Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	GRASP55/65_PDZ	GORASP2 GORASP1	8.51e-06	2	55	2	IPR024958
Domain	GRASP55_65	GORASP2 GORASP1	8.51e-06	2	55	2	IPR007583
Domain	GRASP55_65	GORASP2 GORASP1	8.51e-06	2	55	2	PF04495
Domain	Ago_hook	TNRC6A TNRC6B	2.55e-05	3	55	2	PF10427
Domain	TNRC6_PABC-bd	TNRC6A TNRC6B	2.55e-05	3	55	2	IPR032226
Domain	Argonaute_hook_dom	TNRC6A TNRC6B	2.55e-05	3	55	2	IPR019486
Domain	TNRC6-PABC_bdg	TNRC6A TNRC6B	2.55e-05	3	55	2	PF16608
Domain	RRM	TNRC6A HNRNPA0 TNRC6B ELAVL3 HNRNPAB	5.71e-04	230	55	5	PS50102
Domain	-	TNRC6A HNRNPA0 TNRC6B ELAVL3 HNRNPAB	7.46e-04	244	55	5	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	TNRC6A HNRNPA0 TNRC6B ELAVL3 HNRNPAB	9.58e-04	258	55	5	IPR012677
Domain	-	MYCBP2 UBR5	1.89e-03	22	55	2	2.130.10.30
Domain	RCC1/BLIP-II	MYCBP2 UBR5	2.07e-03	23	55	2	IPR009091
Domain	RRM	TNRC6A HNRNPA0 ELAVL3 HNRNPAB	3.80e-03	217	55	4	SM00360
Domain	RRM_dom	TNRC6A HNRNPA0 ELAVL3 HNRNPAB	4.46e-03	227	55	4	IPR000504
Domain	Ion_trans_dom	CACNA1C KCNH1 RYR1	4.61e-03	114	55	3	IPR005821
Domain	Ion_trans	CACNA1C KCNH1 RYR1	4.61e-03	114	55	3	PF00520
Pathway	REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS	TNRC6A TNRC6B	1.55e-04	6	46	2	MM15083
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1C PRNP	1.55e-04	6	46	2	M47762
Pathway	REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS	TNRC6A TNRC6B	2.16e-04	7	46	2	M46421
Pathway	REACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION	TNRC6A TNRC6B	3.70e-04	9	46	2	M27810
Pathway	REACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION	TNRC6A TNRC6B	3.70e-04	9	46	2	M46436
Pathway	REACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS	TNRC6A TNRC6B	4.61e-04	10	46	2	M48013
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	CACNA1C RYR1	5.62e-04	11	46	2	M47958
Pathway	REACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION	TNRC6A TNRC6B	7.94e-04	13	46	2	M46434
Pathway	REACTOME_GOLGI_CISTERNAE_PERICENTRIOLAR_STACK_REORGANIZATION	GORASP2 GORASP1	9.25e-04	14	46	2	M26983
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	AKAP8 UBR5 DSP TNRC6A TNRC6B HRNR RFX5	3.98e-08	184	62	7	32908313
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	CAAP1 KRT78 AKAP8 MYCBP2 VWA8 DSP HECTD4 HNRNPA0 TNRC6B ELAVL3 HRNR HNRNPAB	3.98e-07	1082	62	12	38697112
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	IRS4 MYCBP2 UBR5 DSP NACC1 PHF12 TNRC6A TNRC6B	7.81e-07	418	62	8	34709266
Pubmed	Ring finger protein 12 activates AKT signalling to promote the progression of liver cancer by interacting with EGFR.	KRT78 IRS4 DSP ARPC1A TNRC6A HRNR PRNP	8.47e-07	289	62	7	37132043
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CAAP1 OSBP AKAP8 MYCBP2 NFIA DSP NACC1 PHF12 PFKP VIRMA	1.06e-06	774	62	10	15302935
Pubmed	Revealing A-Raf functions through its interactome.	IRS4 AKAP8 DSP HNRNPA0 HRNR PFKP	1.07e-06	187	62	6	29777862
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	AKAP8 MYCBP2 TNRC6A HNRNPA0 TNRC6B ELAVL3 FAM98A HNRNPAB	1.65e-06	462	62	8	31138677
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	KRT78 IRS4 AKAP8 MYCBP2 UBR5 DSP ARPC1A HNRNPA0 HRNR PFKP HNRNPAB	1.76e-06	1024	62	11	24711643
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	AKAP8 DSP TNRC6A HNRNPA0 TNRC6B FAM98A PFKP HNRNPAB	2.70e-06	494	62	8	26831064
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KRT78 IRS4 ABL2 AKAP8 MYCBP2 DSP FAM98A PFKP VIRMA GARRE1	2.76e-06	861	62	10	36931259
Pubmed	Isoform-specific tethering links the Golgi ribbon to maintain compartmentalization.	GORASP2 GORASP1	3.13e-06	2	62	2	24227884
Pubmed	GRASP55 and GRASP65 play complementary and essential roles in Golgi cisternal stacking.	GORASP2 GORASP1	3.13e-06	2	62	2	20083603
Pubmed	Role of GW182 protein in the cell.	TNRC6A TNRC6B	3.13e-06	2	62	2	29791863
Pubmed	Identification of MKRN1 as a second E3 ligase for Eag1 potassium channels reveals regulation via differential degradation.	KCNH1 MKRN1	3.13e-06	2	62	2	33647316
Pubmed	The Truncated Isoform of the Receptor Tyrosine Kinase ALK Generated by Alternative Transcription Initiation (ALKATI) Induces Chromatin Structural Changes in the Nucleus in a Kinase Activity-Dependent Manner.	AKAP8 ALK	3.13e-06	2	62	2	29093346
Pubmed	Rapid degradation of GRASP55 and GRASP65 reveals their immediate impact on the Golgi structure.	GORASP2 GORASP1	3.13e-06	2	62	2	33301566
Pubmed	Knockout of the Golgi stacking proteins GRASP55 and GRASP65 impairs Golgi structure and function.	GORASP2 GORASP1	3.13e-06	2	62	2	28814501
Pubmed	Identification of a novel GORASP2-ALK fusion in an ALK-positive large B-cell lymphoma.	GORASP2 ALK	3.13e-06	2	62	2	30187817
Pubmed	Regulation of protein glycosylation and sorting by the Golgi matrix proteins GRASP55/65.	GORASP2 GORASP1	3.13e-06	2	62	2	23552074
Pubmed	The function of GORASPs in Golgi apparatus organization in vivo.	GORASP2 GORASP1	3.13e-06	2	62	2	32573693
Pubmed	VIRMA promotes the progression of head and neck squamous cell carcinoma by regulating UBR5 mRNA and m6A levels.	UBR5 VIRMA	3.13e-06	2	62	2	38577917
Pubmed	Ryanodine receptor activation by Ca v 1.2 is involved in dendritic cell major histocompatibility complex class II surface expression.	CACNA1C RYR1	3.13e-06	2	62	2	18927079
Pubmed	GRASP65 and GRASP55 sequentially promote the transport of C-terminal valine-bearing cargos to and through the Golgi complex.	GORASP2 GORASP1	3.13e-06	2	62	2	19840934
Pubmed	GRASP depletion-mediated Golgi fragmentation impairs glycosaminoglycan synthesis, sulfation, and secretion.	GORASP2 GORASP1	3.13e-06	2	62	2	35312866
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	IRS4 MYCBP2 TNRC6A TNRC6B VIRMA GARRE1	4.73e-06	242	62	6	34011540
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	CAAP1 KRT78 TRIR AKAP8 MYCBP2 TNRC6A TNRC6B FAM98A ZFC3H1	5.29e-06	724	62	9	36232890
Pubmed	Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop.	AKAP8 DSP HNRNPA0 FAM98A HRNR HNRNPAB	7.13e-06	260	62	6	36199071
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	ADRA2C UBR5 VWA8 DSP ZC3HAV1L FAM98A GRIP2 HRNR HNRNPAB	7.33e-06	754	62	9	35906200
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	AKAP8 MYCBP2 UBR5 NACC1 HECTD4 TNRC6B ELAVL3 ARMCX4 VIRMA KCNT1	7.38e-06	963	62	10	28671696
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	MYCBP2 UBR5 DSP ARPC1A HECTD4 HRNR	7.78e-06	264	62	6	32814769
Pubmed	Rescue of ΔF508-CFTR trafficking via a GRASP-dependent unconventional secretion pathway.	GORASP2 GORASP1	9.37e-06	3	62	2	21884936
Pubmed	Triad proteins and intracellular Ca2+ transients during development of human skeletal muscle cells in aneural and innervated cultures.	CACNA1C RYR1	9.37e-06	3	62	2	11206130
Pubmed	Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.	TNRC6A TNRC6B	9.37e-06	3	62	2	34108231
Pubmed	GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system.	GORASP2 GORASP1	9.37e-06	3	62	2	10487747
Pubmed	Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.	TNRC6A TNRC6B	9.37e-06	3	62	2	16880270
Pubmed	Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.	TNRC6A TNRC6B	9.37e-06	3	62	2	31670606
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	KRT78 AKAP8 DSP HNRNPA0 FAM98A HRNR VIRMA HNRNPAB	1.19e-05	605	62	8	28977666
Pubmed	ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia.	IRS4 AKAP8 TNRC6A TNRC6B HRNR	1.21e-05	166	62	5	35687106
Pubmed	Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.	KRT78 UBR5 DSP HRNR	1.59e-05	84	62	4	29563501
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	AKAP8 NFIA TNRC6A HNRNPA0 PFKP	1.79e-05	180	62	5	35198878
Pubmed	Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing.	TNRC6A TNRC6B	1.87e-05	4	62	2	21063388
Pubmed	Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis.	GORASP2 GORASP1	1.87e-05	4	62	2	11815631
Pubmed	The MLLE domain of the ubiquitin ligase UBR5 binds to its catalytic domain to regulate substrate binding.	UBR5 TNRC6A	1.87e-05	4	62	2	26224628
Pubmed	UBE2O promotes lipid metabolic reprogramming and liver cancer progression by mediating HADHA ubiquitination.	IRS4 TRIR DSP MKRN1 ARPC1A TNRC6A FAM98A	2.69e-05	491	62	7	36273042
Pubmed	NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.	HIVEP3 DSP HNRNPA0 CCDC180 VIRMA HNRNPAB	2.88e-05	333	62	6	32665550
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	IRS4 MYCBP2 VWA8 ZFC3H1 VIRMA	3.11e-05	202	62	5	24639526
Pubmed	The p90 ribosomal S6 kinase-UBR5 pathway controls Toll-like receptor signaling via miRNA-induced translational inhibition of tumor necrosis factor receptor-associated factor 3.	UBR5 TNRC6A	3.12e-05	5	62	2	28559278
Pubmed	Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout.	CACNA1C RYR1	3.12e-05	5	62	2	22355118
Pubmed	Human prion protein binds Argonaute and promotes accumulation of microRNA effector complexes.	TNRC6A PRNP	3.12e-05	5	62	2	22484317
Pubmed	hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.	KRT78 AKAP8 DSP HNRNPA0 HRNR HNRNPAB	3.57e-05	346	62	6	25324306
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	IRS4 AKAP8 VWA8 ARPC1A HNRNPA0 TNRC6B FAM98A VIRMA HNRNPAB	3.58e-05	922	62	9	27609421
Pubmed	Human transcription factor protein interaction networks.	IRS4 AKAP8 NFIA NACC1 PHF12 TNRC6A TNRC6B HRNR PFKP RFX5 GARRE1	4.01e-05	1429	62	11	35140242
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	KRT78 SHROOM1 MYCBP2 HNRNPA0 ELAVL3 ZFC3H1	4.52e-05	361	62	6	26167880
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	CAAP1 IRS4 TRIR DSP HNRNPA0 FAM98A RFX5 ALK HNRNPAB	4.67e-05	954	62	9	36373674
Pubmed	A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic.	GORASP2 GORASP1	4.67e-05	6	62	2	11739401
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CAAP1 GORASP2 AKAP8 PHF12 MKRN1 TNRC6A TNRC6B FAM98A ZFC3H1 PFKP VIRMA	6.09e-05	1497	62	11	31527615
Pubmed	TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.	MYCBP2 DSP TNRC6A GRIP2 HRNR CCDC180	6.18e-05	382	62	6	37249651
Pubmed	The isolation and characterization of the murine T cell antigen receptor zeta chain gene.	ABL2 ALK	6.53e-05	7	62	2	2787796
Pubmed	Functional dissection of the human TNRC6 (GW182-related) family of proteins.	TNRC6A TNRC6B	6.53e-05	7	62	2	19470757
Pubmed	The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.	TNRC6A TNRC6B	6.53e-05	7	62	2	19383768
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	KRT78 AKAP8 DSP ARPC1A HNRNPA0 ZFC3H1 HRNR PFKP VIRMA HNRNPAB	7.14e-05	1257	62	10	36526897
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	IRS4 AKAP8 MYCBP2 UBR5 DSP HNRNPA0 TNRC6B FAM98A PFKP HNRNPAB	7.14e-05	1257	62	10	37317656
Pubmed	Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus.	GORASP2 GORASP1	8.69e-05	8	62	2	11739402
Pubmed	Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.	CACNA1C RYR1	8.69e-05	8	62	2	11784029
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	HIVEP3 IRS4 MYCBP2 NFIA DSP MUC19 PFKP RYR1	9.08e-05	807	62	8	30575818
Pubmed	Mammalian hyperplastic discs homolog EDD regulates miRNA-mediated gene silencing.	UBR5 TNRC6A	1.12e-04	9	62	2	21726813
Pubmed	Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network.	MKRN1 FAM98A HNRNPAB	1.12e-04	52	62	3	26265008
Pubmed	TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.	TNRC6A HNRNPA0 TNRC6B FAM98A HRNR HNRNPAB	1.18e-04	430	62	6	38172120
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	IRS4 AKAP8 TNRC6A HNRNPA0 HNRNPAB	1.31e-04	274	62	5	34244482
Pubmed	The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation.	AKAP8 MKRN1 TNRC6B	1.32e-04	55	62	3	31640799
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	IRS4 AKAP8 MYCBP2 UBR5 HECTD4 ZFC3H1	1.34e-04	440	62	6	34244565
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	IRS4 UBR5 NACC1 TNRC6A TNRC6B GARRE1	1.44e-04	446	62	6	24255178
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	CAAP1 TRIR AKAP8 VWA8 DSP TNRC6A TNRC6B FAM98A VIRMA ALK	1.46e-04	1371	62	10	36244648
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CAAP1 AKAP8 UBR5 VWA8 NACC1 PHF12 TNRC6A TNRC6B GARRE1	1.54e-04	1116	62	9	31753913
Pubmed	Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1.	UBR5 STYXL2 PFKP	1.55e-04	58	62	3	31067491
Pubmed	Identification and comparative analysis of hepatitis C virus-host cell protein interactions.	GORASP2 MYCBP2	1.70e-04	11	62	2	24136289
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	OSBP MYCBP2 VWA8 DSP TNRC6A HNRNPA0 TNRC6B HNRNPAB PRNP	1.79e-04	1139	62	9	36417873
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	TRIR UBR5 VWA8 DSP ZC3HAV1L HNRNPA0 TNRC6B FAM98A PFKP HNRNPAB	1.88e-04	1415	62	10	28515276
Pubmed	A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.	KRT78 DSP HRNR	1.89e-04	62	62	3	26644517
Pubmed	DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis.	DSP HRNR PFKP	1.98e-04	63	62	3	37052853
Pubmed	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.	IRS4 AKAP8 DSP HNRNPA0 TNRC6B FAM98A HNRNPAB	2.01e-04	678	62	7	30209976
Pubmed	New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.	CACNA1C RYR1	2.04e-04	12	62	2	19095005
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	KRT78 DSP ARPC1A HNRNPA0 ELAVL3 FAM98A PFKP VIRMA HNRNPAB PRNP	2.06e-04	1431	62	10	37142655
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	TRIR MYCBP2 TNRC6A TNRC6B PRNP	2.22e-04	307	62	5	37499664
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	IRS4 HNRNPA0 FAM98A ZFC3H1 PFKP HNRNPAB	2.29e-04	486	62	6	30940648
Pubmed	Large-scale analysis of the human ubiquitin-related proteome.	HIVEP3 MYCBP2 TNRC6A HNRNPA0 TNRC6B	2.43e-04	313	62	5	16196087
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	GORASP2 IRS4 TRIR DSP NACC1 TNRC6B PFKP HNRNPAB	2.46e-04	934	62	8	33916271
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	CAAP1 GORASP1 HNRNPA0 HRNR GARRE1 HNRNPAB	2.75e-04	503	62	6	36217030
Pubmed	Proximity labeling reveals dynamic changes in the SQSTM1 protein network.	ARPC1A ZC3HAV1L TNRC6A TNRC6B HNRNPAB	2.77e-04	322	62	5	39098523
Pubmed	Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.	TNRC6A TNRC6B	2.81e-04	14	62	2	19716330
Pubmed	PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78.	DSP HRNR	2.81e-04	14	62	2	29178343
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	IRS4 DSP HNRNPA0 FAM98A ZFC3H1 VIRMA HNRNPAB	3.18e-04	731	62	7	29298432
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	IRS4 AKAP8 UBR5 MKRN1 HNRNPA0 TNRC6B FAM98A HNRNPAB	3.19e-04	971	62	8	33306668
Pubmed	GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.	TNRC6A TNRC6B	3.23e-04	15	62	2	21981923
Pubmed	Engagement of the G3BP2-TRIM25 Interaction by Nucleocapsid Protein Suppresses the Type I Interferon Response in SARS-CoV-2-Infected Cells.	KRT78 IRS4 DSP	3.46e-04	76	62	3	36560452
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	IRS4 AKAP8 MUC19 HNRNPA0 HNRNPAB	3.51e-04	339	62	5	30415952
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	VWA8 PHF12 HECTD4 TNRC6A KCNT1 GARRE1	3.60e-04	529	62	6	14621295
Pubmed	TRIM30 modulates Interleukin-22-regulated papillary thyroid Cancer cell migration and invasion by targeting Sox17 for K48-linked Polyubiquitination.	DSP HRNR	3.69e-04	16	62	2	31823782
Pubmed	Differential physiological roles for BIN1 isoforms in skeletal muscle development, function and regeneration.	CACNA1C RYR1	3.69e-04	16	62	2	32994313
Pubmed	Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.	MYCBP2 HECTD4 PANK1 VIRMA	3.76e-04	190	62	4	15161933
Interaction	COPS5 interactions	CACNA1C OSBP KRT78 IRS4 AKAP8 DSP ZC3HAV1L HNRNPA0 TNRC6B FAM98A HRNR PFKP VIRMA HNRNPAB	4.86e-06	1102	62	14	int:COPS5
Interaction	N4BP2 interactions	TNRC6B FAM98A VIRMA GARRE1 HNRNPAB	7.96e-06	89	62	5	int:N4BP2
Interaction	AR interactions	ABL2 MYCBP2 UBR5 NFIA DSP PHF12 ARPC1A HECTD4 HNRNPA0 HRNR RFX5 VIRMA HNRNPAB	8.08e-06	992	62	13	int:AR
Interaction	MYCN interactions	KRT78 IRS4 TRIR AKAP8 DSP MKRN1 HNRNPA0 TNRC6B ELAVL3 FAM98A ZFC3H1 HRNR VIRMA HNRNPAB PRNP	1.30e-05	1373	62	15	int:MYCN
Interaction	KIF20A interactions	AKAP8 UBR5 VWA8 DSP HECTD4 TNRC6A HNRNPA0 TNRC6B FAM98A VIRMA TET3 HNRNPAB PRNP	1.51e-05	1052	62	13	int:KIF20A
Interaction	ANKHD1-EIF4EBP3 interactions	TNRC6A TNRC6B ZFC3H1 VIRMA GARRE1	2.04e-05	108	62	5	int:ANKHD1-EIF4EBP3
Interaction	BTRC interactions	AKAP8 MYCBP2 DSP ZC3HAV1L TNRC6A HNRNPA0 TNRC6B FAM98A HRNR CCDC180 HNRNPAB	2.15e-05	775	62	11	int:BTRC
Interaction	UBE2O interactions	IRS4 TRIR AKAP8 UBR5 DSP MKRN1 ARPC1A TNRC6A FAM98A VIRMA PRNP	2.56e-05	790	62	11	int:UBE2O
Interaction	RLIM interactions	KRT78 IRS4 NFIA DSP ARPC1A TNRC6A HRNR PRNP	2.58e-05	392	62	8	int:RLIM
Interaction	METTL3 interactions	UBR5 DSP KCNH1 HRNR PFKP VIRMA RYR1	2.78e-05	287	62	7	int:METTL3
Interaction	TNIP2 interactions	CACNA1C IRS4 AKAP8 VWA8 ARPC1A TNRC6A HNRNPA0 TNRC6B FAM98A VIRMA GARRE1 HNRNPAB	2.80e-05	952	62	12	int:TNIP2
Interaction	WTAP interactions	KRT78 UBR5 DSP HRNR VIRMA PRNP	2.89e-05	194	62	6	int:WTAP
Interaction	CYLD interactions	KRT78 DSP TNRC6A MUC19 TNRC6B HRNR VIRMA ALK GARRE1 HNRNPAB PRNP	6.03e-05	868	62	11	int:CYLD
Interaction	TNRC6C interactions	DSP TNRC6A TNRC6B VIRMA GARRE1	6.62e-05	138	62	5	int:TNRC6C
Interaction	FAM193A interactions	TNRC6A TNRC6B VIRMA GARRE1	6.76e-05	71	62	4	int:FAM193A
Interaction	CRKL interactions	IRS4 ABL2 ASAP3 ALK GARRE1 PRNP	6.94e-05	227	62	6	int:CRKL
Interaction	PHF21A interactions	IRS4 MYCBP2 UBR5 DSP PHF12 TNRC6A TNRC6B	8.57e-05	343	62	7	int:PHF21A
Interaction	AGO2 interactions	UBR5 MKRN1 TNRC6A TNRC6B PFKP VIRMA GARRE1 HNRNPAB	9.52e-05	472	62	8	int:AGO2
Interaction	SNRPA interactions	CAAP1 TRIR AKAP8 HNRNPA0 ZFC3H1 VIRMA HNRNPAB PRNP	1.10e-04	482	62	8	int:SNRPA
Interaction	CPEB4 interactions	TNRC6A TNRC6B FAM98A VIRMA GARRE1	1.18e-04	156	62	5	int:CPEB4
Interaction	ACE2 interactions	CACNA1C GORASP2 KRT78 IRS4 DSP ARPC1A HNRNPA0 FAM98A HRNR PFKP HNRNPAB PRNP	1.19e-04	1106	62	12	int:ACE2
Interaction	MECP2 interactions	CAAP1 KRT78 AKAP8 MYCBP2 VWA8 DSP HECTD4 HNRNPA0 TNRC6B ELAVL3 HRNR HNRNPAB PRNP	1.22e-04	1287	62	13	int:MECP2
Interaction	SERINC5 interactions	MYCBP2 UBR5 VIRMA	1.29e-04	32	62	3	int:SERINC5
Interaction	RCOR1 interactions	IRS4 MYCBP2 UBR5 DSP PHF12 TNRC6B VIRMA PRNP	1.30e-04	494	62	8	int:RCOR1
Interaction	HELZ interactions	MKRN1 TNRC6A TNRC6B FAM98A VIRMA GARRE1	1.37e-04	257	62	6	int:HELZ
Interaction	ADPRHL1 interactions	VIRMA PRNP	1.39e-04	6	62	2	int:ADPRHL1
Interaction	SPATA2 interactions	TNRC6A TNRC6B VIRMA GARRE1	1.49e-04	87	62	4	int:SPATA2
Interaction	MKRN1 interactions	AKAP8 KCNH1 MKRN1 TNRC6B PRNP	1.54e-04	165	62	5	int:MKRN1
Interaction	GARRE1 interactions	SHROOM1 TNRC6A TNRC6B VIRMA GARRE1	1.63e-04	167	62	5	int:GARRE1
Interaction	CCDC8 interactions	KRT78 IRS4 AKAP8 MYCBP2 UBR5 DSP HNRNPA0 HRNR PFKP	1.69e-04	656	62	9	int:CCDC8
Interaction	GARS1 interactions	OSBP GORASP2 VWA8 TNRC6B VIRMA PRNP	1.79e-04	270	62	6	int:GARS1
Interaction	RC3H2 interactions	IRS4 AKAP8 DSP TNRC6A HNRNPA0 TNRC6B FAM98A VIRMA HNRNPAB	1.91e-04	667	62	9	int:RC3H2
Interaction	CNOT6L interactions	TNRC6A TNRC6B VIRMA GARRE1	1.93e-04	93	62	4	int:CNOT6L
Interaction	COL15A1 interactions	COL15A1 VIRMA	1.94e-04	7	62	2	int:COL15A1
Interaction	MPHOSPH9 interactions	TNRC6A TNRC6B VIRMA GARRE1	2.10e-04	95	62	4	int:MPHOSPH9
Interaction	ACTN4 interactions	OSBP UBR5 ARPC1A VIRMA ALK HNRNPAB PRNP	2.21e-04	400	62	7	int:ACTN4
Interaction	TNRC6B interactions	DSP MKRN1 TNRC6A TNRC6B VIRMA GARRE1	2.27e-04	282	62	6	int:TNRC6B
Interaction	FMR1 interactions	AKAP8 MYCBP2 TNRC6B ELAVL3 GRIP2 VIRMA KCNT1 HNRNPAB	2.27e-04	536	62	8	int:FMR1
Interaction	BTG3 interactions	MYCBP2 HECTD4 TNRC6A TNRC6B	2.36e-04	98	62	4	int:BTG3
Interaction	TRIM21 interactions	MYCBP2 VWA8 DSP TNRC6A GRIP2 HRNR PFKP CCDC180 VIRMA	2.43e-04	689	62	9	int:TRIM21
Interaction	AGO1 interactions	TNRC6A TNRC6B VIRMA GARRE1 PRNP	2.49e-04	183	62	5	int:AGO1
Interaction	PUM1 interactions	MKRN1 TNRC6A TNRC6B FAM98A VIRMA GARRE1	2.49e-04	287	62	6	int:PUM1
Interaction	QSER1 interactions	KRT78 NFIA PHF12 VIRMA	2.55e-04	100	62	4	int:QSER1
Interaction	MIB1 interactions	IRS4 TNRC6A TNRC6B ZFC3H1 VIRMA PRNP	2.89e-04	295	62	6	int:MIB1
Interaction	FOXC2 interactions	AKAP8 NFIA PRNP	2.92e-04	42	62	3	int:FOXC2
Interaction	UBAP2L interactions	UBR5 TNRC6A TNRC6B FAM98A VIRMA GARRE1	3.05e-04	298	62	6	int:UBAP2L
Interaction	SSH2 interactions	MYCBP2 VIRMA PRNP	3.13e-04	43	62	3	int:SSH2
Interaction	NUDCD2 interactions	HIVEP3 DSP HNRNPA0 CCDC180 VIRMA HNRNPAB PRNP	3.15e-04	424	62	7	int:NUDCD2
Interaction	MYLK interactions	VIRMA ALK HNRNPAB PRNP	3.19e-04	106	62	4	int:MYLK
Interaction	DDX39B interactions	CAAP1 KRT78 UBR5 DSP ZFC3H1 HRNR PFKP VIRMA	3.44e-04	570	62	8	int:DDX39B
Interaction	PHIP interactions	MKRN1 TNRC6A TNRC6B VIRMA GARRE1	3.49e-04	197	62	5	int:PHIP
Interaction	YWHAG interactions	IRS4 SHROOM1 ABL2 AKAP8 MYCBP2 DSP HECTD4 FAM98A PFKP VIRMA GARRE1 HNRNPAB	3.64e-04	1248	62	12	int:YWHAG
Interaction	ARMC5 interactions	IRS4 AKAP8 TNRC6A TNRC6B HRNR	3.83e-04	201	62	5	int:ARMC5
Interaction	CNOT11 interactions	TNRC6A TNRC6B GARRE1 PRNP	3.93e-04	112	62	4	int:CNOT11
Interaction	TBR1 interactions	MYCBP2 NFIA VIRMA PRNP	4.07e-04	113	62	4	int:TBR1
Interaction	ELAPOR2 interactions	VIRMA PRNP	4.12e-04	10	62	2	int:ELAPOR2
Interaction	CUL2 interactions	KRT78 IRS4 DSP HNRNPA0 TNRC6B FAM98A HRNR HNRNPAB	4.37e-04	591	62	8	int:CUL2
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	SHROOM1 RELL2 WNT8A HNRNPA0	7.22e-04	298	62	4	chr5q31
Cytoband	19p13.2	TRIR NACC1 ELAVL3	3.73e-03	229	62	3	19p13.2
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	HIVEP3 CACNA1C MYCBP2 ATRNL1 ELAVL3 GRIP2	3.58e-07	200	62	6	bad32a95b759fad509401b07bc96a56687c2a592
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal-GABAergic_neurons\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	MYCBP2 RELL2 ATRNL1 GRIP2 GALR2	3.31e-06	164	62	5	4d7b2d0980fb4f47721fa2891151e2bd892ccb91
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	UBR5 DSP TNRC6A TNRC6B ZFC3H1	7.14e-06	192	62	5	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	UBR5 DSP TNRC6A TNRC6B ZFC3H1	7.32e-06	193	62	5	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	UBR5 NFIA VWA8 TNRC6A TNRC6B	8.49e-06	199	62	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
Disease	Sudden Cardiac Death	CACNA1C DSP	1.06e-04	8	58	2	C0085298
Disease	risk-taking behaviour	HIVEP3 CACNA1C CAAP1 NFIA ATRNL1 MKRN1 TNRC6A TET3	1.19e-04	764	58	8	EFO_0008579
Disease	gestational age	HIVEP3 UBR5 TET3 ALK	1.60e-04	138	58	4	EFO_0005112
Disease	Depressive disorder	CACNA1C GALR2 ALK PRNP TG	2.61e-04	289	58	5	C0011581
Disease	Neurodevelopmental Disorders	HIVEP3 KCNH1 TNRC6B	8.25e-04	93	58	3	C1535926
Disease	alcohol use disorder measurement, alcohol consumption measurement	CACNA1C ARPC1A TNRC6A	9.32e-04	97	58	3	EFO_0007878, EFO_0009458
Disease	Involutional paraphrenia	CACNA1C GALR2	1.11e-03	25	58	2	C1571983
Disease	Psychosis, Involutional	CACNA1C GALR2	1.11e-03	25	58	2	C1571984
Disease	Involutional Depression	CACNA1C GALR2	1.11e-03	25	58	2	C0011574
Disease	congestive heart failure (is_implicated_in)	ADRA2C RYR1	1.29e-03	27	58	2	DOID:6000 (is_implicated_in)
Disease	Unipolar Depression	CACNA1C AKAP8 GALR2 TG	1.70e-03	259	58	4	C0041696

Protein segments in the cluster

Peptide	Gene	Start	Entry
SAGPGSWGSAGHDGE	ASAP3	406	Q8TDY4
GGSGTAGGGWSGITG	ABL2	736	P42684
GGYGAWSAGPANTQG	AKAP8	6	O43823
RGSGGVANASGASWG	ADRA2C	26	P18825
GRNGGRGGWSDNGCS	ADGRG2	576	Q8IZP9
AGVGLSGGAAGAGWC	ELAVL3	271	Q14576
SGSVTGGGSGGSCWG	CAAP1	61	Q9H8G2
GGGSGGSCWGGSSVE	CAAP1	66	Q9H8G2
WACGSRGSSEAGAGG	CCDC180	1286	Q9P1Z9
QASGGLWAGGQTSEG	ARMCX4	1186	Q5H9R4
GGSWAGTSDQSGGGS	ARMCX4	1301	Q5H9R4
DQASGEGSWAGAGGQ	ARMCX4	1321	Q5H9R4
EGSWAGAGGQASGGS	ARMCX4	1326	Q5H9R4
TTEEGSWAGAGGQAG	ARMCX4	1396	Q5H9R4
SWAGAGGQAGGGSKV	ARMCX4	1401	Q5H9R4
NGGSWTGAGHPASVG	ARMCX4	1446	Q5H9R4
SQTNGGSWGGASGQD	ARMCX4	1516	Q5H9R4
GSWGGASGQDVGGSR	ARMCX4	1521	Q5H9R4
GSCWTGAGAVDQAGG	ARMCX4	1556	Q5H9R4
SGGSWAGTGNQSSGR	ARMCX4	1631	Q5H9R4
ACGGGSWAGAGSQAS	ARMCX4	1666	Q5H9R4
SEFGGSGTGGWVHGV	ARPC1A	196	Q92747
GQGRSPGSGSQSSGW	NFIA	296	Q12857
ETWGSGGEGNSAGGA	RFX5	501	P48382
NSAWGGEGSLGCGIG	GORASP2	181	Q9H8Y8
GPWGSRAGTGGSSQG	KCNT1	1051	Q5JUK3
SGGNTWSSDSGSGGG	MUC19	426	Q7Z5P9
GSPGHFSGGTTEWGN	MUC19	1871	Q7Z5P9
IGWTDVGGWTGQGGS	PFKP	461	Q01813
GQHGSGSGWSSSNGP	HRNR	676	Q86YZ3
QFNGSGSGKWEGGPS	KCNH1	431	O95259
GCLEGSRGSTWGSGG	KRT78	46	Q8N1N4
QNWVSGGACGGSGGA	HECTD4	2806	Q9Y4D8
GSGAGGSGSAREGWL	OSBP	81	P22059
NAAWGGEGSLGCGIG	GORASP1	181	Q9BQQ3
NASQAGGGGGWHPEA	GALR2	11	O43603
GSWAETTPGGGGSSA	CACNA1C	2076	Q13936
SKGGGGYTCQSGSGW	DSP	166	P15924
GDGLHGGWSGAQGDS	GARRE1	896	O15063
GGGGGGASSWLLDGN	ATRNL1	26	Q5VV63
SWDSSATEGGFGGPG	GRIP2	786	Q9C0E4
GLGWGSDVGSGSGDL	COL15A1	596	P39059
VSGAGSGGSSGWGLG	RYR1	4601	P21817
SGGSSGWGLGAGEEA	RYR1	4606	P21817
AGAGAAAEAPGGQWG	CRLS1	81	Q9UJA2
GAWAGEGTAGGAALG	IRGQ	561	Q8WZA9
GGGGGQDWACSVAGT	PANK1	6	Q8TE04
NNWGSGNGRGSGGGQ	IRS4	491	O14654
GGSDGSGGGWTKQVT	MKRN1	46	Q9UHC7
RAGGAASGGGGNSWD	RPIA	21	P49247
ASGGGGNSWDLPGSH	RPIA	26	P49247
GSPTDRSWGSGGGQD	RELL2	186	Q8NC24
GWTGAAAGAGGATAA	HNRNPAB	31	Q99729
GNKHQGGWTDGGSGG	FAM98A	376	Q8NCA5
SSLIGGSGAGWEGTA	PHF12	931	Q96QT6
SASGEVLGSWGGSGG	SHROOM1	306	Q2M3G4
GWAGNCGDGGIGGST	MYCBP2	3281	O75592
NGNSGAAGGGGGWND	ALK	871	Q9UM73
GSQGNWGLTSSGAGQ	LINC01561	46	Q8N1V8
GGGSSWGGRSNSGPY	HNRNPA0	276	Q13151
PQDGGGWRSASSGQG	STYXL2	366	Q5VZP5
GPTAAWVSGFSGGGS	HIVEP3	2216	Q5T1R4
WVSGFSGGGSDLTGA	HIVEP3	2221	Q5T1R4
GGGWGQGGGTHSQWN	PRNP	86	P04156
GVGGSWGVFSSGESP	TET3	1451	O43151
WAAAAAAGGAGGPGS	UBE2Z	46	Q9H832
AQGDGPTSGHWDGGA	TBC1D20	6	Q96BZ9
GSNNGKTGGHGWIWG	WNT8A	116	Q9H1J5
GNTWAGGTGGRDTAG	VWA8	1566	A3KMH1
GFLSSGSGEVSGNWG	TG	2341	P01266
GGLGPSWASANSGSG	VIRMA	1776	Q69YN4
LGGGAGSGFSSSQSW	ZFC3H1	176	O60293
WGSGNGANSGGSRRG	TNRC6A	586	Q8NDV7
GGGGGSRWAESGSGT	TRIR	21	Q9BQ61
GTWGNGGNASLASKG	TNRC6B	781	Q9UPQ9
FGGSTGLGQWSSSAG	TNRC6B	1766	Q9UPQ9
GLGQWSSSAGGSSGA	TNRC6B	1771	Q9UPQ9
RWSSGVGGSGGGSSG	UBR5	131	O95071
EAAAGAVGGGGTSAW	ZC3HAV1L	66	Q96H79
WDSGQKEAGGGGNGS	NACC1	186	Q96RE7