Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	GTPase activator activity	DOCK2 SMAP1 ARHGAP32 TSC2 ARHGAP4 ARHGDIA BNIP2 TBC1D4 NF1 ARHGEF1	1.58e-05	279	131	10	GO:0005096
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	DOCK2 SMAP1 ARHGAP32 PLEKHG4 TSC2 EPS8L1 ARHGAP4 ARHGDIA BNIP2 TBC1D4 NF1 ARHGEF1	1.30e-04	507	131	12	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	DOCK2 SMAP1 ARHGAP32 PLEKHG4 TSC2 EPS8L1 ARHGAP4 ARHGDIA BNIP2 TBC1D4 NF1 ARHGEF1	1.30e-04	507	131	12	GO:0030695
GeneOntologyBiologicalProcess	neuron development	ARHGAP32 BLOC1S4 PLEKHG4 FZD3 WEE1 TNC TPRN CAMSAP3 OBSL1 CC2D1A TSC2 RUNX1 RETREG3 MAGI2 UNC5A ARHGAP4 NLGN3 NF1 ZNF296 MEGF8 PTPRS PTPRZ1 RP1L1 SLC4A10 ANKRD24 LGR6 SCRIB	3.55e-07	1463	130	27	GO:0048666
GeneOntologyBiologicalProcess	neuron projection development	ARHGAP32 BLOC1S4 PLEKHG4 FZD3 WEE1 TNC TPRN CAMSAP3 OBSL1 CC2D1A TSC2 RETREG3 MAGI2 UNC5A ARHGAP4 NLGN3 NF1 ZNF296 MEGF8 PTPRS PTPRZ1 ANKRD24 LGR6 SCRIB	1.45e-06	1285	130	24	GO:0031175
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	ARHGAP32 PLEKHG4 FZD3 TPRN OBSL1 CC2D1A TSC2 UNC5A ARHGAP4 NLGN3 MEGF8 PTPRS PTPRZ1 ANKRD24 LGR6 SCRIB	1.97e-05	748	130	16	GO:0048667
GeneOntologyBiologicalProcess	regulation of small GTPase mediated signal transduction	DOCK2 ARHGAP32 PLEKHG4 TSC2 EPS8L1 ARHGAP4 ARHGDIA BNIP2 NF1 ARHGEF1	5.06e-05	333	130	10	GO:0051056
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ARHGAP32 WEE1 CAMSAP3 LARP1 CC2D1A TSC2 CBARP RASSF7 TBC1D4 NF1 MEGF8 ARHGEF1 AHNAK RAB11FIP5 FIP1L1 BOD1L1 PROSER2 SCRIB BRD1	8.45e-10	861	133	19	36931259
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	WEE1 CAMSAP3 LARP1 RUNX1 RREB1 TRRAP KMT2D TBC1D4 NF1 MGMT CHTF18 POP1 FIP1L1 PLCB3 PROSER2 SCRIB	4.96e-08	774	133	16	15302935
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	FRAS1 DNAJA2 TRRAP KMT2D CDK5RAP3 NF1 CHTF18 ARHGEF1 POP1 FIP1L1 SCRIB	5.57e-07	410	133	11	26949251
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	SETD1B POLR1A PLEKHG4 DNAJA2 RUNX1 TRRAP ARHGDIA TBC1D4 NF1 AP2A2 CHTF18 ARHGEF1 AHNAK POP1 FIP1L1 SCRIB GMPPB DYNC1H1 ATP5F1B	1.02e-06	1353	133	19	29467282
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FRAS1 SETD1B ZNF316 CC2D1A TSC2 TRRAP RASSF7 SBNO2 KMT2D ZNF296 MEGF8 DOK4 PTPRS AHNAK DYNC1H1 TEX19 CREB3	1.17e-06	1105	133	17	35748872
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	WEE1 TPRN DNAJA2 PRSS56 ZNF316 OBSL1 RREB1 SP110 TRRAP ARHGAP4 ZFHX4 IL21R RAB11FIP5 FIP1L1 SCRIB BRD1 INO80B	1.34e-06	1116	133	17	31753913
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	LARP1 TSC2 NF1 PTPRS RAB11FIP5 FIP1L1 BOD1L1 SCRIB SNTB2	3.54e-06	313	133	9	38270169
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	LNX2 TNC LARP1 RASSF7 RETREG3 ARHGDIA CDK5RAP3 AP2A2 AHNAK FIP1L1 CREB3	4.01e-06	503	133	11	36217030
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	BCORL1 ZNF316 CAMSAP3 LARP1 TSC2 ZNF831 TBC1D4 AHNAK POP1 BOD1L1 PLCB3 SCRIB DYNC1H1	5.35e-06	736	133	13	29676528
Pubmed	DYRK3 phosphorylates SNAPIN to regulate axonal retrograde transport and neurotransmitter release.	DNAJA2 MAGI2 DYNC1H1	6.43e-06	10	133	3	36585413
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SETD1B POLR1A WEE1 LARP1 TRRAP NF1 CHTF18 POP1 FIP1L1 SCRIB	8.02e-06	440	133	10	34244565
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	SMAP1 ARHGAP32 TNC DNAJA2 CAMSAP3 LARP1 MAGI2 ARHGDIA NLGN3 NF1 AP2A2 PTPRS PTPRZ1 ARHGEF1 SLC4A10 SCRIB DYNC1H1 ATP5F1B	9.19e-06	1431	133	18	37142655
Pubmed	Quantifying domain-ligand affinities and specificities by high-throughput holdup assay.	LNX2 MAGI2 SCRIB SNTB2	1.09e-05	36	133	4	26053890
Pubmed	Cloning and characterization of a mouse homologue (mNthl1) of Escherichia coli endonuclease III.	NTHL1 TSC2	1.45e-05	2	133	2	9743625
Pubmed	Genetic Analysis of Human Chymotrypsin-Like Elastases 3A and 3B (CELA3A and CELA3B) to Assess the Role of Complex Formation between Proelastases and Procarboxypeptidases in Chronic Pancreatitis.	CELA3B CELA3A	1.45e-05	2	133	2	27999401
Pubmed	Neurofibromin interacts with the cytoplasmic Dynein Heavy Chain 1 in melanosomes of human melanocytes.	NF1 DYNC1H1	1.45e-05	2	133	2	23583712
Pubmed	Survival and tumorigenesis in O6-methylguanine DNA methyltransferase-deficient mice following cyclophosphamide exposure.	NF1 MGMT	1.45e-05	2	133	2	18477655
Pubmed	NF1 mutation drives neuronal activity-dependent initiation of optic glioma.	NLGN3 NF1	1.45e-05	2	133	2	34040258
Pubmed	Functional characterization of the promoter region of the human EVI1 gene in acute myeloid leukemia: RUNX1 and ELK1 directly regulate its transcription.	RUNX1 ELK1	1.45e-05	2	133	2	22689058
Pubmed	Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes.	CELA3B CELA3A	1.45e-05	2	133	2	2460440
Pubmed	The PDZ protein SCRIB regulates sodium/iodide symporter (NIS) expression at the basolateral plasma membrane.	SLC5A5 SCRIB	1.45e-05	2	133	2	34196428
Pubmed	Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning.	CELA3B CELA3A	1.45e-05	2	133	2	2826474
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	POLR1A GRWD1 NTHL1 TPRN OBSL1 LARP1 RRP1 AP2A2 AHNAK POP1 RAB11FIP5 FIP1L1 SCRIB DYNC1H1	1.75e-05	949	133	14	36574265
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DOCK2 ARHGAP32 TCAF1 PRX NLGN3 AP2A2 POP1 ANKRD24 N4BP1 MAML3	2.13e-05	493	133	10	15368895
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FRAS1 SETD1B OBSL1 MAGI2 UNC5A MEGF8 BOD1L1 SCRIB DYNC1H1	2.86e-05	407	133	9	12693553
Pubmed	Periaxin is required for hexagonal geometry and membrane organization of mature lens fibers.	PRX PTPRZ1 AHNAK	2.95e-05	16	133	3	21745462
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	SMAP1 TCAF1 GRWD1 DNAJA2 PRSS56 LARP1 CC2D1A TSC2 TBC1D4 AP2A2 CHTF18 ARHGEF1 AHNAK POP1 PLCB3 DYNC1H1 ATP5F1B	2.97e-05	1415	133	17	28515276
Pubmed	Functional specialization of beta-arrestin interactions revealed by proteomic analysis.	ARHGAP32 POLR1A WEE1 AP2A2 LRP11 RAB11FIP5 DYNC1H1 ATP5F1B	3.19e-05	317	133	8	17620599
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	BCORL1 CAMSAP3 RREB1 KMT2D TBC1D4 MID1IP1 ZFHX4 AHNAK BUB1	3.52e-05	418	133	9	34709266
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	TCAF1 GRWD1 DNAJA2 OBSL1 LARP1 TBC1D4 BUB1 SLC4A10 RAB11FIP5 ASPSCR1 SNTB2	3.69e-05	639	133	11	23443559
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	FRAS1 CAMSAP3 OBSL1 LARP1 SBNO2 CHTF18 ARHGEF1 BUB1 POP1 PLCB3 SCRIB	4.30e-05	650	133	11	38777146
Pubmed	Characterization of the activation of protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) by hypoxia inducible factor-2 alpha.	PTPRZ1 ELK1	4.34e-05	3	133	2	20224786
Pubmed	Self-regulated alternative splicing at the AHNAK locus.	PRX AHNAK	4.34e-05	3	133	2	21940993
Pubmed	The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription.	ZXDA CIITA	4.34e-05	3	133	2	17493635
Pubmed	Differential expression of micro-heterogeneous LewisX-type glycans in the stem cell compartment of the developing mouse spinal cord.	TNC PTPRZ1	4.34e-05	3	133	2	23624942
Pubmed	IL-21 Promotes Intestinal Memory IgA Responses.	IL21R IL17RA	4.34e-05	3	133	2	32859726
Pubmed	Glypican-1, phosphacan/receptor protein-tyrosine phosphatase-ζ/β and its ligand, tenascin-C, are expressed by neural stem cells and neural cells derived from embryonic stem cells.	TNC PTPRZ1	4.34e-05	3	133	2	20689858
Pubmed	A role for Dimethylarginine Dimethylaminohydrolase 1 (DDAH1) in mammalian development.	DDAH2 NF1	4.34e-05	3	133	2	19757398
Pubmed	Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes.	NTHL1 TSC2	4.34e-05	3	133	2	9831664
Pubmed	Detecting Low-Variant Allele Frequency Mosaic Pathogenic Variants of NF1, TSC2, and AKT3 Genes from Blood in Patients with Neurodevelopmental Disorders.	TSC2 NF1	4.34e-05	3	133	2	37088138
Pubmed	Concurrent Reduced Expression of Contiguous PKD1, TSC2 and NTHL1 Leading to Kidney Diseases and Multiple Diverse Renal Cancers.	NTHL1 TSC2	4.34e-05	3	133	2	36581342
Pubmed	Binding and inhibition of the ternary complex factor Elk-4/Sap1 by the adapter protein Dok-4.	DOK4 ELK1	4.34e-05	3	133	2	28275114
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	TPTE ARHGAP32 TPRN DNAJA2 CAMSAP3 CBARP KMT2D TBC1D4 PTPRS PTPRZ1 AHNAK RAB11FIP5 SCRIB SNTB2	5.19e-05	1049	133	14	27880917
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SETD1B RRP1 KMT2D AHNAK POP1 FIP1L1 BOD1L1	5.39e-05	251	133	7	31076518
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	WEE1 LARP1 TSC2 TBC1D4 RAB11FIP5 DYNC1H1 ATP5F1B	5.95e-05	255	133	7	15324660
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	TNC CAMSAP3 CBARP MAGI2 NF1 SLC4A10 RAB11FIP5 SNTB2	6.02e-05	347	133	8	17114649
Pubmed	Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.	NRGN DNAJA2 RUNX1 NFE2L1 AHNAK	6.73e-05	110	133	5	26841866
Pubmed	Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice.	TNC CELA3B CELA3A	6.91e-05	21	133	3	16518820
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	TCAF1 GRWD1 DNAJA2 TSC2 TBC1D4 AP2A2 ASPSCR1 SCRIB DYNC1H1 ATP5F1B	7.30e-05	571	133	10	37167062
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	SETD1B KMT2D BOD1L1	7.98e-05	22	133	3	26886794
Pubmed	RUNX represses Pmp22 to drive neurofibromagenesis.	RUNX1 NF1	8.67e-05	4	133	2	31032403
Pubmed	Endogenous N-terminal Domain Cleavage Modulates α1D-Adrenergic Receptor Pharmacodynamics.	SCRIB SNTB2	8.67e-05	4	133	2	27382054
Pubmed	The inv(3)(q21q26)/t(3;3)(q21;q26) is frequently accompanied by alterations of the RUNX1, KRAS and NRAS and NF1 genes and mediates adverse prognosis both in MDS and in AML: a study in 39 cases of MDS or AML.	RUNX1 NF1	8.67e-05	4	133	2	21283084
Pubmed	A novel anesthesia regime enables neurofunctional studies and imaging genetics across mouse strains.	TSC2 NLGN3	8.67e-05	4	133	2	27080031
Pubmed	A potential role for the OTX2 homeoprotein in creating early 'highways' for axon extension in the rostral brain.	TNC PTPRZ1	8.67e-05	4	133	2	9753681
Pubmed	Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma.	IL21R IL17RA	8.67e-05	4	133	2	20435882
Pubmed	Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene.	MAGI2 PTPRZ1	8.67e-05	4	133	2	17579610
Pubmed	Tenascin-C is an inhibitory boundary molecule in the developing olfactory bulb.	TNC PTPRZ1	8.67e-05	4	133	2	19641104
Pubmed	Coordinated regulation of protein synthesis and degradation by mTORC1.	TSC2 NFE2L1	8.67e-05	4	133	2	25043031
Pubmed	Overexpression of Nfe2l1 increases proteasome activity and delays vision loss in a preclinical model of human blindness.	TSC2 NFE2L1	8.67e-05	4	133	2	37450596
Pubmed	Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation.	IL21R IL17RA	8.67e-05	4	133	2	22177922
Pubmed	[Genetic susceptibility of single nucleotide polymorphism in MGMT to non-Hodgkin lymphoma].	XPA MGMT	8.67e-05	4	133	2	19954624
Pubmed	The cytokine midkine and its receptor RPTPζ regulate B cell survival in a pathway induced by CD74.	PTPRS PTPRZ1	8.67e-05	4	133	2	22140262
Pubmed	Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals.	FZD3 SCRIB	8.67e-05	4	133	2	16687519
Pubmed	Comprehensive identification of human bZIP interactions with coiled-coil arrays.	TEF NFE2L1 CREB3	9.15e-05	23	133	3	12805554
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	ARHGAP32 LARP1 CC2D1A ARHGDIA CDK5RAP3 AHNAK RAB11FIP5 BOD1L1 SCRIB DYNC1H1 ATP5F1B	9.20e-05	708	133	11	39231216
Pubmed	Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.	WEE1 LARP1 TSC2 TBC1D4 DYNC1H1 ATP5F1B	9.48e-05	190	133	6	15161933
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	ARHGAP32 CAMSAP3 NLGN3 NF1 AP2A2 AHNAK DYNC1H1	1.09e-04	281	133	7	28706196
Pubmed	An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity.	DNAJA2 SCRIB SNTB2	1.18e-04	25	133	3	37589075
Pubmed	The tale of the long tail: the cytoplasmic domain of HIV-1 gp41.	AP2A2 ARHGEF1 CREB3	1.33e-04	26	133	3	23077317
Pubmed	Phosphacan short isoform, a novel non-proteoglycan variant of phosphacan/receptor protein tyrosine phosphatase-beta, interacts with neuronal receptors and promotes neurite outgrowth.	TNC PTPRZ1	1.44e-04	5	133	2	12700241
Pubmed	Regulation of the murine Ddelta2 promoter by upstream stimulatory factor 1, Runx1, and c-Myb.	RUNX1 NF1	1.44e-04	5	133	2	15778374
Pubmed	Contribution of the Runx1 transcription factor to axonal pathfinding and muscle innervation by hypoglossal motoneurons.	FZD3 RUNX1	1.44e-04	5	133	2	25762373
Pubmed	The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract.	XPA MGMT	1.44e-04	5	133	2	17040931
Pubmed	Differential expression of phosphacan/RPTPbeta isoforms in the developing mouse visual system.	TNC PTPRZ1	1.44e-04	5	133	2	17722031
Pubmed	Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.	CELA3B CELA3A	1.44e-04	5	133	2	27358403
Pubmed	Multiple signals regulate axon regeneration through the Nogo receptor complex.	ARHGDIA ARHGEF1	1.44e-04	5	133	2	16215275
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	DNAJA2 LARP1 ARHGDIA TBC1D4 AHNAK BOD1L1 PROSER2 SCRIB	1.58e-04	399	133	8	35987950
Pubmed	Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.	WEE1 RUNX1 KMT2D NF1	1.63e-04	71	133	4	28319113
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	TCAF1 POLR1A OBSL1 TSC2 TRRAP INO80B ATP5F1B	1.63e-04	300	133	7	28561026
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ARHGAP32 WEE1 TNC BCORL1 KMT2D NF1 MEGF8 RAB11FIP5 MAML3 SNTB2	1.80e-04	638	133	10	31182584
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	COL4A6 LGMN FRAS1 FAM234A FKRP SPCS1 TSC2 TBC1D4 NF1 MEGF8 PTPRS LRP11 SCRIB ATP5F1B	2.14e-04	1201	133	14	35696571
Pubmed	GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi's Sarcoma-Associated Herpesvirus-Induced Cellular Transformation.	GRWD1 KMT2D	2.16e-04	6	133	2	34933446
Pubmed	Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene.	RUNX1 ELK1	2.16e-04	6	133	2	14970218
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	FRAS1 GRWD1 WEE1 LARP1 AP2A2 CHTF18 POP1 FIP1L1 LGR6 SCRIB	2.17e-04	653	133	10	33742100
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	FAM234A TCAF1 POLR1A FKRP DNAJA2 OBSL1 TSC2 RRP1 RETREG3 ARHGEF1 SCRIB DYNC1H1	2.78e-04	942	133	12	31073040
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	POLR1A WEE1 TBC1D4 NFE2L1 DYNC1H1 ATP5F1B	2.80e-04	232	133	6	25515538
Pubmed	HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.	SP110 TRRAP DYNC1H1	3.00e-04	34	133	3	25925205
Pubmed	The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake.	TSC2 TBC1D4	3.01e-04	7	133	2	18511518
Pubmed	Genome-Wide Analysis in Brazilians Reveals Highly Differentiated Native American Genome Regions.	DOCK2 CIITA	3.01e-04	7	133	2	28100790
Pubmed	Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype.	RUNX1 NF1	3.01e-04	7	133	2	19144660
Pubmed	Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules.	SCRIB SNTB2	3.01e-04	7	133	2	26617989
Pubmed	Genome wide molecular analysis of minimally differentiated acute myeloid leukemia.	RUNX1 NF1	3.01e-04	7	133	2	19773259
Pubmed	Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.	TSC2 NF1	3.01e-04	7	133	2	21896734
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	DOCK2 GRWD1 BCORL1 ZNF316 LARP1 CC2D1A RUNX1 RREB1 TRRAP ARHGDIA KMT2D FIP1L1 DYNC1H1	3.26e-04	1103	133	13	34189442
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ARHGAP32 TCAF1 DNAJA2 CAMSAP3 TSC2 MAGI2 NLGN3 NF1 AP2A2 PTPRS SCRIB DYNC1H1	3.40e-04	963	133	12	28671696
Pubmed	Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.	DDAH2 TNC DNAJA2 MAGI2 PTPRZ1 SLC4A10 CARNS1	3.55e-04	341	133	7	29791485
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	LGMN DNAJA2 TRRAP AP2A2 GMPPB DYNC1H1 ATP5F1B	3.74e-04	344	133	7	30333137
Pubmed	Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress.	POLR1A RRP1 ARHGAP4 POP1 ATP5F1B	3.76e-04	159	133	5	22751105
Pubmed	p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.	TNC AP2A2 AHNAK SNTB2 ATP5F1B	3.76e-04	159	133	5	30581152
GeneFamily	PDZ domain containing	LNX2 PRX MAGI2 AHNAK SCRIB SNTB2	6.62e-05	152	82	6	1220
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNC CAMSAP3 EPS8L1 RASSF7 MAGI2 ZFHX4 PTPRZ1	1.19e-06	180	133	7	da723df348d7b8449bb1124f23fe6fa706412adb
ToppCell	droplet-Heart-nan-3m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNC CAMSAP3 EPS8L1 RASSF7 MAGI2 ZFHX4 PTPRZ1	1.19e-06	180	133	7	5b146a94708b3c3610542a4d0925f3f7a2b19185
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNC CAMSAP3 EPS8L1 RASSF7 MAGI2 ZFHX4 PTPRZ1	1.19e-06	180	133	7	50758b1e7be2e43f83c10ab106900c067e61f5f7
ToppCell	droplet-Pancreas-Exocrine-21m-Epithelial-pancreatic_ductal_cel\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A6 SAMD5 VIT PRX SLC5A5 CFAP221	1.31e-05	172	133	6	c0bda7153e02bee7d0326138cc684151c404c2a1
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A6 FRAS1 C2orf72 MAGI2 CFAP221 PROSER2	1.75e-05	181	133	6	9d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A6 FRAS1 C2orf72 MAGI2 CFAP221 PROSER2	1.81e-05	182	133	6	eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCell	E17.5-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FRAS1 EPS8L1 TEF RASSF7 FADS3 AHNAK	2.30e-05	190	133	6	15f314517ed47b12d287a12a7d18cb383310e25a
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-leukocyte\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RUNX1 RASSF7 CILP2 PTPRZ1 IL21R LGR6	2.37e-05	191	133	6	116fba9badea093e11f370996247cca0e4c02e8f
ToppCell	Parenchymal-NucSeq-Stromal-Mesofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FRAS1 CBARP ZXDA ZFHX4 PTPRZ1 CARNS1	2.67e-05	195	133	6	a52685f76eca269a7d2de8dfc317439483e233fa
ToppCell	Parenchymal-NucSeq-Stromal-Mesofibroblastic-Mesothelia\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FRAS1 CBARP ZXDA ZFHX4 PTPRZ1 CARNS1	2.67e-05	195	133	6	224deeba2f60def6543a55bb4f5ee6c7fdab3f02
ToppCell	facs-Bladder-nan-3m\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A6 TEF AP2A2 PTPRS AHNAK DYNC1H1	2.74e-05	196	133	6	44f5b1b474399c9316729155f2ea95a82ca66e30
ToppCell	facs-Bladder-nan-3m-Epithelial\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A6 TEF AP2A2 PTPRS AHNAK DYNC1H1	2.74e-05	196	133	6	c0e90d964baa2eb4fbd18a52379ccec5d3bf59a8
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	WEE1 TNC XPA FADS3 LGR6 CARNS1	2.82e-05	197	133	6	470e23dee4ca35e1fd021b7cdd58fcbc90639837
ToppCell	Skin-Mesangial\|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.	DCHS2 NRGN ZXDA FADS3 MID1IP1 ANKRD24	2.99e-05	199	133	6	bcb78838a91cc7828680fb413fbacdb091c5fac0
Drug	Pivmecillinam hydrochloride [32887-03-9]; Down 200; 8.4uM; PC3; HT_HG-U133A	TNC CC2D1A RUNX1 FADS3 NF1 PLCB3 N4BP1 BRD1 QRSL1	2.07e-06	196	131	9	7312_DN
Drug	U-62066 [87151-85-7]; Down 200; 1uM; PC3; HT_HG-U133A	COL4A6 FKRP EPS8L1 RUNX1 SBNO2 CISH MEGF8 PTPRS N4BP1	2.16e-06	197	131	9	3818_DN
Drug	Amrinone [60719-84-8]; Down 200; 21.4uM; HL60; HT_HG-U133A	ARHGAP32 NRGN BCORL1 RUNX1 SP110 SBNO2 ELK1 PLCB3 DGCR8	2.25e-06	198	131	9	2724_DN
Drug	Flunarizine dihydrochloride [30484-77-6]; Down 200; 8.4uM; MCF7; HT_HG-U133A	NRGN WEE1 BCORL1 EPS8L1 NF1 ELK1 PLCB3 DGCR8 INO80B	2.25e-06	198	131	9	7412_DN
Drug	Isoxsuprine hydrochloride [579-56-6]; Up 200; 11.8uM; HL60; HG-U133A	MGAM NRGN BCORL1 OBSL1 SBNO2 ARHGAP4 TRANK1 NF1 CREB3	2.25e-06	198	131	9	1985_UP
Drug	Riluzole hydrochloride; Down 200; 14.8uM; PC3; HT_HG-U133A	ARHGAP32 EPS8L1 RUNX1 SP110 RASSF7 BUB1 PLCB3 DGCR8 INO80B	2.34e-06	199	131	9	7365_DN
Drug	Ozagrel hydrochloride [78712-43-3]; Down 200; 15.2uM; PC3; HT_HG-U133A	ARHGAP32 GRWD1 TNC FADS3 AP2A2 FIP1L1 PLCB3 N4BP1 BRD1	2.34e-06	199	131	9	7281_DN
Drug	Buspirone hydrochloride [33386-08-2]; Down 200; 9.4uM; HL60; HT_HG-U133A	GRWD1 NRGN EPS8L1 MGMT FCGRT ARHGEF1 FIP1L1 ELK1 DGCR8	2.44e-06	200	131	9	1282_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	TPTE SETD1B EPS8L1 RUNX1 SBNO2 ASPSCR1 DGCR8 BRD1	9.10e-06	178	131	8	1471_DN
Drug	Etofenamate [30544-47-9]; Up 200; 10.8uM; PC3; HT_HG-U133A	COL4A6 DCHS2 OBSL1 EPS8L1 RUNX1 ARHGAP4 KMT2D INO80B	1.64e-05	193	131	8	3989_UP
Drug	0317956-0000 [391210-11-0]; Down 200; 10uM; PC3; HT_HG-U133A	TSC2 SBNO2 FADS3 NF1 ARHGEF1 BUB1 ELK1 INO80B	1.70e-05	194	131	8	4331_DN
Drug	Alexidine dihydrochloride [22573-93-9]; Down 200; 6.8uM; MCF7; HT_HG-U133A	GRWD1 CC2D1A AP2A2 DOK4 ELK1 PLCB3 IL17RA INO80B	1.70e-05	194	131	8	4721_DN
Drug	Androsterone [53-41-8]; Down 200; 13.8uM; HL60; HT_HG-U133A	NRGN LARP1 RUNX1 CISH MGMT AP2A2 POP1 SCRIB	1.77e-05	195	131	8	1296_DN
Drug	Isoniazid [54-85-3]; Down 200; 29.2uM; PC3; HT_HG-U133A	ARHGAP32 BCORL1 EPS8L1 RUNX1 MGMT N4BP1 QRSL1 INO80B	1.77e-05	195	131	8	5840_DN
Drug	haloperidol; Down 200; 10uM; MCF7; HT_HG-U133A	NRGN TNC ZNF446 SLC5A5 MAGI2 CD1A DOK4 INO80B	1.83e-05	196	131	8	5604_DN
Drug	Aminopurine, 6-benzyl [1214-39-7]; Down 200; 17.8uM; PC3; HT_HG-U133A	COL4A6 EPS8L1 ZNF446 NF1 AP2A2 BUB1 N4BP1 DGCR8	1.83e-05	196	131	8	3726_DN
Drug	Antazoline hydrochloride [2508-72-7]; Down 200; 13.2uM; MCF7; HT_HG-U133A	EPS8L1 RUNX1 FADS3 AP2A2 DOK4 FIP1L1 PLCB3 ASPSCR1	1.83e-05	196	131	8	6775_DN
Drug	Midodrine hydrochloride [3092-17-9]; Up 200; 13.8uM; MCF7; HT_HG-U133A	DCHS2 FRAS1 FKRP EPS8L1 RUNX1 PRX NF1 AHNAK	1.83e-05	196	131	8	2250_UP
Drug	Propafenone hydrochloride [34183-22-7]; Down 200; 10.6uM; MCF7; HT_HG-U133A	SP110 ZNF446 SLC5A5 TBC1D4 DOK4 ELK1 IL17RA DGCR8	1.90e-05	197	131	8	5437_DN
Drug	0393-0188; Down 200; 10uM; PC3; HT_HG-U133A	FZD3 TNC CISH TBC1D4 NF1 BUB1 POP1 QRSL1	1.90e-05	197	131	8	7510_DN
Drug	3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Down 200; 13.8uM; HL60; HT_HG-U133A	EPS8L1 RUNX1 SBNO2 SLC5A5 AP2A2 MEGF8 PTPRS RAB11FIP5	1.90e-05	197	131	8	2204_DN
Drug	genistein; Down 200; 10uM; MCF7; HT_HG-U133A	BCORL1 CC2D1A EPS8L1 SP110 FANCE FADS3 NF1 ELK1	1.90e-05	197	131	8	6952_DN
Drug	Vitamin K2 [11032-49-8]; Down 200; 9uM; MCF7; HT_HG-U133A	NRGN TNC RUNX1 CD1A TBC1D4 NF1 DOK4 PTPRS	1.97e-05	198	131	8	3880_DN
Drug	Norcyclobenzaprine [303-50-4]; Up 200; 15.4uM; HL60; HT_HG-U133A	OBSL1 EPS8L1 RUNX1 SBNO2 SLC5A5 FADS3 PTPRS INO80B	2.04e-05	199	131	8	2469_UP
Drug	estradiol; Down 200; 0.01uM; PC3; HT_HG-U133A	EPS8L1 RUNX1 SP110 TRANK1 NF1 DOK4 ASPSCR1 DGCR8	2.04e-05	199	131	8	5960_DN
Drug	Azathioprine [446-86-6]; Down 200; 14.4uM; PC3; HG-U133A	SETD1B NRGN OBSL1 CC2D1A RETREG3 SLC5A5 MID1IP1 DGCR8	2.04e-05	199	131	8	1945_DN
Drug	A-39	TEF FCGRT	3.29e-05	2	131	2	CID003024589
Drug	2-iminothiolane	ARHGAP32 TNC FCGRT	3.94e-05	12	131	3	CID000433941
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SETD1B LARP1 EPS8L1 RUNX1 CISH ASPSCR1 DGCR8	6.09e-05	171	131	7	4954_DN
Drug	SAHA; Down 200; 10uM; MCF7; HT_HG-U133A	SETD1B LARP1 EPS8L1 SBNO2 MID1IP1 ASPSCR1 DGCR8	6.80e-05	174	131	7	5580_DN
Drug	3-chlorophenol	MGAM ARHGAP32 CISH	8.05e-05	15	131	3	CID000007933
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	TPTE SETD1B LARP1 EPS8L1 RUNX1 CISH DGCR8	8.41e-05	180	131	7	5511_DN
Drug	Dobutamine hydrochloride [49745-95-1]; Up 200; 11.8uM; PC3; HT_HG-U133A	TNC TRANK1 NF1 ARHGEF1 PLCB3 N4BP1 DGCR8	9.98e-05	185	131	7	6286_UP
Drug	2-propylpentanoic acid; Down 200; 10000uM; MCF7; HG-U133A	SETD1B GRWD1 OBSL1 EPS8L1 RUNX1 SBNO2 N4BP1	1.10e-04	188	131	7	345_DN
Drug	2-propylpentanoic acid; Up 200; 10000uM; HL60; HG-U133A	NRGN RASSF7 CD1A FIP1L1 N4BP1 SNTB2 CREB3	1.18e-04	190	131	7	410_UP
Drug	Rolipram [61413-54-5]; Up 200; 14.6uM; PC3; HT_HG-U133A	DCHS2 FKRP RUNX1 TEF KMT2D NF1 AP2A2	1.30e-04	193	131	7	6730_UP
Drug	Captopril [62571-86-2]; Up 200; 17.2uM; HL60; HG-U133A	MGAM RUNX1 SBNO2 ARHGAP4 TBC1D4 NFE2L1 DGCR8	1.30e-04	193	131	7	1988_UP
Drug	Tocainide hydrochloride; Up 200; 17.4uM; MCF7; HT_HG-U133A	OBSL1 CC2D1A TRRAP DOK4 ASPSCR1 IL17RA DGCR8	1.34e-04	194	131	7	4838_UP
Drug	SC 19220; Up 200; 10uM; PC3; HT_HG-U133A	EPS8L1 RUNX1 ZNF446 CISH PLCB3 ASPSCR1 DGCR8	1.34e-04	194	131	7	7065_UP
Drug	Ipratropium bromide [22254-24-6]; Up 200; 9.8uM; HL60; HG-U133A	CC2D1A EPS8L1 SBNO2 RRP1 ARHGAP4 DGCR8 SNTB2	1.34e-04	194	131	7	1769_UP
Drug	Gabexate mesilate [56974-61-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A	NRGN NTHL1 EPS8L1 RASSF7 ZNF446 SBNO2 AP2A2	1.34e-04	194	131	7	4804_DN
Drug	Naproxen [22204-53-1]; Down 200; 17.4uM; MCF7; HT_HG-U133A	RUNX1 ZNF446 NF1 DOK4 RAB11FIP5 DGCR8 INO80B	1.34e-04	194	131	7	5457_DN
Drug	Dobutamine hydrochloride [49745-95-1]; Up 200; 11.8uM; MCF7; HT_HG-U133A	RUNX1 C2orf72 ARHGAP4 NF1 MEGF8 PLCB3 IL17RA	1.38e-04	195	131	7	5386_UP
Drug	PF-00539745-00 [351321-33-0]; Down 200; 10uM; PC3; HT_HG-U133A	CBARP EPS8L1 RUNX1 ZNF446 PTPRS ASPSCR1 DGCR8	1.38e-04	195	131	7	5979_DN
Drug	Tranexamic acid [1197-18-8]; Down 200; 25.4uM; HL60; HG-U133A	NRGN BCORL1 EPS8L1 SLC5A5 ELK1 N4BP1 IL17RA	1.38e-04	195	131	7	1401_DN
Drug	Fenoprofen calcium salt dihydrate [53746-45-5]; Down 200; 7.2uM; PC3; HT_HG-U133A	SETD1B SBNO2 CISH BUB1 ELK1 IL17RA DGCR8	1.38e-04	195	131	7	3714_DN
Drug	GSK-3 Inhibitor IX; Up 200; 0.5uM; PC3; HT_HG-U133A	RUNX1 CISH NF1 AP2A2 ELK1 PLCB3 INO80B	1.38e-04	195	131	7	7106_UP
Drug	0179445-0000 [211246-22-9]; Down 200; 1uM; PC3; HT_HG-U133A	COL4A6 LARP1 RUNX1 ASPSCR1 N4BP1 DGCR8 INO80B	1.43e-04	196	131	7	4292_DN
Drug	Pantothenic acid calcium salt monohydrate [63409-48-3]; Down 200; 8uM; MCF7; HT_HG-U133A	WEE1 CC2D1A EPS8L1 RASSF7 ZNF446 ASPSCR1 IL17RA	1.43e-04	196	131	7	4775_DN
Drug	Benzonatate [104-31-4]; Down 200; 6.6uM; MCF7; HT_HG-U133A	RUNX1 ZNF446 FANCE NF1 DOK4 DGCR8 INO80B	1.43e-04	196	131	7	5435_DN
Drug	Mafenide hydrochloride [138-37-4]; Down 200; 18uM; MCF7; HT_HG-U133A	RUNX1 SBNO2 FADS3 NF1 BUB1 QRSL1 INO80B	1.43e-04	196	131	7	5499_DN
Drug	Terconazole [67915-31-5]; Up 200; 7.6uM; HL60; HT_HG-U133A	EPS8L1 RUNX1 TEF ZNF446 PRX SBNO2 MAML3	1.43e-04	196	131	7	2484_UP
Drug	valinomycin; Down 200; 0.1uM; PC3; HT_HG-U133A	COL4A6 SP110 TRANK1 DOK4 IL21R DGCR8 INO80B	1.43e-04	196	131	7	5962_DN
Drug	Sulfaguanidine [57-67-0]; Up 200; 18.6uM; PC3; HG-U133A	BCORL1 OBSL1 EPS8L1 SLC5A5 FANCE ELK1 N4BP1	1.43e-04	196	131	7	1913_UP
Drug	Rauwolscine hydrochloride [6211-32-1]; Up 200; 10.2uM; MCF7; HT_HG-U133A	NRGN TNC RUNX1 TEF NF1 ZFHX4 DOK4	1.43e-04	196	131	7	2778_UP
Drug	Trifluridine [70-00-8]; Down 200; 13.6uM; PC3; HT_HG-U133A	COL4A6 EPS8L1 SP110 SBNO2 FADS3 PLCB3 N4BP1	1.47e-04	197	131	7	5819_DN
Drug	Pirlindole mesylate [60762-57-4]; Down 200; 12.4uM; MCF7; HT_HG-U133A	BCORL1 RUNX1 ARHGAP4 NF1 RAB11FIP5 ASPSCR1 IL17RA	1.47e-04	197	131	7	6519_DN
Drug	Diazoxide [364-98-7]; Down 200; 17.4uM; HL60; HG-U133A	SETD1B XPA ARHGAP4 NF1 MID1IP1 AP2A2 NFE2L1	1.47e-04	197	131	7	1368_DN
Drug	Meptazinol hydrochloride [59263-76-2]; Down 200; 14.8uM; MCF7; HT_HG-U133A	ARHGAP32 NTHL1 LARP1 TSC2 PLCB3 ASPSCR1 INO80B	1.47e-04	197	131	7	4774_DN
Drug	Trichlorfon [52-68-6]; Down 200; 15.6uM; PC3; HT_HG-U133A	COL4A6 ARHGAP32 NF1 AP2A2 FIP1L1 N4BP1 BRD1	1.47e-04	197	131	7	7287_DN
Drug	ICI182,780; Up 200; 1uM; PC3; HT_HG-U133A	COL4A6 TNC RUNX1 MEGF8 ELK1 PLCB3 N4BP1	1.47e-04	197	131	7	6867_UP
Drug	2-propylpentanoic acid; Down 200; 50uM; MCF7; HT_HG-U133A	SETD1B NRGN EPS8L1 SP110 FANCE FADS3 BUB1	1.47e-04	197	131	7	6941_DN
Drug	PF-00539745-00 [351321-33-0]; Up 200; 10uM; PC3; HT_HG-U133A	FZD3 BCORL1 RUNX1 ZNF446 AP2A2 ASPSCR1 DGCR8	1.47e-04	197	131	7	5939_UP
Drug	Pimozide [2062-78-4]; Down 200; 8.6uM; PC3; HT_HG-U133A	COL4A6 GRWD1 FANCE FADS3 NF1 AP2A2 QRSL1	1.47e-04	197	131	7	7132_DN
Drug	Gemfibrozil [25812-30-0]; Up 200; 16uM; PC3; HT_HG-U133A	CBARP RUNX1 PRX MEGF8 DOK4 PTPRS ELK1	1.47e-04	197	131	7	5069_UP
Drug	Furosemide [54-31-9]; Down 200; 12uM; PC3; HT_HG-U133A	TSC2 RUNX1 SBNO2 CISH PTPRS AHNAK DGCR8	1.47e-04	197	131	7	4503_DN
Drug	Clorgyline hydrochloride [17780-75-5]; Down 200; 13uM; HL60; HG-U133A	TRRAP CISH ARHGAP4 TBC1D4 NF1 RAB11FIP5 N4BP1	1.47e-04	197	131	7	1604_DN
Drug	Ungerine nitrate; Down 200; 10.2uM; HL60; HT_HG-U133A	GRWD1 RUNX1 SBNO2 AP2A2 ELK1 ASPSCR1 INO80B	1.47e-04	197	131	7	2514_DN
Drug	Fluorocurarine chloride [22273-09-2]; Up 200; 11.6uM; MCF7; HT_HG-U133A	RUNX1 TEF SBNO2 NF1 AP2A2 ELK1 ASPSCR1	1.47e-04	197	131	7	6219_UP
Drug	Mephenesin [59-47-2]; Down 200; 22uM; PC3; HT_HG-U133A	EPS8L1 RUNX1 RASSF7 SBNO2 FADS3 ELK1 DGCR8	1.47e-04	197	131	7	7374_DN
Drug	Ampyrone [83-07-8]; Up 200; 19.6uM; PC3; HT_HG-U133A	RUNX1 SP110 ZNF446 AP2A2 DOK4 ASPSCR1 DGCR8	1.47e-04	197	131	7	4507_UP
Drug	Trimeprazine tartrate [4330-99-8]; Down 200; 5.4uM; MCF7; HT_HG-U133A	CC2D1A EPS8L1 SBNO2 FADS3 ELK1 PLCB3 INO80B	1.47e-04	197	131	7	3478_DN
Drug	Dihydrostreptomycin sulfate [5490-27-7]; Up 200; 2.8uM; PC3; HT_HG-U133A	EPS8L1 NF1 AP2A2 MEGF8 AHNAK BUB1 DGCR8	1.47e-04	197	131	7	5751_UP
Drug	Cefalonium [5575-21-3]; Up 200; 8.8uM; PC3; HT_HG-U133A	COL4A6 EPS8L1 RUNX1 CD1A NF1 AHNAK N4BP1	1.47e-04	197	131	7	4245_UP
Drug	Lisinopril [83915-83-7]; Down 200; 9uM; HL60; HT_HG-U133A	BCORL1 EPS8L1 RASSF7 ELK1 ASPSCR1 N4BP1 INO80B	1.47e-04	197	131	7	2371_DN
Drug	Nafcillin sodium salt monohydrate [7177-50-6]; Up 200; 8.8uM; MCF7; HT_HG-U133A	TNC RUNX1 NF1 PTPRS ARHGEF1 AHNAK PLCB3	1.52e-04	198	131	7	3323_UP
Drug	Ketanserin tartrate hydrate [83846-83-7]; Down 200; 7uM; MCF7; HT_HG-U133A	WEE1 CC2D1A SP110 RRP1 NF1 BUB1 INO80B	1.52e-04	198	131	7	4995_DN
Drug	Diethylstilbestrol [56-53-1]; Down 200; 15uM; MCF7; HT_HG-U133A	FKRP TNC NF1 DOK4 PTPRS N4BP1 DGCR8	1.52e-04	198	131	7	3895_DN
Drug	Dacarbazine [4342-03-4]; Up 200; 22uM; HL60; HG-U133A	CC2D1A XPA RUNX1 FADS3 ELK1 N4BP1 DGCR8	1.52e-04	198	131	7	1762_UP
Drug	Antimycin A [1397-94-0]; Up 200; 7.2uM; PC3; HT_HG-U133A	COL4A6 DCHS2 EPS8L1 TRANK1 MEGF8 DOK4 PTPRS	1.52e-04	198	131	7	5053_UP
Drug	Methoxamine hydrochloride [61-16-5]; Up 200; 16.2uM; MCF7; HT_HG-U133A	FKRP ZNF446 SLC5A5 FADS3 MID1IP1 ZFHX4 N4BP1	1.52e-04	198	131	7	2848_UP
Drug	Hemicholinium bromide [312-45-8]; Down 200; 7uM; HL60; HG-U133A	SETD1B WEE1 XPA CISH MID1IP1 NFE2L1 ELK1	1.52e-04	198	131	7	1601_DN
Drug	ICI 182,780; Up 200; 0.01uM; HL60; HT_HG-U133A	WEE1 BCORL1 EPS8L1 TBC1D4 NF1 ARHGEF1 INO80B	1.57e-04	199	131	7	1179_UP
Drug	Karakoline [39089-30-0]; Down 200; 10.6uM; PC3; HT_HG-U133A	ZNF446 CISH PTPRS BUB1 N4BP1 DGCR8 INO80B	1.57e-04	199	131	7	3741_DN
Drug	Zalcitabine [7481-89-2]; Down 200; 19uM; MCF7; HT_HG-U133A	CISH NF1 AP2A2 ASPSCR1 N4BP1 IL17RA INO80B	1.57e-04	199	131	7	4799_DN
Drug	Acetaminophen [103-90-2]; Up 200; 26.4uM; MCF7; HT_HG-U133A	SETD1B TNC RUNX1 ZNF446 ARHGAP4 NF1 PLCB3	1.57e-04	199	131	7	5384_UP
Drug	Sulfasalazine [599-79-1]; Up 200; 10uM; MCF7; HT_HG-U133A	BCORL1 RUNX1 NF1 ZFHX4 AP2A2 BUB1 DGCR8	1.57e-04	199	131	7	2882_UP
Drug	sodium 4-phenylbutyrate; Down 200; 1000uM; MCF7; HG-U133A	ARHGAP32 GRWD1 RUNX1 SBNO2 C2orf72 FANCE CIITA	1.57e-04	199	131	7	408_DN
Drug	chlorpromazine hydrochloride; Down 200; 1uM; MCF7; HT_HG-U133A	EPS8L1 SBNO2 FANCE TBC1D4 FADS3 NF1 ELK1	1.57e-04	199	131	7	6936_DN
Drug	Dropropizine (R,S) [17692-31-8]; Up 200; 17uM; MCF7; HT_HG-U133A	EPS8L1 SLC5A5 FADS3 NF1 DOK4 RAB11FIP5 N4BP1	1.57e-04	199	131	7	7429_UP
Drug	Aconitine [302-27-2]; Up 200; 6.2uM; HL60; HG-U133A	OBSL1 EPS8L1 RRP1 PCSK1N DGCR8 SNTB2 CREB3	1.57e-04	199	131	7	1784_UP
Drug	Hydrochlorothiazide [58-93-5]; Up 200; 13.4uM; HL60; HG-U133A	MGAM NRGN WEE1 RASSF7 ARHGAP4 FCGRT ASPSCR1	1.57e-04	199	131	7	1987_UP
Drug	Crotamiton [483-63-6]; Up 200; 19.6uM; PC3; HT_HG-U133A	LCAT RUNX1 MAGI2 KMT2D NF1 AP2A2 ASPSCR1	1.57e-04	199	131	7	4628_UP
Drug	wortmannin from Penicillium funiculosum; Down 200; 0.01uM; MCF7; HT_HG-U133A	GRWD1 TNC FANCE MAGI2 DOK4 PTPRS RAB11FIP5	1.62e-04	200	131	7	5603_DN
Drug	Pivmecillinam hydrochloride [32887-03-9]; Up 200; 8.4uM; HL60; HT_HG-U133A	EPS8L1 LCAT RUNX1 SLC5A5 MAGI2 TBC1D4 INO80B	1.62e-04	200	131	7	2973_UP
Drug	wortmannin from Penicillium funiculosum; Down 200; 0.01uM; MCF7; HT_HG-U133A	GRWD1 NRGN CC2D1A EPS8L1 SBNO2 DOK4 ASPSCR1	1.62e-04	200	131	7	7002_DN
Drug	nickel disulfide	TEF SLC5A5 MGMT	1.69e-04	19	131	3	CID000518481
Drug	AC1Q4I5I	CELA3B CELA3A	1.96e-04	4	131	2	CID000194288
Drug	naphtho[2,1-b]thiophene	MGAM NTHL1	1.96e-04	4	131	2	CID000067474
Drug	AC1NR9O8	MGAM NLGN3 ELK1 ASPSCR1	2.29e-04	52	131	4	CID005287428
Disease	Adenoid Cystic Carcinoma	BCORL1 MAGI2 PCSK1N BRD1 MAML3	8.27e-05	100	130	5	C0010606
Disease	migraine disorder, type 2 diabetes mellitus	WEE1 RREB1 SLC4A10 CREB3	1.45e-04	60	130	4	MONDO_0005148, MONDO_0005277
Disease	alkaline phosphatase measurement	KCP TSC2 RUNX1 RREB1 SBNO2 CILP2 CELA3A TRANK1 FADS3 NF1 MGMT FCGRT AHNAK RP1L1	1.60e-04	1015	130	14	EFO_0004533
Disease	Qualitative or quantitative defects of alpha-dystroglycan	FKRP GMPPB	2.86e-04	6	130	2	cv:C2936406
Disease	level of Phosphatidylcholine (16:0_20:5) in blood serum	FADS3 AHNAK	6.80e-04	9	130	2	OBA_2045077
Disease	level of Phosphatidylcholine (18:0_20:5) in blood serum	FADS3 AHNAK	6.80e-04	9	130	2	OBA_2045095
Disease	Cutaneous Melanoma	XPA TRRAP NF1	7.88e-04	41	130	3	C0151779
Disease	melanoma	TNC XPA ZNF831 TRRAP SLC5A5 NF1	8.31e-04	248	130	6	C0025202
Disease	MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO (finding)	SP110 CISH	8.47e-04	10	130	2	C1834752
Disease	Mycobacterium tuberculosis, susceptibility to	SP110 CISH	8.47e-04	10	130	2	cv:C1834752
Disease	MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO	SP110 CISH	8.47e-04	10	130	2	607948
Disease	subiculum volume	SAMD5 LRP11 SLC4A10	9.07e-04	43	130	3	EFO_0009399
Disease	cholesteryl ester 20:4 measurement	FADS3 DGCR8 PROSER2	9.70e-04	44	130	3	EFO_0010348
Disease	Microphthalmos	PRSS56 KMT2D	1.03e-03	11	130	2	C0026010
Disease	esophagus squamous cell carcinoma (is_implicated_in)	RUNX1 KMT2D MGMT	1.04e-03	45	130	3	DOID:3748 (is_implicated_in)
Disease	Autistic Disorder	TSC2 TRRAP NLGN3 NF1 ASMT RAB11FIP5	1.08e-03	261	130	6	C0004352
Disease	Congenital muscular dystrophy	FKRP GMPPB	1.24e-03	12	130	2	cv:C0699743
Disease	Condition, Preneoplastic	TSC2 CISH MGMT ATP5F1B	1.45e-03	110	130	4	C0282313
Disease	Precancerous Conditions	TSC2 CISH MGMT ATP5F1B	1.45e-03	110	130	4	C0032927
Disease	Squamous cell carcinoma of the head and neck	WEE1 TSC2 MGMT	1.58e-03	52	130	3	C1168401
Disease	MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2K	FKRP GMPPB	1.69e-03	14	130	2	C1836373
Disease	alpha-Dystroglycanopathies	FKRP GMPPB	1.69e-03	14	130	2	C2936406
Disease	Fukuyama Type Congenital Muscular Dystrophy	FKRP GMPPB	1.69e-03	14	130	2	C0410174
Disease	Muscle eye brain disease	FKRP GMPPB	1.69e-03	14	130	2	C0457133
Disease	Sarcoma, Spindle Cell	NF1 MAML3	1.69e-03	14	130	2	C0205945
Disease	Sarcoma, Epithelioid	NF1 MAML3	1.69e-03	14	130	2	C0205944
Disease	Muscular Dystrophy-Dystroglycanopathy (Congenital with Brain and Eye Anomalies) Type A, 1	FKRP GMPPB	1.69e-03	14	130	2	C4284790
Disease	leukemia	FANCE NF1 MGMT	1.85e-03	55	130	3	C0023418
Disease	mean platelet volume	ARHGAP32 LNX2 SETD1B BLOC1S4 BCORL1 RUNX1 TRANK1 TBC1D4 NFE2L1 PROSER2 BRD1 ATP5F1B	1.88e-03	1020	130	12	EFO_0004584
Disease	Walker-Warburg congenital muscular dystrophy	FKRP GMPPB	1.95e-03	15	130	2	C0265221
Disease	DiGeorge Syndrome	RREB1 DGCR8	2.22e-03	16	130	2	C0012236
Disease	CONOTRUNCAL ANOMALY FACE SYNDROME	RREB1 DGCR8	2.22e-03	16	130	2	C0795907
Disease	Shprintzen syndrome	RREB1 DGCR8	2.22e-03	16	130	2	C0220704
Disease	idiopathic dilated cardiomyopathy	MGAM TCAF1 SAMD5	2.38e-03	60	130	3	EFO_0009094
Disease	obesity (implicated_via_orthology)	DCHS2 ZFHX4 PCSK1N PLCB3 ATP5F1B	2.69e-03	215	130	5	DOID:9970 (implicated_via_orthology)
Disease	Juvenile Myelomonocytic Leukemia	RUNX1 NF1	3.14e-03	19	130	2	C0349639
Disease	Malignant Glioma	SLC5A5 NF1 MGMT	3.69e-03	70	130	3	C0555198
Disease	mixed gliomas	SLC5A5 NF1 MGMT	3.69e-03	70	130	3	C0259783
Disease	Sarcoma	NF1 MAML3	3.83e-03	21	130	2	C1261473
Disease	muscular dystrophy (implicated_via_orthology)	FKRP SNTB2	3.83e-03	21	130	2	DOID:9884 (implicated_via_orthology)
Disease	level of Phosphatidylcholine (16:0_20:4) in blood serum	FADS3 AHNAK	3.83e-03	21	130	2	OBA_2045076
Disease	progression free survival, ovarian serous carcinoma	MGAM VIT	4.20e-03	22	130	2	EFO_0004920, EFO_1001516

Protein segments in the cluster

Peptide	Gene	Start	Entry
LGGAGDDPAIPVIEE	CBARP	631	Q8N350
VPDVDGDGAPDLLVL	FAM234A	216	Q9H0X4
QDPALPADTLLLGDG	CHTF18	606	Q8WVB6
GAALGPEAGEEVLPR	BRD1	776	O95696
PGLVPVSIIGAEDED	ARHGEF1	16	Q92888
PAALVHLGAEEPAGV	ASPSCR1	456	Q9BZE9
IGLPGPDVFIDIDGA	COL4A6	341	Q14031
SEELNVEPGLGRALP	ELK1	231	P19419
AIAEDPPDAIAGLQA	BUB1	706	O43683
LVAEAGPEDAVAPGL	C2orf72	146	A6NCS6
GPEDAVAPGLRLLEA	C2orf72	151	A6NCS6
LPEGLAEEAEPQGAA	BLOC1S4	11	Q9NUP1
AEPAGPDGILVEVDL	CIITA	351	P33076
AEAEGLLVPLSSPGD	BCORL1	106	Q5H9F3
LGPAADEAVAAPLVE	CARNS1	366	A5YM72
VPGGEIDASLKAPDV	AHNAK	5046	Q09666
DVPSVGLEGPDVDLQ	AHNAK	5211	Q09666
LGVFDLLAEAPGPLD	ASMT	31	P46597
LLAEAPGPLDVAAVA	ASMT	36	P46597
PLPAGAFLEEVAEGT	CISH	36	Q9NSE2
EGELPDLPGAEVLLS	ANKRD24	416	Q8TF21
IGALGAPFLLEDPAN	C3orf85	16	A0A1B0GTC6
DEKDPLGAEAAPGAL	DGCR8	406	Q8WYQ5
IPLGSLADPAAEDEG	CAMSAP3	846	Q9P1Y5
DEGLPPILNALEVQG	ATP5F1B	76	P06576
IGFGSALLEEVDPNP	AP2A2	871	O94973
EDLEDLGAVAPPVSG	NFE2L1	151	Q14494
ALEAELQLAAEAPGP	RASSF7	216	Q02833
ELPPGALDGLLRAQE	RAB11FIP5	76	Q9BXF6
ILDIPLDDPGANAAA	NRGN	16	Q92686
LVLPAAQPEDGGEFV	OBSL1	1046	O75147
EPLLPGGATLLQAEE	LARP1	6	Q6PKG0
AAEEGALVAAVEPGP	IL17RA	671	Q96F46
ALVAAVEPGPLADGA	IL17RA	676	Q96F46
VEPGPLADGAAVRLA	IL17RA	681	Q96F46
LVLGPDDPVEAVLGD	FRAS1	3126	Q86XX4
APETGAVLPLALGLA	LRP11	446	Q86VZ4
VPLADPGLDNDVGVE	MID1IP1	41	Q9NPA3
AAAPGLPEVGVSLDD	MAGI2	1246	Q86UL8
LPEVGVSLDDGLAPF	MAGI2	1251	Q86UL8
PGLPDGADLVDSIIK	MAML3	1106	Q96JK9
AGDVEADPGLADLPQ	GRWD1	391	Q9BQ67
VDLILEASEAGRPPG	LGR6	876	Q9HBX8
GPGLLITPVLDEGAE	MGAM	761	O43451
ADAVEVPAPAAVLGG	MGMT	41	P16455
EEPLGTAGPLALARD	GMPPB	81	Q9Y5P6
EPGVFILDLLEGGLA	LNX2	361	Q8N448
VLPGDGNADGLKEPL	CD1A	11	P06126
GVLLPTPGEAQDADL	FCGRT	341	P55899
VGSELPPEGVLGALL	PCSK1N	226	Q9UHG2
LDAPGSINGVPLLEV	FIP1L1	141	Q6UN15
PPGLAGHAAALVDDV	MEGF8	331	Q7Z7M0
PVAGGDLLLEPSLAQ	PTPRZ1	861	P23471
ARGADVPEIPGDLTL	ARHGAP32	76	A7KAX9
ALAVQLLEPAELGPG	MFSD3	121	Q96ES6
APEPGEALELSLAGA	INO80B	16	Q9C086
EAGALGPARETELPA	PTPRS	971	Q13332
LSVDEGLPPDTLVGD	DCHS2	71	Q6V1P9
PAGEEPVAGQEALTL	POP1	931	Q99575
GGEENGILPLEALDL	PLCB3	301	Q01970
GAPELGAAPEEELAA	NLGN3	751	Q9NZ94
GAAPEEELAALQLGP	NLGN3	756	Q9NZ94
VPLVAAGPCDDEGIV	BOD1L1	1841	Q8NFC6
EADQAPGVEPGDIVL	DNAJA2	236	O60884
IPALALSVAGIPGLD	DOCK2	1761	Q92608
SAPGPLELDLTGDLE	ARHGDIA	81	P52565
GEGALELVLEAAGAP	DNLZ	141	Q5SXM8
AIVLGALAGPDPRDS	QRSL1	241	Q9H0R6
GDAVQLASLPPAGDI	CELA3A	136	P09093
PEGVARGPDALTLLE	CDK5RAP3	331	Q96JB5
AEFLALVGGQPPALE	CC2D1A	46	Q6P1N0
GDAVQLASLPPAGDI	CELA3B	136	P08861
EADILAITGPEDQPG	BNIP2	26	Q12982
VDLNLAGEPTEGAPV	FZD3	141	Q9NPG1
KLVPLLLEDGGEAPA	DYNC1H1	36	Q14204
SRDLLAGLPAPGVEV	LCAT	321	P04180
ALDLDAGLEPSPGLE	IL21R	401	Q9HBE5
GLEGLEDAPPVELQL	FANCE	301	Q9HB96
VALVPDGARAEAPGL	FKRP	126	Q9H9S5
EESLPLGPLLGDTAV	DDAH2	66	O95865
DLGPRGPDLAVLQAE	EPS8L1	241	Q8TE68
GDLGTAPDEAVRAPL	CREB3	21	O43889
LLIGELAPEEPSQDG	FADS3	91	Q9Y5Q0
LNDISLGEPDLLAPG	DOK4	116	Q8TEW6
LEAVPGGLPLDTELL	LINGO4	51	Q6UY18
AFRVAALAEGEPEGP	PRSS56	561	P0CW18
DSNELAPDGLGLVPI	CFAP221	546	Q4G0U5
SEALPLGAPDAGAAL	RUNX1	26	Q01196
VGLGTEEDPSLPALL	POLR1A	1466	O95602
IGDPDLDAIGVLAPA	SAMD5	36	Q5TGI4
GPDGAAFLQIPAEEI	TCAF1	441	Q9Y4C2
LDSDPVGLGDPLSEI	PLEKHG4	146	Q58EX7
DVIDLVQPAPGAGEA	PROSER2	106	Q86WR7
DDLQGPEGLLLPSEA	KCP	1356	Q6ZWJ8
GGDIPASVAELVALP	NTHL1	201	P78549
KAGGPAAAEPLLAAE	SFT2D3	16	Q587I9
APGATVKAEGALPLE	SMIM32	21	A0A1B0GUA5
LGLGAPPAREAEAEA	SELENOO	106	Q9BVL4
TGEAAAAAAEEPLLP	SHCBP1L	81	Q9BZQ2
DPADLVLSSVPGGEL	TEF	186	Q10587
IVDAVGLPSDDRGPL	SBNO2	681	Q9Y2G9
QDGEEAALAPGAPAV	SETD1B	1211	Q9UPS6
LQDLAGGIFPEDEIP	RRP1	331	P56182
SPGPQEEDGEVALVL	SCRIB	1581	Q14160
DTPILLEAPTGLAEG	SP110	116	Q9HB58
AVFIDGPLALADGIP	TRPT1	176	Q86TN4
GLGSLEEAVEALDPP	ARHGAP4	301	P98171
EDEAPLGELVLPSGA	CILP2	576	Q8IUL8
EAALPELLLGALPVG	RETREG3	376	Q86VR2
DPTDLAGVIIELGPN	TPTE	6	P56180
LDPATAAALAPGLGE	ZFHX4	851	Q86UP3
EDLLLPGACPGADEA	WEE1	91	P30291
AASGEDPVLGEVDPL	RP1L1	351	Q8IWN7
LAADGLGPAEAPAAE	RREB1	826	Q92766
DIFEDLPGVPGLFLA	SLC5A5	331	Q92911
GEAGLLPALDLSIPQ	PRX	981	Q9BXM0
LGLQLLPEGPAADEV	USP35	106	Q9P2H5
PPGAEASNILVGELE	SLC4A10	326	Q6U841
PGSLRAVDIPGLEAA	TNC	1396	P24821
LADVAQALDIGPAGP	VIT	316	Q6UXI7
AGLPLQPEEGDGVEL	NF1	1081	P21359
AAEPTVDLLGLDGPA	SMAP1	211	Q8IYB5
VDLLGLDGPAVAPVT	SMAP1	216	Q8IYB5
AAIALPGLEGPATDA	SPCS1	21	Q9Y6A9
DLADLEVVVPGSPGD	TBC1D4	251	O60343
LALESEAGVPALVGP	UNC5A	736	Q6ZN44
PGSPEEAAALVEGLQ	ZNF446	91	Q9NWS9
GALPEAAALEQPAEL	XPA	6	P23025
PQEEAEGLAAALGPR	ZXDA	241	P98168
AIGGLLAEPAPAALA	ZNF316	671	A6NFI3
DGAPALGKSPLEVEA	TPRN	376	Q4KMQ1
AVEDLPGTPIGDALV	ZNF831	566	Q5JPB2
AEPEKILGLAPGGLE	TRANK1	2031	O15050
TGDAAAAELEPALGP	SNTB2	51	Q13425
ELGAVEAALPGVPTA	TRRAP	476	Q9Y4A5
PQEAVPLGLGLEDAD	TEX19	126	Q8NA77
LVEPPGLEDVEAALG	TSC2	1311	P49815
APEAPLLGLAEVAAA	ZNF296	191	Q8WUU4
LSGDGQPDEVIPADL	KMT2D	1721	O14686
VALGIGAVPIDDPED	LGMN	11	Q99538
AVLGALGAEEPLPAR	N4BP1	36	O75113