Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessphosphatidylserine exposure on apoptotic cell surface

XKR4 XKR7 XKR6

1.71e-0712203GO:0070782
GeneOntologyBiologicalProcessengulfment of apoptotic cell

XKR4 XKR7 XKR6

3.52e-0715203GO:0043652
GeneOntologyBiologicalProcessplasma membrane phospholipid scrambling

XKR4 XKR7 XKR6

2.00e-0626203GO:0017121
GeneOntologyBiologicalProcessapoptotic process involved in development

XKR4 XKR7 XKR6

1.23e-0547203GO:1902742
GeneOntologyBiologicalProcessapoptotic cell clearance

XKR4 XKR7 XKR6

1.31e-0548203GO:0043277
GeneOntologyBiologicalProcessphospholipid translocation

XKR4 XKR7 XKR6

1.98e-0555203GO:0045332
GeneOntologyBiologicalProcesslipid translocation

XKR4 XKR7 XKR6

2.58e-0560203GO:0034204
GeneOntologyBiologicalProcessregulation of membrane lipid distribution

XKR4 XKR7 XKR6

3.28e-0565203GO:0097035
GeneOntologyBiologicalProcessphagocytosis, engulfment

XKR4 XKR7 XKR6

3.92e-0569203GO:0006911
GeneOntologyBiologicalProcessplasma membrane invagination

XKR4 XKR7 XKR6

5.66e-0578203GO:0099024
GeneOntologyBiologicalProcessmembrane invagination

XKR4 XKR7 XKR6

7.85e-0587203GO:0010324
GeneOntologyBiologicalProcessphospholipid transport

XKR4 XKR7 XKR6

1.41e-04106203GO:0015914
GeneOntologyBiologicalProcessexecution phase of apoptosis

XKR4 XKR7 XKR6

1.49e-04108203GO:0097194
GeneOntologyBiologicalProcessorganophosphate ester transport

XKR4 XKR7 XKR6

4.91e-04162203GO:0015748
GeneOntologyBiologicalProcesspositive regulation of dendritic spine morphogenesis

DHX36 AFDN

4.92e-0434202GO:0061003
GeneOntologyBiologicalProcessregulation of postsynapse organization

DHX36 AFDN NCAN

7.23e-04185203GO:0099175
GeneOntologyBiologicalProcessplasma membrane organization

XKR4 XKR7 XKR6

7.58e-04188203GO:0007009
GeneOntologyBiologicalProcessregulation of programmed necrotic cell death

ASAH1 MUTYH

7.88e-0443202GO:0062098
GeneOntologyBiologicalProcessregulation of dendritic spine morphogenesis

DHX36 AFDN

1.74e-0364202GO:0061001
GeneOntologyBiologicalProcesspositive regulation of dendrite morphogenesis

DHX36 AFDN

1.90e-0367202GO:0050775
GeneOntologyBiologicalProcessprogrammed necrotic cell death

ASAH1 MUTYH

1.96e-0368202GO:0097300
GeneOntologyBiologicalProcesspolyol biosynthetic process

CYP2R1 ASAH1

2.02e-0369202GO:0046173
GeneOntologyBiologicalProcesspositive regulation of cell morphogenesis

DHX36 AFDN

2.02e-0369202GO:0010770
GeneOntologyBiologicalProcesspositive regulation of dendritic spine development

DHX36 AFDN

2.07e-0370202GO:0060999
GeneOntologyBiologicalProcessphagocytosis

XKR4 XKR7 XKR6

2.24e-03274203GO:0006909
HumanPhenoIrritability

CYP2R1 ASAH1 DISP1 MUTYH

3.98e-0527554HP:0000737
DomainXK_rel

XKR4 XKR7 XKR6

1.72e-0711203IPR018629
DomainXK-related

XKR4 XKR7 XKR6

1.72e-0711203PF09815
Pubmed

Exposure of phosphatidylserine by Xk-related protein family members during apoptosis.

XKR4 XKR7 XKR6

2.27e-081021325231987
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

RBBP6 AFDN MATR3 NSD3

2.97e-0454921438280479
Pubmed

A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.

DHX36 RBBP6 MATR3

4.64e-0425421328431233
Pubmed

Common variants at 30 loci contribute to polygenic dyslipidemia.

NCAN XKR6

4.88e-045421219060906
Pubmed

Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.

DHX36 MATR3

5.43e-045721217932509
Pubmed

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.

DHX36 RBBP6 MATR3

5.79e-0427421334244482
GeneFamilyBlood group antigens|XK related family

XKR4 XKR7 XKR6

4.78e-0811133955
ToppCellSevere-B_intermediate-1|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

CFAP97D1 MATR3 NSD3

1.88e-051112137021009545178fac1f19f3c429bfedb2f38b680d
ToppCellSevere-B_intermediate-1|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

AFDN MATR3 NSD3

2.75e-0512621342a0bdbe18ef85146cac4e86b2b27d0b3b20d8a2
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AFDN MATR3 NSD3

3.38e-051352137743a01dc9c4542e910e7c0fe046004692a680bf
ToppCellControl-B_intermediate-1|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

AFDN MATR3 NSD3

4.09e-05144213984470ff6ddce4c743e2db78fa98dae055aaa273
ToppCellTuft-tuft-3|World / Class top

XKR4 DISP1 XKR6

4.44e-05148213f4f59b46a79fc9aa4c5d330a7b37b1a34a6d71cc
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ACOT11 XKR7 XKR6

5.29e-051572134183dbed6b31ebe13ef33eb19ba6d0fb4f625953
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

ACOT11 XKR7 XKR6

5.39e-05158213de65af8d3b8514b17978155f31975e2347b75251
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_neural-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

AFDN XKR7 NCAN

5.71e-05161213bd520c9a1927d5d5355b4421e6b90b58bfb76a42
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage|343B / Donor, Lineage, Cell class and subclass (all cells)

ACOT11 XKR7 XKR6

6.03e-05164213057ca87847373eff7fe97dd9f4358509e66ca4c3
ToppCellControl-B_intermediate-1|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

AFDN MATR3 NSD3

6.36e-05167213948504367ecf58144d9dd74d2ec531358fc4b309
ToppCellPCW_13-14-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

XKR4 CFAP97D1 XKR7

7.81e-05179213af0b54c9ea0b6e4210f22dbb6e88ecd3276a5f86
ToppCell15-Distal-Epithelial-Epithelial|Distal / Age, Tissue, Lineage and Cell class

XKR4 CCDC26 XKR6

7.94e-0518021399e2db9ad8e09fedc3542233553acece69f579f1
ToppCellCOVID-19_Mild-CD4+_T_activated|COVID-19_Mild / Disease condition and Cell class

AFDN MATR3 NSD3

8.21e-05182213877b6e611626628e709568747512f2827ebb2795
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AFDN MATR3 NSD3

8.21e-05182213c0f63cfc67d61c0877b7acb2946dfb35aae8a8f5
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AFDN MATR3 NSD3

8.21e-051822134cb182ef39be2044a6ad7266f332d4177591e550
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ACOT11 TMEM178A XKR6

8.34e-051832132e831a4d99c6f983793df71c0994124c943c6da9
ToppCellBrain_organoid-organoid_Kanton_Nature|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.

DHX36 AFDN NSD3

8.61e-05185213857c7ca8493e91ef1d0078ddafd6082020f9b169
ToppCell3'_v3-Lung-Myeloid_Dendritic-Cycling_Dendritic|Lung / Manually curated celltypes from each tissue

B3GNT6 AFDN CCDC26

9.03e-051882130e8ac42c439f30a05e015210e1d5c2dcb9d9d471
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

XKR4 TMEM178A XKR6

1.05e-041982134ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell(10)_Ciliated-(2)_GFP_FOXI1|(10)_Ciliated / shred by cell type by condition

RBBP6 SCRN1 ANKRD18A

1.07e-0419921361b1ed2db71b96157b92b7535d1955a4033098da
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

RBBP6 SCRN1 MATR3

1.07e-04199213fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

SCRN1 MATR3 NSD3

1.07e-04199213c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell(01)_IL1RL1+-(2)_GFP_FOXI1|(01)_IL1RL1+ / shred by cell type by condition

RBBP6 ANKRD18A NSD3

1.07e-04199213a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Neuronal-Neuron|2m / Sample Type, Dataset, Time_group, and Cell type.

TMEM178A AFDN NCAN

1.08e-04200213a581f1704a87b0390e1e2ff85053367d85247755
ComputationalGenes in the cancer module 568.

ASAH1 MUTYH

1.24e-037382MODULE_568
ComputationalGenes in the cancer module 491.

ASAH1 MUTYH

1.45e-037982MODULE_491
Diseaselip morphology measurement

CFAP97D1 RBBP6 CCDC26

3.16e-04189213EFO_0007845
Diseaseosteoarthritis

XKR4 CCDC26 XKR6

5.06e-04222213MONDO_0005178
Diseasecorpus callosum posterior volume measurement

CCDC26 XKR6

6.26e-0452212EFO_0010298
Diseaseendometriosis

XKR4 CCDC26 XKR6

7.31e-04252213EFO_0001065
Diseasefree cholesterol:total lipids ratio, intermediate density lipoprotein measurement

CFAP97D1 XKR6

1.70e-0386212EFO_0008595, EFO_0020945
Diseasefatty acid measurement

CFAP97D1 NCAN XKR6

3.50e-03436213EFO_0005110
Diseasehemorrhoid

CCDC26 MUC12

4.86e-03147212EFO_0009552
Diseaselow density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

NCAN XKR6

5.26e-03153212EFO_0004611, EFO_0020944
Diseasebody fat distribution

CCDC26 XKR6

8.99e-03202212EFO_0004341
Diseaseneutrophil count, eosinophil count

CCDC26 XKR6

9.95e-03213212EFO_0004833, EFO_0004842
Diseasefree cholesterol measurement, very low density lipoprotein cholesterol measurement

CFAP97D1 NCAN

1.01e-02215212EFO_0008317, EFO_0008591
Diseasevery low density lipoprotein cholesterol measurement, lipid measurement

CFAP97D1 NCAN

1.06e-02220212EFO_0004529, EFO_0008317
Diseasetriglyceride measurement, very low density lipoprotein cholesterol measurement

CFAP97D1 NCAN

1.10e-02224212EFO_0004530, EFO_0008317
Diseaseneutrophil count, basophil count

CCDC26 XKR6

1.10e-02224212EFO_0004833, EFO_0005090
Diseasetotal cholesterol measurement, very low density lipoprotein cholesterol measurement

CFAP97D1 NCAN

1.10e-02224212EFO_0004574, EFO_0008317
Diseasecholesteryl ester measurement, very low density lipoprotein cholesterol measurement

CFAP97D1 NCAN

1.10e-02225212EFO_0008317, EFO_0010351
Diseasevery low density lipoprotein cholesterol measurement, phospholipid measurement

CFAP97D1 NCAN

1.14e-02229212EFO_0004639, EFO_0008317

Protein segments in the cluster

PeptideGeneStartEntry
AAERRKREEHQRWYE

AFDN

1406

P55196
PGYDIRDWELRKIHR

ANKRD18A

26

Q8IVF6
LRQRPEWDKHYRSVE

ACOT11

446

Q8WXI4
YDRWKHPFFLDDRRT

ASAH1

321

Q13510
RDDRWSDDHYEREKR

DISP1

266

Q96F81
YRVPRDDWEEKRHFR

MATR3

171

P43243
VDFRDPFEKERYREW

RBBP6

816

Q7Z6E9
PFEKERYREWERKYR

RBBP6

821

Q7Z6E9
YLPHWERSSRDREEK

CCDC26

16

Q8TAB7
EKYWRDPEVFHPERF

CYP2R1

411

Q6VVX0
WEEARRRGFRYEKDY

DHX36

766

Q9H2U1
AKRARQEFPWEEEYR

C1orf112

791

Q9NSG2
DRKPHYDRRASEIDW

CFAP97D1

131

B2RV13
APEHYERRELIRRTW

B3GNT6

126

Q6ZMB0
WYETDPRRHKESCER

TMEM178A

31

Q8NBL3
RYFAHRRAWEDAEKD

NCAN

1101

O14594
YDQEKRDLPWRRRAE

MUTYH

101

Q9UIF7
PDRRHELYKAHEWAR

SCRN1

341

Q12765
RKRYPAWDAHFVDRR

XKR6

591

Q5GH73
KYPAWDAHFIDRRLR

XKR7

531

Q5GH72
KIDLFRNRYPAWERH

XKR4

596

Q5GH76
QPERAWVHEKRVREY

NSD3

316

Q9BZ95
RKRHREQYDVPQEWR

MUC12

5406

Q9UKN1