Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transforming growth factor beta receptor activity, type II	TGFBR2 AMHR2	1.67e-05	2	82	2	GO:0005026
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	TGFBR2 AMHR2 NTRK3 LTK ACVR2A	2.62e-05	85	82	5	GO:0019199
GeneOntologyMolecularFunction	transketolase activity	TKTL1 TKTL2	4.98e-05	3	82	2	GO:0004802
GeneOntologyMolecularFunction	transmembrane receptor protein serine/threonine kinase activity	TGFBR2 AMHR2 ACVR2A	7.24e-05	20	82	3	GO:0004675
GeneOntologyMolecularFunction	transketolase or transaldolase activity	TKTL1 TKTL2	1.65e-04	5	82	2	GO:0016744
GeneOntologyMolecularFunction	thiamine pyrophosphate binding	TKTL1 TKTL2	4.59e-04	8	82	2	GO:0030976
GeneOntologyMolecularFunction	activin receptor activity	TGFBR2 ACVR2A	5.89e-04	9	82	2	GO:0017002
GeneOntologyMolecularFunction	activin binding	TGFBR2 ACVR2A	1.07e-03	12	82	2	GO:0048185
GeneOntologyMolecularFunction	transforming growth factor beta receptor activity	TGFBR2 AMHR2	1.26e-03	13	82	2	GO:0005024
Domain	KRAB	ZNF729 ZNF708 ZNF311 ZNF43 ZNF728 ZNF429 ZNF208 ZNF565 ZNF582 ZNF286A	3.31e-06	358	81	10	PS50805
Domain	KRAB	ZNF729 ZNF708 ZNF311 ZNF43 ZNF728 ZNF429 ZNF208 ZNF565 ZNF582 ZNF286A	3.31e-06	358	81	10	PF01352
Domain	KRAB	ZNF729 ZNF708 ZNF311 ZNF43 ZNF728 ZNF429 ZNF208 ZNF565 ZNF582 ZNF286A	4.33e-06	369	81	10	SM00349
Domain	KRAB	ZNF729 ZNF708 ZNF311 ZNF43 ZNF728 ZNF429 ZNF208 ZNF565 ZNF582 ZNF286A	4.44e-06	370	81	10	IPR001909
Domain	TGFB_receptor	TGFBR2 AMHR2 ACVR2A	1.68e-05	12	81	3	IPR000333
Domain	TRANSKETOLASE_1	TKTL1 TKTL2	5.56e-05	3	81	2	PS00801
Domain	TRANSKETOLASE_2	TKTL1 TKTL2	5.56e-05	3	81	2	PS00802
Domain	Transketolase_N	TKTL1 TKTL2	5.56e-05	3	81	2	PF00456
Domain	Transketolase_N	TKTL1 TKTL2	5.56e-05	3	81	2	IPR005474
Domain	zf-C2H2_6	ZNF729 ZNF311 ZNF43 ZNF728 ZNF429 ZNF208 ZNF582 ZNF286A	6.47e-05	314	81	8	PF13912
Domain	PHR	BTBD2 BTBD3	1.84e-04	5	81	2	PF08005
Domain	Transketo_C/PFOR_II	TKTL1 TKTL2	1.84e-04	5	81	2	IPR009014
Domain	Transketolase_C	TKTL1 TKTL2	1.84e-04	5	81	2	IPR033248
Domain	Transketolase_fam	TKTL1 TKTL2	1.84e-04	5	81	2	IPR033247
Domain	PHR	BTBD2 BTBD3	1.84e-04	5	81	2	IPR012983
Domain	Transketolase_C	TKTL1 TKTL2	1.84e-04	5	81	2	PF02780
Domain	-	TKTL1 TKTL2	1.84e-04	5	81	2	3.40.50.920
Domain	zf-C2H2	ZNF729 ZNF708 ZNF311 PHF20 ZNF43 ZNF728 ZNF429 ZNF208 ZNF565 ZNF582 ZNF286A	1.93e-04	693	81	11	PF00096
Domain	ZINC_FINGER_C2H2_2	ZNF729 ZNF708 ZNF311 PHF20 ZNF43 ZNF728 ZNF429 ZNF208 ZNF565 ZNF582 ZNF286A	5.01e-04	775	81	11	PS50157
Domain	Transket_pyr	TKTL1 TKTL2	5.11e-04	8	81	2	SM00861
Domain	Transket_pyr	TKTL1 TKTL2	5.11e-04	8	81	2	PF02779
Domain	DHC_N1	DNAH2 DNAH9	5.11e-04	8	81	2	PF08385
Domain	Transketolase-like_Pyr-bd	TKTL1 TKTL2	5.11e-04	8	81	2	IPR005475
Domain	Dynein_heavy_dom-1	DNAH2 DNAH9	5.11e-04	8	81	2	IPR013594
Domain	ZINC_FINGER_C2H2_1	ZNF729 ZNF708 ZNF311 PHF20 ZNF43 ZNF728 ZNF429 ZNF208 ZNF565 ZNF582 ZNF286A	5.12e-04	777	81	11	PS00028
Domain	Znf_C2H2-like	ZNF729 ZNF708 ZNF311 PHF20 ZNF43 ZNF728 ZNF429 ZNF208 ZNF565 ZNF582 ZNF286A	6.26e-04	796	81	11	IPR015880
Domain	Znf_C2H2	ZNF729 ZNF708 ZNF311 PHF20 ZNF43 ZNF728 ZNF429 ZNF208 ZNF565 ZNF582 ZNF286A	6.87e-04	805	81	11	IPR007087
Domain	-	ZNF729 ZNF708 ZNF311 ZNF43 ZNF728 ZNF429 ZNF208 ZNF565 ZNF582 ZNF286A	6.92e-04	679	81	10	3.30.160.60
Domain	ZnF_C2H2	ZNF729 ZNF708 ZNF311 PHF20 ZNF43 ZNF728 ZNF429 ZNF208 ZNF565 ZNF582 ZNF286A	7.09e-04	808	81	11	SM00355
Domain	Activin_recp	AMHR2 ACVR2A	8.17e-04	10	81	2	IPR000472
Domain	Activin_recp	AMHR2 ACVR2A	8.17e-04	10	81	2	PF01064
Domain	Znf_C2H2/integrase_DNA-bd	ZNF729 ZNF708 ZNF311 ZNF43 ZNF728 ZNF429 ZNF208 ZNF565 ZNF582 ZNF286A	8.18e-04	694	81	10	IPR013087
Domain	Tyr_kinase_rcpt_2_CS	NTRK3 LTK	9.96e-04	11	81	2	IPR002011
Domain	RECEPTOR_TYR_KIN_II	NTRK3 LTK	1.19e-03	12	81	2	PS00239
Domain	THDP-binding	TKTL1 TKTL2	1.40e-03	13	81	2	IPR029061
Domain	-	TKTL1 TKTL2	1.40e-03	13	81	2	3.40.50.970
Domain	Dynein_heavy_chain_D4_dom	DNAH2 DNAH9	1.63e-03	14	81	2	IPR024317
Domain	Dynein_HC_stalk	DNAH2 DNAH9	1.63e-03	14	81	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH2 DNAH9	1.63e-03	14	81	2	IPR013602
Domain	DHC_N2	DNAH2 DNAH9	1.63e-03	14	81	2	PF08393
Domain	MT	DNAH2 DNAH9	1.63e-03	14	81	2	PF12777
Domain	AAA_8	DNAH2 DNAH9	1.63e-03	14	81	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH2 DNAH9	1.63e-03	14	81	2	IPR011704
Domain	AAA_5	DNAH2 DNAH9	1.63e-03	14	81	2	PF07728
Domain	DHC_fam	DNAH2 DNAH9	1.88e-03	15	81	2	IPR026983
Domain	Dynein_heavy_dom	DNAH2 DNAH9	1.88e-03	15	81	2	IPR004273
Domain	Dynein_heavy	DNAH2 DNAH9	1.88e-03	15	81	2	PF03028
Domain	BACK	BTBD2 KLHL33 BTBD3	2.25e-03	60	81	3	SM00875
Domain	BACK	BTBD2 KLHL33 BTBD3	2.36e-03	61	81	3	PF07707
Domain	BACK	BTBD2 KLHL33 BTBD3	2.36e-03	61	81	3	IPR011705
Domain	Kinase-like_dom	TGFBR2 AMHR2 PIK3CD NTRK3 IRAK1 LTK ACVR2A CDC42BPB	2.40e-03	542	81	8	IPR011009
Domain	PROTEIN_KINASE_ATP	TGFBR2 AMHR2 NTRK3 IRAK1 LTK ACVR2A CDC42BPB	3.76e-03	459	81	7	PS00107
Domain	Spectrin	SPTAN1 SYNE2	4.43e-03	23	81	2	PF00435
Domain	Prot_kinase_dom	TGFBR2 AMHR2 NTRK3 IRAK1 LTK ACVR2A CDC42BPB	5.30e-03	489	81	7	IPR000719
Domain	PROTEIN_KINASE_DOM	TGFBR2 AMHR2 NTRK3 IRAK1 LTK ACVR2A CDC42BPB	5.54e-03	493	81	7	PS50011
Domain	Spectrin_repeat	SPTAN1 SYNE2	6.99e-03	29	81	2	IPR002017
Domain	PSI	MEGF8 PLXND1	8.47e-03	32	81	2	PF01437
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF729 ZNF43 ZNF429 ZNF208	4.23e-08	15	84	4	15885501
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF729 ZNF43 ZNF429 ZNF208	7.18e-07	29	84	4	14563677
Pubmed	A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function.	LOXHD1 CDH23 ADGRV1	1.61e-06	10	84	3	17329413
Pubmed	Functional analysis of the SRY-KRAB interaction in mouse sex determination.	ZNF729 ZNF43 ZNF208	1.61e-06	10	84	3	18588511
Pubmed	Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.	ZNF729 ZNF43 ZNF208	2.21e-06	11	84	3	15469996
Pubmed	Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.	ZNF729 ZNF43 ZNF208	3.82e-06	13	84	3	19850934
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF708 ZNF311 RMND5A ZNF728 ZNF724 ZNF208	5.31e-06	181	84	6	37372979
Pubmed	Nuclear α Spectrin Differentially Affects Monoubiquitinated Versus Non-Ubiquitinated FANCD2 Function After DNA Interstrand Cross-Link Damage.	FANCD2 SPTAN1	5.76e-06	2	84	2	26297932
Pubmed	Mutation rates of TGFBR2 and ACVR2 coding microsatellites in human cells with defective DNA mismatch repair.	TGFBR2 ACVR2A	5.76e-06	2	84	2	18941508
Pubmed	The Mass1frings mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC.	CDH23 ADGRV1	5.76e-06	2	84	2	15820310
Pubmed	Expression of CDKN1A/p21 and TGFBR2 in breast cancer and their prognostic significance.	CDKN1A TGFBR2	5.76e-06	2	84	2	26823785
Pubmed	The human transketolase-like proteins TKTL1 and TKTL2 are bona fide transketolases.	TKTL1 TKTL2	5.76e-06	2	84	2	30646877
Pubmed	Mesalazine reduces mutations in transforming growth factor beta receptor II and activin type II receptor by improvement of replication fidelity in mononucleotide repeats.	TGFBR2 ACVR2A	5.76e-06	2	84	2	20197483
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF729 ZNF43 ZNF429 ZNF208	6.17e-06	49	84	4	9630514
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	FANCD2 CDKN1A GEMIN4 BEND3 PWWP3A RFX1 TOP3A CCNC	1.43e-05	453	84	8	29656893
Pubmed	DNA topoisomerase III alpha regulates p53-mediated tumor suppression.	CDKN1A TOP3A	1.73e-05	3	84	2	24526736
Pubmed	Influence of target gene mutations on survival, stage and histology in sporadic microsatellite unstable colon cancers.	TGFBR2 ACVR2A	1.73e-05	3	84	2	16380996
Pubmed	EGFR and SYNE2 are associated with p21 expression and SYNE2 variants predict post-operative clinical outcomes in HBV-related hepatocellular carcinoma.	CDKN1A SYNE2	1.73e-05	3	84	2	27502069
Pubmed	Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3).	CDKN1A CCNC	3.45e-05	4	84	2	7698009
Pubmed	Interaction of protocadherin-15 with the scaffold protein whirlin supports its anchoring of hair-bundle lateral links in cochlear hair cells.	CDH23 ADGRV1	3.45e-05	4	84	2	33009420
Pubmed	FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex.	FANCD2 TOP3A	3.45e-05	4	84	2	25659033
Pubmed	TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence.	TGFBR2 ACVR2A	3.45e-05	4	84	2	27696331
Pubmed	Identification and analysis of type II TGF-β receptors in BMP-9-induced osteogenic differentiation of C3H10T1/2 mesenchymal stem cells.	TGFBR2 ACVR2A	3.45e-05	4	84	2	20801928
Pubmed	Role for a novel Usher protein complex in hair cell synaptic maturation.	CDH23 ADGRV1	3.45e-05	4	84	2	22363448
Pubmed	Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors.	TGFBR2 ACVR2A	5.74e-05	5	84	2	16982625
Pubmed	A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor.	TGFBR2 ACVR2A	5.74e-05	5	84	2	8389764
Pubmed	Tumor-infiltrating lymphocytes in colorectal cancers with microsatellite instability are correlated with the number and spectrum of frameshift mutations.	TGFBR2 ACVR2A	5.74e-05	5	84	2	19503063
Pubmed	Adaptive immune defects against glycoantigens in chronic granulomatous disease via dysregulated nitric oxide production.	CYBB CDH23	5.74e-05	5	84	2	21630251
Pubmed	Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif.	FANCD2 CDKN1A	5.74e-05	5	84	2	19704162
Pubmed	Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module.	CDKN1A TGFBR2 AMHR2 ACVR2A CCNC	7.20e-05	177	84	5	22560297
Pubmed	CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components.	RSPH4A DNAH9	8.59e-05	6	84	2	33347437
Pubmed	Feedback between p21 and reactive oxygen production is necessary for cell senescence.	CDKN1A TGFBR2	8.59e-05	6	84	2	20160708
Pubmed	Activation of signalling by the activin receptor complex.	TGFBR2 ACVR2A	8.59e-05	6	84	2	8622651
Pubmed	Smad4-Irf6 genetic interaction and TGFβ-mediated IRF6 signaling cascade are crucial for palatal fusion in mice.	CDKN1A TGFBR2	8.59e-05	6	84	2	23406900
Pubmed	TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation.	TGFBR2 ACVR2A	8.59e-05	6	84	2	11483955
Pubmed	TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells.	LOXHD1 CDH23	8.59e-05	6	84	2	23217710
Pubmed	Insulin-like Growth Factor 1, Growth Hormone, and Anti-Müllerian Hormone Receptors Are Differentially Expressed during GnRH Neuron Development.	AMHR2 PLXND1	8.59e-05	6	84	2	37685880
Pubmed	Biochemical characterization of native Usher protein complexes from a vesicular subfraction of tracheal epithelial cells.	CDH23 ADGRV1	1.20e-04	7	84	2	20058854
Pubmed	CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks.	CYBB PIK3CD	1.20e-04	7	84	2	18755982
Pubmed	Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.	DNAH2 DNAH9	1.20e-04	7	84	2	31178125
Pubmed	Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects.	CDKN1A TGFBR2	1.20e-04	7	84	2	12975342
Pubmed	The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1β transcription and processing in monocytes.	CYBB IRAK1	1.60e-04	8	84	2	26320741
Pubmed	Specificity of monosynaptic sensory-motor connections imposed by repellent Sema3E-PlexinD1 signaling.	NTRK3 PLXND1	1.60e-04	8	84	2	24210822
Pubmed	Microarray-based mutation analysis of 183 Spanish families with Usher syndrome.	CDH23 ADGRV1	1.60e-04	8	84	2	19683999
Pubmed	Anti-Mullerian-hormone-dependent regulation of the brain serine-protease inhibitor neuroserpin.	TGFBR2 AMHR2	1.60e-04	8	84	2	18796535
Pubmed	Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors.	TGFBR2 ACVR2A	1.60e-04	8	84	2	8242742
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	DCAF13 UBXN7 GEMIN4 RNF213 PRPF6 RFX1	1.82e-04	341	84	6	32971831
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DCAF13 SPTAN1 SYNE2 GEMIN4 BEND3 PRPF6 NUP160 XPO7	1.84e-04	653	84	8	22586326
Pubmed	Identification of interleukin 1 receptor-associated kinase as a conserved component in the p75-neurotrophin receptor activation of nuclear factor-kappa B.	NTRK3 IRAK1	2.05e-04	9	84	2	12034707
Pubmed	Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction.	CDH23 ADGRV1	2.05e-04	9	84	2	28705869
Pubmed	The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities.	NTRK3 LTK	2.05e-04	9	84	2	12237455
Pubmed	Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells.	TGFBR2 ACVR2A	2.05e-04	9	84	2	19366699
Pubmed	Massively parallel DNA sequencing facilitates diagnosis of patients with Usher syndrome type 1.	CDH23 ADGRV1	2.56e-04	10	84	2	24618850
Pubmed	Usher protein functions in hair cells and photoreceptors.	CDH23 ADGRV1	2.56e-04	10	84	2	24239741
Pubmed	Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1.	TGFBR2 ACVR2A	2.56e-04	10	84	2	15611116
Pubmed	Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke.	IMPA2 UBR3	3.13e-04	11	84	2	19910543
Pubmed	Strain background effects and genetic modifiers of hearing in mice.	CDH23 ADGRV1	3.13e-04	11	84	2	16579977
Pubmed	Specificity of sensory-motor connections encoded by Sema3e-Plxnd1 recognition.	NTRK3 PLXND1	3.13e-04	11	84	2	19421194
Pubmed	Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily.	TGFBR2 ACVR2A	3.13e-04	11	84	2	9872992
Pubmed	TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population.	TGFBR2 AMHR2 ACVR2A	3.26e-04	55	84	3	15342483
Pubmed	A novel ubiquitin ligase is deficient in Fanconi anemia.	FANCD2 TOP3A	3.75e-04	12	84	2	12973351
Pubmed	Identification of Smurf2 as a HIF-1α degrading E3 ubiquitin ligase.	DCAF13 TRIM37	3.75e-04	12	84	2	34611473
Pubmed	Generation of Cajal-Retzius neurons in mouse forebrain is regulated by transforming growth factor beta-Fox signaling pathways.	CDKN1A TGFBR2	3.75e-04	12	84	2	18005957
Pubmed	Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion.	TGFBR2 ACVR2A	3.75e-04	12	84	2	16806156
Pubmed	A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.	FANCD2 TOP3A	3.75e-04	12	84	2	16116422
Pubmed	Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development.	TGFBR2 ACVR2A	3.75e-04	12	84	2	23342175
Pubmed	TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.	TGFBR2 ACVR2A	5.15e-04	14	84	2	21791611
Pubmed	Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering.	ZNF708 ZNF43	5.15e-04	14	84	2	2014798
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	BEND3 RNF213 PWWP3A PLXND1 CDC42BPB NUP160 BTBD3 XPO7	5.86e-04	777	84	8	35844135
Pubmed	Active conformation of the p97-p47 unfoldase complex.	SPTAN1 UBXN7	5.93e-04	15	84	2	35552390
Pubmed	Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.	ZNF43 ZNF208	6.77e-04	16	84	2	8467795
Pubmed	Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.	CDH23 ADGRV1	6.77e-04	16	84	2	17567809
Pubmed	Akt/Nox2/NF-κB signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation.	CYBB PIK3CD	6.77e-04	16	84	2	21029719
Pubmed	Mouse development and cell proliferation in the absence of D-cyclins.	CDKN1A CCNC	6.77e-04	16	84	2	15315760
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	FANCD2 CDKN1A DNAJB12 RMND5A IMPA2 SPTAN1 SYNE2 GEMIN4 IRAK1 RNF213 PRPF6	6.85e-04	1440	84	11	30833792
Pubmed	Distinct nuclear and cytoplasmic assemblies and interactomes of the mammalian CTLH E3 ligase complex.	RMND5A BEND3 PRPF6 DMBT1	7.34e-04	167	84	4	35833506
Pubmed	Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors.	TGFBR2 ACVR2A	7.66e-04	17	84	2	17456004
Pubmed	A role for p75 neurotrophin receptor in the control of hair follicle morphogenesis.	TGFBR2 NTRK3	7.66e-04	17	84	2	10588868
Pubmed	Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.	FANCD2 CDKN1A AMHR2 ACVR2A	7.84e-04	170	84	4	19064572
Pubmed	Multiple lineage-specific roles of Smad4 during neural crest development.	TGFBR2 NTRK3	8.60e-04	18	84	2	19361496
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DNAJB12 ZNF708 IMPA2 KCNQ5 RASA2 ABHD2 RNF213 ADGRV1 GPT2 CDC42BPB XPO7	9.01e-04	1489	84	11	28611215
Pubmed	Biochemical and Cellular Analysis Reveals Ligand Binding Specificities, a Molecular Basis for Ligand Recognition, and Membrane Association-dependent Activities of Cripto-1 and Cryptic.	TGFBR2 ACVR2A	9.60e-04	19	84	2	28126904
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	DNAJB12 GEMIN4 RNF213 XPO7	1.03e-03	183	84	4	23956138
Pubmed	A molecular genetic linkage map of mouse chromosome 2.	SPTAN1 LTK	1.06e-03	20	84	2	1970329
Pubmed	Essential roles of G9a in cell proliferation and differentiation during tooth development.	CDKN1A CCNC	1.06e-03	20	84	2	28527696
Pubmed	A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.	FANCD2 TOP3A	1.06e-03	20	84	2	22705371
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	TMEM120A SPTAN1 UBXN7 RNF213 BTBD2 CAPN15	1.11e-03	481	84	6	28190767
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	SPTAN1 SYNE2 RNF213 NUP160	1.12e-03	187	84	4	26460568
Pubmed	ETAA1 acts at stalled replication forks to maintain genome integrity.	FANCD2 TOP3A	1.17e-03	21	84	2	27723720
Pubmed	Concomitant inactivation of foxo3a and fancc or fancd2 reveals a two-tier protection from oxidative stress-induced hydrocephalus.	FANCD2 CDKN1A	1.17e-03	21	84	2	24483844
Pubmed	Identification of cellular proteins required for replication of human immunodeficiency virus type 1.	NTRK3 CDH23	1.17e-03	21	84	2	22404213
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SYNE2 TRIM37 BTBD3	1.24e-03	87	84	3	12465718
Pubmed	E3 ubiquitin ligase NEURL3 promotes innate antiviral response through catalyzing K63-linked ubiquitination of IRF7.	FANCD2 IRAK1	1.29e-03	22	84	2	35792897
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MEGF8 PIK3CD IRAK1 PAPLN UNKL PLXND1 LTK CDC42BPB TOP3A	1.39e-03	1105	84	9	35748872
Pubmed	Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes.	GEMIN4 PRPF6	1.41e-03	23	84	2	20696395
Pubmed	Exploring the link between MORF4L1 and risk of breast cancer.	KPNA5 TOP3A	1.54e-03	24	84	2	21466675
Pubmed	Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor.	CDKN1A SPTAN1	1.67e-03	25	84	2	20696915
Pubmed	Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription.	CDKN1A GTF2A2	1.67e-03	25	84	2	25664857
Pubmed	Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice.	CYBB CDKN1A	1.67e-03	25	84	2	12829028
Pubmed	A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies.	CDKN1A MEGF8	1.95e-03	27	84	2	34242585
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF729 ZNF708 ZNF43 ZNF728 ZNF724 ZNF429 ZNF208	3.01e-09	122	84	7	chr19p12
Cytoband	19p12	ZNF729 ZNF708 ZNF728 ZNF724 ZNF208	7.07e-07	90	84	5	19p12
Cytoband	6q22.1	KPNA5 RSPH4A	1.30e-03	29	84	2	6q22.1
Cytoband	10q22.1	DNAJB12 CDH23	3.25e-03	46	84	2	10q22.1
Cytoband	19p13.1	ZNF429 RFX1	3.53e-03	48	84	2	19p13.1
GeneFamily	Type 2 receptor serine/threonine kinases	TGFBR2 AMHR2 ACVR2A	3.12e-07	5	58	3	346
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF729 ZNF708 ZNF311 ZNF43 ZNF728 ZNF429 ZNF208 ZNF565 ZNF582 ZNF286A	8.50e-05	718	58	10	28
GeneFamily	Dyneins, axonemal	DNAH2 DNAH9	1.33e-03	17	58	2	536
Coexpression	SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_DN	CDKN1A PHF20 PIK3CD UBXN7	3.30e-06	32	84	4	M740
ToppCell	PND07-28-samps-Myeloid-Macrophage-macrophage-A\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	TMEM120A IMPA2 RNF213 DMBT1 KLHL33	2.31e-06	112	84	5	d21cfcb04a27cc9fb74e0c2afa8a8cdfb886ae21
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Radial_glial-RGCs_3\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	RAD51AP2 NTRK3 VEPH1 TKTL1 TKTL2	5.97e-06	136	84	5	5e209185b5f6e9347829fc9066f0b2c3711df057
Disease	peripheral neuropathy	IMPA2 NTRK3	1.40e-04	7	77	2	EFO_0003100
Disease	Gastric Adenocarcinoma	TGFBR2 NTRK3 ACVR2A	2.24e-04	45	77	3	C0278701
Disease	Primary Ciliary Dyskinesia	SPAG1 RSPH4A DNAH9	2.55e-04	47	77	3	C4551720
Disease	Marfan syndrome (implicated_via_orthology)	TGFBR2 ACVR2A	2.98e-04	10	77	2	DOID:14323 (implicated_via_orthology)
Disease	cerebral cavernous malformation (implicated_via_orthology)	RNF213 CDC42BPB	3.64e-04	11	77	2	DOID:0060669 (implicated_via_orthology)
Disease	pancreatic ductal carcinoma (is_marker_for)	CDKN1A TGFBR2 NTRK3	5.51e-04	61	77	3	DOID:3587 (is_marker_for)
Disease	Replication Error Phenotype	TGFBR2 ACVR2A	6.90e-04	15	77	2	C1721098
Disease	Microsatellite Instability	TGFBR2 ACVR2A	6.90e-04	15	77	2	C0920269
Disease	DiGeorge syndrome (implicated_via_orthology)	TGFBR2 PLXND1	1.12e-03	19	77	2	DOID:11198 (implicated_via_orthology)
Disease	pulmonary hypertension (biomarker_via_orthology)	CYBB CDKN1A TGFBR2	1.21e-03	80	77	3	DOID:6432 (biomarker_via_orthology)
Disease	Nonsyndromic Deafness	LOXHD1 CDH23 ADGRV1	1.26e-03	81	77	3	C3711374
Disease	Bronchiectasis	RSPH4A PIK3CD	1.50e-03	22	77	2	C0006267
Disease	Lynch syndrome (is_implicated_in)	TGFBR2 ACVR2A	1.79e-03	24	77	2	DOID:3883 (is_implicated_in)
Disease	Tinnitus, wellbeing measurement	CDH23 DNAH9 CAPN15	2.05e-03	96	77	3	EFO_0007869, HP_0000360
Disease	response to norepinephrine-dopamine reuptake inhibitor	KCNQ5 ADGRV1	2.10e-03	26	77	2	EFO_0007870
Disease	hearing impairment	LOXHD1 CDH23 ADGRV1	2.17e-03	98	77	3	C1384666

Protein segments in the cluster

Peptide	Gene	Start	Entry
NLEAALECENWLENQ	ZNF286A	151	Q9HBT8
DEENCWALNVNELRR	GPT2	236	Q8TD30
CIQEARERWNFDFVT	CDKN1A	41	P38936
QAQQLAQELAWCVEQ	C8orf33	106	Q9H7E9
EEAGCQADVWALQLQ	APOF	96	Q13790
LVVEYANAICQWERN	ABHD2	396	P08910
ETQECLFFNANWEKD	ACVR2A	26	P27037
CWNSERNQFSFVLEV	ADGRV1	3531	Q8WXG9
FEAALNWAEVECQRQ	BTBD3	286	Q9Y2F9
SVDCLFDDRNVWFNI	CC2D2B	1246	Q6DHV5
EFRVVWLNCTDNDVG	CDH23	1011	Q9H251
FATCGQQVDIWDEQR	DCAF13	171	Q9NV06
CFGIWNLTQDRAQVE	AMHR2	61	Q16671
LERNENCTLQFEAAW	KPNA5	136	O15131
NFAILENANWEEAEC	RAD51AP2	366	Q09MP3
VQANNCVEANEWIDV	RASA2	686	Q15283
DMQEEEAWLQQCAQR	BEND3	461	Q5T5X7
EAWLQQCAQRINDEL	BEND3	466	Q5T5X7
KALWENIVAFCRENN	CAPN15	471	O75808
CVVQQKDARQWFAEL	CCNC	206	P24863
QEEFEAFVAARCWLA	KLHL33	131	A6NCF5
NGNCAREEEIWEFLN	MAGEB4	211	O15481
QLEQNFFNCSCDIRW	NTRK3	156	Q16288
RQFQDTLQECWDLDR	LRRC61	221	Q9BV99
ANLIQCVWRSYAADE	KCNQ5	371	Q9NR82
NCNRWLDANEDDNEI	LOXHD1	521	Q8IVV2
LRDCQWQAELQLAEC	LTK	386	P29376
FEAVWVNESVVRCDQ	PLXND1	796	Q9Y4D7
NAEEWLQCINVAVAQ	VEPH1	806	Q14D04
NDCRINQREVFWAGN	MEGF8	1976	Q7Z7M0
FREERDVLVNGDCQW	CDC42BPB	121	Q9Y5S2
DWCQFAALIVRDQTE	IRAK1	41	P51617
WEECFQAAVQLALRA	IMPA2	16	O14732
RQLLEECDVFNWDQV	GLYATL3	86	Q5SZD4
ECDVFNWDQVFQIQG	GLYATL3	91	Q5SZD4
NVEDDYIANLRNNCW	DNAJB12	316	Q9NXW2
EARLWCEVRQGAFQQ	HUS1B	51	Q8NHY5
FNVEWCVNARVNNSD	CYBB	121	P04839
AACDGVQQDQLWREL	C2orf50	61	Q96LR7
RCTAFDAEQQQFWEQ	DNAH9	1226	Q9NYC9
LLLWAAACAQQEQDF	GPX7	11	Q96SL4
VVRWSEAECQRQQLQ	BTBD2	286	Q9BX70
DYWDTNDANVVCRQL	DMBT1	261	Q9UGM3
DDYWDTNDANVVCRQ	DMBT1	1406	Q9UGM3
DYWDTNDANVVCRQL	DMBT1	1536	Q9UGM3
WGCFDEFNRINIEVL	DNAH2	1851	Q9P225
NWFREIVNAFCQETS	FANCD2	791	Q9BXW9
EFQINEQVLACWSDC	PHF20	86	Q9BVI0
QAREDFNQDIGWCVS	PWWP3A	476	Q2TAK8
ENQEVARWVFFCQLC	PIGB	166	Q92521
LAQFLSWDDCRLQNQ	RTL5	261	Q5HYW3
RCNWFNSIQKNEEEE	RSPH4A	556	Q5TD94
RELVNCRWAEEVTQQ	TRIM37	61	O94972
RFCDNVWTFVLNDVE	GTF2A2	66	P52657
ANQWADICDIFTRDA	RMND5A	256	Q9H871
QNEKDNCEAFQEQVW	SYNE2	3186	Q8WXH0
DCLRDWEDLQQDFQN	TMEM120A	11	Q9BXJ8
VDFANVQEQASWVCR	RFX1	781	P22670
INREQWIQDAEECDR	PRPF6	501	O94906
WVQDNIRAAQDLCEE	PRPF6	686	O94906
QEVCVAVWRKNDENI	TGFBR2	81	P37173
SQEEFRNLQQEFWCK	NUP160	516	Q12769
VDFKAFEEQLQSWCQ	ACY1	281	Q03154
CENRLDWKEQESLNF	SPG11	1866	Q96JI7
LEWLAREACNQDALQ	RNF213	3601	Q63HN8
RQQKDQWFSCDDAII	USP51	671	Q70EK9
RADWECEGQFERQVN	ZNF565	156	Q8N9K5
EEWQCLDTAQQNLYR	ZNF724	16	A8MTY0
TACFANWQEAAEVLD	NXNL1	146	Q96CM4
TCVAFNGQDRDQRWV	PAPLN	1111	O95428
ELQLFHRDCEQAENW	SPTAN1	1446	Q13813
DVEALCQAFWQASQV	TKTL2	221	Q9H0I9
AEIKLQNWNSAFQDC	SPAG1	251	Q07617
QNWNSAFQDCEKVLE	SPAG1	256	Q07617
FRDVAIQFSLEEWQC	ZNF728	6	P0DKX0
EEWQCLDTAQQNLYR	ZNF728	16	P0DKX0
FCEEAAARRQQLGWE	PIK3CD	146	O00329
REQQCGFFQWVDENT	TOP3A	926	Q13472
VKQVCDAWQREAQEA	UNKL	591	Q9H9P5
SSFQDDWECRNQFDR	ZNF582	116	Q96NG8
EEWQCLDIAQQNLYR	ZNF43	16	P17038
EEWQCLDTAQQNLYR	ZNF708	16	P17019
EEWQCLDTAQQNLYR	ZNF208	16	O43345
CLEALQDWFDAINFV	UBR3	606	Q6ZT12
VLNIIIFEDCRNQWS	XPO7	986	Q9UIA9
EEWQCLDTAQQNLYR	ZNF429	16	Q86V71
QDFACQCLNRDVWSN	UBXN7	176	O94888
DVEALCQVFWQASQV	TKTL1	191	P51854
FEDVAVNFTNREWQC	ZNF311	66	Q5JNZ3
EWQCLDTVQQNLYRD	ZNF729	26	A6NN14
QTLEANACREEYWLQ	GEMIN4	676	P57678
LAWERFRCNINCDED	NAGA	31	P17050
ADICNLWRNYDDIQD	NAGA	206	P17050