Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	receptor localization to synapse	NPTN RELN RAP1A KALRN ANKS1B DAG1	3.80e-06	101	85	6	GO:0097120
GeneOntologyBiologicalProcess	protein localization to synapse	RELN RAP1A KALRN DAG1 BAIAP2 RAB27B	8.05e-06	115	85	6	GO:0035418
GeneOntologyBiologicalProcess	regulation of receptor localization to synapse	NPTN RAP1A KALRN DAG1	1.98e-05	39	85	4	GO:1902683
GeneOntologyBiologicalProcess	positive regulation of canonical NF-kappaB signal transduction	NDFIP2 RFPL1 NFAT5 RFPL3 RFPL2 NDFIP1 TFRC	2.83e-05	213	85	7	GO:0043123
GeneOntologyBiologicalProcess	regulation of canonical NF-kappaB signal transduction	NDFIP2 PLCG2 RFPL1 NFAT5 RFPL3 RFPL2 NDFIP1 TFRC	3.17e-05	298	85	8	GO:0043122
GeneOntologyBiologicalProcess	protein localization to cell junction	RELN RAP1A KALRN DAG1 BAIAP2 RAB27B	3.38e-05	148	85	6	GO:1902414
GeneOntologyBiologicalProcess	positive regulation of NF-kappaB transcription factor activity	PRKCQ PLCG2 RFPL1 RFPL3 RFPL2 TFRC	3.79e-05	151	85	6	GO:0051092
GeneOntologyBiologicalProcess	canonical NF-kappaB signal transduction	NDFIP2 PLCG2 RFPL1 NFAT5 RFPL3 RFPL2 NDFIP1 TFRC	6.51e-05	330	85	8	GO:0007249
GeneOntologyBiologicalProcess	symbiont entry into host cell	DAG1 VPS16 RFPL1 RFPL3 RFPL2 TFRC	7.09e-05	169	85	6	GO:0046718
GeneOntologyBiologicalProcess	small GTPase-mediated signal transduction	ARFGEF3 RELN RAP1A DENND4A RAP1B KALRN SH2D3C BAIAP2 DNMBP GARRE1	7.26e-05	538	85	10	GO:0007264
GeneOntologyBiologicalProcess	symbiont entry into host	DAG1 VPS16 RFPL1 RFPL3 RFPL2 TFRC	8.87e-05	176	85	6	GO:0044409
GeneOntologyBiologicalProcess	mitochondrial tRNA 3'-end processing	TRMT10C TRNT1	1.00e-04	4	85	2	GO:1990180
GeneOntologyBiologicalProcess	positive regulation of DNA-binding transcription factor activity	RELN PRKCQ PLCG2 RFPL1 RFPL3 RFPL2 TFRC	1.02e-04	261	85	7	GO:0051091
GeneOntologyBiologicalProcess	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	RAP1A KALRN DAG1	1.45e-04	25	85	3	GO:0098696
GeneOntologyBiologicalProcess	protein-containing complex localization	NPTN RELN RAP1A KALRN ANKS1B DAG1 NME7	1.51e-04	278	85	7	GO:0031503
GeneOntologyBiologicalProcess	negative regulation of synaptic vesicle exocytosis	RAP1A RAP1B	2.49e-04	6	85	2	GO:2000301
GeneOntologyBiologicalProcess	regulation of cell morphogenesis	FMNL3 RELN KALRN PLXNC1 DAG1 BAIAP2 DNMBP	2.50e-04	302	85	7	GO:0022604
GeneOntologyBiologicalProcess	negative regulation of T cell apoptotic process	BLM PRKCQ PNP	3.07e-04	32	85	3	GO:0070233
GeneOntologyBiologicalProcess	mitochondrial RNA 3'-end processing	TRMT10C TRNT1	3.48e-04	7	85	2	GO:0000965
GeneOntologyBiologicalProcess	biological process involved in interaction with host	DAG1 VPS16 RFPL1 RFPL3 RFPL2 TFRC	3.61e-04	228	85	6	GO:0051701
GeneOntologyBiologicalProcess	positive regulation of dendritic spine morphogenesis	RELN KALRN BAIAP2	3.69e-04	34	85	3	GO:0061003
GeneOntologyBiologicalProcess	regulation of DNA recombination	BLM PMS2 UBQLN4 NDFIP1 TFRC	3.91e-04	150	85	5	GO:0000018
GeneOntologyBiologicalProcess	tRNA 3'-end processing	TRMT10C TRNT1	4.62e-04	8	85	2	GO:0042780
GeneOntologyBiologicalProcess	regulation of cell shape	FMNL3 PLXNC1 DAG1 BAIAP2 DNMBP	5.10e-04	159	85	5	GO:0008360
GeneOntologyBiologicalProcess	viral life cycle	DAG1 VPS16 RFPL1 ZFYVE1 RFPL3 RFPL2 TFRC	5.10e-04	340	85	7	GO:0019058
GeneOntologyBiologicalProcess	regulation of protein localization to synapse	RAP1A KALRN DAG1	5.13e-04	38	85	3	GO:1902473
GeneOntologyCellularComponent	germ cell nucleus	BLM CELF1 RFPL1 RFPL3 RFPL2	1.04e-04	113	86	5	GO:0043073
GeneOntologyCellularComponent	female germ cell nucleus	RFPL1 RFPL3 RFPL2	2.78e-04	31	86	3	GO:0001674
Domain	RDM	RFPL1 RFPL3 RFPL2	9.04e-07	5	85	3	PF11002
Domain	RDM_domain_RFPL	RFPL1 RFPL3 RFPL2	9.04e-07	5	85	3	IPR022723
Domain	NEDD4/Bsd2	NDFIP2 NDFIP1	2.05e-05	2	85	2	IPR019325
Domain	DUF2370	NDFIP2 NDFIP1	2.05e-05	2	85	2	PF10176
Domain	PRY	RFPL1 RFPL3 RFPL2	9.19e-04	42	85	3	PF13765
Domain	PRY	RFPL1 RFPL3 RFPL2	1.36e-03	48	85	3	SM00589
Domain	PRY	RFPL1 RFPL3 RFPL2	1.36e-03	48	85	3	IPR006574
Domain	A/G_cyclase_CS	GUCY1B1 ADCY6	2.66e-03	17	85	2	IPR018297
Domain	Nucleotide_cyclase	GUCY1B1 ADCY6	2.99e-03	18	85	2	IPR029787
Domain	-	GUCY1B1 ADCY6	2.99e-03	18	85	2	3.30.70.1230
Domain	GUANYLATE_CYCLASE_1	GUCY1B1 ADCY6	3.33e-03	19	85	2	PS00452
Domain	Guanylate_cyc	GUCY1B1 ADCY6	3.33e-03	19	85	2	PF00211
Domain	GUANYLATE_CYCLASE_2	GUCY1B1 ADCY6	3.33e-03	19	85	2	PS50125
Domain	A/G_cyclase	GUCY1B1 ADCY6	3.33e-03	19	85	2	IPR001054
Domain	CYCc	GUCY1B1 ADCY6	3.33e-03	19	85	2	SM00044
Domain	Butyrophylin	RFPL1 RFPL3 RFPL2	4.00e-03	70	85	3	IPR003879
Pubmed	Evolutionary forces shape the human RFPL1,2,3 genes toward a role in neocortex development.	RFPL1 RFPL3 RFPL2	1.46e-08	3	86	3	18656177
Pubmed	Duplications on human chromosome 22 reveal a novel Ret Finger Protein-like gene family with sense and endogenous antisense transcripts.	RFPL1 RFPL3 RFPL2	1.45e-07	5	86	3	10508838
Pubmed	The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells.	RFPL1 RFPL3 RFPL2	1.45e-07	5	86	3	11850190
Pubmed	RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway.	RFPL1 RFPL3 RFPL2	8.10e-07	8	86	3	12525704
Pubmed	Rap1A and rap1B ras-family proteins are prominently expressed in the nucleus of squamous carcinomas: nuclear translocation of GTP-bound active form.	RAP1A RAP1B	6.04e-06	2	86	2	13679863
Pubmed	Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function.	RAP1A RAP1B	6.04e-06	2	86	2	25807985
Pubmed	Rap1 Is Essential for B-Cell Locomotion, Germinal Center Formation and Normal B-1a Cell Population.	RAP1A RAP1B	6.04e-06	2	86	2	34140948
Pubmed	NKCC2A and NFAT5 regulate renal TNF production induced by hypertonic NaCl intake.	SLC12A1 NFAT5	6.04e-06	2	86	2	23269645
Pubmed	Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier.	RAP1A RAP1B	6.04e-06	2	86	2	29222111
Pubmed	Purification and characterization of the 22,000-dalton GTP-binding protein substrate for ADP-ribosylation by botulinum toxin, G22K.	RAP1A RAP1B	6.04e-06	2	86	2	3141412
Pubmed	Enhanced cortico-amygdala efficacy and suppressed fear in absence of Rap1.	RAP1A RAP1B	6.04e-06	2	86	2	18305243
Pubmed	Differential regulation of NFAT5 by NKCC2 isoforms in medullary thick ascending limb (mTAL) cells.	SLC12A1 NFAT5	6.04e-06	2	86	2	21228109
Pubmed	RNA-binding protein CELF1 enhances cell migration, invasion, and chemoresistance by targeting ETS2 in colorectal cancer.	CELF1 ETS2	6.04e-06	2	86	2	32677671
Pubmed	Mutation in RAP1 is a rare event in myelodysplastic syndromes.	RAP1A RAP1B	6.04e-06	2	86	2	16118622
Pubmed	Mutation analysis of RAP1 gene in papillary thyroid carcinomas.	RAP1A RAP1B	6.04e-06	2	86	2	18948674
Pubmed	Expression of Rap 1 suppresses genomic instability of H-ras transformed mouse fibroblasts.	RAP1A RAP1B	6.04e-06	2	86	2	9330640
Pubmed	Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo.	RAP1A RAP1B	6.04e-06	2	86	2	24039860
Pubmed	The Rap1 small GTPase is a critical mediator of the effects of stress on prefrontal cortical dysfunction.	RAP1A RAP1B	6.04e-06	2	86	2	32651478
Pubmed	Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition.	RAP1A RAP1B	6.04e-06	2	86	2	31403469
Pubmed	Promoting role of circ-Jarid2/miR-129-5p/Celf1 axis in cardiac hypertrophy.	JARID2 CELF1	6.04e-06	2	86	2	32632266
Pubmed	Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis.	RAP1A RAP1B	6.04e-06	2	86	2	18805968
Pubmed	Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo.	RAP1A RAP1B	6.04e-06	2	86	2	26804993
Pubmed	Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability.	RAP1A RAP1B	6.04e-06	2	86	2	32184389
Pubmed	The rap GTPases regulate B cell morphology, immune-synapse formation, and signaling by particulate B cell receptor ligands.	RAP1A RAP1B	6.04e-06	2	86	2	18191594
Pubmed	Elevated Vasodilatory Cyclases and Shorter Telomere Length Contribute to High-Altitude Pulmonary Edema.	GUCY1B1 ADCY6	6.04e-06	2	86	2	29443612
Pubmed	Chromosome mapping of the human RAS-related RAP1A, RAP1B, and RAP2 genes to chromosomes 1p12----p13, 12q14, and 13q34, respectively.	RAP1A RAP1B	6.04e-06	2	86	2	2108841
Pubmed	Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins.	RAP1A RAP1B	6.04e-06	2	86	2	18056377
Pubmed	Sequential expression of NKCC2, TonEBP, aldose reductase, and urea transporter-A in developing mouse kidney.	SLC12A1 NFAT5	6.04e-06	2	86	2	16926446
Pubmed	Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis.	RAP1A RAP1B	6.04e-06	2	86	2	30796637
Pubmed	Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions.	RAP1A RAP1B	6.04e-06	2	86	2	18625726
Pubmed	Protein kinase A-dependent phosphorylation of Rap1 regulates its membrane localization and cell migration.	RAP1A RAP1B	6.04e-06	2	86	2	23946483
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	ARFGEF3 TRNT1 PLXNC1 ANKS1B BAIAP2 ELFN2	9.87e-06	197	86	6	36604605
Pubmed	Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury.	RAP1A RAP1B	1.81e-05	3	86	2	24642466
Pubmed	Rap1 signaling prevents L-type calcium channel-dependent neurotransmitter release.	RAP1A RAP1B	1.81e-05	3	86	2	23616533
Pubmed	Rap1 small GTPase is essential for maintaining pulmonary endothelial barrier function in mice.	RAP1A RAP1B	1.81e-05	3	86	2	38010922
Pubmed	Small GTPase Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature.	RAP1A RAP1B	1.81e-05	3	86	2	26714318
Pubmed	Large Extracellular Vesicle-Associated Rap1 Accumulates in Atherosclerotic Plaques, Correlates With Vascular Risks and Is Involved in Atherosclerosis.	RAP1A RAP1B	1.81e-05	3	86	2	32539601
Pubmed	Sequential activation of Rap1 and Rac1 small G proteins by PDGF locally at leading edges of NIH3T3 cells.	RAP1A RAP1B	1.81e-05	3	86	2	18422604
Pubmed	Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex.	RELN RAP1A	1.81e-05	3	86	2	21516100
Pubmed	Rap1 and its effector RIAM are required for lymphocyte trafficking.	RAP1A RAP1B	1.81e-05	3	86	2	26324702
Pubmed	Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression.	DUSP5 SERPINB2	1.81e-05	3	86	2	25489104
Pubmed	Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis.	RAP1A RAP1B	1.81e-05	3	86	2	26634692
Pubmed	Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1).	RAP1A RAP1B	1.81e-05	3	86	2	22577140
Pubmed	Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins.	NDFIP2 NDFIP1	1.81e-05	3	86	2	19343052
Pubmed	Differences in the Phosphorylation-Dependent Regulation of Prenylation of Rap1A and Rap1B.	RAP1A RAP1B	1.81e-05	3	86	2	27760305
Pubmed	Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes.	RAP1A RAP1B	1.81e-05	3	86	2	20733035
Pubmed	Purification, identification, and characterization of two GTP-binding proteins with molecular weights of 25,000 and 21,000 in human platelet cytosol. One is the rap1/smg21/Krev-1 protein and the other is a novel GTP-binding protein.	RAP1A RAB27B	1.81e-05	3	86	2	2507536
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	ARFGEF3 RAP1A TRMT10C HCN4 KALRN GUCY1B1 ANKS1B DAG1 UBR3 BAIAP2 ELFN2 CNOT2	2.36e-05	1139	86	12	36417873
Pubmed	Caspase-11 controls interleukin-1β release through degradation of TRPC1.	TRPC1 CASP4	3.61e-05	4	86	2	24630989
Pubmed	Bidirectional Synaptic Structural Plasticity after Chronic Cocaine Administration Occurs through Rap1 Small GTPase Signaling.	RAP1A RAP1B	3.61e-05	4	86	2	26844834
Pubmed	Sema3e/Plexin D1 Modulates Immunological Synapse and Migration of Thymocytes by Rap1 Inhibition.	RAP1A RAP1B	3.61e-05	4	86	2	26921307
Pubmed	Functional redundancy between RAP1 isoforms in murine platelet production and function.	RAP1A RAP1B	3.61e-05	4	86	2	30131434
Pubmed	Deletion of Rap1b, but not Rap1a or Epac1, Reduces Protein Kinase A-Mediated Thyroid Cancer.	RAP1A RAP1B	3.61e-05	4	86	2	29882482
Pubmed	Regulation of the human ether-a-go-go-related gene (hERG) potassium channel by Nedd4 family interacting proteins (Ndfips).	NDFIP2 NDFIP1	3.61e-05	4	86	2	26363003
Pubmed	Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells.	NDFIP2 NDFIP1	3.61e-05	4	86	2	27088444
Pubmed	Rap1 in the VMH regulates glucose homeostasis.	RAP1A RAP1B	3.61e-05	4	86	2	33974562
Pubmed	Differential up-regulation of MAP kinase phosphatases MKP3/DUSP6 and DUSP5 by Ets2 and c-Jun converge in the control of the growth arrest versus proliferation response of MCF-7 breast cancer cells to phorbol ester.	DUSP5 ETS2	3.61e-05	4	86	2	20554528
Pubmed	Rap1 activation plays a regulatory role in pancreatic amylase secretion.	RAP1A RAP1B	3.61e-05	4	86	2	18577515
Pubmed	SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1.	RAP1A RAP1B	3.61e-05	4	86	2	26483383
Pubmed	Docking motif-guided mapping of the interactome of protein phosphatase-1.	ARFGEF3 ZFYVE1 ELFN2 HYDIN	4.78e-05	80	86	4	19389623
Pubmed	Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃.	RAP1A RAP1B	6.01e-05	5	86	2	21636859
Pubmed	Distinct calcium channels regulate responses of primary B lymphocytes to B cell receptor engagement and mechanical stimuli.	TRPC1 PLCG2	6.01e-05	5	86	2	15611229
Pubmed	Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2.	NDFIP2 NDFIP1	6.01e-05	5	86	2	18776082
Pubmed	Suppression of mutant Kirsten-RAS (KRASG12D)-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6.	DUSP5 SERPINB2	6.01e-05	5	86	2	35418690
Pubmed	The critical role of Rap1-GAPs Rasa3 and Sipa1 in T cells for pulmonary transit and egress from the lymph nodes.	RAP1A RAP1B	6.01e-05	5	86	2	37545505
Pubmed	Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair.	BLM PMS2	6.01e-05	5	86	2	19015241
Pubmed	Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling.	RAP1A PLCG2	6.01e-05	5	86	2	21480213
Pubmed	ELAVL2-directed RNA regulatory network drives the formation of quiescent primordial follicles.	RFPL1 RFPL3 RFPL2	6.24e-05	31	86	3	31657143
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	FMNL3 SMG1 RAP1B SHCBP1 U2AF2 BAIAP2 DNMBP	7.26e-05	410	86	7	26949251
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	SLC6A2 PMS2 RAP1B TRNT1 CELF1 ESRP1 DAG1 ZFYVE1 NFAT5 CNOT2 ATP6V0A2	7.42e-05	1084	86	11	11544199
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	RELN PMS2 KALRN GUCY1B1 UBQLN4 ETS2 ANKS1B ZBTB5 USP54 BAIAP2 TUBGCP5 CNOT2	7.54e-05	1285	86	12	35914814
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	CELF1 SERPINB2 U2AF2 HAUS3 BAIAP2 TMCO1 DNMBP ZFYVE1 NNT	7.71e-05	724	86	9	36232890
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	NPTN PLXNC1 DAG1 BAIAP2 ADCY6 RGS12 RAB27B TFRC	8.47e-05	569	86	8	30639242
Pubmed	cDNA cloning, mapping and expression of the mouse propionyl CoA carboxylase beta (pccb), the gene for human type II propionic acidaemia.	TRPC1 DAG1	9.01e-05	6	86	2	11245989
Pubmed	Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia.	RAP1A RAP1B	9.01e-05	6	86	2	36001955
Pubmed	PlexinA2 Forward Signaling through Rap1 GTPases Regulates Dentate Gyrus Development and Schizophrenia-like Behaviors.	RAP1A RAP1B	9.01e-05	6	86	2	29320740
Pubmed	Talin1 and Rap1 are critical for osteoclast function.	RAP1A RAP1B	9.01e-05	6	86	2	23230271
Pubmed	NDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization.	RAP1A RAP1B	9.01e-05	6	86	2	28137909
Pubmed	Small GTPase Rap1A/B Is Required for Lymphatic Development and Adrenomedullin-Induced Stabilization of Lymphatic Endothelial Junctions.	RAP1A RAP1B	9.01e-05	6	86	2	30354217
Pubmed	IL-2 can signal via chemokine receptors to promote regulatory T cells' suppressive function.	RAP1A RAP1B	9.01e-05	6	86	2	37598341
Pubmed	N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.	NDFIP2 NDFIP1	9.01e-05	6	86	2	11748237
Pubmed	Direct Binding of Rap1 to Talin1 and to MRL Proteins Promotes Integrin Activation in CD4+ T Cells.	RAP1A RAP1B	9.01e-05	6	86	2	35197328
Pubmed	Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice.	NPTN HCN4 GUCY1B1	1.07e-04	37	86	3	16707424
Pubmed	NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression.	RFPL1 RFPL3 RFPL2	1.07e-04	37	86	3	15326356
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	RAP1A RAP1B KALRN ECPAS ZFYVE1 NNT	1.11e-04	304	86	6	32235678
Pubmed	Distinct integrin activation pathways for effector and regulatory T cell trafficking and function.	RAP1A RAP1B	1.26e-04	7	86	2	33104169
Pubmed	Dab2IP Regulates Neuronal Positioning, Rap1 Activity and Integrin Signaling in the Developing Cortex.	RAP1A RAP1B	1.26e-04	7	86	2	25721469
Pubmed	Evidence of early defects in Cajal-Retzius cell localization during brain development in a mouse model of dystroglycanopathy.	RELN DAG1	1.26e-04	7	86	2	28039900
Pubmed	RASA3 is a critical inhibitor of RAP1-dependent platelet activation.	RAP1A RAP1B	1.26e-04	7	86	2	25705885
Pubmed	Rap1 regulates lumen continuity via Afadin in renal epithelia.	RAP1A RAP1B	1.26e-04	7	86	2	37276970
Pubmed	Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control.	RAP1A RAP1B	1.26e-04	7	86	2	21840392
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	FMNL3 ARFGEF3 U2AF2 ATP6V0A2 NDFIP1 TFRC	1.30e-04	313	86	6	38270169
Pubmed	Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy.	ZFYVE1 TFRC	1.68e-04	8	86	2	22456507
Pubmed	Ndfip1 expression in developing neurons indicates a role for protein ubiquitination by Nedd4 E3 ligases during cortical development.	RELN NDFIP1	1.68e-04	8	86	2	24036464
Pubmed	Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2.	NDFIP2 NDFIP1	1.68e-04	8	86	2	20534535
Pubmed	Ndfip Proteins Target Robo Receptors for Degradation and Allow Commissural Axons to Cross the Midline in the Developing Spinal Cord.	NDFIP2 NDFIP1	1.68e-04	8	86	2	30893602
Pubmed	Prostaglandin E2 reduces the release and infectivity of new cell-free virions and cell-to-cell HIV-1 transfer.	RAP1A RAP1B	2.15e-04	9	86	2	24586238
Pubmed	Glutamate dehydrogenase in cerebellar mutant mice: gene localization and enzyme activity in different tissues.	RELN PNP	2.15e-04	9	86	2	2293612
Pubmed	Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow.	RAP1A RAP1B	2.15e-04	9	86	2	37267105
Pubmed	Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma.	TMCO1 ITIH1	2.68e-04	10	86	2	25173105
Coexpression	VERHAAK_GLIOBLASTOMA_CLASSICAL	BLM ZFHX4 DAG1 VPS16 GARRE1 RGS12	1.53e-05	161	86	6	M2121
Coexpression	GSE41176_UNSTIM_VS_ANTI_IGM_STIM_BCELL_1H_UP	RAP1B SLC12A1 DUSP5 ETS2 CASP4 NFAT5	4.77e-05	197	86	6	M9917
Coexpression	GSE40274_XBP1_VS_FOXP3_AND_XBP1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN	FMNL3 DUSP5 UBQLN4 ETS2 ADCY6 RGS12	4.90e-05	198	86	6	M9163
Coexpression	GSE24210_IL35_TREATED_VS_UNTREATED_TCONV_CD4_TCELL_DN	JARID2 SMG1 IRAG2 USP54 ITIH1 NDFIP1	5.18e-05	200	86	6	M7850
Coexpression	GSE18281_CORTICAL_THYMOCYTE_VS_WHOLE_CORTEX_THYMUS_DN	PLXNC1 SHCBP1 IRAG2 U2AF2 ECPAS NME7	5.18e-05	200	86	6	M7240
Coexpression	GSE35825_UNTREATED_VS_IFNG_STIM_MACROPHAGE_UP	JARID2 KALRN DUSP5 SERPINB2 CASP4 USP54	5.18e-05	200	86	6	M8657
Coexpression	GSE7852_THYMUS_VS_FAT_TREG_UP	JARID2 ZBTB5 ITGAE NNT CNOT2 ATP6V0A2	5.18e-05	200	86	6	M5743
CoexpressionAtlas	kidney_adult_RenMedVasc_Tie2_k-means-cluster#3_top-relative-expression-ranked_500	FMNL3 SH2D3C ETS2 PRKCQ NFAT5 PNP	7.60e-06	120	83	6	gudmap_kidney_adult_RenMedVasc_Tie2_k3_500
ToppCell	COVID-19-lung-AT2\|lung / Disease (COVID-19 only), tissue and cell type	ARFGEF3 ESRP1 SLC26A9 ZNF385B USP54 RAB27B TTC6	9.01e-08	191	86	7	276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCell	10x5'v1-week_14-16-Hematopoietic-MK\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	RAP1B KALRN GUCY1B1 PRKCQ ADCY6 RAB27B ATP6V0A2	9.01e-08	191	86	7	7edc22e7e70697fb22690699efb352577162709b
ToppCell	10x5'v1-week_14-16-Hematopoietic-MK-early_MK\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	RAP1B KALRN GUCY1B1 PRKCQ ADCY6 RAB27B ATP6V0A2	1.04e-07	195	86	7	9b4f217325afb2efb9c65f298ac87649cb1e1af9
ToppCell	10x3'2.3-week_12-13-Hematopoietic-MK\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	RAP1B KALRN GUCY1B1 PRKCQ ADCY6 RAB27B ATP6V0A2	1.04e-07	195	86	7	1e794839a251fbc6e6ce419b4c457ead35a04735
ToppCell	10x3'2.3-week_12-13-Hematopoietic-MK-early_MK\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	RAP1B KALRN GUCY1B1 PRKCQ ADCY6 RAB27B ATP6V0A2	1.07e-07	196	86	7	fc541e328aed28e84d5b3835169c60da0d64cddc
ToppCell	E16.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DENND4A RAP1B KALRN SERPINB2 PRKCQ RAB27B	1.23e-06	177	86	6	84591e28482ab62a5ef41e61043eb64912766356
ToppCell	E16.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DENND4A RAP1B KALRN SERPINB2 PRKCQ RAB27B	1.23e-06	177	86	6	4bc100062891d07cacd10ffba38966cc6302c92f
ToppCell	E16.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DENND4A RAP1B KALRN SERPINB2 PRKCQ RAB27B	1.23e-06	177	86	6	9f3a2adb9cd4f0a059afc87b6e377a9702154bb1
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARFGEF3 ESRP1 ZNF385B PRKCQ USP54 BAIAP2	1.32e-06	179	86	6	fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell	LPS_only-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARFGEF3 ESRP1 ZNF385B PRKCQ USP54 BAIAP2	1.40e-06	181	86	6	0513b9e6673ff7bf8e72ba123ca3794b65d10170
ToppCell	facs-Skin-Telogen-3m-Epithelial-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAP1B LIPM SERPINB2 ETS2 NDFIP2 RGS12	1.50e-06	183	86	6	26b18d1cc5d98f185176e100bafb9bc9081c66f7
ToppCell	LPS_only-Epithelial_alveolar-AT_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARFGEF3 ESRP1 ZNF385B PRKCQ USP54 BAIAP2	1.50e-06	183	86	6	e972432dd4d1bd31bb0982f4df3061e5e152658f
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARFGEF3 ESRP1 ZNF385B PRKCQ USP54 BAIAP2	1.55e-06	184	86	6	ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCell	COVID-19-kidney-FLT1+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	KALRN DUSP5 ETS2 PLCG2 GARRE1 CNOT2	1.59e-06	185	86	6	673308ca0514a4d3629d61fe91e9d8fb31b72166
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ARFGEF3 ESRP1 ZNF385B USP54 RAB27B TTC6	1.65e-06	186	86	6	2ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARFGEF3 ESRP1 ZNF385B PRKCQ USP54 BAIAP2	1.65e-06	186	86	6	e83718fabb057100835d3357df407f283d23fe16
ToppCell	Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|World / Lineage, Cell type, age group and donor	ARFGEF3 ESRP1 ZNF385B USP54 RAB27B TTC6	1.70e-06	187	86	6	81cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCell	droplet-Lung-nan-18m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 SLC26A9 ZNF385B ITIH1 RAB27B TFRC	1.81e-06	189	86	6	ca657353f2b649530809c0bc057e448adc511ec1
ToppCell	droplet-Lung-nan-18m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 SLC26A9 ZNF385B ITIH1 RAB27B TFRC	1.81e-06	189	86	6	e5325f1c7430b574947f8ee67e425455b60dc518
ToppCell	droplet-Lung-18m-Epithelial-alveolar_epithelial-type_II_pneumocyte-type_2_alveolar_epithelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARFGEF3 SLC26A9 ZNF385B ITIH1 RAB27B TFRC	1.86e-06	190	86	6	a51405f8466fc6d4087873137472619b2e84c1da
ToppCell	COVID-19-lung-AT2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ARFGEF3 ESRP1 SLC26A9 ZNF385B RAB27B TTC6	1.86e-06	190	86	6	27a1a86620fe9b5ee930d388b32352206485e6d0
ToppCell	droplet-Lung-immune-endo-depleted-3m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 ESRP1 SLC26A9 ZNF385B RAB27B TFRC	1.86e-06	190	86	6	aaf5f1c1ff7b1454f4e5dacfeb48e1c3627e3372
ToppCell	droplet-Lung-immune-endo-depleted-3m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 ESRP1 SLC26A9 ZNF385B RAB27B TFRC	1.86e-06	190	86	6	a20123d5c6cb8c2f0dfd99bbfdb571a73c36234d
ToppCell	10x3'2.3-week_17-19-Hematopoietic-MK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	RAP1B KALRN GUCY1B1 PRKCQ ADCY6 RAB27B	1.86e-06	190	86	6	64060e4b56ac9989e659c2d5d2a6b6edeba4d8d4
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-double_negative_T_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JARID2 RAP1A RAP1B PRKCQ BAIAP2 NDFIP1	1.86e-06	190	86	6	84265be128170cbb08d76e824aa108e07da9c3e5
ToppCell	droplet-Lung-18m-Epithelial-alveolar_epithelial-type_II_pneumocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARFGEF3 SLC26A9 ZNF385B ITIH1 RAB27B TFRC	1.86e-06	190	86	6	059beca1c92181b8ba4dcd6fc71ff7530d83d0de
ToppCell	droplet-Lung-18m-Epithelial-alveolar_epithelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARFGEF3 SLC26A9 ZNF385B ITIH1 RAB27B TFRC	1.92e-06	191	86	6	caed913e7ede9f8ae3af273d1ecf375de6c5e813
ToppCell	10x5'v1-week_12-13-Hematopoietic-MK\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	RAP1B KALRN GUCY1B1 PRKCQ ADCY6 RAB27B	2.10e-06	194	86	6	245a3eb6db9c862b73ad34a8cd2898a3688c16f6
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARFGEF3 ESRP1 SLC26A9 ZNF385B PRKCQ USP54	2.10e-06	194	86	6	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	COVID-19-kidney-PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	FMNL3 KALRN DUSP5 SH2D3C ETS2 PLCG2	2.16e-06	195	86	6	a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCell	10x5'v1-week_12-13-Hematopoietic-MK-early_MK\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	RAP1B KALRN GUCY1B1 PRKCQ ADCY6 RAB27B	2.16e-06	195	86	6	fa5fc6f605deb5cae96eec14ba4000b19f877ba6
ToppCell	Control-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	BLM JARID2 PLXNC1 SH2D3C DNMBP NFAT5	2.16e-06	195	86	6	b4444b67a709e82b8e2ee510924c3152cb88b051
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ESRP1 ZNF385B USP54 BAIAP2 TTC6 TFRC	2.29e-06	197	86	6	1485933986921ff45669d9b7501c8d17050b3e97
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / Treatment groups by lineage, cell group, cell type	ARFGEF3 ZNF385B PRKCQ USP54 BAIAP2 TTC6	2.29e-06	197	86	6	1a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCell	10x3'2.3-week_14-16-Hematopoietic-MK-early_MK\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	RAP1B KALRN GUCY1B1 PRKCQ RAB27B ATP6V0A2	2.36e-06	198	86	6	fcf53d6ac2e442400fa0c07c6de72e00a9143ba2
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_dendritic-CD1c-positive_myeloid_dendritic_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	JARID2 DUSP5 ETS2 DNMBP TFRC	1.97e-05	170	86	5	cc66ac6846c58be9493eb270644ee3ce0f86cfea
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Lymphoid_DC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN PLXNC1 DUSP5 OR2T2 ITIH1	2.21e-05	174	86	5	16204ff504b7b382b4d90ca35003ad5336020e07
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ESRP1 SLC26A9 ITIH1 RAB27B TFRC	2.53e-05	179	86	5	bf012825e88626e59cd1deebf67c2cd269ce4829
ToppCell	droplet-Lung-nan-3m-Epithelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZFHX4 ESRP1 ZNF385B ITIH1 RAB27B	2.74e-05	182	86	5	cfba75c1ffc39ac76db9e8e27394731942882b30
ToppCell	droplet-Lung-nan-3m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZFHX4 ESRP1 ZNF385B ITIH1 RAB27B	2.74e-05	182	86	5	d836bfdc298ecd3558a973e393a329eb8bd59d79
ToppCell	5'-Airway_Nasal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FMNL3 PLXNC1 MTMR8 RAB27B ATP6V0A2	2.74e-05	182	86	5	4cd5eb13f78f4f377932c50ac2acb4ac0cd14c12
ToppCell	droplet-Lung-nan-3m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZFHX4 ESRP1 ZNF385B ITIH1 RAB27B	2.74e-05	182	86	5	7e7c7a26460d3003cdf0c0ffb96208a566aa09a7
ToppCell	10x5'v1-week_12-13-Hematopoietic-MK-MK\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	RAP1B KALRN GUCY1B1 ADCY6 RAB27B	2.81e-05	183	86	5	6cbc88c27dc957d182526e84824f70c8e860bf74
ToppCell	10x5'v1-week_17-19-Hematopoietic-MK-MK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	RAP1B KALRN GUCY1B1 ADCY6 RAB27B	2.81e-05	183	86	5	9c66a40c355387f805dbdca4162dd05af5c1d8d4
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 RELN ZFHX4 KALRN HYDIN	2.89e-05	184	86	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	COVID-19-Epithelial_cells-AT2\|COVID-19 / group, cell type (main and fine annotations)	ARFGEF3 ESRP1 SLC26A9 ZNF385B TTC6	2.89e-05	184	86	5	369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCell	10x3'2.3-week_17-19-Hematopoietic-MK-MK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	RAP1B KALRN GUCY1B1 ADCY6 RAB27B	2.89e-05	184	86	5	ba65e3972b2b8d825a2c1a9d03d092cc1afad073
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 RELN ZFHX4 KALRN HYDIN	2.89e-05	184	86	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 RELN ZFHX4 KALRN HYDIN	2.89e-05	184	86	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Adult / Lineage, Cell type, age group and donor	ESRP1 ZNF385B USP54 RAB27B TTC6	2.96e-05	185	86	5	673f0c688ae6984bc8027df2da335787924f4137
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARFGEF3 ESRP1 USP54 RAB27B TTC6	2.96e-05	185	86	5	98b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell	IPF-Epithelial-ATII\|World / Disease state, Lineage and Cell class	ARFGEF3 SLC26A9 ZNF385B USP54 RAB27B	3.04e-05	186	86	5	6a4ff2da0af0f5e590d9f9daa5b5e9ac8c868947
ToppCell	LPS-antiTNF-Epithelial_alveolar\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ESRP1 ZNF385B PRKCQ USP54 BAIAP2	3.12e-05	187	86	5	201ff693e4756ee3e44762885b3a303a77eb535b
ToppCell	10x5'v1-week_17-19-Hematopoietic-MK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	RAP1B KALRN GUCY1B1 ADCY6 RAB27B	3.12e-05	187	86	5	34cad5ac8602fe88ca3d421257190c9a388d4cb0
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ESRP1 ZNF385B PRKCQ USP54 BAIAP2	3.20e-05	188	86	5	43a0508d2524a5b310e89e9422843dcaab999bc3
ToppCell	facs-Lung-EPCAM-3m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 SLC26A9 ZNF385B RAB27B TFRC	3.20e-05	188	86	5	b1049003ca79c340bb8c78da66bdc0956e1aebc2
ToppCell	COVID-19-Epithelial_cells\|COVID-19 / group, cell type (main and fine annotations)	ARFGEF3 ESRP1 ZNF385B USP54 TTC6	3.20e-05	188	86	5	c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARFGEF3 ESRP1 ZNF385B PRKCQ USP54	3.20e-05	188	86	5	4bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCell	facs-Lung-EPCAM-3m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 SLC26A9 ZNF385B RAB27B TFRC	3.20e-05	188	86	5	3dd571bd8e7358b4346dea71f6bf9602dabf583c
ToppCell	10x5'v1-week_17-19-Hematopoietic\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	RAP1B KALRN GUCY1B1 ADCY6 RAB27B	3.20e-05	188	86	5	c00ba0abd0c7bb2c8f9166a2ac6220aae4f4d857
ToppCell	facs-Skin-Telogen-3m-Epithelial-Basal_IFE\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAP1B SERPINB2 ETS2 NDFIP2 RGS12	3.20e-05	188	86	5	8cc927b4c51d982fdafa04dc7393617ad9bb220e
ToppCell	COPD-Myeloid-cMonocyte\|COPD / Disease state, Lineage and Cell class	JARID2 PLXNC1 SERPINB2 ETS2 DNMBP	3.28e-05	189	86	5	d29f3a0bd23e6eb46389e6eb7ef21851c7b57545
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RELN KALRN DUSP5 SH2D3C DNMBP	3.28e-05	189	86	5	0d18ea72bd58d32a8ab9a61cf97f5786642f804b
ToppCell	facs-Skin-nan-18m-Epithelial-Basal_IFE\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A2 SERPINB2 ETS2 CASP4 NDFIP2	3.28e-05	189	86	5	6c71e81373cb7822de23c193a6350b6df9f567bc
ToppCell	COPD-Myeloid-cMonocyte\|Myeloid / Disease state, Lineage and Cell class	JARID2 PLXNC1 SERPINB2 ETS2 DNMBP	3.28e-05	189	86	5	6294691231c7d38707323cf31578a107d3b2c622
ToppCell	droplet-Lung-nan-18m-Epithelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 ESRP1 SLC26A9 ITIH1 RAB27B	3.36e-05	190	86	5	b057bea6e55cef872290893b6e439bbcdcee2f2e
ToppCell	IPF-Myeloid-cMonocyte\|IPF / Disease state, Lineage and Cell class	JARID2 PLXNC1 SERPINB2 ETS2 DNMBP	3.36e-05	190	86	5	a099f51f2b7618b6712af38eedd5ee64d8663a4a
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-Double_negative_Thymocyte,_DN4_(Cd8-,_Cd4-),_some_undergoing_VDJ_recombination_\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JARID2 RAP1A RAP1B PRKCQ BAIAP2	3.36e-05	190	86	5	8f5e71a0861ee4e8f3ce45e8a7f18fb9d6036a3c
ToppCell	facs-Lung-3m-Epithelial-alveolar_epithelial-type_II_pneumocyte-type_2_alveolar_epithelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARFGEF3 SLC26A9 ZNF385B RAB27B TFRC	3.45e-05	191	86	5	f98fc372e579ce69409afbbe0f83c03c7ea62632
ToppCell	facs-Lung-nan-3m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 SLC26A9 ZNF385B RAB27B TFRC	3.45e-05	191	86	5	c06bbad24e4897b2c3b5015e4de02411ebf75367
ToppCell	facs-Lung-3m-Epithelial-alveolar_epithelial-type_II_pneumocyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARFGEF3 SLC26A9 ZNF385B RAB27B TFRC	3.45e-05	191	86	5	210589095a3f5d5117174caf6ec110b502f27030
ToppCell	10x3'2.3-week_17-19-Hematopoietic-MK-early_MK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	KALRN GUCY1B1 PRKCQ ADCY6 RAB27B	3.45e-05	191	86	5	3839bf57419d3ec3d4464277bb33301d2b7d701f
ToppCell	Control-Lymphoid-ILC_A\|Control / Disease state, Lineage and Cell class	DENND4A IRAG2 PRKCQ PLCG2 CNOT2	3.45e-05	191	86	5	1ca73582dc3d28322b5ee841010067589d848acc
ToppCell	facs-Lung-nan-3m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 SLC26A9 ZNF385B RAB27B TFRC	3.45e-05	191	86	5	5f43f98cfe7a08d61ed55f34808fabfe47f1ac2e
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARFGEF3 ESRP1 ZNF385B USP54 TTC6	3.45e-05	191	86	5	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	facs-Lung-EPCAM-3m-Epithelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 SLC26A9 ZNF385B RAB27B TFRC	3.45e-05	191	86	5	629007189034ee8451411428f1c6cc57daee2d91
ToppCell	facs-Lung-3m-Epithelial-alveolar_epithelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARFGEF3 SLC26A9 ZNF385B RAB27B TFRC	3.54e-05	192	86	5	4a46f7980ec145be5b4bf8b98265e3e0f2ea4c63
ToppCell	Epithelial\|World / Lineage, Cell type, age group and donor	ARFGEF3 ESRP1 ZNF385B USP54 TTC6	3.54e-05	192	86	5	499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCell	COPD-Epithelial\|COPD / Disease state, Lineage and Cell class	ARFGEF3 ESRP1 ZNF385B USP54 HYDIN	3.54e-05	192	86	5	0644fad5df18f0021f6f49cca996d8cf47f972ff
ToppCell	10x5'v1-week_14-16-Hematopoietic-MK-MK\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	RAP1B KALRN GUCY1B1 ADCY6 RAB27B	3.54e-05	192	86	5	b877d14be9d04ab0010e340909e3a23de92613db
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ARFGEF3 ESRP1 ZNF385B RAB27B TTC6	3.54e-05	192	86	5	c15841f35e24d6ef6ce2a9a6dc62e66efdc3d9d5
ToppCell	facs-Skin-Anagen-3m-Epithelial-basal_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A2 SERPINB2 NDFIP2 U2AF2 RGS12	3.54e-05	192	86	5	ec1fd2fb6e71f87189d66261909a84e2be63cacb
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	ARFGEF3 ESRP1 ZNF385B USP54 TTC6	3.54e-05	192	86	5	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	Epithelial-club_cell\|World / Lineage, Cell type, age group and donor	ARFGEF3 ESRP1 USP54 RAB27B TTC6	3.62e-05	193	86	5	2bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCell	facs-Lung-24m-Epithelial-alveolar_epithelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARFGEF3 SLC26A9 ZNF385B RAB27B TFRC	3.62e-05	193	86	5	4a1b4a2faf741ffba5c84218af4df6a8b2a9f4de
ToppCell	facs-Lung-24m-Epithelial-alveolar_epithelial-type_II_pneumocyte\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARFGEF3 SLC26A9 ZNF385B RAB27B TFRC	3.62e-05	193	86	5	68adc680deb2f1a29d3cca19c13b9f6271dd4d60
ToppCell	facs-Lung-24m-Epithelial-alveolar_epithelial-type_II_pneumocyte-type_2_alveolar_epithelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARFGEF3 SLC26A9 ZNF385B RAB27B TFRC	3.62e-05	193	86	5	819e6ee2ffa3e31bf9a2d57c99d9e3eac7072765
ToppCell	PCW_05-06-Epithelial-Epithelial_airway\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ARFGEF3 ESRP1 ZNF385B RAB27B TTC6	3.62e-05	193	86	5	af6ec2c2ba92aef3e41531c3c7215b3300437bd9
ToppCell	Fetal_29-31_weeks-Epithelial\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ARFGEF3 ESRP1 ZNF385B USP54 TTC6	3.62e-05	193	86	5	a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCell	10x3'2.3-week_12-13-Hematopoietic-MK-MK\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	RAP1B KALRN GUCY1B1 ADCY6 RAB27B	3.62e-05	193	86	5	3d4411b3c1cb160dec5db29f0c126d8827dfe185
ToppCell	HSPCs-Mk_prog.\|HSPCs / Lineage and Cell class	RAP1B KALRN GUCY1B1 PRKCQ RAB27B	3.71e-05	194	86	5	5c05d508f5c29e6efe87506bf59e3b0fe5922f65
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ARFGEF3 ESRP1 ZNF385B RAB27B TTC6	3.71e-05	194	86	5	b19e16a76d7342ff9a665d19c9151652916f17d4
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FMNL3 RELN KALRN SH2D3C ETS2	3.71e-05	194	86	5	b490fffc94f005dff9a34ce34d80ca776e3a1387
ToppCell	10x3'2.3-week_14-16-Hematopoietic-MK\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	RAP1B KALRN GUCY1B1 ADCY6 RAB27B	3.71e-05	194	86	5	216cba1a04b1a24b080322bc950e7fa2dade5ff1
ToppCell	Control-Myeloid-ncMonocyte\|Control / Disease state, Lineage and Cell class	BLM JARID2 PLXNC1 SH2D3C DNMBP	3.81e-05	195	86	5	fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCell	10x3'2.3-week_14-16-Hematopoietic-MK-MK\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	RAP1B KALRN GUCY1B1 ADCY6 RAB27B	3.90e-05	196	86	5	66ba31b74953726e9c314f6d8fe3f75d3762e23a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FMNL3 RELN KALRN SH2D3C GARRE1	3.90e-05	196	86	5	145fcf73deba9638b391a1af6c39fa205dc9829f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FMNL3 KALRN SH2D3C ETS2 GARRE1	4.00e-05	197	86	5	cd509e49bbdbf991cc5913960ff3ef275ad40628
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FMNL3 KALRN SH2D3C ETS2 GARRE1	4.00e-05	197	86	5	412cb5f37df57121ddd1492021445479c7cbccbf
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ZNF385B PRKCQ USP54 BAIAP2 TTC6	4.09e-05	198	86	5	285f729140b1df029c24f6ca1d2438470ac51794
Disease	Kabuki make-up syndrome	RAP1A RAP1B	4.45e-05	4	81	2	C0796004
Disease	Gilles de la Tourette syndrome (is_implicated_in)	HCN4 BAIAP2	1.11e-04	6	81	2	DOID:11119 (is_implicated_in)
Disease	glycylvaline measurement	PRKCQ NDFIP1	2.06e-04	8	81	2	EFO_0021129
Disease	pulse pressure measurement	FMNL3 ZFHX4 CELF1 PLXNC1 UBR3 ZNF385B NME7 NFAT5 NNT GARRE1 HYDIN ITIH1	4.02e-04	1392	81	12	EFO_0005763
Disease	transferrin receptor protein 1 measurement	NDFIP1 TFRC	6.63e-04	14	81	2	EFO_0802142
Disease	amyotrophic lateral sclerosis, age at onset	ANKS1B CNOT2	7.64e-04	15	81	2	EFO_0004847, MONDO_0004976
Disease	hydrocephalus (implicated_via_orthology)	NME7 HYDIN	1.23e-03	19	81	2	DOID:10908 (implicated_via_orthology)
Disease	body fat percentage	RELN CELF1 ANKS1B BAIAP2 NFAT5 TFRC	2.26e-03	488	81	6	EFO_0007800

Protein segments in the cluster

Peptide	Gene	Start	Entry
RNFRAVFMAVVMGQG	ADCK2	506	Q7Z695
LMGIVSNALMGIFNF	ABCA10	896	Q8WWZ4
RMAGQMLLQTFFNID	CASP4	66	P49662
HSFNNFQMKIGLNMG	ADCY6	1076	O43306
DLLQMFMPFGNVVSA	CELF1	416	Q92879
NIDFEGLFGNMQMVI	DNMBP	821	Q6XZF7
EEMNFVLMGGTLNRN	ESRP1	526	Q6NXG1
NRNLSGGVLMGFMLN	DENND4A	1031	Q7Z401
GGVLMGFMLNRINQE	DENND4A	1036	Q7Z401
DAMGFLLMFDLTSQQ	RAB27B	91	O00194
AMRDLYMKNGQGFAL	RAP1A	66	P62834
AMRDLYMKNGQGFAL	RAP1B	66	P61224
LMANGFDNVQFMGSN	ANKS1B	831	Q7Z6G8
MGMEGLLQNSTNFVL	OR2T2	1	Q6IF00
FRNFSFMNPGMERLI	PRKCQ	691	Q04759
GMFFAAMLQINSSLE	LRRC34	196	Q8IZ02
FNFLEVMSMENNGRA	ITIH1	441	P19827
GFMGINGDLNTLMEN	MTMR8	571	Q96EF0
LGGFNTNNMNMSRAS	LIPM	276	Q5VYY2
VNNRLFDMSAFMAGP	DAG1	231	Q14118
VLQSMNAFFQGLMLL	ECPAS	1736	Q5VYK3
RFGFAMAAMGDLSQD	ITGAE	576	P38570
ISGGQNITMMGRNFD	PLXNC1	766	O60486
MLRVFLFNAMGISPN	OR51A7	81	Q8NH64
RFGMNGQMLCNLGKE	ETS2	131	P15036
CNDMMNLGRLQGFEG	KALRN	2101	O60229
QAMRNFFLMEGGDTM	TUBGCP5	721	Q96RT8
LNAGEILQMFGKMFF	GUCY1B1	61	Q02153
MQMNHALFSLNGRTG	PLCG2	1021	P16885
MGMEGLLQNSTNFVL	OR2T35	1	Q8NGX2
FTFLHLGSGDNMQVM	OC90	291	Q02509
FQQGNEMMSLQSGNF	NFAT5	1046	O94916
AGFMQRQFGAMLQPG	HCN4	211	Q9Y3Q4
NNLFFNEDGLRMLMT	RELN	2201	P78509
RVGNDGIFMLAFFMA	NDFIP2	226	Q9NV92
RIGNDGIFMLTFFMA	NDFIP1	111	Q9BT67
GAVQMGLVNMFKGFQ	HYDIN	11	Q4G0P3
SGRFTMNMLVDIFLG	BLM	1106	P54132
RMAGMAFLGNFQDNL	FMNL3	726	Q8IVF7
GFDGNSSLSFQMLMN	ARFGEF3	716	Q5TH69
MQEVIDFLSGFNMGQ	GARRE1	646	O15063
QGVAAAKQMGLFMEF	CC2D1B	16	Q5T0F9
LMMFFRHSNLGQGTN	HAUS3	176	Q68CZ6
EFRLMMTFSGLNRGF	DND1	86	Q8IYX4
AGMVAGMENNDRFSR	IRAG2	386	Q12912
RRSMVSPNFGFMGQL	DUSP5	296	Q16690
GFLNGRACVMMQGRF	PNP	71	P00491
IRDAGFEISAMQMFN	NME7	261	Q9Y5B8
ACFFRLINEMGGMQQ	JARID2	656	Q92833
SMGMEDAFNKGRANF	SERPINB2	326	P05120
IAGGFLVTQRMLDMF	NNT	571	Q13423
FSNDIQQMMGFRPGL	SLC6A2	501	P23975
GIFLDMGMQNVSFFD	RFPL1	246	O75677
EMFQSAGIRMINNRG	TRNT1	91	Q96Q11
ALMGMFNSIFDGRVV	TMCO1	151	Q9UM00
AIIQMGLGFMQFGFV	SLC26A9	181	Q7LBE3
MDGSFSFKLLNQLGM	LIPI	351	Q6XZB0
AGQMLLVAFDGMFAQ	SMG1	2956	Q96Q15
SFGLSVFNLMNAIMG	SLC38A6	46	Q8IZM9
NNFQVMSMVSGFGPL	SLC12A1	481	Q13621
MSQEMFVGIVGNQFK	SHCBP1	646	Q8NEM2
MMDQARSAFSNLFGG	TFRC	1	P02786
MEQFNPSLRNFIAMG	BAIAP2	21	Q9UQB8
FTVNSMSGFGMNRNQ	CNOT2	186	Q9NZN8
LQISMGQMLQDFGKF	TRPC1	526	P48995
GQMLQDFGKFLGMFL	TRPC1	531	P48995
AMRDLYMKNGQGFAL	nan	66	A6NIZ1
SGLDGNFNSIRMDMF	ZFHX4	3551	Q86UP3
QSARMQRSFMLQQLG	ZBTB5	136	O15062
RAVVCLQMGNNFAAM	TTC6	321	Q86TZ1
MQSGGIFNMIFENPS	RGS12	141	O14924
NRGDFFMTLRNQPMA	VPS16	586	Q9H269
NGMPMDIVNTSGRFF	NPTN	276	Q9Y639
MGFEFNIMVVGQSGL	SEPTIN12	46	Q8IYM1
VGIFLDMGMQNVSFF	RFPL2	306	O75678
GIFLDMGMQNVSFFD	RFPL3	246	O75679
MNMANFLRGFEEKGI	ZNF385B	1	Q569K4
TMFAEMEIIGQFNLG	PMS2	671	P54278
AAQRLLDGMNFMAQS	ZFYVE1	556	Q9HBF4
SALTILMLNGAMFFN	TMEM262	86	E9PQX1
LMLNGAMFFNRLSLE	TMEM262	91	E9PQX1
GTGMAFGLQMFIQRK	TMEM141	41	Q96I45
MNFVSFFQGMNLNKR	UBR3	541	Q6ZT12
MDFFNAQMRLGGLTQ	U2AF2	166	P26368
LAAELRGTMGNMFSF	SH2D3C	671	Q8N5H7
LGLGSANFMELQQQM	UBQLN4	171	Q9NRR5
AQAMQFGQPLVFDMA	TRMT10C	196	Q7L0Y3
RLNQSQEIMRMFFNG	ATP6V0A2	436	Q9Y487
FQRMQGVSMRDSTGF	USP54	1136	Q70EL1
GMLRGMSRLQFLFVQ	ELFN2	121	Q5R3F8