Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	epoxide hydrolase activity	EPHX2 RNPEP EPHX4	6.82e-05	11	152	3	GO:0004301
GeneOntologyMolecularFunction	hydrolase activity, acting on ether bonds	EPHX2 RNPEP EPHX4	1.17e-04	13	152	3	GO:0016801
GeneOntologyMolecularFunction	ether hydrolase activity	EPHX2 RNPEP EPHX4	1.17e-04	13	152	3	GO:0016803
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH2 DNAH14 DNAH12	3.24e-04	18	152	3	GO:0008569
Domain	fn3	LRRN1 COL20A1 TNC OBSCN CMYA5 ANOS1 CSF3R USH2A PRLR CNTN2	8.51e-07	162	152	10	PF00041
Domain	FN3	LRRN1 COL20A1 TNC OBSCN CMYA5 ANOS1 CSF3R USH2A PRLR CNTN2	2.84e-06	185	152	10	SM00060
Domain	FN3	LRRN1 COL20A1 TNC OBSCN CMYA5 ANOS1 CSF3R USH2A PRLR CNTN2	5.43e-06	199	152	10	PS50853
Domain	FN3_dom	LRRN1 COL20A1 TNC OBSCN CMYA5 ANOS1 CSF3R USH2A PRLR CNTN2	8.37e-06	209	152	10	IPR003961
Domain	VWFA	CLCA4 COL20A1 ITGAD ITGB5 HMCN1 VWA5A	5.54e-05	82	152	6	PS50234
Domain	VWA	CLCA4 COL20A1 ITGAD ITGB5 HMCN1 VWA5A	6.34e-05	84	152	6	SM00327
Domain	VWF_A	CLCA4 COL20A1 ITGAD ITGB5 HMCN1 VWA5A	1.58e-04	99	152	6	IPR002035
Domain	Dynein_heavy_chain_D4_dom	DNAH2 DNAH14 DNAH12	1.80e-04	14	152	3	IPR024317
Domain	AAA_8	DNAH2 DNAH14 DNAH12	1.80e-04	14	152	3	PF12780
Domain	Interferon_reg_fac2-bd1_2_Znf	IRF2BP1 IRF2BPL	1.96e-04	3	152	2	IPR022750
Domain	IRF-2BP1_2	IRF2BP1 IRF2BPL	1.96e-04	3	152	2	PF11261
Domain	DHC_fam	DNAH2 DNAH14 DNAH12	2.24e-04	15	152	3	IPR026983
Domain	Dynein_heavy	DNAH2 DNAH14 DNAH12	2.24e-04	15	152	3	PF03028
Domain	Dynein_heavy_dom	DNAH2 DNAH14 DNAH12	2.24e-04	15	152	3	IPR004273
Domain	-	CLCA4 COL20A1 ITGB5 HMCN1 VWA5A	3.43e-04	74	152	5	3.40.50.410
Pubmed	Biological insights from 108 schizophrenia-associated genetic loci.	EPHX2 CACNA1C MSANTD2 SLC35G2 GRIN2A SLC7A6 RGS6 PLCH2 GIGYF2 NUTF2	1.39e-06	303	158	10	25056061
Pubmed	Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains.	LRRN1 TAS2R31 TAS2R43 TAS2R46	1.02e-05	30	158	4	17273929
Pubmed	The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.	TAS2R31 TAS2R43 TAS2R46	1.96e-05	12	158	3	12379855
Pubmed	Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3.	SOX4 SOX15	2.05e-05	2	158	2	9730625
Pubmed	Bitter taste receptors for saccharin and acesulfame K.	TAS2R31 TAS2R43	2.05e-05	2	158	2	15537898
Pubmed	Murine mCLCA6 is an integral apical membrane protein of non-goblet cell enterocytes and co-localizes with the cystic fibrosis transmembrane conductance regulator.	CLCA4 CFTR	2.05e-05	2	158	2	18285349
Pubmed	Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates.	DERL1 CFTR	2.05e-05	2	158	2	34686332
Pubmed	Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin.	TAS2R31 TAS2R43	2.05e-05	2	158	2	17702579
Pubmed	Physicians' perceived usefulness of and satisfaction with test reports for cystic fibrosis (DeltaF508) and factor V Leiden.	CFTR F5	2.05e-05	2	158	2	12792424
Pubmed	Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels.	CACNA1B CACNA1C	2.05e-05	2	158	2	22590648
Pubmed	Rare adult pilocytic astrocytoma of the septum pellucidum with novel RIN2::BRAF fusion.	BRAF RIN2	2.05e-05	2	158	2	36520196
Pubmed	Transcription Factor Sox4 as a Potential Player in Mammary Gland Involution.	SOX4 TNC	2.05e-05	2	158	2	31408364
Pubmed	Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice.	TAS2R31 TAS2R43 TAS2R46	2.54e-05	13	158	3	15938754
Pubmed	Identification and characterization of human taste receptor genes belonging to the TAS2R family.	TAS2R31 TAS2R43 TAS2R46	2.54e-05	13	158	3	12584440
Pubmed	Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus.	SOX4 RELN WLS	5.97e-05	17	158	3	33084572
Pubmed	Malignant struma ovarii: next-generation sequencing of six cases revealed Nras, Braf, and Jak3 mutations.	JAK3 BRAF	6.13e-05	3	158	2	32743766
Pubmed	PSD-95 interacts with NBCn1 and enhances channel-like activity without affecting Na/HCO(3) cotransport.	SLC4A7 GRIN2A	6.13e-05	3	158	2	23183381
Pubmed	Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.	CACNA1B CACNA1C	6.13e-05	3	158	2	26507659
Pubmed	Obstructed migration of Purkinje cells in the developing cerebellum of the reeler mutant mouse.	RELN TNC	6.13e-05	3	158	2	7506500
Pubmed	Derlin-1 promotes the efficient degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR folding mutants.	DERL1 CFTR	6.13e-05	3	158	2	16954204
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	CLSTN3 SLC4A7 BCAS3 POLD1 ZNF205 DNAH14 SLC35A3 RNPEP RIN2 GIGYF2 WDR90 EIF3B WDR1 ADPGK	8.95e-05	925	158	14	28986522
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	LRRN1 COL20A1 CALCOCO1 DNAH2 WDR48	1.11e-04	103	158	5	10819331
Pubmed	A novel family of mammalian taste receptors.	TAS2R31 TAS2R43 TAS2R46	1.15e-04	21	158	3	10761934
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	IRF2BP1 LONP2 SHOC2 MED24 METTL13 AARS2 IRF2BPL EIF3B WDR48	1.15e-04	410	158	9	26949251
Pubmed	Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes.	MFRP BMP2	1.22e-04	4	158	2	16442268
Pubmed	The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3.	SLC4A7 CFTR	1.22e-04	4	158	2	12403779
Pubmed	A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2.	IRF2BP1 IRF2BPL	1.22e-04	4	158	2	21444724
Pubmed	Analysis of CFTR folding and degradation in transiently transfected cells.	DERL1 CFTR	1.22e-04	4	158	2	21594788
Pubmed	EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides.	EPHX2 EPHX4	1.22e-04	4	158	2	22798687
Pubmed	A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C.	CACNA1B CACNA1C	1.22e-04	4	158	2	15728831
Pubmed	Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk.	CACNA1B CACNA1C	1.22e-04	4	158	2	19065143
Pubmed	The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels.	CACNA1C DERL1	1.22e-04	4	158	2	21186355
Pubmed	G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels.	CACNA1B CACNA1C	1.22e-04	4	158	2	15953418
Pubmed	Aberrant trajectory of thalamocortical axons associated with abnormal localization of neurocan immunoreactivity in the cerebral neocortex of reeler mutant mice.	RELN CNTN2	1.22e-04	4	158	2	16324103
Pubmed	Hemicentin-1 is an essential extracellular matrix component of the dermal-epidermal and myotendinous junctions.	TNC HMCN1	1.22e-04	4	158	2	34504132
Pubmed	Evolutionary relationships of the Tas2r receptor gene families in mouse and human.	TAS2R31 TAS2R43 TAS2R46	1.33e-04	22	158	3	12734386
Pubmed	The molecular receptive ranges of human TAS2R bitter taste receptors.	TAS2R31 TAS2R43 TAS2R46	1.52e-04	23	158	3	20022913
Pubmed	Receptors for bitter and sweet taste.	TAS2R31 TAS2R43 TAS2R46	1.97e-04	25	158	3	12139982
Pubmed	Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator.	DERL1 CFTR	2.03e-04	5	158	2	16901789
Pubmed	Modified N-methyl-D-aspartate receptor subunit expression emerges in reeler Purkinje cells after accomplishment of the adult wild-type expression.	RELN GRIN2A	2.03e-04	5	158	2	9004271
Pubmed	Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.	CACNA1B CACNA1C	2.03e-04	5	158	2	11296258
Pubmed	Reelin signaling facilitates maturation of CA1 glutamatergic synapses.	RELN GRIN2A	2.03e-04	5	158	2	17229826
Pubmed	Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis.	EPHX2 EPHX4	2.03e-04	5	158	2	23493561
Pubmed	Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics.	PMS2 BRAF	2.03e-04	5	158	2	17312306
Pubmed	Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons.	RELN CNTN2	2.03e-04	5	158	2	10399933
Pubmed	Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit.	CACNA1B CACNA1C	2.03e-04	5	158	2	16787652
Pubmed	Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.	CACNA1B CACNA1C	2.03e-04	5	158	2	15451373
Pubmed	Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2.	SLC4A7 USH2A	2.03e-04	5	158	2	16301216
Pubmed	Differential expression of phosphacan/RPTPbeta isoforms in the developing mouse visual system.	TNC CNTN2	2.03e-04	5	158	2	17722031
Pubmed	A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease.	NLRP8 NLRP5	2.03e-04	5	158	2	22166940
Pubmed	Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.	COL20A1 TNC SSPOP HMCN1	2.11e-04	64	158	4	22261194
Pubmed	Gamma protocadherins are required for survival of spinal interneurons.	RELN GRIN2A CNTN2	2.21e-04	26	158	3	12467588
Pubmed	Molecular mechanisms of bitter and sweet taste transduction.	TAS2R31 TAS2R43 TAS2R46	2.21e-04	26	158	3	11696554
Pubmed	Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.	RELN SSPOP AIFM3 TMEM181	2.37e-04	66	158	4	15790807
Pubmed	Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.	TAS2R31 TAS2R43 TAS2R46	2.48e-04	27	158	3	12581520
Pubmed	GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis.	TNC WLS BMP2	2.77e-04	28	158	3	28218627
Pubmed	Voltage-gated calcium channels in developing GnRH-1 neuronal system in the mouse.	CACNA1B CACNA1C	3.04e-04	6	158	2	16029198
Pubmed	Phosphodiesterase 10A Is Tethered to a Synaptic Signaling Complex in Striatum.	GRIN2A PDE10A	3.04e-04	6	158	2	25762721
Pubmed	Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin.	CACNA1B CACNA1C	3.04e-04	6	158	2	11438518
Pubmed	Migration of sympathetic preganglionic neurons in the spinal cord of a C3G-deficient mouse suggests that C3G acts in the reelin signaling pathway.	RELN CNTN2	3.04e-04	6	158	2	22351125
Pubmed	Wnt-Dependent Oligodendroglial-Endothelial Interactions Regulate White Matter Vascularization and Attenuate Injury.	WLS BRAF	3.04e-04	6	158	2	33086038
Pubmed	A common variant in DRD3 receptor is associated with autism spectrum disorder.	RELN NPY5R ABCA13 GRIN2A CDK14	3.06e-04	128	158	5	19058789
Pubmed	Adaptive diversification of bitter taste receptor genes in Mammalian evolution.	TAS2R31 TAS2R43 TAS2R46	3.41e-04	30	158	3	12679530
Pubmed	Chromosomal assignments of 23 biochemical loci of the rat by using rat x mouse somatic cell hybrids.	GANC F5 LAP3	3.41e-04	30	158	3	1914521
Pubmed	Expression of Foxm1 transcription factor in cardiomyocytes is required for myocardial development.	SOX4 BMP2 MYOCD	3.77e-04	31	158	3	21779394
Pubmed	Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular Zone Involves the Zeb1 Transcription Factor.	RELN TNC TLX3	4.14e-04	32	158	3	27806288
Pubmed	Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.	DNAH2 DNAH12	4.24e-04	7	158	2	9256245
Pubmed	Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain.	RELN GRIN2A	4.24e-04	7	158	2	21664258
Pubmed	Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes.	CACNA1B CACNA1C	4.24e-04	7	158	2	21057379
Pubmed	BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex.	DERL1 CFTR	4.24e-04	7	158	2	18555783
Pubmed	NMDA-receptor proteins are upregulated in the hippocampus of postnatal heterozygous reeler mice.	RELN GRIN2A	4.24e-04	7	158	2	16438943
Pubmed	Poly (ADP-Ribose) Polymerase 1 Regulates Cajal-Retzius Cell Development and Neural Precursor Cell Adhesion.	RELN TNC	4.24e-04	7	158	2	34708032
Pubmed	Molecular mechanisms of cell and tissue interactions during early tooth development.	TNC BMP2	4.24e-04	7	158	2	8769660
Pubmed	Id4 is required for the correct timing of neural differentiation.	RELN BMP2	4.24e-04	7	158	2	15882580
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TCAF1 LRRN1 CRY2 METTL13 IPO9 AARS2 IRF2BPL NCEH1 FAM135A	4.48e-04	493	158	9	15368895
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CACNA1C CPAMD8 LRRN1 BCAS3 CALCOCO1 OBSCN PDE10A CDK14 SSPOP ITGB5 C2CD2 DNAH14 SLC25A36 SLC35A3 SLC41A3 RIN2 TMEM181	4.59e-04	1489	158	17	28611215
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	CACNA1C DCHS2 ACACB POLD1 OBSCN DNAH12 XIRP2 GIGYF2 KIF2C	4.74e-04	497	158	9	36774506
Pubmed	Evolution of bitter taste receptors in humans and apes.	TAS2R31 TAS2R43 TAS2R46	4.96e-04	34	158	3	15496549
Pubmed	Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing.	ADARB2 BMP2	5.64e-04	8	158	2	27376238
Pubmed	Increased Ca2+ signaling through CaV 1.2 induces tendon hypertrophy with increased collagen fibrillogenesis and biomechanical properties.	CACNA1C TNC	5.64e-04	8	158	2	37261735
Pubmed	RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR).	DERL1 CFTR	5.64e-04	8	158	2	24019521
Pubmed	Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease.	SLC4A7 USH2A	5.64e-04	8	158	2	16545802
Pubmed	Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior.	GRIN2A PRKG2	5.64e-04	8	158	2	18606955
Pubmed	Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.	PMS2 OBSCN TMPRSS12 CRY2 MCRS1	6.14e-04	149	158	5	25184681
Pubmed	Canonical Wnt signaling regulates smooth muscle precursor development in the mouse ureter.	TNC MYOCD UPK3A	6.91e-04	38	158	3	22833126
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	CACNA1B ATP6V0B SLC4A7 INTS1 MPDZ IPO9 ECE2	7.07e-04	322	158	7	26514267
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ACACB IRF2BP1 DERL1 TNC YY2 DNAH2 ELP1 IPO9 DNAH12 MCRS1	7.10e-04	638	158	10	31182584
Pubmed	Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators.	SOX4 SOX15	7.23e-04	9	158	2	12100890
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1B CACNA1C	7.23e-04	9	158	2	16382099
Pubmed	Sudden infant death syndrome: case-control frequency differences at genes pertinent to early autonomic nervous system embryologic development.	TLX3 BMP2	7.23e-04	9	158	2	15240857
Pubmed	Dorsal-to-Ventral Cortical Expansion Is Physically Primed by Ventral Streaming of Early Embryonic Preplate Neurons.	RELN CNTN2	7.23e-04	9	158	2	31693895
Pubmed	Carrier frequency of autosomal-recessive disorders in the Ashkenazi Jewish population: should the rationale for mutation choice for screening be reevaluated?	CFTR ELP1	7.23e-04	9	158	2	18264947
Pubmed	Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508.	DERL1 CFTR	7.23e-04	9	158	2	18216283
Pubmed	Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors.	RELN TNC	7.23e-04	9	158	2	11239431
Pubmed	Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.	CPAMD8 RELN SLC25A36	7.46e-04	39	158	3	19010793
Pubmed	Novel Cul3 binding proteins function to remodel E3 ligase complexes.	WDR90 WDR1 WDR48	8.03e-04	40	158	3	25011449
Pubmed	Human transcription factor protein interaction networks.	SOX4 SOX15 ACACB IRF2BP1 TLX3 YY2 MSANTD2 SRCAP MED24 SLC25A36 GIGYF2 MCRS1 IRF2BPL EIF3B WDR1 WDR48	8.32e-04	1429	158	16	35140242
Pubmed	Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development.	RELN CNTN2	9.01e-04	10	158	2	16407979
Pubmed	Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits.	LRRN1 BCAS3	9.01e-04	10	158	2	19139271
Pubmed	Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos.	TNC BMP2	9.01e-04	10	158	2	15162503
Cytoband	12p13.2	CLEC1A TAS2R31 TAS2R43 TAS2R46	1.85e-05	45	159	4	12p13.2
GeneFamily	Fibronectin type III domain containing	COL20A1 TNC OBSCN CMYA5 ANOS1 CSF3R USH2A CNTN2	6.44e-06	160	111	8	555
GeneFamily	Dyneins, axonemal	DNAH2 DNAH14 DNAH12	1.44e-04	17	111	3	536
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN ABCA13 CFTR OBSCN SSPOP HMCN1 XIRP2 MYOCD USH2A CNTN2	1.29e-09	184	159	10	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN ABCA13 CFTR OBSCN SSPOP HMCN1 XIRP2 MYOCD USH2A CNTN2	1.29e-09	184	159	10	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN ABCA13 CFTR OBSCN SSPOP HMCN1 XIRP2 MYOCD USH2A CNTN2	1.29e-09	184	159	10	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	ACACB OBSCN CMYA5 SLC7A6 RGS6 XIRP2 NCEH1 MYOCD	3.96e-07	188	159	8	0758b474457efa36488e0195f7357100f4b6a090
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN OBSCN ADARB2 ITGB5 ANOS1 RIN2 PRKG2 ECE2	4.29e-07	190	159	8	be2b184a3559da41ba387ae0fdbeb9ae532868a5
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN GRIN2A WLS ADARB2 ITGB5 ANOS1 RIN2 ECE2	4.65e-07	192	159	8	63d1b3efe93e5ff939278ebe40bacb38218ea09b
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1B CACNA1C ABCA13 F5 AIFM3 USH2A PRLR	1.94e-06	162	159	7	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	COVID-19-Heart-CM_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1C OBSCN CMYA5 RGS6 NALCN XIRP2 MYOCD	4.51e-06	184	159	7	e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	ACACB OBSCN CMYA5 SLC25A36 XIRP2 NCEH1 MYOCD	5.01e-06	187	159	7	78cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	CACNA1C ACACB OBSCN CMYA5 XIRP2 NCEH1 MYOCD	5.38e-06	189	159	7	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN WLS ADARB2 ITGB5 ANOS1 RIN2 PRKG2	5.38e-06	189	159	7	979b7fa947538aa7ca4a219263da2575869a2caa
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN OBSCN ADARB2 ITGB5 ANOS1 PRKG2 ECE2	5.57e-06	190	159	7	3b8d1e66ae68c1eee64095e75195d76d97e24026
ToppCell	COVID-19-Heart\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1C OBSCN CMYA5 PDE10A RGS6 XIRP2 MYOCD	5.57e-06	190	159	7	918ad5037881212008f9f69d5df5da91fd01422c
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN OBSCN ADARB2 ITGB5 ANOS1 PRKG2 ECE2	5.57e-06	190	159	7	dc655e4782aab274f0c9b6e36a5ce315e3a1a4b9
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC4A7 LRRN1 WLS CRY2 USH2A FAM135A PRLR	5.96e-06	192	159	7	5b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN WLS ADARB2 ITGB5 BMP2 ANOS1 ECE2	5.96e-06	192	159	7	f6ec683b2133b3095a1fcc06ca8605cf38f774b5
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	ACACB OBSCN CMYA5 SLC7A6 RGS6 NCEH1 MYOCD	5.96e-06	192	159	7	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN ADARB2 ITGB5 ANOS1 RIN2 PRKG2 ECE2	5.96e-06	192	159	7	342842378c20267c5044bdd622515e8b9f895623
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN ADARB2 ITGB5 ANOS1 RIN2 PRKG2 ECE2	5.96e-06	192	159	7	bd3fa6c8fcb618db64d11f25cabaf08608957c35
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN WLS ADARB2 ITGB5 BMP2 ANOS1 ECE2	5.96e-06	192	159	7	690b3d17c481159bc96b8bc7f6a66b51343ee858
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN WLS ADARB2 ITGB5 BMP2 ANOS1 ECE2	6.38e-06	194	159	7	6ac759828c41ffa974ee82842162caa959351dd1
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN WLS ADARB2 ITGB5 BMP2 ANOS1 ECE2	6.38e-06	194	159	7	5d0b0d8e96f0e0297a4dba70a05d87081a4eb323
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN ADARB2 ITGB5 ANOS1 RIN2 PRKG2 ECE2	6.60e-06	195	159	7	98ca9f3aa36211dde1e6f7f3817b9418c95e583e
ToppCell	Neuronal-Inhibitory-iA-iA_2(LAMP5)-LCP2--L1-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RELN ADARB2 ITGB5 ANOS1 RIN2 PRKG2 ECE2	7.78e-06	200	159	7	f268cb1bb047e88913a828614b0a77871f5f8814
ToppCell	Neuronal-Inhibitory-iA-iA_2(LAMP5)-LCP2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RELN ADARB2 ITGB5 ANOS1 RIN2 PRKG2 ECE2	7.78e-06	200	159	7	5ff9ac97ef970b3b74ebb07f62a0a1f4176a10b4
ToppCell	Neuronal-Inhibitory-iA-iA_2(LAMP5)-LCP2-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RELN ADARB2 ITGB5 ANOS1 RIN2 PRKG2 ECE2	7.78e-06	200	159	7	7345cc7dc24b9174541a3e68ecac8c4c092be400
ToppCell	COVID-19-kidney-Technical/muscle_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	CNBD1 RELN ABCA13 DNAH2 GRIN2A USH2A	1.43e-05	146	159	6	c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1B CNBD1 RELN SI TRIM64 USH2A	1.67e-05	150	159	6	0205318a870e091add66ee4305747dda9f51510d
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TNC CMYA5 SRCAP BMP2 TAS2R31 TAS2R46	2.08e-05	156	159	6	bb505f639dbcad2b788db62d6084c2cb4e884bec
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	IRF2BP1 YY2 MPDZ ERP27 EPHX4 VAT1	2.40e-05	160	159	6	8bb873704895c3b35bba8af78fedbabf7df42e71
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-plasma_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RELN COL20A1 PPP3CC UPK3A PRLR KIF2C	2.76e-05	164	159	6	b92e7c91910d518627376166c6ea9ed333b3d07e
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-plasma_cell-plasma_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RELN COL20A1 PPP3CC UPK3A PRLR KIF2C	2.76e-05	164	159	6	a1e43c6b3e2553f5604100db6e92bf244b70c36d
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	IRF2BP1 YY2 MPDZ ERP27 EPHX4 VAT1	3.26e-05	169	159	6	b66ffc2b2b6bfcc3a6e639d9d31d3de95f4a94e1
ToppCell	COVID-19-Heart-CM_3\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1C OBSCN CMYA5 PDE10A XIRP2 MYOCD	4.09e-05	176	159	6	9df7a124ebafb0087da0cda133a394275d7bed81
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	CACNA1C OBSCN CMYA5 PDE10A XIRP2 MYOCD	4.93e-05	182	159	6	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	COVID-19-Heart-CM_4\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1C CMYA5 F5 RGS6 XIRP2 MYOCD	5.08e-05	183	159	6	2902b6e8aa9a6f62bc1a792c971ab7f651a8e676
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LRRN1 TNC GPR143 PDE10A NALCN MYOCD	5.08e-05	183	159	6	7eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-Tuft-related-Microfold_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA13 POLD1 DENND11 GLRA2 NCEH1 PADI1	5.08e-05	183	159	6	9a2cd63af5f492d46ce80ca1536312e8ac0e7df4
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TCAF1 LRRN1 TNC GPR143 NALCN MYOCD	5.08e-05	183	159	6	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	CACNA1C ACACB OBSCN CMYA5 XIRP2 MYOCD	5.24e-05	184	159	6	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1C OBSCN CMYA5 RGS6 XIRP2 MYOCD	5.40e-05	185	159	6	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TCAF1 LRRN1 TNC GPR143 NALCN MYOCD	5.40e-05	185	159	6	6712512100ccef456d2e2bd201d0987986c92ac9
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	CACNA1C OBSCN CMYA5 XIRP2 NCEH1 MYOCD	5.40e-05	185	159	6	6baccb26f999145e51b91d94315bf8d4655bef31
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SOX4 RELN ADARB2 BMP2 ANOS1 ECE2	5.56e-05	186	159	6	310d16f4e5cffee3ea6d7635508c513a3b92131e
ToppCell	Control-Endothelial-Endothelial-Vein\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CLSTN3 PDE10A F5 BMP2 HMCN1 PRLR	5.56e-05	186	159	6	92092f11ecce22c14f244e42c499af0822977e6f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SOX4 RELN WLS ADARB2 BMP2 ANOS1	5.90e-05	188	159	6	0501a8aa850bd2e347020abd1cac4d8075738189
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|RV / Chamber and Cluster_Paper	OBSCN CMYA5 SLC25A36 RGS6 NCEH1 MYOCD	6.08e-05	189	159	6	9c1debd65c13d63fd4f3158917d621b44b714c26
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	CACNA1C ACACB OBSCN CMYA5 RGS6 NCEH1	6.26e-05	190	159	6	de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC4A7 ACACB SRCAP ITGB5 C2CD2 ADPGK	6.26e-05	190	159	6	63018acb7ad80415e861643162abdc2e55968ee4
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	CACNA1C ACACB OBSCN CMYA5 RGS6 MYOCD	6.26e-05	190	159	6	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SOX4 RELN ADARB2 BMP2 ANOS1 ECE2	6.44e-05	191	159	6	fa50a3c7ff86e1ee07100da1ace0b0fa1b0ab26b
ToppCell	human_hepatoblastoma-Tumor_cells-T8\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ACACB GANC F5 CRY2 CSF3R PRLR	6.63e-05	192	159	6	e785135262f4c9cc66c403bf362bb34643b212c5
ToppCell	IPF-Epithelial-Club\|Epithelial / Disease state, Lineage and Cell class	SOX4 CPAMD8 SLC4A7 CFTR CDK14 HMCN1	6.63e-05	192	159	6	356e7a820b744a0ac87352a8d0e6e8d9fa9ed7d2
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-stromal_related-FDC\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPHX2 C2CD2 LAP3 HMCN1 CSF3R NCEH1	7.02e-05	194	159	6	f9fbb043411546d8c9e0321a64165d411f44aeb7
ToppCell	RA-03._Atrial_Cardiomyocyte\|RA / Chamber and Cluster_Paper	CACNA1C ACACB OBSCN CMYA5 RGS6 MYOCD	7.02e-05	194	159	6	c3535f7cc0076653c72db582047cff053c322397
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ABCA13 PDE10A F5 DNAH14 HMCN1 CSF3R	7.22e-05	195	159	6	d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ABCA13 PDE10A F5 DNAH14 HMCN1 CSF3R	7.22e-05	195	159	6	19853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell	background-Hepatic_Stellate_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	CACNA1C TNC PKDCC ANOS1 HMCN1 NALCN	7.86e-05	198	159	6	bd11b0e9e80449aab979a02c1023e0638c431c7c
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-NPM1P10\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CNBD1 TLX3 WLS PELO VWA5A PRKG2	8.31e-05	200	159	6	7b3284bf0000e14f5a51e4422231e5639a184579
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-NPM1P10-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CNBD1 TLX3 WLS PELO VWA5A PRKG2	8.31e-05	200	159	6	e957f5926675f6c29208cfc3203a19dab538df38
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-NPM1P10--L5-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CNBD1 TLX3 WLS PELO VWA5A PRKG2	8.31e-05	200	159	6	2ea33ac1970791e6a601ac1e407ef32e4833792d
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal-GABAergic_neurons\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	SOX4 RELN OBSCN WLS CDK14 ADARB2	8.31e-05	200	159	6	c6bbd33bca86ac7a76a7ba704b3e141237d04549
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CPAMD8 ABCA2 GPR143 ANOS1 MSS51	9.65e-05	128	159	5	2cf0384240a4a663869cf6b27d954236f6214a9a
ToppCell	COVID-19-kidney-Technical/muscle_(EC)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1B CNBD1 RELN TRIM64B USH2A	9.65e-05	128	159	5	91072ca56bce2c552a95edd67e17f43d8cc1de95
ToppCell	LV-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	CACNA1C PLA2G3 CMYA5 SLC25A36 XIRP2	1.04e-04	130	159	5	a3e12984fb61311e49cc76c59f74f4dffc48faa1
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Krt73\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RELN ABCA13 TNC ADARB2 VWA5A	1.08e-04	131	159	5	9ca209a8652aae603c4a867ea06b06ac51e7d189
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Gpc3_Slc18a3\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NPY5R CFTR F5 ADARB2 GLRA2	1.33e-04	137	159	5	d346086f42d8f04d3fa67fe696834284acdc7080
Disease	Colorectal Carcinoma	CPAMD8 CLSTN3 PMS2 ABCA13 POLD1 CFTR OBSCN GRIN2A F5 ADARB2 BMP2 BRAF MCRS1 NLRP8	1.19e-05	702	147	14	C0009402
Disease	neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures (implicated_via_orthology)	IRF2BP1 IRF2BPL	7.37e-05	3	147	2	DOID:0081327 (implicated_via_orthology)
Disease	N6,N6,N6-trimethyllysine measurement	SLC7A6 SLC25A45	2.44e-04	5	147	2	EFO_0800126
Disease	Myeloid Leukemia, Chronic	CRY2 BRAF CSF3R	4.03e-04	29	147	3	C0023473
Disease	Colorectal Neoplasms	CPAMD8 ABCA13 POLD1 CFTR GRIN2A BMP2 BRAF	4.96e-04	277	147	7	C0009404
Disease	Bipolar Disorder	CACNA1B CACNA1C RELN ABCA13 GRIN2A PDE10A CRY2 PPP3CC BRD1	6.74e-04	477	147	9	C0005586
Disease	Autism Spectrum Disorders	EPHX2 RELN GLRA2 USH2A	8.75e-04	85	147	4	C1510586
Disease	Lymphoma	JAK3 BRAF CSF3R	1.05e-03	40	147	3	C0024299
Disease	interleukin 2 measurement	BCAS3 ADARB2 ITGB5	1.12e-03	41	147	3	EFO_0008331
Disease	ejection fraction measurement	PMS2 ADARB2 HMCN1	1.29e-03	43	147	3	EFO_0005527
Disease	Noonan Syndrome 1	SHOC2 BRAF	1.32e-03	11	147	2	C4551602
Disease	Turner Syndrome, Male	SHOC2 BRAF	1.32e-03	11	147	2	C0041409
Disease	Female Pseudo-Turner Syndrome	SHOC2 BRAF	1.32e-03	11	147	2	C1527404
Disease	Ashkenazi Jewish disorders	CFTR ELP1	1.32e-03	11	147	2	cv:CN118946
Disease	Cystic Fibrosis	CLCA4 CFTR	1.32e-03	11	147	2	C0010674
Disease	melanoma	TNC SLC35G2 GRIN2A MTAP BRAF SLC25A45	1.56e-03	248	147	6	C0025202
Disease	developmental disorder of mental health (implicated_via_orthology)	GRIN2A SRCAP GIGYF2	1.89e-03	49	147	3	DOID:0060037 (implicated_via_orthology)
Disease	RASopathy	SHOC2 BRAF	2.48e-03	15	147	2	cv:C5555857
Disease	central nervous system disease (implicated_via_orthology)	IRF2BP1 IRF2BPL	2.83e-03	16	147	2	DOID:331 (implicated_via_orthology)
Disease	executive function measurement	CACNA1C TLX3 DPPA2 GRIN2A ADARB2 METTL13 ERP27	2.86e-03	376	147	7	EFO_0009332
Disease	cortical surface area measurement	CNBD1 DCHS2 CPAMD8 RELN STK17B TLX3 PKDCC MARCHF7 AGBL5 WLS ITGB5 BMP2 WDR1 BRD1 PRLR	2.99e-03	1345	147	15	EFO_0010736
Disease	adverse effect, response to xenobiotic stimulus	ABCA2 ADARB2 MTAP	3.21e-03	59	147	3	EFO_0009658, GO_0009410
Disease	obsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa	EPHX2 CACNA1C GRIN2A RGS6 BRAF	3.34e-03	200	147	5	EFO_0003756, EFO_0003761, EFO_0003888, EFO_0004242, EFO_0004895, MONDO_0004985, MONDO_0005090, MONDO_0005351
Disease	Noonan-Like Syndrome With Loose Anagen Hair	SHOC2 BRAF	3.99e-03	19	147	2	C3501846
Disease	Noonan syndrome-like disorder with loose anagen hair	SHOC2 BRAF	3.99e-03	19	147	2	C1843181
Disease	Cardio-facio-cutaneous syndrome	SHOC2 BRAF	3.99e-03	19	147	2	C1275081
Disease	Costello syndrome (disorder)	SHOC2 BRAF	3.99e-03	19	147	2	C0587248
Disease	Schizophrenia	EPHX2 CACNA1B CACNA1C RELN ABCA13 GRIN2A CMYA5 PPP3CC RCBTB1 MSS51 BRD1	4.81e-03	883	147	11	C0036341

Protein segments in the cluster

Peptide	Gene	Start	Entry
SVWIMPQQSAGLEES	AGBL5	401	Q8NDL9
EQLSGSILWMAPEVI	BRAF	611	P15056
MWISTDAAASVLEPL	BRD1	916	O95696
WNGVPDVGMVSDILF	ADPGK	346	Q9BRR6
LYIVSNMSSVPWEGS	DPEP2NB	6	A0A0U1RQF7
MKETIIAFAWEPNGS	EIF3B	561	P55884
EVPDGFTAVMSASTW	RNPEP	196	Q9H4A4
DMESIPAVTTWNTYL	CFTR	836	P13569
FWDDSALTIIVNPME	CLSTN3	896	Q9BQT9
LAQEAEMSTVPYLWT	AIFM3	501	Q96NN9
EETWSSGNPIMTFLS	ABCA13	3046	Q86UQ4
LVEVMHPSFGFSWVL	ADCK5	251	Q3MIX3
LWELTDMSSIFTVPN	CDK14	426	O94921
MQVWSIPISGEAQEL	BCAS3	101	Q9H6U6
SFDVTPAVMRWTAQG	BMP2	206	P12643
LTLFTVSTGEGWPMV	CACNA1B	1356	Q00975
SWSEMASIKVGQFPL	MROH7	376	Q68CQ1
GMSWTPAETNALIAV	MSANTD2	101	Q6P1R3
EVTQTAAFWQMDGPL	RCBTB1	501	Q8NDN9
FRTWGADVINMTTVP	MTAP	186	Q13126
TLFTDTVGFRMAPWI	PADI1	281	Q9ULC6
PFSMNWVVGSADLEI	ADARB2	636	Q9NS39
IPSVVTGTDIVQWLM	RGS6	56	P49758
FGATVWEVFSGVTMP	JAK3	711	P52333
WEVFSGVTMPISALD	JAK3	716	P52333
SSMFWVVAEPTLLGQ	OOSP3	31	A0A2R8YFM6
FKEIMAPWAQTVVTG	ACACB	2071	O00763
PKSWIEEQAMGSFLS	LAP3	236	P28838
TTAFPNIWVGMITQE	MFRP	481	Q9BY79
PMTGFQVTWAEVTTE	ANOS1	581	P23352
AWTPLGGEIMFVEAS	LONP2	661	Q86WA8
FTEEGETPAWLEQMI	NELFCD	136	Q8IXH7
VWSLEPEDLSAVTME	GK3P	471	Q14409
QSMPWLADLVQSSEG	INTS1	886	Q8N201
WGVINVEQSSVFLMP	ITGB1BP2	271	Q9UKP3
LWLPDTTGEIVMTQS	IGKV3D-7	16	A0A0C4DH55
MEWLLVTGDFVLPSG	MSS51	161	Q4VC12
LTELSTGTMPITWDQ	NLRP8	61	Q86W28
TTPTLLLWGENDAFM	EPHX4	296	Q8IUS5
NQILWFDSTDGTFMP	ERVMER34-1	146	Q9H9K5
SISELQALAPSMDWL	ECE2	376	P0DPD6
SVTEDLDAPWMGIQN	FAM135A	416	Q9P2D6
VPWAFMQGEIATILA	IRF2BPL	771	Q9H1B7
CTSEEWQGLMQFTLP	PDE10A	441	Q9Y233
MIFTSWPTNFSVGIR	NCEH1	381	Q6PIU2
MASWLPETLFETVGQ	FBXO36	1	Q8NEA4
GSTDILFLWNDMNEP	GANC	501	Q8TET4
MSDIGDWFRSIPAIT	DERL1	1	Q9BUN8
FDGPIDTLWIESMNT	DNAH12	1616	Q6ZR08
TGMQPCAFWTDAITI	PNPLA1	176	Q8N8W4
MGDKPIWEQIGSSFI	NUTF2	1	P61970
ISVWPGYLETMQSSL	POLG2	411	Q9UHN1
GISVMSWSPDQELVL	ELP1	111	O95163
TAADWPEMQTLAGAF	NLRP5	256	P59047
GLVSSMEFPWVVSLQ	PRSS54	46	Q6PEW0
SAGWDVIQMTPQEIA	ITGB5	101	P18084
LLSSIPMWTTFGELA	PRKG2	221	Q13237
NGLQLSFTESPWETM	MYOCD	876	Q8IZQ8
DLTPTEGWIMQFKIS	RELN	2746	P78509
PKIAWTVNDMFIVGS	HMCN1	641	Q96RW7
ASVSEAAAPGTVVMW	DCHS2	546	Q6V1P9
AAAPGTVVMWVSASD	DCHS2	551	Q6V1P9
GVAVWDVVMEAPSQS	ITGAD	976	Q13349
PQTDIWAIGVTAFIM	OBSCN	7846	Q5VST9
GEITLSQWIPLMEEN	EPHX2	56	P34913
VWQQSVPEGMVTSLD	DSCC1	291	Q9BVC3
LQISWSFISVPEMAV	C2CD2	176	Q9Y426
MALFTVSTFEGWPEL	CACNA1C	1126	Q13936
MAAETQTLNFGPEWL	GIGYF2	1	Q6Y7W6
EGKTGFPWIDAIMTQ	CRY2	351	Q49AN0
VPADMVFLVDGSWSI	COL20A1	176	Q9P218
QALFRVATTEMEPGW	EPM2AIP1	581	Q7L775
FVVTFDPRSGNMVEW	DENND11	81	A4D1U4
VWVMAVNFTGCSLPS	CMYA5	3781	Q8N3K9
SDQPVLGEWFIFVEM	CPAMD8	196	Q8IZJ3
VWLGFPNFVDSVSDM	GPR143	91	P51810
GVWSLEPEDLSAVTM	GK	476	P32189
SPFEWDIVTRGLVAM	ABCA2	1981	Q9BZC7
NAETAQVLGLTPWMD	CNTN2	666	Q02246
GSWVPTIMEEDAFQL	CSF3R	671	Q99062
DPNTMEWTDGLLSAT	DNAH14	1491	Q0VDD8
FSMPVKFENGTWVVL	MDH1B	416	Q5I0G3
TMNDLIFEWLSDGPV	GLRA2	196	P23416
WQVLVDSITGMSSPD	MCRS1	326	Q96EZ8
MITVDIIPSGWNSAD	MARCHF7	501	Q9H992
TWLTDVPAAMEFIAA	ERP27	41	Q96DN0
TGKPALEFVMAEWTS	IPO9	831	Q96P70
IDGNPETFWTTTGMF	HSPB11	31	Q9Y547
ETFWTTTGMFPQEFI	HSPB11	36	Q9Y547
DPSMLEVATQWFGFS	METTL13	526	Q8N6R0
FDGPVDTLWIENMNS	DNAH2	2166	Q9P225
EFQSFMPWDIAILVG	SLC13A1	426	Q9BZW2
MPSASDWIGIFKVEA	CALCOCO1	41	Q9P1Z2
WSTFIRIMDPDVITG	POLD1	381	P28340
IQQGPDWLELSEMTE	KIF2C	656	Q99661
EVITSAPGAMLASWA	DPPA2	176	Q7Z7J5
GSSVPWAFMQGEIAT	IRF2BP1	556	Q8IU81
WFDSTPNLEILMIGE	LRRN1	186	Q6UXK5
STTSVPRMLGIFWFD	OR52J3	76	Q8NH60
MISVWSFGSLENKPV	TAS2R31	246	P59538
MISVWSFGSLENKPV	TAS2R43	246	P59537
IMSVWSFESLENKPV	TAS2R46	246	P59540
AWVSERTGESAPVFM	USH2A	1351	O75445
TPEVSEMISGDWLES	SOX4	451	Q06945
SVMGLPWFVAATVLS	SLC4A7	966	Q9Y6M7
GAPVEMIQLLQTSWE	PKDCC	236	Q504Y2
DDLDPAVWTFGRMVQ	SSPOP	2186	A2VEC9
LMNGVTSWDVPEDAV	TCAF1	11	Q9Y4C2
DLNQTLPSMDFGWIA	F5	1081	P12259
TIWGISTMFILQEPI	SLC35G2	296	Q8TBE7
PFTLTSVLLDQWMFG	NPY5R	96	Q15761
SSAAALWMEEGLPAQ	ENTPD4	596	Q9Y227
SRTGAEVPFFETWMQ	MED24	516	O75448
PITTATDMWNIGIIA	STK17B	211	O94768
MLGPWANSTISLTEE	SIGLECL1	61	Q8N7X8
LTSLPLDFGTWTSMV	SHOC2	391	Q9UQ13
AMAGFTAITATNPIW	SLC25A36	126	Q96CQ1
TTWSIGLQVTVPFMF	SLC41A3	61	Q96GZ6
PAWSADVAAVVMQEG	PELO	131	Q9BRX2
WDVSVNSVVSTFPMG	WDR1	261	O75083
LWIDMNEPSSFVNGT	SI	1391	P14410
VPSSELQIYTWMDAT	SAP18	51	O00422
WFSNPLTGMIEGSQE	SRCAP	806	Q6ZRS2
PEVTNMLWELLGTTC	PLA2G3	411	Q9NZ20
QGAMPTFTAEAWALA	AARS2	931	Q5JTZ9
LESWALSQVAGMPVF	SDSL	21	Q96GA7
QVSEPFMESWGEESL	SLFNL1	11	Q499Z3
WSTFGTLEVMPQNES	CNBD1	261	Q8NA66
WMDGTPFTSELFHII	CLEC1A	211	Q8NC01
SLWDPSGTIMENFTV	CLCA4	531	Q14CN2
LMTSTPAWIGLFFDA	CLEC20A	61	Q6ZU45
YTTWMFETQPIDTLG	XIRP2	441	A4UGR9
FTWSLPFVGEKVTEM	PPP3CC	346	P48454
DIMGQDFVPSIGWLV	TIGD3	111	Q6B0B8
LEELAQMGLNFWSSP	RIN2	201	Q8WYP3
MALPGSSQDQAWSLE	SOX15	1	O60248
VDWLSFPMPATTETQ	WDR90	1616	Q96KV7
VPNWFSVDLKTGMLT	WDR48	416	Q8TAF3
SLFWAGVMSAIELVP	TRDV2	11	A0JD36
GQSTEEVQAPLAMWE	MPDZ	681	O75970
MPVEEFVAGWISGAL	SLC25A45	1	Q8N413
VNSWLPGMLDDLFQS	TMEM181	371	Q9P2C4
NGFNPTWEETLVFMV	PLCH2	811	O75038
LTETSPFMWSNLGIG	ATP6V0B	41	Q99437
VKTLEGEFSVTMWSP	YY2	176	O15391
VPDMGNLTVTEVSWD	TNC	1256	P24821
PESFNLSWMATDGIF	TNC	1451	P24821
IPSDFTMNDTTVWIS	PRLR	226	P16471
MSTGLVEDQTLWSDP	UPK3A	171	O75631
DASDPLMWTAVIGTN	TMPRSS12	126	Q86WS5
IMAAQPAELVDSSGW	VWA5A	711	O00534
TLASGVDFPQVSAWM	SNHG28	171	P0DPA3
TVSSLGGLNFPWMES	TLX3	116	O43711
WTFGPQDVDELIFML	PMS2	776	P54278
QTFGMFSWTIPIAVA	SLC7A6	311	Q92536
GMWQEEVTVPSVQTF	VAT1	141	Q99536
LTAWSQMPVTFEDVA	ZNF205	116	O95201
ILMTGVAFVQWPSDS	SLC35A3	146	Q9Y2D2
SMTFINIPVEWFSIG	WLS	276	Q5T9L3
NPELTSWCITGVLDM	TRIM64	266	A6NGJ6
FSRVTAVAIPGWMEV	nan	121	Q6ZS46
NPELTSWCITGVLDM	TRIM64B	266	A6NI03
PMLQEDFWISTALVE	ZFYVE26	941	Q68DK2
LQGTDFMPDPSSEWL	XKR8	246	Q9H6D3
VFEIADIVDQMSPWG	NALCN	126	Q8IZF0
PSAFLEPFSASVWVM	GRIN2A	546	Q12879