Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	CKM complex	CDK8 CDK19	6.52e-05	5	54	2	GO:1990508
Domain	Znf_C2H2-like	ZNF155 SF3A3 ZFTA ZBTB26 ZNF350 POGZ ZNF91 ZXDA ZFP37 ZNF404	8.14e-05	796	54	10	IPR015880
Domain	Znf_C2H2	TRIT1 ZNF155 SF3A3 ZBTB26 ZNF350 POGZ ZNF91 ZXDA ZFP37 ZNF404	8.94e-05	805	54	10	IPR007087
Domain	ZnF_C2H2	ZNF155 SF3A3 ZFTA ZBTB26 ZNF350 POGZ ZNF91 ZXDA ZFP37 ZNF404	9.22e-05	808	54	10	SM00355
Domain	ZINC_FINGER_C2H2_1	TRIT1 ZNF155 ZBTB26 ZNF350 POGZ ZNF91 ZXDA ZFP37 ZNF404	3.53e-04	777	54	9	PS00028
Domain	zf-C2H2	ZNF155 ZBTB26 ZNF350 POGZ ZNF91 ZXDA ZFP37 ZNF404	7.93e-04	693	54	8	PF00096
Domain	ZF_MATRIN	TRIT1 SF3A3	1.22e-03	18	54	2	PS50171
Domain	DSRM	DGCR8 EIF2AK2	1.36e-03	19	54	2	SM00358
Domain	dsrm	DGCR8 EIF2AK2	1.51e-03	20	54	2	PF00035
Domain	ZINC_FINGER_C2H2_2	ZNF155 ZBTB26 ZNF350 POGZ ZNF91 ZXDA ZFP37 ZNF404	1.63e-03	775	54	8	PS50157
Domain	DS_RBD	DGCR8 EIF2AK2	1.66e-03	21	54	2	PS50137
Domain	NACHT	NOD1 TEP1	2.00e-03	23	54	2	PS50837
Domain	NACHT_NTPase	NOD1 TEP1	2.00e-03	23	54	2	IPR007111
Domain	-	DGCR8 EIF2AK2	2.75e-03	27	54	2	3.30.160.20
Domain	dsRBD_dom	DGCR8 EIF2AK2	2.96e-03	28	54	2	IPR014720
Domain	-	ZNF155 ZBTB26 ZNF350 ZNF91 ZXDA ZFP37 ZNF404	3.26e-03	679	54	7	3.30.160.60
Domain	Ser/Thr_kinase_AS	CDK8 CDK19 MAP3K13 EIF2AK2 MAP4K2	3.64e-03	357	54	5	IPR008271
Domain	Znf_C2H2/integrase_DNA-bd	ZNF155 ZBTB26 ZNF350 ZNF91 ZXDA ZFP37 ZNF404	3.68e-03	694	54	7	IPR013087
Domain	KRAB	ZNF155 ZNF350 ZNF91 ZFP37 ZNF404	3.69e-03	358	54	5	PS50805
Domain	KRAB	ZNF155 ZNF350 ZNF91 ZFP37 ZNF404	3.69e-03	358	54	5	PF01352
Domain	S_TKc	CDK8 CDK19 MAP3K13 EIF2AK2 MAP4K2	3.73e-03	359	54	5	SM00220
Domain	PROTEIN_KINASE_ST	CDK8 CDK19 MAP3K13 EIF2AK2 MAP4K2	3.86e-03	362	54	5	PS00108
Domain	KRAB	ZNF155 ZNF350 ZNF91 ZFP37 ZNF404	4.19e-03	369	54	5	SM00349
Domain	KRAB	ZNF155 ZNF350 ZNF91 ZFP37 ZNF404	4.24e-03	370	54	5	IPR001909
Domain	Kinase-like_dom	CDK8 TRPM6 CDK19 MAP3K13 EIF2AK2 MAP4K2	4.61e-03	542	54	6	IPR011009
Domain	Pkinase	CDK8 CDK19 MAP3K13 EIF2AK2 MAP4K2	4.80e-03	381	54	5	PF00069
Domain	Ankyrin_rpt	EXO1 ANKRD62 CAMTA2 MYO16	6.91e-03	262	54	4	IPR002110
Domain	Leu-rich_rpt	LRR1 NOD1 ASPN RXFP2	7.77e-03	271	54	4	IPR001611
Pubmed	Mediator kinase inhibition further activates super-enhancer-associated genes in AML.	CDK8 CDK19	2.37e-06	2	54	2	26416749
Pubmed	CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.	CDK8 CDK19	2.37e-06	2	54	2	28855340
Pubmed	Functional dissection of transcription factor ZBRK1 reveals zinc fingers with dual roles in DNA-binding and BRCA1-dependent transcriptional repression.	BRCA1 ZNF350	2.37e-06	2	54	2	14660588
Pubmed	Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.	CDK8 CDK19	2.37e-06	2	54	2	35181333
Pubmed	Regulatory functions of the Mediator kinases CDK8 and CDK19.	CDK8 CDK19	2.37e-06	2	54	2	30585107
Pubmed	PFKP is transcriptionally repressed by BRCA1/ZBRK1 and predicts prognosis in breast cancer.	BRCA1 ZNF350	2.37e-06	2	54	2	32470015
Pubmed	Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer.	CDK8 CDK19	2.37e-06	2	54	2	27678455
Pubmed	Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1.	BRCA1 ZNF350	2.37e-06	2	54	2	11090615
Pubmed	HIV Transcription Is Independent of Mediator Kinases.	CDK8 CDK19	2.37e-06	2	54	2	31044597
Pubmed	CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF.	CDK8 CDK19	2.37e-06	2	54	2	36006697
Pubmed	CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.	CDK8 CDK19	2.37e-06	2	54	2	37378433
Pubmed	Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk.	DDX39B IL7R	2.37e-06	2	54	2	28340352
Pubmed	Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection.	CDK8 CDK19	2.37e-06	2	54	2	32560467
Pubmed	[Mechanisms of transcriptional regulation upon protein phosphorylation by mediator complexes].	CDK8 CDK19	2.37e-06	2	54	2	20408451
Pubmed	EXO1 protects BRCA1-deficient cells against toxic DNA lesions.	BRCA1 EXO1	2.37e-06	2	54	2	38266640
Pubmed	Identification of target genes for the CDK subunits of the Mediator complex.	CDK8 CDK19	2.37e-06	2	54	2	22117896
Pubmed	ZGRF1 promotes end resection of DNA homologous recombination via forming complex with BRCA1/EXO1.	BRCA1 EXO1	7.09e-06	3	54	2	34552057
Pubmed	Mediator complex cooperatively regulates transcription of retinoic acid target genes with Polycomb Repressive Complex 2 during neuronal differentiation.	CDK8 CDK19	7.09e-06	3	54	2	26002960
Pubmed	Loss of ZBRK1 contributes to the increase of KAP1 and promotes KAP1-mediated metastasis and invasion in cervical cancer.	BRCA1 ZNF350	7.09e-06	3	54	2	23991171
Pubmed	PARylation of BRCA1 limits DNA break resection through BRCA2 and EXO1.	BRCA1 EXO1	7.09e-06	3	54	2	36735534
Pubmed	Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation.	BRCA1 ZNF350	7.09e-06	3	54	2	30714292
Pubmed	Polymorphisms in BRCA1, BRCA1-interacting genes and susceptibility of breast cancer in Chinese women.	BRCA1 ZNF350	7.09e-06	3	54	2	19484476
Pubmed	Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9.	CDK8 CDK19	7.09e-06	3	54	2	28151579
Pubmed	Pathway analysis of single-nucleotide polymorphisms potentially associated with glioblastoma multiforme susceptibility using random forests.	BRCA1 EXO1	1.42e-05	4	54	2	18559551
Pubmed	Derepression of HMGA2 via removal of ZBRK1/BRCA1/CtIP complex enhances mammary tumorigenesis.	BRCA1 ZNF350	1.42e-05	4	54	2	20007691
Pubmed	Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.	CDK8 CDK19	1.42e-05	4	54	2	29440396
Pubmed	Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature.	BRCA1 ZNF350	1.42e-05	4	54	2	16843262
Pubmed	Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development.	CDK8 CDK19	1.42e-05	4	54	2	32439758
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	NAT2 NOD1 BRCA1 EXO1 REV3L DDX39B	1.74e-05	351	54	6	20453000
Pubmed	CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.	CDK8 CDK19	2.36e-05	5	54	2	36545778
Pubmed	HMGA2 is regulated by LIN28 and BRCA1 in human placental cells.	BRCA1 ZNF350	2.36e-05	5	54	2	30137214
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	RESF1 BRCA1 POGZ REV3L NOL8	2.48e-05	222	54	5	37071664
Pubmed	Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes.	BRCA1 ZNF350	3.54e-05	6	54	2	15113441
Pubmed	Genetic susceptibility to distinct bladder cancer subphenotypes.	NAT2 BRCA1 EXO1 ZNF350 TEP1 IL7R	4.80e-05	421	54	6	19692168
Pubmed	Factors associated with the mammalian RNA polymerase II holoenzyme.	CDK8 BRCA1	4.94e-05	7	54	2	9443979
Pubmed	EXD2 promotes homologous recombination by facilitating DNA end resection.	BRCA1 EXO1	4.94e-05	7	54	2	26807646
Pubmed	Single-nucleotide polymorphisms in the p53 pathway genes modify cancer risk in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent.	BRCA1 ZNF350	4.94e-05	7	54	2	20306497
Pubmed	Mediator CDK subunits are platforms for interactions with various chromatin regulatory complexes.	CDK8 CDK19	4.94e-05	7	54	2	22668559
Pubmed	CtIP-mediated resection is essential for viability and can operate independently of BRCA1.	BRCA1 EXO1	4.94e-05	7	54	2	24842372
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CDK8 RESF1 BRCA1 UTP25 POGZ REV3L TEP1 BRWD1 NIN	5.07e-05	1116	54	9	31753913
Pubmed	The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7.	CDK8 CDK19	6.59e-05	8	54	2	30695077
Pubmed	Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes.	CDK8 CDK19	6.59e-05	8	54	2	23749998
Pubmed	ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis.	BRCA1 EXO1	6.59e-05	8	54	2	32051414
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	CDK8 BRCA1 CDK19 DGCR8 MIDEAS DDX39B	7.19e-05	453	54	6	29656893
Pubmed	Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.	BRCA1 RTN2 DDX39B	7.84e-05	53	54	3	14499622
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	BRCA1 INTS4 POGZ MIDEAS	8.01e-05	146	54	4	23892456
Pubmed	PHF11 promotes DSB resection, ATR signaling, and HR.	BRCA1 EXO1	8.46e-05	9	54	2	28115467
Pubmed	Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice.	BRCA1 EXO1	8.46e-05	9	54	2	24705021
Pubmed	Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.	ZNF350 ZNF91	8.46e-05	9	54	2	23665872
Pubmed	WT1 regulates expression of DNA repair gene Neil3 during nephrogenesis.	BRCA1 EXO1	1.06e-04	10	54	2	36546838
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	CDK8 RESF1 POGZ MIDEAS	1.34e-04	167	54	4	20362541
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	UTP25 BMS1 SF3A3 DGCR8 MIDEAS EIF2AK2 DDX39B NOL8	1.36e-04	989	54	8	36424410
Pubmed	Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair.	BRCA1 REV3L	1.55e-04	12	54	2	28700933
Pubmed	A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction.	CDK8 CDK19	1.55e-04	12	54	2	23563140
Pubmed	BRCA1 is a component of the RNA polymerase II holoenzyme.	CDK8 BRCA1	1.55e-04	12	54	2	9159119
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	BRCA1 SF3A3 EXO1 INTS4 POGZ MIDEAS DDX39B NOL8 ITPR3	1.56e-04	1294	54	9	30804502
Pubmed	Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.	NAT2 NOD1 EXO1 REV3L	1.76e-04	179	54	4	19074885
Pubmed	Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.	BRCA1 MIDEAS DDX39B	2.39e-04	77	54	3	19505873
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TRPM6 RESF1 PAPOLA SOCS5 RXFP2 CAMTA2 ZFP37 BRWD1	2.53e-04	1084	54	8	11544199
Pubmed	Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.	CDK8 MAP3K13	2.80e-04	16	54	2	8274451
Pubmed	PTEN identified as important risk factor of chronic obstructive pulmonary disease.	BRCA1 EXO1 ZNF350 TEP1 IL7R	2.87e-04	374	54	5	19625176
Pubmed	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	BRCA1 EXO1 ZNF350 TEP1 IL7R	3.13e-04	381	54	5	18676680
Pubmed	Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.	BRCA1 EXO1 ZNF350 TEP1 IL7R	3.17e-04	382	54	5	19170196
Pubmed	Influence of polymorphisms in xenobiotic-metabolizing genes and DNA-repair genes on diepoxybutane-induced SCE frequency.	NAT2 BRCA1	3.17e-04	17	54	2	17078101
Pubmed	Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.	BRCA1 EXO1 REV3L	3.42e-04	87	54	3	17148452
Pubmed	Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6.	EIF2AK2 DDX39B IL7R	3.78e-04	90	54	3	23151878
Pubmed	Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.	ZNF155 ZNF404	4.42e-04	20	54	2	12743021
Pubmed	SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243.	SF3A3 ZNF91 DDX39B	4.43e-04	95	54	3	33863777
Pubmed	Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.	NOD1 SOCS5 TEP1 EIF2AK2	4.62e-04	231	54	4	21048031
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	RESF1 ZBTB26 NIN	5.29e-04	101	54	3	10997877
Pubmed	Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population.	NAT2 BRCA1	5.36e-04	22	54	2	12768436
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	BRCA1 SF3A3 POGZ DGCR8 MIDEAS DDX39B NOL8	6.59e-04	954	54	7	36373674
Pubmed	siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.	EXO1 REV3L	7.51e-04	26	54	2	23435420
Pubmed	Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China.	BRCA1 REV3L	8.72e-04	28	54	2	19661089
Pubmed	Purification of CpG islands using a methylated DNA binding column.	DDX39B SPICE1	8.72e-04	28	54	2	8012384
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	UTP25 BMS1 SF3A3 INTS4 NOL8 NIN	8.74e-04	723	54	6	34133714
Pubmed	AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair.	SOCS5 KATNIP ZFP37	8.95e-04	121	54	3	31900314
Pubmed	Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.	RESF1 ZBTB26 POGZ	9.83e-04	125	54	3	32891193
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	PAPOLA BMS1 DDX39B NOL8	9.86e-04	283	54	4	30585729
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	RESF1 KATNIP MYO16	1.10e-03	130	54	3	12421765
Interaction	HMMR interactions	NAT2 BRCA1 MAP4K2 SPICE1 NIN	8.96e-06	109	52	5	int:HMMR
Interaction	DUXB interactions	RESF1 POGZ MIDEAS	1.29e-05	18	52	3	int:DUXB
Interaction	ZNF350 interactions	CDK8 BRCA1 ZNF350	1.52e-05	19	52	3	int:ZNF350
Interaction	ZBTB48 interactions	BRCA1 BMS1 ZBTB26 DGCR8 ZFP37	5.37e-05	158	52	5	int:ZBTB48
Interaction	TP53BP1 interactions	CDK8 POU6F2 BRCA1 CDK19 DGCR8 MAP3K13 DDX39B NOL8	6.14e-05	533	52	8	int:TP53BP1
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	BRCA1 EIF2AK2 MYO16 ITPR3	7.37e-04	181	41	4	694
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF155 ZBTB26 ZNF350 ZNF91 ZXDA ZFP37 ZNF404	1.05e-03	718	41	7	28
GeneFamily	Cyclin dependent kinases	CDK8 CDK19	1.58e-03	26	41	2	496
GeneFamily	Cyclins\|Mediator complex	CDK8 CDK19	2.53e-03	33	41	2	1061
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	RESF1 LY75	5.96e-03	51	41	2	870
ToppCell	droplet-Lung-nan-18m-Myeloid-Proliferating_Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRR1 POU6F2 BRCA1 EXO1 FASTKD3	2.76e-06	182	54	5	11494a66d986297b837332ee9d382b71b9f22591
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LRR1 POU6F2 BRCA1 EXO1 FASTKD3	2.84e-06	183	54	5	6c1d7ce60e67bf1df364a4e177c351e7313eb41f
ToppCell	VE-CD8-naive_CD4\|VE / Condition, Cell_class and T cell subcluster	NOD1 ZNF155 BMS1 ZFTA	4.24e-05	160	54	4	255d2a150bfe19ee3d4d34533feb9c37ce73d225
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|356C / Donor, Lineage, Cell class and subclass (all cells)	RESF1 MAP3K13 LY75 SPICE1	4.89e-05	166	54	4	c4f7ea1cad962b1d6ad77423d15978b68a0d6f1d
ToppCell	droplet-Lung-nan-18m-Myeloid-Proliferating_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRR1 SLC9A5 BRCA1 EXO1	5.75e-05	173	54	4	20a20429aa898097d5ec4880ed64846558b5890f
ToppCell	droplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LRR1 SLC9A5 BRCA1 EXO1	6.01e-05	175	54	4	a6913f992a1ea20b43e5adeca3ede3a6fda820ad
ToppCell	10x3'2.3-week_12-13-Myeloid_macrophage-stroma-erythroid_macrophage\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	NOD1 ASPN ZFP37 ZNF404	6.56e-05	179	54	4	c17ae394b855f01f8ca1765c416fd8b34a96e60b
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	GPR18 UTP25 CAMTA2 TEP1	6.70e-05	180	54	4	81d60f0fa9e3b5bfcec85139a0a49e9130145f0e
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic-T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRR1 GPR18 EXO1 IL7R	6.70e-05	180	54	4	8cef63866c205df3825df84ce51fa61aa04ae491
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-CD4-positive,_alpha-beta_T_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RESF1 EIF2AK2 DDX39B IL7R	7.45e-05	185	54	4	406b52516b26e9fe2c9e768950af447ec7ad5f3e
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-CD4-positive,_alpha-beta_T_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RESF1 EIF2AK2 DDX39B IL7R	7.45e-05	185	54	4	f2ebd099c8dfcfaca4298bcdd618c50701a9c2c8
ToppCell	ASK452-Immune-T_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	RESF1 BMS1 IL7R NOL8	8.10e-05	189	54	4	f5dc500f77f04a110dd4a65cf4c03068a495dbdb
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-T4_em\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RESF1 EIF2AK2 DDX39B IL7R	8.26e-05	190	54	4	1634a6044dce4e026a63976031a498c7460e3dce
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-T4_em-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RESF1 EIF2AK2 DDX39B IL7R	8.26e-05	190	54	4	08813c2f9321b82f0ec66854bb7a383aa1171780
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-T4_em\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RESF1 EIF2AK2 DDX39B IL7R	8.60e-05	192	54	4	e07b6892276c81c1227e94ca942f6820d89a7ca3
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RESF1 EIF2AK2 DDX39B IL7R	8.95e-05	194	54	4	9588a9b4baebbae08e13d201d4b9dfcf0e6521fb
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-T4_em-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RESF1 EIF2AK2 DDX39B IL7R	8.95e-05	194	54	4	0b0042b6a356a49a059fb64a1e1abb25c82d48cf
ToppCell	390C-Myeloid-Dendritic-cDC_proliferating_1\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	LRR1 NOD1 BRCA1 MAP4K2	9.32e-05	196	54	4	36ed1918f70b6f5760bb088b15ce422998055cc7
ToppCell	BAL-Mild-cDC_10\|Mild / Compartment, Disease Groups and Clusters	ATP11C MAP3K13 LY75 IL7R	9.50e-05	197	54	4	c0550d41dd5619b369b590f3d6a61154dd7b2cab
ToppCell	systemic_lupus_erythematosus-flare\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RESF1 EIF2AK2 DDX39B IL7R	9.69e-05	198	54	4	4c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCell	BAL-Severe-cDC_10\|Severe / Compartment, Disease Groups and Clusters	ATP11C MAP3K13 LY75 IL7R	9.88e-05	199	54	4	54bdadd04abaf8caa948b0177c037bc089ca07e6
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	RESF1 IL7R BRWD1 NIN	1.01e-04	200	54	4	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
Computational	Neighborhood of BRCA1	CDK8 POU6F2 GPR18 BRCA1 REV3L BRWD1	1.81e-04	263	35	6	MORF_BRCA1
Disease	developmental and epileptic encephalopathy 87 (implicated_via_orthology)	CDK8 CDK19	2.93e-06	2	51	2	DOID:0112221 (implicated_via_orthology)
Disease	stomach cancer (is_implicated_in)	BRCA1 TEP1 IL7R	2.67e-04	72	51	3	DOID:10534 (is_implicated_in)
Disease	Breast Carcinoma	NAT2 BRCA1 SETBP1 EXO1 MAP3K13 ZNF404	3.21e-04	538	51	6	C0678222
Disease	blood tin measurement	NAT2 EXO1	8.57e-04	25	51	2	EFO_0021530
Disease	cleft lip	BRCA1 UTP25 MYO16 ZNF404	1.47e-03	284	51	4	EFO_0003959
Disease	plasma betaine measurement	LY75 MYO16	1.59e-03	34	51	2	EFO_0007787
Disease	Nephroblastoma	POU6F2 DGCR8	1.78e-03	36	51	2	C0027708
Disease	colon cancer (is_implicated_in)	BRCA1 IL7R	1.78e-03	36	51	2	DOID:219 (is_implicated_in)
Disease	Mammary Carcinoma, Human	NAT2 BRCA1 SETBP1 EXO1 ZNF404	2.09e-03	525	51	5	C4704874
Disease	Mammary Neoplasms, Human	NAT2 BRCA1 SETBP1 EXO1 ZNF404	2.09e-03	525	51	5	C1257931
Disease	Mammary Neoplasms	NAT2 BRCA1 SETBP1 EXO1 ZNF404	2.13e-03	527	51	5	C1458155
Disease	Neoplasm of uncertain or unknown behavior of breast	BRCA1 MAP3K13	2.30e-03	41	51	2	C0496956
Disease	Breast adenocarcinoma	BRCA1 MAP3K13	2.30e-03	41	51	2	C0858252
Disease	Malignant neoplasm of breast	NAT2 BRCA1 SETBP1 EXO1 MAP3K13 FASTKD3 ZNF404	2.37e-03	1074	51	7	C0006142
Disease	smoking behavior	POU6F2 SETBP1 REV3L BRWD1	2.86e-03	341	51	4	EFO_0004318
Disease	triglyceride measurement, low density lipoprotein cholesterol measurement	NAT2 MAP4K2 BRWD1	2.99e-03	166	51	3	EFO_0004530, EFO_0004611

Protein segments in the cluster

Peptide	Gene	Start	Entry
HIIKFHRASKANKKP	CDK19	106	Q9BWU1
RNKSLNLKHIKHFIL	DDX39B	181	Q13838
IHNLLHGRTSKLKPK	GPR18	211	Q14330
LIHKIKNRKPDNHQS	ANKRD62	331	A6NC57
ENSHHLKIFLPKKLL	CAMTA2	11	O94983
YAKKNKPNLHILSKL	DGCR8	721	Q8WYQ5
RQKKHFNSLHIPKAL	BMS1	1156	Q14692
LILNNNKLTKIHPKA	ASPN	131	Q9BXN1
KKLRLTKPSKSAALH	INTS4	26	Q96HW7
SRHNKQLQHLLKPVK	ITPR3	2061	Q14573
FHHFLKLALTKNPKK	MAP4K2	246	Q12851
KLHPHDKRKVARSLQ	TRIT1	176	Q9H3H1
KLDLSHNHIKKLPAT	LRR1	181	Q96L50
KRLKHAKNPKVHFNL	MYO16	46	Q9Y6X6
NRILKHLKSKDPVQL	KATNIP	46	O60303
LSKAKQKLLRHLVPA	NOD1	596	Q9Y239
KCQKLNPKSHILSIR	LY75	1276	O60449
KTLEHLCKKPRKNLN	IL7R	281	P16871
PVLHLKNQHKRKIIK	NOL8	151	Q76FK4
LLPNHVLQKKKKHST	PAPOLA	496	P51003
KHLRKLKHPNIIAFK	MAP3K13	206	O43283
LELNIHNSKAPKKNR	BRCA1	596	P38398
HSKKLIHRDLKPSNI	EIF2AK2	406	P19525
KLPHRNASAAAKKKL	BRWD1	2266	Q9NSI6
LNKLLLKKPLRPHNH	MIDEAS	806	Q6PJG2
LNSHLLPKKKHQKIY	NAT2	176	P11245
HIIKFHRASKANKKP	CDK8	106	P49336
NQLSHIKAKIRAKIP	RTN2	511	O75298
QLLNTLTKKQKKHLR	UTP25	11	Q68CQ4
KQSKPLFSNKRKIHL	SOCS5	196	O75159
KVRQLESNLLPKHQK	NIN	1876	Q8N4C6
LNPLQNHKRKKLRFH	RESF1	1286	Q9HCM1
ALKNTIKRLKQHEPA	POU6F2	661	P78424
ALAALKNKPLNHVHK	FASTKD3	21	Q14CZ7
KLQHHKTFRKPKQLE	POGZ	666	Q7Z3K3
LLSLKKNKIHSLPDK	RXFP2	141	Q8WXD0
LKVKRSEHHKPTLNQ	SLC9A5	456	Q14940
LSKKPASIQKRKHHN	EXO1	766	Q9UQ84
KQLLNKVKRKPNLHA	SPICE1	291	Q8N0Z3
SVPKFKHLKKLLLAH	ATP11C	851	Q8NB49
NPKLKQNAKKFLLHS	TAS2R1	281	Q9NYW7
ALLAKRKHSTCKKLP	TRPM6	1236	Q9BX84
LKKLVQRLHIHKPAQ	TEP1	441	Q99973
KPSRLKLNKRKLAGH	REV3L	826	O60673
IFKKHKSLPLHKRNN	ZNF404	111	Q494X3
FISPKHQKTRKLEKH	ZNF350	191	Q9GZX5
LTLNKHKIIHSREKP	ZNF91	531	Q05481
KLKRHLQSHDKLRPF	ZXDA	316	P98168
ILNHKRLHCQKKPFK	ZNF155	471	Q12901
NRLKQIKEFHRKHPN	SF3A3	86	Q12874
NFLAHESLKKPKHKR	SETBP1	926	Q9Y6X0
SLGKKNNLHKKHVPS	ZFP37	156	Q9Y6Q3
NNLHKKHVPSKKRLL	ZFP37	161	Q9Y6Q3
KPVLRKHLKQLHGKN	ZBTB26	366	Q9HCK0
LKLSTIKRHIRQKHP	ZFTA	136	C9JLR9