Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	carbon-oxygen lyase activity	CA9 POLG CA13 DGLUCY POLQ TPI1	2.61e-05	82	142	6	GO:0016835
GeneOntologyMolecularFunction	GTPase binding	RABAC1 OCRL RILPL1 PAK1 PAK2 PAK3 PRKCH PKN1 PKN2 FGD5 KPNB1	5.45e-05	360	142	11	GO:0051020
GeneOntologyMolecularFunction	protein serine kinase activity	KALRN TRPM7 DAPK1 PAK1 PAK2 PAK3 PRKCH PKN1 PKN2 MAPK1 WNK4	5.88e-05	363	142	11	GO:0106310
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	MYLK KALRN TRPM7 DAPK1 PAK1 PAK2 PAK3 PRKCH PKN1 PKN2 MAPK1 WNK4	8.43e-05	446	142	12	GO:0004674
GeneOntologyMolecularFunction	calcium ion binding	SGCA PCDHGA4 CDHR3 SPTA1 SPTAN1 FKBP9 ACTN4 ACTN3 STAB1 CAPN8 CELSR1 HMCN2 LOXL2 TLL2 AGRN NIN	8.72e-05	749	142	16	GO:0005509
GeneOntologyMolecularFunction	small GTPase binding	OCRL RILPL1 PAK1 PAK2 PAK3 PRKCH PKN1 PKN2 FGD5 KPNB1	1.02e-04	321	142	10	GO:0031267
GeneOntologyMolecularFunction	diacylglycerol-dependent serine/threonine kinase activity	PRKCH PKN1 PKN2	1.84e-04	16	142	3	GO:0004697
GeneOntologyMolecularFunction	metalloendopeptidase activity	SPG7 IDE ADAMTS5 ECE1 TLL2 ADAMTS14	2.19e-04	120	142	6	GO:0004222
GeneOntologyMolecularFunction	L27 domain binding	LIN7C LIN7A	2.98e-04	4	142	2	GO:0097016
GeneOntologyMolecularFunction	structural constituent of cytoskeleton	ANK3 SPTA1 SPTAN1 SPTB ACTN4 AGRN	3.37e-04	130	142	6	GO:0005200
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	MYLK KALRN TRPM7 POLG DAPK1 PAPSS1 FAM20B PAK1 PAK2 PAK3 PRKCH PKN1 PKN2 MAPK1 POLQ GDPGP1 WNK4	3.68e-04	938	142	17	GO:0016772
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	MYLK KALRN TRPM7 DAPK1 PAPSS1 FAM20B PAK1 PAK2 PAK3 PRKCH PKN1 PKN2 MAPK1 WNK4	5.41e-04	709	142	14	GO:0016773
GeneOntologyMolecularFunction	metallopeptidase activity	SPG7 IDE ADAMTS5 ECE1 DPEP3 TLL2 ADAMTS14	5.79e-04	200	142	7	GO:0008237
GeneOntologyMolecularFunction	kinase activity	MYLK KALRN TRPM7 DAPK1 PAPSS1 FAM20B PAK1 PAK2 PAK3 PRKCH PKN1 PKN2 MAPK1 WNK4	1.11e-03	764	142	14	GO:0016301
GeneOntologyMolecularFunction	poly(A) binding	PABPN1L TIA1 PABPC3	1.12e-03	29	142	3	GO:0008143
GeneOntologyMolecularFunction	protein kinase activity	MYLK KALRN TRPM7 DAPK1 PAK1 PAK2 PAK3 PRKCH PKN1 PKN2 MAPK1 WNK4	1.22e-03	600	142	12	GO:0004672
GeneOntologyMolecularFunction	5'-deoxyribose-5-phosphate lyase activity	POLG POLQ	1.37e-03	8	142	2	GO:0051575
GeneOntologyCellularComponent	postsynaptic density	SHANK1 LIN7C ANK3 KALRN DAPK1 GRIN2C CSMD2 LIN7A ABHD17C PTPRO MIB1 PAK1 PAK2 PAK3 SCRIB MAPK1	8.42e-08	451	143	16	GO:0014069
GeneOntologyCellularComponent	neuron to neuron synapse	SHANK1 LIN7C ANK3 KALRN BACE1 DAPK1 GRIN2C CSMD2 LIN7A ABHD17C PTPRO MIB1 PAK1 PAK2 PAK3 SCRIB MAPK1	1.14e-07	523	143	17	GO:0098984
GeneOntologyCellularComponent	asymmetric synapse	SHANK1 LIN7C ANK3 KALRN DAPK1 GRIN2C CSMD2 LIN7A ABHD17C PTPRO MIB1 PAK1 PAK2 PAK3 SCRIB MAPK1	1.80e-07	477	143	16	GO:0032279
GeneOntologyCellularComponent	postsynaptic specialization	SHANK1 LIN7C ANK3 KALRN DAPK1 GRIN2C CSMD2 LIN7A ABHD17C PTPRO MIB1 PAK1 PAK2 PAK3 SCRIB MAPK1	3.67e-07	503	143	16	GO:0099572
GeneOntologyCellularComponent	postsynapse	SHANK1 LIN7C ANK3 KALRN SPTAN1 SPTB APBA1 DAPK1 ACTN4 GRIN2C CSMD2 CHRNA2 LIN7A ABHD17C SLC9A5 PTPRO MIB1 PAK1 PAK2 PAK3 SCRIB MAPK1	1.63e-06	1018	143	22	GO:0098794
GeneOntologyCellularComponent	glutamatergic synapse	SHANK1 LIN7C KALRN SPTAN1 SPTB APBA1 DAPK1 GRIN2C CSMD2 ABHD17C EEF2 PTPRO MIB1 PAK1 PAK2 PAK3 SCRIB AGRN	1.22e-05	817	143	18	GO:0098978
GeneOntologyCellularComponent	cell-cell junction	MYLK LIN7C ANK3 SGCA CDHR3 SPTAN1 ACTN4 LIN7A PAK1 PAK2 PRKCH PKN2 SCRIB DNMBP WNK4	1.35e-05	591	143	15	GO:0005911
GeneOntologyCellularComponent	spectrin-associated cytoskeleton	ANK3 SPTA1 SPTB	2.55e-05	9	143	3	GO:0014731
GeneOntologyCellularComponent	spectrin	SPTA1 SPTAN1 SPTB	2.55e-05	9	143	3	GO:0008091
GeneOntologyCellularComponent	postsynaptic density membrane	LIN7C GRIN2C CSMD2 LIN7A ABHD17C PTPRO SCRIB	1.05e-04	157	143	7	GO:0098839
GeneOntologyCellularComponent	postsynaptic membrane	SHANK1 LIN7C ANK3 GRIN2C CSMD2 CHRNA2 LIN7A ABHD17C SLC9A5 PTPRO SCRIB	1.11e-04	405	143	11	GO:0045211
GeneOntologyCellularComponent	anchoring junction	MYLK LIN7C ANK3 SGCA CDHR3 SPTAN1 ACTN4 ACTN3 LIN7A SLC9A5 PAK1 PAK2 PRKCH PKN2 SCRIB MAPK1 DNMBP WNK4	1.23e-04	976	143	18	GO:0070161
GeneOntologyCellularComponent	pseudopodium	ACTN4 ACTN3 MAPK1	2.37e-04	18	143	3	GO:0031143
GeneOntologyCellularComponent	cortical actin cytoskeleton	SPTA1 SPTAN1 SPTB ACTN4 ACTN3	4.48e-04	93	143	5	GO:0030864
GeneOntologyCellularComponent	MPP7-DLG1-LIN7 complex	LIN7C LIN7A	4.58e-04	5	143	2	GO:0097025
GeneOntologyCellularComponent	postsynaptic specialization membrane	LIN7C GRIN2C CSMD2 LIN7A ABHD17C PTPRO SCRIB	4.75e-04	201	143	7	GO:0099634
GeneOntologyCellularComponent	synaptic membrane	SHANK1 LIN7C ANK3 APBA1 GRIN2C CSMD2 CHRNA2 LIN7A ABHD17C SLC9A5 PTPRO SCRIB	6.82e-04	583	143	12	GO:0097060
GeneOntologyCellularComponent	cleavage furrow	MYLK HMCN2 PKN1 PKN2	8.10e-04	61	143	4	GO:0032154
GeneOntologyCellularComponent	cortical cytoskeleton	SPTA1 SPTAN1 SPTB ACTN4 ACTN3	1.95e-03	129	143	5	GO:0030863
GeneOntologyCellularComponent	cell division site	MYLK HMCN2 PKN1 PKN2	2.22e-03	80	143	4	GO:0032153
Domain	Spectrin	KALRN SPTA1 SPTAN1 SPTB ACTN4 ACTN3	1.64e-08	23	143	6	PF00435
Domain	EFhand_Ca_insen	SPTA1 SPTAN1 ACTN4 ACTN3	4.88e-08	6	143	4	PF08726
Domain	EF-hand_Ca_insen	SPTA1 SPTAN1 ACTN4 ACTN3	4.88e-08	6	143	4	IPR014837
Domain	Spectrin_repeat	KALRN SPTA1 SPTAN1 SPTB ACTN4 ACTN3	7.45e-08	29	143	6	IPR002017
Domain	SPEC	KALRN SPTA1 SPTAN1 SPTB ACTN4 ACTN3	1.39e-07	32	143	6	SM00150
Domain	Spectrin/alpha-actinin	KALRN SPTA1 SPTAN1 SPTB ACTN4 ACTN3	1.39e-07	32	143	6	IPR018159
Domain	PAK_BD	PAK1 PAK2 PAK3	8.64e-06	6	143	3	IPR033923
Domain	DNA-dir_DNA_pol_A_CS	POLG POLQ	5.82e-05	2	143	2	IPR019760
Domain	-	PAK1 PAK2 PAK3	9.19e-05	12	143	3	3.90.810.10
Domain	Ser/Thr_kinase_AS	MYLK KALRN DAPK1 PAK1 PAK2 PAK3 PRKCH PKN1 PKN2 MAPK1 WNK4	9.73e-05	357	143	11	IPR008271
Domain	S_TKc	MYLK KALRN DAPK1 PAK1 PAK2 PAK3 PRKCH PKN1 PKN2 MAPK1 WNK4	1.02e-04	359	143	11	SM00220
Domain	PROTEIN_KINASE_ST	MYLK KALRN DAPK1 PAK1 PAK2 PAK3 PRKCH PKN1 PKN2 MAPK1 WNK4	1.10e-04	362	143	11	PS00108
Domain	Pkinase	MYLK KALRN DAPK1 PAK1 PAK2 PAK3 PRKCH PKN1 PKN2 MAPK1 WNK4	1.72e-04	381	143	11	PF00069
Domain	DNA_pol_A	POLG POLQ	1.74e-04	3	143	2	PF00476
Domain	DNA-dir_DNA_pol_A_palm_dom	POLG POLQ	1.74e-04	3	143	2	IPR001098
Domain	DNA_POLYMERASE_A	POLG POLQ	1.74e-04	3	143	2	PS00447
Domain	POLAc	POLG POLQ	1.74e-04	3	143	2	SM00482
Domain	PBD	PAK1 PAK2 PAK3	2.29e-04	16	143	3	SM00285
Domain	Ank_2	SHANK1 ANK3 DAPK1 ANKRD55 GLS ANKDD1A MIB1 ANKRD34A	2.55e-04	215	143	8	PF12796
Domain	PBD	PAK1 PAK2 PAK3	2.76e-04	17	143	3	PF00786
Domain	Fumarylacetoacetase_C-rel	FAHD2B FAHD2A	3.46e-04	4	143	2	IPR011234
Domain	FAA_hydrolase	FAHD2B FAHD2A	3.46e-04	4	143	2	PF01557
Domain	-	FAHD2B FAHD2A	3.46e-04	4	143	2	3.90.850.10
Domain	Ank	SHANK1 ANK3 DAPK1 ANKRD55 GLS ANKDD1A MIB1 ANKRD34A	3.78e-04	228	143	8	PF00023
Domain	CRIB	PAK1 PAK2 PAK3	4.55e-04	20	143	3	PS50108
Domain	CRIB_dom	PAK1 PAK2 PAK3	5.28e-04	21	143	3	IPR000095
Domain	-	PKN1 PKN2	5.73e-04	5	143	2	1.10.287.160
Domain	-	SHANK1 ANK3 DAPK1 ANKRD55 GLS ANKDD1A MIB1 ANKRD34A	6.58e-04	248	143	8	1.25.40.20
Domain	Protein_kinase_ATP_BS	MYLK KALRN DAPK1 PAK1 PAK2 PAK3 PRKCH PKN1 PKN2 MAPK1	6.88e-04	379	143	10	IPR017441
Domain	ACTININ_2	SPTB ACTN4 ACTN3	6.96e-04	23	143	3	PS00020
Domain	ACTININ_1	SPTB ACTN4 ACTN3	6.96e-04	23	143	3	PS00019
Domain	Actinin_actin-bd_CS	SPTB ACTN4 ACTN3	6.96e-04	23	143	3	IPR001589
Domain	ANK	SHANK1 ANK3 DAPK1 ANKRD55 GLS ANKDD1A MIB1 ANKRD34A	7.11e-04	251	143	8	SM00248
Domain	ANK_REPEAT	SHANK1 ANK3 DAPK1 ANKRD55 GLS ANKDD1A MIB1 ANKRD34A	7.49e-04	253	143	8	PS50088
Domain	PDZ	SHANK1 LIN7C APBA1 LIN7A PTPN4 SCRIB	7.62e-04	141	143	6	PF00595
Domain	Ankyrin_rpt-contain_dom	SHANK1 ANK3 DAPK1 ANKRD55 GLS ANKDD1A MIB1 ANKRD34A	7.69e-04	254	143	8	IPR020683
Domain	ANK_REP_REGION	SHANK1 ANK3 DAPK1 ANKRD55 GLS ANKDD1A MIB1 ANKRD34A	7.69e-04	254	143	8	PS50297
Domain	PROTEIN_KINASE_ATP	MYLK KALRN DAPK1 PAK1 PAK2 PAK3 PRKCH PKN1 PKN2 MAPK1 WNK4	8.25e-04	459	143	11	PS00107
Domain	Ankyrin_rpt	SHANK1 ANK3 DAPK1 ANKRD55 GLS ANKDD1A MIB1 ANKRD34A	9.39e-04	262	143	8	IPR002110
Domain	Kinase-like_dom	MYLK KALRN TRPM7 DAPK1 PAK1 PAK2 PAK3 PRKCH PKN1 PKN2 MAPK1 WNK4	9.57e-04	542	143	12	IPR011009
Domain	PDZ	SHANK1 LIN7C APBA1 LIN7A PTPN4 SCRIB	9.81e-04	148	143	6	SM00228
Domain	Laminin_G	COL20A1 TSPEAR CELSR1 AGRN	1.01e-03	58	143	4	IPR001791
Domain	-	SHANK1 LIN7C APBA1 LIN7A PTPN4 SCRIB	1.05e-03	150	143	6	2.30.42.10
Domain	PDZ	SHANK1 LIN7C APBA1 LIN7A PTPN4 SCRIB	1.09e-03	151	143	6	PS50106
Domain	PDZ	SHANK1 LIN7C APBA1 LIN7A PTPN4 SCRIB	1.13e-03	152	143	6	IPR001478
Domain	WASP_C	PAK1 PAK2	1.19e-03	7	143	2	IPR011026
Domain	Hr1	PKN1 PKN2	1.19e-03	7	143	2	SM00742
Domain	EFh	SPTA1 SPTAN1 FKBP9 ACTN4 ACTN3 CAPN8	1.37e-03	158	143	6	SM00054
Domain	Prot_kinase_dom	MYLK KALRN DAPK1 PAK1 PAK2 PAK3 PRKCH PKN1 PKN2 MAPK1 WNK4	1.37e-03	489	143	11	IPR000719
Domain	PROTEIN_KINASE_DOM	MYLK KALRN DAPK1 PAK1 PAK2 PAK3 PRKCH PKN1 PKN2 MAPK1 WNK4	1.47e-03	493	143	11	PS50011
Domain	EGF_LAM_2	STAB1 CELSR1 AGRN	1.53e-03	30	143	3	PS50027
Domain	EGF_LAM_1	STAB1 CELSR1 AGRN	1.53e-03	30	143	3	PS01248
Domain	HR1	PKN1 PKN2	1.58e-03	8	143	2	PF02185
Domain	Death	ANK3 DAPK1 ANKDD1A	2.03e-03	33	143	3	PF00531
Domain	EF_HAND_2	SPTA1 SPTAN1 FKBP9 ACTN4 ACTN3 CAPN8 NIN	2.04e-03	231	143	7	PS50222
Domain	EF_hand_dom	SPTA1 SPTAN1 FKBP9 ACTN4 ACTN3 CAPN8 NIN	2.09e-03	232	143	7	IPR002048
Domain	EGF_Lam	STAB1 CELSR1 AGRN	2.40e-03	35	143	3	SM00180
Domain	Laminin_EGF	STAB1 CELSR1 AGRN	2.40e-03	35	143	3	PF00053
Domain	EGF_CA	STAB1 CELSR1 HMCN2 TLL2 AGRN	2.48e-03	122	143	5	SM00179
Domain	L27_C	LIN7C LIN7A	2.52e-03	10	143	2	IPR014775
Domain	L27	LIN7C LIN7A	2.52e-03	10	143	2	PF02828
Domain	Rap_GAP	GARNL3 RALGAPA2	2.52e-03	10	143	2	PF02145
Domain	EGF-like_Ca-bd_dom	STAB1 CELSR1 HMCN2 TLL2 AGRN	2.66e-03	124	143	5	IPR001881
Domain	Pkinase_C	PRKCH PKN1 PKN2	2.82e-03	37	143	3	IPR017892
Domain	Death_domain	ANK3 DAPK1 ANKDD1A	3.05e-03	38	143	3	IPR000488
Domain	DEATH_DOMAIN	ANK3 DAPK1 ANKDD1A	3.05e-03	38	143	3	PS50017
Domain	Laminin_EGF	STAB1 CELSR1 AGRN	3.05e-03	38	143	3	IPR002049
Domain	Rap_GAP_dom	GARNL3 RALGAPA2	3.06e-03	11	143	2	IPR000331
Domain	BAH	TNRC18 BAHCC1	3.06e-03	11	143	2	PS51038
Domain	BAH_dom	TNRC18 BAHCC1	3.06e-03	11	143	2	IPR001025
Domain	BAH	TNRC18 BAHCC1	3.06e-03	11	143	2	SM00439
Domain	RAPGAP	GARNL3 RALGAPA2	3.06e-03	11	143	2	PS50085
Domain	BAH	TNRC18 BAHCC1	3.06e-03	11	143	2	PF01426
Domain	-	ADAMTS5 ECE1 TLL2 ADAMTS14	3.47e-03	81	143	4	3.40.390.10
Domain	MetalloPept_cat_dom	ADAMTS5 ECE1 TLL2 ADAMTS14	3.47e-03	81	143	4	IPR024079
Domain	Carbonic_anhydrase_a-class_CS	CA9 CA13	3.65e-03	12	143	2	IPR018338
Domain	-	SPTA1 SPTAN1 FKBP9 ACTN4 ACTN3 CAPN8 NIN	4.01e-03	261	143	7	1.10.238.10
Domain	Pkinase_C	PRKCH PKN1 PKN2	4.06e-03	42	143	3	PF00433
Domain	L27	LIN7C LIN7A	4.30e-03	13	143	2	SM00569
Domain	L27	LIN7C LIN7A	4.30e-03	13	143	2	PS51022
Domain	L27_dom	LIN7C LIN7A	4.30e-03	13	143	2	IPR004172
Domain	LamG	TSPEAR CELSR1 AGRN	4.63e-03	44	143	3	SM00282
Domain	-	ANK3 DAPK1 NLRP10 ANKDD1A	5.68e-03	93	143	4	1.10.533.10
Domain	Spectrin_alpha_SH3	SPTA1 SPTAN1	5.73e-03	15	143	2	IPR013315
Domain	Carbonic_anhydrase_a-class	CA9 CA13	5.73e-03	15	143	2	IPR023561
Domain	ALPHA_CA_1	CA9 CA13	5.73e-03	15	143	2	PS00162
Domain	EF-hand-dom_pair	SPTA1 SPTAN1 FKBP9 ACTN4 ACTN3 CAPN8 NIN	6.68e-03	287	143	7	IPR011992
Domain	ZINC_PROTEASE	ADAMTS5 ECE1 TLL2 ADAMTS14	6.83e-03	98	143	4	PS00142
Domain	DEATH-like_dom	ANK3 DAPK1 NLRP10 ANKDD1A	7.07e-03	99	143	4	IPR011029
Domain	Carb_anhydrase	CA9 CA13	7.34e-03	17	143	2	PF00194
Domain	Carb_anhydrase	CA9 CA13	7.34e-03	17	143	2	SM01057
Domain	-	CA9 CA13	7.34e-03	17	143	2	3.10.200.10
Domain	ALPHA_CA_2	CA9 CA13	7.34e-03	17	143	2	PS51144
Domain	Carbonic_anhydrase_a	CA9 CA13	7.34e-03	17	143	2	IPR001148
Pathway	BIOCARTA_AGR_PATHWAY	PAK1 PAK2 PAK3 MAPK1 AGRN	4.17e-06	31	112	5	MM1343
Pathway	BIOCARTA_AGR_PATHWAY	PAK1 PAK2 PAK3 MAPK1 AGRN	5.75e-06	33	112	5	M6220
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_PAKS	MYLK PAK1 PAK2 PAK3	2.04e-05	21	112	4	M27494
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_PAKS	MYLK PAK1 PAK2 PAK3	2.98e-05	23	112	4	MM15222
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	USP17L7 KALRN SPTA1 SPTAN1 SPTB FGF16 ABHD17C PAK1 PAK2 PAK3 MAPK1	4.48e-05	318	112	11	MM15278
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SPTA1 SPTAN1 SPTB	5.63e-05	10	112	3	MM15112
Pathway	REACTOME_RHOJ_GTPASE_CYCLE	OCRL PAK1 PAK2 PAK3 SCRIB	7.34e-05	55	112	5	M41815
Pathway	REACTOME_NEUREXINS_AND_NEUROLIGINS	SHANK1 LIN7C APBA1 GRIN2C LIN7A	8.00e-05	56	112	5	M27616
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	ANK3 SPTA1 SPTAN1 SPTB	1.01e-04	31	112	4	M877
Pathway	REACTOME_CD28_DEPENDENT_VAV1_PATHWAY	PAK1 PAK2 PAK3	1.02e-04	12	112	3	M13618
Pathway	REACTOME_CD28_DEPENDENT_VAV1_PATHWAY	PAK1 PAK2 PAK3	1.02e-04	12	112	3	MM14994
Pathway	REACTOME_ACTIVATION_OF_RAC1	PAK1 PAK2 PAK3	1.32e-04	13	112	3	M6322
Pathway	REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH	SPTA1 SPTAN1 SPTB MAPK1 AGRN	1.41e-04	63	112	5	M11187
Pathway	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	MYLK PAK1 PAK2 PAK3	1.63e-04	35	112	4	M16801
Pathway	REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION	PAK1 PAK2 PAK3	1.67e-04	14	112	3	MM15029
Pathway	REACTOME_L1CAM_INTERACTIONS	SPTA1 SPTAN1 SPTB PAK1 MAPK1	2.03e-04	68	112	5	MM14968
Pathway	REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH	SPTA1 SPTAN1 SPTB MAPK1	2.26e-04	38	112	4	MM14969
Pathway	REACTOME_RHOU_GTPASE_CYCLE	SPTAN1 PAK1 PAK2 PAK3	2.51e-04	39	112	4	MM15607
Pathway	REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION	PAK1 PAK2 PAK3	2.54e-04	16	112	3	M16498
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	KALRN SPTA1 SPTAN1 SPTB FGF16 ABHD17C PAK1 PAK2 PAK3 MAPK1	2.74e-04	327	112	10	M27565
Pathway	REACTOME_RHOU_GTPASE_CYCLE	SPTAN1 PAK1 PAK2 PAK3	2.77e-04	40	112	4	M41816
Pathway	KEGG_REGULATION_OF_ACTIN_CYTOSKELETON	MYLK ACTN4 ACTN3 FGF16 PAK1 PAK2 PAK3 MAPK1	2.95e-04	213	112	8	M18306
Pathway	REACTOME_CD209_DC_SIGN_SIGNALING	PAK1 PAK2 PAK3	3.06e-04	17	112	3	MM15215
Pathway	REACTOME_EPHRIN_SIGNALING	PAK1 PAK2 PAK3	3.65e-04	18	112	3	MM15024
Pathway	REACTOME_ASSEMBLY_AND_CELL_SURFACE_PRESENTATION_OF_NMDA_RECEPTORS	LIN7C APBA1 GRIN2C LIN7A	4.01e-04	44	112	4	M27934
Pathway	REACTOME_L1CAM_INTERACTIONS	ANK3 SPTA1 SPTAN1 SPTB PAK1 MAPK1	4.03e-04	121	112	6	M872
Pathway	REACTOME_EPHRIN_SIGNALING	PAK1 PAK2 PAK3	4.31e-04	19	112	3	M27310
Pathway	SIG_CHEMOTAXIS	MYLK PAK1 PAK2 PAK3	4.38e-04	45	112	4	M5193
Pathway	REACTOME_RAC1_GTPASE_CYCLE	KALRN PAK1 PAK2 PAK3 PKN1 PKN2 FGD5	4.89e-04	175	112	7	MM15599
Pathway	REACTOME_CD209_DC_SIGN_SIGNALING	PAK1 PAK2 PAK3	5.85e-04	21	112	3	M27485
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	MYLK KALRN SPTAN1 OCRL KIF2B PAK1 PAK2 PAK3 PKN1 PKN2 FGD5 SCRIB MAPK1 DNMBP	6.18e-04	649	112	14	MM15690
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	SHANK1 LIN7C APBA1 GRIN2C LIN7A	6.37e-04	87	112	5	M27617
Pathway	REACTOME_RAC1_GTPASE_CYCLE	KALRN PAK1 PAK2 PAK3 PKN1 PKN2 FGD5	6.59e-04	184	112	7	M41809
Pathway	REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE	LIN7C APBA1 LIN7A GLS	7.08e-04	51	112	4	MM14499
Pathway	REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE	LIN7C APBA1 LIN7A GLS	7.08e-04	51	112	4	M4281
Pathway	REACTOME_RHO_GTPASE_CYCLE	KALRN SPTAN1 OCRL PAK1 PAK2 PAK3 PKN1 PKN2 FGD5 SCRIB DNMBP	7.33e-04	439	112	11	MM15595
Pathway	REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE	LIN7C APBA1 LIN7A	7.70e-04	23	112	3	MM14852
Pathway	REACTOME_NEPHRIN_FAMILY_INTERACTIONS	SPTAN1 ACTN4 ACTN3	7.70e-04	23	112	3	M913
Pathway	KEGG_NITROGEN_METABOLISM	CA9 CA13 GLS	7.70e-04	23	112	3	M4629
Pathway	REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE	LIN7C APBA1 LIN7A	7.70e-04	23	112	3	M12627
Pathway	REACTOME_RHO_GTPASE_CYCLE	KALRN SPTAN1 OCRL PAK1 PAK2 PAK3 PKN1 PKN2 FGD5 SCRIB DNMBP	8.97e-04	450	112	11	M27078
Pathway	REACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS	LIN7C APBA1 GRIN2C LIN7A MAPK1	9.06e-04	94	112	5	M2843
Pathway	REACTOME_RHO_GTPASE_EFFECTORS	MYLK KIF2B PAK1 PAK2 PAK3 PKN1 PKN2 MAPK1	1.02e-03	257	112	8	MM14755
Pathway	KEGG_FOCAL_ADHESION	MYLK ACTN4 ACTN3 PAK1 PAK2 PAK3 MAPK1	1.04e-03	199	112	7	M7253
Pathway	REACTOME_NERVOUS_SYSTEM_DEVELOPMENT	KALRN SPTA1 SPTAN1 SPTB PAK1 PAK2 PAK3 MAPK1	1.12e-03	261	112	8	MM15676
Pathway	WP_MET_IN_TYPE_1_PAPILLARY_RENAL_CELL_CARCINOMA	PAK1 PAK2 PAK3 MAPK1	1.23e-03	59	112	4	M39750
Pathway	REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES	PAK1 PAK2 PAK3	1.24e-03	27	112	3	MM14809
Pathway	REACTOME_VEGFR2_MEDIATED_VASCULAR_PERMEABILITY	PAK1 PAK2 PAK3	1.24e-03	27	112	3	M27422
Pathway	WP_REGULATION_OF_ACTIN_CYTOSKELETON	MYLK FGF16 PAK1 PAK2 PAK3 MAPK1	1.24e-03	150	112	6	M39520
Pathway	WP_REGULATION_OF_ACTIN_CYTOSKELETON	MYLK FGF16 PAK1 PAK2 PAK3 MAPK1	1.33e-03	152	112	6	MM15834
Pathway	BIOCARTA_FAS_PATHWAY	SPTAN1 PAK1 PAK2	1.38e-03	28	112	3	MM1396
Pathway	BIOCARTA_TNFR1_PATHWAY	SPTAN1 PAK1 PAK2	1.38e-03	28	112	3	MM1516
Pathway	WP_IL18_SIGNALING	PLA2G7 TRPM7 REL ADAMTS5 EEF2 HPS1 PKN1 MAPK1	1.49e-03	273	112	8	M39818
Pathway	BIOCARTA_TNFR1_PATHWAY	SPTAN1 PAK1 PAK2	1.53e-03	29	112	3	M3618
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	MYLK KALRN SPTAN1 OCRL KIF2B PAK1 PAK2 PAK3 PKN1 PKN2 FGD5 SCRIB MAPK1 DNMBP	1.67e-03	720	112	14	M41838
Pathway	BIOCARTA_FAS_PATHWAY	SPTAN1 PAK1 PAK2	1.70e-03	30	112	3	M9503
Pathway	PID_P38_ALPHA_BETA_PATHWAY	PAK1 PAK2 PAK3	1.70e-03	30	112	3	M76
Pathway	REACTOME_VEGFR2_MEDIATED_VASCULAR_PERMEABILITY	PAK1 PAK2 PAK3	1.70e-03	30	112	3	MM15170
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RPGRIP1 MYLK COL20A1 PCDHGA4 SPTA1 SPTAN1 HSPH1 MAFA CCNO REL ACTN4 ST3GAL2 TMEM43 ACTN3 ECE1 LIG4 EEF2 TNRC18 CIAO3 PABPC3 GLS ATP11A POLQ BAHCC1 KPNB1	1.69e-09	1442	146	25	35575683
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SHANK1 ANK3 TTC28 KALRN TRPM7 POLG SPTAN1 SPTB HSPH1 APBA1 ACTN4 RILPL1 STAB1 DGLUCY EEF2 CIAO3 GLS MIB1 PAK1 PAK2 TTC17 SCRIB KPNB1	4.55e-09	1285	146	23	35914814
Pubmed	The small GTPase Rac1 regulates auditory hair cell morphogenesis.	SPTA1 SPTAN1 PAK1 PAK2 PAK3	3.85e-08	23	146	5	20016102
Pubmed	Cell organization, growth, and neural and cardiac development require αII-spectrin.	ANK3 SPTA1 SPTAN1 SPTB	6.14e-08	10	146	4	22159418
Pubmed	Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice.	PAK1 PAK2 PAK3	7.25e-08	3	146	3	15182717
Pubmed	Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation.	PAK1 PAK2 PAK3	7.25e-08	3	146	3	10075701
Pubmed	The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.	PAK1 PAK2 PAK3	7.25e-08	3	146	3	23335370
Pubmed	Group I Paks as therapeutic targets in NF2-deficient meningioma.	PAK1 PAK2 PAK3	7.25e-08	3	146	3	25596744
Pubmed	The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties.	PAK1 PAK2 PAK3	7.25e-08	3	146	3	18507705
Pubmed	Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases.	PAK1 PAK2 PAK3	7.25e-08	3	146	3	38785043
Pubmed	The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity.	PAK1 PAK2 PAK3	7.25e-08	3	146	3	11278486
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SHANK1 ANK3 KALRN ZNF618 SPTAN1 DAPK1 KIF7 GDA EEF2 PABPC3 PAK1 PAK2 PAK3 PKN1 SCRIB MAPK1 AGRN KPNB1	1.34e-07	963	146	18	28671696
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	SPG7 ANK3 POLG HSPH1 CYP27B1 NOB1 ACTN4 ST3GAL2 PABPN1L GRSF1 KIAA0753 ALKBH8 TIA1 HPS1 FAM20B ATP11A HSD3B1 MAPK1 AGRN	1.57e-07	1084	146	19	11544199
Pubmed	PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway.	PAK1 PAK2 PAK3 MAPK1	2.89e-07	14	146	4	18586681
Pubmed	Identification of multiple, novel, protein kinase C-related gene products.	PRKCH PKN1 PKN2	2.89e-07	4	146	3	7988719
Pubmed	Scrib regulates PAK activity during the cell migration process.	PAK1 PAK2 SCRIB	2.89e-07	4	146	3	18716323
Pubmed	Pak to the future.	PAK1 PAK2 PAK3	2.89e-07	4	146	3	10461188
Pubmed	The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.	SPTA1 SPTAN1 SPTB	2.89e-07	4	146	3	21566095
Pubmed	Remarkable homology among the internal repeats of erythroid and nonerythroid spectrin.	SPTA1 SPTAN1 SPTB	2.89e-07	4	146	3	3862089
Pubmed	Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site.	SPTA1 SPTAN1 SPTB	2.89e-07	4	146	3	12820899
Pubmed	CHL1 cooperates with PAK1-3 to regulate morphological differentiation of embryonic cortical neurons.	PAK1 PAK2 PAK3	2.89e-07	4	146	3	19819308
Pubmed	Contrasting localizations of MALS/LIN-7 PDZ proteins in brain and molecular compensation in knockout mice.	LIN7C APBA1 LIN7A	7.20e-07	5	146	3	11104771
Pubmed	Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.	PAK1 PAK2 PAK3	7.20e-07	5	146	3	23509247
Pubmed	CASK deletion in intestinal epithelia causes mislocalization of LIN7C and the DLG1/Scrib polarity complex without affecting cell polarity.	LIN7C SPTAN1 LIN7A SCRIB	1.37e-06	20	146	4	19726564
Pubmed	Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin.	PAK1 PAK2 PAK3	1.44e-06	6	146	3	12237306
Pubmed	Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons.	PAK1 PAK2 PAK3	1.44e-06	6	146	3	33482876
Pubmed	Pak1 is involved in dendrite initiation as a downstream effector of Rac1 in cortical neurons.	PAK1 PAK2 PAK3	1.44e-06	6	146	3	12213441
Pubmed	Chromosomal location of three spectrin genes: relationship to the inherited hemolytic anemias of mouse and man.	SPTA1 SPTAN1 SPTB	2.51e-06	7	146	3	3186715
Pubmed	A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.	LIN7C APBA1 LIN7A	2.51e-06	7	146	3	9753324
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	EMC1 TM9SF1 HSPH1 FKBP9 ST3GAL2 TMEM43 ECE1 GGT7 PLA2R1 EEF2 CELSR1 RRAGA LOXL2 FAM20B TTC17 SCRIB AGRN MGRN1	3.16e-06	1201	146	18	35696571
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	SPTAN1 HSPH1 NOB1 ACTN4 OCRL GRSF1 EEF2 KANSL1 ADSS2 SERPINB12 GLS MIB1 PKN2 NUP93 SCRIB MAPK1 AGRN KPNB1 TPI1	4.22e-06	1353	146	19	29467282
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SPG7 KALRN POLG NOB1 ECE1 RALGAPA2 GGT7 CELSR1 INTS5 TNRC18 KANSL1 ANKRD34A PKN1 DNMBP PRDM16 AGRN BAHCC1	4.29e-06	1105	146	17	35748872
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZNF618 HSPH1 BACE1 RALGAPA2 KIAA0753 GDA TNRC18 GLS ATP11A N4BP1 PRDM16	8.16e-06	493	146	11	15368895
Pubmed	A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels.	LIN7C APBA1 LIN7A	8.51e-06	10	146	3	14960569
Pubmed	Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization.	ANK3 SPTAN1 SPTB HSPH1 ACTN4 GDA EEF2 MAPK1 KPNB1 TPI1	8.53e-06	403	146	10	30562941
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	EMC1 NOB1 RABAC1 DAPK1 TMEM43 OCRL ECE1 RALGAPA2 PAK2 TTC17 ATP11A SCRIB AGRN	1.16e-05	719	146	13	35337019
Pubmed	Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.	KALRN SPTAN1 SPTB	1.17e-05	11	146	3	17607528
Pubmed	Cloning, central nervous system expression and chromosomal mapping of the mouse PAK-1 and PAK-3 genes.	PAK1 PAK2 PAK3	1.17e-05	11	146	3	10352232
Pubmed	Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture.	PAK1 PAK2 PAK3	1.55e-05	12	146	3	18824165
Pubmed	Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport.	LIN7C APBA1 LIN7A	1.55e-05	12	146	3	10846156
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	TTC28 HSPH1 NOB1 ACTN4 OCRL ECE1 KIF7 MIB1 TTC17 NUP93 DNMBP AGRN KPNB1 NIN	1.56e-05	853	146	14	28718761
Pubmed	Quantifying domain-ligand affinities and specificities by high-throughput holdup assay.	LIN7C LIN7A PTPN4 SCRIB	1.58e-05	36	146	4	26053890
Pubmed	Activation of PAK1/2 during the shedding of platelet microvesicles.	PAK1 PAK2	1.75e-05	2	146	2	20523167
Pubmed	ACTN3 and MLCK genotype associations with exertional muscle damage.	MYLK ACTN3	1.75e-05	2	146	2	15817725
Pubmed	A deletional frameshift mutation of the beta-spectrin gene associated with elliptocytosis in spectrin Tokyo (beta 220/216).	SPTA1 SPTB	1.75e-05	2	146	2	1391962
Pubmed	Dual loss of human POLQ and LIG4 abolishes random integration.	LIG4 POLQ	1.75e-05	2	146	2	28695890
Pubmed	p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties.	PAK1 PAK3	1.75e-05	2	146	2	21115725
Pubmed	Chaperone activity and prodan binding at the self-associating domain of erythroid spectrin.	SPTA1 SPTB	1.75e-05	2	146	2	15492010
Pubmed	Beta spectrin kissimmee: a spectrin variant associated with autosomal dominant hereditary spherocytosis and defective binding to protein 4.1.	SPTA1 SPTB	1.75e-05	2	146	2	8102379
Pubmed	Beta-spectrin Promiss-ao: a translation initiation codon mutation of the beta-spectrin gene (ATG --> GTG) associated with hereditary spherocytosis and spectrin deficiency in a Brazilian family.	SPTA1 SPTB	1.75e-05	2	146	2	9414314
Pubmed	Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation.	PAK1 MAPK1	1.75e-05	2	146	2	15542607
Pubmed	Variations in both α-spectrin (SPTA1) and β-spectrin ( SPTB ) in a neonate with prolonged jaundice in a family where nine individuals had hereditary elliptocytosis.	SPTAN1 SPTB	1.75e-05	2	146	2	24193021
Pubmed	Mutation of a highly conserved residue of betaI spectrin associated with fatal and near-fatal neonatal hemolytic anemia.	SPTA1 SPTB	1.75e-05	2	146	2	9005995
Pubmed	Identification of the molecular defect in the erythrocyte membrane skeleton of some kindreds with hereditary spherocytosis.	SPTA1 SPTB	1.75e-05	2	146	2	7104494
Pubmed	A genetic defect in the binding of protein 4.1 to spectrin in a kindred with hereditary spherocytosis.	SPTA1 SPTB	1.75e-05	2	146	2	6215583
Pubmed	Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions.	PAK1 PAK2	1.75e-05	2	146	2	15047871
Pubmed	Spectrin Nice (beta 220/216): a shortened beta-chain variant associated with an increase of the alpha I/74 fragment in a case of elliptocytosis.	SPTA1 SPTB	1.75e-05	2	146	2	3580577
Pubmed	Recurrent fatal hydrops fetalis associated with a nucleotide substitution in the erythrocyte beta-spectrin gene.	SPTA1 SPTB	1.75e-05	2	146	2	7883966
Pubmed	Spectrin Cosenza: a novel beta chain variant associated with Sp alphaI/74 hereditary elliptocytosis.	SPTA1 SPTB	1.75e-05	2	146	2	9163587
Pubmed	Novel roles of PRK1 and PRK2 in cilia and cancer biology.	PKN1 PKN2	1.75e-05	2	146	2	32127582
Pubmed	Identification of three novel spectrin alpha I/74 mutations in hereditary elliptocytosis: further support for a triple-stranded folding unit model of the spectrin heterodimer contact site.	SPTA1 SPTB	1.75e-05	2	146	2	8018926
Pubmed	The p21-activated kinase 2 (PAK2), but not PAK1, regulates contraction-stimulated skeletal muscle glucose transport.	PAK1 PAK2	1.75e-05	2	146	2	32597567
Pubmed	The subcellular localization of type I p21-activated kinases is controlled by the disordered variable region and polybasic sequences.	PAK1 PAK2	1.75e-05	2	146	2	31391252
Pubmed	αII-spectrin regulates invadosome stability and extracellular matrix degradation.	SPTA1 SPTAN1	1.75e-05	2	146	2	25830635
Pubmed	The p21-activated kinase PAK3 forms heterodimers with PAK1 in brain implementing trans-regulation of PAK3 activity.	PAK1 PAK3	1.75e-05	2	146	2	22815483
Pubmed	Erythrocyte spectrin is comprised of many homologous triple helical segments.	SPTA1 SPTB	1.75e-05	2	146	2	6472478
Pubmed	Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis.	ACTN3 MIB1	1.75e-05	2	146	2	33637766
Pubmed	Differential expression of murine CGI-105 gene in 3T3-L1 cells by adrenocorticotropic hormones.	FAHD2B FAHD2A	1.75e-05	2	146	2	15774318
Pubmed	PAK1, PAK1Δ15, and PAK2: similarities, differences and mutual interactions.	PAK1 PAK2	1.75e-05	2	146	2	31748572
Pubmed	Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats.	PAK1 PAK3	1.75e-05	2	146	2	23622267
Pubmed	Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases.	PAK1 PAK2	1.75e-05	2	146	2	19435845
Pubmed	An insertional frameshift mutation of the beta-spectrin gene associated with elliptocytosis in spectrin nice (beta 220/216).	SPTA1 SPTB	1.75e-05	2	146	2	2070088
Pubmed	Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis.	CELSR1 SCRIB	1.75e-05	2	146	2	22095531
Pubmed	Abnormalities of the Duo/Ras-related C3 botulinum toxin substrate 1/p21-activated kinase 1 pathway drive myosin light chain phosphorylation in frontal cortex in schizophrenia.	KALRN PAK1	1.75e-05	2	146	2	22458949
Pubmed	Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis.	PAK1 PAK3	1.75e-05	2	146	2	30858169
Pubmed	Protein kinase C-related kinase 1 and 2 play an essential role in thromboxane-mediated neoplastic responses in prostate cancer.	PKN1 PKN2	1.75e-05	2	146	2	26296974
Pubmed	DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.	POLG POLQ	1.75e-05	2	146	2	16172387
Pubmed	Thrombosis and secondary hemochromatosis play major roles in the pathogenesis of jaundiced and spherocytic mice, murine models for hereditary spherocytosis.	SPTA1 SPTB	1.75e-05	2	146	2	9373273
Pubmed	Novel mutations in SPTA1 and SPTB identified by whole exome sequencing in eight Thai families with hereditary pyropoikilocytosis presenting with severe fetal and neonatal anaemia.	SPTA1 SPTB	1.75e-05	2	146	2	30198572
Pubmed	Expression of p21-activated kinases 1 and 3 is altered in the brain of subjects with depression.	PAK1 PAK3	1.75e-05	2	146	2	27474226
Pubmed	Spectrin mutations in hereditary elliptocytosis and hereditary spherocytosis.	SPTA1 SPTB	1.75e-05	2	146	2	8844207
Pubmed	Spectrin Rouen (beta 220-218), a novel shortened beta-chain variant in a kindred with hereditary elliptocytosis. Characterization of the molecular defect as exon skipping due to a splice site mutation.	SPTA1 SPTB	1.75e-05	2	146	2	2056132
Pubmed	Structural and functional heterogeneity of alpha spectrin mutations involving the spectrin heterodimer self-association site: relationships to hematologic expression of homozygous hereditary elliptocytosis and hereditary pyropoikilocytosis.	SPTA1 SPTB	1.75e-05	2	146	2	2346784
Pubmed	Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase family.	PKN1 PKN2	1.75e-05	2	146	2	7851406
Pubmed	Fenretinide inhibits the proliferation and migration of human liver cancer HepG2 cells by downregulating the activation of myosin light chain kinase through the p38‑MAPK signaling pathway.	MYLK MAPK1	1.75e-05	2	146	2	29767236
Pubmed	PAK1 and PAK2 in cell metabolism regulation.	PAK1 PAK2	1.75e-05	2	146	2	34750857
Pubmed	Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells.	PAK1 PAK2	1.75e-05	2	146	2	9395435
Pubmed	Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms.	PAK1 PAK2	1.75e-05	2	146	2	18411304
Pubmed	Spectrin cagliari. an Ala-->Gly substitution in helix 1 of beta spectrin repeat 17 that severely disrupts the structure and self-association of the erythrocyte spectrin heterodimer.	SPTA1 SPTB	1.75e-05	2	146	2	8226774
Pubmed	A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK.	DAPK1 MIB1	1.75e-05	2	146	2	12351649
Pubmed	Properties of human red cell spectrin heterodimer (side-to-side) assembly and identification of an essential nucleation site.	SPTA1 SPTB	1.75e-05	2	146	2	1634521
Pubmed	Interactions of the alpha-spectrin N-terminal region with beta-spectrin. Implications for the spectrin tetramerization reaction.	SPTAN1 SPTB	1.75e-05	2	146	2	9890967
Pubmed	Glycosylation of erythrocyte spectrin and its modification in visceral leishmaniasis.	SPTA1 SPTB	1.75e-05	2	146	2	22164239
Pubmed	Crystal structure and functional interpretation of the erythrocyte spectrin tetramerization domain complex.	SPTA1 SPTB	1.75e-05	2	146	2	20197550
Pubmed	PLA2R1 mediates tumor suppression by activating JAK2.	PLA2G7 PLA2R1	1.75e-05	2	146	2	24008317
Pubmed	A structural model of the erythrocyte spectrin heterodimer initiation site determined using homology modeling and chemical cross-linking.	SPTA1 SPTB	1.75e-05	2	146	2	17977835
Pubmed	HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases.	PAK1 PAK2 MAPK1	2.01e-05	13	146	3	23317503
Pubmed	Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice.	PAK1 PAK2 PAK3	2.01e-05	13	146	3	30333726
Pubmed	Agrin has a pathological role in the progression of oral cancer.	ANK3 SPTAN1 ACTN4 EEF2 RRAGA GLS AGRN	2.10e-05	197	146	7	29872149
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	SHANK1 ANK3 KALRN SPTAN1 ACTN4 GDA PKN2 MAPK1	2.65e-05	281	146	8	28706196
Interaction	LRRCC1 interactions	ACTN3 KIF7 MIB1 POLQ NIN	2.89e-06	32	143	5	int:LRRCC1
GeneFamily	EF-hand domain containing\|Spectrins	SPTA1 SPTAN1 SPTB	5.49e-06	7	99	3	1113
GeneFamily	C2 domain containing protein kinases	PRKCH PKN1 PKN2	1.86e-05	10	99	3	835
GeneFamily	Ankyrin repeat domain containing	SHANK1 ANK3 DAPK1 ANKRD55 GLS ANKDD1A MIB1 ANKRD34A	5.51e-05	242	99	8	403
GeneFamily	Actinins	ACTN4 ACTN3	1.77e-04	4	99	2	1112
GeneFamily	PDZ domain containing	SHANK1 LIN7C APBA1 LIN7A PTPN4 SCRIB	1.88e-04	152	99	6	1220
GeneFamily	PDZ domain containing\|Crumbs complex	LIN7C LIN7A	1.04e-03	9	99	2	1223
Coexpression	GSE45365_NK_CELL_VS_BCELL_MCMV_INFECTION_DN	CYP27B1 REL GRSF1 INTS5 TIA1 PKN1 FUT7 MGRN1	1.49e-05	199	144	8	M9959
Coexpression	GSE5589_WT_VS_IL10_KO_LPS_STIM_MACROPHAGE_45MIN_DN	ZNF131 REL GDA CELSR1 NLRP10 FAM20B TTC17 MAPK1	1.49e-05	199	144	8	M6648
CoexpressionAtlas	DevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#5_top-relative-expression-ranked_1000	ANK3 TRPM7 ZNF618 BACE1 IDE OCRL KANSL1 MIB1 PKN2 DNMBP AGRN KPNB1 MGRN1	4.77e-07	339	142	13	gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_1000_k5
CoexpressionAtlas	DevelopingKidney_e15.5_S-shaped body_emap-27855_k-means-cluster#5_top-relative-expression-ranked_1000	CWH43 BACE1 IDE KANSL1 TIA1 MIB1 PKN2 DNMBP AGRN	8.65e-07	152	142	9	gudmap_developingKidney_e15.5_S-shaped body_1000_k5
CoexpressionAtlas	DevelopingKidney_e15.5_Medullary collecting duct_emap-28063_k-means-cluster#4_top-relative-expression-ranked_1000	ANK3 BACE1 IDE KANSL1 TIA1 MIB1 PKN2 DNMBP AGRN KPNB1 MGRN1	1.51e-06	261	142	11	gudmap_developingKidney_e15.5_Medullary collecting duct_1000_k4
CoexpressionAtlas	DevelopingKidney_e13.5_podocyte cells_emap-27773_k-means-cluster#4_top-relative-expression-ranked_1000	PLA2G7 KALRN ST3GAL2 ACTN3 CHGB LIG4 CELSR1 SLC9A5 TTC23 WNK4 NIN	8.10e-06	311	142	11	gudmap_developingKidney_e13.5_podocyte cells_1000_k4
CoexpressionAtlas	DevelopingKidney_e15.5_S-shaped body_emap-27855_top-relative-expression-ranked_1000	MBLAC2 CWH43 POLG BACE1 IDE RILPL1 CELSR1 SLC9A5 KANSL1 TIA1 PTPRO MIB1 PKN2 FGD5 DNMBP PRDM16 AGRN NIN	8.13e-06	811	142	18	gudmap_developingKidney_e15.5_S-shaped body_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#4_top-relative-expression-ranked_1000	ANK3 TTC28 ZNF618 BACE1 TRIM71 IDE KANSL1 MIB1 DNMBP AGRN KPNB1 MGRN1	1.11e-05	385	142	12	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000_k4
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#3_top-relative-expression-ranked_1000	LIN7C ANK3 IDE PTPN4 KANSL1 RRAGA MIB1 PAK3 DNMBP AGRN KPNB1	3.94e-05	369	142	11	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k3_1000
CoexpressionAtlas	DevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_k-means-cluster#5_top-relative-expression-ranked_1000	TRPM7 BACE1 KANSL1 TIA1 MIB1 PKN2 AGRN MGRN1	6.83e-05	203	142	8	gudmap_developingKidney_e15.5_Ureteral Smooth Musc_1000_k5
CoexpressionAtlas	DevelopingKidney_e15.5_Medullary collecting duct_emap-28063_top-relative-expression-ranked_1000	ANK3 BACE1 GCGR IDE CELSR1 KANSL1 TIA1 PTPRO MIB1 PKN2 DNMBP PRDM16 AGRN WNK4 KPNB1 MGRN1	7.50e-05	786	142	16	gudmap_developingKidney_e15.5_Medullary collecting duct_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#2_top-relative-expression-ranked_500	ANK3 TTC28 KALRN ZNF618 KANSL1 DNMBP AGRN KPNB1	8.37e-05	209	142	8	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_500_k2
CoexpressionAtlas	DevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_top-relative-expression-ranked_1000	ANK3 TRPM7 ZNF618 BACE1 IDE OCRL CELSR1 KANSL1 TIA1 MIB1 PKN2 DNMBP PRDM16 AGRN KPNB1 MGRN1	9.35e-05	801	142	16	gudmap_developingKidney_e15.5_ureter tip_1000_flank cortic collct
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_top-relative-expression-ranked_1000	MYLK ANK3 TTC28 KALRN ZNF618 BACE1 TRIM71 IDE CHGB KANSL1 PTPRO MIB1 DNMBP AGRN KPNB1 MGRN1	1.19e-04	818	142	16	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000
CoexpressionAtlas	DevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_k-means-cluster#3_top-relative-expression-ranked_1000	CWH43 ANK3 BACE1 IDE KANSL1 TIA1 MIB1 DNMBP AGRN MGRN1	2.40e-04	379	142	10	gudmap_developingKidney_e15.5_1000_k3
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CWH43 KALRN TRPM7 DAPK1 GCGR PAPSS1 NUP93 WNK4	2.30e-07	192	145	8	6fb56d062c35617b18b927704bf5fba894faed81
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CWH43 KALRN TRPM7 DAPK1 GCGR PAPSS1 NUP93 WNK4	2.39e-07	193	145	8	fa8bcf2a5ab7b08fae98a1466a936995142b4309
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ANK3 DAPK1 TRIM71 CAPN8 CELSR1 ATP11A PRDM16	2.63e-06	186	145	7	2ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell	Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|World / Lineage, Cell type, age group and donor	ANK3 DAPK1 TRIM71 ABHD17C CAPN8 CELSR1 PRDM16	2.73e-06	187	145	7	81cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM7 GCGR WDFY2 ABHD17C PTPN4 PRDM16 WNK4	3.03e-06	190	145	7	b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CWH43 TRPM7 DAPK1 GCGR PAPSS1 NUP93 WNK4	3.36e-06	193	145	7	b397c14ac1e34c6be3f25d4417d200bc518d3048
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CWH43 TRPM7 DAPK1 GCGR PAPSS1 NUP93 WNK4	3.36e-06	193	145	7	241a60d1f0d5832638fb3e1e4b7afa7387ea3c75
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	MYLK SGCA ADAMTS5 LIN7A EEF2 PAK3 NUP93	4.25e-06	200	145	7	dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCell	droplet-Lung-nan-3m-Myeloid-Proliferating_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKRD55 GGT7 R3HCC1L CCDC149 PAK1 POLQ	1.42e-05	160	145	6	8a7a73b0ee1877fe02d47f745d36ae2858b529e1
ToppCell	facs-Spleen-nan-3m-Hematologic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2G7 CDHR3 APBA1 GDA PTPRO PAK1	1.47e-05	161	145	6	45591addc765760db6029ac19e80573373d1d917
ToppCell	facs-Spleen-nan-3m-Hematologic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2G7 CDHR3 APBA1 GDA PTPRO PAK1	1.47e-05	161	145	6	8741b91a62c9a8ce377ef6533d323b65beb93c63
ToppCell	facs-Spleen-nan-3m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2G7 CDHR3 APBA1 GDA PTPRO PAK1	1.47e-05	161	145	6	9cf1dcf0e7ca9e35c46c094a6b78f98d1f6b9276
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIT1 COL20A1 ADAMTS5 ACTN3 PTPN4 PTPRO	1.69e-05	165	145	6	1703d3eb644b3c743ad3c5532b1d29ea010c79c8
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor_pre-Lymphocytic-T\|bone_marrow / Manually curated celltypes from each tissue	FGF16 LIN7A PLA2R1 ALAS1 FGD5 POLQ	1.75e-05	166	145	6	20f248d95c86eb52a1efe9abe73123fbe4206caf
ToppCell	facs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPGRIP1 GARNL3 KALRN NLRP10 POLQ BAHCC1	2.01e-05	170	145	6	d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOB1 BCLAF3 PTPRO MIB1 PAK1 FUT7	2.29e-05	174	145	6	ff13a5c55d18b951315908f33cb47c7f9cb901bf
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF280A RPGRIP1 TSPEAR RALGAPA2 PRKCH FUT7	2.68e-05	179	145	6	dfd5b25f2a6a5a8bf4714f1516cb0997de72b06f
ToppCell	3'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CA9 CWH43 KALRN DAPK1 WDFY2 PAK3	2.68e-05	179	145	6	906555ce2ca264a0215b120c7ff7c9b411de6a34
ToppCell	droplet-Liver-nan-3m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC28 KALRN TPBGL STAB1 PLA2R1 ATP11A	2.85e-05	181	145	6	fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SPTB APBA1 TSPEAR PLA2R1 PTPRO PAK1	2.85e-05	181	145	6	5bf7aa43f6e6ecce15c95928b91195544d6928c4
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SPTB APBA1 TSPEAR PLA2R1 PTPRO PAK1	2.85e-05	181	145	6	8e751f5d7cd2d328ec0196d874e8a507e8c4e1a9
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF280A TSPEAR TPBGL CELSR1 ANKDD1A FGD5	2.94e-05	182	145	6	f231e86524b628e6e11ac33d5c34be99d454a92a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GCGR WDFY2 ABHD17C PTPN4 PRDM16 WNK4	2.94e-05	182	145	6	041bc819e6cf2618bf86bce8dfe2df673f392ba3
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2G7 CHGB ECE1 STAB1 CELSR1 AGRN	3.04e-05	183	145	6	6c4a09c02e30e1f24dde39f8cb8c5b453826ee2e
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CWH43 TRPM7 GCGR PAPSS1 NUP93 WNK4	3.04e-05	183	145	6	f3728b1a51951c7349f77a3e4d2671ca3a8d2a44
ToppCell	Frontal_cortex-Neuronal-Excitatory\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CWH43 KALRN HSPH1 CSMD2 GDA MAPK1	3.13e-05	184	145	6	6e17c8151d6dc543de16d804db956c63c3fda414
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CWH43 TRPM7 GCGR PAPSS1 NUP93 WNK4	3.13e-05	184	145	6	8939b6d795992775df0ff58ed1ec9d421a00bcc4
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANK3 TSPEAR DAPK1 CELSR1 ATP11A PRDM16	3.23e-05	185	145	6	0d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ANK3 DAPK1 TRIM71 ABHD17C CAPN8 PRDM16	3.23e-05	185	145	6	98b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYLK ANK3 SGCA ADAMTS5 LIN7A PAK3	3.33e-05	186	145	6	6add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma-proliferating_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	TTC28 KALRN FKBP9 HMCN2 LOXL2 FGD5	3.33e-05	186	145	6	a844d4f79e0ad5d6c60a4488ffd8f4f21b7eed04
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TSPEAR DAPK1 TRIM71 CELSR1 ATP11A PRDM16	3.43e-05	187	145	6	58d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SPTB ACTN4 PLA2R1 PTPRO MIB1 ADAMTS14	3.43e-05	187	145	6	24c2a3962da364e46e98abeab5f8234376fa26bb
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GARNL3 ANK3 FKBP9 RILPL1 LIG4 GDPGP1	3.43e-05	187	145	6	f5a202d5f8eb57b57d80815ce98774e04c387383
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	LIN7A CELSR1 GLS ATP11A PRDM16 AGRN	3.53e-05	188	145	6	eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	GARNL3 MYLK KALRN HMCN2 GLS PRDM16	3.53e-05	188	145	6	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CWH43 TRPM7 PAPSS1 NUP93 PRDM16 WNK4	3.53e-05	188	145	6	ab6fa1beff91584d9303c2a33735de89aae8d5cd
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CDHR3 CA13 ADAMTS5 ANKRD55 PLA2R1 PTPRO	3.53e-05	188	145	6	3139540a656c0436b2123ea50741ff8d00112165
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CWH43 TRPM7 DAPK1 GCGR PAPSS1 WNK4	3.64e-05	189	145	6	e127e3be626bc513e151d41812f0b7adb89d5da6
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CWH43 TRPM7 DAPK1 GCGR PAPSS1 WNK4	3.64e-05	189	145	6	ff637ae0afdb1fdc67451be7e1e4fe575fbcfff4
ToppCell	droplet-Heart-nan-24m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2G7 FAHD2A ECE1 STAB1 CELSR1 WNK4	3.64e-05	189	145	6	1137583e21d874c201c20581ba1995e2bfa3de59
ToppCell	droplet-Heart-nan-24m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2G7 FAHD2A ECE1 STAB1 CELSR1 WNK4	3.75e-05	190	145	6	7068754c29f63a331e2b6c54715f3b26f37ad32b
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KALRN LIN7A GDA GLS PAK1 NIN	3.75e-05	190	145	6	d594da827e3c16644952b9589cc12b947ce36279
ToppCell	COVID-19-lung-Artery_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TTC28 HSPH1 ECE1 RALGAPA2 PRKCH FGD5	3.75e-05	190	145	6	07b675befcd1d0a9c90cb17b5d22323468325d51
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2G7 CHGB ECE1 STAB1 CELSR1 WNK4	3.75e-05	190	145	6	6f71a9f74af7cd9a674753cfc9833ebe5bba0fa2
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KALRN LIN7A GDA GLS PAK1 NIN	3.75e-05	190	145	6	49e09cdb843b3d889a06a811aa5affae68b25a75
ToppCell	Children_(3_yrs)-Epithelial-club_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ANK3 CCNO DAPK1 CAPN8 CELSR1 PRDM16	3.86e-05	191	145	6	23776c7302cead3881b39127398f3b3e0d27885e
ToppCell	COVID-19-Heart-EC_(POSTN)\|Heart / Disease (COVID-19 only), tissue and cell type	DAPK1 ECE1 RALGAPA2 PLA2R1 PRKCH FGD5	3.97e-05	192	145	6	c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB ACTN4 ECE1 RALGAPA2 STAB1 PRKCH	4.21e-05	194	145	6	e8102c8811333f04de7280b7d9b6b85cebb815ac
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB ACTN4 ECE1 RALGAPA2 STAB1 PRKCH	4.21e-05	194	145	6	4b0d63babb8a46ff45731d5f82b29ccaf6c9402d
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ANK3 CCNO DAPK1 CAPN8 CELSR1 PRDM16	4.33e-05	195	145	6	dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANK3 TRPM7 GCGR WDFY2 GLS WNK4	4.33e-05	195	145	6	a38d9dc6192aea673d96fda6b25e81223fda3abf
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ANK3 CCNO ABHD17C CAPN8 CELSR1 FER1L6-AS2	4.33e-05	195	145	6	e7230a849ea31e6eef9bc6f5468938499450582d
ToppCell	droplet-Heart-nan-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2G7 ECE1 RALGAPA2 STAB1 CELSR1 WNK4	4.45e-05	196	145	6	e386526332138e636aef2542c11316347a45689c
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FKBP9 ACTN4 EEF2 ADSS2 LOXL2 MAPK1	4.45e-05	196	145	6	151f1a29a91f8b234e9b6ed062666357a2f69128
ToppCell	Bronchial-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ANK3 DAPK1 CAPN8 CELSR1 ATP11A PRDM16	4.85e-05	199	145	6	5f7da3eab58ace6cddb3179a415cd839d5767958
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ANK3 DAPK1 CAPN8 CELSR1 ATP11A PRDM16	4.85e-05	199	145	6	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_activated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CYP27B1 REL GCGR ANKRD55 LOXL2 PAK1	4.85e-05	199	145	6	f4ab29f99ce45a3044d2e9f356dc24d3c5e7121f
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	MYLK ANK3 SGCA ADAMTS5 LIN7A PAK3	4.98e-05	200	145	6	c596a53c0b63c9deaac7d99fcbdd94ecfa96b86c
ToppCell	Control-Epithelial_alveolar-AT_1-AT2_Progenitor\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TSPEAR GCGR CELSR1 ALKBH8 PRDM16	1.02e-04	142	145	5	94e277f038f4006d99ff50222b0f5cf89bc3d46d
ToppCell	E16.5-samps-Myeloid-Fetal_macrophage-macrophage_-_intermediate_-_unactivated\|E16.5-samps / Age Group, Lineage, Cell class and subclass	COL20A1 APBA1 TPBGL STAB1 PTPRO	1.32e-04	150	145	5	60fdd266aaca1b589b9a77465a4a7fad4921339a
ToppCell	droplet-Lung-nan-3m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKRD55 GGT7 CCDC149 PAK1 POLQ	1.40e-04	152	145	5	77b319f594d5e4df29034bbf69c7490076f89dd3
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-mLTo\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RPGRIP1 DAPK1 TPBGL KIAA0753 FUT7	1.63e-04	157	145	5	c779a53b2c67d566f5d417e753cd17196a6bfd1c
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDHR3 SPTA1 SPTB TTC23 AGRN	1.78e-04	160	145	5	56e6f4b82b5dc41c45f9d253c2db314a6f702b84
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDHR3 SPTA1 SPTB TTC23 AGRN	1.78e-04	160	145	5	bb1b966fb9e801db15e67d03e49db4609d6f935a
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDHR3 SPTA1 SPTB TTC23 AGRN	1.83e-04	161	145	5	60f433eab9d5531bdf6aa86b0265f20b866b904c
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Adult / Lineage, Cell type, age group and donor	ANK3 DAPK1 CAPN8 ATP11A PRDM16	1.94e-04	163	145	5	e819a1d6d28290854aa0672b3a18fa9e293d8f23
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Basal_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	CA9 GARNL3 MAFA CCNO ECE1	1.94e-04	163	145	5	f21951e63188eb0c04675a8f81a0da495c26c007
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CA9 DGLUCY PTPRO PAK1 FUT7	2.00e-04	164	145	5	54f8f11d2fa899005530c08e7a1ee728c7b0799c
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTA1 DAPK1 GDA SLC9A5 NIN	2.00e-04	164	145	5	f9a2cc12179d5621c9174ec01d7418a71edd28d1
ToppCell	facs-Heart-LV-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL20A1 SPTA1 CCNO GDA SCRIB	2.06e-04	165	145	5	84eca6a0f5e996b6955ae79fa102af239098fe8f
ToppCell	facs-Heart-LV-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL20A1 SPTA1 CCNO GDA SCRIB	2.06e-04	165	145	5	af59a095ecc6758abc13d763c00e44447c488167
ToppCell	droplet-Lung-3m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l15\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	INTS5 NLRP10 PAK1 FUT7 BAHCC1	2.06e-04	165	145	5	1d0f60bf47a40ac916f0fcb5532a968742a0edbb
ToppCell	facs-Lung-Endomucin-3m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP76 TNRC18 PTPRO FUT7 GDPGP1	2.11e-04	166	145	5	a2ce44702a0cd5fa5872cac3302d3c451205feef
ToppCell	facs-Lung-Endomucin-3m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP76 TNRC18 PTPRO FUT7 GDPGP1	2.11e-04	166	145	5	0f641302a6b71c4badaaf20f51162bfc2386b167
ToppCell	Substantia_nigra-Endothelial-MURAL\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MYLK SGCA ACTN4 PLA2R1 ADAMTS14	2.24e-04	168	145	5	271a81c59a9a75bac6107c68fead03e7f35bc192
ToppCell	Substantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MYLK SGCA ACTN4 PLA2R1 ADAMTS14	2.24e-04	168	145	5	b220e732eb7b204fc263a9f2e8ddae6bf9fa98f4
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Microglia/Mac\|Myeloid_cells / Location, Cell class and cell subclass	ABHD17C DNAH1 CAPN8 ALKBH8 CCDC149	2.30e-04	169	145	5	dba8f5599aa21feef5b7fdfed2e3ab54748d80f7
ToppCell	facs-Marrow-KLS-24m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GARNL3 ECE1 SLC9A5 PTPRO FUT7	2.30e-04	169	145	5	d6ad3b637de2935c656aad47ad82d6e8a8bd1227
ToppCell	facs-Marrow-KLS-24m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GARNL3 ECE1 SLC9A5 PTPRO FUT7	2.30e-04	169	145	5	60ef186518d0dc63dbded2a77c65cfe3129df754
ToppCell	facs-Lung-24m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l14\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CA9 OCRL R3HCC1L POLQ MGRN1	2.30e-04	169	145	5	813472d429c0b12580b17b440e00a6d8beb7947f
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ANK3 DAPK1 CAPN8 PRDM16 C13orf42	2.36e-04	170	145	5	a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_4\|390C / Donor, Lineage, Cell class and subclass (all cells)	PLA2G7 DAPK1 TPBGL PTPRO HHIPL1	2.36e-04	170	145	5	439167e44a1bd5ac8e1e457351dd202ec968db46
ToppCell	Children_(3_yrs)-Immune-dendritic_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ZNF280A ST3GAL2 ANKRD55 LOXL2 PAK1	2.43e-04	171	145	5	6a5ac0f56bd7b4543be103100fb735ca6bc5b8bf
ToppCell	E12.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ZNF131 IDE ANKRD55 PRKCH SCRIB	2.49e-04	172	145	5	3b9be685fcd1634498a603b692f5ac6ddd0de176
ToppCell	droplet-Kidney-nan-3m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIM71 ADAMTS5 PLA2R1 FGD5 HHIPL1	2.49e-04	172	145	5	073a503dc922e3e3ac3528e249b0f8b74402110b
ToppCell	Globus_pallidus-Endothelial-MURAL-M1(Rgs5Acta2)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	MYLK ACTN4 PLA2R1 LOXL2 ADAMTS14	2.56e-04	173	145	5	51328a60ffaf34fa0f7df6084d348b5efc9917f5
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANK3 TRPM7 GCGR WDFY2 WNK4	2.56e-04	173	145	5	0c74bdb40e635d906fd180412c23bf7fed61621e
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KALRN SPTB CEP76 SLC9A5 SCRIB	2.56e-04	173	145	5	12f779b8dce79431b2d1002ba524dd3f9566aeb0
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK TTC28 PLA2R1 LOXL2 ADAMTS14	2.56e-04	173	145	5	2415b6ff49f334da570577d4e93484d024a3dbd5
ToppCell	Globus_pallidus-Endothelial-MURAL\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	MYLK ACTN4 PLA2R1 LOXL2 ADAMTS14	2.56e-04	173	145	5	b77cd5dbda3a206922f20224f4e10a3bf712f7db
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK TTC28 PLA2R1 LOXL2 ADAMTS14	2.56e-04	173	145	5	2acd0693a2dfe04e3c1b2125ea63efe92d13150b
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	ECE1 STAB1 PRKCH FGD5 AGRN	2.63e-04	174	145	5	b4f3f5334803e5903bc496decf923f2e44f7fa3c
ToppCell	Control-Myeloid-MoAM2,_CCL18\|Control / Condition, Lineage and Cell class	PLA2G7 ZNF618 STAB1 CELSR1 ADAMTS14	2.63e-04	174	145	5	4c64ff5666812fb4efa440ba4faeca51d916d68e
ToppCell	10x5'-bone_marrow-Myeloid_Mac-Intestinal_macrophages\|bone_marrow / Manually curated celltypes from each tissue	TTC28 FKBP9 APBA1 DAPK1 STAB1	2.63e-04	174	145	5	0746344d62aa7ab77c378e9d5a9f9238e741a76b
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PLA2G7 STAB1 GDA PTPRO PAK1	2.70e-04	175	145	5	a8b05972e1bec4de73feaa6c4a9bcbe6b50c8044
ToppCell	Control-Myeloid-MoAM2,_CCL18\|Myeloid / Condition, Lineage and Cell class	PLA2G7 ZNF618 STAB1 CELSR1 ADAMTS14	2.84e-04	177	145	5	470f54fe2b21c7350ea471e02039461a3808f700
ToppCell	wk_15-18-Mesenchymal-Chondrocyte-ASPN+_chondrocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	DNAH1 BCLAF3 PLA2R1 ANKDD1A NIN	2.92e-04	178	145	5	a55130670aa95a87b833dd3cd2de461d779e4c06
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYLK ECE1 CSMD2 TLL2 GLS	2.92e-04	178	145	5	a0ab20c588e7d43d0320d4779d9ab95c1c86e297
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SPTB APBA1 TSPEAR PLA2R1 PTPRO	3.00e-04	179	145	5	7394e77e665bf16d3733df91bb12907be460ab44
Drug	6-thioguanine	POLG CCNO LIG4 PTPN4 GDA EEF2 PAK1 POLQ	1.88e-06	130	145	8	CID002723601
Drug	KS24	GRSF1 TIA1 PABPC3	4.99e-06	6	145	3	CID000099135
Disease	Neoplasm Invasiveness	MYLK TRPM7 FGF16 EEF2 ALKBH8 LOXL2 MAPK1	2.92e-05	184	140	7	C0027626
Disease	Hereditary elliptocytosis	SPTA1 SPTB	1.33e-04	4	140	2	cv:C0013902
Disease	hereditary spherocytosis (is_implicated_in)	SPTA1 SPTB	2.21e-04	5	140	2	DOID:12971 (is_implicated_in)
Disease	Hereditary spherocytosis	SPTA1 SPTB	2.21e-04	5	140	2	cv:C0037889
Disease	focal segmental glomerulosclerosis 1 (implicated_via_orthology)	ACTN4 ACTN3	2.21e-04	5	140	2	DOID:0111128 (implicated_via_orthology)
Disease	Anemia, hereditary spherocytic hemolytic	SPTA1 SPTB	2.21e-04	5	140	2	C0221409
Disease	Elliptocytosis, Hereditary	SPTA1 SPTB	3.31e-04	6	140	2	C0013902
Disease	NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE	ACTN4 PTPRO NUP93	3.86e-04	30	140	3	C1868672
Disease	OROFACIODIGITAL SYNDROME VI	KIF7 KIAA0753	4.62e-04	7	140	2	C2745997
Disease	Hereditary spherocytosis	SPTA1 SPTB	6.14e-04	8	140	2	C0037889
Disease	NEURAL TUBE DEFECTS, SUSCEPTIBILITY TO	CELSR1 SCRIB	6.14e-04	8	140	2	C3891448
Disease	ciliopathy (implicated_via_orthology)	RPGRIP1 KIF7 KIAA0753	9.08e-04	40	140	3	DOID:0060340 (implicated_via_orthology)
Disease	temporomandibular joint disorder	SGCA BAHCC1	9.81e-04	10	140	2	EFO_0005279
Disease	aseptic loosening, revision of total knee arthroplasty	ANK3 ADAMTS5 KIF2B	1.05e-03	42	140	3	EFO_0010725, EFO_0020972
Disease	cup-to-disc ratio measurement	ANK3 TTC28 SGCA DAPK1 TRIM71 ACTN4 PKN2 PRDM16	1.07e-03	430	140	8	EFO_0006939
Disease	coronary artery disease (is_implicated_in)	PLA2G7 MYLK KALRN ECE1	1.34e-03	100	140	4	DOID:3393 (is_implicated_in)
Disease	renal fibrosis (biomarker_via_orthology)	ECE1 MAPK1	1.43e-03	12	140	2	DOID:0050855 (biomarker_via_orthology)
Disease	reticulocyte measurement	SPTA1 SPTB FKBP9 ACTN4 ANKRD55 GGT7 SLC9A5 KANSL1 GLS PAK2 PKN2 ATP11A PRDM16	1.56e-03	1053	140	13	EFO_0010700
Disease	Anemia, Hemolytic, Acquired	SPTB TPI1	1.68e-03	13	140	2	C0002879
Disease	Anemia, Hemolytic	SPTB TPI1	1.68e-03	13	140	2	C0002878
Disease	Anemia, Microangiopathic	SPTB TPI1	1.68e-03	13	140	2	C0002889
Disease	Microangiopathic hemolytic anemia	SPTB TPI1	1.68e-03	13	140	2	C0221021
Disease	advanced glycosylation end product-specific receptor, soluble measurement	KANSL1 PRDM16	1.68e-03	13	140	2	EFO_0020131
Disease	Lung Neoplasms	CWH43 ANK3 DAPK1 CHRNA2 EEF2 MAPK1	1.71e-03	265	140	6	C0024121
Disease	Malignant neoplasm of lung	CWH43 ANK3 DAPK1 CHRNA2 EEF2 MAPK1	1.74e-03	266	140	6	C0242379
Disease	Left ventricular noncompaction	MIB1 PRDM16	1.96e-03	14	140	2	C1960469
Disease	endometrial carcinoma	CSMD2 CAPN8 PAK1 PKN1	2.10e-03	113	140	4	EFO_1001512
Disease	longevity	KALRN TMEM43 ECE1 ALKBH8 GLS PRDM16	2.41e-03	284	140	6	EFO_0004300
Disease	Inborn Errors of Metabolism	PLA2G7 TPI1	2.90e-03	17	140	2	C0025521
Disease	Alzheimer disease, brain volume measurement	PAK2 PKN2	2.90e-03	17	140	2	EFO_0006930, MONDO_0004975
Disease	red blood cell density measurement	TRIT1 KALRN TM9SF1 SPTA1 FKBP9 ANKRD55 KANSL1 PKN2 ATP11A FGD5 MAPK1	3.24e-03	880	140	11	EFO_0007978
Disease	Sarcomatoid Renal Cell Carcinoma	SHANK1 DAPK1 EEF2 PAK1	3.29e-03	128	140	4	C1266043
Disease	Chromophobe Renal Cell Carcinoma	SHANK1 DAPK1 EEF2 PAK1	3.29e-03	128	140	4	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	SHANK1 DAPK1 EEF2 PAK1	3.29e-03	128	140	4	C1266044
Disease	Papillary Renal Cell Carcinoma	SHANK1 DAPK1 EEF2 PAK1	3.29e-03	128	140	4	C1306837
Disease	Renal Cell Carcinoma	SHANK1 DAPK1 EEF2 PAK1	3.29e-03	128	140	4	C0007134
Disease	Schizophrenia	SHANK1 ANK3 BACE1 IDE GRIN2C CHGB CSMD2 ADSS2 PAK2 MAPK1 TPI1	3.33e-03	883	140	11	C0036341
Disease	transitional cell carcinoma (is_marker_for)	CA9 REL PAK1	3.37e-03	63	140	3	DOID:2671 (is_marker_for)
Disease	mean platelet volume	TTC28 KALRN PCDHGA4 SPTA1 BACE1 ACTN4 BCLAF3 RRAGA GLS ANKDD1A PRDM16 NIN	3.47e-03	1020	140	12	EFO_0004584
Disease	renal cell carcinoma (is_implicated_in)	CA9 PAK1 MAPK1	4.36e-03	69	140	3	DOID:4450 (is_implicated_in)
Disease	Infiltrating duct carcinoma of female breast	TRPM7 PKN1	4.42e-03	21	140	2	C3165106

Protein segments in the cluster

Peptide	Gene	Start	Entry
GVEHVHRDAEVLFVG	ZNF280A	36	P59817
AHGVEFVERKDLIHS	AKAP14	96	Q86UN6
EELEAHFSRCGEVHR	PABPN1L	161	A6NDY0
AEDLARSEQHEHVAG	DAPK1	646	P53355
HVHDEFRTAAVEGPF	BACE1	421	P56817
ARAHSVAHAGLEFLA	BAHCC1	1056	Q9P281
GLHFLVFDTEEVHDV	CSMD2	1311	Q7Z408
FLEHFTHARVEAGQA	CCNO	236	P22674
HTACIIDVFGVTHRE	HSD3B1	81	P14060
AVIHHFATAERRVAA	ALKBH8	471	Q96BT7
VIEDDGLHAAFTVAH	ADAMTS5	396	Q9UNA0
AAGTDEVRVFHAHRL	BTBD17	71	A6NE02
EHVLRQVDVTSFAGH	AGRN	1806	O00468
HEAFESDLAAHQDRV	ACTN4	456	O43707
EDIAAHTVHTVDGQF	C13orf42	211	A0A1B0GVH6
EGVHYIADHLRSEDA	CHRNA2	471	Q15822
AGREGNLIAIFHEEH	DNMBP	1211	Q6XZF7
HIAAAAGFSDIIHEL	ANKRD55	236	Q3KP44
ELESHTDAHLGRDFF	CAPN8	441	A6NHC0
SEHIVDGVSYAAELH	CA13	106	Q8N1Q1
HDGFLLEVHRESLGD	CEP76	161	Q8TAP6
ADFHEDVIHSGSALL	CELSR1	2181	Q9NYQ6
VVDDSVVRFHGKEHV	ADAMTS14	266	Q8WXS8
EHHDHVVFLTRQDFG	ADAMTS14	351	Q8WXS8
HVVHLSTAFARVDEA	CA9	251	Q16790
VRDHAGASALVHALD	ANKRD34A	106	Q69YU3
EYHSGHIDRAFDIIE	NUP93	701	Q8N1F7
DTAVLAHETHRDSGF	R3HCC1L	351	Q7Z5L2
GRDIAEHTHDQVVLF	PTPN4	571	P29074
SRTALHVAAAEGHVE	GLS	586	O94925
GEADVHFETHEDAVA	GRSF1	441	Q12849
DLESGAHLTHFLFRE	CYP27B1	286	O15528
EAVHHLVLTAFDGGD	PCDHGA4	236	Q9Y5G9
ARVADPDHDHTGFLT	MAPK1	171	P28482
FEHTIHVGFDAVTGE	PAK3	76	O75914
VFEETGISHSEFLHR	TRIT1	191	Q9H3H1
RGTFSLVIHAVHEED	MYLK	86	Q15746
HVVADAGAFLRHAAL	NOB1	6	Q9ULX3
RGVAFNHEGHLVVTD	TRIM71	751	Q2Q1W2
AFAASEGHSHPRVVE	LIN7A	96	O14910
AFAASEGHSHPRVVE	LIN7C	81	Q9NUP9
GAGHHVRLEERFSDD	MAFA	216	Q8NHW3
HARDGTHRFFVAEQV	HHIPL1	201	Q96JK4
AHEFGAITFVDEVHA	ALAS1	401	P13196
QARHVHILGFSEEER	NLRP10	306	Q86W26
AHHDVARLTAFSEVG	HMCN2	4976	Q8NDA2
VEVTGHAHVLLAAFE	MGRN1	211	O60291
EDTEGVHEVFSRNHA	HSPH1	411	Q92598
DDFSIHAAHVVCREL	LOXL2	86	Q9Y4K0
FTEEEIEFLEARGHH	GGT7	611	Q9UJ14
VADVFLAREQGFDHH	FGD5	976	Q6ZNL6
AAFHHSVEIRERLGV	FGD5	1216	Q6ZNL6
ASADAVVFHHRELQT	FUT7	86	Q11130
HEVVFAFVTDEHAQG	GCGR	361	P47871
DSFVEKGHIHATEIR	KALRN	1196	O60229
VVGHNVSFDRAHIRE	POLG	266	P54098
RDRHFGFHVVLAEDA	KIF7	51	Q2M1P5
PALTDAAAEAHHIRF	KANSL1	6	Q7Z3B3
TDHEIAHNLFVTRGA	GDPGP1	281	Q6ZNW5
HVAGFTVAHDVSARD	FAHD2A	181	Q96GK7
HDNAHVEGSELSFEV	RALGAPA2	1406	Q2PPJ7
GFVHFETHEAAERAI	PABPC3	141	Q9H361
DLASHGFIVAAVEHR	PLA2G7	166	Q13093
VHHAAFGDEGAVIEV	MIB1	501	Q86YT6
TAFDGFHIHIEREEN	PTPRO	356	Q16827
FEHTIHVGFDAVTGE	PAK1	81	Q13153
GSAVLVFDIHVIDFH	FKBP9	351	O95302
DSEHHEDFEFISGTR	PAPSS1	576	O43252
EHTIHVGFDAVTGEF	PAK2	81	Q13177
AGFSIHVEISRAHEI	DNAH1	961	Q9P2D7
HHFESVCLDAEVRVV	FER1L6-AS2	11	Q96M78
EHIFHIASAAERDDQ	BCLAF3	571	A2AJT9
GDEAIGVRHFAAHER	CCDC149	81	Q6ZUS6
GVRHFAAHEREDLVQ	CCDC149	86	Q6ZUS6
SHVIIGEDHSRVADF	LIG4	861	P49917
HVAGFTVAHDVSARD	FAHD2B	181	Q6P2I3
RHLGFSDVSHDAARV	COL20A1	561	Q9P218
DFEAGHRSFHLIVEV	CDHR3	196	Q6ZTQ4
HHAGLTFEERDIIEG	POLQ	416	O75417
IHGTEDEVIDFSHGL	ABHD17C	271	Q6PCB6
EQAEAEHAEATHRRA	APBA1	131	Q02410
LHLSAREGHEDVAAF	ANK3	536	Q12955
REGHEDVAAFLLDHG	ANK3	541	Q12955
FILSFIDHIAGDEDH	KPNB1	796	Q14974
DRVAVHHAEAEALAR	MBLAC2	96	Q68D91
HHAEAEALARGDNFE	MBLAC2	101	Q68D91
EELNVFHERGASIAH	GDA	286	Q9Y2T3
FDVSHEHLEGALDRF	IDE	151	P14735
RFDVHDVTLHADAIH	EEF2	701	P13639
ESTDAHHERTFIGIF	EMC1	746	Q8N766
IGVVVGHELTHAFDD	ECE1	601	P42892
STVADHFDHIRAVIG	DPEP3	336	Q9H4B8
RHIRHGDVIACDVEA	DGLUCY	496	Q7Z3D6
RGGEEALHAFLLVHS	HPS1	201	Q92902
EELVARSETHAAGHS	CHGB	211	P05060
VNESTGEAFRLHHVE	GARNL3	681	Q5VVW2
RAGGVHHDIDFCIAR	KIF2B	626	Q8N4N8
LVDFVVTHFGNHEDD	CWH43	541	Q9H720
LHHGDFSAEEVFHRE	TMEM43	286	Q9BTV4
RAGEEIHFHFSKVID	RPGRIP1	1166	Q96KN7
ASEVDDHHAAIERRN	NIN	401	Q8N4C6
HVSAKVGTRLVFDHD	PMS2P2	191	O95744
HDHSRFGILEFISLA	FGF16	86	O43320
AVGFDHTRRCAEDHE	PRDM16	1166	Q9HAZ2
RKTGVHDADFEAHII	ST3GAL2	321	Q16842
TFDHILAAVEDVVGH	SLC9A5	476	Q14940
HFRVEHAVAEGAKNV	PKN1	221	Q16512
DRAHIVFDFHQAADG	ADSS2	131	P30520
VALQGAEHHEAVEAL	SCRIB	786	Q14160
AEHHEAVEALRGAGT	SCRIB	791	Q14160
HLRGVFDESVRAHLA	INTS5	76	Q6P9B9
EESHLTGAVEHEAAR	KIAA0753	596	Q2KHM9
ELRHHFRIEFAVAEG	PKN2	221	Q16513
NEAALHAAREGHTSV	SPG7	526	Q9UQ90
IVNSHLAAHVEDFER	OCRL	371	Q01968
EFGAHLASFAHIEEE	PLA2R1	701	Q13018
LVGRVFVHTLDHETF	SGCA	31	Q16586
ARSDSAHQIDEVLHF	SERPINB12	46	Q96P63
GLAEHRAQFLDHEID	SHANK1	2111	Q9Y566
TAFHRAAEHGQLDAL	ANKDD1A	161	Q495B1
HEAFESDLAAHQDRV	ACTN3	451	Q08043
SDLAAHQDRVEHIAA	ACTN3	456	Q08043
EHVFRHAARELFGIH	CIAO3	321	Q9H6Q4
HAARELFGIHVAEVT	CIAO3	326	Q9H6Q4
FHTEEDIGGLHATIE	ATP11A	201	P98196
RHERHHIGDFSFQEI	ZNF525	76	Q8N782
HHSRAEEEAAVVAAS	TNRC18	531	O15417
HLVVERSDDGSFHIR	UHRF1BP1L	1346	A0JNW5
HRDLHAVDVFSVEGA	ZNF618	206	Q5T7W0
LQFDVETRHVFIGDH	WDFY2	161	Q96P53
ASLVGHEFERVIDQH	RILPL1	31	Q5EBL4
HEFERVIDQHGCEAI	RILPL1	36	Q5EBL4
ATIDVEHSHVRFLGN	RRAGA	41	Q7L523
SAHEVQRFHRDADET	SPTAN1	1231	Q13813
HQEHRTEIDARAGTF	SPTAN1	1381	Q13813
AEVAAFHLDRILGFH	FAM20B	146	O75063
HVGLTFQAFEIERHD	TLL2	501	Q9Y6L7
HSERRHVFGESDELI	TPI1	96	P60174
SSDHEAVNGILHFID	STAB1	1691	Q9NY15
DHVETGFRHVDQDGL	REL	306	Q04864
AESFHRVHTAFEREL	SPTB	1831	P11277
SAHAVEVFHREADDT	SPTA1	1181	P02549
HEALENDFAVHETRV	SPTA1	1861	P02549
VLHRAHFSADAAVVV	TTC17	271	Q96AE7
HFSADAAVVVHAALD	TTC17	276	Q96AE7
HAAFHQIEAVDGEEL	RABAC1	166	Q9UI14
SLGHHDEALAVAERG	TTC28	1181	Q96AY4
LTHNHIEVVEDGAFD	TPBGL	101	P0DKB5
AGFHRGEQEDAHEFL	USP17L7	151	P0C7H9
VEAADSAHIVAHAAV	TTC23	266	Q5W5X9
EVDGEHFLAVANHRE	TSPEAR	431	Q8WU66
DRFTDITLIVDGHHF	ZNF131	31	P52739
LLAHAFFREERGVHV	WNK4	426	Q96J92
VEFHEHRHAAAALAA	TIA1	51	P31483
FHIGSDEHQDIDVAI	TRPM7	381	Q96QT4
HLEFHGDRIIFANVS	TM9SF1	166	O15321
VTDGGHLELAVFHET	PRKCH	76	P24723
FGERIASHDDRFLLH	N4BP1	696	O75113
GAAHVHGIVFEDNVD	GRIN2C	86	Q14957