Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentcell body fiber

SACS ASL

4.24e-0411592GO:0070852
GeneOntologyCellularComponentNSL complex

KANSL3 OGT

4.24e-0411592GO:0044545
HumanPhenoAreflexia of lower limbs

SACS VPS13A SCN9A GBE1 SPG11

3.75e-0593225HP:0002522
HumanPhenoDecreased number of peripheral myelinated nerve fibers

SACS VPS13A SCN9A SPG11

5.28e-0550224HP:0003380
HumanPhenoDecreased/absent ankle reflexes

SACS VPS13A SCN9A GBE1

6.65e-0553224HP:0200101
HumanPhenoPeripheral axonal neuropathy

TRAPPC11 VPS13A GBE1 SPG11 ATP11A STAT3

8.86e-05182226HP:0003477
DomainNa_channel_asu

SCN7A SCN9A

4.20e-0410582IPR001696
DomainNa_trans_assoc

SCN7A SCN9A

4.20e-0410582IPR010526
DomainNa_trans_assoc

SCN7A SCN9A

4.20e-0410582PF06512
DomainP_typ_ATPase_c

ATP11A ATP8B2

8.42e-0414582IPR032630
DomainP-type_ATPase_N

ATP11A ATP8B2

8.42e-0414582IPR032631
DomainP-type_ATPase_IV

ATP11A ATP8B2

8.42e-0414582IPR006539
DomainRas_G-nucl-exch_fac_CS

RGL1 RALGDS

8.42e-0414582IPR019804
DomainPhoLip_ATPase_C

ATP11A ATP8B2

8.42e-0414582PF16212
DomainPhoLip_ATPase_N

ATP11A ATP8B2

8.42e-0414582PF16209
DomainRasGEFN

RGL1 RALGDS

1.74e-0320582SM00229
DomainRasGEF_N

RGL1 RALGDS

1.92e-0321582PF00618
DomainRas-like_Gua-exchang_fac_N

RGL1 RALGDS

2.10e-0322582IPR000651
DomainRASGEF_NTER

RGL1 RALGDS

2.10e-0322582PS50212
DomainUbiquitin-rel_dom

RGL1 RALGDS SACS OASL

2.56e-03184584IPR029071
DomainRASGEF

RGL1 RALGDS

2.94e-0326582PS00720
DomainRASGEF_CAT

RGL1 RALGDS

3.65e-0329582PS50009
DomainRasGEF

RGL1 RALGDS

3.90e-0330582PF00617
Domain-

RGL1 RALGDS

3.90e-03305821.10.840.10
DomainRas_GEF_dom

RGL1 RALGDS

3.90e-0330582IPR023578
DomainRASGEF_cat_dom

RGL1 RALGDS

3.90e-0330582IPR001895
DomainRasGEF

RGL1 RALGDS

3.90e-0330582SM00147
DomainRA

RGL1 RALGDS

4.16e-0331582SM00314
Domain-

ATP11A ATP8B2

4.43e-03325823.40.1110.10
Domain-

ATP11A ATP8B2

4.43e-03325822.70.150.10
DomainATPase_P-typ_cyto_domN

ATP11A ATP8B2

5.28e-0335582IPR023299
DomainP_typ_ATPase

ATP11A ATP8B2

5.58e-0336582IPR001757
DomainRA

RGL1 RALGDS

5.58e-0336582PF00788
DomainATPase_P-typ_P_site

ATP11A ATP8B2

5.58e-0336582IPR018303
DomainATPASE_E1_E2

ATP11A ATP8B2

5.58e-0336582PS00154
DomainATPase_P-typ_transduc_dom_A

ATP11A ATP8B2

5.89e-0337582IPR008250
Pubmed

Interphase APC/C-Cdc20 inhibition by cyclin A2-Cdk2 ensures efficient mitotic entry.

ANAPC1 ANAPC4 CCNA2

2.58e-07859326960431
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

STARD13 NLRP7 PCDHGB5 SACS VPS13A SCN9A STRN4 XRN1 PDIA2 SPG11 ATP11A HMGCL NDUFS1

6.92e-071442591335575683
Pubmed

Regulation of the O-linked beta-N-acetylglucosamine transferase by insulin signaling.

OGT STAT3

2.83e-06259218519567
Pubmed

STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression.

MITF STAT3

2.83e-06259214737107
Pubmed

Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis.

ANAPC1 ANAPC4 CCNA2

3.10e-061759323160376
Pubmed

Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.

UBR5 ANAPC1 ANAPC4

3.10e-061759329033132
Pubmed

Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.

ANAPC1 ANAPC4 CCNA2

6.03e-062159318485873
Pubmed

RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein.

RGL1 RALGDS

8.48e-0635928710374
Pubmed

Identifying a common molecular mechanism for inhibition of MITF and STAT3 by PIAS3.

MITF STAT3

8.48e-06359216368885
Pubmed

Interplay between MITF, PIAS3, and STAT3 in mast cells and melanocytes.

MITF STAT3

8.48e-06359215572665
Pubmed

O-Linked N-acetylglucosamine transferase 1 regulates global histone H4 acetylation via stabilization of the nonspecific lethal protein NSL3.

KANSL3 OGT

8.48e-06359228450392
Pubmed

Evolution and diversity of mammalian sodium channel genes.

SCN7A SCN9A

1.69e-05459210198179
Pubmed

Neurotensin signaling regulates stem-like traits of glioblastoma stem cells through activation of IL-8/CXCR1/STAT3 pathway.

NTS STAT3

1.69e-05459225200966
Pubmed

Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane.

ATP11A ATP8B2

1.69e-05459225315773
Pubmed

STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway.

MITF STAT3

1.69e-05459233323974
Pubmed

O-GlcNAc-Modification of NSL3 at Thr755 Site Maintains the Holoenzyme Activity of MOF/NSL Histone Acetyltransfease Complex.

KANSL3 OGT

1.69e-05459231881804
Pubmed

Paradoxical mitotic exit induced by a small molecule inhibitor of APC/CCdc20.

ANAPC1 ANAPC4 CCNA2

2.44e-053359332152539
Pubmed

Ubiquitin chain elongation requires E3-dependent tracking of the emerging conjugate.

ANAPC1 ANAPC4 CCNA2

2.44e-053359325306918
Pubmed

Myeloid-derived cullin 3 promotes STAT3 phosphorylation by inhibiting OGT expression and protects against intestinal inflammation.

OGT STAT3

2.82e-05559228280036
Pubmed

The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression.

ANAPC1 ANAPC4

2.82e-05559219826416
Pubmed

Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation.

ANAPC1 ANAPC4 CCNA2

3.46e-053759326811472
Pubmed

Integrated RAS signaling defined by parallel NMR detection of effectors and regulators.

RGL1 RALGDS

4.23e-05659224441586
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

ANAPC1 DHCR24 LTN1 STRN4 NFS1 NDUFS1 STAT3

4.47e-0556059735241646
Pubmed

SUMO targets the APC/C to regulate transition from metaphase to anaphase.

ANAPC1 DHCR24 ANAPC4

4.72e-054159329549242
Pubmed

The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.

ANAPC1 ANAPC4

5.91e-05759227939943
Pubmed

Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.

OGT UBR5 DHCR24 LTN1 VPS13A CCNA2

6.70e-0540859633766124
Pubmed

Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.

ANAPC1 ANAPC4

7.87e-05859220686030
Pubmed

Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13.

STARD13 FRY

7.87e-0585928812419
Pubmed

Biochemical characterization of the Ras-related GTPases Rit and Rin.

RGL1 RALGDS

7.87e-05859210545207
Pubmed

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.

OGT SACS UBR5

8.59e-055059337974198
Pubmed

Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A.

ANAPC4 CCNA2

1.01e-04959218471975
Pubmed

Regulation of the anaphase-promoting complex by the COP9 signalosome.

ANAPC1 ANAPC4

1.01e-04959219535905
Pubmed

How APC/C-Cdc20 changes its substrate specificity in mitosis.

ANAPC4 CCNA2

1.01e-04959221336306
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

OGT UBR5 TMEM259 DHCR24 LTN1 VPS13A NDUFS1

1.21e-0465759736180527
Pubmed

Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons.

ANAPC1 ANAPC4

1.26e-041059210500174
Pubmed

The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators.

ANAPC4 CCNA2

1.26e-041059225669885
Pubmed

Crosstalk between NSL histone acetyltransferase and MLL/SET complexes: NSL complex functions in promoting histone H3K4 di-methylation activity by MLL/SET complexes.

KANSL3 OGT

1.26e-041059224244196
Pubmed

Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex.

ANAPC1 ANAPC4

1.26e-041059210318877
Pubmed

Intersubspecific subcongenic mouse strain analysis reveals closely linked QTLs with opposite effects on body weight.

SCN7A SCN9A

1.26e-041059221451961
Pubmed

Stable MCC binding to the APC/C is required for a functional spindle assembly checkpoint.

ANAPC1 ANAPC4

1.26e-041059224464857
Pubmed

SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.

ANAPC1 ANAPC4

1.26e-041059222014574
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

BHLHE23 UBR5 TMEM259 DHCR24 LTN1 OASL GBE1 NDUFS1 STAT3 CCNA2

1.42e-041440591030833792
Pubmed

The PP2AB56 phosphatase promotes the association of Cdc20 with APC/C in mitosis.

ANAPC1 ANAPC4

1.54e-041159228404789
Pubmed

Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner.

ANAPC4 CCNA2

1.54e-041159221241890
Pubmed

Mitotic regulation of the human anaphase-promoting complex by phosphorylation.

ANAPC1 ANAPC4

1.85e-041259214657031
Pubmed

Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex.

KANSL3 OGT

1.85e-041259220018852
Pubmed

Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation.

ANAPC4 CCNA2

1.85e-041259223007648
Pubmed

Conformation-specific anti-Mad2 monoclonal antibodies for the dissection of checkpoint signaling.

ANAPC1 ANAPC4

1.85e-041259226986935
Pubmed

Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.

ANAPC1 ANAPC4

1.85e-041259216364912
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

RGL1 SACS LTN1 ATP11A ATP8B2 RIC1

1.88e-0449359615368895
Pubmed

The DNA sequence and analysis of human chromosome 13.

STARD13 FRY SACS ATP11A

2.03e-0417059415057823
Pubmed

Gene expression and cell identity controlled by anaphase-promoting complex.

ANAPC1 ANAPC4 CCNA2

2.15e-046859332076268
Pubmed

The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20.

ANAPC1 ANAPC4

2.18e-041359223979597
Pubmed

Differential expression of putative transbilayer amphipath transporters.

ATP11A ATP8B2

2.18e-041359211015572
Pubmed

MOF-associated complexes ensure stem cell identity and Xist repression.

KANSL3 OGT

2.18e-041359224842875
Pubmed

Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.

ANAPC1 ANAPC4

2.18e-041359216921029
Pubmed

HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.

RNF146 STRN4

2.18e-041359223277359
Pubmed

MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C.

ANAPC4 CCNA2

2.18e-041359225750436
Pubmed

Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression.

ANAPC1 CCNA2

2.54e-041459219826003
Pubmed

Characterization of vertebrate cohesin complexes and their regulation in prophase.

ANAPC1 ANAPC4

2.54e-041459211076961
Pubmed

The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex.

ANAPC1 ANAPC4

2.93e-041559210922056
Pubmed

APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.

ANAPC1 ANAPC4

2.93e-041559223007861
Pubmed

Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex.

ANAPC1 ANAPC4

3.34e-041659210548110
Pubmed

The anaphase-promoting complex: a key factor in the regulation of cell cycle.

ANAPC1 ANAPC4

3.34e-041659215678131
Pubmed

Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.

ANAPC1 ANAPC4

3.34e-041659225306923
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

OGT CENPN UBR5 ANAPC1 INPP4A XRN1 SPG11 NDUFS1 CCNA2

3.76e-04132759932694731
Pubmed

Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.

ANAPC1 ANAPC4

3.79e-041759212070128
Pubmed

A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression.

ANAPC1 ANAPC4

3.79e-041759211340163
Pubmed

TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.

ANAPC1 ANAPC4

3.79e-041759212956947
Pubmed

Atomic structure of the APC/C and its mechanism of protein ubiquitination.

ANAPC1 ANAPC4

3.79e-041759226083744
Pubmed

Lesson from the stoichiometry determination of the cohesin complex: a short protease mediated elution increases the recovery from cross-linked antibody-conjugated beads.

ANAPC1 ANAPC4

3.79e-041759221043528
Pubmed

Mechanism of APC/CCDC20 activation by mitotic phosphorylation.

ANAPC1 ANAPC4

3.79e-041759227114510
Pubmed

Recombinant expression, reconstitution and structure of human anaphase-promoting complex (APC/C).

ANAPC1 ANAPC4

3.79e-041759223078409
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

DHCR24 CD38 NTS LTN1 VPS13A SPG11 ATP8B2 ADGRA3

4.08e-04106159833845483
Pubmed

BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner.

ANAPC1 ANAPC4

4.25e-041859222193957
Pubmed

The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.

OASL STAT3

4.25e-041859227001747
Pubmed

Mitotic regulation of the APC activator proteins CDC20 and CDH1.

ANAPC1 ANAPC4

4.25e-041859210793135
Pubmed

The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit.

ANAPC1 ANAPC4

4.25e-041859214593737
Pubmed

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2.

ANAPC1 ANAPC4

4.25e-041859211535616
Pubmed

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.

ANAPC1 LTN1 STRN4 XRN1

4.70e-0421259433853758
Pubmed

Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation.

STAT3 CCNA2

4.75e-041959228067668
Pubmed

Molecular mechanism of APC/C activation by mitotic phosphorylation.

ANAPC1 ANAPC4

4.75e-041959227120157
Pubmed

Molecular architecture and mechanism of the anaphase-promoting complex.

ANAPC1 ANAPC4

4.75e-041959225043029
Pubmed

Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.

ANAPC1 ANAPC4

4.75e-041959225490258
Pubmed

APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box.

ANAPC1 ANAPC4

5.27e-042059211742988
Pubmed

Loss of Shp2-mediated mitogen-activated protein kinase signaling in Muller glial cells results in retinal degeneration.

MITF STAT3

5.82e-042159221576358
Pubmed

Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.

OGT UBR5 EXOSC6 STRN4 STAT3

5.84e-0439959537536630
Pubmed

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.

RALGDS XRN1 PLEK CCNA2

6.07e-0422759426410627
Pubmed

Proximity Labeling Reveals Spatial Regulation of the Anaphase-Promoting Complex/Cyclosome by a Microtubule Adaptor.

ANAPC4 CCNA2

6.39e-042259235952650
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

OGT UBR5 ANAPC1 INPP4A XRN1

7.19e-0441859534709266
Pubmed

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.

FRY UBR5 EXOSC6 STRN4 ANAPC4 CCNA2

7.41e-0463959623443559
Pubmed

A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models.

ANAPC1 ANAPC4

7.62e-042459233705438
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

ANAPC1 LTN1 XRN1 NDUFS1

7.71e-0424259434011540
Pubmed

CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.

OGT UBR5 NDUFS1

8.34e-0410859330166453
Pubmed

APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain.

ANAPC1 ANAPC4

9.66e-042759234942119
Pubmed

Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest.

UBR5 STAT3

9.66e-042759221320693
Pubmed

E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs.

OGT XRN1

1.04e-032859230277474
Pubmed

Gene expression and dental enamel structure in developing mouse incisor.

STAT3 CCNA2

1.12e-032959220487000
Pubmed

Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.

PLEK STAT3

1.12e-032959222190364
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

STARD13 MROH9 DENND1B DHCR24 VPS13A GBE1 ATP11A ATP8B2

1.14e-03124259830973865
InteractionB3GALT2 interactions

TMEM259 LTN1 ADGRA3

7.64e-0614573int:B3GALT2
CytobandEnsembl 112 genes in cytogenetic band chr13q13

STARD13 FRY NBEA

1.66e-0482593chr13q13
Cytoband4p15.2

ADGRA3 ANAPC4

6.01e-04285924p15.2
CytobandEnsembl 112 genes in cytogenetic band chr4p15

CD38 ADGRA3 ANAPC4

7.17e-04135593chr4p15
GeneFamilyAnaphase promoting complex |Tetratricopeptide repeat domain containing

ANAPC1 ANAPC4

4.49e-0414412402
GeneFamilyATPase phospholipid transporting

ATP11A ATP8B2

5.17e-04154121210
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

STARD13 RGL1 OGT SACS UBR5 LTN1 MITF VPS13A GBE1 SPG11 SLC16A7 ADGRA3

3.72e-078565912M4500
CoexpressionGSE1460_INTRATHYMIC_T_PROGENITOR_VS_DP_THYMOCYTE_DN

SLC6A7 FRY ASL CD38 MITF STAG3

5.40e-06197596M3438
CoexpressionNICK_RESPONSE_TO_PROC_TREATMENT_DN

UBR5 TMEM259 SPG11

3.05e-0527593M8801
CoexpressionGSE7768_OVA_ALONE_VS_OVA_WITH_LPS_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_DN

RGL1 RALGDS CD38 MITF PLEK

4.08e-05170595M6852
CoexpressionGSE11864_CSF1_PAM3CYS_VS_CSF1_IFNG_PAM3CYS_IN_MAC_DN

DENND1B CENPN INPP4A MITF OASL

7.45e-05193595M3149
CoexpressionGSE35543_IN_VIVO_NTREG_VS_IN_VITRO_ITREG_UP

MROH9 PEMT SCN7A ADAM2 STAG3

8.61e-05199595M9430
CoexpressionGSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_DN

SLC6A7 RGL1 FRY MAN1C1 ATP11A

8.61e-05199595M3445
CoexpressionGSE11961_MARGINAL_ZONE_BCELL_VS_GERMINAL_CENTER_BCELL_DAY40_UP

FRY SACS ANAPC1 CD38 ATP8B2

8.82e-05200595M9317
CoexpressionGSE35825_IFNA_VS_IFNG_STIM_MACROPHAGE_DN

FRY OGT DENND1B INPP4A ATP8B2

8.82e-05200595M8656
CoexpressionGSE3982_MAST_CELL_VS_BCELL_UP

DENND1B RNF146 DHCR24 COL14A1 ADGRA3

8.82e-05200595M5434
CoexpressionGSE37301_RAG2_KO_VS_RAG2_AND_ETS1_KO_NK_CELL_UP

DHCR24 COL14A1 ATP11A ADGRA3 ANAPC4

8.82e-05200595M8844
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

RALGDS OGT DENND1B SACS UBR5 MAN1C1 INPP4A XRN1 SPG11 SLC16A7 ATP8B2 STAT3

1.02e-0414925912M40023
CoexpressionQUEREC_PBMC_YF_17D_VACCINE_AGE_18_45YO_7DY_UP

RGL1 CD38 OASL

1.54e-0446593M41048
CoexpressionQUEREC_PBMC_YF_17D_VACCINE_AGE_18_45YO_3DY_UP

RGL1 CD38 OASL

1.54e-0446593M41047
ToppCellNS-critical-d_07-13-Myeloid-Monocyte-derived_Macrophage|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

RGL1 ABHD16B CD38 OASL XRN1 PLEK

2.15e-071935960dd83b21e164147abfd511a927615c40a28781a2
ToppCell5'-Adult-Distal_Rectal-Hematopoietic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RGL1 SCN9A NBEA PLEK SLC16A7

3.36e-06173595b335ca2a247156eba821943b2b9fc9922230b409
ToppCellnucseq-Immune-Lymphocytic_B-Lymphocytic_B-Plasma|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

OGT DENND1B CD38 XRN1 RIC1

4.66e-061855953b77bc49cd3740acc025e162a36282ac09e12198
ToppCellcritical-Myeloid-Monocyte-derived_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

RGL1 DENND1B CD38 OASL XRN1

4.91e-0618759572e4aec49ea0c5fe6cee2a1a46369dbc90cd3fad
ToppCell5'-Adult-Distal_Rectal-Hematopoietic-Myeloid-LYVE1+_Macrophage|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RGL1 TRAPPC11 MAN1C1 SCN9A SLC16A7

5.17e-061895959e3c083174a64ea78648c6d48498fc4e721b569f
ToppCell5'-Adult-Distal_Rectal-Hematopoietic-Myeloid|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RGL1 TRAPPC11 MAN1C1 SCN9A SLC16A7

5.17e-061895956e19bfa52406ebe095daa99f958ec4d596ce6e39
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Sema3e_Kank4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MAN1C1 MITF SCN9A ADGRA3

3.10e-0513559454b2aaf8d322e01a3ff6099c2422d68ecccf96b4
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Itm2a|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MAN1C1 MITF SCN9A ADGRA3

3.99e-051445940bbe670454846cf9bc7464ae4e91488415c4111d
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

DENND1B COL14A1 CCDC65 ADGRA3

3.99e-051445945e948d4cb913ccd8f82262a1b4d20967aadab3ab
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MAN1C1 MITF SCN9A ADGRA3

6.47e-05163594db6b7ce6f7221bb73c5e650ac51cdd5d7ef00675
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Pleural_Mac|Myeloid_cells / Location, Cell class and cell subclass

RGL1 CD38 NTS ADAM2

6.63e-05164594362c16ed7fb37bf16601fd5e059d3f3e2ed692b4
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Tac1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MAN1C1 MITF SCN9A ADGRA3

6.78e-05165594d8df50f5a3b646e8ea13739fdc65ce6f39b4d4d2
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Tpbg|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MAN1C1 MITF SCN9A ADGRA3

6.94e-05166594b4241f8d2a0aa910dbb0d0d5d3631a9b73453fe9
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MAN1C1 MITF SCN9A ADGRA3

7.27e-051685942572a3dd4f3f619bd26a3cd6e60de43821d8bb64
ToppCell10x3'2.3-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FRY DENND1B DHCR24 MITF

7.97e-051725943a76cfb2832790144a6da6406469ead0767916b5
ToppCell10x3'2.3-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FRY SCN7A PLEK CCDC65

8.15e-051735941e4afa020fae682521335b440ccd33c16f37156f
ToppCell390C-Lymphocytic-CD4_T-cell-Proliferating_T_cell|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

CENPN CD38 ADGRA3 CCNA2

8.71e-05176594941e8724b6f680719ef2a4f190f943b205bb9e78
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NLRP7 INPP4A SCN9A PLEK

9.29e-051795944808469096cd6bec2bdfcf4fc55aa324757600c3
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NLRP7 INPP4A SCN9A PLEK

9.29e-051795944d55718c6afd8a038d93cc77b9b08171dab9976f
ToppCell5'-Adult-SmallIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

OGT CD38 PLEK RIC1

9.91e-05182594626aabfd9ac662c1d189f7c4b660482914d9e669
ToppCell5'-Adult-SmallIntestine-Hematopoietic-Plasma_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

OGT CD38 PLEK RIC1

9.91e-05182594a00abff41c12b71d5860c494b8c722d649fd5f36
ToppCellCV-Healthy-7|CV / Virus stimulation, Condition and Cluster

DENND1B DHCR24 ATP11A NDUFS1

1.03e-041845940e5cc77aaa73ceb791f8be7456177577fd2e5586
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

RGL1 SCN7A COL14A1 STAT3

1.03e-0418459467164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L3-4_RORB_RPS3P6|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC6A7 SCN7A SCN9A COL14A1

1.06e-0418559410da5c2a92bfb3248d3f6f94a0933996326cf590
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Pleural_Mac|metastatic_Lymph_Node / Location, Cell class and cell subclass

RGL1 CD38 ADAM2 PLEK

1.10e-0418759488fac9f23047892acccbcc355d02ff079596fedf
ToppCell-Unknown-Endothelial-Myofibroblast| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RGL1 PCDHGB5 UBR5 XRN1

1.12e-041885946468fa95ad0395395301115286f2d8c0df5d3882
ToppCell-Unknown-Endothelial| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RGL1 PCDHGB5 UBR5 XRN1

1.12e-041885947a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell-Unknown| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RGL1 PCDHGB5 UBR5 XRN1

1.12e-041885949cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCellCOVID-19-Heart-Macrophage|COVID-19 / Disease (COVID-19 only), tissue and cell type

STARD13 RGL1 SCN9A PLEK

1.15e-041895942586f4088721c5debec86c2b211b739fd33713eb
ToppCellControl-Plasmablast|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

NLRP7 INPP4A CD38 ATP8B2

1.19e-041915943df5bbdb29bbcbcb8476fdf126b6d4c1ac67d64b
ToppCellCOVID-19-Myeloid-MoAM1,_IL1R2|Myeloid / Condition, Lineage and Cell class

RGL1 CD38 OASL XRN1

1.22e-04192594be9d5685fa03563322f147a4b38ed31e4da59487
ToppCellBAL-Mild|BAL / Compartment, Disease Groups and Clusters

CD38 OASL XRN1 RBM43

1.22e-041925941a6cbf014d3f7a3fb6f53adab078c4742e7137de
ToppCellCV-Healthy-6|CV / Virus stimulation, Condition and Cluster

RALGDS CD38 OASL PLEK

1.24e-041935941e285c31823d3e1a18d8c01748cc3604f400c954
ToppCellmoderate-Myeloid-Monocyte-derived_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

RGL1 CD38 OASL XRN1

1.24e-0419359422455801194bd8c73c5c397f5eac4f723429c383
ToppCellCD8+_Memory_T_cell-CV-6|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

RALGDS CD38 OASL PLEK

1.27e-0419459435a347c3824757b9de8b7f49db46e73e7fb63a4f
ToppCellcritical-Myeloid-Monocyte-derived_Macrophage|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

RGL1 CD38 OASL XRN1

1.27e-04194594e36d1fd141bdcbd9ed66a33de6cdfde77189a0c1
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

STARD13 RGL1 MITF PLEK

1.27e-0419459445708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCellmoderate-Myeloid-Monocyte-derived_Macrophage|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

RGL1 CD38 OASL PLEK

1.29e-041955949c9634906168239cf978adb398787692437bf9e7
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RGL1 DENND1B CD38 PLEK

1.29e-041955942f2e29089a8cb748d2c1329c5c8465165b25bc8b
ToppCellNS-moderate-d_16-33-Myeloid-Monocyte-derived_Macrophage|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

RGL1 CD38 OASL PLEK

1.29e-04195594d87c83d2d421c9291d0a10bc9db850e9fb337667
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RGL1 DENND1B CD38 PLEK

1.29e-04195594c9469e2d31beb30ebb64b3f0a5239e23119fbaa5
ToppCellCV-Moderate-1|Moderate / Virus stimulation, Condition and Cluster

CD38 OASL XRN1 PLEK

1.32e-04196594b50cfcd87c5b67806450cb8b3c6860ab97f6d3b1
ToppCellCV-Moderate-1|CV / Virus stimulation, Condition and Cluster

CD38 OASL XRN1 PLEK

1.34e-04197594e3d00d850b4d191f9592ef993c0eaadfe5710b5f
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

OGT VPS13A XRN1 STAT3

1.34e-0419759457ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCellControl-Control-Lymphocyte-T/NK-NK_activated|Control / Disease, condition lineage and cell class

INPP4A CD38 OASL PLEK

1.37e-0419859476d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCellSigmoid-B_cell-B_cell_IgG_Plasma|B_cell / Region, Cell class and subclass

MAN1C1 CD38 XRN1 SLC16A7

1.37e-04198594305d7ae9b070ac7211638a5282374c02bf13af40
ToppCellCV|World / Virus stimulation, Condition and Cluster

RALGDS CD38 OASL PLEK

1.37e-041985946a28193af35abec5c029129930c2ca6febaafde2
ToppCellCD8+_Memory_T_cell-CV|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

RALGDS CD38 OASL PLEK

1.37e-041985943d1749f5106f0912f4a74615863853949f52c73d
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-Prolif_T-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CENPN CD38 OASL CCNA2

1.40e-0419959475f221c99adaa29f45dbe365f638b8b123eea148
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-Prolif_T|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CENPN CD38 OASL CCNA2

1.40e-04199594ef767641b669eb2ef3461e51548f4dd09292de90
ToppCellsevere_influenza-T/NK_proliferative|World / disease group, cell group and cell class (v2)

CENPN DHCR24 CD38 CCNA2

1.40e-041995941541f655f7d12c650added3683d07e5417a68dfb
ToppCellTracheal-10x3prime_v2-Stromal-Schwann-Schwann_nonmyelinating|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

STARD13 SCN7A SCN9A XRN1

1.40e-04199594a92718a3f1153b8d2196fd343ed5bc0ebc98cad7
ToppCellTracheal-10x3prime_v2-Stromal-Schwann|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

STARD13 SCN7A SCN9A XRN1

1.40e-041995948dc65662c3ca1db2ba0091332f0658abc0afc5de
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CENPN CD38 OASL CCNA2

1.42e-04200594562309f9ca4a73cea5ed1d85b516891545f3ae5f
DiseaseIntellectual Disability

RALGDS FRY SACS INPP4A NBEA HMGCL CCNA2

2.70e-05447587C3714756
DiseaseInherited neuropathies

SACS SCN9A SPG11

6.76e-0540583C0598589
DiseaseMental Retardation, Psychosocial

RALGDS FRY INPP4A CCNA2

1.64e-04139584C0025363
DiseaseProfound Mental Retardation

RALGDS FRY INPP4A CCNA2

1.64e-04139584C0020796
DiseaseMental deficiency

RALGDS FRY INPP4A CCNA2

1.64e-04139584C0917816
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN7A SCN9A

1.69e-0410582DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN7A SCN9A

1.69e-0410582DOID:0080422 (implicated_via_orthology)
Diseaseamino acid metabolic disorder (is_implicated_in)

ASL HMGCL

2.06e-0411582DOID:9252 (is_implicated_in)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN7A SCN9A

2.47e-0412582DOID:0060170 (implicated_via_orthology)
DiseaseUsual Interstitial Pneumonia

ATP11A STAT3

6.36e-0419582C4721509
DiseaseHamman-Rich Disease

ATP11A STAT3

6.36e-0419582C4721508
DiseaseFamilial Idiopathic Pulmonary Fibrosis

ATP11A STAT3

7.05e-0420582C4721952
DiseaseIdiopathic Pulmonary Fibrosis

ATP11A STAT3

7.78e-0421582C1800706
Diseaseobsolete_red blood cell distribution width

RALGDS OGT DENND1B TMEM259 RNF146 VPS13A ATP11A PLEK CCNA2

1.19e-031347589EFO_0005192
Diseasecolon adenocarcinoma (is_implicated_in)

UBR5 STAT3

1.20e-0326582DOID:234 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
SESLLYHLSELKGMA

ANAPC4

356

Q9UJX5
LAQLLSLSMGITYDD

ADAM2

311

Q99965
MAELKSLSGDAYLAL

BHLHE23

1

Q8NDY6
AVLMDLTGSELYTQA

ADGRA3

741

Q8IWK6
SLLEESYNMELEALT

CCDC65

136

Q8IXS2
ATMTYPELGALVLDA

ABHD16B

256

Q9H3Z7
EMGTAITYQLLAILD

ATP8B2

541

P98198
DMFTLEDTLLGYLAD

CD38

141

P28907
LAVAEGLLLTSMAYD

OR2L2

106

Q8NH16
SGEMLVLDTDVFLYL

RBM43

216

Q6ZSC3
DLTMLDTALQDYIEG

RGL1

426

Q9NZL6
LMAQDLDTAASYLII

RIC1

931

Q4ADV7
ESLLSTYGEELAMLE

INPP4A

716

Q96PE3
DLLNTLLESEDSYLM

LTN1

926

O94822
DTMLVLEGSGNLVLY

ANAPC1

486

Q9H1A4
LSFAYVEGESLLMAL

NFS1

356

Q9Y697
ALALADAGVEMYDLV

EXOSC6

166

Q5RKV6
GQALSPDMLATDLAY

ASL

361

P04424
GIDEYSAAFLLSVMA

SLC16A7

276

O60669
LALAQDALDMTFGLT

PDIA2

191

Q13087
SIMASDLEPLALASY

PCDHGB5

486

Q9Y5G0
DLEPLALASYVSMSA

PCDHGB5

491

Q9Y5G0
LLDAYSGLLSNESMI

MROH9

31

Q5TGP6
LDEGFTTVMDLLLEY

OASL

256

Q15646
MESLDTPAAYSLGLA

PEMT

81

Q9UBM1
TALDGFSLEAMLTIY

NTS

91

P30990
FGLQVDEDALTYLML

GBE1

381

Q04446
LALPMASDLLLYDVT

COL14A1

441

Q05707
FVEGLLYSLDEAVIM

DHCR24

266

Q15392
ASISDAALLDIIYMQ

CENPN

61

Q96H22
YLGTFLTDLVMLDTA

RALGDS

566

Q12967
SGATVIDSLDTLYLM

MAN1C1

216

Q9NR34
LDEFLGYDDILMSSV

TMEM259

256

Q4ZIN3
ETLSLPMLAAYLDAL

KANSL3

201

Q9P2N6
GYVMEALLTLEAAVD

FRY

1906

Q5TBA9
ELVASLEDASLMGLY

C1orf127

46

Q8N9H9
SLAMFLGELSLIDAD

CCNA2

331

P20248
YSGEMDLLGEILDTL

DENND1B

561

Q6P3S1
DNLISDTSYLIAMLG

SACS

4111

Q9NZJ4
YINLAAALVAAGDME

OGT

126

O15294
GMYLEDLDVLAGTAL

STARD13

361

Q9Y3M8
LSEIAGMTLPYDTLD

NDUFS1

626

P28331
EGLMIASSLLNEGYL

PLEK

176

P08567
LATEDLVYMLEGLGI

HMGCL

276

P35914
DLLVDMLGVLASYSI

NBEA

176

Q8NFP9
MILLSSGALAFEDIY

SCN9A

1201

Q15858
TEMLIAGFLYVADLE

RNF146

136

Q9NTX7
LSANVLLDEGAMLLY

NLRP7

796

Q8WX94
VLLDDYSASFGLMVV

SLC6A7

451

Q99884
LSGLSADMQDYGLII

ATP11A

746

P98196
LKALTLMLDAAESYA

SPG11

2266

Q96JI7
DLGFIYALTDLMTEA

VPS13A

2716

Q96RL7
YADIPFLLMTDLLSA

TRAPPC11

906

Q7Z392
ISLESSYNEEILGLM

MITF

231

O75030
LLYGVLEMDAASDVF

STAG3

881

Q9UJ98
SIVSELAGLLSAMEY

STAT3

216

P40763
CLYGLDADLIMLGLT

XRN1

201

Q8IZH2
ASLFLGILAMAYEEE

SCN7A

386

Q01118
VLYDMEVGSALLTLE

STRN4

616

Q9NRL3
LLADILMAQGSYEEA

TTC34

311

A8MYJ7
SYLPGEDLMSLLDAD

UBR5

241

O95071