Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domainzf-C2H2

ZNF729 PRDM10 SLC2A4RG ZNF268 ZNF366 ZNF786 ZNF335

1.25e-03693457PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF729 PRDM10 SLC2A4RG ZNF268 ZNF366 ZNF786 ZNF335

1.26e-03694457IPR013087
DomainATPase_AAA_CS

PSMC5 NSF

2.21e-0329452IPR003960
DomainZINC_FINGER_C2H2_2

ZNF729 PRDM10 SLC2A4RG ZNF268 ZNF366 ZNF786 ZNF335

2.36e-03775457PS50157
DomainZINC_FINGER_C2H2_1

ZNF729 PRDM10 SLC2A4RG ZNF268 ZNF366 ZNF786 ZNF335

2.40e-03777457PS00028
DomainZnf_C2H2-like

ZNF729 PRDM10 SLC2A4RG ZNF268 ZNF366 ZNF786 ZNF335

2.74e-03796457IPR015880
DomainZnf_C2H2

ZNF729 PRDM10 SLC2A4RG ZNF268 ZNF366 ZNF786 ZNF335

2.92e-03805457IPR007087
DomainZnF_C2H2

ZNF729 PRDM10 SLC2A4RG ZNF268 ZNF366 ZNF786 ZNF335

2.98e-03808457SM00355
DomainAAA

PSMC5 NSF

3.03e-0334452PS00674
Domain-

ZNF729 PRDM10 ZNF268 ZNF366 ZNF786 ZNF335

5.50e-036794563.30.160.60
DomainSET_dom

SETD1A PRDM10

6.46e-0350452IPR001214
DomainSET

SETD1A PRDM10

6.46e-0350452PS50280
DomainAAA

PSMC5 NSF

6.97e-0352452PF00004
DomainATPase_AAA_core

PSMC5 NSF

7.50e-0354452IPR003959
Pubmed

Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia.

DOCK4 CNTNAP5

1.79e-06247220346443
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

PSMC5 SETD1A MCM5 CAD UTRN SVIL

3.99e-0631347638270169
Pubmed

CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.

CUL2 PSMC5 SETD1A MCM5 CAD PDE12 NSF

4.30e-0649447726831064
Pubmed

Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.

CUL2 PSMC5 MCM5 CAD ANKFY1 NSF PPM1B

4.36e-0649547728581483
Pubmed

Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.

DOCK4 PSMC5 MCM5 CAD NSF PPM1B

1.26e-0538347629331416
Pubmed

Quantitative interactome proteomics identifies a proteostasis network for GABAA receptors.

PSMC5 CAD LRCH2 SVIL

2.52e-0512547436030824
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

PSMC5 MCM5 CAD EIF3C NSF PPM1B SVIL

2.79e-0566047732780723
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

CUL2 PSMC5 MCM5 EIF3C ANKFY1 PDE12 NSF UTRN

5.47e-05100547819615732
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

PSMC5 UTP20 MCM5 CAD EIF3C NSF UTRN SVIL

6.24e-05102447824711643
Pubmed

Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression.

CUL2 CAD

6.40e-05947228775317
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

MCM5 CAD ANKFY1 ZGRF1 AGTPBP1 PPM1B

6.43e-0551347625798074
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

CUL2 UTP20 FASTKD5 EIF3C LRCH2 NSF DNAJC19

6.48e-0575447733060197
Pubmed

Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.

FASTKD5 PDE12 PRORP LRCH2 UTRN DNAJC19

6.57e-0551547631617661
Pubmed

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

PSMC5 CAD EIF3C ANKFY1 PPM1B

7.14e-0532047528685749
Pubmed

Human ALKBH4 interacts with proteins associated with transcription.

MLLT3 EIF3C

7.99e-051047223145062
Pubmed

Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.

PSMC5 MCM5 CAD EIF3C ANKFY1 PPM1B

9.52e-0555147634728620
Pubmed

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.

PSMC5 MCM5 CAD EIF3C ANKFY1 PPM1B

1.02e-0455847627591049
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

PSMC5 UTP20 FASTKD5 MCM5 CAD EIF3C ANKFY1 PDE12 NSF

1.06e-04142547930948266
Pubmed

KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise.

CUL2 SVIL

1.86e-041547218984674
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

PSMC5 MCM5 CAD EIF3C ANKFY1 NSF

2.11e-0463847633239621
Pubmed

Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions.

MAPK12 PPM1B

2.12e-041647219294699
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

SETD1A UTP20 MCM5 EIF3C UTRN

2.27e-0441047526949251
Pubmed

Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner.

CAD ANKFY1 PPM1B SVIL

2.32e-0422247435941108
Pubmed

GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.

MCM5 CAD PPM1B SVIL

2.36e-0422347433731348
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

HMBOX1 PSMC5 MLLT3 MCM5 CAD NSF PPM1B SVIL

2.42e-04124747827684187
Pubmed

Network organization of the human autophagy system.

CUL2 PSMC5 ANKFY1 NSF UTRN

3.04e-0443747520562859
Pubmed

Variability in Streptavidin-Sepharose Matrix Quality Can Significantly Affect Proximity-Dependent Biotinylation (BioID) Data.

FASTKD5 MCM5 PDE12 PRORP DNAJC19

3.07e-0443847532628020
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

CUL2 PSMC5 MCM5 EIF3C PRORP NSF UTRN

3.13e-0497447728675297
Pubmed

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.

ZNF729 CUL2 MCM5 CAD EIF3C

3.51e-0445147536168627
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

PSMC5 UTP20 MCM5 CAD EIF3C PDE12

3.57e-0470447629955894
Pubmed

The key features of SARS-CoV-2 leader and NSP1 required for viral escape of NSP1-mediated repression.

EIF3C PDE12

3.69e-042147235232816
Pubmed

BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.

PSMC5 SETD1A FASTKD5 EIF3C PDE12 UTRN

3.76e-0471147633022573
Pubmed

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.

DOCK4 MCM5 CAD SVIL

3.93e-0425547415324660
Pubmed

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.

PPP1R21 PSMC5 MCM5 CAD PDE12

3.96e-0446347527503909
Pubmed

Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.

PSMC5 CAD EIF3C NSF

3.99e-0425647435777956
Pubmed

Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.

MCM5 CAD ANKFY1 PPM1B

3.99e-0425647432698014
Pubmed

Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.

PSMC5 MCM5 CAD EIF3C

4.11e-0425847421081666
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

PSMC5 SETD1A UTP20 MCM5 CAD ANKFY1 PDE12 UTRN

4.18e-04135347829467282
Pubmed

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.

PSMC5 UTP20 ANKFY1 NSF

4.35e-0426247436880596
Pubmed

Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network.

CUL2 FASTKD5 CAD

4.63e-0411147332683582
Pubmed

An Interaction Landscape of Ubiquitin Signaling.

CUL2 PSMC5 PDE12 AGTPBP1 PPM1B

4.71e-0448147528190767
Pubmed

Ubiquilin 2 modulates ALS/FTD-linked FUS-RNA complex dynamics and stress granule formation.

PSMC5 MCM5 NSF PPM1B

4.81e-0426947430442662
Pubmed

Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes.

CUL2 MCM5

4.84e-042447234195792
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

PSMC5 CAD EIF3C UTRN AGTPBP1 PPM1B SVIL

4.88e-04104947727880917
Pubmed

Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.

MCM5 AGTPBP1

5.26e-042547215385968
Pubmed

VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma.

PSMC5 MCM5 CAD

6.10e-0412247336929488
Pubmed

The full-ORF clone resource of the German cDNA Consortium.

ZNF729 ZGRF1

6.61e-042847217974005
Pubmed

The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.

UTP20 MCM5 CAD NSF

7.05e-0429847430737378
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

MCM5 CAD EIF3C ANKFY1 LRCH2

7.55e-0453447535032548
Pubmed

Proteomic analysis of the NOS2 interactome in human airway epithelial cells.

PSMC5 CAD PPM1B

8.72e-0413847323438482
Pubmed

Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.

FASTKD5 EIF3C PPM1B

8.91e-0413947325476789
Pubmed

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.

PSMC5 MCM5 EIF3C UTRN DNAJC19 ZGRF1

9.40e-0484747635235311
Pubmed

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.

PSMC5 MCM5 CAD ANKFY1 LRCH2

1.02e-0357147537167062
Pubmed

Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN.

PSMC5 EIF3C LRCH2 SVIL

1.08e-0333447430425250
Pubmed

SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.

MCM5 EIF3C ANKFY1 PDE12 NSF

1.33e-0360747539147351
Pubmed

The von Hippel-Lindau Cullin-RING E3 ubiquitin ligase regulates APOBEC3 cytidine deaminases.

PSMC5 ANKFY1

1.35e-034047234004371
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF729 PRDM10 ZNF268 ZNF366 ZNF786 ZNF335

5.56e-0471827628
GeneFamilyAAA ATPases

PSMC5 NSF

2.82e-0353272413
ToppCelldroplet-Lung-1m-Hematologic-myeloid-Basophil/Mast_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PRDM10 CAD TNFAIP8 MAPK12

3.04e-05173464117163c5cd2b7aaa1c0682c8ac44b4249df4d2f8
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCM5 LDLRAD3 NSF SVIL

3.04e-05173464c31076c725f4cd912c56903592a2d9356ae59f54
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCM5 LDLRAD3 NSF SVIL

3.04e-05173464a4ed191cfdf6588b7f3672995bf0a4fe9e4b8df6
ToppCelldroplet-Lung-1m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PRDM10 CAD TNFAIP8 MAPK12

3.04e-0517346401df9baeedf30e3a4891738554cdd300394dbb96
ToppCell3'-Adult-LargeIntestine-Hematopoietic-Myeloid-cDC1|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CARD11 TNFAIP8 LDLRAD3 ZNF366

4.03e-051864645916ee851c17d6d9adefeea900b4dfa9642982dc
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_3|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

SETD1A EIF3C NSF PPM1B

4.29e-0518946499b01893da9f9f7c9528afaffad178285211738b
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Lymphocytic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

PSMC5 SETD1A MCM5 UTRN

4.38e-05190464373629dde5eda722424c5e6087763f0c5db67cf4
ToppCellCOVID-19-Heart-T_cell|Heart / Disease (COVID-19 only), tissue and cell type

CARD11 ALAS2 CNTNAP5 TNFAIP8

4.38e-05190464e6c3a6e01fef6c5b49f72661d4fb0414ba9046bf
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B1|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

CUL2 UTP20 FASTKD5 ANKFY1

4.38e-051904642434b8ad2976eab7d9147012c28454ab29670709
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CUL2 UTP20 FASTKD5 ANKFY1

4.47e-0519146439ef8e1d7cc3ebb11717e8a55501515e3b72b177
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 LDLRAD3 UTRN ZNF366

4.56e-051924641ee4783051ec94ea94600f040edcb385fc4289f1
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MLLT3 MCM5 ANKFY1 ZGRF1

4.75e-05194464af4bbb2deb5a3913eb58990690fc3c62fbc3708c
ToppCellCOVID-19-kidney-Glomerular_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

HMBOX1 DOCK4 ZNF366 FAM167B

4.75e-05194464660535b492445063d965095a50e1e299ce04c50a
ToppCellControl-Myeloid-ncMonocyte|World / Disease state, Lineage and Cell class

DOCK4 UTRN AGTPBP1 SLC49A4

4.84e-05195464b4444b67a709e82b8e2ee510924c3152cb88b051
ToppCellCOVID-19-kidney-VWF+PLVAP+VCAM1+EC|kidney / Disease (COVID-19 only), tissue and cell type

DOCK4 LDLRAD3 UTRN ZNF366

4.94e-05196464ac2c4a325efa8497a755cd31fb6a9d94d8e3bf42
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 UTRN ZNF366 FAM167B

4.94e-05196464e224338490691d92c1f70b57112fabdcc92b06a9
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 UTRN ZNF366 FAM167B

5.14e-05198464b027a141ab531d0f5d6a26811a53427e7b0771dd
ToppCelldroplet-Heart-HEART-1m-Hematologic-erythrocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK4 ALAS2 PRORP

6.41e-0575463f1ad409d1b2c5f23bf2b22137e612d627c041b97
DiseaseGlobal developmental delay

P4HTM GPAA1 NSF ZNF335

5.56e-05133464C0557874
Diseaseganglion cell inner plexiform layer thickness measurement

NSF INVS

8.76e-0428462EFO_0600005
Diseasefibromuscular dysplasia

NSF SVIL

2.16e-0344462EFO_1000938
Diseasemultiple sclerosis

SETD1A CARD11 TNFAIP8 SLC2A4RG SVIL

2.26e-03594465MONDO_0005301

Protein segments in the cluster

PeptideGeneStartEntry
IHSRKMNLTRGINLR

PSMC5

331

P62195
HAQKLMRLQNLRGGH

FTHL17

66

Q9BXU8
HRRLMTLRERHILQQ

MLLT3

511

P42568
NRHRNMLIRKGILQS

AGTPBP1

261

Q9UPW5
AHHIMRAIRQRVLRL

P4HTM

286

Q9NXG6
LHLAVMHGRLNNIRV

ANKFY1

976

Q9P2R3
ALVLHHQRKRNNLMT

LDLRAD3

191

Q86YD5
HQRKRNNLMTLPVHR

LDLRAD3

196

Q86YD5
GMFRKLNHLLERLHQ

GPAA1

341

O43292
HAIHKVLQLMLRRGE

MCM5

706

P33992
QRLRRTGMTKHEILH

HMBOX1

31

Q6NT76
IRLIQMAVALAHIRH

PDE12

466

Q6L8Q7
VQLLVAKLRARQMHH

GCGR

326

P47871
KGRLQILHIHTARMR

NSF

401

P46459
FRRRGMLVNHLSKRH

PRDM10

736

Q9NQV6
VPLHNRRHQLKMRDI

PPP1R21

241

Q6ZMI0
RRHQLKMRDIAGQAL

PPP1R21

246

Q6ZMI0
LRRAHQRNVKHMRQL

ALAS2

446

P22557
RRRMISKQFHHQLRV

EIF3C

706

Q99613
SRDLLGLHNMKRRQL

FASTKD5

711

Q7L8L6
RRQVLVGHLTHDRMK

DOCK4

126

Q8N1I0
LILKRRLIHGGQMLN

SLC49A4

141

Q96SL1
RIMKARKVLRHNALI

CUL2

686

Q13617
MHNLLIHLVRRRGQK

CCDC183

106

Q5T5S1
IHLVRRRGQKLESMQ

CCDC183

111

Q5T5S1
LHGRRLHMVKAQRQN

MFSD13A

491

Q14CX5
LLLVKLQRLMHRGSR

CARD11

841

Q9BXL7
LLRLRAQLHRLKMDQ

FAM167B

101

Q9BTA0
ANRRMHHLKINREGR

CNTNAP5

1096

Q8WYK1
MGKLHSLRELNIRRN

LRCH2

221

Q5VUJ6
QLRKHLSHLRHMKQL

INVS

931

Q9Y283
ENMKHIQIHRRARAL

UTP20

1576

O75691
LRQHKGRLEARMQIL

UTRN

3321

P46939
KRLMLLQIKGRRHVQ

SVIL

1441

O95425
KLVEALRQMRINHRG

PPM1B

391

O75688
REMLHQIIQRHLTAK

TNFAIP8

136

O95379
RNLRLLVLGRKHMLR

PRORP

436

O15091
MLTRLHQLRQGKGLI

SETD1A

686

O15047
QLGRKRSRMHLFVLH

AVPR1B

61

P47901
SGKLRLLVHQRMHTR

ZNF268

846

Q14587
AMQRHIRLVHLGRQA

SLC2A4RG

216

Q9NR83
RMDLARHQQIHTGRK

ZNF840P

561

A6NDX5
FLHRMKRIIAHAQLL

CAD

836

P27708
KNFRERGHMLRHQRI

ZNF786

711

Q8N393
LANMKRHVLIHTNIR

ZNF366

461

Q8N895
KRMNVALTRGKRHLL

ZGRF1

2021

Q86YA3
KMHLLTHIQAVANRR

ZNF335

606

Q9H4Z2
GKIRDAHRRIMLLNH

DNAJC19

76

Q96DA6
MLSCLIRHKRIHIRQ

ZNF729

191

A6NN14
RLLKHMRHENVIGLL

MAPK12

76

P53778