Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	endopeptidase activity	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 TMPRSS2 KLK3 KLK2 ADAMTSL2	6.72e-08	430	27	8	GO:0004175
GeneOntologyMolecularFunction	metalloendopeptidase activity	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	5.23e-07	120	27	5	GO:0004222
GeneOntologyMolecularFunction	peptidase activity	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 TMPRSS2 KLK3 KLK2 ADAMTSL2	1.62e-06	654	27	8	GO:0008233
GeneOntologyMolecularFunction	metallopeptidase activity	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	6.47e-06	200	27	5	GO:0008237
GeneOntologyMolecularFunction	signaling receptor regulator activity	ANGPT2 KLK3 PATE4 KLK2 WNT16	1.26e-03	616	27	5	GO:0030545
GeneOntologyMolecularFunction	serine-type endopeptidase activity	TMPRSS2 KLK3 KLK2	2.10e-03	190	27	3	GO:0004252
GeneOntologyMolecularFunction	serine-type peptidase activity	TMPRSS2 KLK3 KLK2	2.67e-03	207	27	3	GO:0008236
GeneOntologyMolecularFunction	serine hydrolase activity	TMPRSS2 KLK3 KLK2	2.86e-03	212	27	3	GO:0017171
GeneOntologyMolecularFunction	extracellular matrix binding	ADAMTS15 ADAMTSL2	4.36e-03	73	27	2	GO:0050840
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	KLK3 KLK2	5.34e-03	81	27	2	GO:0016811
GeneOntologyMolecularFunction	zinc ion binding	ADAMTS15 ADAMTS20 UHRF1 ZFAND3 PARP1	6.23e-03	891	27	5	GO:0008270
GeneOntologyBiologicalProcess	tissue kallikrein-kinin cascade	KLK3 KLK2	4.58e-06	3	26	2	GO:0002255
GeneOntologyBiologicalProcess	bradykinin biosynthetic process	KLK3 KLK2	9.15e-06	4	26	2	GO:0002936
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by renin-angiotensin	KCNN4 KLK3 KLK2	1.34e-05	37	26	3	GO:0003081
GeneOntologyBiologicalProcess	kinin cascade	KLK3 KLK2	2.28e-05	6	26	2	GO:0002254
GeneOntologyBiologicalProcess	left ventricular cardiac muscle tissue morphogenesis	KLK3 KLK2	3.20e-05	7	26	2	GO:0003220
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by hormone	KCNN4 KLK3 KLK2	3.56e-05	51	26	3	GO:0001990
GeneOntologyBiologicalProcess	brain renin-angiotensin system	KLK3 KLK2	5.47e-05	9	26	2	GO:0002035
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure mediated by a chemical signal	KCNN4 KLK3 KLK2	6.10e-05	61	26	3	GO:0003044
GeneOntologyBiologicalProcess	extracellular matrix organization	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	9.52e-05	377	26	5	GO:0030198
GeneOntologyBiologicalProcess	extracellular structure organization	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	9.64e-05	378	26	5	GO:0043062
GeneOntologyBiologicalProcess	external encapsulating structure organization	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	9.76e-05	379	26	5	GO:0045229
GeneOntologyBiologicalProcess	regulation of blood volume by renin-angiotensin	KLK3 KLK2	1.38e-04	14	26	2	GO:0002016
GeneOntologyBiologicalProcess	negative regulation of cellular response to vascular endothelial growth factor stimulus	ADAMTS12 ADGRA2	2.58e-04	19	26	2	GO:1902548
GeneOntologyBiologicalProcess	protein activation cascade	KLK3 KLK2	4.15e-04	24	26	2	GO:0072376
GeneOntologyBiologicalProcess	nervous system process involved in regulation of systemic arterial blood pressure	KLK3 KLK2	4.15e-04	24	26	2	GO:0001976
GeneOntologyBiologicalProcess	protein processing	TMPRSS2 PARP1 KLK3 KLK2	4.20e-04	285	26	4	GO:0016485
GeneOntologyBiologicalProcess	cardiac left ventricle morphogenesis	KLK3 KLK2	4.50e-04	25	26	2	GO:0003214
GeneOntologyBiologicalProcess	endocrine process	KCNN4 KLK3 KLK2	4.87e-04	123	26	3	GO:0050886
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure	KCNN4 KLK3 KLK2	4.98e-04	124	26	3	GO:0003073
GeneOntologyBiologicalProcess	muscle system process	PROK2 KCNN4 PARP1 KLK3 KLK2	5.34e-04	547	26	5	GO:0003012
GeneOntologyBiologicalProcess	protein autoprocessing	TMPRSS2 PARP1	6.50e-04	30	26	2	GO:0016540
GeneOntologyBiologicalProcess	heart morphogenesis	ADAMTS19 KLK3 KLK2 WNT16	6.57e-04	321	26	4	GO:0003007
GeneOntologyBiologicalProcess	regulation of cellular response to vascular endothelial growth factor stimulus	ADAMTS12 ADGRA2	7.40e-04	32	26	2	GO:1902547
GeneOntologyBiologicalProcess	peptide biosynthetic process	KLK3 KLK2	8.36e-04	34	26	2	GO:0043043
GeneOntologyBiologicalProcess	cardiac chamber morphogenesis	ADAMTS19 KLK3 KLK2	1.06e-03	161	26	3	GO:0003206
GeneOntologyBiologicalProcess	cardiac ventricle development	ADAMTS19 KLK3 KLK2	1.06e-03	161	26	3	GO:0003231
GeneOntologyBiologicalProcess	inflammatory response	ADAMTS12 PROK2 KCNN4 LY75 KLK3 KLK2	1.59e-03	1043	26	6	GO:0006954
GeneOntologyBiologicalProcess	circulatory system development	PROK2 ADAMTS19 ANGPT2 KLK3 ADGRA2 KLK2 WNT16	1.62e-03	1442	26	7	GO:0072359
GeneOntologyCellularComponent	extracellular matrix	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ANGPT2 ADAMTSL2	1.26e-04	656	26	6	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ANGPT2 ADAMTSL2	1.28e-04	658	26	6	GO:0030312
GeneOntologyCellularComponent	acrosomal vesicle	KLK3 PATE4 KLK2	2.07e-03	206	26	3	GO:0001669
MousePheno	decreased vasodilation	KCNN4 KLK3 KLK2	2.35e-05	33	24	3	MP:0005591
MousePheno	abnormal uterine artery morphology	KLK3 KLK2	2.82e-05	5	24	2	MP:0003995
MousePheno	decreased heart left ventricle weight	KLK3 KLK2	1.01e-04	9	24	2	MP:0003916
MousePheno	decreased heart left ventricle posterior wall thickness	KLK3 KLK2	2.93e-04	15	24	2	MP:0014316
MousePheno	abnormal heart left ventricle morphology	TRAPPC10 KCNN4 ADAMTS19 KLK3 KLK2	3.50e-04	369	24	5	MP:0003921
MousePheno	abnormal vasodilation	KCNN4 KLK3 KLK2	3.60e-04	82	24	3	MP:0001613
MousePheno	abnormal blood vessel physiology	KCNN4 ANGPT2 KLK3 ADGRA2 KLK2	4.73e-04	394	24	5	MP:0000249
MousePheno	abnormal vasculature physiology	KCNN4 ANGPT2 KLK3 ADGRA2 KLK2	5.31e-04	404	24	5	MP:0031170
MousePheno	abnormal heart left ventricle wall morphology	TRAPPC10 KLK3 KLK2	6.26e-04	99	24	3	MP:0031533
Domain	ADAM_spacer1	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	1.15e-10	23	26	5	IPR010294
Domain	ADAM_spacer1	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	1.15e-10	23	26	5	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	1.45e-10	24	26	5	IPR013273
Domain	TSP_1	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	2.31e-08	63	26	5	PF00090
Domain	TSP1	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	2.71e-08	65	26	5	SM00209
Domain	TSP1_rpt	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	2.71e-08	65	26	5	IPR000884
Domain	TSP1	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	2.71e-08	65	26	5	PS50092
Domain	Peptidase_M12B_N	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19	2.35e-07	39	26	4	IPR002870
Domain	Pep_M12B_propep	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19	2.35e-07	39	26	4	PF01562
Domain	DISINTEGRIN_1	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19	2.61e-07	40	26	4	PS00427
Domain	ADAM_MEPRO	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19	2.61e-07	40	26	4	PS50215
Domain	DISINTEGRIN_2	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19	2.61e-07	40	26	4	PS50214
Domain	Reprolysin	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19	2.61e-07	40	26	4	PF01421
Domain	Peptidase_M12B	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19	2.61e-07	40	26	4	IPR001590
Domain	Disintegrin_dom	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19	2.88e-07	41	26	4	IPR001762
Domain	PLAC	ADAMTS12 ADAMTS19 ADAMTSL2	2.29e-06	19	26	3	IPR010909
Domain	PLAC	ADAMTS12 ADAMTS19 ADAMTSL2	2.29e-06	19	26	3	PS50900
Domain	MetalloPept_cat_dom	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19	4.56e-06	81	26	4	IPR024079
Domain	-	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19	4.56e-06	81	26	4	3.40.390.10
Domain	ZINC_PROTEASE	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19	9.75e-06	98	26	4	PS00142
Domain	CYSTEINE_SWITCH	ADAMTS12 ADAMTS15 ADAMTS19	2.46e-05	41	26	3	PS00546
Domain	Pept_M10_metallopeptidase	ADAMTS12 ADAMTS15 ADAMTS19	2.85e-05	43	26	3	IPR001818
Domain	PLAC	ADAMTS19 ADAMTSL2	1.68e-04	14	26	2	PF08686
Domain	TRYPSIN_SER	TMPRSS2 KLK3 KLK2	2.60e-04	90	26	3	IPR033116
Domain	TRYPSIN_HIS	TMPRSS2 KLK3 KLK2	3.86e-04	103	26	3	IPR018114
Domain	TRYPSIN_SER	TMPRSS2 KLK3 KLK2	4.20e-04	106	26	3	PS00135
Domain	TRYPSIN_HIS	TMPRSS2 KLK3 KLK2	4.32e-04	107	26	3	PS00134
Domain	Peptidase_S1A	TMPRSS2 KLK3 KLK2	5.07e-04	113	26	3	IPR001314
Domain	TRYPSIN_DOM	TMPRSS2 KLK3 KLK2	5.33e-04	115	26	3	PS50240
Domain	Tryp_SPc	TMPRSS2 KLK3 KLK2	5.61e-04	117	26	3	SM00020
Domain	Trypsin	TMPRSS2 KLK3 KLK2	6.18e-04	121	26	3	PF00089
Domain	Trypsin_dom	TMPRSS2 KLK3 KLK2	6.18e-04	121	26	3	IPR001254
Domain	ADAM_Cys-rich	ADAMTS15 ADAMTS19	6.40e-04	27	26	2	IPR006586
Domain	ACR	ADAMTS15 ADAMTS19	6.40e-04	27	26	2	SM00608
Domain	Peptidase_S1_PA	TMPRSS2 KLK3 KLK2	6.49e-04	123	26	3	IPR009003
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	3.16e-09	39	22	5	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	3.16e-09	39	22	5	MM15165
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	5.56e-08	68	22	5	M27303
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	5.98e-07	109	22	5	MM15164
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	6.54e-07	111	22	5	M27416
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	2.29e-06	143	22	5	M27275
Pathway	REACTOME_DISEASES_OF_METABOLISM	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	3.47e-05	250	22	5	M27554
Pathway	PID_AR_TF_PATHWAY	TMPRSS2 KLK3 KLK2	7.35e-05	53	22	3	M151
Pathway	PID_AR_PATHWAY	TMPRSS2 KLK3 KLK2	1.12e-04	61	22	3	M58
Pathway	BIOCARTA_CDK5_PATHWAY	KLK3 KLK2	2.09e-04	14	22	2	MM1457
Pathway	BIOCARTA_TRKA_PATHWAY	KLK3 KLK2	2.41e-04	15	22	2	MM1523
Pathway	BIOCARTA_NGF_PATHWAY	KLK3 KLK2	5.27e-04	22	22	2	MM1440
Pathway	BIOCARTA_ERK_PATHWAY	KLK3 KLK2	8.57e-04	28	22	2	MM1391
Pathway	REACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES	KLK3 KLK2	1.58e-03	38	22	2	MM14611
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	3.17e-09	75	27	5	20637190
Pubmed	Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice.	TMPRSS2 KLK3 KLK2	5.50e-07	21	27	3	19592578
Pubmed	Genetic variation in KLK2 and KLK3 is associated with concentrations of hK2 and PSA in serum and seminal plasma in young men.	KLK3 KLK2	5.80e-07	2	27	2	24270797
Pubmed	Detection of prostate specific transcripts in the peripheral blood during brachytherapy predicts postoperative PSA kinetics.	KLK3 KLK2	5.80e-07	2	27	2	19434652
Pubmed	Early prediction of prostate cancer biochemical recurrence and identification of disease persistence using PSA isoforms and human kallikrein-2.	KLK3 KLK2	5.80e-07	2	27	2	34486998
Pubmed	The predictive value of prostate cancer biomarkers depends on age and time to diagnosis: towards a biologically-based screening strategy.	KLK3 KLK2	5.80e-07	2	27	2	17657743
Pubmed	Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin.	KLK3 KLK2	5.80e-07	2	27	2	17593395
Pubmed	KLK3 and TMPRSS2 for molecular lymph-node staging in prostate cancer patients undergoing radical prostatectomy.	TMPRSS2 KLK3	5.80e-07	2	27	2	32978525
Pubmed	Evaluation of molecular forms of prostate-specific antigen and human kallikrein 2 in predicting biochemical failure after radical prostatectomy.	KLK3 KLK2	5.80e-07	2	27	2	19003994
Pubmed	Proteomic analysis of patient tissue reveals PSA protein in the stroma of benign prostatic hyperplasia.	KLK3 KLK2	5.80e-07	2	27	2	24711254
Pubmed	Risk assessment for biochemical recurrence prior to radical prostatectomy: significant enhancement contributed by human glandular kallikrein 2 (hK2) and free prostate specific antigen (PSA) in men with moderate PSA-elevation in serum.	KLK3 KLK2	5.80e-07	2	27	2	16152616
Pubmed	Ethnic variation in kallikrein expression in nipple aspirate fluid.	KLK3 KLK2	5.80e-07	2	27	2	12209605
Pubmed	Predictive value of four kallikrein markers for pathologically insignificant compared with aggressive prostate cancer in radical prostatectomy specimens: results from the European Randomized Study of Screening for Prostate Cancer section Rotterdam.	KLK3 KLK2	5.80e-07	2	27	2	23683475
Pubmed	Unusual alternative splicing within the human kallikrein genes KLK2 and KLK3 gives rise to novel prostate-specific proteins.	KLK3 KLK2	5.80e-07	2	27	2	11834722
Pubmed	A complete cDNA sequence for the major epidermal growth factor binding protein in the male mouse submandibular gland.	KLK3 KLK2	1.74e-06	3	27	2	3322386
Pubmed	Critical role of tissue kallikrein in vessel formation and maturation: implications for therapeutic revascularization.	KLK3 KLK2	1.74e-06	3	27	2	19164804
Pubmed	Tissue kallikrein deficiency and renovascular hypertension in the mouse.	KLK3 KLK2	1.74e-06	3	27	2	19244588
Pubmed	Differences in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreins.	KLK3 KLK2	1.74e-06	3	27	2	15040788
Pubmed	Inducible expression of kallikrein in renal tubular cells protects mice against spontaneous lupus nephritis.	KLK3 KLK2	1.74e-06	3	27	2	23280471
Pubmed	Mouse glandular kallikrein genes. Nucleotide sequence of cloned cDNA coding for a member of the kallikrein arginyl esteropeptidase group of serine proteases.	KLK3 KLK2	1.74e-06	3	27	2	6174512
Pubmed	Regional and global protective effects of tissue kallikrein gene delivery to the peri-infarct myocardium.	KLK3 KLK2	1.74e-06	3	27	2	17465807
Pubmed	Protease-activated receptor dependent and independent signaling by kallikreins 1 and 6 in CNS neuron and astroglial cell lines.	KLK3 KLK2	1.74e-06	3	27	2	18778305
Pubmed	beta-NGF-endopeptidase: structure and activity of a kallikrein encoded by the gene mGK-22.	KLK3 KLK2	1.74e-06	3	27	2	2012805
Pubmed	Mouse kallikrein arginyl-esteropeptidase genes: analysis of cloned cDNAs suggests rapid functional divergence from a common ancestral sequence.	KLK3 KLK2	1.74e-06	3	27	2	6926406
Pubmed	Genetic deficiency in tissue kallikrein activity in mouse and man: effect on arteries, heart and kidney.	KLK3 KLK2	1.74e-06	3	27	2	18627303
Pubmed	Tissue kallikrein is required for the cardioprotective effect of cyclosporin A in myocardial ischemia in the mouse.	KLK3 KLK2	1.74e-06	3	27	2	25623731
Pubmed	7S Nerve growth factor alpha and gamma subunits are closely related proteins.	KLK3 KLK2	1.74e-06	3	27	2	6712944
Pubmed	Kallikrein protects against microalbuminuria in experimental type I diabetes.	KLK3 KLK2	1.74e-06	3	27	2	19516248
Pubmed	Single-chain tissue-type plasminogen activator is a substrate of mouse glandular kallikrein 24.	KLK3 KLK2	1.74e-06	3	27	2	16286722
Pubmed	mGK-6-derived true tissue kallikrein is synthesized, processed, and targeted through a regulated secretory pathway in mouse pituitary AtT-20 cells.	KLK3 KLK2	1.74e-06	3	27	2	1639762
Pubmed	Serendipitous Discovery of T Cell-Produced KLK1b22 as a Regulator of Systemic Metabolism.	KLK3 KLK2	1.74e-06	3	27	2	37358498
Pubmed	Tissue kallikrein is essential for invasive capacity of circulating proangiogenic cells.	KLK3 KLK2	1.74e-06	3	27	2	21164105
Pubmed	Autoimmunity against a tissue kallikrein in IQI/Jic Mice: a model for Sjogren's syndrome.	KLK3 KLK2	1.74e-06	3	27	2	15545270
Pubmed	Estrogen-dependent expression of the tissue kallikrein gene (Klk1) in the mouse uterus and its implications for endometrial tissue growth.	KLK3 KLK2	1.74e-06	3	27	2	17219431
Pubmed	Sequence and expression of mouse gamma-renin.	KLK3 KLK2	1.74e-06	3	27	2	3288617
Pubmed	Role of TMPRSS2-ERG gene fusion in negative regulation of PSMA expression.	TMPRSS2 KLK3	1.74e-06	3	27	2	21731703
Pubmed	Analysis of androgen and anti-androgen regulation of KLK-related peptidase 2, 3, and 4 alternative transcripts in prostate cancer.	KLK3 KLK2	1.74e-06	3	27	2	25153393
Pubmed	Tissue kallikrein stimulates Ca(2+) reabsorption via PKC-dependent plasma membrane accumulation of TRPV5.	KLK3 KLK2	1.74e-06	3	27	2	17006539
Pubmed	Characterization of mouse glandular kallikrein 24 expressed in testicular Leydig cells.	KLK3 KLK2	1.74e-06	3	27	2	15985384
Pubmed	Characterization of androgen receptor and nuclear receptor co-regulator expression in human breast cancer cell lines exhibiting differential regulation of kallikreins 2 and 3.	KLK3 KLK2	1.74e-06	3	27	2	12124798
Pubmed	Porcine kallikrein gene family: genomic structure, mapping, and differential expression analysis.	KLK3 KLK2	1.74e-06	3	27	2	17210241
Pubmed	Deletion of kallikrein 1b5 (Klk1b5) has no impact on fertility in mice.	KLK3 KLK2	1.74e-06	3	27	2	30957940
Pubmed	A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33.	KLK3 KLK2	1.74e-06	3	27	2	19823874
Pubmed	Sequence of an epidermal growth factor-binding protein.	KLK3 KLK2	1.74e-06	3	27	2	6330081
Pubmed	Antihypertensive role of tissue kallikrein in hyperaldosteronism in the mouse.	KLK3 KLK2	1.74e-06	3	27	2	22669897
Pubmed	Cloning and characterization of mouse klk27, a novel tissue kallikrein expressed in testicular Leydig cells and exhibiting chymotrypsin-like specificity.	KLK3 KLK2	1.74e-06	3	27	2	11082197
Pubmed	Genes for the alpha and gamma subunits of mouse nerve growth factor are contiguous.	KLK3 KLK2	1.74e-06	3	27	2	3848399
Pubmed	Detection of a kallikrein in the mouse lactating mammary gland: a possible processing enzyme for the epidermal growth factor precursor.	KLK3 KLK2	1.74e-06	3	27	2	7525260
Pubmed	Mouse glandular kallikrein genes. Identification, structure, and expression of the renal kallikrein gene.	KLK3 KLK2	1.74e-06	3	27	2	3007510
Pubmed	Identification of mK1, a true tissue (glandular) kallikrein of mouse submandibular gland: tissue distribution and a comparison of kinin-releasing activity with other submandibular kallikreins.	KLK3 KLK2	1.74e-06	3	27	2	8188620
Pubmed	Mouse testicular Leydig cells express Klk21, a tissue kallikrein that cleaves fibronectin and IGF-binding protein-3.	KLK3 KLK2	1.74e-06	3	27	2	11606460
Pubmed	Role of tissue kallikrein in response to flow in mouse resistance arteries.	KLK3 KLK2	1.74e-06	3	27	2	15126916
Pubmed	Blocking of plasma kallikrein ameliorates stroke by reducing thromboinflammation.	KLK3 KLK2	1.74e-06	3	27	2	25628066
Pubmed	Temporal and tissue-specific expression of kallikrein (Klk) genes and identification of a novel Klk messenger ribonucleic acid transcript during early development in the mouse.	KLK3 KLK2	1.74e-06	3	27	2	10456837
Pubmed	The molecular biology of the kallikrein-kinin system: I. General description, nomenclature and the mouse gene family.	KLK3 KLK2	1.74e-06	3	27	2	8228186
Pubmed	The sequence of a cDNA clone coding for a novel kallikrein from mouse submaxillary gland.	KLK3 KLK2	1.74e-06	3	27	2	3636812
Pubmed	Reduction in nerve growth factor availability leads to a conditioning lesion-like effect in sympathetic neurons.	KLK3 KLK2	1.74e-06	3	27	2	16967509
Pubmed	Growth factor-binding proteases in the murine submaxillary gland: isolation of a cDNA clone.	KLK3 KLK2	1.74e-06	3	27	2	11892812
Pubmed	Targeting kallikrein 6 proteolysis attenuates CNS inflammatory disease.	KLK3 KLK2	1.74e-06	3	27	2	15033932
Pubmed	Is there an inter-relationship between prostate specific antigen, kallikrein-2 and androgen receptor gene polymorphisms with risk of prostate cancer in north Indian population?	KLK3 KLK2	1.74e-06	3	27	2	17257635
Pubmed	Cardiovascular abnormalities with normal blood pressure in tissue kallikrein-deficient mice.	KLK3 KLK2	1.74e-06	3	27	2	11226291
Pubmed	Sequence of the mouse glandular kallikrein gene, mGK-5.	KLK3 KLK2	1.74e-06	3	27	2	3502721
Pubmed	Cellular basis for the differential response of mouse kallikrein genes to hormonal induction.	KLK3 KLK2	1.74e-06	3	27	2	3649290
Pubmed	Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis.	KLK3 KLK2	1.74e-06	3	27	2	22335454
Pubmed	Kallikrein-related peptidases.	KLK3 KLK2	1.74e-06	3	27	2	18344018
Pubmed	The amino acid sequence of the gamma-subunit of mouse submaxillary gland 7 S nerve growth factor.	KLK3 KLK2	1.74e-06	3	27	2	7263706
Pubmed	Positive selection shaped the convergent evolution of independently expanded kallikrein subfamilies expressed in mouse and rat saliva proteomes.	KLK3 KLK2	1.74e-06	3	27	2	21695125
Pubmed	Uterine artery structural and functional changes during pregnancy in tissue kallikrein-deficient mice.	KLK3 KLK2	1.74e-06	3	27	2	12933530
Pubmed	Isolation of a cDNA clone coding for the gamma-subunit of mouse nerve growth factor using a high-stringency selection procedure.	KLK3 KLK2	1.74e-06	3	27	2	6548955
Pubmed	The lupus-susceptibility gene kallikrein downmodulates antibody-mediated glomerulonephritis.	KLK3 KLK2	1.74e-06	3	27	2	19262577
Pubmed	Interference of kallikrein 1b26 (klk1b26) translation by microRNA specifically expressed in female mouse submandibular glands: an additional mechanism for sexual dimorphism of klk1b26 protein in the glands.	KLK3 KLK2	1.74e-06	3	27	2	22085651
Pubmed	Renin and kallikrein in connecting tubule of mouse.	KLK3 KLK2	1.74e-06	3	27	2	14633138
Pubmed	Sites of glandular kallikrein gene expression in fetal mice.	KLK3 KLK2	1.74e-06	3	27	2	1334010
Pubmed	A cytocidal tissue kallikrein isolated from mouse submandibular glands.	KLK3 KLK2	1.74e-06	3	27	2	2583286
Pubmed	Methylated-UHRF1 and PARP1 interaction is critical for homologous recombination.	UHRF1 PARP1	1.74e-06	3	27	2	31964471
Pubmed	Neuroprotective effect of kinin B1 receptor activation in acute cerebral ischemia in diabetic mice.	KLK3 KLK2	1.74e-06	3	27	2	28842604
Pubmed	Sequence of mGK-11, a mouse glandular kallikrein gene.	KLK3 KLK2	1.74e-06	3	27	2	3205728
Pubmed	Prognostic Significance of TMPRSS2-ERG Fusion Gene in Prostate Cancer.	TMPRSS2 KLK3	1.74e-06	3	27	2	27630329
Pubmed	Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides.	KLK3 KLK2	1.74e-06	3	27	2	6602295
Pubmed	Mouse 7S nerve growth factor: complete sequence of a cDNA coding for the alpha-subunit precursor and its relationship to serine proteases.	KLK3 KLK2	1.74e-06	3	27	2	6395888
Pubmed	MiR-382 targeting of kallikrein 5 contributes to renal inner medullary interstitial fibrosis.	KLK3 KLK2	3.48e-06	4	27	2	22202692
Pubmed	The presence of two types of prorenin converting enzymes in the mouse submandibular gland.	KLK3 KLK2	3.48e-06	4	27	2	1959648
Pubmed	Mouse glandular kallikrein genes: identification and characterization of the genes encoding the epidermal growth factor binding proteins.	KLK3 KLK2	3.48e-06	4	27	2	3322387
Pubmed	Decreased flow-dependent dilation in carotid arteries of tissue kallikrein-knockout mice.	KLK3 KLK2	3.48e-06	4	27	2	11282893
Pubmed	Flow-dependent dilation mediated by endogenous kinins requires angiotensin AT2 receptors.	KLK3 KLK2	3.48e-06	4	27	2	15131008
Pubmed	Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus.	KLK3 KLK2	3.48e-06	4	27	2	7623137
Pubmed	Vasoactive intestinal peptide regulation of nerve growth factor in the embryonic mouse.	KLK3 KLK2	3.48e-06	4	27	2	12383868
Pubmed	HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability.	KLK3 KLK2	3.48e-06	4	27	2	15542435
Pubmed	Enhanced neurotrophin-induced axon growth in myelinated portions of the CNS in mice lacking the p75 neurotrophin receptor.	KLK3 KLK2	3.48e-06	4	27	2	10234043
Pubmed	Neural driven angiogenesis by overexpression of nerve growth factor.	KLK3 KLK2	3.48e-06	4	27	2	16315017
Pubmed	Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22).	KLK3 KLK2	3.48e-06	4	27	2	9507064
Pubmed	Absence of the p75 neurotrophin receptor alters the pattern of sympathosensory sprouting in the trigeminal ganglia of mice overexpressing nerve growth factor.	KLK3 KLK2	3.48e-06	4	27	2	9870956
Pubmed	Mouse submandibular gland prorenin-converting enzyme is a member of glandular kallikrein family.	KLK3 KLK2	3.48e-06	4	27	2	1918045
Pubmed	Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease.	KLK3 KLK2	3.48e-06	4	27	2	15584920
Pubmed	Characterization of Spink6 in mouse skin: the conserved inhibitor of kallikrein-related peptidases is reduced by barrier injury.	KLK3 KLK2	3.48e-06	4	27	2	24352040
Pubmed	Tissue kallikrein deficiency, insulin resistance, and diabetes in mouse and man.	KLK3 KLK2	3.48e-06	4	27	2	24599937
Pubmed	p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins.	KLK3 KLK2	3.48e-06	4	27	2	8398147
Pubmed	Use of a cDNA recombinant for the gamma-subunit of mouse nerve growth factor to localize members of this multigene family near the TAM-1 locus on chromosome 7.	KLK3 KLK2	3.48e-06	4	27	2	6200835
Pubmed	Tissue kallikrein activation of the epithelial Na channel.	KLK3 KLK2	3.48e-06	4	27	2	22622459
Pubmed	KLK3, PCA3, and TMPRSS2-ERG expression in the peripheral blood mononuclear cell fraction from castration-resistant prostate cancer patients and response to docetaxel treatment.	TMPRSS2 KLK3	3.48e-06	4	27	2	25043536
Cytoband	19q13.41	KLK3 KLK2	9.73e-04	78	27	2	19q13.41
Cytoband	21q22.3	TRAPPC10 TMPRSS2	2.59e-03	128	27	2	21q22.3
Cytoband	Ensembl 112 genes in cytogenetic band chr12q21	NAP1L1 TMTC2	3.13e-03	141	27	2	chr12q21
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	KCNN4 ZNF776 KLK3 KLK2	4.93e-03	1192	27	4	chr19q13
Cytoband	Ensembl 112 genes in cytogenetic band chr11q24	ADAMTS15 PATE4	5.64e-03	191	27	2	chr11q24
Cytoband	Ensembl 112 genes in cytogenetic band chr21q22	TRAPPC10 TMPRSS2	2.06e-02	377	27	2	chr21q22
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19	7.61e-09	19	23	4	50
GeneFamily	Kallikreins	KLK3 KLK2	1.84e-04	16	23	2	616
Coexpression	NABA_ECM_REGULATORS	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	4.06e-06	238	27	5	M3468
Coexpression	NABA_ECM_REGULATORS	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ADAMTSL2	4.40e-06	242	27	5	MM17062
Coexpression	MARKEY_RB1_CHRONIC_LOF_UP	KCNN4 UHRF1 ANGPT2 ACAT2	5.51e-06	114	27	4	M2895
Coexpression	MARKEY_RB1_CHRONIC_LOF_UP	KCNN4 UHRF1 ANGPT2 ACAT2	5.91e-06	116	27	4	MM1090
Coexpression	NABA_MATRISOME_ASSOCIATED	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ANGPT2 ADAMTSL2 WNT16	7.40e-06	738	27	7	MM17058
Coexpression	NABA_MATRISOME_ASSOCIATED	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ANGPT2 ADAMTSL2 WNT16	8.30e-06	751	27	7	M5885
Coexpression	NABA_MATRISOME	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ANGPT2 ADAMTSL2 WNT16	5.51e-05	1008	27	7	MM17056
Coexpression	NABA_MATRISOME	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19 ANGPT2 ADAMTSL2 WNT16	6.16e-05	1026	27	7	M5889
Coexpression	ZHANG_BREAST_CANCER_PROGENITORS_UP	TRAPPC10 ADAMTS20 UHRF1 PARP1 ACAT2	7.27e-05	434	27	5	M15150
Coexpression	ZHANG_BREAST_CANCER_PROGENITORS_UP	TRAPPC10 ADAMTS20 UHRF1 PARP1 ACAT2	8.44e-05	448	27	5	MM1044
Coexpression	NELSON_RESPONSE_TO_ANDROGEN_UP	TMPRSS2 KLK3 KLK2	8.48e-05	83	27	3	M13903
Coexpression	WUNDER_INFLAMMATORY_RESPONSE_AND_CHOLESTEROL_UP	LY75 KLK3 KLK2	8.79e-05	84	27	3	MM1049
Coexpression	HALLMARK_ANDROGEN_RESPONSE	TMPRSS2 KLK3 KLK2	1.52e-04	101	27	3	M5908
Coexpression	DER_IFN_BETA_RESPONSE_UP	NAP1L1 TRAPPC10 PARP1	1.61e-04	103	27	3	M13453
Coexpression	WANG_RESPONSE_TO_FORSKOLIN_UP	KLK3 KLK2	2.55e-04	23	27	2	M14942
Coexpression	CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_UP	NAP1L1 KCNN4 UHRF1	3.05e-04	128	27	3	M8795
Coexpression	HORIUCHI_WTAP_TARGETS_DN	NAP1L1 UHRF1 ANGPT2 ACAT2	3.07e-04	320	27	4	M10279
Coexpression	YEGNASUBRAMANIAN_PROSTATE_CANCER	TMPRSS2 KLK3 KLK2	3.57e-04	135	27	3	M4034
Coexpression	CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_UP	NAP1L1 KCNN4 UHRF1	3.65e-04	136	27	3	MM464
Coexpression	WANG_RESPONSE_TO_ANDROGEN_UP	KLK3 KLK2	4.08e-04	29	27	2	M16075
Coexpression	MAEKAWA_ATF2_TARGETS	KLK3 KLK2	4.08e-04	29	27	2	MM899
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 UHRF1 ADGRA2 ADAMTSL2	3.15e-06	169	27	4	a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS12 UHRF1 ANGPT2 WNT16	3.79e-06	177	27	4	4553ee8cd9c24db6511b09fe49ed11a89e7cde9e
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	NAP1L1 ADAMTS12 ARHGEF17 ADAMTSL2	5.12e-06	191	27	4	e7c605b56934d1383237c1f946dbccef25d91368
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-SMC_prolif-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ADAMTS12 ANGPT2 ARHGEF17 ADGRA2	5.44e-06	194	27	4	78dcb9d48259afabe73b41c5508a73a8d62339a4
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS12 ADAMTS15 ANGPT2 WNT16	5.55e-06	195	27	4	43d372373367b71243c6ea958aedccde4478618f
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ADAMTS12 ANGPT2 ARHGEF17 ADGRA2	5.55e-06	195	27	4	d760d1423f9a8a373fe7b250ea9b1d67a0c0059f
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ADAMTS12 ANGPT2 ARHGEF17 ADGRA2	5.67e-06	196	27	4	40e6900a0d56088a40d37ec312f53207ea952602
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_pericyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ADAMTS12 ANGPT2 ARHGEF17 ADGRA2	5.67e-06	196	27	4	cb61757646653f89faba503cb5d99e5dd5197b4c
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ADAMTS12 ANGPT2 ARHGEF17 ADGRA2	5.67e-06	196	27	4	0b247cf981981ae61aca5de82ef687e8d783c9ef
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_pericyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ADAMTS12 ANGPT2 ARHGEF17 ADGRA2	5.67e-06	196	27	4	44e2df1b61e3819eae7e482bef0a733afe852d67
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ADAMTS12 ANGPT2 ARHGEF17 ADGRA2	5.78e-06	197	27	4	af819b0561c8db582c5b466d804153d69d3297e0
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ADAMTS12 ANGPT2 ARHGEF17 ADGRA2	5.78e-06	197	27	4	983502a99e6d59bb36225b0246a9990604de1a01
ToppCell	Tracheal-10x5prime-Stromal-Pericyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS12 ANGPT2 ARHGEF17 ADGRA2	6.02e-06	199	27	4	cefc3b50f65e95da850e4720c7b44bf584073491
ToppCell	Tracheal-10x5prime-Stromal-Pericyte-Muscle_pericyte_systemic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS12 ANGPT2 ARHGEF17 ADGRA2	6.02e-06	199	27	4	aaa460c389cd6d38a13ba1a446f91a94f9573ad8
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Smooth_muscle-1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ANGPT2 ARHGEF17 ADGRA2 ADAMTSL2	6.14e-06	200	27	4	43b76e382b38b9856c07557a75e5b1ce0cee1d9e
ToppCell	Parenchyma_COVID-19-Stromal-TX-Smooth_muscle-1\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	ANGPT2 ARHGEF17 ADGRA2 ADAMTSL2	6.14e-06	200	27	4	78e9a40153d7ba5d9ea6393a37d26fc5c0220867
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Smooth_muscle-1\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	ANGPT2 ARHGEF17 ADGRA2 ADAMTSL2	6.14e-06	200	27	4	c46e06b4f22d3456e67bc62a9ac198e8041965ad
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Rectal_Adenocarcinoma-5\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ADAMTS20 KLK3 KLK2	5.83e-05	125	27	3	c82b4bddc98b2a2d2ee00c1392df86f9735c0623
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_Chrna6\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TMPRSS2 TMTC2 ADAMTSL2	5.83e-05	125	27	3	fac8a9bff83abb8976013ff7d2b4ce0b68fbb70a
ToppCell	Serous\|World / shred by cell class for turbinate	KCNN4 ADAMTS19 KLK3	1.00e-04	150	27	3	6a326662d58b0f17d6efa8cc28571f4cbbf57c2d
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 ANGPT2 ARHGEF17	1.13e-04	156	27	3	6365b69ede98bc866e996bc52736b00401aacf6f
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 ANGPT2 ARHGEF17	1.15e-04	157	27	3	bfec34182f052cf1c0d847ba53ea335d4d1190de
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 KLK3 ADAMTSL2	1.19e-04	159	27	3	cbb331eb689d8cea9e1146ba85e0a05d23301c47
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 KLK3 ADAMTSL2	1.19e-04	159	27	3	330ecbba97d47bc818a5e8d1d84b05d056bd831e
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Basal_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	ADAMTS12 ADAMTS15 KCNN4	1.28e-04	163	27	3	f21951e63188eb0c04675a8f81a0da495c26c007
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PARP1 KLK2 WNT16	1.35e-04	166	27	3	a8ba4d51e778634f8a7f47fa0d01a2019f774fb8
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_B-B_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PARP1 KLK2 WNT16	1.35e-04	166	27	3	4906c85f52c3751166e296102d524a13b1f438f5
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PARP1 KLK2 WNT16	1.35e-04	166	27	3	04e32bd32165cdf316f2a8709c3662d55cd70391
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_B\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PARP1 KLK2 WNT16	1.40e-04	168	27	3	0ecc6503ea249a4b13c42cfec2b024338f7e6080
ToppCell	RA-01._Fibroblast_I\|RA / Chamber and Cluster_Paper	ADAMTS15 TMTC2 ADAMTSL2	1.43e-04	169	27	3	6373562ab3b1765060212a6a53d6543e7e942e80
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-hematopoietic_progenitor-erythroid_progenitor_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	KLK3 PATE4 KLK2	1.45e-04	170	27	3	74bb46826141bd1e80b4ce16e6bbfc770bd427d3
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-hematopoietic_progenitor\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	KLK3 PATE4 KLK2	1.45e-04	170	27	3	6592ebe204b43b81c6b6da99e05da72c0983b3fa
ToppCell	Adult-Mesenchymal-pericyte_cell-D231\|Adult / Lineage, Cell type, age group and donor	ANGPT2 ARHGEF17 ADGRA2	1.50e-04	172	27	3	858cee96c1c06160863b4adcd7023c0d678bd50f
ToppCell	PND14-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NAP1L1 UHRF1 CCDC93	1.55e-04	174	27	3	09b091e24317c3f7bac043f04762a533e30793de
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-Pericytes\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	ADAMTS12 ANGPT2 ADGRA2	1.61e-04	176	27	3	2015539c58aa0bb118e111ffedd63dd9fe863bb1
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANGPT2 ARHGEF17 ADGRA2	1.61e-04	176	27	3	90f36f10c6ed440a0ca549f23219398853f1fbc3
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS15 ANGPT2 WNT16	1.61e-04	176	27	3	4843af68f013732c28a8b8edad30d5fa0f2b084b
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PROK2 TMTC2 LY75	1.63e-04	177	27	3	68f1139fc378f351e3b9e9f392aacb150025bf03
ToppCell	facs-Lung-nan-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS12 ANGPT2 ARHGEF17	1.69e-04	179	27	3	7078022e60faa86444f2a2c6eb9f767cc66b5cfa
ToppCell	metastatic_Brain-Endothelial_cells-Lymphatic_ECs\|metastatic_Brain / Location, Cell class and cell subclass	ADAMTS12 ANGPT2 ADGRA2	1.69e-04	179	27	3	56fe381ffbaba3a4f2f587a3e367b0d11fbd4a2a
ToppCell	facs-Lung-nan-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS12 ANGPT2 ARHGEF17	1.69e-04	179	27	3	d4a975d8ffa5e77fb5c0ec05bf9c8f843c77ce07
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-SMC_prolif\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ADAMTS12 ARHGEF17 ADGRA2	1.72e-04	180	27	3	64956a85c404a2ea7e4eaf6f95ebcc52c198b7cc
ToppCell	RA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	ADAMTS15 TMTC2 ADAMTSL2	1.74e-04	181	27	3	2b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCell	RA-07._Pericyte\|RA / Chamber and Cluster_Paper	ADAMTS12 ARHGEF17 ADGRA2	1.74e-04	181	27	3	8dfb42d096db6c2df9b41303a7199d134d4bff07
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NAP1L1 UHRF1 PARP1	1.80e-04	183	27	3	956ff95aef9c5521b6a3ba7ac6df0aad242c1c35
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 ANGPT2 ARHGEF17	1.80e-04	183	27	3	8a799807fbf24456a9811e0c64068187940a2f71
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-Proliferating_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNN4 UHRF1 ACAT2	1.80e-04	183	27	3	769a022fe8568ec49e66f792cc5777e713a7571c
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1-41\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTS15 ADAMTS19 WNT16	1.80e-04	183	27	3	07ca2786e62eca9feecf5e54a11864a960f7641a
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNN4 UHRF1 ACAT2	1.80e-04	183	27	3	aac0695fafa59cabd920ee18b1139d3e00d898e8
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 ANGPT2 ARHGEF17	1.83e-04	184	27	3	102b6f621a5b551e622f97b12d787c080b052a72
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 ANGPT2 ARHGEF17	1.83e-04	184	27	3	689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 ANGPT2 ARHGEF17	1.83e-04	184	27	3	327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTS15 ARHGEF17 ADAMTSL2	1.86e-04	185	27	3	9faa35ceb89ccd2979072286f063687c9f846ce3
ToppCell	droplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS15 ARHGEF17 ADAMTSL2	1.86e-04	185	27	3	40e958511790e84321da5ccf735f9974c06a0263
ToppCell	droplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS15 ARHGEF17 ADAMTSL2	1.86e-04	185	27	3	5f2eeba80aff145e85cfd81e2890a155406badb9
ToppCell	droplet-Liver-LIVER_HEP-30m-Mesenchymal\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS15 ARHGEF17 ADAMTSL2	1.86e-04	185	27	3	f814ec9d4ade717a0109398e9768d0d66f09317b
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-Pericytes-Pericyte\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTS12 ANGPT2 ARHGEF17	1.89e-04	186	27	3	0c477016c1b539b3086a8066c3c6443f08c222a3
ToppCell	RV-07._Pericyte\|World / Chamber and Cluster_Paper	ADAMTS12 ARHGEF17 ADGRA2	1.92e-04	187	27	3	dc274d6bbda619a2c914d84e2b4069cfef1739d1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 UHRF1 ADGRA2	1.92e-04	187	27	3	e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|lymph-node_spleen / Manually curated celltypes from each tissue	PROK2 UHRF1 ADGRA2	1.92e-04	187	27	3	3c10b8501226c69d71bcd99dc1c064a3c2154f87
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 UHRF1 ADGRA2	1.92e-04	187	27	3	cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ANGPT2 ARHGEF17 ADGRA2	1.92e-04	187	27	3	a2bf958ea59c359a265bfa437d59315e1920cdd4
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ARHGEF17 ADGRA2 ADAMTSL2	1.95e-04	188	27	3	ccddc08121caff958a2b6f9e278a018858af6b4d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ANGPT2 ARHGEF17 ADGRA2	1.98e-04	189	27	3	7fbe855bfdb47d35e040b04a80fe4b729a3764e8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ADGRA2 ADAMTSL2	1.98e-04	189	27	3	71397e993a77d70b2eeede240bdfc7660b558987
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS15 TMTC2 ZFAND3	1.98e-04	189	27	3	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ADGRA2 ADAMTSL2	1.98e-04	189	27	3	4eea4759520c312bd17a681034d8074e47093d2b
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-Pericytes\|Fibroblasts / Location, Cell class and cell subclass	ANGPT2 ARHGEF17 ADGRA2	1.98e-04	189	27	3	f4865b7db16de15120504147a8016ac522ad242a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ANGPT2 ARHGEF17 ADGRA2	1.98e-04	189	27	3	06b35abecd29f902cf251fcc1f6ad33db7ab08a2
ToppCell	facs-Lung-EPCAM-24m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS15 ARHGEF17 ADAMTSL2	2.01e-04	190	27	3	00fd993675faf53adf985b9316a18c8a33242029
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ARHGEF17 ADGRA2	2.01e-04	190	27	3	70c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-intestinal_crypt_stem_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAP1L1 KCNN4 ANGPT2	2.01e-04	190	27	3	52c59001a079c76249abbaa3141e9e661b83d9a0
ToppCell	facs-Lung-EPCAM-24m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS15 ARHGEF17 ADAMTSL2	2.01e-04	190	27	3	8cda09d761c6b504a744959d587c183f94f1beeb
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ADGRA2 ADAMTSL2	2.04e-04	191	27	3	39092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ADGRA2 ADAMTSL2	2.04e-04	191	27	3	107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ADGRA2 ADAMTSL2	2.04e-04	191	27	3	bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ADGRA2 ADAMTSL2	2.04e-04	191	27	3	806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ADGRA2 ADAMTSL2	2.04e-04	191	27	3	ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCell	droplet-Limb_Muscle-nan-18m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS15 ANGPT2 ARHGEF17	2.08e-04	192	27	3	88472b99970ba0decbf87164fc241a1c77b3b389
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS20 TMTC2 PSKH2	2.08e-04	192	27	3	bd3fa6c8fcb618db64d11f25cabaf08608957c35
ToppCell	E15.5\|World / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	NAP1L1 UHRF1 PARP1	2.08e-04	192	27	3	4a0fb4ef8a9281489ffb0881421c9d691c52019c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ADGRA2 ADAMTSL2	2.08e-04	192	27	3	d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCell	droplet-Large_Intestine-COLON:P+D-30m-Epithelial-Lgr5+_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAP1L1 KCNN4 UHRF1	2.08e-04	192	27	3	5155f746ad57122ef735da776c96721005b8dadc
ToppCell	Healthy_donor-B_intermediate\|World / disease group, cell group and cell class (v2)	ADAMTS19 PARP1 WNT16	2.08e-04	192	27	3	f77007b284e11f8654ad599eef929df7c6c4ebf0
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-1\|TCGA-Endometrium / Sample_Type by Project: Shred V9	UHRF1 ADAMTS19 ACAT2	2.11e-04	193	27	3	c2673d86f7d7b849788036032a93a6d136a70040
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ANGPT2 ARHGEF17 ADGRA2	2.11e-04	193	27	3	dd4bac8a93a5b9dcf7301f1d7d6e3eb6670f5c68
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ADGRA2 ADAMTSL2	2.11e-04	193	27	3	f1199518c3626fd29bfce65070dd21a660671213
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ANGPT2 ARHGEF17 ADGRA2	2.11e-04	193	27	3	2ddf9b2770a0be9689e01d1a3d19e4a6d42c7a50
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADAMTS12 ADAMTS15 ADAMTSL2	2.11e-04	193	27	3	99525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADAMTS12 ADAMTS15 ADAMTSL2	2.11e-04	193	27	3	b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCell	metastatic_Brain-Fibroblasts-Pericytes\|metastatic_Brain / Location, Cell class and cell subclass	ANGPT2 ARHGEF17 ADGRA2	2.14e-04	194	27	3	d1889a3e22d5b88461c81ec3ea0e74bb9bf63e60
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADAMTS12 ADAMTS15 ADAMTSL2	2.14e-04	194	27	3	e93de9428c986b8943fc169258847c650cfab0e5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ADGRA2 ADAMTSL2	2.14e-04	194	27	3	ba7f971fb9a19423602da60770f23d9fead4a451
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ADGRA2 ADAMTSL2	2.14e-04	194	27	3	cf0244a29934e515446ac917d3c30672b460fb04
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_prolif-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ADAMTS12 ARHGEF17 ADGRA2	2.14e-04	194	27	3	a7731378f44ca1a229311686caf5740c742d21ba
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NAP1L1 ADAMTS12 ADAMTSL2	2.17e-04	195	27	3	dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS12 ADAMTS15 ANGPT2	2.17e-04	195	27	3	c51b1bee79e77aa2ac444a4883ef533c0095eaad
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ADGRA2 ADAMTSL2	2.17e-04	195	27	3	d8ebb94f30d4a655d6b29dd6a3076be2403d2356
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ADGRA2 ADAMTSL2	2.17e-04	195	27	3	edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 ADGRA2 ADAMTSL2	2.17e-04	195	27	3	d9a5c75d31c6e8bb1e1ab7fd115ac5deb5fb1c8d
Computational	Genes upregulated in subsets of cells of a given type within various tumors	TMPRSS2 KLK3 KLK2	2.62e-05	50	13	3	GAVISH_3CA_METAPROGRAM_EPITHELIAL_ANDROGEN_PROSTATE
Computational	Serine proteases.	TMPRSS2 KLK2	9.76e-04	39	13	2	MODULE_109
Drug	merbarone	TMPRSS2 KLK3 KLK2	5.94e-09	4	27	3	ctd:C045459
Drug	tegafur	ADAMTS12 ADAMTS15 ADAMTS20 ADAMTS19	3.20e-07	49	27	4	CID000005386
Drug	Ro 15-8074/001	PROK2 ARHGEF17 ADGRA2	1.20e-06	18	27	3	CID005486821
Drug	palbociclib	UHRF1 TMPRSS2 PARP1 KLK3 KLK2	1.59e-06	171	27	5	ctd:C500026
Drug	Dutasteride	TMPRSS2 KLK3 KLK2	1.95e-06	21	27	3	ctd:D000068538
Drug	Ngp 1-01	KCNN4 KLK3	8.11e-06	4	27	2	CID000036381
Drug	decursin	PARP1 KLK3	8.11e-06	4	27	2	ctd:C101278
Drug	phentin acetate	TMPRSS2 KLK3	2.03e-05	6	27	2	ctd:C011978
Drug	Goserelin	TMPRSS2 KLK3	4.85e-05	9	27	2	ctd:D017273
Drug	Clorgyline hydrochloride [17780-75-5]; Up 200; 13uM; MCF7; HT_HG-U133A	ADAMTS12 TMPRSS2 ARHGEF17 ADGRA2	7.54e-05	193	27	4	5005_UP
Drug	Piribedil hydrochloride [78213-63-5]; Up 200; 12uM; MCF7; HT_HG-U133A	ADAMTS20 TMPRSS2 ANGPT2 ARHGEF17	8.16e-05	197	27	4	3512_UP
Drug	AgCl	PROK2 KLK3	8.87e-05	12	27	2	CID005460490
Drug	6-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(6-methylpyridin-2-yl)nicotinamide	PARP1 KLK3	8.87e-05	12	27	2	ctd:C576268
Drug	methylseleninic acid	PARP1 KLK3 KLK2	1.07e-04	78	27	3	CID000161597
Disease	middle cerebral artery infarction (implicated_via_orthology)	KCNN4 PARP1	7.79e-04	45	27	2	DOID:3525 (implicated_via_orthology)
Disease	Prostatic Neoplasms	TMPRSS2 PARP1 KLK3 KLK2	2.25e-03	616	27	4	C0033578
Disease	Malignant neoplasm of prostate	TMPRSS2 PARP1 KLK3 KLK2	2.25e-03	616	27	4	C0376358
Disease	central corneal thickness	ADAMTS15 ADAMTS20 ADAMTS19	2.76e-03	309	27	3	EFO_0005213
Disease	Colorectal Carcinoma	ADAMTS15 PARP1 WNT16 CCDC93	3.61e-03	702	27	4	C0009402
Disease	type 2 diabetes mellitus (implicated_via_orthology)	ADAMTS20 PARP1	4.15e-03	105	27	2	DOID:9352 (implicated_via_orthology)
Disease	cutaneous melanoma	ADAMTS12 PARP1	5.47e-03	121	27	2	EFO_0000389
Disease	cancer	PARP1 KLK3 KLK2	5.68e-03	400	27	3	MONDO_0004992
Disease	type 2 diabetes mellitus (is_marker_for)	PARP1 ANGPT2	6.86e-03	136	27	2	DOID:9352 (is_marker_for)
Disease	corneal resistance factor	ADAMTS15 ADAMTS20 ADAMTS19	7.90e-03	451	27	3	EFO_0010067
Disease	gait measurement	UHRF1 KLK2	8.29e-03	150	27	2	EFO_0007680
Disease	prostate carcinoma	TMPRSS2 TMTC2 KLK3 KLK2	8.33e-03	891	27	4	EFO_0001663

Protein segments in the cluster

Peptide	Gene	Start	Entry
VASGGCMKTGLWKSE	ADGRA2	1321	Q96PE1
DKCICKCSQMLTGGW	ANGPT2	431	O15123
DGTQCGEKKWCMAGK	ADAMTS12	516	P58397
GEKKWCMAGKCITVG	ADAMTS12	521	P58397
TKLWCTGKAKGQMVC	ADAMTS15	466	Q8TE58
GKWSKCSVTCGIGIM	ADAMTS20	1661	P59510
TEGWKCMAGRGTCIA	PATE4	31	P0C8F1
WSKCSITCGKGMQSR	ADAMTS19	1096	Q8TE59
EIMGCTGCQIDWKKG	NAP1L1	251	P55209
CTGDVTAWTKCMVKT	PARP1	311	P09874
ITKMVSVGGRLWCGC	ARHGEF17	1821	Q96PE2
MLCAGLWTGGKDTCG	KLK2	196	P20151
GKKSGDWTMKTLCGT	PSKH2	211	Q96QS6
MWGKIVCLCTGVMGV	KCNN4	261	O15554
GCVAMSTGKSVGKWE	LY75	596	O60449
PWSECTKTCGVGVRM	ADAMTSL2	861	Q86TH1
GGGMCCAVSIWVKSI	PROK2	41	Q9HC23
DKVVGGMTWCITTCN	CCDC93	51	Q567U6
QVTPVMKCWGKSGRC	DEFB121	16	Q5J5C9
WKFMGSKCSNSGIEC	TMPRSS2	106	O15393
WSCQMICGSGLKAVC	ACAT2	86	Q9BWD1
GLCAGCSMLWKEQGV	TMTC2	176	Q8N394
VSGSCAVKTCWKTMS	WNT16	226	Q9UBV4
DWGKGMACVGRTKEC	UHRF1	396	Q96T88
SNWAVCGKSCGVISM	TRAPPC10	1121	P48553
GFWGSSKTMNLCSKC	ZFAND3	21	Q9H8U3
WTGVCTKKVHLWGMC	ZNF776	81	Q68DI1
KVTKFMLCAGRWTGG	KLK3	191	P07288
MLCAGRWTGGKSTCS	KLK3	196	P07288