocortex.	SOX5 RORB	1.43e-03	38	51	2	31080058
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	FLNC DNAH3 IDE ADAR NONO POLR3A	1.45e-03	847	51	6	35235311
Interaction	LLCFC1 interactions	CELSR3 CACNA2D2 SEL1L3 TMEM131 NLGN1	1.35e-05	121	51	5	int:LLCFC1
ToppCell	E18.5-samps-Mesenchymal-Pericyte-pericyte_B\|E18.5-samps / Age Group, Lineage, Cell class and subclass	MPP2 STARD9 NLGN2 EXTL2 RUSC2	8.26e-07	151	51	5	8ba15ab24fe2e71df0a2a7511ca451ad2376bd91
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1-41\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MPP2 B3GALT1 C1S NLGN1	3.22e-05	158	51	4	6d2709b387945c015faa223c20d22b52a4082140
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MPP2 SOX5 POLE NLGN1	3.46e-05	161	51	4	82ed45f144a07856fe92d37426c5f92e259a03a9
ToppCell	343B-Fibroblasts-Fibroblast-B_(Myofibroblast)\|343B / Donor, Lineage, Cell class and subclass (all cells)	GSDME ROBO1 ANGPTL5 GFRA1	5.01e-05	177	51	4	e55d21d4d61a069b9bbe0e7595fbfb7cfbacfd87
ToppCell	343B-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	GSDME ROBO1 ANGPTL5 GFRA1	5.01e-05	177	51	4	43ba6f12c2fb32698a420bf799d46ac1b558f146
ToppCell	facs-Large_Intestine-Proximal-18m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR3 GLDC NLGN2 ST18	5.35e-05	180	51	4	9db9899ca42455310e9b63df523fe6c4780abfb7
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	B3GALT1 SOX5 POLE C1S	5.46e-05	181	51	4	274c0b768925cd5804483303f8c5ebd17a534c41
ToppCell	E18.5-samps-Mesenchymal-Myofibroblast\|E18.5-samps / Age Group, Lineage, Cell class and subclass	B3GALT1 ROBO1 NLGN2 NLGN1	5.70e-05	183	51	4	de08f9ea02b7244d5a8788064631d10f06565337
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CACNG5\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TMEM266 RORB NLGN1 GFRA1	5.82e-05	184	51	4	658f2e522055e88c92bc482a845c40f8f5f1a8e3
ToppCell	COVID-19-Fibroblasts-Adventitial_FB\|COVID-19 / group, cell type (main and fine annotations)	SOX5 C1S NLGN1 GFRA1	5.95e-05	185	51	4	a5aebf2b9b05b550d021272731d68af9a6b1229d
ToppCell	wk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	MPP2 POLE SEL1L3 TMEM131	5.95e-05	185	51	4	636505a3d96f75d951ab42bcf8af6ae07abc732d
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ROBO1 C1S RORB ANGPTL5	6.07e-05	186	51	4	f07e0c0d9c80ac9d8d679950e7d0c812becb85a3
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	CEP350 TMEM131 IDE LRCH1	6.07e-05	186	51	4	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SOX5 STARD9 ROBO1 EPAS1	6.20e-05	187	51	4	15d6e158562d7d85af3ceaf955439b379c8fce81
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SOX5 STARD9 ROBO1 EPAS1	6.20e-05	187	51	4	f62074b631fd45ad299c69d71b09267b04d656ee
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MPP2 C1S ANGPTL5 GFRA1	6.33e-05	188	51	4	e18065bbc26d6f3774fd1f478fb41d8fb555fa26
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SOX5 ROBO1 C1S GFRA1	6.46e-05	189	51	4	71397e993a77d70b2eeede240bdfc7660b558987
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SOX5 ROBO1 C1S GFRA1	6.46e-05	189	51	4	4eea4759520c312bd17a681034d8074e47093d2b
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	C1S NLGN2 ANGPTL5 GFRA1	6.46e-05	189	51	4	d531399749409d614adca13d181830c6e3287508
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|368C / Donor, Lineage, Cell class and subclass (all cells)	HENMT1 STARD9 FHIP2B POLR3A	6.46e-05	189	51	4	610d7cc1fc923dbd67d3b71f94d529a658982f87
ToppCell	Control-Endothelial-VE_Venous\|Endothelial / Disease state, Lineage and Cell class	ROBO1 C1S NLGN1 EPAS1	6.59e-05	190	51	4	4e30155203b4a8c5e496fcbe9348b67b98ebc625
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	HENMT1 STARD9 FHIP2B POLR3A	6.73e-05	191	51	4	cadb7a9de16f4bb21606de0e25cddd2d748c7f0b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SOX5 ROBO1 C1S GFRA1	6.87e-05	192	51	4	5105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SOX5 ROBO1 C1S GFRA1	6.87e-05	192	51	4	d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	STARD9 ATXN1L FHIP2B POLR3A	6.87e-05	192	51	4	efbd52b3d2b6d3fb9ed6bc3f36aca9f4f1fcbc49
ToppCell	COVID-19-Fibroblasts-Other_FB\|COVID-19 / group, cell type (main and fine annotations)	SOX5 ROBO1 C1S GFRA1	7.01e-05	193	51	4	e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCell	LPS-antiTNF-Stromal_mesenchymal\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SOX5 ROBO1 C1S GFRA1	7.15e-05	194	51	4	6e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SOX5 ROBO1 C1S GFRA1	7.15e-05	194	51	4	90efdbd7f1c85fd7fd622b10340250b1d8fc1197
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SOX5 ROBO1 C1S GFRA1	7.15e-05	194	51	4	df82cce5ebeb73740b02cf816c6df82253cfd566
ToppCell	IPF-Endothelial-VE_Venous\|Endothelial / Disease state, Lineage and Cell class	ROBO1 C1S NLGN1 EPAS1	7.15e-05	194	51	4	e8a9005963704286bcc50785bda8d7d63ec001b1
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MPP2 C1S NLGN1 GFRA1	7.29e-05	195	51	4	ff0aa455e9844a6d7ae57ff59fb6cea825cf1fc2
ToppCell	Bronchial-NucSeq-Stromal-Schwann-Schwann_Myelinating\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	GLDC TMEM266 NLGN2 GFRA1	7.44e-05	196	51	4	efeb272bc9e37e60d15d056b7574991c5c7501bc
ToppCell	COPD-Stromal-Fibroblast\|World / Disease state, Lineage and Cell class	C1S NLGN1 ANGPTL5 GFRA1	7.73e-05	198	51	4	2f13c0b3372af53d1bd85f9546f315c878580a71
ToppCell	distal-mesenchymal-Myofibroblast-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MPP2 ROBO1 C1S GFRA1	7.73e-05	198	51	4	beef5075ba6dcd4d0a447bc4e57efcaf2e93c546
ToppCell	Sepsis-URO-Lymphocyte-B-B_intermediate\|URO / Disease, condition lineage and cell class	SOX5 GLDC SEL1L3 ROBO1	7.73e-05	198	51	4	aea2defa941adc8eeee601885cd13817ba108e57
ToppCell	LPS_only-Epithelial_airway-airway_epithelial\|LPS_only / Treatment groups by lineage, cell group, cell type	DNAH3 CDH26 SEL1L3 ERVFRD-1	7.73e-05	198	51	4	e035380578c01b0243bfef29ca9b50cc17cce771
ToppCell	LPS_only-Epithelial_airway\|LPS_only / Treatment groups by lineage, cell group, cell type	DNAH3 CDH26 SEL1L3 ERVFRD-1	7.73e-05	198	51	4	ba090210392e001a3f7bdf09371b3f0e0c8c7ef3
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	C1S NLGN1 ANGPTL5 GFRA1	7.89e-05	199	51	4	f835e7ffe976843b0edbf695762d463da85793f3
ToppCell	Bronchial-10x5prime-Stromal-Peri/Epineurial_\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	C1S NLGN1 ARHGEF37 ANGPTL5	7.89e-05	199	51	4	45c3b853900d8c3d5965117d904e3714100138bc
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-AF2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	C1S NLGN1 ANGPTL5 GFRA1	7.89e-05	199	51	4	993fa050a095017135a6e723c77cd38b9d782e58
ToppCell	distal-2-mesenchymal-Myofibroblast\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MPP2 ROBO1 C1S GFRA1	7.89e-05	199	51	4	b8f3cf5bcfde1066bdb49b14fdc842fe9692a6b7
ToppCell	distal-mesenchymal-Adventitial_Fibroblast-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	C1S NLGN1 ANGPTL5 GFRA1	7.89e-05	199	51	4	6e8a44e46b46e87b81dbfc56fcbbcde166fd00fe
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SOX5 FLNC EPAS1 SSUH2	8.04e-05	200	51	4	93e13937ec74418a697c37d56f57509fb2154780
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-NP-L5_NP_ALM_Trhr_Nefl\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DNAH3 C1S TMC3	1.45e-04	89	51	3	eda156a61e7d14087cfdae5e733d6862834fb0e5
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P5-P5_1-Sox4-POLYDENDROCYTE_(Rostral-�migratory_stream-�(RMS)_(Stmn2))\|Striatum / BrainAtlas - Mouse McCarroll V32	POLE ARHGEF37 TMC3	1.50e-04	90	51	3	7efc3437489c8587b9805547da1095f50d20cf6d
Disease	sulfhydryl oxidase 1 measurement	CEP350 C1S	8.10e-06	3	49	2	EFO_0802099
Disease	lung cancer (implicated_via_orthology)	POLE ROBO1	9.65e-05	9	49	2	DOID:1324 (implicated_via_orthology)
Disease	pain	SOX5 NLGN1 LRCH1 FHIP2B	3.17e-04	196	49	4	EFO_0003843
Disease	migraine without aura, susceptibility to, 4	MPP2 GFRA1	3.19e-04	16	49	2	MONDO_0011847
Disease	asthma exacerbation measurement	EXTL2 CDH12 SSUH2	5.03e-04	93	49	3	EFO_0007614
Disease	visual perception measurement	MPP2 B3GALT1 ST18 SSUH2	5.15e-04	223	49	4	EFO_0009700
Disease	non-alcoholic fatty liver disease, type 2 diabetes mellitus	MPP2 ROBO1 ST18	8.20e-04	110	49	3	EFO_0003095, MONDO_0005148
Disease	oppositional defiant disorder measurement	SOX5 ST18	1.64e-03	36	49	2	EFO_0007679

Protein segments in the cluster

Peptide	Gene	Start	Entry
PVAPHSPFLLDKFQQ	EPAS1	576	Q99814
RNVKFPPEHPVENDV	CFAP97	71	Q9P2B7
HPNLKPQTTNFREPV	CACNA2D2	561	Q9NY47
LRSFQETFEKVQPPP	ARHGEF37	471	A1IGU5
PQAHVDIYEKQPVPF	FDXR	61	P22570
FHPFAELPEPQQTAL	GSDME	296	O60443
RPINPHSFEFLINEP	B3GALT1	56	Q9Y5Z6
QPPRNITKEPKVFFH	C19orf18	46	Q8NEA5
FRKQLDPFPHRPVQS	ANGPTL5	131	Q86XS5
VPHQRPSVFQQPVIF	AGO4	571	Q9HCK5
EPPQRISFKEPHIFS	IQCM	101	A0A1B0GVH7
QFHKEREQPPRFAQP	NONO	246	Q15233
QQSKVSIEVPPEHPF	ATXN1L	531	P0C7T5
PHPIPVIFKQQTANR	EXTL2	116	Q9UBQ6
AKPFVPNVHAAEFVP	GSPT2	56	Q8IYD1
IAFVKFPPHDPRQNV	FHIP2B	721	Q86V87
PKFPTRVHVQPAVDT	FLNC	1236	Q14315
PVKGEFHQEFQPEPS	LRCH1	371	Q9Y2L9
PSYQEPHLPRQVFVK	MPP2	241	Q14168
IQHQLESEKFPPLFP	POLE	686	Q07864
DPNQPVPQDTKFIHT	NLGN1	591	Q8N2Q7
FEEVPRETAIQFKPP	HENMT1	16	Q5T8I9
PKDSRENFFPVTVVP	CABIN1	1931	Q9Y6J0
QSGPPHEPRFKFQVV	ADAR	526	P55265
ERFINHPEFQPAVIK	DNAH3	2861	Q8TD57
PFISDVFQQVEHIPK	GFRA1	136	P56159
PHSPIVEEFQVPYNK	C1S	91	P09871
IFAPPQKISHIPENF	CEP350	2556	Q5VT06
NDPPAFHPQSFIVNK	CDH26	391	Q8IXH8
DVNDNPPRFPKSIFH	CDH12	261	P55289
PEFPEHPFQEEHLKQ	IDE	286	P14735
VPNLPENFPVSHKDF	CELSR3	1676	Q9NYQ7
FHAAVQRKLPDVPNP	FLAD1	416	Q8NFF5
DPNQPVPQDTKFIHT	NLGN2	546	Q8NFZ4
TLPIQPFVFQHHFPK	RUSC2	691	Q8N2Y8
VKPQHRVPRPDTGFQ	SPATA48	136	A4D263
QTIPPFERPFKDHQV	SEL1L3	206	Q68CR1
FRKDFQQINPPHRGP	TMC3	856	Q7Z5M5
EPSAVLKRHPQPEFF	PRAM1	361	Q96QH2
NPPKRPLIFDTNEFH	POLR3A	1371	O14802
EFEPHIVPSTKNPHQ	SURF2	66	Q15527
HPQVQKITPNPFRSR	STARD9	2141	Q9P2P6
PPMFQEDTRKFQVPH	SSUH2	156	Q9Y2M2
ESKHFPNPVKFPNRL	ST18	531	O60284
FRHQPRFPKPPNITF	ERVFRD-1	166	P60508
PPEKVQRLYVDFPQH	STAT6	11	P42226
RPTPQNDAITVHFKP	TMEM131	361	Q92545
FKQSHPEIVNTLFPP	RORB	441	Q92753
TVQEPPHFVVKPRDQ	ROBO1	346	Q9Y6N7
VSFPNKPHSEEFQPV	SOX5	56	P35711
FQIRPVIHFQPTVPM	TMEM266	496	Q2M3C6
REVAAFPLPFVKPEN	GLDC	966	P23378