Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
HumanPhenoTongue muscle weakness

SH3TC2 PLCB4 ATP13A2

1.95e-0513223HP:0000183
HumanPhenoPsychotic episodes

MTHFR USP48 ATP13A2

5.47e-0518223HP:0000725
DomainBeta-tubulin_BS

TUBB6 TUBB3

3.91e-0410562IPR013838
DomainBeta_tubulin

TUBB6 TUBB3

3.91e-0410562IPR002453
DomainTUBULIN_B_AUTOREG

TUBB6 TUBB3

4.77e-0411562PS00228
Domain-

TUBB6 TUBB3

1.62e-03205623.30.1330.20
Domain-

TUBB6 TUBB3

1.79e-03215621.10.287.600
DomainTubulin_C

TUBB6 TUBB3

1.96e-0322562SM00865
DomainTubulin_C

TUBB6 TUBB3

1.96e-0322562PF03953
DomainTubulin/FtsZ_2-layer-sand-dom

TUBB6 TUBB3

1.96e-0322562IPR018316
Domain-

TUBB6 TUBB3

1.96e-03225623.40.50.1440
DomainTubulin_C

TUBB6 TUBB3

2.15e-0323562IPR023123
DomainTUBULIN

TUBB6 TUBB3

2.15e-0323562PS00227
DomainTubulin

TUBB6 TUBB3

2.15e-0323562IPR000217
DomainTub_FtsZ_C

TUBB6 TUBB3

2.15e-0323562IPR008280
DomainTubulin

TUBB6 TUBB3

2.15e-0323562SM00864
DomainTubulin_CS

TUBB6 TUBB3

2.15e-0323562IPR017975
DomainTubulin_FtsZ_GTPase

TUBB6 TUBB3

2.34e-0324562IPR003008
DomainTubulin

TUBB6 TUBB3

2.34e-0324562PF00091
PathwayKEGG_GAP_JUNCTION

TUBB6 TUBB3 EGF PLCB4

1.89e-0490454M4013
PathwayREACTOME_AGGREPHAGY

TUBB6 TUBB3 DYNC1H1

2.02e-0436453MM15669
PathwayKEGG_MEDICUS_REFERENCE_RAB7_REGULATED_MICROTUBULE_MINUS_END_DIRECTED_TRANSPORT

TUBB6 TUBB3 DYNC1H1

3.43e-0443453M47773
PathwayREACTOME_AGGREPHAGY

TUBB6 TUBB3 DYNC1H1

3.67e-0444453M29830
PathwayREACTOME_COPI_INDEPENDENT_GOLGI_TO_ER_RETROGRADE_TRAFFIC

TUBB6 TUBB3 DYNC1H1

4.76e-0448453MM15353
PathwayREACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION

TUBB6 LGMN TUBB3 DYNC1H1

5.00e-04116454MM14855
PathwayBIOCARTA_CBL_PATHWAY

EGF SH3KBP1

5.38e-0411452MM1360
PathwayREACTOME_HSP90_CHAPERONE_CYCLE_FOR_STEROID_HORMONE_RECEPTORS_SHR_IN_THE_PRESENCE_OF_LIGAND

TUBB6 TUBB3 DYNC1H1

6.02e-0452453MM14949
PathwayREACTOME_COPI_INDEPENDENT_GOLGI_TO_ER_RETROGRADE_TRAFFIC

TUBB6 TUBB3 DYNC1H1

6.37e-0453453M27651
PathwayBIOCARTA_CBL_PATHWAY

EGF SH3KBP1

6.44e-0412452M16973
PathwayREACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION

TUBB6 LGMN TUBB3 DYNC1H1

6.83e-04126454M705
PathwayREACTOME_HSP90_CHAPERONE_CYCLE_FOR_STEROID_HORMONE_RECEPTORS_SHR_IN_THE_PRESENCE_OF_LIGAND

TUBB6 TUBB3 DYNC1H1

7.88e-0457453M27251
Pubmed

Gender influences the class III and V β-tubulin ability to predict poor outcome in colorectal cancer.

TUBB6 TUBB3

2.83e-06259222438565
Pubmed

Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors.

GHSR SIGMAR1

2.83e-06259229876881
Pubmed

EGF-induced urokinase plasminogen activator receptor promotes epithelial to mesenchymal transition in human gastric cancer cells.

EGF PLAUR

2.83e-06259228849196
Pubmed

Full-length soluble urokinase plasminogen activator receptor down-modulates nephrin expression in podocytes.

NPHS1 PLAUR

2.83e-06259226380915
Pubmed

Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons.

GHSR CACNA1A

1.69e-05459226283199
Pubmed

FOCAD loss impacts microtubule assembly, G2/M progression and patient survival in astrocytic gliomas.

TUBB6 TUBB3

2.82e-05559231473790
Pubmed

CD2AP regulates SUMOylation of CIN85 in podocytes.

NPHS1 SH3KBP1

2.82e-05559222203040
Pubmed

CIN85/RukL is a novel binding partner of nephrin and podocin and mediates slit diaphragm turnover in podocytes.

NPHS1 SH3KBP1

2.82e-05559220457601
Pubmed

LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein.

TUBB3 DYNC1H1

4.23e-05659218784752
Pubmed

Spatiotemporal Role of Transforming Growth Factor Beta 2 in Developing and Mature Mouse Hindbrain Serotonergic Neurons.

TUBB3 FEV

4.23e-05659231619968
Pubmed

EGF stimulates uPAR expression and cell invasiveness through ERK, AP-1, and NF-kappaB signaling in human gastric carcinoma cells.

EGF PLAUR

4.23e-05659219020743
Pubmed

The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas.

TUBB3 SH2D3C

5.91e-05759220603213
Pubmed

Analysis of polymorphism in renin angiotensin system and other related genes in South Indian chronic kidney disease patients.

NPHS1 MTHFR

5.91e-05759219520069
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

TAOK2 TUBB6 SH3KBP1 DYNC1H1 FBXO2

6.85e-0525159527507650
Pubmed

Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors.

TUBB3 EGF

7.87e-05859215509736
Pubmed

Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix.

EGF SH3KBP1

7.87e-05859216407834
Pubmed

Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors.

EGF SH3KBP1

7.87e-05859211894095
Pubmed

A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation.

NPHS1 TUBB3

7.87e-05859227180624
Pubmed

UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death.

TUBB3 UTY

7.87e-05859236412518
Pubmed

Mutations in the β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities.

TUBB6 TUBB3

7.87e-05859223246003
Pubmed

Mutations in dynein link motor neuron degeneration to defects in retrograde transport.

TUBB3 DYNC1H1

7.87e-05859212730604
Pubmed

Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.

EGF SIGMAR1 MTHFR

9.66e-055259318583979
Pubmed

Ataxin-3 promotes genome integrity by stabilizing Chk1.

TUBB3 DYNC1H1

1.01e-04959228180282
Pubmed

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity.

TUBB3 UTY

1.01e-04959222949634
Pubmed

PEX14 is required for microtubule-based peroxisome motility in human cells.

TUBB6 TUBB3 DYNC1H1

1.08e-045459321525035
Pubmed

Proteinase expression in early mouse embryos is regulated by leukaemia inhibitory factor and epidermal growth factor.

EGF PLAUR

1.54e-04115927743917
Pubmed

Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation.

EGF SH3KBP1

1.54e-041159215962011
Pubmed

Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients.

EGF MTHFR

1.85e-041259216407418
Pubmed

USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation.

TUBB3 DYNC1H1

1.85e-041259229293652
Pubmed

The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis.

TUBB6 TUBB3

1.85e-041259215331610
Pubmed

Identification of candidate proteins binding to prion protein.

MTHFR FBXO2

1.85e-04125929173930
Pubmed

HIV-1 rev depolymerizes microtubules to form stable bilayered rings.

TUBB6 TUBB3

2.18e-041359210908577
Pubmed

Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors.

EGF SH3KBP1

2.18e-041359212218189
Pubmed

Fbxo2VHC mouse and embryonic stem cell reporter lines delineate in vitro-generated inner ear sensory epithelia cells and enable otic lineage selection and Cre-recombination.

TUBB3 FBXO2

2.18e-041359230179592
Pubmed

HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim.

TUBB6 TUBB3

2.54e-041459212486001
Pubmed

Ascl1/Mash1 is required for the development of central serotonergic neurons.

TUBB3 FEV

2.54e-041459215133515
Pubmed

IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration.

ELP2 DYNC1H1

2.93e-041559218303054
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

EPN3 NPHS1 TUBB6 SCRN2 EGF CRNN TTYH3 DYNC1H1

3.06e-04101659819056867
Pubmed

Protein interaction discovery using parallel analysis of translated ORFs (PLATO).

SH2D3C PLAUR TTYH3

3.22e-047859323503679
Pubmed

The SRC homology 2 domain protein Shep1 plays an important role in the penetration of olfactory sensory axons into the forebrain.

TUBB3 SH2D3C

3.34e-041659220881139
Pubmed

Deletion of RIC8A in neural precursor cells leads to altered neurogenesis and neonatal lethality of mouse.

TUBB3 ZFPM2

3.34e-041659225641781
Pubmed

Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing.

TUBB3 TNRC6B

4.25e-041859230111840
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

TUBB6 LGMN TUBB3 EGF TMC4 TTYH3 DYNC1H1 STK25

4.32e-04107059823533145
Pubmed

Inactivation of the GATA Cofactor ZFPM1 Results in Abnormal Development of Dorsal Raphe Serotonergic Neuron Subtypes and Increased Anxiety-Like Behavior.

FEV ZFPM2

4.75e-041959233046550
Pubmed

Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation.

TUBB3 FEV

4.75e-041959221068058
Pubmed

ARX regulates cortical intermediate progenitor cell expansion and upper layer neuron formation through repression of Cdkn1c.

TUBB6 TUBB3

4.75e-041959223968833
Pubmed

Neurogenin3 restricts serotonergic neuron differentiation to the hindbrain.

TUBB3 FEV

5.27e-042059225392491
Pubmed

Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.

TUBB3 DYNC1H1

5.27e-042059236551904
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TAOK2 EPN3 STK10 MTHFR TTYH3 MARVELD3 ATP13A2 DYNC1H1

5.34e-04110559835748872
Pubmed

Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain.

TUBB3 FEV

5.82e-042159219542360
Pubmed

Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal Function but Is Essential for Timely Axon Regeneration.

TUBB6 TUBB3

5.82e-042159230110642
Pubmed

The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex.

MAGEA1 TRIM41

5.82e-042159225590999
Pubmed

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.

TRIM41 JRK SH3KBP1 GSPT1

5.97e-0422659431452512
Pubmed

Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity.

TUBB6 TUBB3

6.39e-042259223826228
Pubmed

Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression.

TUBB6 TUBB3

6.39e-042259216526095
Pubmed

Bcl11a (Ctip1) Controls Migration of Cortical Projection Neurons through Regulation of Sema3c.

TUBB3 ZFPM2

6.39e-042259226182416
Pubmed

ISL1 controls pancreatic alpha cell fate and beta cell maturation.

TUBB3 FEV

6.39e-042259236899442
Pubmed

FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis.

TUBB3 ZFPM2

6.39e-042259222031906
Pubmed

TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology.

TUBB6 TUBB3

6.39e-042259230446499
Pubmed

A novel role for cilia-dependent sonic hedgehog signaling during submandibular gland development.

TUBB3 EGF

7.00e-042359229532549
Pubmed

KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer.

TUBB6 TUBB3 DYNC1H1

7.48e-0410459336055981
Pubmed

Loss of Fgf9 in mice leads to pancreatic hypoplasia and asplenia.

TUBB3 FEV

7.62e-042459237096042
Pubmed

Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.

CACNA1A TTYH3

7.62e-042459222534482
Pubmed

The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.

TUBB3 SIGMAR1 ELP2 ABHD17C

8.07e-0424559419521500
Pubmed

Gata2 and Gata3 regulate the differentiation of serotonergic and glutamatergic neuron subtypes of the dorsal raphe.

TUBB3 FEV

9.66e-042759227789623
Pubmed

Maternal DNA Methylation Regulates Early Trophoblast Development.

STK10 PLCB4

1.04e-032859226812015
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TAOK2 CACNA1A TUBB6 SH3KBP1 TNRC6B DYNC1H1 FBXO2

1.19e-0396359728671696
Pubmed

Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement.

TUBB6 TUBB3

1.19e-033059225864199
Pubmed

Large-scale identification of human genes implicated in epidermal barrier function.

EGF SH2D3C

1.19e-033059217562024
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

KIAA1671 STK10 LGMN PLCB4 TTYH3 GSPT1

1.36e-0371959635337019
Pubmed

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.

TUBB6 STK10 TUBB3 DYNC1H1

1.39e-0328459429459677
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

TAOK2 MAGEA1 TUBB6 GATD3 SH3KBP1 MARVELD3 USP48 FBXO2

1.47e-03129359815342556
Pubmed

Genome-wide association study of antibody response to smallpox vaccine.

FEV ABHD17C

1.53e-033459222542470
Pubmed

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.

TUBB3 DYNC1H1

1.53e-033459225915474
Pubmed

HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.

DYNC1H1 ZNF169

1.53e-033459225925205
Pubmed

Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking.

TUBB6 TUBB3

1.62e-033559222337587
Cytoband12p13.33

ITFG2 B4GALNT3

2.74e-041959212p13.33
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZSCAN29 ZNF671 ZFHX2 ZNF213 ZNF691 ZNF169 ZFPM2

1.05e-0371841728
GeneFamilyTubulins

TUBB6 TUBB3

1.58e-0326412778
ToppCellIIH-CD8-CD4_Treg|IIH / Condition, Cell_class and T cell subcluster

TAOK2 ZNF213 BRICD5 ZNF691 FBXO2

4.07e-06180595d1a8b25115c80e5a5bd0b8244167a98250ab9778
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

KIAA1671 SH2D3C EXOC3L1 PLCB4 ZFPM2

5.30e-061905956e6ce6dd549d1c38cfef5b3f8be06ab01ce344b7
ToppCellLPS_only-Endothelial-Endothelial-Gen_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIAA1671 SH2D3C EXOC3L1 PLCB4 ZFPM2

5.72e-06193595af5108260783e69a7d67896c5bf64f862525926d
ToppCellLPS_only-Endothelial|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIAA1671 SH2D3C EXOC3L1 PLCB4 ZFPM2

5.87e-0619459558f069efdefa0366033764446b9d6ffd4a17807e
ToppCellLPS_only-Endothelial-Endothelial|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIAA1671 SH2D3C EXOC3L1 PLCB4 ZFPM2

5.87e-06194595bfd92ec75facb0ba55c31e5f2e089d983b3d0169
ToppCellBronchial-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KIAA1671 UNC5A SH2D3C PLCB4 ZFPM2

6.48e-06198595b3a020522e064bb61949d38e442f24026e339364
ToppCellBronchial-NucSeq-Endothelial-Endothelia_lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KIAA1671 UNC5A SH2D3C PLCB4 ZFPM2

6.48e-06198595fc4b7c3ad52bc5c8b40fa04a156bfbb58afa2872
ToppCelldroplet-Lung-nan-21m-Myeloid-Intermediate_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TUBB6 STK10 EGF PLAUR

6.02e-051605940b8151037b28f52a21918856a1e9336e8d5edb90
ToppCelldroplet-Lung-nan-21m-Myeloid-intermediate_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TUBB6 STK10 EGF PLAUR

6.02e-051605944738d0c73d8c3508e5b5beb6c61e0ad551d9b949
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TUBB6 UNC5A SH2D3C ZFPM2

6.63e-05164594a784f47f67a5eda84d58ad7d9400e3978edbb487
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TUBB6 UNC5A SH2D3C ZFPM2

6.63e-051645941a1795969673232191425dde84ab24ee6a98143f
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TUBB6 UNC5A SH2D3C ZFPM2

6.63e-051645948f074940afdbda88a4b697a7ddc687e09a4b818b
ToppCellfacs-Marrow-T_cells-18m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LGMN MARVELD3 FBXO2 CHRND

8.15e-05173594e0cf99ddbe6e9eab05d7bf89e9aa124850c6a807
ToppCellfacs-Marrow-T_cells-18m-Hematologic-Unknown_Progenitor|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LGMN MARVELD3 FBXO2 CHRND

8.33e-051745943b1ee39e85e5f0d6b17fb3051dbfae66cb2be6ee
ToppCellControl-Myeloid-MoAM2,_CCL18|Control / Condition, Lineage and Cell class

LGMN TUBB3 KCNJ5 TTYH3

8.33e-051745944c64ff5666812fb4efa440ba4faeca51d916d68e
ToppCellfacs-Heart-RA-24m-Myeloid-macrophage|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPN3 UNC5A PLAUR TMC4

9.70e-05181594c68d272eb41f81bd8ea4d0360733a2396bc87037
ToppCellfacs-Heart-RA-24m-Myeloid-macrophage|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPN3 UNC5A PLAUR TMC4

9.70e-051815945e5eb89f224ee48065a328ade030cbc4dcdcac12
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

UNC5A LGMN PLAUR TTYH3

1.01e-04183594745271bfe15e94a58157cd97d771e610f964341b
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TUBB6 LGMN PLCB4 ATP13A2

1.01e-041835943b123571e10c132227aff65648b4b3c6acb4bd00
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TUBB6 LGMN PLCB4 ATP13A2

1.01e-04183594df6fd0927b6e4cf9a1583969a68096e4bccfbace
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-Progenitor_(NEUROG3+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A FEV MARVELD3 CHRND

1.06e-041855942088e82e0febdcf05618d3db913d00e2e87812f4
ToppCellfacs-Heart-LA-24m-Myeloid-macrophage|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCRN2 TMC4 MARVELD3 FBXO2

1.08e-04186594246503fd4e6ae24041c606b069eb5fb313e60f73
ToppCellfacs-Heart-LA-24m-Myeloid-macrophage|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCRN2 TMC4 MARVELD3 FBXO2

1.08e-04186594ef93ac469eb4f63db036f14b442c1503b8c6de38
ToppCellsystemic_lupus_erythematosus-flare-Myeloid-plasmacytoid_dendritic_cell-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

LGMN ZNF213 ATP13A2 UTY

1.10e-04187594d3563bb087e476baea5b59389e4d34d0ff98cac5
ToppCellLeuk-UTI-Myeloid-pDC|Leuk-UTI / Disease, Lineage and Cell Type

TUBB6 LGMN PLCB4 ATP13A2

1.10e-04187594e3035b1f65ab12b8f01799b8e5d6633b9b584a06
ToppCelldroplet-Kidney-KIDNEY-1m-Endothelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNJ5 EXOC3L1 PLAUR FEV

1.12e-0418859451c6796a9488c056a10d048082015342c2e037f9
ToppCelldroplet-Kidney-KIDNEY-1m-Endothelial-kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNJ5 EXOC3L1 PLAUR FEV

1.12e-04188594b651024d58ed1bcfe0d80b21755f8bf709eda81f
ToppCellEndothelial-endothelial_cell_of_lymph_vessel|World / Lineage, Cell type, age group and donor

KIAA1671 SH2D3C PLCB4 ZFPM2

1.12e-0418859480910dcbb51990f2baed240f319456c0d3fa2065
ToppCellLPS-antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIAA1671 SH2D3C EXOC3L1 PLCB4

1.12e-04188594789d1be574e693d7bdd488f3c72c6df788e47b47
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

KIAA1671 SH2D3C PLCB4 ZFPM2

1.12e-04188594aeecbc057dc823f8fcea8a98f18d213bacc7f4db
ToppCell3'_v3-lymph-node_spleen-Myeloid_Dendritic-pDC|lymph-node_spleen / Manually curated celltypes from each tissue

TUBB6 LGMN PLAUR ATP13A2

1.15e-041895946c2ace61a7d62bcf7e76b73e2da8b722d03e713b
ToppCellwk_20-22-Hematologic-Myeloid-APOE+_Mac2|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

LGMN KCNJ5 PLAUR TTYH3

1.15e-04189594e189ef6066f87177d758f0e3ed9a17e01031a391
ToppCellControl-Endothelial-Endothelial-Alv_Gen_Intermediate|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIAA1671 SH2D3C EXOC3L1 PLCB4

1.15e-041895945d7ae1ead7f4fbaeec26f651833c9c2106e1e4d1
ToppCellControl-Myeloid-pDC|Control / Disease group, lineage and cell class

TUBB6 LGMN PLCB4 ATP13A2

1.15e-0418959446770b99da42f11f10cfc67cea8562342d60b867
ToppCellPBMC-Control-Myeloid-pDC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

TUBB6 LGMN PLCB4 ATP13A2

1.17e-04190594adffa93635da10251f28b2089fd96b189775c8b4
ToppCellPBMC-Control-Myeloid-pDC-pDC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TUBB6 LGMN PLCB4 ATP13A2

1.17e-041905949a91bf1ea105029e6412d0d9060bca325299ce26
ToppCellPBMC-Control-Myeloid-pDC-pDC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

TUBB6 LGMN PLCB4 ATP13A2

1.17e-0419059439c8ddc2639bf3e986dae11fbae61a735614b604
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

KIAA1671 SH2D3C PLCB4 ZFPM2

1.17e-041905940e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCellPBMC-Control-Myeloid-pDC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TUBB6 LGMN PLCB4 ATP13A2

1.17e-041905942c1c079fd411c03bc3f383aa927eea9446716960
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIAA1671 SH2D3C EXOC3L1 PLCB4

1.17e-04190594a3c6eec6df052105ab78b7e3c78f94218d5912eb
ToppCellPBMC-Control-Myeloid-pDC-pDC-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TUBB6 LGMN PLCB4 ATP13A2

1.17e-04190594a95aea3aa707fc4574810706341a5f32b3d00209
ToppCellPBMC-Control-Myeloid-pDC-pDC-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TUBB6 LGMN PLCB4 ATP13A2

1.17e-0419059418dfa84c62dcf081ce9958a71e76a394ec0968e4
ToppCellLPS-IL1RA-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIAA1671 SH2D3C EXOC3L1 PLCB4

1.17e-04190594106ea0bb7b99c697ffc5443d72343df2484250c7
ToppCellLPS-IL1RA+antiTNF-Endothelial|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIAA1671 SH2D3C EXOC3L1 PLCB4

1.22e-0419259404f5a2e3dd6beff027b89d66eefdd92036e041af
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIAA1671 SH2D3C EXOC3L1 PLCB4

1.22e-04192594c07d7b40b2aa4eb27ac85801c014a656e2fd01dc
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIAA1671 SH2D3C EXOC3L1 PLCB4

1.24e-04193594e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCellLPS-antiTNF-Endothelial-Endothelial|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIAA1671 SH2D3C EXOC3L1 PLCB4

1.24e-0419359402f633b016ab19bfa65bfd0cf32f000549a62148
ToppCellControl-Endothelial-Endothelial|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIAA1671 SH2D3C EXOC3L1 PLCB4

1.24e-04193594aff0649c73c634bc6ff0dc7759b4693a9236bf05
ToppCellControl-Endothelial|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIAA1671 SH2D3C EXOC3L1 PLCB4

1.24e-04193594c5f9fe03e64c211d4bcd4959e5b32f14841e336a
ToppCellLPS-antiTNF-Endothelial|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIAA1671 SH2D3C EXOC3L1 PLCB4

1.24e-041935945122b1ffba42de190061be34ecdc6176f84e56a3
ToppCellControl-Myeloid-Macrophage|Myeloid / Disease state, Lineage and Cell class

LGMN SH3KBP1 PLAUR TTYH3

1.24e-041935942a6d531abd34df20941cf3dac4fdfb1621a1bde6
ToppCellfacs-Trachea-nan-3m-Epithelial|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPN3 TEKT1 TMC4 MARVELD3

1.27e-041945943701ca87c6dc9ccd7b4146e56371546174d26c36
ToppCellfacs-Trachea-nan-3m-Epithelial-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPN3 TEKT1 TMC4 MARVELD3

1.27e-0419459465f9bf126be26114c2c3f4c46d48318986212a92
ToppCellnormal-na-Myeloid-plasmacytoid_dendritic_cell-female|normal / PBMC cell types (v2) per disease, treatment status, and sex

TUBB6 LGMN PLCB4 ATP13A2

1.27e-0419459474545942aded51a0f4ee96054b4ce12c4d99a8a0
ToppCellLPS-IL1RA-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIAA1671 SH2D3C EXOC3L1 PLCB4

1.27e-0419459443f92b0533e26633dc94cce554045d641ef8fd76
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIAA1671 EXOC3L1 PLCB4 ZFPM2

1.27e-041945940b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCellLPS-IL1RA-Endothelial-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIAA1671 SH2D3C EXOC3L1 PLCB4

1.27e-041945941d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

STK10 LGMN KCNJ5 TTYH3

1.27e-0419459445708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

STK10 LGMN KCNJ5 TTYH3

1.29e-04195594247803cf58c6d9c561a52aa34e581188ddad197e
ToppCellChildren_(3_yrs)-Endothelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

KIAA1671 SH2D3C PLCB4 ZFPM2

1.29e-04195594094cf6591daa5ffad36e44122b6f524a3a34c2fd
ToppCellEnterocyte-C_05|Enterocyte / shred on cell type and cluster

SH3KBP1 PLAUR B4GALNT3 ABHD17C

1.32e-04196594c307e5a70186567c62da938caa21749dc0e929d0
ToppCellEndothelial|World / Lineage, Cell type, age group and donor

KIAA1671 SH2D3C PLCB4 ZFPM2

1.32e-0419659496c6d78482a130ce4e29f6629972a06d10d7530e
ToppCellnucseq-Endothelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KIAA1671 SH2D3C PLCB4 ZFPM2

1.34e-04197594ebf9be068eaa658493fa7884fd19f34642922acb
ToppCell3'_v3-Lung-Myeloid_Mac-Intermediate_macrophages|Lung / Manually curated celltypes from each tissue

TUBB6 TUBB3 PLAUR TTYH3

1.34e-04197594bcb4dc17dae705bd84ea6a2842d6b107562baeb7
ToppCellSmart-seq2-thymus_(Smart-seq2)-myeloid|thymus_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

STK10 LGMN PLAUR TTYH3

1.37e-041985942e470249edc7cf85bed550795ff84cbef22895c0
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

KIAA1671 CACNA1A TUBB3 ZFHX2

1.37e-04198594d6812494874be0c14361ac2ac3e418b335bb8f55
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

STK10 LGMN PLAUR TTYH3

1.40e-04199594667b8b47a5b388506e3177b46747267fad8024f6
ToppCellParenchymal-10x5prime-Immune_Myeloid-Macrophage_other-Macro_CHIT1|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LGMN KCNJ5 PLAUR TTYH3

1.40e-04199594f987f48970aec46156b80656e49b9f3604f3758c
ToppCellParenchymal-NucSeq-Immune_Myeloid-Monocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

STK10 SH2D3C PLAUR TTYH3

1.42e-04200594fd72fe6565e2f4885481991492d58c323ab1ad40
ToppCellMild-Myeloid-Macrophages-FCN1-SPP1+|Mild / Condition, Lineage, Cell class and cell subclass

LGMN KCNJ5 PLAUR TTYH3

1.42e-04200594e5afd8e2cb2c63899d49fe17011f474d20bb06ea
ToppCellBronchial-10x5prime-Immune_Myeloid-Macrophage_other|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LGMN KCNJ5 PLAUR TTYH3

1.42e-042005942d2835f97e0ff4f99d384f18e10876575f6bdefd
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_ALM_Nxph2_Sla|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NPHS1 ZFPM2 IL27RA

2.89e-04975930d68bf2dfb9c221375b70b055f735536afb18f65
Diseasemigraine with aura (is_implicated_in)

CACNA1A MTHFR

5.47e-056572DOID:10024 (is_implicated_in)
DiseaseChildhood Absence Epilepsy

CACNA1A JRK

7.65e-057572C4281785
DiseaseEpilepsy, Minor

CACNA1A JRK

7.65e-057572C4552765
DiseaseAbsence Epilepsy

CACNA1A JRK

7.65e-057572C0014553
DiseaseAkinetic Petit Mal

CACNA1A JRK

7.65e-057572C0001890
DiseaseEpilepsy, Absence, Atypical

CACNA1A JRK

7.65e-057572C0751124
DiseaseAbsence Seizure Disorder

CACNA1A JRK

7.65e-057572C4553705
DiseaseJuvenile Absence Epilepsy

CACNA1A JRK

7.65e-057572C4317339
Diseasemigraine (is_implicated_in)

CACNA1A MTHFR

1.31e-049572DOID:6364 (is_implicated_in)
Diseasefacial paralysis (implicated_via_orthology)

TUBB6 TUBB3

1.63e-0410572DOID:13934 (implicated_via_orthology)
Diseasecomplex cortical dysplasia with other brain malformations 7 (implicated_via_orthology)

TUBB6 TUBB3

1.63e-0410572DOID:0090132 (implicated_via_orthology)
Diseaseptosis (implicated_via_orthology)

TUBB6 TUBB3

1.63e-0410572DOID:0060260 (implicated_via_orthology)
Diseasetubulinopathy (implicated_via_orthology)

TUBB6 TUBB3

1.63e-0410572DOID:0112227 (implicated_via_orthology)
Diseaseautosomal dominant nonsyndromic deafness (is_implicated_in)

USP48 EPHA10

1.99e-0411572DOID:0050564 (is_implicated_in)
DiseaseHyperhomocysteinemia

NPHS1 MTHFR

1.99e-0411572C0598608
Diseasecerebellar ataxia, mental retardation and dysequlibrium syndrome (implicated_via_orthology)

TUBB6 TUBB3

2.39e-0412572DOID:0050997 (implicated_via_orthology)
Diseaseadvanced glycosylation end product-specific receptor, soluble measurement

B4GALNT3 ZFPM2

2.82e-0413572EFO_0020131
Diseasetetralogy of Fallot (is_implicated_in)

MTHFR ZFPM2

2.82e-0413572DOID:6419 (is_implicated_in)
DiseaseUterine leiomyoma, estrogen-receptor positive breast cancer

TNRC6B ZFPM2

5.50e-0418572EFO_1000649, HP_0000131
DiseaseKidney Diseases

NPHS1 EGF MTHFR

6.68e-0488573C0022658
Diseasenephrotic syndrome (implicated_via_orthology)

NPHS1 SH3KBP1

9.85e-0424572DOID:1184 (implicated_via_orthology)
DiseaseAlcoholic Intoxication, Chronic

GHSR EGF SIGMAR1 MTHFR

1.80e-03268574C0001973
Diseasepeptic ulcer disease

JRK ZNF169

1.86e-0333572MONDO_0004247

Protein segments in the cluster

PeptideGeneStartEntry
WEGEAERGKAGDPHR

CACNA1A

916

O00555
ALDGEVAEWGREHGP

EXOC3L1

396

Q86VI1
DPEGFTENGEWEIVH

CHRND

201

Q07001
QAPGRGWHGEEEVVA

B4GALNT3

581

Q6L9W6
GWHGEEEVVAAAGQE

B4GALNT3

586

Q6L9W6
GWFEELGAEPLEIHG

BRICD5

211

Q6PL45
PALAWEREDTHGGVG

DNM1P46

111

Q6ZS02
IAWEGGHGEFKLTDP

FEV

66

Q99581
EHEKEVRSWQGDGSP

EPN3

251

Q9H201
GDLDHVGDQEWIPCV

KCNJ5

116

P48544
EWPGLDEGHVRAGQS

NPHS1

246

O60500
DGEEGIPVQVDGEAW

DGKK

1001

Q5KSL6
LRGDPIGDQWEEEEG

MTHFR

156

P42898
GGHAPEEEIWEELSV

MAGEA1

206

P43355
GRGEEDSVAQWGDHP

KIAA1671

1381

Q9BY89
EVTVGHEQEEGGKWP

GATD3B

191

A0A0B4J2D5
GVETDDWDGPGELEV

ZFPM2

91

Q8WW38
GLVPEGGVEEERDHW

FBXO2

96

Q9UK22
RGDPGEGEEVAWEQA

JRK

476

O75564
GEPLEHVVDWARDGD

IL27RA

346

Q6UWB1
NGWEEISGVDEHDRP

EPHA10

56

Q5JZY3
GDRQPTVVGEEWVDD

CRNN

431

Q9UBG3
WEHKEEISEAEPGGG

GSPT1

21

P15170
RWEELGEGPEHLTGQ

ITFG2

156

Q969R8
GGEEEWVDSSELVPG

ATP13A2

301

Q9NQ11
LVGVEHENGTDPWDT

GHSR

181

Q92847
EEGVDVPEGLAVDWI

EGF

551

P01133
EPLWVEGAGHNDIEL

ABHD17C

296

Q6PCB6
DAGPRAGEHGVWEKP

MARVELD3

96

Q96A59
EVTVGHEQEEGGKWP

GATD3

191

P0DPI2
EDVLGKGWENHVEGQ

DYNC1H1

666

Q14204
GHFDGVQDLVWDPEG

ELP2

386

Q6IA86
LHDIRKPEGQGWESG

FTH1P19

46

P0C7X4
GKEVIWHGRTNDEPA

UTY

1261

O14607
EEVEAVGAGAGWDTP

TRIM41

71

Q8WV44
CWDGKGEDQEPIITH

PLCB4

361

Q15147
GNEAVWTKEPVGEGE

SCRN2

96

Q96FV2
VGDIIEVVGEVEEGW

SH3KBP1

121

Q96B97
TVVHGPGEATAVEWG

SIGMAR1

151

Q99720
SIPLRDGEDHGVWAG

TEKT1

396

Q969V4
HGSLVDEEVWGLPEE

TAOK2

831

Q9UL54
EVRPGRAWEEHQAVG

SH3TC2

401

Q8TF17
EHPRWEENCEEEAGG

SYCE2

26

Q6PIF2
IDGEAEDGEQGPIWT

STK25

306

O00506
GLRPGCWHGVEDEEV

ZNF671

126

Q8TAW3
DVVTHWIQEGEEGRP

PLAUR

146

Q03405
WIQEGEEGRPKDDRH

PLAUR

151

Q03405
EEGEGGKPWRVDDSE

ZNF691

46

Q5VV52
AGGHWPIEEEESSRG

ZFHX2

1571

Q9C0A1
WEVISDEHGIDPAGG

TUBB6

21

Q9BUF5
VLPWGALEEEEEDGG

TMC4

56

Q7Z404
DPNEVWEIVGELGDG

STK10

31

O94804
WEVISDEHGIDPSGN

TUBB3

21

Q13509
EGSWEDVLHLGEEAP

UNC5A

541

Q6ZN44
IQGWVREQHPGSGEE

ZNF213

101

O14771
EGPEPWGSTEHGVEV

SH2D3C

761

Q8N5H7
EPGQRGWQHEEGAEE

ZSCAN29

361

Q8IWY8
VGIGEHIWLGEIDEN

USP48

56

Q86UV5
HTWQQKRGPDEDGEE

TTYH3

411

Q9C0H2
DPVEWVEGNREGGTD

ZNF169

171

Q14929
GARHPSWEEEEDGGV

TNRC6B

1006

Q9UPQ9
GVESVPEEGILEAWG

nan

71

A6NHS1
GAVPIDDPEDGGKHW

LGMN

16

Q99538
DDPEDGGKHWVVIVA

LGMN

21

Q99538