Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmalic enzyme activity

MDH1 ME1 ME3

7.03e-0741133GO:0004470
GeneOntologyMolecularFunctionmalate dehydrogenase activity

MDH1 ME1 ME3

9.68e-0681133GO:0016615
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-6 ERVK-7 ERVK-19 ERVK-25

5.56e-05371134GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-6 ERVK-7 ERVK-19 ERVK-25

6.19e-05381134GO:0070001
GeneOntologyMolecularFunctionplus-end directed microfilament motor activity

MYO10 MYO19

9.49e-0531132GO:0060002
GeneOntologyMolecularFunctionmalate dehydrogenase (decarboxylating) (NADP+) activity

ME1 ME3

9.49e-0531132GO:0004473
GeneOntologyMolecularFunctionoxaloacetate decarboxylase activity

ME1 ME3

1.89e-0441132GO:0008948
GeneOntologyMolecularFunctionNAD binding

MDH1 ME1 SIRT4 ME3

7.84e-04731134GO:0051287
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

ERVK-6 SMG1 DDR2 OBSCN DGKD ERVK-7 SIRT4 ITPKB DSTYK PRKAG1 TNKS POLD3 WNK3 ALPK2

8.37e-0493811314GO:0016772
GeneOntologyMolecularFunctionRNA polymerase I general transcription initiation factor activity

RRN3 RRN3P1

1.11e-0391132GO:0001181
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-6 ERVK-7 POLD3

1.29e-03381133GO:0034061
GeneOntologyBiologicalProcessmalate metabolic process

MDH1 ME1 ME3

1.31e-0591133GO:0006108
MousePhenoabnormal double-strand DNA break repair

SETX BRCA2 MDC1 SPATA22 POLD3 MYBL1

4.35e-0670866MP:0010948
DomainCoatomer_g_Cpla

COPG1 COPG2

3.25e-0521072IPR032154
Domain-

COPG1 COPG2

3.25e-05210722.60.40.1480
DomainCOP-gamma_platf

COPG1 COPG2

3.25e-0521072PF08752
DomainCoatomer_g_Cpla

COPG1 COPG2

3.25e-0521072PF16381
DomainCoatomer_gsu_app_Ig-like-sub

COPG1 COPG2

3.25e-0521072IPR013040
DomainCoatomer_gsu

COPG1 COPG2

3.25e-0521072IPR017106
DomainMalic_OxRdtase

ME1 ME3

9.72e-0531072IPR001891
DomainMalic_NAD-bd

ME1 ME3

9.72e-0531072IPR012302
DomainMalic_N_dom

ME1 ME3

9.72e-0531072IPR012301
DomainMALIC_ENZYMES

ME1 ME3

9.72e-0531072PS00331
DomainMalic_M

ME1 ME3

9.72e-0531072PF03949
DomainMalic_M

ME1 ME3

9.72e-0531072SM00919
Domainmalic

ME1 ME3

9.72e-0531072PF00390
Domain-

ME1 ME3

9.72e-05310723.40.50.10380
Domainmalic

ME1 ME3

9.72e-0531072SM01274
DomainMalic_enzyme_CS

ME1 ME3

9.72e-0531072IPR015884
DomainARM-like

SMG1 SETX COPG1 RTTN COPG2 ARMC9 TTI1 HECTD1

1.63e-042701078IPR011989
DomainClathrin_a/coatomer_app_sub_C

COPG1 COPG2

1.94e-0441072IPR015873
Domain-

COPG1 COPG2

1.94e-04410723.30.310.30
DomainARM-type_fold

SMG1 COPG1 NOC2L RTTN COPG2 ARMC9 TTI1 HECTD1

7.44e-043391078IPR016024
DomainCoatomer/calthrin_app_sub_C

COPG1 COPG2

8.90e-0481072IPR009028
DomainIQ

MYO10 MYO19 OBSCN SCN7A

1.21e-03811074SM00015
Domain-

COPG1 RTTN COPG2 ARMC9 TTI1 HECTD1

1.76e-0322210761.25.10.10
DomainIQ_motif_EF-hand-BS

MYO10 MYO19 OBSCN SCN7A

1.78e-03901074IPR000048
DomainCoatomer/clathrin_app_Ig-like

COPG1 COPG2

2.07e-03121072IPR013041
DomainClathrin/coatomer_adapt-like_N

COPG1 COPG2

3.25e-03151072IPR002553
DomainAdaptin_N

COPG1 COPG2

3.25e-03151072PF01602
DomainA/G_cyclase_CS

ADCY5 GUCY1A1

4.18e-03171072IPR018297
DomainLH2

PKD1L3 ALOX5

4.69e-03181072SM00308
Domain-

ADCY5 GUCY1A1

4.69e-031810723.30.70.1230
DomainNucleotide_cyclase

ADCY5 GUCY1A1

4.69e-03181072IPR029787
DomainGuanylate_cyc

ADCY5 GUCY1A1

5.22e-03191072PF00211
DomainGUANYLATE_CYCLASE_2

ADCY5 GUCY1A1

5.22e-03191072PS50125
DomainA/G_cyclase

ADCY5 GUCY1A1

5.22e-03191072IPR001054
DomainGUANYLATE_CYCLASE_1

ADCY5 GUCY1A1

5.22e-03191072PS00452
DomainCYCc

ADCY5 GUCY1A1

5.22e-03191072SM00044
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

NRIP1 RAPGEF6 ACACB COPG2 ZNF217 ZNF318 MDH1 YEATS2 GTF3C1 BRCA2 PLEKHA2

1.41e-074181141134709266
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-7 ERVK-19

3.41e-075114312629516
Pubmed

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

RAPGEF6 NOC2L CCDC168 ZNF318 NEDD1 RYR2 FSIP2

1.44e-06168114730631154
Pubmed

An improved smaller biotin ligase for BioID proximity labeling.

CCDC168 ZNF318 RYR2 FSIP2 YEATS2 MDC1

3.38e-06123114626912792
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

RAPGEF6 SETX GLCCI1 ITPKB FSIP2 CASKIN2 DSTYK PLEKHA2 DOCK6 HECTD1 SH3RF3 FOXK1 WNK3

5.21e-068611141336931259
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

SECISBP2L RAPGEF6 COPG1 RBM33 NOC2L MYO10 COPG2 FCHO2 NEDD1 GLCCI1 TNKS POLD3 DOCK6 FOXK1

7.99e-0610381141426673895
Pubmed

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

ERVK-6 ERVK-19

1.07e-05211429060628
Pubmed

Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.

ERVK-6 ERVK-19

1.07e-05211429460924
Pubmed

Adaptive and Constitutive Activations of Malic Enzymes Confer Liver Cancer Multilayered Protection Against Reactive Oxygen Species.

ME1 ME3

1.07e-052114233619771
Pubmed

Functional roles of the tetramer organization of malic enzyme.

ME1 ME3

1.07e-052114219416979
Pubmed

Unpackaging the genetics of mammalian fertility: strategies to identify the "reproductive genome".

SETX SPATA22 MYBL1

1.86e-0516114329878059
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

NRIP1 SETX RBM33 ZNF217 ZNF318 YEATS2 BRCA2 BANP DDX20 FOXK1

2.49e-055881141038580884
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

NRIP1 OBSCN NEDD1 ZNF595 TASOR2 ITPKB YEATS2 GTF3C1 GUCY1A1 BANP SFXN3 PRKAG1 PLEKHA2 DOCK6 HECTD1 SH3RF3

2.90e-0514891141628611215
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

MAGEB2 RBM33 NEDD1 YEATS2 MDC1 BANP DDX20 CEP295 PRR14L POLD3 HECTD1

3.05e-057331141134672954
Pubmed

Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.

ERVK-6 ERVK-19

3.19e-053114210516026
Pubmed

Changes in protein expression due to deleterious mutations in the FA/BRCA pathway.

BRCA2 MDC1

3.19e-053114217977515
Pubmed

Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus.

COPG1 COPG2

3.19e-053114211893085
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

NRIP1 SP2 ZNF217 YEATS2 PRKAG1 TNKS DDX20 FOXK1

5.25e-05398114835016035
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-6 ERVK-7

6.36e-054114210469592
Pubmed

Mitochondrial malate dehydrogenase and malic enzyme: Mendelian inherited electrophoretic variants in the mouse.

MDH1 ME1

6.36e-05411425496232
Pubmed

Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.

ERVK-6 ERVK-19

6.36e-05411427983737
Pubmed

5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.

SMG1 COPG2 TTI1

9.47e-0527114323027611
Pubmed

Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization.

DENND2A FCHO2 GLCCI1 BMP4

1.06e-0474114415031102
Pubmed

Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.

ERVK-6 ERVK-7

1.06e-045114211401426
Pubmed

MDC1 and RNF8 function in a pathway that directs BRCA1-dependent localization of PALB2 required for homologous recombination.

BRCA2 MDC1

1.06e-045114223038782
Pubmed

A hydride transfer complex reprograms NAD metabolism and bypasses senescence.

MDH1 ME1

1.06e-045114234547241
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

SP2 SETX ZNF318 NEDD1 YEATS2 BRCA2 POLD3 FOXK1

1.12e-04444114834795231
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

MYO10 ZNF217 YEATS2 DSTYK PLEKHA2 FOXK1 ALPK2

1.17e-04332114737433992
Pubmed

Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs.

MDC1 TNKS

1.58e-046114226845027
Pubmed

Identification and characterization of novel isoforms of COP I subunits.

COPG1 COPG2

1.58e-046114211056392
Pubmed

Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

ERVK-6 ERVK-19

1.58e-046114215063128
Pubmed

Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum.

COPG1 COPG2

1.58e-046114211884415
Pubmed

Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models.

BRCA2 SPATA22 MYBL1

1.59e-0432114327739607
Pubmed

Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo.

ALX3 UNCX BMP4

1.91e-0434114312086465
Pubmed

Elongator and codon bias regulate protein levels in mammalian peripheral neurons.

SETX BRCA2

2.21e-047114229497044
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

SMG1 NRIP1 ACACB RYR2 ITPKB YEATS2 UNC5C PLCB1 CEP295

2.61e-04638114931182584
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-6 ERVK-7 ERVK-19 ERVK-25

2.66e-0494114421542922
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

SMG1 ACACB UNCX NOC2L DPPA2 CAGE1 ZNF318 RYR2 TASOR2 OR10G4 GTF3C1 UNC5C CEP295 G6PC2

2.71e-0414421141435575683
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

RAPGEF6 KIF26A MYO10 RTTN OBSCN BMP4 BANP MAPKBP1 DOCK6 HECTD1 ALOX5 FOXK1

2.81e-0411051141235748872
Pubmed

In vivo assembly of coatomer, the COP-I coat precursor.

COPG1 COPG2

2.94e-04811428940050
Pubmed

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.

SMG1 TTI1

2.94e-048114220810650
Pubmed

Novel isotypic gamma/zeta subunits reveal three coatomer complexes in mammals.

COPG1 COPG2

2.94e-048114214729954
Pubmed

RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development.

UNCX BMP4

2.94e-048114217473173
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

SECISBP2L SMG1 RAPGEF6 SETX MYO19 GTF3C1 CASKIN2 SUPV3L1 DSTYK

2.99e-04650114938777146
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

COPG1 NOC2L COPG2 ZNF318 TASOR2 GTF3C1 MDC1 DDX20 HECTD1

3.09e-04653114922586326
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

ACACB COPG1 DPPA2 YEATS2 MDC1 TTI1 DDX20

3.41e-04396114726687479
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SMG1 DENND2A SETX KIF26A CASKIN2 MDC1 PLCB1 DOCK6

3.65e-04529114814621295
Pubmed

The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells.

BRCA2 SPATA22

3.78e-049114232345962
Pubmed

A single binding site for dilysine retrieval motifs and p23 within the gamma subunit of coatomer.

COPG1 COPG2

3.78e-04911429751720
Pubmed

COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP.

COPG1 COPG2

3.78e-049114210921873
Pubmed

Comparative mapping in the beige-satin region of mouse chromosome 13.

RYR2 ITPKB

4.71e-041011429027500
Pubmed

SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase.

ACACB PRKAG1

4.71e-0410114219720090
Pubmed

Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.

ERVK-6 ERVK-19

4.71e-0410114212970426
Pubmed

Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network.

BRCA2 SFXN3 DDX20 FOXK1

5.01e-04111114432683582
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

SETX COPG1 NOC2L MYO19 DGKD GTF3C1 SUPV3L1 MDC1 A2ML1 SFXN3 DDX20 PRR14L POLD3

5.01e-0413531141329467282
Pubmed

Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor.

NRIP1 COPG1 RBM33 ZNF217

5.35e-04113114423403292
Pubmed

Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.

SMG1 TTI1

5.75e-0411114220427287
Pubmed

Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis.

BMP4 UNC5C

5.75e-0411114215186747
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

SMG1 NOC2L ZNF318 GTF3C1 NUP37 MDC1 HECTD1

6.37e-04440114734244565
Pubmed

Discovery and refinement of loci associated with lipid levels.

CUBN BRCA2 A2ML1 DOCK6 ALOX5

6.73e-04211114524097068
Pubmed

Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.

COPG1 COPG2 GTF3C1 DDX20 ZNF121

6.73e-04211114517314511
Pubmed

HDAC1/NFκB pathway is involved in curcumin inhibiting of Tat-mediated long terminal repeat transactivation.

ACACB PRKAG1

6.88e-0412114221344388
Pubmed

Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1).

COPG1 COPG2

6.88e-0412114210788617
Pubmed

The Hectd1 ubiquitin ligase is required for development of the head mesenchyme and neural tube closure.

BMP4 HECTD1

6.88e-0412114217442300
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-6 ERVK-19

6.88e-0412114214557543
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

SETX COPG1 MYO19 ADGRB1 OBSCN AFAP1L2 GTF3C1 CEP295 ALOX5

7.30e-04736114929676528
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

SETX GTF3C1 BRCA2 MDC1 SFXN3 CLN6 DDX20

7.55e-04453114729656893
Pubmed

Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.

SETX ZNF217 YEATS2 GTF3C1

7.82e-04125114432891193
Pubmed

The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.

FCHO2 YEATS2 PLEKHA2 DOCK6

7.82e-04125114429467281
Pubmed

The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.

BRCA2 MDC1

8.11e-0413114229499138
Pubmed

A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination.

BRCA2 SPATA22

8.11e-0413114230760716
Pubmed

Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development.

ALX3 BMP4

8.11e-0413114230905259
Pubmed

HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.

TNKS HECTD1

8.11e-0413114223277359
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

NOC2L SYBU RYR2 GTF3C1 R3HDM4 DDX20 WNK3

8.47e-04462114731138677
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

COPG1 COPG2 ZNF318 NEDD1 STC2 TTI1 ATP13A3 DOCK6 HECTD1

8.65e-04754114933060197
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

RAPGEF6 SETX OBSCN COPG2 ZNF318 CUBN FCHO2 ZNF595 UNC5C SFXN3 CEP295

8.87e-0410841141111544199
Pubmed

Expression profiles of active genes in human and mouse livers.

MDH1 A2ML1

9.45e-041411428863742
Pubmed

PITX1 promotes chondrogenesis and myogenesis in mouse hindlimbs through conserved regulatory targets.

ALX3 BMP4

9.45e-0414114229273440
Pubmed

Condensin I and II Complexes License Full Estrogen Receptor α-Dependent Enhancer Activation.

NRIP1 HECTD1

9.45e-0414114226166704
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

FCHO2 MDH1 NEDD1 A2ML1 PLCB1 TNKS DDX20

9.95e-04475114731040226
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

KIF26A SYBU SIRT4 BANP CEP295

1.05e-03233114537704626
Pubmed

ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.

ACACB ZNF318 ME1 TASOR2 YEATS2 BANP DDX20 POLD3

1.07e-03624114833729478
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

SETX RBM33 COPG2 ZNF318 TASOR2 YEATS2 BRCA2 MDC1 KLK9 SPATA22

1.20e-039541141036373674
Pubmed

Tbx18 regulates the development of the ureteral mesenchyme.

UNCX BMP4

1.24e-0316114216511601
Pubmed

Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.

SUPV3L1 G6PC2

1.24e-0316114223903356
Pubmed

Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.

BRCA2 MDC1

1.24e-0316114227760317
Pubmed

Loss of function of mouse Pax-Interacting Protein 1-associated glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression and defects in chorion and amnion development.

UNCX BMP4

1.24e-0316114224633704
Pubmed

Smad4 is required to regulate the fate of cranial neural crest cells.

ALX3 BMP4

1.24e-0316114217964566
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

NRIP1 ACACB RBM33 OBSCN ME1 GTF3C1 SH3RF3

1.29e-03497114736774506
Pubmed

The interactome of the prostate-specific protein Anoctamin 7.

COPG1 COPG2 DDX20

1.29e-0365114332176628
Pubmed

Esrrb function is required for proper primordial germ cell development in presomite stage mouse embryos.

DPPA2 BMP4

1.40e-0317114231315026
Pubmed

Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under the control of Notch signaling.

UNCX GLCCI1

1.40e-0317114215511637
Pubmed

Specific inactivation of Twist1 in the mandibular arch neural crest cells affects the development of the ramus and reveals interactions with hand2.

ALX3 BMP4

1.40e-0317114222411303
Pubmed

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.

NRIP1 SETX OBSCN BRCA2

1.50e-03149114425184681
Pubmed

A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1.

BRCA2 SPATA22

1.57e-0318114232845237
Pubmed

Winged-helix, Hedgehog and Bmp genes are differentially expressed in distinct cell layers of the murine yolk sac.

BMP4 FOXK1

1.57e-031811429152011
Pubmed

Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules.

ALX3 BMP4

1.57e-0318114223201021
Pubmed

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.

ACACB PRKAG1

1.57e-0318114216054041
Pubmed

Gestational folate deficiency alters embryonic gene expression and cell function.

CUBN BMP4

1.57e-0318114233302058
Pubmed

Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.

GTF3C1 GCAT NUP37 SUPV3L1 SFXN3 PRKAG1 HECTD1

1.58e-03515114731617661
CoexpressionAtlasdev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000

LYPD4 SMG1 SETX ENPP3 DPPA2 COPG2 DGKD ZNF217 ZNF318 CUBN TASOR2 BRCA2 MDC1 CEP295 POLD3 WNK3 MYBL1

9.35e-0782010917gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
CoexpressionAtlasdev gonad_e11.5_M_SupCellPrec_Sry_k-means-cluster#3_top-relative-expression-ranked_200

ME1 STC2 WNK3 MYBL1

3.41e-05361094gudmap_dev gonad_e11.5_M_SupCellPrec_Sry_k3_200
ToppCellAdult-Mesenchymal-pericyte_cell-D122|Adult / Lineage, Cell type, age group and donor

DENND2A MYO10 OBSCN ADCY5 RYR2 AFAP1L2 UNC5C PLCB1 DOCK6 SH3RF3

3.19e-1118311010fc31a43a637423cb3bb9aa184a3a889a0b9aaea6
ToppCellAdult-Mesenchymal-pericyte_cell|Adult / Lineage, Cell type, age group and donor

DENND2A DDR2 OBSCN ADCY5 RYR2 AFAP1L2 UNC5C PLCB1 DOCK6 SH3RF3

3.95e-111871101062759efb660179402fb574ce5701c89a2e17bcfe
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DENND2A MYO10 DDR2 OBSCN ADCY5 RYR2 AFAP1L2 UNC5C PLCB1 DOCK6

4.62e-11190110104eb92aef1ee868f4537483d19014d947b7684612
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DENND2A MYO10 DDR2 OBSCN ADCY5 RYR2 AFAP1L2 UNC5C PLCB1 DOCK6

4.62e-11190110107be4341e2909101d756f14031c21e705eb45e69a
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

DENND2A MYO10 OBSCN ADCY5 RYR2 AFAP1L2 UNC5C PLCB1 DOCK6

6.38e-101781109185b44700f06ec58b3c09c80520502166c965fd6
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

DENND2A MYO10 DDR2 ADCY5 RYR2 AFAP1L2 UNC5C SCN7A PLCB1

7.40e-101811109451b87ac95154bb80018b8dd245b4a6389d81411
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DENND2A MYO10 DDR2 OBSCN ADCY5 RYR2 UNC5C PLCB1 DOCK6

9.87e-10187110986250acf088ec0c4800a0dfa031b0d4f7e52c342
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

DENND2A MYO10 OBSCN ADCY5 RYR2 AFAP1L2 UNC5C PLCB1 DOCK6

1.03e-091881109ee151792c7ac9afe820f1a281c6dab383799f358
ToppCellMesenchymal-pericyte_cell|World / Lineage, Cell type, age group and donor

DENND2A MYO10 OBSCN ADCY5 RYR2 AFAP1L2 UNC5C PLCB1 DOCK6

1.08e-091891109d7ed96add29f219183c802895fbff519b627f635
ToppCellParenchymal-NucSeq-Stromal-Pericyte-Muscle_pericyte_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DENND2A DDR2 OBSCN ADCY5 RYR2 AFAP1L2 UNC5C PLCB1 PLEKHA2

1.56e-091971109f66945f9007d59d4208849c7fd727f8519713fbc
ToppCellParenchymal-NucSeq-Stromal-Pericyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DENND2A DDR2 OBSCN ADCY5 RYR2 AFAP1L2 UNC5C PLCB1 PLEKHA2

1.56e-09197110941dd312f46a2b983c8d864adeb6970c0ca4a8048
ToppCellAdult-Mesenchymal-pericyte_cell-D231|Adult / Lineage, Cell type, age group and donor

DENND2A DUSP19 ADCY5 RYR2 AFAP1L2 UNC5C PLCB1 SH3RF3

1.14e-081721108858cee96c1c06160863b4adcd7023c0d678bd50f
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DENND2A MYO10 COPG2 RYR2 AFAP1L2 PLCB1 PLEKHA2 DOCK6

2.01e-081851108a7dba7db79275884b2a93d8a16f2e0c739e71370
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DENND2A MYO10 OBSCN RYR2 AFAP1L2 PLCB1 PLEKHA2 DOCK6

2.19e-081871108a2bf958ea59c359a265bfa437d59315e1920cdd4
ToppCellnucseq-Mesenchymal-Myocytic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DENND2A DDR2 OBSCN ADCY5 RYR2 AFAP1L2 UNC5C PLCB1

2.91e-0819411082d66091097e106c7bee22e5281f50724700bdf8d
ToppCellCOVID-19-lung-Pericytes/_Smooth_Muscle|COVID-19 / Disease (COVID-19 only), tissue and cell type

DENND2A ADCY5 RYR2 AFAP1L2 GUCY1A1 UNC5C PLCB1 SH3RF3

3.15e-081961108754a3613340932563cd8424d775e18b93c3a1aaa
ToppCellBronchial-10x5prime-Stromal-Pericyte|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DENND2A DDR2 ADGRB1 OBSCN ADCY5 RYR2 AFAP1L2 PLCB1

3.68e-082001108362706445edb33b313684efe50b1f44f5f816e67
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte-Pericyte_2|Control_saline / Treatment groups by lineage, cell group, cell type

DENND2A DDR2 DGKD ADCY5 RYR2 AFAP1L2 PLCB1 MDGA1

3.68e-082001108bc8949eb34482aca166c4602ff6ab876cb4c2c3c
ToppCellControl-Fibroblasts-Pericytes|Control / group, cell type (main and fine annotations)

DENND2A DDR2 OBSCN RYR2 AFAP1L2 UNC5C PLCB1

2.32e-071711107080003f698f867935c2bfc55d241d3650f45a0ab
ToppCellAdult-Mesenchymal-pericyte_cell-D175|Adult / Lineage, Cell type, age group and donor

DENND2A DDR2 OBSCN ADCY5 RYR2 UNC5C PLCB1

2.51e-071731107fd6653d6be9ca6ac36798590694efe03cb758c67
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DENND2A ADGRB1 DGKD ADCY5 RYR2 AFAP1L2 PLCB1

3.67e-0718311078a799807fbf24456a9811e0c64068187940a2f71
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DENND2A ADGRB1 ADCY5 RYR2 AFAP1L2 PLCB1 MDGA1

3.81e-071841107327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCellCOVID-19-Fibroblasts-Pericytes|COVID-19 / group, cell type (main and fine annotations)

DENND2A ADCY5 RYR2 AFAP1L2 GUCY1A1 UNC5C PLCB1

3.95e-0718511074905adaeeffd353e089578e5ea614437dbe794e6
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DENND2A MYO10 OBSCN RYR2 UNC5C PLCB1 DOCK6

4.10e-071861107888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DENND2A MYO10 OBSCN RYR2 AFAP1L2 PLCB1 DOCK6

4.90e-0719111071626b23a57429f835fddc052e3c57f63a4e5b8bb
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DENND2A MYO10 OBSCN RYR2 AFAP1L2 PLCB1 DOCK6

4.90e-071911107716dfa7fccbd62b5f574792e68a26dc6c45511dc
ToppCellBronchial-NucSeq-Stromal-Pericyte-Muscle_pericyte_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DENND2A OBSCN ADCY5 RYR2 AFAP1L2 UNC5C PLCB1

6.45e-071991107929f809579368201331d9099d8904b6e3c41797b
ToppCellBronchial-NucSeq-Stromal-Pericyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DENND2A OBSCN ADCY5 RYR2 AFAP1L2 UNC5C PLCB1

6.45e-071991107854628ce91068093c14bd4d45ba38c41469f3549
ToppCellBronchial-10x5prime-Stromal-Pericyte-Muscle_pericyte_pulmonary|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DENND2A DDR2 ADGRB1 OBSCN RYR2 AFAP1L2 PLCB1

6.67e-07200110712326cc6f0af24bacba9493dc79e7c7347db2f41
ToppCellParenchyma_Control_(B.)-Stromal-TX-Smooth_muscle-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

DENND2A MYO10 OBSCN RYR2 AFAP1L2 PLCB1 DOCK6

6.67e-0720011070c648941447c738caf62f2d71e296d6cca492c8b
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Smooth_muscle-1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DENND2A MYO10 OBSCN RYR2 AFAP1L2 PLCB1 DOCK6

6.67e-072001107522a51a284d2992d519c4669e1a48c8ebcc08c80
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Smooth_muscle-1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

DENND2A MYO10 OBSCN RYR2 AFAP1L2 PLCB1 DOCK6

6.67e-07200110794f1fa61aa82eb9f411b2b1cb759476939ab5db7
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D122|Adult / Lineage, Cell type, age group and donor

DENND2A DUSP19 ADCY5 RYR2 UNC5C PLCB1

2.91e-061601106fd14dfeb7021a4b7299371854dc8fc1fd66c8dae
ToppCell356C-Fibroblasts-Fibroblast-G-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SMG1 MYO10 PCDHA6 GLCCI1 RYR2 SCN7A

2.91e-0616011060293b244c063a62819690bf22bbc2681f8d15252
ToppCell356C-Fibroblasts-Fibroblast-G|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SMG1 MYO10 PCDHA6 GLCCI1 RYR2 SCN7A

2.91e-0616011063eaae86fa08f7651021316f8e5811bf48055591e
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D122|Adult / Lineage, Cell type, age group and donor

DUSP19 ADCY5 RYR2 UNC5C A2ML1 PLCB1

3.01e-06161110664891f6f2ee1693c8481e951b9346e2f92d602e3
ToppCelldroplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACACB KIF26A SLC12A8 BCL6B BMP4 CASKIN2

5.91e-061811106136b0c60680068838d184d32aa99d7bea8718dbc
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DENND2A ADGRB1 ADCY5 RYR2 AFAP1L2 PLCB1

6.49e-061841106689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCell356C-Endothelial_cells-Endothelial-E-|356C / Donor, Lineage, Cell class and subclass (all cells)

KIF26A CUBN BCL6B STC2 CASKIN2 WNK3

6.90e-0618611062e024097ee361eeb1d855a4edb8ac8cdad35da06
ToppCell356C-Endothelial_cells-Endothelial-E|356C / Donor, Lineage, Cell class and subclass (all cells)

KIF26A CUBN BCL6B STC2 CASKIN2 WNK3

6.90e-061861106c3449e54454009973818fc1101933c6f0168258c
ToppCellfacs-Heart-LV-18m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF26A MYO10 SYBU ITPKB CASKIN2 PLCB1

7.34e-061881106ed11e26ff4ef3d6314b5f5734062519b9aa285c1
ToppCellfacs-Heart-LV-18m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF26A MYO10 SYBU ITPKB CASKIN2 PLCB1

7.34e-061881106e5a8ca4613ab0bf1584b9e78959adf41d0bf379f
ToppCellfacs-Heart-LV-18m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF26A MYO10 SYBU ITPKB CASKIN2 PLCB1

7.34e-0618811060fc3a6562e6895f6fe7a93397eae842a75c60c93
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DENND2A MYO10 DDR2 RYR2 BMP4 UNC5C

7.57e-0618911062a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DENND2A ADGRB1 RYR2 AFAP1L2 GUCY1A1 PLCB1

7.80e-06190110610125091ad648163777b02e9f0d5e8d7f17d44a5
ToppCellFetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DENND2A ADCY5 RYR2 GUCY1A1 PLCB1 PLD5

7.80e-061901106d6b3a92119b210974a32af3fe9875d60eb02761e
ToppCellControl-Fibroblasts|Control / group, cell type (main and fine annotations)

DENND2A DDR2 RYR2 UNC5C SCN7A SH3RF3

7.80e-0619011063a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCellfacs-Aorta-Heart-18m-Endothelial-aortic_endothelial_cell|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF26A MYO10 ITPKB BCL6B CASKIN2 PLCB1

8.53e-0619311067b7fecd332d3c99b8810bd7e14ab33aab46f2ffd
ToppCellfacs-Aorta-Heart-18m-Endothelial|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF26A MYO10 ITPKB BCL6B CASKIN2 PLCB1

8.53e-0619311067170cbaef0ba1b65cab89c5d4ce525e6c04e4418
ToppCellfacs-Aorta-Heart-18m-Endothelial-nan|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF26A MYO10 ITPKB BCL6B CASKIN2 PLCB1

8.53e-061931106348a89bbf5fe7f7c875300c9ec3cb245c37e1308
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DENND2A MYO10 DDR2 RYR2 UNC5C SCN7A

8.53e-061931106b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCellCOVID-19-Endothelial_cells-Inflamed_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

BCL6B STC2 CASKIN2 PLCB1 DOCK6 SH3RF3

8.53e-061931106979ebefa527f86bebeea5d94e626ee6c1cc7d53b
ToppCellCOVID-19-Fibroblasts-Other_FB|COVID-19 / group, cell type (main and fine annotations)

DENND2A DDR2 RYR2 UNC5C SCN7A SH3RF3

8.53e-061931106e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCellControl-Fibroblasts-Intermediate_pathological_FB|Control / group, cell type (main and fine annotations)

DENND2A DDR2 RYR2 UNC5C SCN7A SH3RF3

8.78e-06194110603a269f75a481ea54aea8e6444605db8d6df493d
ToppCellCOVID-19-lung-Pericytes/_Smooth_Muscle|lung / Disease (COVID-19 only), tissue and cell type

DENND2A ADCY5 RYR2 AFAP1L2 UNC5C PLCB1

8.78e-0619411065e1e0513a54ec4cf0b247ec85c9fbc68dfac1da3
ToppCellCOVID-19-Fibroblasts-Alveolar_FB|COVID-19 / group, cell type (main and fine annotations)

DENND2A MYO10 RYR2 GUCY1A1 UNC5C SCN7A

9.04e-061951106603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCellParenchymal-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DENND2A ADCY5 RYR2 UNC5C PLCB1 SH3RF3

9.86e-061981106bd42c03e384e64f61b02618cf1a5440033bb04b2
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

DENND2A MYO10 DDR2 RYR2 BMP4 UNC5C

1.01e-051991106a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCellBronchial-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DENND2A DDR2 RYR2 UNC5C SCN7A SH3RF3

1.04e-052001106389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DENND2A MYO10 RYR2 UNC5C SCN7A SH3RF3

1.04e-052001106e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte-Pericyte_2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DENND2A DGKD ADCY5 AFAP1L2 PLCB1 MDGA1

1.04e-052001106d2fcd3bd7c3223875f027eeb48ff621192a5f242
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Pericyte|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

DENND2A DGKD ADCY5 RYR2 AFAP1L2 PLCB1

1.04e-0520011064e1e19214aeebbdca004de7faaf4cc9d18498591
ToppCellParenchymal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DENND2A DDR2 RYR2 UNC5C SCN7A SH3RF3

1.04e-052001106cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Pericyte-Pericyte_2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

DENND2A DGKD ADCY5 RYR2 AFAP1L2 PLCB1

1.04e-052001106786f1ae53e60b5ffbf4bfd393d10b802478148b3
ToppCellBronchial-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DENND2A DDR2 RYR2 UNC5C SCN7A SH3RF3

1.04e-052001106cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DENND2A DDR2 RYR2 UNC5C SCN7A SH3RF3

1.04e-052001106311fab076f2ceb258e3970eb21e39344b894042a
ToppCellLPS-antiTNF-Stromal_mesenchymal-Myocytic|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DENND2A ADGRB1 ADCY5 RYR2 AFAP1L2

4.29e-0515611056365b69ede98bc866e996bc52736b00401aacf6f
ToppCellLPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DENND2A ADGRB1 ADCY5 RYR2 AFAP1L2

4.42e-051571105bfec34182f052cf1c0d847ba53ea335d4d1190de
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GUCY1A1 PLD5 MAPKBP1 MDGA1 MYBL1

5.76e-05166110543f84d3cd58e93ce00c241656c4cba27604b4932
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ACACB ZNF318 FCHO2 PKD1L3 BRCA2

5.93e-051671105881f64db8dea3faa7588bf04d87c20924a4e5952
ToppCellMild/Remission-B_naive-4|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SECISBP2L NRIP1 DGKD ZNF318 PLEKHA2

6.27e-051691105c3a6179a64589a370108fea809b157839347759c
ToppCellAdult-Endothelial-endothelial_cell_of_vein-D175|Adult / Lineage, Cell type, age group and donor

BCL6B AFAP1L2 PRSS48 DOCK6 SH3RF3

6.27e-051691105e1f0298236e4a1c59077c14f0dd29a78fac12648
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DDR2 ADGRB1 DGKD ADCY5 RYR2

6.45e-0517011055570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

ADCY5 RYR2 GUCY1A1 UNC5C PLCB1

6.82e-051721105c62cad0f4212d1e9ea1ec3143ad3c4e06aff0ebf
ToppCellAT1-AT2_cells-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

IL31RA VWCE AFAP1L2 PLD5 MDGA1

7.60e-051761105f86832cfeff5b3cfffe4455c1b96a1420d48ba1e
ToppCellCOVID-19_Severe-MAIT|COVID-19_Severe / Disease condition and Cell class

NRIP1 ME1 GTF3C1 PLCB1 MYBL1

7.81e-0517711058eb69041f482b58325e3539f607923f7b1fa5977
ToppCelltumor_Lung-Endothelial_cells-EPCs|tumor_Lung / Location, Cell class and cell subclass

KIF26A ZNF318 SIRT4 STC2 WNK3

7.81e-051771105f8b152c09d56a97e8c0482fb1a3964c05f9dc8c5
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DENND2A ACACB ADCY5 GUCY1A1 PLCB1

8.02e-0517811054df6218b20c2f076c22346d23260964cc0d73e65
ToppCellCOVID-19-kidney-Stressed_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

ITPKB STC2 PLCB1 DOCK6 SH3RF3

8.23e-051791105754f69bac7a1d5137f5141f6193285ccbfe361cb
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYO10 OBSCN ADCY5 UNC5C NPAP1

8.23e-051791105dc6cd46fa652b296ddbc41855f6377946d0a4cdc
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DENND2A DDR2 AFAP1L2 GUCY1A1 DOCK6

8.23e-05179110556db12467b445f2b8ef92af50779eeab10413eb2
ToppCellCOVID-19-kidney-PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

ITPKB STC2 PLCB1 DOCK6 SH3RF3

8.45e-051801105493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCellEndothelial-A-HP_01|World / lung cells shred on cell class, cell subclass, sample id

BCL6B STC2 CASKIN2 DOCK6 SH3RF3

8.45e-0518011054c3376169770ee9f9283daae44c17f35e46bfd19
ToppCellCOVID-19-Heart-Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

DENND2A ADCY5 GUCY1A1 UNC5C SCN7A

8.67e-05181110533cac65ed1ea5e7bd72250495df4f850b143d5aa
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

MYO10 RYR2 UNC5C SCN7A PLD5

8.67e-0518111059ede19228ba5c0668a9c06c915510b95585216ef
ToppCellCOVID-19-Heart-CM_3|Heart / Disease (COVID-19 only), tissue and cell type

OBSCN DGKD RYR2 ATP13A3 ALPK2

8.90e-051821105287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-large_intestine_goblet_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC12A8 SYBU NECTIN1 PLCB1 ATP13A3

9.13e-0518311055a936fb07074cec753bf19e3e3e52499605ea22c
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Goblet_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC12A8 SYBU NECTIN1 PLCB1 ATP13A3

9.13e-05183110507c18ccc45ddc9c22e482bd9ffb87f46ebcfe473
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DDR2 GUCY1A1 UNC5C PLD5 SH3RF3

9.37e-051841105c5436a8e45f471b8d1301abbe9c7879204537f52
ToppCell3'_v3-lymph-node_spleen-Mast-Mast_cells|lymph-node_spleen / Manually curated celltypes from each tissue

MAGEB2 ENPP3 SCN7A ALOX5 WNK3

9.37e-051841105ed266bd2d12f86e8786473e64fbcd58319cd4c2a
ToppCellCOVID-19-kidney-FLT1+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

ITPKB STC2 PLCB1 DOCK6 SH3RF3

9.61e-051851105673308ca0514a4d3629d61fe91e9d8fb31b72166
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO10 SYBU FCHO2 ITPKB DOCK6

9.86e-0518611050ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF26A ADGRB1 ADCY5 GUCY1A1 KLK9

1.01e-041871105ddfc2d1d9fcc3d8e4d3d015576bb17eebf44ada9
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DENND2A DDR2 CUBN SCN7A PLD5

1.01e-041871105d2ffb2f34f07b0dd5d3cb3ee0275f46ebecf4146
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DENND2A OBSCN ADCY5 AFAP1L2 PLCB1

1.04e-041881105ccddc08121caff958a2b6f9e278a018858af6b4d
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KIF26A BCL6B CASKIN2 PLCB1 DOCK6

1.04e-0418811050026c9479b30fb39daa91cfa220a88f9c9e65fe7
ToppCellfacs-Heart-LV-3m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO19 OBSCN ME3 YEATS2 NECTIN1

1.04e-04188110540ce7125fca6f6b6b5cc1637c87d43c29b08f4f1
ToppCellControl-Fibroblasts-Adventitial_FB|Control / group, cell type (main and fine annotations)

DENND2A DDR2 UNC5C SCN7A SH3RF3

1.04e-041881105706a26c372add839d947749f0521a0e1f5c9b0ec
ToppCellfacs-Heart-LV-3m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO19 OBSCN ME3 YEATS2 NECTIN1

1.04e-041881105ba7f7ce034c0f42742bf2461f68f8d343ee593a5
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

DENND2A RYR2 AFAP1L2 SCN7A PLCB1

1.06e-0418911059c2492c38f27e4c699b40680652e4c64911cce52
DiseaseCAKUT (is_implicated_in)

NRIP1 BMP4

3.90e-0531072DOID:0080205 (is_implicated_in)
DiseaseCleft Lip with or without Cleft Palate

BMP4 NECTIN1

1.29e-0451072C0810364
DiseaseUnilateral agenesis of kidney

BMP4 DSTYK

3.60e-0481072C0266294
Diseasetonsillectomy risk measurement

RAPGEF6 SLC12A8 PKD1L3 GLCCI1 GPX6 MDC1

3.80e-042601076EFO_0007924
Diseaseplatelet component distribution width

DENND2A NRIP1 RTTN DUSP19 CUBN ADCY5 BCL6B AFAP1L2 PLCB1 ATP13A3

4.28e-0475510710EFO_0007984
DiseaseCleft palate with cleft lip

BMP4 NECTIN1

4.61e-0491072C0158646
Diseasecervical carcinoma

ACACB DDR2 FSIP2 GPX6 TNKS

5.40e-041821075EFO_0001061
Diseaseplatelet crit

DENND2A NRIP1 KIF26A RTTN SUSD3 DGKD ZNF318 CUBN ADCY5 BANP PLCB1

6.88e-0495210711EFO_0007985
DiseaseIGFBP-1 measurement

MYO10 ZNF217

9.90e-04131072EFO_0005118
Diseasealkaline phosphatase measurement

ACACB NOC2L ENPP3 ZNF318 FCHO2 PKD1L3 ADCY5 ITPKB TNKS PRR14L ALPK2

1.16e-03101510711EFO_0004533
Diseasecleft lip (is_implicated_in)

BMP4 NECTIN1

1.33e-03151072DOID:9296 (is_implicated_in)
DiseasePancreatic carcinoma

BRCA2 ALOX5

2.14e-03191072C0235974
DiseaseParkinson's disease (implicated_via_orthology)

ADCY5 RRN3 ATP13A3 RRN3P1

2.60e-031571074DOID:14330 (implicated_via_orthology)
Diseasesmall cell lung carcinoma

FCHO2 BRCA2 A2ML1

3.11e-03801073EFO_0000702
DiseaseBMI-adjusted fasting blood glucose measurement

ADCY5 G6PC2

3.14e-03231072EFO_0008036
Diseasetriglyceride measurement, low density lipoprotein cholesterol measurement

ZMYND15 ACACB BRCA2 TNKS

3.18e-031661074EFO_0004530, EFO_0004611
DiseaseDiuretic use measurement

NRIP1 ZNF318 GUCY1A1 PLCB1

3.39e-031691074EFO_0009928

Protein segments in the cluster

PeptideGeneStartEntry
TRIPCLLAPSVFKAS

BANP

431

Q8N9N5
FKPLVCISPNASLFD

PRKAG1

126

P54619
LNSSVTVPLQSCIKP

ERVK-19

371

O71037
SALNPSQPPSFLCKT

CAGE1

216

Q8TC20
KTSKAASFPQLPLDC

ALX3

96

O95076
LCDPSAPLAFLQASK

ADGRB1

126

O14514
PLCFLSTLLSQKVPE

ALPK2

11

Q86TB3
FTSKTPSISCVPNLI

ATP13A3

911

Q9H7F0
TSNPTPAVLCFRVKN

FCHO2

586

Q0JRZ9
TLPARLNFPSVQKVC

A2ML1

26

A8K2U0
LNFPSVQKVCLDLSP

A2ML1

31

A8K2U0
CTPVNSATTLKNRPL

AFAP1L2

781

Q8N4X5
VNFIPTGSAFCPVKL

GLCCI1

451

Q86VQ1
SLPQIPCLSSFKIHQ

DDX20

571

Q9UHI6
SCVKLFPSPLQTLSR

ADCY5

811

O95622
VNSVNSSIPKACCVP

BMP4

361

P12644
LPSCLPALASSQVKR

R3HDM4

26

Q96D70
CSATPSAQVKPIVSA

RBM33

726

Q96EV2
NCSLTPHVPFKLVST

PCDHA6

386

Q9UN73
ISCFANVPKDTPLFS

ACACB

1386

O00763
KTVFLRCTVNSNPPA

MDGA1

151

Q8NFP4
PPILKLACADTSANV

OR10G4

181

Q8NGN3
PIIFALSNPTSKAEC

ME1

401

P48163
DCSVALPFPSISKQH

MDC1

61

Q14676
FLAKVNGTTPCAFPT

MAGEB2

291

O15479
KAPASGICFSPVNEL

NEDD1

206

Q8NHV4
FSLAALPAKPENISC

IL31RA

16

Q8NI17
TNAGCTLVALNPFKP

MYO19

66

Q96H55
PILSSAKAQVNPAIC

DDR2

16

Q16832
KASVLAPLFSSCGPQ

ARMC9

781

Q7Z3E5
TTQPVVSPKCLTSAL

KIAA2026

1726

Q5HYC2
NAKNPTSARLPLTFC

FSIP2

2176

Q5CZC0
SKSAPSIPKENFSCL

MDH1

141

P40925
AALSLQLPFCKPQTT

CSNKA2IP

146

A0A1B0GTH6
LSSSNPFFVRCIKPN

MYO10

626

Q9HD67
SPKPSVACSQLALLL

NRIP1

256

P48552
VNSFLPPACLAEAAV

KIF26A

236

Q9ULI4
KDCLPNFVTTNSCPL

LYPD4

151

Q6UWN0
NSLPPAVVGCASKAL

GCAT

296

O75600
LDSLPPVIKFCTSAA

NUP37

86

Q8NFH4
VRNCKFTSPGALPFI

NOC2L

341

Q9Y3T9
LNSSLTVPLQSCVKP

ERVK-7

1131

P63135
APKPVSVACTQLAFS

CASKIN2

1101

Q8WXE0
LQAGQLSCISFPPKE

DSTYK

86

Q6XUX3
SICPAAATFQVALSP

OBSCN

4701

Q5VST9
FPPLLSLACKDTSAN

OR6N2

181

Q8NGY6
LGKFCTTFSVPPLQT

CUBN

661

O60494
KAFLQFTTGCSTLPP

HECTD1

2536

Q9ULT8
LSPTAATVQFKCGAP

BCL6B

256

Q8N143
DPSQALPVIFGKSSC

DOCK6

581

Q96HP0
ICTFVSPAAQKAFQP

BRCA2

3286

P51587
KCVLNFPASPTSSIP

DENND2A

396

Q9ULE3
LNSSLTVPLQSCVKP

ERVK-25

371

P61570
LNSSLTVPLQSCVKP

ERVK-6

371

Q69384
VSKFSVCGFANPLPT

ENPP3

556

O14638
ALQLPKQCTFRFPST

FOXK1

181

P85037
APAVSVLQLFCSSPK

COPG2

286

Q9UBF2
CKSASIPLTVVAFIP

G6PC2

326

Q9NQR9
VKDSNQACLPPSSFI

MAPKBP1

401

O60336
PIIFALSNPTSKAEC

ME3

436

Q16798
PSCTSPLLVFVNSKS

DGKD

316

Q16760
VSSPKALFPVTLQCA

KLK9

151

Q9UKQ9
APAVSVLQLFCSSPK

COPG1

286

Q9Y678
LNSSLTVPLQSCVKP

HERVK_113

371

Q902F9
NSSLIRKFPQPTLVC

CCDC168

6686

Q8NDH2
QKVFTFLKNSCPPTS

GPX6

146

P59796
PSCHLIIPTFQDKSL

CEP295

1136

Q9C0D2
PNKTPVAAICLTSLV

SLC12A8

356

A0AV02
LCFLESTSNSKNVPP

RYR2

46

Q92736
PSFTSTPICGQKALI

MYBL1

506

P10243
AVQPKALNSCSIPVS

DPPA2

196

Q7Z7J5
ASSNCPTLNIKPVSL

PRR14L

726

Q5THK1
SSLSAPLPKLCVFVT

RTTN

1596

Q86VV8
PKTPFCFVINALSQR

PLEKHA2

76

Q9HB19
PLKICLPSVVNFFAA

RRN3

501

Q9NYV6
KCRTIASLLTAAPNP

SYNPO2L

276

Q9H987
TCAKLRLPPQATFQV

SUSD3

31

Q96L08
PASLSSNLVACVPSK

RAPGEF6

1551

Q8TEU7
VFATPLCCALFPQKS

SFXN3

276

Q9BWM7
TLQPTKQPNCSSLFK

PLD5

501

Q8N7P1
RSTAGCLPVPLFNQK

SPATA22

11

Q8NHS9
NKTDPCTLQFLAAPI

ALOX5

296

P09917
FLRKACSPSNIPAVI

ITPKB

556

P27987
CANALTSPPKVIRTF

SMG1

1001

Q96Q15
SKTLCHPISQFPSVL

PKD1L3

196

Q7Z443
KFKAPPCNTFVDLTS

SETX

596

Q7Z333
SQPCSKASIGLFVPA

SIRT4

21

Q9Y6E7
KPLTKSQPCLTSFNS

SECISBP2L

536

Q93073
TAPINKKQPFVCSSL

SUPV3L1

576

Q8IYB8
KFSAIQCAAAVPRAP

POLD3

131

Q15054
PQKASLPSACVFLSL

NPAP1

656

Q9NZP6
CFTASKAESLIPGPA

CLN6

196

Q9NWW5
AAKPPAICSPFSQDL

ZNF595

71

Q8IYB9
SPAFPSLIKNTGVAC

SPATA31A1

511

Q5TZJ5
VLQKLQDPCPSSLAS

SYBU

506

Q9NX95
LATSRTAPAAKNPCL

SH3RF3

181

Q8TEJ3
QPSPLALLAATCSKI

SP2

31

Q02086
SILSFCTSAIQKPPT

STC2

206

O76061
LPTCFKPQATVVSAS

TNKS

961

O95271
CEAFPKAVLAPSAIL

VWCE

261

Q96DN2
PLKICLPSVVNFFAA

RRN3P1

126

Q2M238
AECAFKTSPFPILLS

PLCB1

396

Q9NQ66
FTSAILPICLPSVTK

PRSS48

126

Q7RTY5
LSVLNQCRKAFSLPP

ZNF121

61

P58317
NCPAISLSKSLIPSI

ZNF217

696

O75362
SGFLLANPFKITCEP

SCN7A

1601

Q01118
VPCSQAPAKAQSALT

TASOR2

621

Q5VWN6
GTSCLPDTFTKLINP

GTF3C1

1701

Q12789
AFSIPLPIRQKLCSS

UNC5C

841

O95185
FEAKLTPCPQCSAVL

ZMYND15

321

Q9H091
NLPIPSTVLRKSCSA

ZNF318

1351

Q5VUA4
AFQPIASSCKIVPQS

YEATS2

426

Q9ULM3
TCQVTSFLAFSKPSP

TTI1

601

O43156
SCAAAASVVNPTPLL

UNCX

61

A6NJT0
KSPAPTQASQICLLL

nan

51

Q96M85
FGLSFTCPSLKNPIS

WNK3

1251

Q9BYP7
AFSLVKNARPSICPN

DUSP19

176

Q8WTR2
PQSSLVIPTSLFCKT

GUCY1A1

271

Q02108
CSFANPLPSVKITQV

NECTIN1

51

Q15223