Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	extracellular matrix structural constituent	LAMA3 NID1 FBLN1 FBN1 FBN3	3.99e-05	188	41	5	GO:0005201
GeneOntologyBiologicalProcess	regulation of phagocytosis, engulfment	SIGLEC12 SIGLEC7 ABCA7	1.54e-05	24	42	3	GO:0060099
GeneOntologyBiologicalProcess	regulation of membrane invagination	SIGLEC12 SIGLEC7 ABCA7	1.75e-05	25	42	3	GO:1905153
GeneOntologyBiologicalProcess	negative regulation of phagocytosis, engulfment	SIGLEC12 SIGLEC7	4.03e-05	5	42	2	GO:0060101
GeneOntologyBiologicalProcess	negative regulation of membrane invagination	SIGLEC12 SIGLEC7	6.04e-05	6	42	2	GO:1905154
GeneOntologyCellularComponent	extracellular matrix	LAMA3 ADAMTS18 ADAMTS20 NID1 LAMB4 FBLN1 EYS MUC5B FBN1 ADAMTSL3 USH2A VASN FBN3	2.81e-10	656	42	13	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	LAMA3 ADAMTS18 ADAMTS20 NID1 LAMB4 FBLN1 EYS MUC5B FBN1 ADAMTSL3 USH2A VASN FBN3	2.92e-10	658	42	13	GO:0030312
GeneOntologyCellularComponent	basement membrane	LAMA3 NID1 LAMB4 FBLN1 FBN1 USH2A	1.54e-07	122	42	6	GO:0005604
GeneOntologyCellularComponent	collagen-containing extracellular matrix	LAMA3 ADAMTS20 NID1 LAMB4 FBLN1 EYS FBN1 USH2A	8.95e-06	530	42	8	GO:0062023
GeneOntologyCellularComponent	microfibril	FBN1 FBN3	3.03e-04	13	42	2	GO:0001527
HumanPheno	Lateral ventricular asymmetry	FBN1 GLI2	8.09e-06	2	15	2	HP:0100960
MousePheno	increased circulating interleukin-12 level	SIGLEC12 SIGLEC7 MARCHF2	4.92e-05	28	36	3	MP:0008617
MousePheno	abnormal right lung accessory lobe morphology	ADAMTS18 GLI2	6.42e-05	5	36	2	MP:0009571
MousePheno	overexpanded pulmonary alveolus	ADAMTS18 FBLN1 FBN1	1.15e-04	37	36	3	MP:0001183
MousePheno	abnormal circulating interleukin-12 level	SIGLEC12 SIGLEC7 MARCHF2	1.15e-04	37	36	3	MP:0008616
Domain	EGF_1	LAMA3 NID1 LAMB4 FBLN1 EYS FBN1 SCUBE2 USH2A VASN FBN3	1.46e-10	255	41	10	PS00022
Domain	cEGF	NID1 FBLN1 FBN1 SCUBE2 FBN3	2.52e-09	26	41	5	IPR026823
Domain	cEGF	NID1 FBLN1 FBN1 SCUBE2 FBN3	2.52e-09	26	41	5	PF12662
Domain	EGF-like_CS	LAMA3 NID1 LAMB4 FBLN1 EYS FBN1 SCUBE2 VASN FBN3	4.20e-09	261	41	9	IPR013032
Domain	EGF_2	LAMA3 NID1 LAMB4 FBLN1 EYS FBN1 SCUBE2 VASN FBN3	4.79e-09	265	41	9	PS01186
Domain	EGF	LAMA3 NID1 FBLN1 EYS FBN1 SCUBE2 VASN FBN3	3.73e-08	235	41	8	SM00181
Domain	Growth_fac_rcpt_	LAMA3 NID1 FBLN1 EYS FBN1 SCUBE2 FBN3	4.39e-08	156	41	7	IPR009030
Domain	EGF-like_dom	LAMA3 NID1 FBLN1 EYS FBN1 SCUBE2 VASN FBN3	5.83e-08	249	41	8	IPR000742
Domain	EGF_Ca-bd_CS	NID1 FBLN1 EYS FBN1 SCUBE2 FBN3	6.52e-08	97	41	6	IPR018097
Domain	EGF_CA	NID1 FBLN1 EYS FBN1 SCUBE2 FBN3	7.36e-08	99	41	6	PS01187
Domain	ASX_HYDROXYL	NID1 FBLN1 EYS FBN1 SCUBE2 FBN3	7.82e-08	100	41	6	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	NID1 FBLN1 EYS FBN1 SCUBE2 FBN3	1.11e-07	106	41	6	IPR000152
Domain	EGF_CA	NID1 FBLN1 EYS FBN1 SCUBE2 FBN3	2.56e-07	122	41	6	SM00179
Domain	EGF-like_Ca-bd_dom	NID1 FBLN1 EYS FBN1 SCUBE2 FBN3	2.82e-07	124	41	6	IPR001881
Domain	EGF_3	NID1 FBLN1 EYS FBN1 SCUBE2 VASN FBN3	7.13e-07	235	41	7	PS50026
Domain	EGF_CA	NID1 FBLN1 FBN1 SCUBE2 FBN3	1.21e-06	86	41	5	PF07645
Domain	Laminin_N	LAMA3 LAMB4 USH2A	5.39e-06	16	41	3	IPR008211
Domain	LAMININ_NTER	LAMA3 LAMB4 USH2A	5.39e-06	16	41	3	PS51117
Domain	Laminin_N	LAMA3 LAMB4 USH2A	5.39e-06	16	41	3	PF00055
Domain	LamNT	LAMA3 LAMB4 USH2A	5.39e-06	16	41	3	SM00136
Domain	EGF	NID1 EYS SCUBE2 VASN FBN3	7.96e-06	126	41	5	PF00008
Domain	Tyr_Pase_KIM-con	PTPN5 PTPN7	1.41e-05	3	41	2	IPR008356
Domain	FBN	FBN1 FBN3	1.41e-05	3	41	2	IPR011398
Domain	Peptidase_M12B_ADAM-TS	ADAMTS18 ADAMTS20 ADAMTSL3	1.92e-05	24	41	3	IPR013273
Domain	EGF_LAM_2	LAMA3 LAMB4 USH2A	3.83e-05	30	41	3	PS50027
Domain	EGF_LAM_1	LAMA3 LAMB4 USH2A	3.83e-05	30	41	3	PS01248
Domain	Laminin_EGF	LAMA3 LAMB4 USH2A	6.12e-05	35	41	3	PF00053
Domain	EGF_Lam	LAMA3 LAMB4 USH2A	6.12e-05	35	41	3	SM00180
Domain	LAM_G_DOMAIN	LAMA3 EYS USH2A	7.85e-05	38	41	3	PS50025
Domain	Laminin_EGF	LAMA3 LAMB4 USH2A	7.85e-05	38	41	3	IPR002049
Domain	Laminin_G_2	LAMA3 EYS USH2A	9.17e-05	40	41	3	PF02210
Domain	TB	FBN1 FBN3	9.81e-05	7	41	2	PF00683
Domain	LamG	LAMA3 EYS USH2A	1.22e-04	44	41	3	SM00282
Domain	-	FBN1 FBN3	1.31e-04	8	41	2	3.90.290.10
Domain	TB	FBN1 FBN3	1.68e-04	9	41	2	PS51364
Domain	TB_dom	FBN1 FBN3	1.68e-04	9	41	2	IPR017878
Domain	Laminin_G	LAMA3 EYS USH2A	2.79e-04	58	41	3	IPR001791
Domain	EGF_3	NID1 SCUBE2	3.06e-04	12	41	2	PF12947
Domain	EGF_dom	NID1 SCUBE2	3.06e-04	12	41	2	IPR024731
Domain	TSP_1	ADAMTS18 ADAMTS20 ADAMTSL3	3.56e-04	63	41	3	PF00090
Domain	TSP1	ADAMTS18 ADAMTS20 ADAMTSL3	3.90e-04	65	41	3	SM00209
Domain	TSP1_rpt	ADAMTS18 ADAMTS20 ADAMTSL3	3.90e-04	65	41	3	IPR000884
Domain	TSP1	ADAMTS18 ADAMTS20 ADAMTSL3	3.90e-04	65	41	3	PS50092
Domain	PLAC	ADAMTS18 ADAMTSL3	4.21e-04	14	41	2	PF08686
Domain	PLAC	ADAMTS18 ADAMTSL3	7.85e-04	19	41	2	PS50900
Domain	PLAC	ADAMTS18 ADAMTSL3	7.85e-04	19	41	2	IPR010909
Domain	ADAM_spacer1	ADAMTS18 ADAMTS20	1.16e-03	23	41	2	IPR010294
Domain	ADAM_spacer1	ADAMTS18 ADAMTS20	1.16e-03	23	41	2	PF05986
Domain	-	LAMA3 EYS USH2A	1.18e-03	95	41	3	2.60.120.200
Domain	hEGF	EYS FBN3	1.71e-03	28	41	2	PF12661
Domain	PTPc	PTPN5 PTPN7	2.83e-03	36	41	2	SM00194
Domain	Peptidase_M12B_N	ADAMTS18 ADAMTS20	3.31e-03	39	41	2	IPR002870
Domain	Pep_M12B_propep	ADAMTS18 ADAMTS20	3.31e-03	39	41	2	PF01562
Domain	TYR_PHOSPHATASE_PTP	PTPN5 PTPN7	3.31e-03	39	41	2	PS50055
Domain	DISINTEGRIN_1	ADAMTS18 ADAMTS20	3.48e-03	40	41	2	PS00427
Domain	Reprolysin	ADAMTS18 ADAMTS20	3.48e-03	40	41	2	PF01421
Domain	ADAM_MEPRO	ADAMTS18 ADAMTS20	3.48e-03	40	41	2	PS50215
Domain	DISINTEGRIN_2	ADAMTS18 ADAMTS20	3.48e-03	40	41	2	PS50214
Domain	Peptidase_M12B	ADAMTS18 ADAMTS20	3.48e-03	40	41	2	IPR001590
Domain	PTPase_domain	PTPN5 PTPN7	3.65e-03	41	41	2	IPR000242
Domain	C2-set_2	SIGLEC12 SIGLEC7	3.65e-03	41	41	2	PF08205
Domain	Disintegrin_dom	ADAMTS18 ADAMTS20	3.65e-03	41	41	2	IPR001762
Domain	Y_phosphatase	PTPN5 PTPN7	3.65e-03	41	41	2	PF00102
Domain	Kinesin_motor_CS	KIF21B KIF21A	3.65e-03	41	41	2	IPR019821
Domain	CD80_C2-set	SIGLEC12 SIGLEC7	3.65e-03	41	41	2	IPR013162
Domain	Kinesin-like_fam	KIF21B KIF21A	4.01e-03	43	41	2	IPR027640
Domain	KINESIN_MOTOR_1	KIF21B KIF21A	4.20e-03	44	41	2	PS00411
Domain	-	KIF21B KIF21A	4.20e-03	44	41	2	3.40.850.10
Domain	Kinesin_motor_dom	KIF21B KIF21A	4.20e-03	44	41	2	IPR001752
Domain	Kinesin	KIF21B KIF21A	4.20e-03	44	41	2	PF00225
Domain	KINESIN_MOTOR_2	KIF21B KIF21A	4.20e-03	44	41	2	PS50067
Domain	KISc	KIF21B KIF21A	4.20e-03	44	41	2	SM00129
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS18 ADAMTS20 MUC5B ADAMTSL3 GALNT16	5.03e-06	109	33	5	MM15164
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS18 ADAMTS20 MUC5B ADAMTSL3 GALNT16	5.50e-06	111	33	5	M27416
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	LAMA3 ADAMTS18 NID1 FBN1 FBN3	1.71e-05	140	33	5	M587
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTS18 ADAMTS20 MUC5B ADAMTSL3	1.82e-05	68	33	4	M27303
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	LAMA3 ADAMTS18 NID1 FBLN1 FBN1 FBN3	6.03e-05	300	33	6	M610
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	FBLN1 FBN1 FBN3	8.60e-05	37	33	3	M27134
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS18 ADAMTS20 ADAMTSL3	1.01e-04	39	33	3	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS18 ADAMTS20 ADAMTSL3	1.01e-04	39	33	3	MM15165
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	FBLN1 FBN1 FBN3	1.45e-04	44	33	3	M26969
Pathway	REACTOME_DISEASES_OF_METABOLISM	MTR ADAMTS18 ADAMTS20 MUC5B ADAMTSL3	2.66e-04	250	33	5	M27554
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	ADAMTS18 ADAMTS20 MUC5B ADAMTSL3	3.31e-04	143	33	4	M27275
Pathway	PID_INTEGRIN1_PATHWAY	LAMA3 NID1 FBN1	4.84e-04	66	33	3	M18
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_PTP	PTPN5 PTPN7	9.83e-04	20	33	2	M47928
Pathway	REACTOME_INTERLEUKIN_37_SIGNALING	PTPN5 PTPN7	1.09e-03	21	33	2	M27873
Pathway	WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE	FBN1 FBN3	1.54e-03	25	33	2	M39713
Pathway	REACTOME_LAMININ_INTERACTIONS	LAMA3 NID1	2.22e-03	30	33	2	M27216
Pubmed	EMILIN proteins are novel extracellular constituents of the dentin-pulp complex.	NID1 FBLN1 FBN1	9.13e-08	8	42	3	32948785
Pubmed	Laminin alpha 5 is required for lobar septation and visceral pleural basement membrane formation in the developing mouse lung.	LAMA3 NID1 GLI2	2.68e-07	11	42	3	12051813
Pubmed	Novel dendritic kinesin sorting identified by different process targeting of two related kinesins: KIF21A and KIF21B.	KIF21B KIF21A	1.42e-06	2	42	2	10225949
Pubmed	Recombinant domains of mouse nidogen-1 and their binding to basement membrane proteins and monoclonal antibodies.	NID1 FBLN1	1.42e-06	2	42	2	11589703
Pubmed	Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules.	NID1 FBLN1	1.42e-06	2	42	2	9299350
Pubmed	Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients.	FBN1 FBN3	1.42e-06	2	42	2	15221638
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	LAMA3 ADAMTS18 FBN1	4.18e-06	26	42	3	34189436
Pubmed	Sequence of extracellular mouse protein BM-90/fibulin and its calcium-dependent binding to other basement-membrane ligands.	NID1 FBLN1	4.27e-06	3	42	2	8354280
Pubmed	Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.	PTPN5 PTPN7	4.27e-06	3	42	2	16441242
Pubmed	The association of human fibulin-1 with elastic fibers: an immunohistological, ultrastructural, and RNA study.	FBLN1 FBN1	4.27e-06	3	42	2	7534784
Pubmed	The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains.	NID1 FBLN1	4.27e-06	3	42	2	9278415
Pubmed	Immunosuppressive Siglec-E ligands on mouse aorta are up-regulated by LPS via NF-κB pathway.	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	31918287
Pubmed	Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E.	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	27920204
Pubmed	Early murine T-lymphocyte activation is accompanied by a switch from N-Glycolyl- to N-acetyl-neuraminic acid and generation of ligands for siglec-E.	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	21835922
Pubmed	Sialylated ligands on pathogenic Trypanosoma cruzi interact with Siglec-E (sialic acid-binding Ig-like lectin-E).	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	19552697
Pubmed	Targeting the Siglec-sialic acid axis promotes antitumor immune responses in preclinical models of glioblastoma.	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	37467314
Pubmed	Polysialic acid promotes remyelination in cerebellar slice cultures by Siglec-E-dependent modulation of microglia polarization.	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	37492129
Pubmed	Ablation of Siglec-E augments brain inflammation and ischemic injury.	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	35858866
Pubmed	Human-specific elimination of epithelial Siglec-XII suppresses the risk of inflammation-driven colorectal cancers.	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	38990656
Pubmed	Siglecs-7/9 function as inhibitory immune checkpoints in vivo and can be targeted to enhance therapeutic antitumor immunity.	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	34155121
Pubmed	Polysialic acid and Siglec-E orchestrate negative feedback regulation of microglia activation.	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	32725371
Pubmed	The human sialic acid-binding immunoglobulin-like lectin Siglec-9 and its murine homolog Siglec-E control osteoclast activity and bone resorption.	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	33007530
Pubmed	Involvement of sulfates from cruzipain, a major antigen of Trypanosoma cruzi, in the interaction with immunomodulatory molecule Siglec-E.	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	26047932
Pubmed	Leishmania donovani Utilize Sialic Acids for Binding and Phagocytosis in the Macrophages through Selective Utilization of Siglecs and Impair the Innate Immune Arm.	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	27494323
Pubmed	Siglec-9 acts as an immune-checkpoint molecule on macrophages in glioblastoma, restricting T-cell priming and immunotherapy response.	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	37460871
Pubmed	Siglec genes confer resistance to systemic lupus erythematosus in humans and mice.	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	29503442
Pubmed	Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo.	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	24391502
Pubmed	Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.	FBN1 FBN3	8.53e-06	4	42	2	25034023
Pubmed	Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer.	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	25225409
Pubmed	The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis.	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	38454157
Pubmed	Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells.	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	30130255
Pubmed	Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing.	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	30910970
Pubmed	O-Acetylation of Capsular Polysialic Acid Enables Escherichia coli K1 Escaping from Siglec-Mediated Innate Immunity and Lysosomal Degradation of E. coli-Containing Vacuoles in Macrophage-Like Cells.	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	34878295
Pubmed	Siglec receptors impact mammalian lifespan by modulating oxidative stress.	SIGLEC12 SIGLEC7	8.53e-06	4	42	2	25846707
Pubmed	Siglec-E promotes β2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung.	SIGLEC12 SIGLEC7	1.42e-05	5	42	2	24895121
Pubmed	Microglial CD33-related Siglec-E inhibits neurotoxicity by preventing the phagocytosis-associated oxidative burst.	SIGLEC12 SIGLEC7	1.42e-05	5	42	2	24227736
Pubmed	Complete sequence, recombinant analysis and binding to laminins and sulphated ligands of the N-terminal domains of laminin alpha3B and alpha5 chains.	LAMA3 NID1	1.42e-05	5	42	2	11829758
Pubmed	Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression.	SIGLEC12 SIGLEC7	1.42e-05	5	42	2	16857734
Pubmed	A soluble form of Siglec-9 provides an antitumor benefit against mammary tumor cells expressing MUC1 in transgenic mice.	SIGLEC12 SIGLEC7	1.42e-05	5	42	2	24924635
Pubmed	Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of β-catenin and subsequent cell growth.	SIGLEC12 SIGLEC7	1.42e-05	5	42	2	24045940
Pubmed	Siglec-E is up-regulated and phosphorylated following lipopolysaccharide stimulation in order to limit TLR-driven cytokine production.	SIGLEC12 SIGLEC7	1.42e-05	5	42	2	19933851
Pubmed	Siglec-9 modulated IL-4 responses in the macrophage cell line RAW264.	SIGLEC12 SIGLEC7	1.42e-05	5	42	2	26540411
Pubmed	The prognostic impact of SIGLEC5-induced impairment of CD8+ T cell activation in sepsis.	SIGLEC12 SIGLEC7	1.42e-05	5	42	2	37890368
Pubmed	Siglec-E Negatively Regulates the Activation of TLR4 by Controlling Its Endocytosis.	SIGLEC12 SIGLEC7	1.42e-05	5	42	2	27619995
Pubmed	Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins.	NID1 FBLN1	1.42e-05	5	42	2	11733994
Pubmed	Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin-dependent signaling.	SIGLEC12 SIGLEC7	2.13e-05	6	42	2	23315163
Pubmed	Molecular cloning of MIS, a myeloid inhibitory siglec, that binds protein-tyrosine phosphatases SHP-1 and SHP-2.	SIGLEC12 SIGLEC7	2.13e-05	6	42	2	11278955
Pubmed	Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteins.	NID1 FBLN1	2.13e-05	6	42	2	10544250
Pubmed	Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.	LAMA3 NID1 FBLN1 FBN1	2.95e-05	146	42	4	27068509
Pubmed	mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2.	SIGLEC12 SIGLEC7	2.98e-05	7	42	2	11171044
Pubmed	[Functions and molecular evolution of Siglecs, a family of sialic acid receptor proteins].	SIGLEC12 SIGLEC7	2.98e-05	7	42	2	18453149
Pubmed	Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen.	SIGLEC12 SIGLEC7	2.98e-05	7	42	2	28100677
Pubmed	The murine inhibitory receptor mSiglec-E is expressed broadly on cells of the innate immune system whereas mSiglec-F is restricted to eosinophils.	SIGLEC12 SIGLEC7	2.98e-05	7	42	2	15048729
Pubmed	Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1.	SIGLEC12 SIGLEC7	3.97e-05	8	42	2	25187624
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	LAMA3 NID1 FBLN1 FBN1	4.98e-05	167	42	4	22159717
Pubmed	Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.	FBLN1 FBN1	5.10e-05	9	42	2	12122015
Pubmed	Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.	SIGLEC12 SIGLEC7	6.37e-05	10	42	2	25320078
Pubmed	Binding of mouse and human fibulin-2 to extracellular matrix ligands.	NID1 FBLN1	7.78e-05	11	42	2	7500359
Pubmed	Selective Response to Bacterial Infection by Regulating Siglec-E Expression.	SIGLEC12 SIGLEC7	7.78e-05	11	42	2	32889432
Pubmed	Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney function.	LAMA3 NID1	9.32e-05	12	42	2	16750824
Pubmed	Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.	ADAMTS18 ADAMTS20	9.32e-05	12	42	2	25770910
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTS18 ADAMTS20 ADAMTSL3	1.04e-04	75	42	3	20637190
Pubmed	CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder.	SIGLEC12 SIGLEC7	1.10e-04	13	42	2	35921817
Pubmed	Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane.	NID1 FBLN1	1.10e-04	13	42	2	12682087
Pubmed	Transcriptome-based systematic identification of extracellular matrix proteins.	LAMA3 NID1 FBLN1	1.21e-04	79	42	3	18757743
Pubmed	Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome.	NID1 GLI2	1.28e-04	14	42	2	19783738
Pubmed	Basement membrane composition in the early mouse embryo day 7.	LAMA3 NID1	1.48e-04	15	42	2	15895400
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	PTPN5 KANK4 PTPN7 FBN1 AKAP17A AOAH	1.50e-04	674	42	6	37196079
Pubmed	ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice.	LAMA3 ADAMTS18	1.69e-04	16	42	2	30579834
Pubmed	Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice.	NID1 FBLN1	1.69e-04	16	42	2	11564885
Pubmed	Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins.	KANK4 NID1	1.69e-04	16	42	2	33253712
Pubmed	Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development.	LAMA3 GLI2	1.69e-04	16	42	2	12533516
Pubmed	Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation.	ADAMTS20 FBLN1	1.91e-04	17	42	2	22183742
Pubmed	Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53.	LAMA3 LAMB4	2.15e-04	18	42	2	11311202
Pubmed	ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.	ADAMTS18 FBN1	2.15e-04	18	42	2	39040056
Pubmed	A second uniquely human mutation affecting sialic acid biology.	SIGLEC12 SIGLEC7	2.15e-04	18	42	2	11546777
Pubmed	Proteomics characterization of extracellular space components in the human aorta.	NID1 FBLN1 FBN1	2.51e-04	101	42	3	20551380
Pubmed	ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.	ADAMTS20 FBLN1	2.67e-04	20	42	2	19922873
Pubmed	A role for the primary cilium in Notch signaling and epidermal differentiation during skin development.	NID1 GLI2	2.95e-04	21	42	2	21703454
Pubmed	Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis.	ADAMTS20 GLI2	3.54e-04	23	42	2	30814516
Pubmed	GATA6 Regulates Aortic Valve Remodeling, and Its Haploinsufficiency Leads to Right-Left Type Bicuspid Aortic Valve.	FBLN1 FBN1	3.54e-04	23	42	2	29567669
Pubmed	Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.	SIGLEC12 SIGLEC7	3.86e-04	24	42	2	15331780
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	FBLN1 FBN1 CRMP1	3.97e-04	118	42	3	21078624
Pubmed	Defects in the cappuccino (cno) gene on mouse chromosome 5 and human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent mechanism.	MTR CRMP1	4.20e-04	25	42	2	11110696
Pubmed	Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.	KANK4 ADAMTS18 FBLN1	5.27e-04	130	42	3	28705898
Pubmed	The basement membrane of hair follicle stem cells is a muscle cell niche.	NID1 FBLN1	5.28e-04	28	42	2	21335239
Pubmed	Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.	NID1 FBLN1 FBN1	5.88e-04	135	42	3	28675934
Pubmed	ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation.	ADAMTS18 FBN1	6.06e-04	30	42	2	32882513
Pubmed	TBX1 is required for normal stria vascularis and semicircular canal development.	NID1 FBN1	6.47e-04	31	42	2	31550482
Pubmed	SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.	PTPN5 ADAMTS20 PDE5A PTPN7 ZNF23 MARCHF2	7.62e-04	915	42	6	32393512
Pubmed	Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.	NID1 FBLN1 FBN1	8.45e-04	153	42	3	25037231
Pubmed	Galnt1 is required for normal heart valve development and cardiac function.	ADAMTS20 GALNT16	8.74e-04	36	42	2	25615642
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	PTPN5 KIF21B ADAMTS20 KIF21A CRMP1	8.80e-04	621	42	5	22794259
Pubmed	Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.	ADAMTS18 FBN1	9.23e-04	37	42	2	34323105
Pubmed	All kinesin superfamily protein, KIF, genes in mouse and human.	KIF21B KIF21A	9.23e-04	37	42	2	11416179
Pubmed	The transcription factor XBP1 is selectively required for eosinophil differentiation.	SIGLEC12 SIGLEC7	9.23e-04	37	42	2	26147683
Pubmed	Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.	ADAMTS20 ABCA7	9.23e-04	37	42	2	24162737
Pubmed	Assessment of community efforts to advance network-based prediction of protein-protein interactions.	FBLN1 AKAP17A VASN AOAH MARCHF2	9.39e-04	630	42	5	36949045
Pubmed	Sterile Inflammation Enhances ECM Degradation in Integrin β1 KO Embryonic Skin.	LAMA3 NID1	9.74e-04	38	42	2	27653694
Pubmed	Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis.	ADAMTS18 FBLN1	9.74e-04	38	42	2	18267097
Interaction	FBLN2 interactions	NID1 FBLN1 FBN1 ARIH1	1.07e-05	66	42	4	int:FBLN2
Interaction	ELN interactions	NID1 FBLN1 FBN1	2.96e-05	29	42	3	int:ELN
Interaction	LAMC2 interactions	LAMA3 NID1 FBLN1	3.29e-05	30	42	3	int:LAMC2
Interaction	COL4A3 interactions	NID1 FBLN1 USH2A	3.29e-05	30	42	3	int:COL4A3
Cytoband	12q12	ADAMTS20 KIF21A	8.60e-04	47	42	2	12q12
Cytoband	1q43	MTR NID1	1.01e-03	51	42	2	1q43
Cytoband	Ensembl 112 genes in cytogenetic band chr12q12	ADAMTS20 KIF21A	1.54e-03	63	42	2	chr12q12
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	PTPN5 MUC5B SCUBE2 GVINP1	1.74e-03	564	42	4	chr11p15
GeneFamily	Laminin subunits	LAMA3 LAMB4	1.30e-04	12	26	2	626
GeneFamily	Protein tyrosine phosphatases, non-receptor type	PTPN5 PTPN7	3.00e-04	18	26	2	812
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS18 ADAMTS20	3.35e-04	19	26	2	50
GeneFamily	CD molecules\|C2-set domain containing\|Sialic acid binding Ig like lectins	SIGLEC12 SIGLEC7	7.35e-04	28	26	2	745
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF21B KIF21A	1.98e-03	46	26	2	622
Coexpression	NABA_ECM_GLYCOPROTEINS	LAMA3 NID1 LAMB4 FBLN1 EYS FBN1 USH2A FBN3	8.04e-10	196	42	8	M3008
Coexpression	NABA_MATRISOME	LAMA3 ADAMTS18 ADAMTS20 NID1 LAMB4 FBLN1 EYS MUC5B FBN1 SCUBE2 ADAMTSL3 USH2A FBN3	4.17e-09	1026	42	13	M5889
Coexpression	NABA_CORE_MATRISOME	LAMA3 NID1 LAMB4 FBLN1 EYS FBN1 USH2A FBN3	1.15e-08	275	42	8	M5884
Coexpression	NABA_BASEMENT_MEMBRANES	LAMA3 NID1 LAMB4 USH2A	4.99e-07	40	42	4	M5887
Coexpression	NABA_MATRISOME	LAMA3 ADAMTS18 ADAMTS20 NID1 FBLN1 MUC5B FBN1 SCUBE2 ADAMTSL3	2.52e-05	1008	42	9	MM17056
Coexpression	SNIJDERS_AMPLIFIED_IN_HEAD_AND_NECK_TUMORS	LAMA3 EYS GLI2	2.86e-05	37	42	3	M12802
Coexpression	CUI_DEVELOPING_HEART_C3_FIBROBLAST_LIKE_CELL	NID1 FBLN1 FBN1 ADAMTSL3	3.70e-05	117	42	4	M39300
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_1000	NCOA2 KANK4 LAMA3 ADAMTS18 ADAMTS20 PDE5A GLI2 CRMP1 PDLIM4	2.26e-05	806	42	9	gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000
CoexpressionAtlas	dev gonad_e12.5_M_InterstitLeydig_MafB_k-means-cluster#1_top-relative-expression-ranked_1000	KANK4 PDE5A FBLN1 FBN1 VASN GLI2	3.11e-05	310	42	6	gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_k1_1000
CoexpressionAtlas	dev gonad_e12.5_M_InterstitTestis_Sma_k-means-cluster#4_top-relative-expression-ranked_1000	KANK4 NID1 PDE5A FBN1 GLI2	3.63e-05	191	42	5	gudmap_dev gonad_e12.5_M_InterstitTestis_Sma_k4_1000
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_induced-Ectoderm_top-relative-expression-ranked_500	PTPN5 KANK4 ADAMTS18 ADAMTS20 SCUBE2 FBN3 AOAH	4.77e-05	495	42	7	PCBC_ECTO_500
CoexpressionAtlas	dev gonad_e12.5_M_InterstitLeydig_MafB_top-relative-expression-ranked_1000	KANK4 NID1 PDE5A FBLN1 FBN1 ZNF618 VASN GLI2	1.12e-04	768	42	8	gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_1000
CoexpressionAtlas	dev gonad_e13.5_M_InterstitTestis_Sma_top-relative-expression-ranked_1000	KANK4 NID1 PDE5A FBLN1 FBN1 ZNF618 VASN GLI2	1.21e-04	777	42	8	gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_1000
CoexpressionAtlas	Ectoderm Differentiated Cells_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05	PTPN5 NID1 FAM120B FBN1 SCUBE2 ABCA7 GALNT16 VASN PDLIM4	2.07e-04	1075	42	9	PCBC_ratio_ECTO_vs_DE_cfr-2X-p05
CoexpressionAtlas	dev gonad_e13.5_M_InterstitTestis_Sma_k-means-cluster#1_top-relative-expression-ranked_500	KANK4 PDE5A FBN1 GLI2	2.52e-04	156	42	4	gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_k1_500
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NID1 PDE5A FBLN1 FBN1 ADAMTSL3 GLI2	2.58e-08	192	42	6	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NID1 FBN1 ADAMTSL3 GALNT16 VASN PDLIM4	2.74e-08	194	42	6	7b6ec45adb7ece3c8a7b78c5782413b5825effe2
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NID1 FBLN1 FBN1 ADAMTSL3 GLI2 PDLIM4	2.83e-08	195	42	6	ff0aa455e9844a6d7ae57ff59fb6cea825cf1fc2
ToppCell	Adult-Mesenchymal\|Adult / Lineage, Cell type, age group and donor	NID1 PDE5A FBLN1 FBN1 ADAMTSL3 GLI2	3.10e-08	198	42	6	26e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic-Fibro_adventitial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NID1 FBLN1 FBN1 ADAMTSL3 GALNT16 VASN	3.29e-08	200	42	6	b04831708fa20471a127b87e8db3728b6e729ce8
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN7 ADAMTSL3 GALNT16 GLI2 AOAH	2.78e-07	148	42	5	dfd3f2c4b884ea9e23831a242a89ac985b409640
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NID1 FBLN1 FBN1 GALNT16 GLI2	5.68e-07	171	42	5	972fab891135bd755d5526cbc5a963200067b0a6
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NID1 FBLN1 FBN1 GALNT16 GLI2	5.68e-07	171	42	5	2a77ed79c6f2e700e789c80451a70ecb31639719
ToppCell	-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	PTPN5 NID1 FBLN1 FBN1 ADAMTSL3	7.12e-07	179	42	5	10fadbaa1b6d21cbf9f354d717cc4c225619f4fd
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NID1 FBLN1 FBN1 SCUBE2 ADAMTSL3	7.72e-07	182	42	5	3dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FBLN1 FBN1 ADAMTSL3 GALNT16 VASN	8.15e-07	184	42	5	4a9f798c67b9998bffe44242b210cc1e224ff5b1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NID1 FBLN1 FBN1 ADAMTSL3 GLI2	8.15e-07	184	42	5	e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FBLN1 FBN1 SCUBE2 ZNF618 VASN	8.37e-07	185	42	5	355b03c7ea438681e11a2b872c798c9ea26e1486
ToppCell	facs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID1 FBLN1 FBN1 ADAMTSL3 VASN	8.60e-07	186	42	5	a7ab70b049742dfe7ee30557031bfac6412edf52
ToppCell	5'-GW_trimst-2-LymphNode-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KANK4 LAMA3 GALNT16 VASN CRMP1	8.83e-07	187	42	5	b8f88599e22b9b345c7ec3bbecd87a8b2a033f9f
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID1 FBLN1 FBN1 ADAMTSL3 GALNT16	8.83e-07	187	42	5	4e553721fa5598cb211f44e3226280b7e6885484
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID1 FBLN1 FBN1 ADAMTSL3 GALNT16	8.83e-07	187	42	5	d36e7fc6125e7a4310499365022d38f34b757a73
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID1 FBLN1 FBN1 ADAMTSL3 GALNT16	8.83e-07	187	42	5	827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell	droplet-Bladder-Unstain-18m-Epithelial-bladder_mesenchymal_cell_(Scara5+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID1 FBLN1 FBN1 ADAMTSL3 VASN	8.83e-07	187	42	5	7beba2a5d5978f2ae7d8bde10815705cf2572211
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NID1 PDE5A ADAMTSL3 VASN CRMP1	8.83e-07	187	42	5	8ee3bf885897efd634c3a0567637142a9f55e693
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NID1 FBLN1 FBN1 GALNT16 VASN	9.30e-07	189	42	5	d531399749409d614adca13d181830c6e3287508
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	NID1 FBLN1 FBN1 ADAMTSL3 GLI2	9.55e-07	190	42	5	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	ASK440-Mesenchymal\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	PDE5A FBLN1 FBN1 ADAMTSL3 GLI2	9.80e-07	191	42	5	f12959eebb4167e1aa03de05d7711a702c58b3c9
ToppCell	ASK440-Mesenchymal-Fibroblast\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	PDE5A FBLN1 FBN1 ADAMTSL3 GLI2	9.80e-07	191	42	5	387296b5377ef6839f0812e5b3529a10b5f7d530
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NID1 FBLN1 FBN1 ADAMTSL3 GLI2	9.80e-07	191	42	5	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NID1 FBLN1 FBN1 ADAMTSL3 GLI2	1.01e-06	192	42	5	bc84b9ce01b4d826a682842ab8a395dac9b91183
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID1 FBLN1 FBN1 ADAMTSL3 GALNT16	1.01e-06	192	42	5	853a930e0641ffb50cbb4cef5837c70d75c3fc39
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NID1 FBLN1 FBN1 ADAMTSL3 GLI2	1.01e-06	192	42	5	5105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NID1 PDE5A FBLN1 FBN1 GLI2	1.01e-06	192	42	5	d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID1 FBLN1 FBN1 ADAMTSL3 GLI2	1.01e-06	192	42	5	8937a59f6bbe07f671bdabbd3707dc9c17a14cd9
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID1 FBLN1 FBN1 ADAMTSL3 GLI2	1.01e-06	192	42	5	e4a7f2673f801b008ca67291db2fb2b9fd2955b8
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID1 FBLN1 FBN1 ADAMTSL3 GLI2	1.01e-06	192	42	5	ac1477433704573f95111eee6263b93668d2845e
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID1 FBLN1 FBN1 ADAMTSL3 GALNT16	1.01e-06	192	42	5	d2c03490c5e835d0f0a732803093c64b8d4b4029
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell\|Adult / Lineage, Cell type, age group and donor	NID1 FBLN1 FBN1 ADAMTSL3 GLI2	1.01e-06	192	42	5	d21f0f577156f17c899b08871046a26b88aea011
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID1 FBLN1 FBN1 ADAMTSL3 GALNT16	1.01e-06	192	42	5	49281626ecad0456fdbded2378b7028d7b589686
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NID1 FBLN1 FBN1 ADAMTSL3 GLI2	1.01e-06	192	42	5	0ab1176cfbb0de8dd1f22c6e2c41265cf6c10ee1
ToppCell	droplet-Fat-Mat-18m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID1 FBLN1 FBN1 ADAMTSL3 PDLIM4	1.03e-06	193	42	5	ebd090d7801480b3cee45caac3d30cc991836769
ToppCell	droplet-Fat-Mat-18m-Mesenchymal-Cd34+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID1 FBLN1 FBN1 ADAMTSL3 PDLIM4	1.03e-06	193	42	5	22c58032e58730715224d7934968ce92d150b0e8
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NID1 PDE5A FBLN1 FBN1 GLI2	1.03e-06	193	42	5	99525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCell	ILEUM-inflamed-(8)_Smooth_muscle_cells\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	NID1 PDE5A LAMB4 FBLN1 ADAMTSL3	1.03e-06	193	42	5	084c88f08ce0ecd6c9f4334caed370eb2154f896
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NID1 FBLN1 FBN1 ADAMTSL3 GLI2	1.03e-06	193	42	5	9ab47b360bee1d4f1092c2269e58acebe9584021
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NID1 FBLN1 FBN1 ADAMTSL3 VASN	1.03e-06	193	42	5	25248b8e65d558b1a96a87c93e3e5b4c0ba168fe
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NID1 FBLN1 FBN1 ADAMTSL3 VASN	1.03e-06	193	42	5	f1f1097204e07a7bed416425b8256942038a734f
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Mesenchymal-mesenchymal_stem_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID1 FBLN1 FBN1 ADAMTSL3 VASN	1.03e-06	193	42	5	160691b671710be10220803d788c2c961c236af1
ToppCell	droplet-Fat-Mat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID1 FBLN1 FBN1 ADAMTSL3 PDLIM4	1.03e-06	193	42	5	573ad2f848bede1fe20c7b4b352a9242ec294725
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NID1 FBLN1 ADAMTSL3 GALNT16 CRMP1	1.06e-06	194	42	5	e2db75f4de114631b8bda4e188f84446545538b7
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NID1 PDE5A ADAMTSL3 VASN CRMP1	1.06e-06	194	42	5	8f19e553f18c313c2a2ff9453884b9484b255d71
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NID1 PDE5A ADAMTSL3 VASN CRMP1	1.06e-06	194	42	5	67fbb81b7d20cb63be27b2a2beea5b5689f8e08c
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell\|Adult / Lineage, Cell type, age group and donor	NID1 PDE5A FBLN1 FBN1 GLI2	1.08e-06	195	42	5	61c9e09fc84d1012e472185d70ad0a06cee30d6e
ToppCell	Mesenchymal_cells-Endosteal_fibro.\|World / Lineage and Cell class	NID1 FBLN1 FBN1 ADAMTSL3 VASN	1.08e-06	195	42	5	d53974d1866e23c894ffd492ea11d20422919b11
ToppCell	facs-Trachea-18m-Mesenchymal\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NID1 FBLN1 FBN1 ADAMTSL3 VASN	1.08e-06	195	42	5	0d1876f6fdc1eafeb60d6fd7da5bce737d2b4a5a
ToppCell	PCW_07-8.5-Mesenchymal\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	NID1 PDE5A FBLN1 FBN1 GLI2	1.11e-06	196	42	5	8e10802f52e5e1853ea4ad34bf9a32a34e6112b5
ToppCell	Children_(3_yrs)-Mesenchymal\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NID1 FBLN1 FBN1 ADAMTSL3 GLI2	1.11e-06	196	42	5	bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NID1 FBN1 ADAMTSL3 GALNT16 VASN	1.11e-06	196	42	5	ed6047b48b6a96baa6a90c7af784e7c34b32824d
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN1 FBN1 GALNT16 VASN KIF21A	1.11e-06	196	42	5	2029f58ce6a7b8c35d3a7496c3341391990909ce
ToppCell	nucseq-Mesenchymal-Fibroblastic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NID1 FBLN1 FBN1 ADAMTSL3 GLI2	1.11e-06	196	42	5	7d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ADAMTS18 NID1 PDE5A FBLN1 VASN	1.14e-06	197	42	5	af819b0561c8db582c5b466d804153d69d3297e0
ToppCell	COPD-Stromal-Fibroblast\|World / Disease state, Lineage and Cell class	NID1 FBLN1 FBN1 ADAMTSL3 VASN	1.17e-06	198	42	5	2f13c0b3372af53d1bd85f9546f315c878580a71
ToppCell	nucseq-Mesenchymal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NID1 FBLN1 FBN1 ADAMTSL3 GLI2	1.17e-06	198	42	5	8f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KANK4 NID1 PDE5A FBLN1 FBN1	1.17e-06	198	42	5	f1374f7a50244d59c766ac41f44c08c9117407d2
ToppCell	Mesenchymal\|World / Lineage, Cell type, age group and donor	NID1 FBLN1 FBN1 ADAMTSL3 GLI2	1.20e-06	199	42	5	4bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCell	Fibroblasts\|World / lung cells shred on cell class, cell subclass, sample id	NID1 PDE5A FBLN1 FBN1 GLI2	1.20e-06	199	42	5	e2b6752fcabd5249a166486ae6796f2c97c1fcaf
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NID1 PDE5A FBLN1 FBN1 VASN	1.20e-06	199	42	5	8d71e1fc92ee24deedf23fbb1a85a7fba0d8d436
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NID1 PDE5A FBLN1 FBN1 VASN	1.20e-06	199	42	5	e1f1950d6f840485e263b83dc81b98910be3ae7a
ToppCell	10x3'2.3-week_17-19-Mesenchymal_fibro-stroma-arteriolar_fibroblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	FBLN1 FBN1 ADAMTSL3 GALNT16 GLI2	1.20e-06	199	42	5	95d95e9b7bd3933188998ae94986213eb0f1e5ea
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	NID1 PDE5A FBLN1 FBN1 ADAMTSL3	1.20e-06	199	42	5	6b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-AF2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NID1 FBLN1 FBN1 ADAMTSL3 VASN	1.20e-06	199	42	5	993fa050a095017135a6e723c77cd38b9d782e58
ToppCell	(5)_Fibroblast-F\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	FBLN1 FBN1 ADAMTSL3 GALNT16 PDLIM4	1.20e-06	199	42	5	1f66db4f502de4a5159cde90fcb3befb26b8d375
ToppCell	cellseq-Mesenchymal\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NID1 PDE5A FBLN1 FBN1 VASN	1.23e-06	200	42	5	238285fc372ce2e5e4341fc3084a3a833bf4a0a6
ToppCell	Biopsy_IPF-Mesenchymal-PLIN2+_Fibroblasts\|Biopsy_IPF / Sample group, Lineage and Cell type	NID1 FBLN1 FBN1 ADAMTSL3 VASN	1.23e-06	200	42	5	2c5626ea8fb4b702d4560117e53edf6cfcf1971e
ToppCell	distal-mesenchymal\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NID1 PDE5A FBLN1 ADAMTSL3 VASN	1.23e-06	200	42	5	b54137a4545690f51e154bb05964eaa650c3ca8e
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NID1 FBLN1 FBN1 ADAMTSL3 GLI2	1.23e-06	200	42	5	ad3fdcef895400f929f2ae12ff9bd85fd46adb3a
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	NID1 PDE5A ADAMTSL3 GALNT16 VASN	1.23e-06	200	42	5	b5b5a32925f225610fe25a021a742d6397162863
ToppCell	Bronchial-10x5prime-Stromal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NID1 FBLN1 FBN1 ADAMTSL3 VASN	1.23e-06	200	42	5	5ea12e17f50fefbf5534e487af3392b2fa2d13ad
ToppCell	Parenchyma_Control_(B.)-Stromal-TX-Fibroblasts-4\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	FBLN1 FBN1 VASN GLI2 PDLIM4	1.23e-06	200	42	5	7642a14855589b0b3f68dbdc9e4d3fc7291854f7
ToppCell	Bronchial-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NID1 FBLN1 FBN1 ADAMTSL3 GLI2	1.23e-06	200	42	5	389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NID1 FBLN1 FBN1 GALNT16 VASN	1.23e-06	200	42	5	3e6730c9ed7003a4acf501f699a4965a7a50f946
ToppCell	3'-Parenchyma_lung-Mesenchymal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NID1 PDE5A FBLN1 FBN1 VASN	1.23e-06	200	42	5	ba5ed66b05caa1be0bbf8d54c4e72a782b8d9833
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-Neuroepithelial\|2m / Sample Type, Dataset, Time_group, and Cell type.	KANK4 NID1 PDE5A FBLN1 FBN1	1.23e-06	200	42	5	3da9441c0f1e242f0d195de47ecd4c24dfdca232
ToppCell	Tracheal-10x3prime_v2-Stromal-Pericyte-Muscle_pericyte_pulmonary\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	NID1 PDE5A ADAMTSL3 VASN CRMP1	1.23e-06	200	42	5	8158f4eaeff945a6788c8e732b7a1b0d78052a06
ToppCell	Parenchymal-10x5prime-Stromal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NID1 PDE5A FBLN1 FBN1 VASN	1.23e-06	200	42	5	2e525c0d9684e7a2275edb04e1addb6fc6a872e5
ToppCell	Bronchus_Control_(B.)-Stromal-TX\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	NID1 PDE5A FBLN1 FBN1 VASN	1.23e-06	200	42	5	69b41f5fb370aa8840a9ad7919d03ef1e57d1b5b
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	NID1 PDE5A FBLN1 FBN1 ADAMTSL3	1.23e-06	200	42	5	a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCell	Biopsy_Other_PF-Mesenchymal-Smooth_Muscle_cells\|Biopsy_Other_PF / Sample group, Lineage and Cell type	NID1 PDE5A ADAMTSL3 GALNT16 VASN	1.23e-06	200	42	5	55ac281901309e30978da1f7489386e54489721e
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NID1 FBLN1 FBN1 GALNT16 VASN	1.23e-06	200	42	5	14f3fe19b6647b32a5e28d717235741997d8522c
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-4-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FBLN1 FBN1 VASN GLI2 PDLIM4	1.23e-06	200	42	5	444c72334df421375ae6fc69b0adfd4950d49a43
ToppCell	distal-1-mesenchymal-Adventitial_Fibroblast\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FBLN1 FBN1 ADAMTSL3 VASN PDLIM4	1.23e-06	200	42	5	738060ed65fa5473fdb39e686f7cdecc059ed92c
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	NID1 PDE5A FBLN1 FBN1 ADAMTSL3	1.23e-06	200	42	5	09537dc25f8b8b4654a7c183827ee1522a41a4e0
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-4\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	FBLN1 FBN1 VASN GLI2 PDLIM4	1.23e-06	200	42	5	5826c17da67bdaba3a828792279004218d8260c8
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-Neuroepithelial-Proteoglycan-expressing_cell\|2m / Sample Type, Dataset, Time_group, and Cell type.	KANK4 NID1 PDE5A FBLN1 FBN1	1.23e-06	200	42	5	eed2bafddcd041ef5fcc4d1d31edb8be4d83ce01
ToppCell	Parenchyma_Control_(B.)-Stromal-TX\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	NID1 PDE5A FBLN1 FBN1 VASN	1.23e-06	200	42	5	0a86656d48e4238d0e4d592d477d29f7ba7c2ec0
ToppCell	Parenchymal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NID1 FBLN1 FBN1 ADAMTSL3 GLI2	1.23e-06	200	42	5	cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NID1 FBLN1 FBN1 ADAMTSL3 GLI2	1.23e-06	200	42	5	cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCell	Tracheal-10x3prime_v2-Stromal-Pericyte\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	NID1 PDE5A ADAMTSL3 VASN CRMP1	1.23e-06	200	42	5	600d56257b1b0cda8ed2fd0db92c6551711f7d6d
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte\|LPS_only / Treatment groups by lineage, cell group, cell type	NID1 PDE5A ADAMTSL3 GALNT16 VASN	1.23e-06	200	42	5	8c8ef2b19ab5b1bfc0fae6c38a330f464f28e86f
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	NID1 PDE5A FBLN1 FBN1 VASN	1.23e-06	200	42	5	3fa7d9ea67f9cc55478d085da53babd03dbe9bb1
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	NID1 PDE5A FBLN1 FBN1 ADAMTSL3	1.23e-06	200	42	5	a9ff3210127000b3dd9e97136163c98c2b0817d7
ToppCell	Parenchyma_Control_(B.)-Stromal-TX-Fibroblasts-2,_SCARA5\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	NID1 FBLN1 FBN1 VASN PDLIM4	1.23e-06	200	42	5	ef30f9b68bfdb8d947ed399603e4dd0d5ff0144d
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NID1 FBLN1 FBN1 ADAMTSL3 GLI2	1.23e-06	200	42	5	311fab076f2ceb258e3970eb21e39344b894042a
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-2,_SCARA5-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NID1 FBLN1 FBN1 VASN PDLIM4	1.23e-06	200	42	5	b28bfe6eb96b4db9cb27f0fc8fc39259c125f05e
Drug	Rgd Peptide	LAMA3 NID1 LAMB4 FBLN1 FBN1 FBN3	4.80e-06	239	42	6	CID000104802
Drug	Testosterone propionate [57-85-2]; Up 200; 11.6uM; MCF7; HT_HG-U133A	ADAMTS20 LAMB4 PTPN7 SIGLEC7 CRMP1	2.88e-05	195	42	5	5636_UP
Drug	Harmane hydrochloride [21655-84-5]; Up 200; 18.2uM; MCF7; HT_HG-U133A	NID1 FBN1 SIGLEC7 AOAH PDLIM4	3.02e-05	197	42	5	4408_UP
Drug	Tetracaone hydrochloride [136-47-0]; Up 200; 13.2uM; MCF7; HT_HG-U133A	FBLN1 SIGLEC7 ADAMTSL3 GLI2 CRMP1	3.02e-05	197	42	5	2888_UP
Drug	Cephalexin monohydrate [23325-78-2]; Up 200; 11uM; MCF7; HT_HG-U133A	LAMB4 FBLN1 FBN1 SIGLEC7 CRMP1	3.10e-05	198	42	5	5615_UP
Drug	Thioperamide maleate [106243-16-7]; Up 200; 9.8uM; MCF7; HT_HG-U133A	KIF21B NID1 FBLN1 MUC5B CRMP1	3.10e-05	198	42	5	5635_UP
Drug	CP-320650-01 [172079-28-6]; Up 200; 1uM; MCF7; HT_HG-U133A	FBLN1 FBN1 SIGLEC7 ABCA7 PDLIM4	3.10e-05	198	42	5	3908_UP
Drug	Imipenem [74431-23-5]; Up 200; 13.4uM; MCF7; HT_HG-U133A	NID1 PTPN7 FBN1 USH2A CRMP1	3.17e-05	199	42	5	5997_UP
Disease	connective tissue disease (implicated_via_orthology)	FBN1 FBN3	5.65e-06	3	41	2	DOID:65 (implicated_via_orthology)
Disease	spina bifida (is_implicated_in)	MTR GLI2	2.82e-05	6	41	2	DOID:0080016 (is_implicated_in)
Disease	Amelogenesis imperfecta local hypoplastic form	LAMA3 RELT	3.94e-05	7	41	2	C0399367
Disease	sialic acid-binding Ig-like lectin 9 measurement	SIGLEC12 SIGLEC7	6.74e-05	9	41	2	EFO_0008286
Disease	myeloid cell surface antigen CD33 measurement	SIGLEC12 SIGLEC7	1.96e-04	15	41	2	EFO_0008238
Disease	urate measurement, bone density	FBLN1 EYS USH2A ZNF618 GLI2 AOAH	2.00e-04	619	41	6	EFO_0003923, EFO_0004531
Disease	blood cobalt measurement	EYS USH2A AOAH	3.78e-04	101	41	3	EFO_0007577
Disease	corneal topography	KANK4 ADAMTS20 FBN1	4.72e-04	109	41	3	EFO_0004345
Disease	retinitis pigmentosa (implicated_via_orthology)	EYS USH2A	6.47e-04	27	41	2	DOID:10584 (implicated_via_orthology)
Disease	stimulant use measurement	NCOA2 EYS	6.96e-04	28	41	2	EFO_0600076
Disease	IgA glomerulonephritis (is_implicated_in)	MTR PDE5A	7.99e-04	30	41	2	DOID:2986 (is_implicated_in)
Disease	refractive error	PTPN5 PDE5A FBN1 FBN3	1.07e-03	326	41	4	MONDO_0004892
Disease	waist-hip ratio	ADAMTS20 NID1 PDE5A SCUBE2 ADAMTSL3 VASN TMEM165	1.37e-03	1226	41	7	EFO_0004343

Protein segments in the cluster

Peptide	Gene	Start	Entry
SCGAICTNTIPTHEG	GVINP1	2291	Q7Z2Y8
THSGICGPGTCYNTL	FBN3	1611	Q75N90
TVTCGGGVQTRSVHC	ADAMTS18	1136	Q8TE60
GTPCGTETHDICVQG	ADAMTS20	676	P59510
CGQHLCTGIAGLDVT	ABCA7	1161	Q8IZY2
CGGSLEIVPCSRVGH	GALNT16	331	Q8N428
CPGTCSVQGGAHIST	MUC5B	421	Q9HC84
PIIVHCSAGIGRTGC	PTPN5	491	P54829
PIVVHCSAGIGRTGC	PTPN7	286	P35236
GQTISCPAHGCDILV	ARIH1	226	Q9Y4X5
SRPSLSNGHTCVGCV	AOAH	31	P28039
GGLCHESTIPGQFVC	EYS	821	Q5T1H1
SNGQLGSCHPLTGDC	LAMA3	1791	Q16787
LLSPCGCTGTLGAVH	MARCHF2	76	Q9P0N8
GIRGHTESCSCPLQQ	PDE5A	71	O76074
NGGCTHLCLATPGSR	NID1	1216	P14543
GCHICTSVTPGEPQV	KIF21B	26	O75037
GCLGHGSLTDISQPT	NEK8	421	Q86SG6
QVSGHGSCGCALPLS	GLI2	396	P10070
SAPCPIGHTCINTEG	FBLN1	316	P23142
IGTHCGQPVCESGCL	FBN1	141	P35555
PLLCRGGVCHNTEGS	FBN1	1121	P35555
HLTCEAGQGIPEGTC	KANK4	711	Q5T7N3
CHPQGSVGSSCSRLG	LAMB4	771	A4D0S4
STGVHCSCPVGFTLQ	SCUBE2	301	Q9NQ36
LACGDLQVTGSGHCP	CRMP1	321	Q14194
LQGFVGSTCPHICTV	FAM120B	6	Q96EK7
QACTSGGCLHSLPIT	USH2A	1221	O75445
ICCGTGVIGLSLAQH	TRMT2B	351	Q96GJ1
GLPECTRCGHGIVGT	PDLIM4	251	P50479
LVNIVGGCCGSTPDH	MTR	316	Q99707
HGTSLTCQVTLPGAG	SIGLEC7	211	Q9Y286
HGTSLTCQVTLPGAG	SIGLEC12	336	Q96PQ1
SGCVSATTLHPLGGQ	AKAP17A	476	Q02040
GSLHSPVGVCSSTGN	NCOA2	511	Q15596
CLGIGVTCHSQSVGP	ZNF618	546	Q5T7W0
EGCHICTSVTPGEPQ	KIF21A	26	Q7Z4S6
VGGTVGHCLCTGLAV	TMEM165	271	Q9HC07
PSTCLNGGTCHLGTR	VASN	411	Q6EMK4
LHTVQGLASLSGPCC	RELT	281	Q969Z4
ICGVPSQHGTEGCGR	ZBED9	626	Q6R2W3
CHTITGEQPSGCTGL	ZNF23	131	P17027
QTTCAVHSGSSGGPL	TYSND1	471	Q2T9J0
AGFTPCTATCVGGHQ	ADAMTSL3	651	P82987