Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion binding	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 CASQ2 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 ADGRV1 SNTN CEMIP2 VCAN PCDHGC3	4.92e-09	749	100	19	GO:0005509
GeneOntologyMolecularFunction	tRNA-4-demethylwyosine synthase activity	TYW1B TYW1	2.48e-05	2	100	2	GO:0102521
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	PCDHA9 EMB PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	1.24e-14	187	98	15	GO:0007156
GeneOntologyBiologicalProcess	cell-cell adhesion via plasma-membrane adhesion molecules	PCDHA9 EMB PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 JAML FLRT3 PCDHGC3	1.17e-13	313	98	17	GO:0098742
GeneOntologyBiologicalProcess	cell-cell adhesion	PCDHA9 EMB PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 ADGRV1 JAML SERPINB8 FLRT3 PCDHGC3	6.33e-07	1077	98	19	GO:0098609
GeneOntologyCellularComponent	piP-body	TDRKH TDRD9	2.20e-04	5	99	2	GO:0071547
GeneOntologyCellularComponent	subapical complex	MPDZ PATJ	2.20e-04	5	99	2	GO:0035003
Domain	Cadherin_tail	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	3.41e-23	37	100	14	PF15974
Domain	Cadherin_CBD	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	3.41e-23	37	100	14	IPR031904
Domain	Cadherin_2	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	3.01e-19	65	100	14	PF08266
Domain	Cadherin_N	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	3.01e-19	65	100	14	IPR013164
Domain	Cadherin_CS	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	6.55e-16	109	100	14	IPR020894
Domain	CADHERIN_1	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	1.10e-15	113	100	14	PS00232
Domain	Cadherin	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	1.10e-15	113	100	14	PF00028
Domain	CADHERIN_2	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	1.25e-15	114	100	14	PS50268
Domain	-	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	1.25e-15	114	100	14	2.60.40.60
Domain	CA	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	1.42e-15	115	100	14	SM00112
Domain	Cadherin-like	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	1.61e-15	116	100	14	IPR015919
Domain	Cadherin	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	2.05e-15	118	100	14	IPR002126
Domain	Cadherin_C	PCDHA9 PCDHGA6 PCDHAC1 PCDHA7 PCDHGC3	2.89e-06	42	100	5	IPR032455
Domain	Cadherin_C_2	PCDHA9 PCDHGA6 PCDHAC1 PCDHA7 PCDHGC3	2.89e-06	42	100	5	PF16492
Domain	Calx_beta	FRAS1 ADGRV1 SLC8A3	8.18e-06	8	100	3	SM00237
Domain	Calx_beta	FRAS1 ADGRV1 SLC8A3	1.22e-05	9	100	3	IPR003644
Domain	Calx-beta	FRAS1 ADGRV1 SLC8A3	1.22e-05	9	100	3	PF03160
Domain	L27_2	MPDZ PATJ	2.84e-05	2	100	2	PF09045
Domain	tRNA_wybutosine-synth	TYW1B TYW1	2.84e-05	2	100	2	IPR013917
Domain	L27_2	MPDZ PATJ	2.84e-05	2	100	2	IPR015132
Domain	Wyosine_form	TYW1B TYW1	2.84e-05	2	100	2	PF08608
Domain	L27	MPDZ PALS1 PATJ	4.10e-05	13	100	3	SM00569
Domain	L27	MPDZ PALS1 PATJ	4.10e-05	13	100	3	PS51022
Domain	L27_dom	MPDZ PALS1 PATJ	4.10e-05	13	100	3	IPR004172
Domain	FLAVODOXIN_LIKE	TYW1B TYW1	7.78e-04	8	100	2	PS50902
Domain	Flavodoxin/NO_synth	TYW1B TYW1	7.78e-04	8	100	2	IPR008254
Domain	Flavdoxin-like	TYW1B TYW1	7.78e-04	8	100	2	IPR001094
Domain	Flavodoxin_1	TYW1B TYW1	7.78e-04	8	100	2	PF00258
Domain	rSAM	TYW1B TYW1	9.97e-04	9	100	2	IPR007197
Domain	Radical_SAM	TYW1B TYW1	9.97e-04	9	100	2	PF04055
Domain	Flavoprotein-like_dom	TYW1B TYW1	1.24e-03	10	100	2	IPR029039
Domain	-	TYW1B TYW1	1.24e-03	10	100	2	3.40.50.360
Domain	TUDOR	TDRKH TDRD9	2.48e-03	14	100	2	PF00567
Pubmed	Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.	PCDHA9 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1	8.25e-29	15	101	12	15640798
Pubmed	Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.	PCDHA9 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1	1.12e-27	17	101	12	29911975
Pubmed	Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.	PCDHA9 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	1.14e-27	24	101	13	24698270
Pubmed	CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.	PCDHA9 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1	3.34e-27	18	101	12	15570159
Pubmed	Genomic organization of the family of CNR cadherin genes in mice and humans.	PCDHA9 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1	3.34e-27	18	101	12	10662547
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHA9 PCDHGA6 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	1.69e-26	28	101	13	15347688
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	8.24e-24	57	101	14	32633719
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	1.08e-23	58	101	14	30377227
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	1.29e-22	68	101	14	11230163
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	3.09e-22	72	101	14	10380929
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	4.69e-22	74	101	14	10817752
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	8.58e-22	77	101	14	10835267
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	1.53e-21	80	101	14	10716726
Pubmed	Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.	PCDHA9 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4	6.24e-19	11	101	8	9655502
Pubmed	The DNA sequence and comparative analysis of human chromosome 5.	PCDHA9 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1	2.97e-16	75	101	11	15372022
Pubmed	Proteins of the CNR family are multiple receptors for Reelin.	PCDHA9 PCDHA13 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4	1.10e-15	12	101	7	10612399
Pubmed	A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.	PCDHA9 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1	1.35e-15	119	101	12	28625976
Pubmed	Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.	PCDHA9 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 TSHR	1.68e-14	193	101	13	22589738
Pubmed	Common deletion variants causing protocadherin-α deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease.	PCDHA9 PCDHA12 PCDHA7	2.37e-07	5	101	3	34888534
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	PCDHA9 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA3 PCDHA2 PCDHA1	5.29e-07	329	101	9	17474147
Pubmed	Pals1/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Muller glia cells.	MPDZ PALS1 PATJ	8.25e-07	7	101	3	16885194
Pubmed	Asymmetric distribution of CRUMBS polarity complex proteins from compacted 8-cell to blastocyst stage during mouse preimplantation development.	MPDZ PALS1 PATJ	1.32e-06	8	101	3	29155075
Pubmed	Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR).	MAGED1 RPS6KB1 MAGED4	5.13e-06	12	101	3	22544753
Pubmed	Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes.	PALS1 PATJ	8.35e-06	2	101	2	15241471
Pubmed	PATJ and MPDZ are required for trophectoderm lineage specification in early mouse embryos.	MPDZ PATJ	8.35e-06	2	101	2	37318097
Pubmed	A Significant Difference in Core PDZ Interactivity of SARS-CoV, SARS-CoV2 and MERS-CoV Protein E Peptide PDZ Motifs In Vitro.	MPDZ PATJ	8.35e-06	2	101	2	36932261
Pubmed	Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs.	TYW1B TYW1	8.35e-06	2	101	2	16162496
Pubmed	Intron-less processed Pcdhalpha genes in the central nervous system.	PCDHA8 PCDHA6	8.35e-06	2	101	2	14697259
Pubmed	The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells.	MPDZ PALS1 PATJ	1.30e-05	16	101	3	18824598
Pubmed	A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells.	MPDZ PALS1 PATJ	1.57e-05	17	101	3	16678097
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	TDRKH SNAP47 CEMIP2 VPS13D SLC12A2 TYW1B FIG4 PDZD8 TYW1	1.68e-05	504	101	9	34432599
Pubmed	Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.	PCDHA9 EMB MPDZ PCDHA7 CEMIP2 SLC12A2 PLCL2 FLRT3	2.48e-05	405	101	8	38187761
Pubmed	The Crumbs complex: from epithelial-cell polarity to retinal degeneration.	PALS1 PATJ	2.50e-05	3	101	2	19625503
Pubmed	Two novel CNRs from the CNR gene cluster have molecular features distinct from those of CNR1 to 8.	PCDHA2 PCDHA1	2.50e-05	3	101	2	11401448
Pubmed	Identification of two novel PCDHA9 mutations associated with Hirschsprung's disease.	PCDHA9 PCDHA12	2.50e-05	3	101	2	29477871
Pubmed	The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost.	PALS1 PATJ	2.50e-05	3	101	2	11927608
Pubmed	The CRB1 Complex: Following the Trail of Crumbs to a Feasible Gene Therapy Strategy.	PALS1 PATJ	2.50e-05	3	101	2	28424578
Pubmed	Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1).	PALS1 PATJ	2.50e-05	3	101	2	12527193
Pubmed	Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins.	MPDZ PATJ	2.50e-05	3	101	2	19255144
Pubmed	Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells.	MPDZ PATJ	2.50e-05	3	101	2	12403818
Pubmed	The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8.	CASP8 GSDMC	2.50e-05	3	101	2	34012073
Pubmed	Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins.	PCDHA9 PCDHA7	2.50e-05	3	101	2	27161523
Pubmed	The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells.	PALS1 PATJ	2.50e-05	3	101	2	12771187
Pubmed	Usefulness of Exchanged Protein Directly Activated by cAMP (Epac)1-Inhibiting Therapy for Prevention of Atrial and Ventricular Arrhythmias in Mice.	RAPGEF4 CASQ2	2.50e-05	3	101	2	30518738
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	FRAS1 MAGED1 IPO8 NAP1L4 MRPL13 MPDZ EXT2 HEATR1 SNAP47 CEMIP2 SLC12A2 SACS EIF5B PDZD8 TYW1	2.55e-05	1487	101	15	33957083
Pubmed	Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes.	PCDHA12 PCDHA8 PCDHA6 PCDHA1	2.70e-05	59	101	4	23754746
Pubmed	MPP3 is required for maintenance of the apical junctional complex, neuronal migration, and stratification in the developing cortex.	MPDZ PALS1 PATJ	3.52e-05	22	101	3	23658188
Pubmed	The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin.	MPDZ PALS1 PATJ	3.52e-05	22	101	3	27521426
Pubmed	PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.	CASP8 GSDMC	4.99e-05	4	101	2	32929201
Pubmed	Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure.	MPDZ PALS1	4.99e-05	4	101	2	15316081
Pubmed	Regulation of the phosphatidylinositol 3-kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways by thyroid-stimulating hormone (TSH) and stimulating type TSH receptor antibodies in the thyroid gland.	RPS6KB1 TSHR	4.99e-05	4	101	2	12668683
Pubmed	Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis.	TYW1B TYW1	4.99e-05	4	101	2	17150819
Pubmed	Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules.	TCN2 CASQ2 VCAN PCSK9	5.01e-05	69	101	4	21491542
Pubmed	The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.	MPDZ PALS1 PATJ	5.22e-05	25	101	3	21145499
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	MAGED1 MPDZ SNAP47 CEMIP2 SLC12A2 ARNT2 PDZD8 TYW1 PATJ HECTD1	5.57e-05	733	101	10	34672954
Pubmed	Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway.	MPDZ PALS1 PATJ	5.89e-05	26	101	3	28720576
Pubmed	Same but different - Molecular comparison of human KTI12 and PSTK.	TDRKH MAGED1 MPDZ	6.61e-05	27	101	3	33417976
Pubmed	Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene.	MPDZ PALS1 PATJ	6.61e-05	27	101	3	23001562
Pubmed	CRB2 completes a fully expressed Crumbs complex in the Retinal Pigment Epithelium.	PALS1 PATJ	8.30e-05	5	101	2	26404741
Pubmed	A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions.	PALS1 PATJ	8.30e-05	5	101	2	21481793
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	FRAS1 MAGED1 RPS6KB1 MPDZ CEMIP2 PALS1 ABCE1 PATJ PCDHGC3	1.19e-04	650	101	9	38777146
Pubmed	NEDD4 controls the expression of GUCD1, a protein upregulated in proliferating liver cells.	PCDHA8 PCDHA6	1.24e-04	6	101	2	24743017
Pubmed	Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties.	MPDZ PATJ	1.24e-04	6	101	2	17397395
Pubmed	A genome-wide association study identifies susceptibility loci for Wilms tumor.	TCN2 PCSK9	1.24e-04	6	101	2	22544364
Pubmed	A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins.	PALS1 PATJ	1.24e-04	6	101	2	15863617
Pubmed	Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex.	MPDZ PALS1	1.24e-04	6	101	2	19506035
Pubmed	Juxtaposition of CNR protocadherins and reelin expression in the developing spinal cord.	PCDHA8 PCDHA6	1.24e-04	6	101	2	11312598
Pubmed	Quantifying domain-ligand affinities and specificities by high-throughput holdup assay.	MPDZ PALS1 PATJ	1.58e-04	36	101	3	26053890
Pubmed	Genome-wide screening and identification of novel proteolytic cleavage targets of caspase-8 and -10 in vitro.	CASP8 DOP1A	1.74e-04	7	101	2	18288386
Pubmed	MAGED1 is a novel regulator of a select subset of bHLH PAS transcription factors.	MAGED1 ARNT2	1.74e-04	7	101	2	27472814
Pubmed	Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif.	MPDZ PALS1 PATJ	2.17e-04	40	101	3	30865227
Pubmed	Common variants in the trichohyalin gene are associated with straight hair in Europeans.	FRAS1 TSHR	2.31e-04	8	101	2	19896111
Pubmed	AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation.	PALS1 PATJ	2.31e-04	8	101	2	34404733
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	SETD1A PCDHA9 ARNT2 CABIN1	2.47e-04	104	101	4	9205841
Pubmed	Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.	ADGRV1 LOXHD1 SLC12A2	2.89e-04	44	101	3	27534441
Pubmed	FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women.	CASP8 TLR6	2.97e-04	9	101	2	20554749
Pubmed	Molecular mechanisms governing Pcdh-gamma gene expression: evidence for a multiple promoter and cis-alternative splicing model.	PCDHA5 PCDHA4	2.97e-04	9	101	2	12154121
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	CUL4A ACLY CASP8 CARD10 TLR6 PRKAG3	3.13e-04	313	101	6	20800603
Pubmed	Genetics of rheumatoid arthritis contributes to biology and drug discovery.	CASP8 TXNDC11 PLCL2 CLNK	3.27e-04	112	101	4	24390342
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TET2 MAGED1 RAPGEF4 ZNF214 TRIM52 TXNDC11 SACS ZNF655 CEP70 PDZD8 CABIN1 HECTD1	3.54e-04	1285	101	12	35914814
Pubmed	mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.	RPS6KB1 EIF3H	3.70e-04	10	101	2	16286006
Pubmed	Genetic variants near PDGFRA are associated with corneal curvature in Australians.	SLC8A3 EIF3H	3.70e-04	10	101	2	22969067
Pubmed	A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function.	ADGRV1 LOXHD1	3.70e-04	10	101	2	17329413
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	CUL4A MAGED1 IPO8 NAP1L4 HEATR1 SNAP47 VPS13D MAGED4	3.96e-04	606	101	8	36538041
Pubmed	Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA.	IPO8 ABCE1 EIF3H	3.97e-04	49	101	3	24248602
Pubmed	Toward simpler and faster genome-wide mutagenesis in mice.	PCDHAC1 PCDHA1	4.51e-04	11	101	2	17572674
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	MRPL13 EXT2 SNAP47 CEMIP2 PALS1 SLC12A2 ABCE1 PDZD8 TYW1 FLRT3	4.58e-04	952	101	10	38569033
Pubmed	WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation.	CUL4A TLR6 HECTD1	4.74e-04	52	101	3	30655611
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	CUL4A MAGED1 IPO8 ACLY NAP1L4 MRPL13 MPDZ PALS1 EIF5B EIF3H HECTD1 HSP90AA4P	4.98e-04	1335	101	12	29229926
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	TET2 VPS13D PLCL2 HECTD1	5.75e-04	130	101	4	12421765
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	FRAS1 ANPEP ACLY EXT2 TXNDC11 CEMIP2 SLC12A2 ABCE1 TYW1 HECTD1 PCSK9	7.41e-04	1201	101	11	35696571
Pubmed	Expression patterns of NKCC1 in neurons and non-neuronal cells during cortico-hippocampal development.	ANPEP SLC12A2	7.43e-04	14	101	2	36573432
Pubmed	Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation.	PCDHA13 PCDHA4	7.43e-04	14	101	2	14672974
Pubmed	Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves.	MPDZ PALS1	8.55e-04	15	101	2	20237282
Pubmed	Maturation of postnatally generated olfactory bulb granule cells depends on functional γ-protocadherin expression.	PCDHGA6 PCDHGC3	8.55e-04	15	101	2	23515096
Pubmed	Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.	RAPGEF4 ARNT2 HSD17B2	9.11e-04	65	101	3	19598235
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	ACLY NAP1L4 HEATR1 SH2D4A EIF5B	9.26e-04	256	101	5	33397691
Pubmed	The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1+ hematoendothelial progenitors.	CEMIP2 VCAN	9.76e-04	16	101	2	33454424
Pubmed	MALS-3 regulates polarity and early neurogenesis in the developing cerebral cortex.	PALS1 PATJ	1.10e-03	17	101	2	18403412
Pubmed	KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR).	CUL4A SETD1A	1.10e-03	17	101	2	22902626
Interaction	PCDHA10 interactions	PCDHA9 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	1.72e-20	22	100	11	int:PCDHA10
Interaction	PCDHA8 interactions	PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 PCDHA2 PCDHA1	6.65e-12	55	100	9	int:PCDHA8
Interaction	PCDHA7 interactions	PCDHA9 PCDHA12 PCDHA8 PCDHA7 PCDHA4 PCDHA2	3.73e-11	14	100	6	int:PCDHA7
Interaction	PCDHA3 interactions	PCDHA9 PCDHA8 PCDHA6 PCDHA3 PCDHA1 TYW1	1.54e-08	34	100	6	int:PCDHA3
Interaction	PCDHA4 interactions	PCDHA9 PCDHA12 PCDHA8 PCDHA7 PCDHA4 PCDHA1 PCDHGC3	1.86e-08	60	100	7	int:PCDHA4
Interaction	PCDHGA10 interactions	PCDHA9 PCDHAC1 PCDHA12 PCDHA8 PCDHA4	2.99e-08	19	100	5	int:PCDHGA10
Interaction	PCDHA11 interactions	PCDHA9 PCDHA12 PCDHA4 PCDHA3 PCDHA1	2.99e-08	19	100	5	int:PCDHA11
Interaction	FLT3 interactions	PCDHA9 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1	5.89e-08	318	100	12	int:FLT3
Interaction	PCDHA1 interactions	PCDHA8 PCDHA4 PCDHA3 PCDHA1	7.05e-08	9	100	4	int:PCDHA1
Interaction	PCDHA9 interactions	PCDHA9 PCDHGA6 PCDHA7 PCDHA4 PCDHA3	4.92e-07	32	100	5	int:PCDHA9
Interaction	C2CD4B interactions	FRAS1 MPDZ ADGRV1 PALS1 PATJ	2.53e-06	44	100	5	int:C2CD4B
Interaction	PCDHAC2 interactions	PCDHA9 PCDHA8 PALS1 PDZD8 PATJ	2.84e-06	45	100	5	int:PCDHAC2
Interaction	PCDHA6 interactions	PCDHA8 PCDHA6 PCDHA3	9.74e-06	9	100	3	int:PCDHA6
Interaction	LONP2 interactions	PCDHA9 PCDHA12 PCDHA8 PCDHA4 PCDHA3	1.41e-05	62	100	5	int:LONP2
Interaction	PCDHA2 interactions	PCDHA8 PCDHA7 PCDHA2	4.15e-05	14	100	3	int:PCDHA2
Interaction	XAGE1A interactions	FRAS1 ADGRV1 CABIN1 PCDHGC3	5.02e-05	41	100	4	int:XAGE1A
Interaction	PCDHGB2 interactions	PCDHA9 PCDHGA6 PDZD8 PCDHGC3	6.65e-05	44	100	4	int:PCDHGB2
Interaction	PCDHA12 interactions	PCDHA12 PCDHA8 PCDHA7 PCDHA4	7.94e-05	46	100	4	int:PCDHA12
Interaction	FAM124A interactions	MPDZ PALS1 CEP70 PATJ	7.94e-05	46	100	4	int:FAM124A
Interaction	PCDHAC1 interactions	PCDHAC1 PDZD8 TYW1	1.08e-04	19	100	3	int:PCDHAC1
Interaction	CEP57L1 interactions	SNAP47 ZNF655 ARNT2 CEP70 PATJ	1.11e-04	95	100	5	int:CEP57L1
Cytoband	5q31	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	7.22e-21	115	101	14	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	5.37e-15	298	101	14	chr5q31
GeneFamily	Clustered protocadherins	PCDHA9 PCDHGA6 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PCDHGC3	2.18e-21	64	71	14	20
GeneFamily	PDZ domain containing\|Crumbs complex	MPDZ PALS1 PATJ	4.79e-06	9	71	3	1223
GeneFamily	PDZ domain containing	MPDZ PALS1 PDZD8 PATJ	3.01e-03	152	71	4	1220
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	CARD10 PALS1	4.65e-03	26	71	2	904
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	SH2D4A SLC12A2 SACS HYDIN	5.60e-03	181	71	4	694
Coexpression	MIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED	PCDHA9 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1	4.01e-10	261	101	12	MM1277
Coexpression	MIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED	PCDHA9 PCDHAC1 PCDHA13 PCDHA12 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1	2.13e-09	238	101	11	M2020
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-D\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PCDHA9 PCDHA12 PCDHA4 PCDHA2 MAGED4 PCDHGC3	4.10e-06	187	100	6	6c43669e19b5b54d72d1f5d876184fee53c05f0b
ToppCell	COVID-19_Mild-Classical_Monocyte-cMono_3\|COVID-19_Mild / Disease condition and Cell class	ANPEP TDRD9 EMB JAML CEMIP2 VCAN	5.37e-06	196	100	6	f245e929a286cb097130572e1027b4f01be8b04d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LOXHD1 GALNT17 SH2D4A ZNF655 CLNK	1.97e-05	146	100	5	e887e9de895fd453faa703997ef372cc6410fc49
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	EMB CASP8 TRIM52 CEMIP2 PATJ	2.32e-05	151	100	5	999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Lgi2_(Golgi_interneuron)--\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PCDHAC1 TSHR PFKFB1 PCSK9	2.74e-05	77	100	4	afe990041849a68fd75e0c11b633a7b90fefade1
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Lgi2_(Golgi_interneuron)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PCDHAC1 TSHR PFKFB1 PCSK9	2.74e-05	77	100	4	ec8f625cae561986ed27dfaefa8f822dd1c4fba1
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Lgi2_(Golgi_interneuron)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PCDHAC1 TSHR PFKFB1 PCSK9	2.74e-05	77	100	4	af7e1e76db33b115238b6fc61fc0dd86aab8e49d
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast-FB-1\|E18.5-samps / Age Group, Lineage, Cell class and subclass	PCDHA8 PCDHA7 PCDHA3 PCDHA1 VCAN	2.97e-05	159	100	5	b4bc888e978b1b577721b891b0af6ba9a1607044
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ANPEP TDRD9 PRKAG3 LOXHD1 VCAN	2.97e-05	159	100	5	fb9a45c1d596226128ce4f1adaebb066766e590a
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma\|TCGA-Brain / Sample_Type by Project: Shred V9	TDRKH TMEM63C SLC8A3 PLCL2 PDZD8	3.16e-05	161	100	5	5f6b2d7f80a8ee16651e304481d2da3fae313824
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHA9 PCDHA12 GALNT17 PLCL2 PCSK9	3.55e-05	165	100	5	1b7dfa173e83aa8c46a3153a3261866c065c3b73
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHA9 PCDHA12 GALNT17 PLCL2 PCSK9	3.55e-05	165	100	5	b4f7d33af7d053ec07b01bd67d861600a9c4822e
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DOCK9 CASP8 CEMIP2 SACS PATJ	3.76e-05	167	100	5	83969c36ac44b96afc9aa09400a99fa2b487f7ff
ToppCell	P15-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FRAS1 PFKFB1 HEATR1 PRKAG3 SH2D4A	3.76e-05	167	100	5	5c3d0763f73628c71c71f9883556bb4f1639f3cc
ToppCell	Striatum-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Striatum / BrainAtlas - Mouse McCarroll V32	PCDHAC1 PCDHA7 PCDHA3 TSHR	3.87e-05	84	100	4	9417fffe0ba79f5851920258dcd0f6c09218be13
ToppCell	droplet-Marrow-nan-18m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TDRKH EXT2 SH2D4A SLC12A2 MCM9	4.57e-05	174	100	5	55cc8300489d11322724159ec7d0e1d32a702e91
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FRAS1 PCDHA12 PCDHA8 ADGRV1 ARNT2	4.96e-05	177	100	5	d05497d2c80a66ec6a4e1733fea3a5534877a6a7
ToppCell	COPD-Lymphoid-T_Regulatory\|World / Disease state, Lineage and Cell class	EMB NAP1L4 CASP8 CEMIP2 CLNK	5.37e-05	180	100	5	51a12fbad5fa7bb12e6d616a02ff9b5141e2b063
ToppCell	LV-17._Lymphocyte\|LV / Chamber and Cluster_Paper	EMB CASP8 JAML CEMIP2 SLC8A3	5.51e-05	181	100	5	81fafa69c8c240250a667a5f3b321e8be1b9a288
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FRAS1 PRKAG3 PALS1 FLRT3 PATJ	5.66e-05	182	100	5	573771130247e869e4e58f22d4a1cb31989635cf
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FRAS1 PRKAG3 PALS1 FLRT3 PATJ	5.66e-05	182	100	5	6cfaa2b3b3974c13b01c943f4adb70768dcc35e4
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MAGED1 DOCK9 SNTN CEMIP2 HYDIN	5.80e-05	183	100	5	6f8f997ffc9eaebca2683de125b6069d07c07d26
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Hematopoietic-T_cells\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMEM63C TLR6 JAML PLCL2 CLNK	5.80e-05	183	100	5	f079179f2984def91ddf0b33d7949d5ecdbd380d
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Hematopoietic-T_cells-ILCP\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMEM63C TLR6 JAML PLCL2 CLNK	5.80e-05	183	100	5	49e8ee16e4f677f9f649e2a2faf1b9b16c5a27e7
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-Aerocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TDRKH DOCK9 RAPGEF4 CARD10 SLC12A2	6.11e-05	185	100	5	7b3d30a54bec66ca6b0209c86448f4fff97ed75c
ToppCell	Adult-Epithelial-club_cell-D231\|Adult / Lineage, Cell type, age group and donor	FRAS1 ADGRV1 TMEM130 HSD17B2 PATJ	6.43e-05	187	100	5	ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-immature_innate_lymphoid_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TDRKH EMB JAML ARNT2 ABHD8	6.43e-05	187	100	5	fae08f34dc4b15352bd4d10bc6c924fe119b5d5e
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-immature_innate_lymphoid_cell-Ly6g5b+_T\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TDRKH EMB JAML ARNT2 ABHD8	6.43e-05	187	100	5	e6b140b9fb582abf07aa6ea9bc437de3ba0d6de1
ToppCell	COVID-19-kidney-CD-IC-B\|kidney / Disease (COVID-19 only), tissue and cell type	GALNT17 SH2D4A SACS PLCL2 CLNK	6.43e-05	187	100	5	ce05b89860573fe0356102e2998d1ef6d1968034
ToppCell	P28-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	EMB PRKAG3 PALS1 SH2D4A FLRT3	6.43e-05	187	100	5	a4b41904ba05eb76212c949fc3ac197f906c8351
ToppCell	Adult-Epithelial-club_cell\|Adult / Lineage, Cell type, age group and donor	FRAS1 ADGRV1 TMEM130 HSD17B2 PATJ	6.93e-05	190	100	5	756bff697d30aec56c0ebfca94295f084a15bf37
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PCDHA8 PCDHA6 TMEM130 VCAN PCDHGC3	6.93e-05	190	100	5	6c7e1086c0a274cd5527c3104106e372811c9905
ToppCell	COVID-19-Heart-EC_3\|Heart / Disease (COVID-19 only), tissue and cell type	TCN2 DOCK9 MGAT4A RAPGEF4 CEMIP2	6.93e-05	190	100	5	78e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TET2 ANPEP JAML LOXHD1 VCAN	7.11e-05	191	100	5	63d4226a8b59f648bdc9f41e4b2d750dfa342034
ToppCell	COPD-Epithelial\|COPD / Disease state, Lineage and Cell class	MPDZ ADGRV1 SNTN PATJ HYDIN	7.28e-05	192	100	5	0644fad5df18f0021f6f49cca996d8cf47f972ff
ToppCell	Control-Lymphoid-T\|Control / Disease state, Lineage and Cell class	EMB MGAT4A NAP1L4 CASP8 CEMIP2	7.46e-05	193	100	5	af928046ccd1ca874be1534aef6ca7f27d90bc46
ToppCell	nucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-CD4_T\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	EMB MGAT4A NAP1L4 CASP8 CEMIP2	7.46e-05	193	100	5	9c9434a3297b85774b4f0ecab6294f44d738e29f
ToppCell	Control-Lymphoid-T\|Lymphoid / Disease state, Lineage and Cell class	EMB DOCK9 MGAT4A CASP8 JAML	7.83e-05	195	100	5	6687e579582d7a239bee80846de0cf827a6f6a62
ToppCell	COPD-Lymphoid-T\|COPD / Disease state, Lineage and Cell class	EMB MGAT4A NAP1L4 CASP8 CEMIP2	8.03e-05	196	100	5	30e53b8050d2a041f855d0e39bbd8f923c64c489
ToppCell	PCW_10-12-Endothelial-Endothelial_immature-endo_immature_venous_(4)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	TCN2 DOCK9 MGAT4A RAPGEF4 CARD10	8.03e-05	196	100	5	81278e696d823744267d6315c4d42799c4ea0b2c
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK9 TMEM130 VCAN ARNT2 PCDHGC3	8.62e-05	199	100	5	333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK9 TMEM130 VCAN ARNT2 HYDIN	8.62e-05	199	100	5	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK9 TMEM130 VCAN ARNT2 PCDHGC3	8.62e-05	199	100	5	e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_TRM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	EMB MGAT4A CASP8 JAML PLCL2	8.83e-05	200	100	5	be9a43acc2f926b9433ab3f018b911b03896a924
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FRAS1 ADGRV1 SH2D4A FLRT3 PATJ	8.83e-05	200	100	5	8683445ad5b70748c4a1f12eb77d47623085147e
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	EMB MGAT4A CASP8 JAML PLCL2	8.83e-05	200	100	5	c6c2b39359c65c9444987d02d1c899dff2ad1366
ToppCell	severe-CD163+_Monocytes_(Sample_ID1_d7)\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ANPEP TDRD9 TCN2 TP53I3 VCAN	8.83e-05	200	100	5	a3f22826f3d8f917ff0594bdadd93b60763bcaa2
ToppCell	Striatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Inhibitory_Neuron.Gad1Gad2.Pnoc_(Fast-spiking_interneuron,_Pvalb+/Pnoc+)-\|Striatum / BrainAtlas - Mouse McCarroll V32	PCDHA9 PCDHAC1 PCDHA7 PCDHA3	1.11e-04	110	100	4	5496c92932195386025254b9129d69b12c8e3340
ToppCell	Striatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Inhibitory_Neuron.Gad1Gad2.Pnoc_(Fast-spiking_interneuron,_Pvalb+/Pnoc+)--\|Striatum / BrainAtlas - Mouse McCarroll V32	PCDHA9 PCDHAC1 PCDHA7 PCDHA3	1.11e-04	110	100	4	41306a2d4a5a39569437eb123e47f98ef8afab24
ToppCell	Striatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Inhibitory_Neuron.Gad1Gad2.Pnoc_(Fast-spiking_interneuron,_Pvalb+/Pnoc+)\|Striatum / BrainAtlas - Mouse McCarroll V32	PCDHA9 PCDHAC1 PCDHA7 PCDHA3	1.11e-04	110	100	4	1fe08060248b25329f73b80d74435c108bee1359
ToppCell	Striatum-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Excitatory_Neuron.Slc17a7.Dkk3_(Deep_layer_cortex)-\|Striatum / BrainAtlas - Mouse McCarroll V32	C1QL3 DNAH2 PCDHA5 SERPINB8	1.27e-04	114	100	4	3352ce794a646e3e7f15a991dd8a847a3c705394
ToppCell	Striatum-Neuronal-Excitatory-eN1(Slc17a7)\|Striatum / BrainAtlas - Mouse McCarroll V32	C1QL3 DNAH2 PCDHA5 SERPINB8	1.27e-04	114	100	4	158dc333b337d5e83183b2f010a8e030c7a57bc7
ToppCell	Striatum-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Excitatory_Neuron.Slc17a7.Dkk3_(Deep_layer_cortex)\|Striatum / BrainAtlas - Mouse McCarroll V32	C1QL3 DNAH2 PCDHA5 SERPINB8	1.27e-04	114	100	4	238f2541e0514df8d24d767f833980d770b920a4
ToppCell	Striatum-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1\|Striatum / BrainAtlas - Mouse McCarroll V32	C1QL3 DNAH2 PCDHA5 SERPINB8	1.27e-04	114	100	4	e63c0ebf843392c2926732bb8792eb6ee69bec15
Drug	Azacitidine	PCDHA9 PCDHA12 CASP8 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 TSHR	3.17e-07	415	101	12	ctd:D001374
Disease	1,5 anhydroglucitol measurement	PCDHA9 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1	5.73e-23	29	100	12	EFO_0008009
Disease	visceral adipose tissue measurement, body mass index	PCDHA9 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1	1.67e-16	87	100	12	EFO_0004340, EFO_0004765
Disease	neutrophil count, basophil count	TET2 PCDHA9 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 JAML	7.79e-13	224	100	13	EFO_0004833, EFO_0005090
Disease	neuroticism measurement, cognitive function measurement	TET2 PCDHA9 EMB PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 SNTN ZNF655 PLCL2	8.30e-11	566	100	16	EFO_0007660, EFO_0008354
Disease	post-traumatic stress disorder symptom measurement	PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1	3.79e-10	82	100	8	EFO_0008535
Disease	Abnormality of refraction	PCDHA9 TDRD9 EMB PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1	6.55e-08	673	100	14	HP_0000539
Disease	neutrophil count	CUL4A TET2 PCDHA9 EMB NAP1L4 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 TSHR JAML GALNT17 HYDIN	1.73e-07	1382	100	19	EFO_0004833
Disease	post-traumatic stress disorder	PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1	4.56e-07	202	100	8	EFO_0001358
Disease	pulse pressure measurement	TET2 PCDHA9 RPS6KB1 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 CASQ2 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 GSDMC SLC12A2 HYDIN	9.28e-07	1392	100	18	EFO_0005763
Disease	vital capacity	TET2 PCDHA9 IPO8 PCDHAC1 PCDHA13 PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 EIF3H PATJ	3.99e-06	1236	100	16	EFO_0004312
Disease	ACUTE ALCOHOL WITHDRAWAL	ANPEP MPDZ	1.14e-05	2	100	2	C0149821
Disease	Hypoplastic Left Heart Syndrome	PCDHA9 PCDHA13	1.13e-04	5	100	2	C0152101
Disease	Moyamoya disease	TCN2 DOCK9 RAPGEF4	3.41e-04	40	100	3	MONDO_0016820
Disease	primary immunodeficiency disease (is_implicated_in)	TET2 CASP8 CARD10	3.94e-04	42	100	3	DOID:612 (is_implicated_in)
Disease	Nephroblastoma	TCN2 PCSK9	5.03e-04	10	100	2	Orphanet_654
Disease	depressive symptom measurement	PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 PLCL2	6.29e-04	426	100	7	EFO_0007006
Disease	N-acetyltaurine measurement	C1QL3 PCDHA4	8.66e-04	13	100	2	EFO_0020023
Disease	hyperinsulinism (biomarker_via_orthology)	RPS6KB1 PFKFB1	1.16e-03	15	100	2	DOID:2018 (biomarker_via_orthology)
Disease	cholesterol to total lipids in medium VLDL percentage	ANKRD31 PRKAG3 PCSK9	1.29e-03	63	100	3	EFO_0022239
Disease	triglycerides:total lipids ratio, low density lipoprotein cholesterol measurement	ANKRD31 PRKAG3 TYW1B PCSK9	1.72e-03	150	100	4	EFO_0004611, EFO_0020947
Disease	p-tau measurement	TMEM63C GALNT17 PATJ	1.90e-03	72	100	3	EFO_0004763
Disease	dilated cardiomyopathy (biomarker_via_orthology)	RPS6KB1 CASP8	2.51e-03	22	100	2	DOID:12930 (biomarker_via_orthology)
Disease	Colorectal Neoplasms	TET2 TCN2 CASP8 ABCE1 EIF3H	2.56e-03	277	100	5	C0009404
Disease	unipolar depression	TDRD9 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA1 GALNT17 FIG4 VCAN MCM9	2.59e-03	1206	100	11	EFO_0003761
Disease	rheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement	CASP8 TXNDC11 PLCL2 CLNK	2.71e-03	170	100	4	EFO_0000685, EFO_0007791, EFO_0007837

Protein segments in the cluster

Peptide	Gene	Start	Entry
PLDEELDSHLSYIKI	PFKFB1	206	P16118
ELVQNEIYPIVIHVE	CARD10	931	Q9BWT7
EIYPIVIHVEVTEKN	CARD10	936	Q9BWT7
QHAIEESVVLIYDPI	EIF3H	141	O15372
TIIDIDHTKPVYEDI	VCAN	2576	P13611
SPLVQIYEIEQHKIE	PRKAG3	256	Q9UGI9
LIEPVKYSDEGEHLV	ADAM7	141	Q9H2U9
SVVLHLEPGDEVYIK	C1QL3	216	Q5VWW1
KYEQVHILPVGRIEE	GSDMC	296	Q9BYG8
KIPYLEELHLDDNSV	FLRT3	126	Q9NZU0
VHLLDDNIPEEKEVY	ADGRV1	2771	Q8WXG9
TIILTIYPHEEIEVE	ADGRV1	4591	Q8WXG9
ETYIEIQTEHLPQLL	DOP1A	496	Q5JWR5
DKTELVEPTEYLVVH	ANPEP	151	P15144
DEVYHAELTVPVLLV	ABHD8	351	Q96I13
STLYEQVHPDDVEKL	ARNT2	181	Q9HBZ2
KVYALQPLDHEELEL	PCDHA9	516	Q9Y5H5
LDRIYPVTEIQEAHK	TP53I3	301	Q53FA7
KVYALQPLDHEEVEL	PCDHA2	516	Q9Y5H9
KVYALQPLDHEELEL	PCDHA6	516	Q9UN73
SSIDPLDIEDVYQHK	ANKRD31	621	Q8N7Z5
KVYALQPLDHEELEL	PCDHA7	516	Q9UN72
LHSLIDNLYPEEKLD	MGAT4A	156	Q9UM21
LVQEYDEPILKHLQD	NAP1L4	176	Q99733
EDKLNLYPVEVEIVD	PCDHGA6	111	Q9Y5G7
KVYALQPLDHEELEL	PCDHA8	516	Q9Y5H6
KVYALQPLDHEELEL	PCDHA3	516	Q9Y5H8
EDILEEYPLNTKVEV	FRAS1	3936	Q86XX4
IDKEEHLYILISTPE	MAGED1	531	Q9Y5V3
KDVIREYDEHFPEII	MAGED4	441	Q96JG8
AVHTEPLDELYEVLV	FAM86C1P	56	Q9NVL1
ELYPSEVVEIQKLVH	LOXHD1	801	Q8IVV2
EVVEIQKLVHYEVEI	LOXHD1	806	Q8IVV2
YVPKDIEDPELIIKH	TMEM63C	226	Q9P1W3
LELALKLPHVDYIEE	PCSK9	131	Q8NBP7
HLVEEVSVLPKEEQF	PDZD8	816	Q8NEN9
ILEEVKHPFIVDLIY	RPS6KB1	146	P23443
VQGIPRVHELKIEEY	METTL25B	361	Q96FB5
LNKASTVIHYEIPEE	PCDHGC3	26	Q9UN70
VYALQPLDHEEVELL	PCDHA5	516	Q9Y5H7
KVYALQPLDHEELEL	PCDHA1	516	Q9Y5I3
KVYALQPLDHEELEL	PCDHA13	516	Q9Y5I0
VLESPHYAVKILEIE	PALS1	111	Q8N3R9
TYDLVLEDPLELHKI	PCDHAC1	96	Q9H158
KVYALQPLDHEELEL	PCDHA4	516	Q9UN74
SLINPDRYIIVVEHD	ABCE1	261	P61221
IEHVEQYLGTDELPK	HECTD1	1896	Q9ULT8
EILAIKYVEHPQIDS	HYDIN	1141	Q4G0P3
DTHPYKEELETALEQ	CABIN1	931	Q9Y6J0
YDEIKIELPTQLHEK	DOCK9	711	Q9BZ29
PEDLQSIIYKLEEHE	CEP70	546	Q8NHQ1
PKDLVIIDDRHVYTQ	FIG4	46	Q92562
VPEYLNHVSKRLEEE	CUL4A	256	Q13619
EEELKVPLEEYVHKR	GALNT17	196	Q6IS24
SKIEEYEPVHSLEEL	CEMIP2	1096	Q9UHN6
IKPHDDCTVEQIYEI	CASP8	281	Q14790
PYTEEELVEFVKEHQ	CASQ2	231	O14958
YPRTLDVVLEEHLKE	HEATR1	436	Q9H583
SEEHIELVVLSYLVP	EMB	246	Q6PCB8
KHGLEVIYTIEPIDE	HSP90AA4P	221	Q58FG1
KDILDHLPAEVQEDY	HSD17B2	281	P37059
HEQFAILEKYEVPVE	DNAH2	1096	Q9P225
IPKDDELSEEQISHY	OLAH	141	Q9NV23
LKPEEVVINLEYESD	SACS	3806	Q9NZJ4
CIPEYEEKDHEVALI	DTWD1	126	Q8N5C7
EIFHPEIQKDLLVLE	GARNL3	181	Q5VVW2
KVYALQPLDHEELEL	PCDHA12	516	Q9UN75
DLVLQKHVIEFYEEI	IPO8	641	O15397
VVEHDVLLRTKYTPE	MUC17	4246	Q685J3
LLILKERDEDAHYPV	MCM9	26	Q9NXL9
VDDLEIIYEELLHIK	RAPGEF4	341	Q8WZA2
DDIKVHSPYEISIRQ	SNAP47	301	Q5SQN1
HLLEEPVITKDIYEV	TDRD9	341	Q8NDG6
KHIYSPIIVREVIEE	JAML	336	Q86YT9
YKEDEIPVLKDELIH	EIF5B	951	O60841
INEEISLEIIHKYEP	PLCL2	376	Q9UPR0
PKYREILSELDEHTE	SNTN	101	A6NMZ2
KYGEVEEVEILLHPR	SETD1A	116	O15047
VHTQVLELPYVEEEL	SERPINB8	211	P50452
VHDSVVDKLLYAVEP	TCN2	171	P20062
EHTIRYVLPDGKEIQ	ACTL7A	296	Q9Y615
IRDYQGPLKEHEVTI	ACLY	361	P53396
EDIIEHYKNFPIILI	CLNK	386	Q7Z7G1
KQHSVLPLEEVVQEY	TRIM52	256	Q96A61
LVHKGYAIELPEDIE	TDRKH	486	Q9Y2W6
ITYVPAEHLEEFKIS	MPDZ	1086	O75970
LIKETYQLHRDDPEV	STKLD1	596	Q8NE28
DTPLNAIVIHEVYEE	PATJ	1456	Q8NI35
IIAFEEIIEPYRLHE	SLC12A2	1101	P55011
LHPEYREDLEALQVK	EXT2	261	Q93063
LADLVEYHKEEPITS	SH2D4A	416	Q9H788
EYIPEDILKNLVEEL	MRPL13	131	Q9BYD1
VPYLEKEDIQICLHE	TLR6	661	Q9Y2C9
HPLIDEITEVALEYN	TXNDC11	391	Q6PKC3
LKHDITQVPETREVY	ZNF655	76	Q8N720
LETPSEYLEIVRENH	TMEM130	406	Q8N3G9
INLKEYDPDDHLIEE	TYW1	111	Q9NV66
EDEQLHVLPLYKVSD	TET2	1411	Q6N021
QIISHYKEEPLTERI	PIGM	406	Q9H3S5
EQKLIVQHSYIPVEE	ZNF214	181	Q9UL59
NLKEYDPDDHLIEEV	TYW1B	66	Q6NUM6
EDVYELIENSHLTPK	TSHR	736	P16473
VHPYETKEFIINDIL	VPS13D	4036	Q5THJ4
GEHPKLEVIIEESYE	SLC8A3	661	P57103