Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	semaphorin receptor activity	PLXNB2 PLXNA4 PLXNB1	2.67e-05	12	101	3	GO:0017154
GeneOntologyBiologicalProcess	luteinizing hormone signaling pathway involved in ovarian follicle development	CGB7 LHB CGB1	1.13e-06	5	101	3	GO:0035471
GeneOntologyBiologicalProcess	luteinizing hormone signaling pathway	CGB7 LHB CGB1	3.93e-06	7	101	3	GO:0042700
GeneOntologyBiologicalProcess	multi-pass transmembrane protein insertion into ER membrane	NOMO1 NOMO2 NOMO3	9.37e-06	9	101	3	GO:0160063
GeneOntologyCellularComponent	pituitary gonadotropin complex	CGB3 CGB7 LHB CGB1	3.54e-08	8	101	4	GO:0061696
GeneOntologyCellularComponent	multi-pass translocon complex	NOMO1 NOMO2 NOMO3	9.00e-06	9	101	3	GO:0160064
GeneOntologyCellularComponent	semaphorin receptor complex	PLXNB2 PLXNA4 PLXNB1	3.02e-05	13	101	3	GO:0002116
GeneOntologyCellularComponent	ER membrane insertion complex	NOMO1 NOMO2 NOMO3	3.83e-05	14	101	3	GO:0072379
MousePheno	small vulva	CGB7 LHB CGB1	4.28e-06	6	85	3	MP:0003527
MousePheno	absent extraembryonic coelom	EXOSC1 ARFRP1 PELO	4.28e-06	6	85	3	MP:0011209
MousePheno	small bulbourethral gland	CGB7 LHB CGB1	7.46e-06	7	85	3	MP:0013737
MousePheno	small external male genitalia	CGB7 LHB CGB1	1.19e-05	8	85	3	MP:0009202
MousePheno	abnormal bulbourethral gland morphology	CGB7 LHB CGB1	4.59e-05	12	85	3	MP:0001169
MousePheno	thin endometrium	CGB7 LHB CGB1	9.36e-05	15	85	3	MP:0008258
MousePheno	absent mature ovarian follicles	CGB7 LHB CGB1 TAF4B	9.85e-05	40	85	4	MP:0001132
MousePheno	abnormal Leydig cell differentiation	CGB7 LHB CGB1	1.15e-04	16	85	3	MP:0013602
MousePheno	ovary cyst	CGB7 LHB CGB1 TAF4B	1.71e-04	46	85	4	MP:0002016
MousePheno	small prostate gland	CGB7 LHB CGB1	1.96e-04	19	85	3	MP:0002774
MousePheno	abnormal extraembryonic coelom morphology	EXOSC1 ARFRP1 PELO	2.30e-04	20	85	3	MP:0011200
MousePheno	abnormal external female genitalia morphology	CGB7 LHB CGB1	2.67e-04	21	85	3	MP:0003126
MousePheno	abnormal sex gland secretion	CGB7 LHB CGB1	3.52e-04	23	85	3	MP:0002779
MousePheno	uterus hypoplasia	CGB7 LHB CGB1	3.52e-04	23	85	3	MP:0001121
MousePheno	abnormal tertiary ovarian follicle morphology	CGB7 LHB CGB1 TAF4B	3.93e-04	57	85	4	MP:0009363
Domain	Gonadotropin_bsu_CS	CGB3 CGB7 LHB CGB1	1.11e-08	6	99	4	IPR018245
Domain	Gonadotropin_bsu	CGB3 CGB7 LHB CGB1	2.57e-08	7	99	4	IPR001545
Domain	GLYCO_HORMONE_BETA_2	CGB3 CGB7 LHB CGB1	2.57e-08	7	99	4	PS00689
Domain	GHB	CGB3 CGB7 LHB CGB1	2.57e-08	7	99	4	SM00068
Domain	GLYCO_HORMONE_BETA_1	CGB3 CGB7 LHB CGB1	2.57e-08	7	99	4	PS00261
Domain	DUF2012	NOMO1 NOMO2 NOMO3	5.76e-07	4	99	3	PF09430
Domain	DUF2012	NOMO1 NOMO2 NOMO3	5.76e-07	4	99	3	IPR019008
Domain	Glyco_hormone_CN	CGB3 CGB7 LHB CGB1	9.69e-07	15	99	4	IPR006208
Domain	Cys_knot	CGB3 CGB7 LHB CGB1	9.69e-07	15	99	4	PF00007
Domain	-	PDGFRL MYCBP2 ROR2 MDGA2 NECTIN3 PLXNB2 NCR3LG1 NOMO1 NOMO2 PLXNA4 RIMBP2 CD200R1L NOMO3 VCAM1 PLXNB1	2.07e-06	663	99	15	2.60.40.10
Domain	Ig-like_fold	PDGFRL MYCBP2 ROR2 MDGA2 NECTIN3 PLXNB2 NCR3LG1 NOMO1 NOMO2 PLXNA4 RIMBP2 CD200R1L NOMO3 VCAM1 PLXNB1	4.47e-06	706	99	15	IPR013783
Domain	Carb-bd-like_fold	NOMO1 NOMO2 NOMO3	7.94e-06	8	99	3	IPR013784
Domain	Plexin_cytopl	PLXNB2 PLXNA4 PLXNB1	1.19e-05	9	99	3	PF08337
Domain	Plexin_cytoplasmic_RasGAP_dom	PLXNB2 PLXNA4 PLXNB1	1.19e-05	9	99	3	IPR013548
Domain	Plexin	PLXNB2 PLXNA4 PLXNB1	1.19e-05	9	99	3	IPR031148
Domain	-	IL17A CGB3 CGB7 LHB CGB1	2.81e-05	67	99	5	2.10.90.10
Domain	Cystine-knot_cytokine	IL17A CGB3 CGB7 LHB CGB1	2.81e-05	67	99	5	IPR029034
Domain	CarboxyPept_regulatory_dom	NOMO1 NOMO2 NOMO3	3.98e-05	13	99	3	IPR014766
Domain	-	NOMO1 NOMO2 NOMO3	3.98e-05	13	99	3	2.60.40.1120
Domain	CarboxyPept-like_regulatory	NOMO1 NOMO2 NOMO3	9.31e-05	17	99	3	IPR008969
Domain	REJ	PKD1L1 PKD1L2	1.66e-04	4	99	2	PS51111
Domain	REJ_dom	PKD1L1 PKD1L2	1.66e-04	4	99	2	IPR014010
Domain	IPT	PLXNB2 PLXNA4 PLXNB1	3.85e-04	27	99	3	SM00429
Domain	PKD/REJ-like	PKD1L1 PKD1L2	4.11e-04	6	99	2	IPR002859
Domain	REJ	PKD1L1 PKD1L2	4.11e-04	6	99	2	PF02010
Domain	TIG	PLXNB2 PLXNA4 PLXNB1	5.83e-04	31	99	3	PF01833
Domain	Sema	PLXNB2 PLXNA4 PLXNB1	5.83e-04	31	99	3	SM00630
Domain	Semap_dom	PLXNB2 PLXNA4 PLXNB1	5.83e-04	31	99	3	IPR001627
Domain	Sema	PLXNB2 PLXNA4 PLXNB1	5.83e-04	31	99	3	PF01403
Domain	SEMA	PLXNB2 PLXNA4 PLXNB1	5.83e-04	31	99	3	PS51004
Domain	PSI	PLXNB2 PLXNA4 PLXNB1	6.41e-04	32	99	3	PF01437
Domain	IPT	PLXNB2 PLXNA4 PLXNB1	6.41e-04	32	99	3	IPR002909
Domain	Plexin_repeat	PLXNB2 PLXNA4 PLXNB1	6.41e-04	32	99	3	IPR002165
Domain	PKD_channel	PKD1L1 PKD1L2	1.48e-03	11	99	2	PF08016
Domain	PKD1_2_channel	PKD1L1 PKD1L2	1.48e-03	11	99	2	IPR013122
Domain	PSI	PLXNB2 PLXNA4 PLXNB1	1.63e-03	44	99	3	IPR016201
Domain	PSI	PLXNB2 PLXNA4 PLXNB1	1.86e-03	46	99	3	SM00423
Domain	Ig_E-set	MYCBP2 PLXNB2 PLXNA4 PLXNB1	2.28e-03	104	99	4	IPR014756
Domain	DAGKc	CERK DGKI	2.43e-03	14	99	2	SM00046
Domain	Diacylglycerol_kinase_cat_dom	CERK DGKI	2.79e-03	15	99	2	IPR001206
Domain	L30e-like	PELO SECISBP2	2.79e-03	15	99	2	IPR029064
Domain	DAGK_cat	CERK DGKI	2.79e-03	15	99	2	PF00781
Domain	DAGK	CERK DGKI	2.79e-03	15	99	2	PS50146
Domain	-	PELO SECISBP2	2.79e-03	15	99	2	3.30.1330.30
Domain	NAD/diacylglycerol_kinase	CERK DGKI	3.59e-03	17	99	2	IPR016064
Domain	LH2	PKD1L1 PKD1L2	4.03e-03	18	99	2	SM00308
Domain	RasGAP_dom	PLXNB2 PLXNB1	4.03e-03	18	99	2	IPR001936
Domain	RCC1	MYCBP2 NEK9	4.97e-03	20	99	2	PF00415
Pathway	REACTOME_MINERALOCORTICOID_BIOSYNTHESIS	CGB7 LHB CGB1	3.87e-05	12	81	3	MM14749
Pathway	REACTOME_GLYCOPROTEIN_HORMONES	CGB7 LHB CGB1	5.01e-05	13	81	3	MM14830
Pathway	REACTOME_REACTIONS_SPECIFIC_TO_THE_COMPLEX_N_GLYCAN_SYNTHESIS_PATHWAY	CGB7 LHB CGB1	5.01e-05	13	81	3	MM15701
Pathway	REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS	CGB7 LHB CGB1	7.91e-05	15	81	3	MM14832
Pathway	REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS	CGB7 LHB CGB1	7.91e-05	15	81	3	MM14972
Pathway	REACTOME_ANDROGEN_BIOSYNTHESIS	CGB7 LHB CGB1	7.91e-05	15	81	3	MM14739
Pathway	REACTOME_METABOLISM_OF_LIPIDS	HEXA CERK MBTPS1 PECR ACAA1 CGB7 PLA2G4E ECHS1 FAAH LHB CGB1 PI4KA	2.06e-04	620	81	12	MM15193
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_THE_AP_2_TFAP2_FAMILY_OF_TRANSCRIPTION_FACTORS	CGB7 LHB CGB1	4.32e-04	26	81	3	MM15502
Pubmed	Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone.	CGB3 CGB7 LHB CGB1	2.33e-09	7	101	4	6690982
Pubmed	Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.	NOMO1 NOMO2 NOMO3	2.38e-08	3	101	3	36011023
Pubmed	Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection.	CGB3 CGB7 LHB	2.38e-08	3	101	3	11861891
Pubmed	Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.	NOMO1 NOMO2 NOMO3	2.38e-08	3	101	3	25576386
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	KIF23 HIVEP1 DDX56 NUP214 XPO1 ECHS1 LANCL2 NEK9 PRDM2 NOMO1 NMD3 SLC25A3 LONP1 WDR6 PI4KA RAB3GAP2 PCBP1 ENO1 HNRNPLL	2.56e-08	1425	101	19	30948266
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	HIVEP1 RGPD8 MYCBP2 NUP214 NEK9 SFMBT2 PRDM2 WDR6 RAB3GAP2 NAV1 NPAT	4.00e-08	418	101	11	34709266
Pubmed	Nucleolar proteome dynamics.	POP4 EXOSC1 EXOSC8 DDX56 XPO1 NMD3 NOSIP PELO PRPF3 PCBP1 HNRNPLL	4.10e-08	419	101	11	15635413
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	HEXA PECR XPO1 NOMO1 NOMO2 PCBP1 PCBP2 ENO1 HNRNPLL NOMO3	6.81e-08	344	101	10	30333137
Pubmed	Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.	NOMO1 NOMO2 NOMO3	9.49e-08	4	101	3	31833031
Pubmed	A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.	NOMO1 NOMO2 NOMO3	9.49e-08	4	101	3	9267806
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	HIVEP1 RGPD8 EXOSC1 NOSIP DDX11 PELO NOMO2 PI4KA NAV1 SECISBP2 PCBP2 FOXK1	1.48e-07	588	101	12	38580884
Pubmed	Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit genes.	CGB3 CGB7 LHB	2.37e-07	5	101	3	2424697
Pubmed	Androgen-responsive microRNAs in mouse Sertoli cells.	CGB7 LHB CGB1	2.37e-07	5	101	3	22911753
Pubmed	The pleiotropic effects of excessive luteinizing hormone secretion in transgenic mice.	CGB7 LHB CGB1	2.37e-07	5	101	3	17710732
Pubmed	Stress levels of glucocorticoids inhibit LHβ-subunit gene expression in gonadotrope cells.	CGB7 LHB CGB1	2.37e-07	5	101	3	22851703
Pubmed	Luteinizing hormone induction of ovarian tumors: oligogenic differences between mouse strains dictates tumor disposition.	CGB7 LHB CGB1	2.37e-07	5	101	3	10618427
Pubmed	Ovulatory surges of human CG prevent hormone-induced granulosa cell tumor formation leading to the identification of tumor-associated changes in the transcriptome.	CGB7 LHB CGB1	2.37e-07	5	101	3	12040011
Pubmed	An Otx-related homeodomain protein binds an LHbeta promoter element important for activation during gonadotrope maturation.	CGB7 LHB CGB1	2.37e-07	5	101	3	12040015
Pubmed	Transgenic mice with chronically elevated luteinizing hormone are infertile due to anovulation, defects in uterine receptivity, and midgestation pregnancy failure.	CGB7 LHB CGB1	2.37e-07	5	101	3	10342846
Pubmed	Cloning of the mouse gonadotropin beta-subunit-encoding genes, II. Structure of the luteinizing hormone beta-subunit-encoding genes.	CGB7 LHB CGB1	2.37e-07	5	101	3	8543188
Pubmed	Isolation and characterization of the human chorionic gonadotropin beta subunit (CG beta) gene cluster: regulation of transcriptionally active CG beta gene by cyclic AMP.	CGB3 CGB7 CGB1	2.37e-07	5	101	3	2468994
Pubmed	Luteinizing hormone beta promoter stimulation by adenylyl cyclase and cooperation with gonadotropin-releasing hormone 1 in transgenic mice and LBetaT2 Cells.	CGB7 LHB CGB1	2.37e-07	5	101	3	17699734
Pubmed	Sulfation of LH does not affect intracellular trafficking.	CGB7 LHB CGB1	2.37e-07	5	101	3	19647136
Pubmed	Expression of the beta subunit of chorionic gonadotropin in transgenic mice.	CGB7 LHB CGB1	2.37e-07	5	101	3	7508931
Pubmed	Targeted overexpression of luteinizing hormone causes ovary-dependent functional adenomas restricted to cells of the Pit-1 lineage.	CGB7 LHB CGB1	2.37e-07	5	101	3	12960102
Pubmed	The role of luteinizing hormone-beta gene polymorphism in the onset and progression of puberty in healthy boys.	CGB7 LHB CGB1	2.37e-07	5	101	3	8784083
Pubmed	An i-motif-regulated enhancer, eRNA and adjacent lncRNA affect Lhb expression through distinct mechanisms in a sex-specific context.	CGB7 LHB CGB1	2.37e-07	5	101	3	39158745
Pubmed	Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone.	CGB7 LHB CGB1	2.37e-07	5	101	3	1727547
Pubmed	Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors.	CGB7 LHB CGB1	2.37e-07	5	101	3	7877975
Pubmed	Targeted disruption of luteinizing hormone beta-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility.	CGB7 LHB CGB1	2.37e-07	5	101	3	15569941
Pubmed	Elevated luteinizing hormone in prepubertal transgenic mice causes hyperandrogenemia, precocious puberty, and substantial ovarian pathology.	CGB7 LHB CGB1	2.37e-07	5	101	3	9231809
Pubmed	SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability.	CGB7 LHB CGB1 PLXNA4	3.86e-07	21	101	4	38062045
Pubmed	Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition.	CGB7 LHB CGB1	4.72e-07	6	101	3	14871891
Pubmed	Distinct mechanisms involving diverse histone deacetylases repress expression of the two gonadotropin beta-subunit genes in immature gonadotropes, and their actions are overcome by gonadotropin-releasing hormone.	CGB7 LHB CGB1	4.72e-07	6	101	3	17371839
Pubmed	Luteinizing hormone promotes gonadal tumorigenesis in inhibin-deficient mice.	CGB7 LHB CGB1	4.72e-07	6	101	3	18657590
Pubmed	The beta chorionic gonadotropin-beta luteinizing gene cluster maps to human chromosome 19.	CGB3 CGB7 CGB1	4.72e-07	6	101	3	6204923
Pubmed	Effect of Soluble Adenylyl Cyclase (ADCY10) Inhibitors on the LH-Stimulated cAMP Synthesis in Mltc-1 Leydig Cell Line.	CGB7 LHB CGB1	4.72e-07	6	101	3	33924969
Pubmed	AMP-activated protein kinase is a key intermediary in GnRH-stimulated LHβ gene transcription.	CGB7 LHB CGB1	4.72e-07	6	101	3	23518923
Pubmed	Dependence of uterine cyclooxygenase2 expression on luteinizing hormone signaling.	CGB7 LHB CGB1	4.72e-07	6	101	3	15814897
Pubmed	Ablation of GalNAc-4-sulfotransferase-1 enhances reproduction by altering the carbohydrate structures of luteinizing hormone in mice.	CGB7 LHB CGB1	4.72e-07	6	101	3	18431515
Pubmed	Differential activation of the luteinizing hormone beta-subunit promoter by activin and gonadotropin-releasing hormone: a role for the mitogen-activated protein kinase signaling pathway in LbetaT2 gonadotrophs.	CGB7 LHB CGB1	4.72e-07	6	101	3	13679314
Pubmed	The role of endocannabinoids in the regulation of luteinizing hormone and prolactin release. Differences between the effects of AEA and 2AG.	CGB7 LHB CGB1	4.72e-07	6	101	3	18308464
Pubmed	CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice.	CGB7 LHB CGB1	4.72e-07	6	101	3	22508984
Pubmed	A new role for wilms tumor protein 1: differential activities of + KTS and -KTS variants to regulate LHβ transcription.	CGB7 LHB CGB1	4.72e-07	6	101	3	25617744
Pubmed	A map of the hCG beta-LH beta gene cluster.	CGB3 CGB7 CGB1	4.72e-07	6	101	3	2422163
Pubmed	The beta subunit of human chorionic gonadotropin is encoded by multiple genes.	CGB3 CGB7 CGB1	4.72e-07	6	101	3	6194155
Pubmed	Development of a methodology for and assessment of pulsatile luteinizing hormone secretion in juvenile and adult male mice.	CGB7 LHB CGB1	4.72e-07	6	101	3	24092638
Pubmed	Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo.	CGB3 CGB7 CGB1	4.72e-07	6	101	3	1371113
Pubmed	Free fatty acids induce Lhb mRNA but suppress Fshb mRNA in pituitary LβT2 gonadotropes and diet-induced obesity reduces FSH levels in male mice and disrupts the proestrous LH/FSH surge in female mice.	CGB7 LHB CGB1	4.72e-07	6	101	3	23525221
Pubmed	The role of amino acid neurotransmitters in the regulation of pituitary gonadotropin release in fish.	CGB7 LHB CGB1	4.72e-07	6	101	3	10949077
Pubmed	Secretoneurin stimulates the production and release of luteinizing hormone in mouse L{beta}T2 gonadotropin cells.	CGB7 LHB CGB1	4.72e-07	6	101	3	21521715
Pubmed	Functional analysis of LHbeta knockout mice.	CGB7 LHB CGB1	4.72e-07	6	101	3	17350160
Pubmed	Increases in luteinizing hormone are associated with declines in cognitive performance.	CGB7 LHB CGB1	4.72e-07	6	101	3	17376589
Pubmed	Development of leydig cells in the insulin-like growth factor-I (igf-I) knockout mouse: effects of igf-I replacement and gonadotropic stimulation.	CGB7 LHB CGB1	4.72e-07	6	101	3	14585811
Pubmed	The lack of estrogen and excess luteinizing hormone are responsible for the female ArKO mouse phenotype.	CGB7 LHB CGB1	4.72e-07	6	101	3	20546829
Pubmed	Maximal activity of the luteinizing hormone beta-subunit gene requires beta-catenin.	CGB7 LHB CGB1	4.72e-07	6	101	3	17244763
Pubmed	The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of luteinizing hormone.	CGB3 CGB7 CGB1	4.72e-07	6	101	3	6319099
Pubmed	Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice.	CGB7 LHB CGB1	4.72e-07	6	101	3	17569755
Pubmed	The calcium component of gonadotropin-releasing hormone-stimulated luteinizing hormone subunit gene transcription is mediated by calcium/calmodulin-dependent protein kinase type II.	CGB7 LHB CGB1	4.72e-07	6	101	3	12746302
Pubmed	Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRH.	CGB7 LHB CGB1	4.72e-07	6	101	3	12193554
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	RGPD8 MYCBP2 XPO1 NEK9 CDKAL1 NOMO1 DDX11 SLC25A3 PELO NOMO2 WDR6 DNA2 PCBP1 PCBP2 ENO1 NOMO3	6.86e-07	1257	101	16	37317656
Pubmed	Early growth response protein 1 binds to the luteinizing hormone-beta promoter and mediates gonadotropin-releasing hormone-stimulated gene expression.	CGB7 LHB CGB1	8.25e-07	7	101	3	10319325
Pubmed	Expression of the pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1R) potentiates the effects of GnRH on gonadotropin subunit gene expression.	CGB7 LHB CGB1	8.25e-07	7	101	3	21658369
Pubmed	Disruption of the single copy gonadotropin-releasing hormone receptor in mice by gene trap: severe reduction of reproductive organs and functions in developing and adult mice.	CGB7 LHB CGB1	8.25e-07	7	101	3	20068010
Pubmed	Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice.	CGB7 LHB CGB1	8.25e-07	7	101	3	12748296
Pubmed	Biphasic Roles of Clock Genes and Bone Morphogenetic Proteins in Gonadotropin Expression by Mouse Gonadotrope Cells.	CGB7 LHB CGB1	8.25e-07	7	101	3	34681844
Pubmed	Ovulation involves the luteinizing hormone-dependent activation of G(q/11) in granulosa cells.	CGB7 LHB CGB1	8.25e-07	7	101	3	23836924
Pubmed	Cyclic GMP signaling is involved in the luteinizing hormone-dependent meiotic maturation of mouse oocytes.	CGB7 LHB CGB1	8.25e-07	7	101	3	19474061
Pubmed	Assignment of the genes for the alpha and beta subunits of thyrotropin to different mouse chromosomes.	CGB7 LHB CGB1	8.25e-07	7	101	3	6582507
Pubmed	FOXO1 transcription factor inhibits luteinizing hormone β gene expression in pituitary gonadotrope cells.	CGB7 LHB CGB1	8.25e-07	7	101	3	22865884
Pubmed	Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2.	CGB7 LHB CGB1	8.25e-07	7	101	3	17299135
Pubmed	Anterior pituitary development: short tales from dwarf mice.	CGB7 LHB CGB1	8.25e-07	7	101	3	1505020
Pubmed	Stress rapidly suppresses in vivo LH pulses and increases activation of RFRP-3 neurons in male mice.	CGB7 LHB CGB1	8.25e-07	7	101	3	30382693
Pubmed	Embryonic expression of the luteinizing hormone beta gene appears to be coupled to the transient appearance of p8, a high mobility group-related transcription factor.	CGB7 LHB CGB1	8.25e-07	7	101	3	12429736
Pubmed	PPARγ co-activator-1α co-activates steroidogenic factor 1 to stimulate the synthesis of luteinizing hormone and aldosterone.	CGB7 LHB CGB1	8.25e-07	7	101	3	21108604
Pubmed	The orphan nuclear receptors COUP-TFI and COUP-TFII regulate expression of the gonadotropin LHβ gene.	CGB7 LHB CGB1	8.25e-07	7	101	3	20797425
Pubmed	Mutual Effects of Orexin and Bone Morphogenetic Proteins on Gonadotropin Expression by Mouse Gonadotrope Cells.	CGB7 LHB CGB1	8.25e-07	7	101	3	36077179
Pubmed	Absent Progesterone Signaling in Kisspeptin Neurons Disrupts the LH Surge and Impairs Fertility in Female Mice.	CGB7 LHB CGB1	8.25e-07	7	101	3	26076042
Pubmed	Icam5 Expression Exhibits Sex Differences in the Neonatal Pituitary and Is Regulated by Estradiol and Bisphenol A.	CGB7 LHB CGB1	8.25e-07	7	101	3	26789235
Pubmed	Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function in mice.	CGB7 LHB CGB1	8.25e-07	7	101	3	24706813
Pubmed	Reference intervals for serum testosterone, SHBG, LH and FSH in males from the NORIP project.	CGB7 LHB CGB1	8.25e-07	7	101	3	19929279
Pubmed	Regulation of LH/FSH expression by secretoglobin 3A2 in the mouse pituitary gland.	CGB7 LHB CGB1	8.25e-07	7	101	3	24514953
Pubmed	Evidence for cross-talk between the LH receptor and LH during implantation in mice.	CGB7 LHB CGB1	8.25e-07	7	101	3	23464498
Pubmed	A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis.	CGB7 LHB CGB1	8.25e-07	7	101	3	9501026
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	KIF23 HIVEP1 MYCBP2 PKD1L1 PKD1L2 SFMBT2 ASXL3 PCBP1 ENO1	1.14e-06	361	101	9	26167880
Pubmed	The expression of plexins during mouse embryogenesis.	PLXNB2 PLXNA4 PLXNB1	1.32e-06	8	101	3	15661641
Pubmed	Transforming growth factor-beta1 null mutation causes infertility in male mice associated with testosterone deficiency and sexual dysfunction.	CGB7 LHB CGB1	1.32e-06	8	101	3	17478551
Pubmed	Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone.	CGB7 LHB CGB1	1.32e-06	8	101	3	26522847
Pubmed	Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.	NOMO1 NOMO2 NOMO3	1.32e-06	8	101	3	15257293
Pubmed	LIM homeodomain transcription factor Isl-1 enhances follicle stimulating hormone-beta and luteinizing hormone-beta gene expression and mediates the activation of leptin on gonadotropin synthesis.	CGB7 LHB CGB1	1.32e-06	8	101	3	20702576
Pubmed	The polycystic ovary syndrome-associated gene Yap1 is regulated by gonadotropins and sex steroid hormones in hyperandrogenism-induced oligo-ovulation in mouse.	CGB7 LHB CGB1	1.32e-06	8	101	3	28961951
Pubmed	Gonadotrope-specific deletion of Dicer results in severely suppressed gonadotropins and fertility defects.	CGB7 LHB CGB1	1.32e-06	8	101	3	25525274
Pubmed	Gonadotrope and thyrotrope development in the human and mouse anterior pituitary gland.	CGB7 LHB CGB1	1.32e-06	8	101	3	16806148
Pubmed	The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus.	CGB7 LHB CGB1	1.32e-06	8	101	3	7659091
Pubmed	Defining the membrane proteome of NK cells.	HEXA ACAA1 MYCBP2 DDX56 XPO1 CDKAL1 NOMO1 NMD3 SLC25A3 LONP1 PI4KA PCBP1 PCBP2 ENO1 HNRNPLL	1.42e-06	1168	101	15	19946888
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	HEXA KIF23 RGPD8 MYCBP2 NUP214 NECTIN3 CDKAL1 NOMO2 WDR6 RAB3GAP2 NAV1 SECISBP2	1.51e-06	733	101	12	34672954
Pubmed	Pituitary homeobox 1 (Ptx1) is differentially expressed during pituitary development.	CGB7 LHB CGB1	1.97e-06	9	101	3	10067870
Pubmed	Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism.	CGB7 LHB CGB1	1.97e-06	9	101	3	17959774
Pubmed	Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2.	CGB7 LHB CGB1	1.97e-06	9	101	3	16537498
Pubmed	Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin.	CGB7 LHB CGB1	1.97e-06	9	101	3	8389457
Interaction	METTL22 interactions	EXOSC1 EXOSC8 XPO1 FOXK1	7.85e-06	26	100	4	int:METTL22
Cytoband	19q13.32	CGB3 CGB7 LHB CGB1 TRAPPC6A	6.66e-07	74	101	5	19q13.32
Cytoband	13q13.1	EXOSC8 ZAR1L	3.68e-04	13	101	2	13q13.1
Cytoband	19p12	ZNF737 ZNF723 ZNF681	1.06e-03	90	101	3	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF737 ZNF723 ZNF681	2.52e-03	122	101	3	chr19p12
Cytoband	16p12.3	NOMO2 PDILT	2.57e-03	34	101	2	16p12.3
Cytoband	10q24	EXOSC1 LGI1	2.72e-03	35	101	2	10q24
GeneFamily	Plexins	PLXNB2 PLXNA4 PLXNB1	2.73e-06	9	59	3	683
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	PDGFRL ROR2 MDGA2 NECTIN3 VCAM1	1.79e-04	161	59	5	593
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	NECTIN3 CD200R1L VCAM1	2.99e-04	40	59	3	592
GeneFamily	Exosome complex	EXOSC1 EXOSC8	6.77e-04	12	59	2	817
GeneFamily	Immunoglobulin like domain containing	PDGFRL MDGA2 NECTIN3 VCAM1	3.62e-03	193	59	4	594
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid-Lymphoid_DC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RGPD8 ROR2 GRIN1 CABYR SLC8A3 CD40 NAV1 VCAM1	4.59e-09	167	101	8	8b223333c0c7a85b5a1af6f2f5b12ee0d94357f6
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	MYCBP2 XPO1 CDKAL1 NOMO2 DNA2 VCAM1	4.21e-06	186	101	6	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	MBTPS1 MYCBP2 XPO1 CDKAL1 NOMO2 DNA2	4.91e-06	191	101	6	9454f642c3621370fa23640b631301346b300950
ToppCell	Bronchial-10x5prime-Stromal-Mesofibroblastic-Mesothelia\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	OR4N2 ROR2 MDGA2 PLXNA4 RIMBP2 VCAM1	5.86e-06	197	101	6	26888af95a7cc082a1f1218af35b1f07cb9436ed
ToppCell	Bronchial-10x5prime-Stromal-Mesofibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	OR4N2 ROR2 MDGA2 PLXNA4 RIMBP2 VCAM1	5.86e-06	197	101	6	438de7f0d35d81d5f5e41dcef7b2c54b6da03df4
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_4\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	NEK9 SFMBT2 MARCHF3 GPC2 TAF4B	1.37e-05	134	101	5	9e12aac8f42790c2f104dfd61c87aa99fc7925f1
Disease	lutropin subunit beta measurement	CGB3 LHB	3.27e-05	3	98	2	EFO_0801773
Disease	cutaneous lupus erythematosus (is_marker_for)	IL17A CD40	6.52e-05	4	98	2	DOID:0050169 (is_marker_for)
Disease	luteinizing hormone measurement	CGB3 LHB	3.87e-04	9	98	2	EFO_0007002
Disease	Multiple Sclerosis	IL17A CD40 VCAM1	4.56e-04	45	98	3	C0026769
Disease	Multiple Sclerosis, Acute Fulminating	IL17A CD40 VCAM1	4.56e-04	45	98	3	C0751324
Disease	Enzymopathy	KIF23 ENO1	5.89e-04	11	98	2	C0520572
Disease	Parkinson disease	MYCBP2 WNT9A MDGA2 DDX11 ASXL3 MARCHF3	7.20e-04	321	98	6	MONDO_0005180
Disease	eye colour measurement	MBTPS1 MYCBP2 ROR2 MDGA2 NECTIN3	8.18e-04	218	98	5	EFO_0009764
Disease	human Chorionic Gonadotropin measurement	CGB3 LHB	8.32e-04	13	98	2	EFO_0008156
Disease	Hypogonadotropic hypogonadism	CGB3 LHB	1.11e-03	15	98	2	C0271623
Disease	Primary hypogonadism	CGB3 LHB	1.11e-03	15	98	2	C0948896
Disease	Hypogonadism, Isolated Hypogonadotropic	CGB3 LHB	1.11e-03	15	98	2	C3489396
Disease	Hypogonadism	CGB3 LHB	1.27e-03	16	98	2	C0020619
Disease	allergic rhinitis (is_marker_for)	IL17A CD40	1.44e-03	17	98	2	DOID:4481 (is_marker_for)
Disease	diabetes mellitus	MYCBP2 NCR3LG1 CDKAL1	1.52e-03	68	98	3	EFO_0000400
Disease	Alcoholic Intoxication, Chronic	IL17A NTSR1 GRIN1 ECHS1 LHB	2.03e-03	268	98	5	C0001973
Disease	nose morphology measurement, mouth morphology measurement	CD40 DNA2	2.20e-03	21	98	2	EFO_0007843, EFO_0007955
Disease	metabolite measurement	PECR SRR PKD1L2 CDKAL1 FAAH RIMBP2 LGI1	2.67e-03	560	98	7	EFO_0004725
Disease	Malignant neoplasm of breast	NUP214 MOSPD1 FAAH SLC8A3 ARFRP1 CD40 HRG GPC2 ENO1 PLXNB1	3.03e-03	1074	98	10	C0006142

Protein segments in the cluster

Peptide	Gene	Start	Entry
KETSVKTECVAGVTP	ANKRD30B	366	Q9BXX2
KTECVAGVTPNKTEV	ANKRD30B	371	Q9BXX2
CVALSKNGVSSVPEV	ARFGEF1	486	Q9Y6D6
IGTTHPSIVDCVLKV	ARMH1	216	Q6PIY5
LAVEKEGCPVCITVN	CGB1	66	A6NKQ9
AAPLVCSGKVLEVQV	CABYR	221	O75952
VPVSVCSTAISGAIK	ASXL3	1236	Q9C0F0
VSVEDAVPTIFCGKI	RAI2	441	Q9Y5P3
LVTKEDVLGCNVSPV	NOMO3	241	P69849
SPCGKIAVAVLEEIT	RGPD8	1486	O14715
TTVICGVKAEFAAPS	EXOSC8	56	Q96B26
KVSVSPVVHVRGLCE	HNRNPLL	71	Q8WVV9
PSGAVVTLECVEKLI	NOSIP	241	Q9Y314
LVKCLSSEETVGAVV	NPAT	786	Q14207
QICLVDPVSGSVKTV	RAB3GAP2	521	Q9H2M9
LVTKEDVLGCNVSPV	NOMO2	241	Q5JPE7
ITIAGVPQSVTECVK	PCBP1	146	Q15365
ECSKPEQLVVTFVAG	SLC25A3	256	Q00325
RPSEIVIGQCKVIAT	HRG	96	P04196
VDVPKALIIVAVQCG	NEK9	526	Q8TD19
CSIAKFPEDGVVITQ	MBTPS1	791	Q14703
GLVCTPTIHTATVKV	NTSR1	221	P30989
NVVSEALKVPVSEGC	GPC2	236	Q8N158
LAVEKEGCPVCITVN	LHB	36	P01229
RCEVVVTPLKAQGTV	NCR3LG1	121	Q68D85
PGTVCESAIKEVVNA	LANCL2	216	Q9NS86
CVIATDAEVLGAPVK	DDX56	311	Q9NY93
GKTATGTICIEVPDI	DSG4	476	Q86SJ6
LAVEKEGCPVCITVN	CGB7	36	P0DN87
AGLVSKICPVETLVE	ECHS1	206	P30084
ITAVCKAVTGKPAAQ	CD200R1L	156	Q6Q8B3
GEKPCTVTVSDVQLL	PLXNA4	1186	Q9HCM2
GVPVKVLDCDTISQA	PLXNB1	1766	O43157
EDVRVTLNGVPCKVT	PLXNB2	926	O15031
VPQVIKLACTDTFVV	OR4N2	181	Q8NGD1
KRIGVPEEVSSVVCF	PECR	231	Q9BY49
LVTKEDVLGCNVSPV	NOMO1	241	Q15155
AVCDLGISVVGKPFT	OPN5	76	Q6U736
VVVDAAGAVKPQCCV	MOSPD1	61	Q9UJG1
CLKAGLTVDPVIVEA	PI4KA	576	P42356
ETVKVCATLPSTVAV	NUP214	181	P35658
AAKRAGVTCIVLPAE	LONP1	901	P36776
SQLLPDVGAIVTCKV	EXOSC1	61	Q9Y3B2
VFVVGVVCGDPVTKV	DDX11	926	Q96FC9
EKILVSVGCTCVTPI	IL17A	136	Q16552
IGREVKISCQVEAVP	MDGA2	351	Q7Z553
NVGDCVLDKVFPVAT	PKD1L2	1496	Q7Z442
ITIAGIPQSIIECVK	PCBP2	146	Q15366
KCDANILETTVVIPG	PLA2G4E	621	Q3MJ16
ILGVSLAVCKAGAVE	ENO1	111	P06733
EKVVTSEALCGVPVL	ARFRP1	116	Q13795
LAVEKEGCPVCITVN	CGB3	36	P0DN86
PVSKILCQVEDGTVV	DGKI	481	O75912
VPGCEGVALVVAQTK	FCGBP	351	Q9Y6R7
EKVPGITIATDIICG	CDKAL1	351	Q5VV42
GADACSVPVSEIIAV	CERK	46	Q8TCT0
AKLETVVCTGSVPVD	FNIP1	676	Q8TF40
SAPVVVTRVCEVGPK	FOXK1	656	P85037
APVVKTVEDCGSLVN	MARCHF3	21	Q86UD3
GVPAECDSVVVHVLK	FAAH	161	O00519
IFVKAGCSPSDIGII	DNA2	926	P51530
GKGSKVQPCTVVVTV	PKD1L1	1271	Q8TDX9
DTFVVPCVVASGDIK	CFAP74	1196	Q9C0B2
SEPTVVTAALNCVGK	PRPF3	26	O43395
ISATEIAKLGPVCVS	PRDM2	706	Q13029
VEVARPVDKAICGLT	KIF23	436	Q02241
EKNVLVVSVVTPGCN	HEXA	91	P06865
STCGPKEEVTLRVVV	NAV1	1411	Q8NEY1
EPISCKGVVESAALV	PDILT	131	Q8N807
ALGAVTKAPVSVCVE	TAF4B	41	Q92750
QCTLLVGKDVVVAPS	RIMBP2	381	O15034
TFTPVIEDIGKVLVC	VCAM1	181	P19320
IPTIEDTGKALVCQA	VCAM1	471	P19320
KGCFQAEIVPVTTTV	ACAA1	216	P09110
ILVEPGCQAEVTKTG	OPLAH	701	O14841
VIPKLNCVFTVETDG	POP4	176	O95707
VVSVGAVPVLSKECA	SECISBP2	476	Q96T21
AICFSVDKPGIVVVG	MYCBP2	1746	O75592
VVKCILVASPGFVRE	PELO	201	Q9BRX2
VVCLLGVVTKDQPLS	ROR2	536	Q01974
VVVCPVGKRALIVAS	SNUPN	121	O95149
VSPEVKNICIVLSGG	SRR	301	Q9GZT4
QAVVPCRVTVLSAKV	PDGFRL	191	Q15198
VVGLIIKTSSDPTCV	XPO1	106	O14980
TCSKIGPPAVEAAVT	SP2	41	Q02086
VFLGVGVSKPDLITC	ZNF723	41	P0DPD5
NPGELCVASVVSVKG	SFMBT2	421	Q5VUG0
HVGSAATKVFVCPVV	USP29	411	Q9HBJ7
VVACLEISAAPSGKA	WDR6	461	Q9NNW5
TASVAALPVCKFQVV	TRAPPC6A	141	O75865
VFLGIVVSKPDLVTC	ZNF253	41	O75346
LVGVKVIKAGVETTC	WNT9A	201	O14904
VFLGIVVSKPDLITC	ZNF681	41	Q96N22
PICAITASDKILIVG	WDR35	506	Q9P2L0
TGCSKFVVIEPISEL	HIVEP1	1841	P15822
VKQIATGVSDTICEP	CD40	131	P25942
VGVQVSPRVDKAVQC	ZAR1L	91	A6NP61
VFLGIVVSKPDLITC	ZNF737	41	O75373
DNITGTSTVVCKPIV	LGI1	276	O95970
CTIGLKDSVTAVVFV	SLC8A3	781	P57103
TFSVEIVPICKDNVV	NMD3	241	Q96D46
ACDPKIVNIGAVLST	GRIN1	21	Q05586
NETVAAICIAATGKP	NECTIN3	186	Q9NQS3