Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	pre-mRNA 3'-splice site binding	ZRSR2P1 ZRSR2	1.23e-04	7	49	2	GO:0030628
GeneOntologyCellularComponent	U2AF complex	ZRSR2P1 ZRSR2	1.12e-04	7	49	2	GO:0089701
GeneOntologyCellularComponent	SCAR complex	CYFIP1 CYFIP2	3.50e-04	12	49	2	GO:0031209
GeneOntologyCellularComponent	proton-transporting V-type ATPase, V0 domain	ATP6V0A4 ATP6V0D2	3.50e-04	12	49	2	GO:0033179
Domain	Cytoplasmic_FMR1-int	CYFIP1 CYFIP2	7.02e-06	2	50	2	IPR008081
Domain	FragX_IP	CYFIP1 CYFIP2	7.02e-06	2	50	2	PF05994
Domain	DUF1394	CYFIP1 CYFIP2	4.20e-05	4	50	2	PF07159
Domain	DUF1394	CYFIP1 CYFIP2	4.20e-05	4	50	2	IPR009828
Domain	U2AF_small	ZRSR2P1 ZRSR2	6.99e-05	5	50	2	IPR009145
Domain	GDS_CDC24_CS	VAV3 MCF2L FARP2	1.54e-04	39	50	3	IPR001331
Domain	DH_1	VAV3 MCF2L FARP2	6.40e-04	63	50	3	PS00741
Domain	RhoGEF	VAV3 MCF2L FARP2	8.00e-04	68	50	3	SM00325
Domain	RhoGEF	VAV3 MCF2L FARP2	8.71e-04	70	50	3	PF00621
Domain	DH_2	VAV3 MCF2L FARP2	8.71e-04	70	50	3	PS50010
Domain	DH-domain	VAV3 MCF2L FARP2	9.08e-04	71	50	3	IPR000219
Domain	-	VAV3 MCF2L FARP2	9.08e-04	71	50	3	1.20.900.10
Domain	ZnF_C3H1	ZRSR2P1 ZRSR2	7.32e-03	48	50	2	SM00356
Domain	HEAT	CAND1 KPNB1	7.32e-03	48	50	2	PF02985
Domain	zf-CCCH	ZRSR2P1 ZRSR2	7.62e-03	49	50	2	PF00642
Domain	HEAT	CAND1 KPNB1	1.06e-02	58	50	2	IPR000357
Domain	Znf_CCCH	ZRSR2P1 ZRSR2	1.06e-02	58	50	2	IPR000571
Pathway	REACTOME_RAC1_GTPASE_CYCLE	CYFIP1 PIK3CA VAV3 MCF2L CYFIP2 FARP2	1.05e-05	175	41	6	MM15599
Pathway	REACTOME_INNATE_IMMUNE_SYSTEM	IFNB1 CYFIP1 CAND1 PIK3CA ATP6V0A4 VPS35L VAV3 ATP6V0D2 XRCC5 ITGB2 NOS3 CYFIP2 KPNB1	1.09e-05	1128	41	13	M1036
Pathway	REACTOME_SIGNALING_BY_VEGF	CYFIP1 PIK3CA VAV3 NOS3 CYFIP2	1.15e-05	103	41	5	MM14752
Pathway	REACTOME_SIGNALING_BY_VEGF	CYFIP1 PIK3CA VAV3 NOS3 CYFIP2	1.32e-05	106	41	5	M27077
Pathway	REACTOME_RAC1_GTPASE_CYCLE	CYFIP1 PIK3CA VAV3 MCF2L CYFIP2 FARP2	1.40e-05	184	41	6	M41809
Pathway	REACTOME_INNATE_IMMUNE_SYSTEM	CYFIP1 CAND1 PIK3CA ATP6V0A4 VPS35L VAV3 ATP6V0D2 XRCC5 ITGB2 NOS3 CYFIP2 KPNB1	1.66e-05	995	41	12	MM14661
Pathway	KEGG_MEDICUS_PATHOGEN_SHIGELLA_IPGD_TO_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY	CYFIP1 PIK3CA CYFIP2	7.92e-05	29	41	3	M47717
Pathway	PID_CDC42_REG_PATHWAY	VAV3 MCF2L FARP2	8.78e-05	30	41	3	M83
Pathway	KEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPB_TO_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY	CYFIP1 PIK3CA CYFIP2	8.78e-05	30	41	3	M47738
Pathway	REACTOME_ROS_AND_RNS_PRODUCTION_IN_PHAGOCYTES	ATP6V0A4 ATP6V0D2 NOS3	1.53e-04	36	41	3	M26923
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PI3K_TO_PI3K_SIGNALING_PATHWAY	PIK3CA RPS6KB1	1.72e-04	7	41	2	M47407
Pathway	WP_G13_SIGNALING	CYFIP1 PIK3CA RPS6KB1	1.79e-04	38	41	3	M39606
Pathway	REACTOME_ROS_AND_RNS_PRODUCTION_IN_PHAGOCYTES	ATP6V0A4 ATP6V0D2 NOS3	1.79e-04	38	41	3	MM14519
Pathway	REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES	CYFIP1 PIK3CA ATP6V0A4 VAV3 ATP6V0D2 NOS3 CYFIP2	1.80e-04	418	41	7	MM15587
Pathway	WP_MICROGLIA_PATHOGEN_PHAGOCYTOSIS_PATHWAY	PIK3CA VAV3 ITGB2	2.09e-04	40	41	3	M39695
Pathway	REACTOME_RHO_GTPASE_CYCLE	CYFIP1 WDR11 PIK3CA VAV3 MCF2L CYFIP2 FARP2	2.43e-04	439	41	7	MM15595
Pathway	WP_FIBRIN_COMPLEMENT_RECEPTOR_3_SIGNALING	IFNB1 PIK3CA ITGB2	2.60e-04	43	41	3	M39744
Pathway	REACTOME_RHO_GTPASE_CYCLE	CYFIP1 WDR11 PIK3CA VAV3 MCF2L CYFIP2 FARP2	2.83e-04	450	41	7	M27078
Pathway	WP_MICROGLIA_PATHOGEN_PHAGOCYTOSIS_PATHWAY	PIK3CA VAV3 ITGB2	3.18e-04	46	41	3	MM15837
Pathway	REACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS	CYFIP1 PIK3CA VAV3 CYFIP2	3.26e-04	114	41	4	MM14814
Pathway	WP_FIBRIN_COMPLEMENT_RECEPTOR_3_SIGNALING_PATHWAY	IFNB1 PIK3CA ITGB2	3.61e-04	48	41	3	MM15897
Pathway	KEGG_REGULATION_OF_ACTIN_CYTOSKELETON	CYFIP1 PIK3CA VAV3 ITGB2 CYFIP2	3.62e-04	213	41	5	M18306
Pathway	KEGG_MEDICUS_VARIANT_EGFR_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	PIK3CA RPS6KB1	3.66e-04	10	41	2	M47400
Pathway	PID_ANGIOPOIETIN_RECEPTOR_PATHWAY	PIK3CA RPS6KB1 NOS3	3.83e-04	49	41	3	M92
Pathway	KEGG_MEDICUS_REFERENCE_KITLG_KIT_PI3K_SIGNALING_PATHWAY	PIK3CA RPS6KB1	4.46e-04	11	41	2	M47403
Pathway	KEGG_MEDICUS_REFERENCE_IGF2_IGF1R_PI3K_SIGNALING_PATHWAY	PIK3CA RPS6KB1	4.46e-04	11	41	2	M47484
Pathway	KEGG_MEDICUS_REFERENCE_EREG_EGFR_PI3K_SIGNALING_PATHWAY	PIK3CA RPS6KB1	4.46e-04	11	41	2	M47499
Pathway	KEGG_MEDICUS_REFERENCE_AREG_EGFR_PI3K_SIGNALING_PATHWAY	PIK3CA RPS6KB1	4.46e-04	11	41	2	M47501
Pathway	KEGG_MEDICUS_VARIANT_ERBB2_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	PIK3CA RPS6KB1	5.35e-04	12	41	2	M47393
Pathway	REACTOME_IRON_UPTAKE_AND_TRANSPORT	CAND1 ATP6V0A4 ATP6V0D2	5.69e-04	56	41	3	MM15638
Pathway	PID_SHP2_PATHWAY	PIK3CA NOS3 IL6ST	5.99e-04	57	41	3	M100
Pathway	REACTOME_IRON_UPTAKE_AND_TRANSPORT	CAND1 ATP6V0A4 ATP6V0D2	6.31e-04	58	41	3	M962
Pathway	KEGG_MEDICUS_REFERENCE_PDGF_PDGFR_PI3K_SIGNALING_PATHWAY	PIK3CA RPS6KB1	6.31e-04	13	41	2	M47398
Pathway	KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	IFNB1 PIK3CA VAV3 ITGB2	6.54e-04	137	41	4	M5669
Pathway	REACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS	CYFIP1 PIK3CA VAV3 CYFIP2	7.68e-04	143	41	4	M27107
Pathway	REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES	CYFIP1 PIK3CA ATP6V0A4 VAV3 ATP6V0D2 NOS3 CYFIP2	7.72e-04	532	41	7	M27870
Pathway	KEGG_MEDICUS_REFERENCE_RELN_VLDLR_PI3K_SIGNALING_PATHWAY	PIK3CA RPS6KB1	8.46e-04	15	41	2	M47663
Pathway	BIOCARTA_GCR_PATHWAY	PIK3CA NOS3	1.09e-03	17	41	2	M10066
Pathway	BIOCARTA_GCR_PATHWAY	PIK3CA NOS3	1.09e-03	17	41	2	MM1372
Pathway	REACTOME_RHOG_GTPASE_CYCLE	CYFIP1 VAV3 MCF2L	1.14e-03	71	41	3	MM15604
Pathway	REACTOME_RHOG_GTPASE_CYCLE	CYFIP1 VAV3 MCF2L	1.28e-03	74	41	3	M41814
Pathway	PID_AVB3_INTEGRIN_PATHWAY	PIK3CA RPS6KB1 VAV3	1.28e-03	74	41	3	M160
Pathway	PID_EPHA2_FWD_PATHWAY	PIK3CA VAV3	1.37e-03	19	41	2	M273
Pathway	BIOCARTA_IGF1MTOR_PATHWAY	PIK3CA RPS6KB1	1.37e-03	19	41	2	M16991
Pathway	REACTOME_SIGNALING_BY_INSULIN_RECEPTOR	PIK3CA ATP6V0A4 ATP6V0D2	1.39e-03	76	41	3	MM15442
Pathway	BIOCARTA_MTOR_PATHWAY	PIK3CA RPS6KB1	1.52e-03	20	41	2	MM1437
Pathway	KEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPE_TO_RAC_SIGNALING_PATHWAY	CYFIP1 CYFIP2	1.52e-03	20	41	2	M47737
Pathway	BIOCARTA_IGF1MTOR_PATHWAY	PIK3CA RPS6KB1	1.52e-03	20	41	2	MM1496
Pathway	BIOCARTA_RAC1_PATHWAY	PIK3CA RPS6KB1	1.67e-03	21	41	2	M8601
Pathway	BIOCARTA_RAC1_PATHWAY	PIK3CA RPS6KB1	1.67e-03	21	41	2	MM1463
Pathway	REACTOME_SIGNALING_BY_INSULIN_RECEPTOR	PIK3CA ATP6V0A4 ATP6V0D2	1.72e-03	82	41	3	M1021
Pathway	WP_FOCAL_ADHESION_PI3KAKTMTORSIGNALING	IFNB1 PIK3CA RPS6KB1 ITGB2 NOS3	1.74e-03	302	41	5	M39719
Pathway	BIOCARTA_MTOR_PATHWAY	PIK3CA RPS6KB1	1.84e-03	22	41	2	M16563
Pathway	BIOCARTA_EIF4_PATHWAY	PIK3CA RPS6KB1	2.01e-03	23	41	2	MM1470
Pathway	BIOCARTA_HER2_PATHWAY	PIK3CA IL6ST	2.01e-03	23	41	2	MM1480
Pathway	BIOCARTA_HER2_PATHWAY	PIK3CA IL6ST	2.01e-03	23	41	2	M18719
Pathway	REACTOME_RAC2_GTPASE_CYCLE	CYFIP1 PIK3CA VAV3	2.04e-03	87	41	3	MM15600
Pathway	REACTOME_RAC2_GTPASE_CYCLE	CYFIP1 PIK3CA VAV3	2.11e-03	88	41	3	M41810
Pathway	WP_ANGIOGENESIS	PIK3CA NOS3	2.19e-03	24	41	2	M39556
Pathway	BIOCARTA_CTCF_PATHWAY	PIK3CA RPS6KB1	2.19e-03	24	41	2	M11420
Pathway	BIOCARTA_CTCF_PATHWAY	PIK3CA RPS6KB1	2.19e-03	24	41	2	MM1373
Pathway	BIOCARTA_EIF4_PATHWAY	PIK3CA RPS6KB1	2.19e-03	24	41	2	M4791
Pathway	KEGG_MEDICUS_REFERENCE_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY	CYFIP1 CYFIP2	2.37e-03	25	41	2	M47716
Pathway	REACTOME_NEUTROPHIL_DEGRANULATION	CYFIP1 CAND1 VPS35L XRCC5 ITGB2 KPNB1	2.42e-03	478	41	6	M27620
Pathway	WP_FOCAL_ADHESION_PI3KAKTMTOR_SIGNALING_PATHWAY	IFNB1 PIK3CA RPS6KB1 ITGB2 NOS3	2.43e-03	326	41	5	MM15917
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	CYFIP1 WDR11 PIK3CA VAV3 MCF2L CYFIP2 FARP2	2.43e-03	649	41	7	MM15690
Pathway	PID_VEGFR1_PATHWAY	PIK3CA NOS3	2.57e-03	26	41	2	M226
Pathway	KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS	PIK3CA RPS6KB1 VAV3	2.70e-03	96	41	3	M16121
Pathway	BIOCARTA_VEGF_PATHWAY	PIK3CA NOS3	2.77e-03	27	41	2	M12975
Pathway	REACTOME_VEGFR2_MEDIATED_VASCULAR_PERMEABILITY	VAV3 NOS3	2.77e-03	27	41	2	M27422
Pathway	REACTOME_DAP12_SIGNALING	PIK3CA VAV3	3.19e-03	29	41	2	M27171
Pathway	PID_IGF1_PATHWAY	PIK3CA RPS6KB1	3.19e-03	29	41	2	M125
Pathway	REACTOME_NEUTROPHIL_DEGRANULATION	CYFIP1 CAND1 VPS35L XRCC5 ITGB2 KPNB1	3.37e-03	511	41	6	MM15330
Pathway	WP_GLYCEROPHOSPHOLIPID_BIOSYNTHETIC_PATHWAY	PIK3CA GPAT4	3.41e-03	30	41	2	M39592
Pathway	PID_NECTIN_PATHWAY	PIK3CA FARP2	3.41e-03	30	41	2	M72
Pathway	REACTOME_VEGFR2_MEDIATED_VASCULAR_PERMEABILITY	VAV3 NOS3	3.41e-03	30	41	2	MM15170
Pathway	REACTOME_INSULIN_RECEPTOR_RECYCLING	ATP6V0A4 ATP6V0D2	3.41e-03	30	41	2	M506
Pathway	KEGG_MEDICUS_REFERENCE_FGF_FGFR_PI3K_SIGNALING_PATHWAY	PIK3CA RPS6KB1	3.64e-03	31	41	2	M47396
Pathway	REACTOME_DAP12_SIGNALING	PIK3CA VAV3	3.64e-03	31	41	2	MM14886
Pathway	PID_AVB3_OPN_PATHWAY	PIK3CA VAV3	3.64e-03	31	41	2	M63
Pathway	REACTOME_INSULIN_RECEPTOR_RECYCLING	ATP6V0A4 ATP6V0D2	3.64e-03	31	41	2	MM15467
Pathway	REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING	ATP6V0A4 ATP6V0D2	3.64e-03	31	41	2	MM15639
Pathway	REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING	ATP6V0A4 ATP6V0D2	3.64e-03	31	41	2	M991
Pubmed	Defining the membrane proteome of NK cells.	CAND1 WDR11 GLG1 DDX56 XRCC5 ITGB2 M6PR GPAT4 IL6ST CYFIP2 KPNB1	6.57e-07	1168	50	11	19946888
Pubmed	Different dysregulations of CYFIP1 and CYFIP2 in distinct types of dementia.	CYFIP1 CYFIP2	2.03e-06	2	50	2	38128786
Pubmed	ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells.	ZRSR2P1 ZRSR2	2.03e-06	2	50	2	33691379
Pubmed	C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response.	CYFIP1 CYFIP2	2.03e-06	2	50	2	24357318
Pubmed	Zrsr2 and functional U12-dependent spliceosome are necessary for follicular development.	ZRSR2P1 ZRSR2	2.03e-06	2	50	2	35198906
Pubmed	Cytoplasmic FMR1 interacting protein (CYFIP) family members and their function in neural development and disorders.	CYFIP1 CYFIP2	2.03e-06	2	50	2	34327661
Pubmed	Cytoplasmic FMRP interacting protein 1/2 (CYFIP1/2) expression analysis in autism.	CYFIP1 CYFIP2	2.03e-06	2	50	2	29752658
Pubmed	Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion.	CYFIP1 CYFIP2	2.03e-06	2	50	2	35567753
Pubmed	Cyfip1 Haploinsufficiency Increases Compulsive-Like Behavior and Modulates Palatable Food Intake in Mice: Dependence on Cyfip2 Genetic Background, Parent-of Origin, and Sex.	CYFIP1 CYFIP2	2.03e-06	2	50	2	31324746
Pubmed	NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons.	CYFIP1 PIK3CA CYFIP2	4.22e-06	22	50	3	21946561
Pubmed	Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1.	ZRSR2P1 ZRSR2	6.07e-06	3	50	2	8586425
Pubmed	Wound healing defect of Vav3-/- mice due to impaired {beta}2-integrin-dependent macrophage phagocytosis of apoptotic neutrophils.	VAV3 ITGB2	6.07e-06	3	50	2	19147786
Pubmed	Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic neoplasm in mice.	ZRSR2P1 ZRSR2	6.07e-06	3	50	2	36030305
Pubmed	Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases.	PIK3CA NOS3	6.07e-06	3	50	2	19505983
Pubmed	Vacuolar H+-ATPase d2 subunit: molecular characterization, developmental regulation, and localization to specialized proton pumps in kidney and bone.	ATP6V0A4 ATP6V0D2	6.07e-06	3	50	2	15800125
Pubmed	Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway.	PIK3CA RPS6KB1	6.07e-06	3	50	2	16839745
Pubmed	Glomerular endothelial PI3 kinase-α couples to VEGFR2, but is not required for eNOS activation.	PIK3CA NOS3	6.07e-06	3	50	2	21937609
Pubmed	Berberine protects endothelial progenitor cell from damage of TNF-α via the PI3K/AKT/eNOS signaling pathway.	PIK3CA NOS3	1.21e-05	4	50	2	25257463
Pubmed	Mouse U2af1-rs1 is a neomorphic imprinted gene.	ZRSR2P1 ZRSR2	1.21e-05	4	50	2	9001233
Pubmed	Interchangeable functions of Arabidopsis PIROGI and the human WAVE complex subunit SRA1 during leaf epidermal development.	CYFIP1 CYFIP2	1.21e-05	4	50	2	15294869
Pubmed	Mollugin induces tumor cell apoptosis and autophagy via the PI3K/AKT/mTOR/p70S6K and ERK signaling pathways.	PIK3CA RPS6KB1	1.21e-05	4	50	2	24887566
Pubmed	Retrolinkin recruits the WAVE1 protein complex to facilitate BDNF-induced TrkB endocytosis and dendrite outgrowth.	CYFIP1 CYFIP2	1.21e-05	4	50	2	27605705
Pubmed	Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.	CYFIP1 CYFIP2	1.21e-05	4	50	2	20228810
Pubmed	Cloning and mapping of the U2af1-rs2 gene with a high transmission distortion in interspecific backcross progeny.	ZRSR2P1 ZRSR2	1.21e-05	4	50	2	7558001
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	EPPK1 FASTKD1 PUS1 XRCC5 DHX29 KPNB1 APOBEC3F NCOA5	1.84e-05	807	50	8	22681889
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	CAND1 EPPK1 GLG1 RPS6KB1 ZNF749 XRCC5 CYFIP2 KPNB1	1.84e-05	807	50	8	30575818
Pubmed	Activation of the PI3K/Akt/mTOR/p70S6K pathway is involved in S100A4-induced viability and migration in colorectal cancer cells.	PIK3CA RPS6KB1	2.02e-05	5	50	2	24936148
Pubmed	MicroRNA-130a alleviates human coronary artery endothelial cell injury and inflammatory responses by targeting PTEN via activating PI3K/Akt/eNOS signaling pathway.	PIK3CA NOS3	2.02e-05	5	50	2	27713121
Pubmed	a4, a unique kidney-specific isoform of mouse vacuolar H+-ATPase subunit a.	ATP6V0A4 ATP6V0D2	2.02e-05	5	50	2	11498539
Pubmed	A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.	CYFIP1 CYFIP2	3.03e-05	6	50	2	11438699
Pubmed	Sequestration of Gβγ by deubiquitinated arrestins into the nucleus as a novel desensitization mechanism of G protein-coupled receptors.	ARR3 KPNB1	3.03e-05	6	50	2	36658650
Pubmed	Differential cell-type-expression of CYFIP1 and CYFIP2 in the adult mouse hippocampus.	CYFIP1 CYFIP2	3.03e-05	6	50	2	31853374
Pubmed	Protein kinase B alpha/Akt1 regulates placental development and fetal growth.	RPS6KB1 NOS3	3.03e-05	6	50	2	12783884
Pubmed	Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition.	ZRSR2P1 ZRSR2	3.03e-05	6	50	2	33846634
Pubmed	The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation.	PIK3CA RPS6KB1	4.23e-05	7	50	2	31915252
Pubmed	Smaller Body Size, Early Postnatal Lethality, and Cortical Extracellular Matrix-Related Gene Expression Changes of Cyfip2-Null Embryonic Mice.	CYFIP1 CYFIP2	4.23e-05	7	50	2	30687000
Pubmed	CtIP-mediated resection is essential for viability and can operate independently of BRCA1.	EXO1 XRCC5	4.23e-05	7	50	2	24842372
Pubmed	A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA.	ZRSR2P1 ZRSR2	4.23e-05	7	50	2	9237760
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	TIGAR CAND1 LDB1 WDR11 RPS6KB1 VPS35L DDX56 MCF2L XRCC5 FARP2	4.31e-05	1489	50	10	28611215
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CYFIP1 CAND1 KMT2B WDR11 GLG1 DDX56 MORC2 DHX29 CYFIP2 FARP2	4.51e-05	1497	50	10	31527615
Pubmed	APOBEC3 deaminases induce hypermutation in human papillomavirus 16 DNA upon beta interferon stimulation.	IFNB1 APOBEC3F	5.64e-05	8	50	2	24227842
Pubmed	Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy.	ZRSR2P1 ZRSR2	5.64e-05	8	50	2	32371981
Pubmed	Extra-renal locations of the a4 subunit of H(+)ATPase.	ATP6V0A4 ATP6V0D2	5.64e-05	8	50	2	27368196
Pubmed	Vav GEFs are required for beta2 integrin-dependent functions of neutrophils.	VAV3 ITGB2	5.64e-05	8	50	2	15249579
Pubmed	Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion.	GLG1 ITGB2	5.64e-05	8	50	2	25892652
Pubmed	Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.	PIK3CA RPS6KB1	7.25e-05	9	50	2	11279232
Pubmed	Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer.	PIK3CA RPS6KB1	7.25e-05	9	50	2	21035469
Pubmed	Neurodevelopmental disorder-associated CYFIP2 regulates membraneless organelles and eIF2α phosphorylation via protein interactors and actin cytoskeleton.	CYFIP1 CYFIP2	7.25e-05	9	50	2	38981622
Pubmed	Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K and AKT and disrupts vascular integrity by activating VE-cadherin.	PIK3CA NOS3	9.05e-05	10	50	2	27522498
Pubmed	The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.	PIK3CA RPS6KB1	9.05e-05	10	50	2	15249583
Pubmed	Abi1 is essential for the formation and activation of a WAVE2 signalling complex.	CYFIP1 CYFIP2	9.05e-05	10	50	2	15048123
Pubmed	Role of polymorphisms of the inflammatory response genes and DC-SIGNR in genetic susceptibility to SARS and other infections.	IFNB1 NOS3	9.05e-05	10	50	2	18708672
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	CAND1 EXO1 DDX56 XRCC5 DHX29 URGCP NCOA5	1.01e-04	759	50	7	35915203
Pubmed	DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis.	MYO1E XRCC5 KPNB1	1.04e-04	63	50	3	37052853
Pubmed	Human osteoclast-like cells are formed from peripheral blood mononuclear cells in a coculture with SaOS-2 cells transfected with the parathyroid hormone (PTH)/PTH-related protein receptor gene.	PIK3CA RPS6KB1	1.10e-04	11	50	2	9927325
Pubmed	Dynamic SUMOylation of MORC2 orchestrates chromatin remodelling and DNA repair in response to DNA damage and drives chemoresistance in breast cancer.	XRCC5 MORC2	1.32e-04	12	50	2	36793866
Pubmed	MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.	CYFIP1 CAND1 MYO1E ITGB2 CYFIP2 KPNB1	1.55e-04	565	50	6	20458337
Pubmed	14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif.	EXO1 KPNB1	1.56e-04	13	50	2	22222486
Pubmed	Deficiency of the neurodevelopmental disorder-associated gene Cyfip2 alters the retinal ganglion cell properties and visual acuity.	CYFIP1 CYFIP2	1.56e-04	13	50	2	34508581
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	CYFIP1 CAND1 PUS1 DDX56 XRCC5 DHX29 CYFIP2 KPNB1 NCOA5	1.74e-04	1425	50	9	30948266
Pubmed	NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner.	PIK3CA RPS6KB1	1.82e-04	14	50	2	27119228
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	CYFIP1 CAND1 XRCC5 SEPTIN10 DHX29 CYFIP2 KPNB1	1.99e-04	847	50	7	35235311
Pubmed	Molecular architecture underlying fluid absorption by the developing inner ear.	ATP6V0A4 ATP6V0D2	2.10e-04	15	50	2	28994389
Pubmed	Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.	CYFIP1 WDR11 XRCC5 KPNB1	2.62e-04	215	50	4	30462309
Pubmed	EVA1A/TMEM166 Regulates Embryonic Neurogenesis by Autophagy.	PIK3CA RPS6KB1	2.72e-04	17	50	2	26905199
Pubmed	Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae.	VAV3 ITGB2	2.72e-04	17	50	2	21257963
Pubmed	Comparative mapping of the imprinted U2afbpL gene on mouse chromosome 11 and human chromosome 5.	ZRSR2P1 ZRSR2	2.72e-04	17	50	2	7956352
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	CYFIP1 GLG1 VPS35L XRCC5 M6PR GPAT4 CYFIP2 KPNB1	2.95e-04	1203	50	8	29180619
Pubmed	In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly.	CYFIP1 CYFIP2	3.05e-04	18	50	2	9463375
Pubmed	Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain.	MCF2L FARP2	3.05e-04	18	50	2	12799088
Pubmed	Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.	CAND1 LDB1 GLG1 XRCC5	3.16e-04	226	50	4	37839992
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	CYFIP1 CAND1 EPPK1 FASTKD1 VAV3 MCF2L FARP2	3.20e-04	916	50	7	32203420
Pubmed	Androglobin, a chimeric mammalian globin, is required for male fertility.	SEPTIN10 NOS3	3.41e-04	19	50	2	35700329
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	CYFIP1 GLG1 TENT5C MCF2L SEPTIN10 CYFIP2 UEVLD FARP2	3.66e-04	1242	50	8	30973865
Pubmed	BAP1 maintains chromosome stability by stabilizing DIDO1 in renal cell carcinoma.	EXO1 KPNB1	3.79e-04	20	50	2	32509391
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	CYFIP1 EPPK1 MYO1E WDR11 DDX56 XRCC5 KPNB1 NCOA5	3.96e-04	1257	50	8	36526897
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CYFIP1 CAND1 LDB1 RPS6KB1 XRCC5 CYFIP2 KPNB1	4.32e-04	963	50	7	28671696
Pubmed	Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.	PIK3CA VAV3 CYFIP2	4.47e-04	103	50	3	21706016
Pubmed	Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies.	CAND1 XRCC5 ITGB2 KPNB1	4.56e-04	249	50	4	30097533
Pubmed	The vacuolar (H+)-ATPases--nature's most versatile proton pumps.	ATP6V0A4 ATP6V0D2	4.59e-04	22	50	2	11836511
Pubmed	Proton translocation driven by ATP hydrolysis in V-ATPases.	ATP6V0A4 ATP6V0D2	4.59e-04	22	50	2	12788495
Pubmed	Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit genes.	ATP6V0A4 ATP6V0D2	4.59e-04	22	50	2	14580332
Pubmed	Neurotransmitter release: the dark side of the vacuolar-H+ATPase.	ATP6V0A4 ATP6V0D2	4.59e-04	22	50	2	14597263
Pubmed	Coupling of rotation and catalysis in F(1)-ATPase revealed by single-molecule imaging and manipulation.	ATP6V0A4 ATP6V0D2	4.59e-04	22	50	2	17662945
Pubmed	Variants of ADAMTS1 modify the effectiveness of statins in reducing the risk of myocardial infarction.	ITGB2 NOS3	5.48e-04	24	50	2	21037509
Pubmed	Genomic analysis of mouse retinal development.	LDB1 KMT2B GLG1 RPS6KB1 FASTKD1 MCF2L KPNB1	5.60e-04	1006	50	7	15226823
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	CAND1 GLG1 ATP6V0A4 ATP6V0D2 CYFIP2 KPNB1 UEVLD	5.94e-04	1016	50	7	19056867
Pubmed	Receptor-mediated endocytosis: the intracellular journey of transferrin and its receptor.	ATP6V0A4 ATP6V0D2	5.95e-04	25	50	2	2874839
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	CYFIP1 CAND1 EPPK1 GLG1 XRCC5 DHX29 M6PR KPNB1	6.89e-04	1367	50	8	32687490
Pubmed	Deletion of Pdcd5 in mice led to the deficiency of placenta development and embryonic lethality.	PIK3CA RPS6KB1	6.95e-04	27	50	2	28542142
Pubmed	Evidence that the transcriptional repressor ICER is regulated via the N-end rule for ubiquitination.	CAND1 KPNB1	7.48e-04	28	50	2	35227662
Pubmed	Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy.	PIK3CA RPS6KB1	8.02e-04	29	50	2	26633882
Pubmed	Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.	ZRSR2P1 ZRSR2	8.02e-04	29	50	2	32527007
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	CYFIP1 CAND1 GLG1 IL6ST CYFIP2 KPNB1 UEVLD	8.06e-04	1070	50	7	23533145
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	CAND1 WDR11 KPNB1	8.60e-04	129	50	3	23022380
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	TIGAR CYFIP1 CAND1 EPPK1 MYO1E GLG1 XRCC5 KPNB1	8.62e-04	1415	50	8	28515276
Pubmed	Genetic associations of brain structural networks in schizophrenia: a preliminary study.	PIK3CA NOS3	9.17e-04	31	50	2	20691427
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	CAND1 LDB1 MYO1E VPS35L DDX56 XRCC5 DHX29 KPNB1	9.66e-04	1440	50	8	30833792
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	CAND1 EPPK1 GLG1 DHX29 IL6ST	9.96e-04	533	50	5	25544563
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	WDR11 XRCC5 ACYP2 CYFIP2 KPNB1 NCOA5	1.03e-03	809	50	6	32129710
Interaction	RAC1 interactions	CYFIP1 MYO1E WDR11 PIK3CA RPS6KB1 DDX56 VAV3 MCF2L SEPTIN10 IL6ST CYFIP2 KPNB1	6.55e-06	1063	49	12	int:RAC1
Cytoband	7p13	DDX56 URGCP	8.39e-04	39	50	2	7p13
Cytoband	5q11.2	DHX29 IL6ST	1.49e-03	52	50	2	5q11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr7p13	DDX56 URGCP	1.55e-03	53	50	2	chr7p13
Cytoband	11p15.1	IGSF22 UEVLD	1.98e-03	60	50	2	11p15.1
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	VAV3 MCF2L FARP2	1.94e-04	66	31	3	722
GeneFamily	V-type ATPases	ATP6V0A4 ATP6V0D2	7.04e-04	23	31	2	415
GeneFamily	Zinc fingers CCCH-type	ZRSR2P1 ZRSR2	1.63e-03	35	31	2	73
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	VAV3 MCF2L FARP2	5.18e-03	206	31	3	682
ToppCell	LPS_only-Hematopoietic_Lymphocytic-Lymphocytic_NK/T-iNKT-MAIT\|LPS_only / Treatment groups by lineage, cell group, cell type	TIGAR MYO1E TENT5C VAV3 ITGB2 CYFIP2	9.38e-08	199	50	6	b62a756b5472972156d05051a58671a58bef1f16
Drug	Orotic Acid	PIK3CA RPS6KB1 NOS3	2.81e-06	13	50	3	ctd:D009963
Drug	fascaplysine	PIK3CA RPS6KB1 NOS3	3.57e-06	14	50	3	ctd:C069346
Disease	chromosome 15q11.2 deletion syndrome (implicated_via_orthology)	CYFIP1 CYFIP2	7.13e-06	3	46	2	DOID:0060393 (implicated_via_orthology)
Disease	alcohol dependence (implicated_via_orthology)	RPS6KB1 XRCC5	8.50e-05	9	46	2	DOID:0050741 (implicated_via_orthology)
Disease	Chronic Lymphocytic Leukemia	ZRSR2 PIK3CA FARP2	8.79e-05	55	46	3	C0023434
Disease	Hereditary Diffuse Gastric Cancer	PIK3CA PUS1 ATP6V0D2 M6PR NOS3	9.16e-05	293	46	5	C1708349
Disease	Stomach Neoplasms	PIK3CA PUS1 ATP6V0D2 M6PR NOS3	9.77e-05	297	46	5	C0038356
Disease	Malignant neoplasm of stomach	PIK3CA PUS1 ATP6V0D2 M6PR NOS3	1.02e-04	300	46	5	C0024623
Disease	Drug habituation	AGBL4 WDR11 AKAP7	7.75e-04	115	46	3	C0013170
Disease	Substance-Related Disorders	AGBL4 WDR11 AKAP7	7.75e-04	115	46	3	C0236969
Disease	Drug abuse	AGBL4 WDR11 AKAP7	7.75e-04	115	46	3	C0013146
Disease	Drug Use Disorders	AGBL4 WDR11 AKAP7	7.75e-04	115	46	3	C0013222
Disease	Drug Dependence	AGBL4 WDR11 AKAP7	7.75e-04	115	46	3	C1510472
Disease	Substance Dependence	AGBL4 WDR11 AKAP7	7.75e-04	115	46	3	C0038580
Disease	Substance Use Disorders	AGBL4 WDR11 AKAP7	7.75e-04	115	46	3	C0038586
Disease	Organic Mental Disorders, Substance-Induced	AGBL4 WDR11 AKAP7	7.75e-04	115	46	3	C0029231
Disease	Prescription Drug Abuse	AGBL4 WDR11 AKAP7	7.75e-04	115	46	3	C4316881
Disease	Substance abuse problem	AGBL4 WDR11 AKAP7	7.94e-04	116	46	3	C0740858
Disease	Hereditary non-polyposis colorectal cancer syndrome	PIK3CA EXO1	8.14e-04	27	46	2	C1112155
Disease	primary biliary cholangitis (biomarker_via_orthology)	RPS6KB1 NOS3	8.76e-04	28	46	2	DOID:12236 (biomarker_via_orthology)
Disease	Hereditary Nonpolyposis Colorectal Cancer	PIK3CA EXO1	9.40e-04	29	46	2	C1333990
Disease	Chloracne	EPPK1 ITGB2	1.22e-03	33	46	2	C0263454

Protein segments in the cluster

Peptide	Gene	Start	Entry
DYEVFGRVQGVCFRM	ACYP2	11	P14621
VCFRMYTEDEARKIG	ACYP2	21	P14621
RFGEEILYRIDLCSM	AKAP7	251	Q9P0M2
RDGFCFRMYTRERFE	DHX29	986	Q7Z478
VMLTCAFRYGRDDLE	ARR3	51	P36575
MYFQRNAIERFCGEV	CYFIP1	126	Q7L576
VCVEGRLYLEFMFDD	LDB1	176	Q86U70
EFVADFRLMLETCYR	KIAA2026	156	Q5HYC2
YQFRMEEIEGFRYRC	DDX56	416	Q9NY93
DDGLDIRKAAFECMY	CAND1	1076	Q86VP6
LRMDDYCRRKDDSYF	NCOA5	131	Q9HCD5
REGIFMEDTACFYLA	RPS6KB1	186	P23443
RAEVYLRKCTFDMFN	KMT2B	2511	Q9UMN6
MYFQRKAIERFCSEV	CYFIP2	126	Q96F07
CTKTREFERFQEMCY	PIK3CA	971	P42336
YAERREDLRGGFMLC	MORC2	51	Q9Y6X9
FDARDCRSAQEMFTY	NOS3	196	P29474
GMDRYLIYVDESREC	ITGB2	681	P05107
IIFSDYRLICGFMDD	GLG1	226	Q92896
GARVKIMDDEEFAYC	APOBEC3F	141	Q8IUX4
VCMEYGFTDFRGLLR	IGSF22	206	Q8N9C0
PFTEYVFRIRCMKED	IL6ST	291	P40189
KRYCFGEGLARMELF	CYP2A13	436	Q16696
ELSDIFYFCRKGMET	GPAT4	111	Q86UL3
RMDYLRECIFGEVKS	FASTKD1	831	Q53R41
NGRLEYCLKDRMNFD	IFNB1	46	P01574
YVMSFAFCFDREEDI	AGBL4	146	Q5VU57
RYRDAAVMAFGCILE	KPNB1	381	Q14974
GRCFLERMEDFQIYE	MCF2L	711	O15068
RLNLVECDYFGMEFQ	FARP2	76	O94887
DQVKMRGIDFFEFLC	TIGAR	126	Q9NQ88
MYCEEPFVREGLEFA	PUS1	266	Q9Y606
RCGYFDEEMNRILAD	EPPK1	1706	P58107
KMRVFERSVYFGDSC	PHAF1	231	Q9BSU1
FFLRREGMRQYGECL	RSPO2	61	Q6UXX9
LGDVFTEEKFRYMCI	EXO1	206	Q9UQ84
EEIKTLERYMCSRFF	TENT5C	261	Q5VWP2
FLREMGQFYEAESCL	URGCP	616	Q8TCY9
ERRYECSECGKLFMD	ZNF749	351	O43361
FGKLVYERIFSMCVD	VPS35L	241	Q7Z3J2
RGKVQDCFYLFEMDS	M6PR	161	P20645
LYRRCKLEEMGFTDV	SEPTIN10	321	Q9P0V9
RICRGNVYLKFSEMD	ATP6V0A4	191	Q9HBG4
MEFDCEGLRRLLGKY	UEVLD	1	Q8IX04
DFRVMEKDRANCPFY	ZRSR2P1	166	Q15695
FTTFGMEQCRRDDYD	ZRSR2P1	211	Q15695
SMRYFDRAALFVEAC	WDR11	1146	Q9BZH6
DFRVMEKDRANCPFY	ZRSR2	161	Q15696
FTTFGMEQCRRDDYD	ZRSR2	206	Q15696
NKEYPERFIECFMAE	TKTL1	326	P51854
YFMKSIDCIRAFREE	XRCC5	631	P13010
DTEMRKRLCGEFEYF	ATP6V0D2	71	Q8N8Y2
GIAIARYDFCARDMR	VAV3	791	Q9UKW4
VSYDMDGFCERNRDV	MYO1E	511	Q12965
DGFCERNRDVLFMDL	MYO1E	516	Q12965