Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontRNA-4-demethylwyosine synthase activity

TYW1B TYW1

1.75e-052842GO:0102521
GeneOntologyMolecularFunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

TOP2A TOP2B

1.04e-044842GO:0003918
GeneOntologyMolecularFunctionmetallocarboxypeptidase activity

CPA4 NAALAD2 FOLH1

2.96e-0431843GO:0004181
GeneOntologyMolecularFunctionoxo-acid-lyase activity

TYW1B TYW1

3.62e-047842GO:0016833
GeneOntologyMolecularFunctionDNA topoisomerase activity

TOP2A TOP2B

4.82e-048842GO:0003916
GeneOntologyBiologicalProcesspositive regulation of single stranded viral RNA replication via double stranded DNA intermediate

TOP2A TOP2B

1.64e-052842GO:0045870
GeneOntologyBiologicalProcessregulation of single stranded viral RNA replication via double stranded DNA intermediate

SETDB1 TOP2A TOP2B

6.02e-0519843GO:0045091
GeneOntologyBiologicalProcesssingle stranded viral RNA replication via double stranded DNA intermediate

SETDB1 TOP2A TOP2B

7.07e-0520843GO:0039692
DomainLipase/vitellogenin

PNLIPRP1 PNLIPRP2 LIPI

1.07e-0510853IPR013818
DomainTAG_lipase

PNLIPRP1 PNLIPRP2 LIPI

1.07e-0510853IPR000734
DomainLipase_LIPH

PNLIPRP1 PNLIPRP2 LIPI

1.07e-0510853IPR016272
DomainLipase

PNLIPRP1 PNLIPRP2 LIPI

1.07e-0510853PF00151
DomainLipase_N

PNLIPRP1 PNLIPRP2 LIPI

1.07e-0510853IPR033906
DomainDNA_topoisoIV

TOP2A TOP2B

2.05e-052852PF00521
DomainTopo_IIA_A/C_ab

TOP2A TOP2B

2.05e-052852IPR013758
DomainTopo_IIA_A_a

TOP2A TOP2B

2.05e-052852IPR013757
DomainTopo_IIA_cen_dom

TOP2A TOP2B

2.05e-052852IPR013759
Domain-

TOP2A TOP2B

2.05e-0528523.40.50.670
DomainDTHCT

TOP2A TOP2B

2.05e-052852IPR012542
DomainTOP4c

TOP2A TOP2B

2.05e-052852SM00434
DomainTOP2c

TOP2A TOP2B

2.05e-052852SM00433
DomainTopo_IIA-like_dom

TOP2A TOP2B

2.05e-052852IPR013760
DomainCell_morpho_N

FRY FRYL

2.05e-052852IPR025614
DomainTopo_IIA_bsu_dom2

TOP2A TOP2B

2.05e-052852IPR013506
DomainDTHCT

TOP2A TOP2B

2.05e-052852PF08070
DomainDNA_gyraseB

TOP2A TOP2B

2.05e-052852PF00204
DomaintRNA_wybutosine-synth

TYW1B TYW1

2.05e-052852IPR013917
Domain-

TOP2A TOP2B

2.05e-0528521.10.268.10
DomainMOR2-PAG1_mid

FRY FRYL

2.05e-052852IPR029473
DomainTOPRIM_C

TOP2A TOP2B

2.05e-052852IPR031660
DomainTOPRIM_C

TOP2A TOP2B

2.05e-052852PF16898
Domain-

TOP2A TOP2B

2.05e-0528523.90.199.10
DomainMOR2-PAG1_mid

FRY FRYL

2.05e-052852PF14228
DomainMOR2-PAG1_C

FRY FRYL

2.05e-052852PF14225
DomainMOR2-PAG1_N

FRY FRYL

2.05e-052852PF14222
DomainTopoIIA_CS

TOP2A TOP2B

2.05e-052852IPR018522
DomainWyosine_form

TYW1B TYW1

2.05e-052852PF08608
DomainCell_Morphogen_C

FRY FRYL

2.05e-052852IPR025481
DomainTopo_IIA_A/C

TOP2A TOP2B

2.05e-052852IPR002205
DomainTopo_IIA

TOP2A TOP2B

2.05e-052852IPR001241
DomainTOPOISOMERASE_II

TOP2A TOP2B

2.05e-052852PS00177
Domain-

TOP2A TOP2B

6.12e-0538523.30.1360.40
DomainArg_repress_C-like

TOP2A TOP2B

6.12e-053852IPR024946
DomainToprim_domain

TOP2A TOP2B

1.22e-044852IPR006171
DomainToprim

TOP2A TOP2B

1.22e-044852PF01751
DomainTOPRIM

TOP2A TOP2B

1.22e-044852PS50880
DomainLipase_panc

PNLIPRP1 PNLIPRP2

1.22e-044852IPR002331
DomainLIPASE_SER

PNLIPRP1 PNLIPRP2 LIPI

2.19e-0426853PS00120
DomainHTH_motif

DBX2 DLX1 DLX6 EN2

2.76e-0469854IPR000047
DomainTFR_dimer

NAALAD2 FOLH1

3.03e-046852PF04253
Domain-

NAALAD2 FOLH1

3.03e-0468521.20.930.40
DomainTFR-like_dimer_dom

NAALAD2 FOLH1

4.24e-047852IPR007365
DomainFLAVODOXIN_LIKE

TYW1B TYW1

5.63e-048852PS50902
DomainFlavodoxin/NO_synth

TYW1B TYW1

5.63e-048852IPR008254
DomainFlavdoxin-like

TYW1B TYW1

5.63e-048852IPR001094
DomainFlavodoxin_1

TYW1B TYW1

5.63e-048852PF00258
DomainrSAM

TYW1B TYW1

7.22e-049852IPR007197
DomainRadical_SAM

TYW1B TYW1

7.22e-049852PF04055
DomainHomeobox_metazoa

DBX2 DLX1 DLX6 EN2

7.58e-0490854IPR020479
DomainFlavoprotein-like_dom

TYW1B TYW1

9.00e-0410852IPR029039
Domain-

TYW1B TYW1

9.00e-04108523.40.50.360
DomainPeptidase_M28

NAALAD2 FOLH1

1.31e-0312852IPR007484
DomainPeptidase_M28

NAALAD2 FOLH1

1.31e-0312852PF04389
DomainHomeobox_CS

LHX2 DBX2 DLX1 DLX6 EN2

1.60e-03186855IPR017970
DomainPropept_inh

CPA4 PCSK4

2.66e-0317852IPR009020
DomainLH2

PNLIPRP1 PNLIPRP2

2.99e-0318852SM00308
DomainHATPase_c

TOP2A TOP2B

2.99e-0318852SM00387
DomainHATPase_c

TOP2A TOP2B

3.33e-0319852PF02518
DomainPA

NAALAD2 FOLH1

3.33e-0319852PF02225
DomainPA_domain

NAALAD2 FOLH1

3.33e-0319852IPR003137
DomainApc4_WD40_dom

WDR36 WDR17

3.69e-0320852IPR024977
DomainANAPC4_WD40

WDR36 WDR17

3.69e-0320852PF12894
Domain-

TOP2A TOP2B

3.69e-03208523.30.565.10
DomainPLAT

PNLIPRP1 PNLIPRP2

4.06e-0321852PS50095
Domain-

TOP2A TOP2B

4.06e-03218523.30.230.10
Domain-

PNLIPRP1 PNLIPRP2

4.06e-03218522.60.60.20
DomainPLAT

PNLIPRP1 PNLIPRP2

4.06e-0321852PF01477
DomainHATPase_C

TOP2A TOP2B

4.06e-0321852IPR003594
DomainPLAT/LH2_dom

PNLIPRP1 PNLIPRP2

4.06e-0321852IPR001024
DomainHomeobox

LHX2 DBX2 DLX1 DLX6 EN2

4.30e-03234855PF00046
DomainRibosomal_S5_D2-typ_fold_subgr

TOP2A TOP2B

4.46e-0322852IPR014721
DomainHOMEOBOX_1

LHX2 DBX2 DLX1 DLX6 EN2

4.46e-03236855PS00027
DomainHOX

LHX2 DBX2 DLX1 DLX6 EN2

4.54e-03237855SM00389
Pubmed

Expression of Dlx and Lhx family homeobox genes in fetal thymus and thymocytes.

LHX2 DLX1 DLX6

3.27e-061287315053981
Pubmed

Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons.

LHX2 DLX1 DLX6

3.27e-06128739247261
Pubmed

DNA topoisomerase II is dispensable for oocyte meiotic resumption but is essential for meiotic chromosome condensation and separation in mice.

TOP2A TOP2B

6.19e-06287224048577
Pubmed

Topoisomerase II alpha and topoisomerase II beta genes: characterization and mapping to human chromosomes 17 and 3, respectively.

TOP2A TOP2B

6.19e-0628721309226
Pubmed

Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.

TOP2A TOP2B

6.19e-06287219222228
Pubmed

Evidence for a mutant allele of the gene for DNA topoisomerase II in adriamycin-resistant P388 murine leukemia cells.

TOP2A TOP2B

6.19e-0628722555055
Pubmed

Characterization of cDNA encoding the mouse DNA topoisomerase II that can complement the budding yeast top2 mutation.

TOP2A TOP2B

6.19e-0628721331984
Pubmed

Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs.

TYW1B TYW1

6.19e-06287216162496
Pubmed

Doxorubicin-induced cardiotoxicity is maturation dependent due to the shift from topoisomerase IIα to IIβ in human stem cell derived cardiomyocytes.

TOP2A TOP2B

6.19e-06287231106979
Pubmed

A biochemical analysis of topoisomerase II alpha and beta kinase activity found in HIV-1 infected cells and virus.

TOP2A TOP2B

6.19e-06287216091284
Pubmed

Kinetic analysis of human topoisomerase IIalpha and beta DNA binding by surface plasmon resonance.

TOP2A TOP2B

6.19e-06287214596941
Pubmed

Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity.

TOP2A TOP2B

6.19e-06287217361331
Pubmed

Molecular cloning and characterization of the human topoisomerase IIalpha and IIbeta genes: evidence for isoform evolution through gene duplication.

TOP2A TOP2B

6.19e-06287210095062
Pubmed

Functional compatibility between isoform alpha and beta of type II DNA topoisomerase.

TOP2A TOP2B

6.19e-06287214996935
Pubmed

Structural organization of the human TOP2A and TOP2B genes.

TOP2A TOP2B

6.19e-0628729795238
Pubmed

The distribution of DNA topoisomerase II isoforms in differentiated adult mouse tissues.

TOP2A TOP2B

6.19e-0628728241259
Pubmed

Mining topoisomerase isoforms in gastric cancer.

TOP2A TOP2B

6.19e-06287232535049
Pubmed

Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development.

TOP2A TOP2B

6.19e-0628721380833
Pubmed

Dynamics of human DNA topoisomerases IIalpha and IIbeta in living cells.

TOP2A TOP2B

6.19e-06287211927602
Pubmed

Topoisomerase II binds importin alpha isoforms and exportin/CRM1 but does not shuttle between the nucleus and cytoplasm in proliferating cells.

TOP2A TOP2B

6.19e-06287217182034
Pubmed

Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons.

TOP2A TOP2B

6.19e-06287228700616
Pubmed

Predictors and mechanisms of epilepsy occurrence in cerebral gliomas: What to look for in clinicopathology.

TOP2A TOP2B

6.19e-06287228087392
Pubmed

Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint.

TOP2A TOP2B

6.19e-06287228472494
Pubmed

Association of immunophenotype with expression of topoisomerase II α and β in adult acute myeloid leukemia.

TOP2A TOP2B

6.19e-06287232218491
Pubmed

Involvement of human topoisomerase II isoforms in HIV-1 reverse transcription.

TOP2A TOP2B

6.19e-06287223399433
Pubmed

Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2.

TOP2A TOP2B

6.19e-06287230169847
Pubmed

Enhanced processing of UVA-irradiated DNA by human topoisomerase II in living cells.

TOP2A TOP2B

6.19e-06287215044480
Pubmed

C-terminal regions of topoisomerase IIalpha and IIbeta determine isoform-specific functioning of the enzymes in vivo.

TOP2A TOP2B

6.19e-06287217526531
Pubmed

The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues.

TOP2A TOP2B

6.19e-0628729155056
Pubmed

DNA topoisomerase II distribution in mouse preimplantation embryos.

TOP2A TOP2B

6.19e-06287211835579
Pubmed

Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isozymes.

TOP2A TOP2B

6.19e-0628722556712
Pubmed

A study of the topoisomerase II activity in HIV-1 replication using the ferrocene derivatives as probes.

TOP2A TOP2B

6.19e-06287216712776
Pubmed

Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III.

NAALAD2 FOLH1

6.19e-06287219678840
Pubmed

Active heterodimers are formed from human DNA topoisomerase II alpha and II beta isoforms.

TOP2A TOP2B

6.19e-0628728710863
Pubmed

Distinct expression patterns for type II topoisomerases IIA and IIB in the early foetal human telencephalon.

TOP2A TOP2B

6.19e-06287226612825
Pubmed

Influence of a glutamate carboxypeptidase II (GCPII) polymorphism (1561C-->T) on plasma homocysteine, folate and vitamin B(12) levels and its relationship to cardiovascular disease risk.

NAALAD2 FOLH1

6.19e-06287212204797
Pubmed

Using a biochemical approach to identify the primary dimerization regions in human DNA topoisomerase IIalpha.

TOP2A TOP2B

6.19e-06287210473615
Pubmed

Expression and function of Dlx genes in the osteoblast lineage.

DLX1 DLX6

6.19e-06287218280462
Pubmed

Cellular distribution of mammalian DNA topoisomerase II is determined by its catalytically dispensable C-terminal domain.

TOP2A TOP2B

6.19e-0628729224616
Pubmed

DNA damage response during chromatin remodeling in elongating spermatids of mice.

TOP2A TOP2B

6.19e-06287218032420
Pubmed

Discrete localization of different DNA topoisomerases in HeLa and K562 cell nuclei and subnuclear fractions.

TOP2A TOP2B

6.19e-0628728299728
Pubmed

Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants.

TOP2A TOP2B

6.19e-06287222111588
Pubmed

Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

TOP2A TOP2B

6.19e-06287217578914
Pubmed

GCPII and its close homolog GCPIII: from a neuropeptidase to a cancer marker and beyond.

NAALAD2 FOLH1

6.19e-06287230844704
Pubmed

Single cell transcriptome analysis of developing arcuate nucleus neurons uncovers their key developmental regulators.

PIK3R1 PEG10 DLX1

1.42e-051987331420539
Pubmed

Pancreatic lipase and its related proteins: where are we now?

PNLIPRP1 PNLIPRP2

1.85e-05387238081381
Pubmed

Nuclear interactions of topoisomerase II alpha and beta with phospholipid scramblase 1.

TOP2A TOP2B

1.85e-05387217567603
Pubmed

Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis.

TOP2A TOP2B

1.85e-05387211136718
Pubmed

Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity.

NAALAD2 FOLH1

1.85e-05387210085079
Pubmed

Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2).

TOP2A TOP2B

1.85e-05387224808172
Pubmed

Ca(2+) permeable AMPA receptor induced long-term potentiation requires PI3/MAP kinases but not Ca/CaM-dependent kinase II.

PIK3R1 GRIA2

1.85e-05387219190753
Pubmed

Identification of functional nuclear export sequences in human topoisomerase IIalpha and beta.

TOP2A TOP2B

1.85e-05387212821127
Pubmed

Biochemical characterization of human glutamate carboxypeptidase III.

NAALAD2 FOLH1

1.85e-05387217241121
Pubmed

Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity.

PNLIPRP1 PNLIPRP2

1.85e-0538721379598
Pubmed

Molecular evolution of the transferrin receptor/glutamate carboxypeptidase II family.

NAALAD2 FOLH1

1.85e-05387217160644
Pubmed

Deletion of glutamate carboxypeptidase II (GCPII), but not GCPIII, provided long-term benefits in mice with traumatic brain injury.

NAALAD2 FOLH1

1.85e-05387237349952
Pubmed

Parallel Metabolomics and Lipidomics of a PSMA/GCPII Deficient Mouse Model Reveal Alteration of NAAG Levels and Brain Lipid Composition.

NAALAD2 FOLH1

1.85e-05387238377674
Pubmed

DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism.

TOP2A TOP2B

1.85e-05387223466610
Pubmed

Molecular identification of β-citrylglutamate hydrolase as glutamate carboxypeptidase 3.

NAALAD2 FOLH1

1.85e-05387221908619
Pubmed

Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53.

TOP2A TOP2B

1.85e-05387210666337
Pubmed

Nucleophagy contributes to genome stability through degradation of type II topoisomerases A and B and nucleolar components.

TOP2A TOP2B

1.85e-05387236633090
Pubmed

Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage.

TOP2A TOP2B

1.85e-05387216611985
Pubmed

Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase.

PNLIPRP1 PNLIPRP2

1.85e-0538722302735
Pubmed

Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities.

TOP2A TOP2B

1.85e-0538729049244
Pubmed

A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism.

INPP5B CLTC

1.85e-05387219536138
Pubmed

Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways.

LHX2 GRIA2 DLX1

2.58e-052387315229646
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

RPL10A WDR36 CLTC NFRKB DLX1 DLX6 TOP2A TOP2B NSMCE1 NOL8 RBM17

2.62e-05954871136373674
Pubmed

SUMO-1 conjugation to human DNA topoisomerase II isozymes.

TOP2A TOP2B

3.70e-05487210862613
Pubmed

Cloning and characterization of two members of the vertebrate Dlx gene family.

DLX1 DLX6

3.70e-0548727907794
Pubmed

A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain.

DLX1 DLX6

3.70e-05487210632600
Pubmed

Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation.

DLX1 DLX6

3.70e-0548729415433
Pubmed

Lhx9: a novel LIM-homeodomain gene expressed in the developing forebrain.

LHX2 EN2

3.70e-0548729880598
Pubmed

Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis.

TYW1B TYW1

3.70e-05487217150819
Pubmed

The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice.

PTPRZ1 PIK3R1

3.70e-05487230667096
Pubmed

Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon.

LHX2 DLX1 DLX6

3.77e-052687312397111
Pubmed

Emx2 and Pax6 function in cooperation with Otx2 and Otx1 to develop caudal forebrain primordium that includes future archipallium.

LHX2 DLX1 EN2

4.73e-052887315917450
Pubmed

Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons.

GUCY1A1 DLX1 DLX6

4.73e-052887320392955
Pubmed

The evolution of the vertebrate Dlx gene family.

DLX1 DLX6

6.16e-0558728855272
Pubmed

Neurogenin2 specifies the connectivity of thalamic neurons by controlling axon responsiveness to intermediate target cues.

LHX2 DLX1

6.16e-05587212895419
Pubmed

Ectopic expression of the Dlx genes induces glutamic acid decarboxylase and Dlx expression.

DLX1 DLX6

6.16e-05587211782417
Pubmed

Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches.

DLX1 DLX6

6.16e-0558729187081
Pubmed

Histone deacetylase interacts directly with DNA topoisomerase II.

TOP2A TOP2B

6.16e-05587211062478
Pubmed

Developmental diversification of cortical inhibitory interneurons.

LHX2 PTPRZ1 DLX1 DLX6

8.27e-059187429513653
Pubmed

Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.

TOP2A TOP2B

9.22e-05687231202577
Pubmed

Expression of Dlx genes during the development of the murine dentition.

DLX1 DLX6

9.22e-05687211180832
Pubmed

Differential expression of orthologous Dlx genes in zebrafish and mice: implications for the evolution of the Dlx homeobox gene family.

DLX1 DLX6

9.22e-05687211069141
Pubmed

A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord.

LHX2 DBX2

9.22e-05687210399918
Pubmed

Identification and characterization of a novel transcript down-regulated in Dlx1/Dlx2 and up-regulated in Pax6 mutant telencephalon.

DLX1 DLX6

9.22e-05687215376329
Pubmed

Evf2 (Dlx6as) lncRNA regulates ultraconserved enhancer methylation and the differential transcriptional control of adjacent genes.

DLX1 DLX6

9.22e-05687224089468
Pubmed

Jaw transformation with gain of symmetry after Dlx5/Dlx6 inactivation: mirror of the past?

DLX1 DLX6

9.22e-05687212434331
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

RPL10A SETDB1 WDR36 CLTC SRCAP TOP2A TOP2B

1.21e-0444087734244565
Pubmed

Homeobox gene Dlx3 is regulated by p63 during ectoderm development: relevance in the pathogenesis of ectodermal dysplasias.

DLX1 DLX6

1.29e-04787217164413
Pubmed

Comparison of the number of triplets in SCA1, MJD/SCA3, HD, SBMA, DRPLA, MD, FRAXA and FRDA genes in schizophrenic patients and a healthy population.

ATXN3 FXN

1.29e-04787211121205
Pubmed

Topoisomerase II regulates the maintenance of DNA methylation.

TOP2A TOP2B

1.29e-04787225451918
Pubmed

LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain.

LHX2 DLX1 DLX6

1.40e-044087326795843
Pubmed

Generation of regionally specified neurons in expanded glial cultures derived from the mouse and human lateral ganglionic eminence.

DLX1 DLX6

1.72e-04887211358480
Pubmed

Roles for Msx and Dlx homeoproteins in vertebrate development.

DLX1 DLX6

1.72e-04887210773441
Pubmed

A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation.

TOP2A TOP2B

1.72e-04887233188014
Pubmed

Soluble guanylate cyclase generation of cGMP regulates migration of MGE neurons.

GUCY1A1 DLX1

2.20e-04987224155296
Pubmed

Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects.

DLX1 DLX6

2.20e-04987218326838
GeneFamilyNKL subclass homeoboxes and pseudogenes

DBX2 DLX1 DLX6 EN2

6.29e-0567584519
GeneFamilyTopoisomerases

TOP2A TOP2B

1.50e-0465821050
GeneFamilyLipases|Arylacetamide deacetylase family

PNLIPRP2 LIPI

2.24e-0322582464
ToppCellNS-moderate-d_07-13-Epithelial-FOXN4+|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

LHX2 NAALAD2 WDR5B LRRIQ1 PCSK4 PLK4 CFAP46

2.55e-08157877410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCell10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

VWA3A LRRIQ1 SYNE2 SLITRK6 CCDC141 CFAP46

6.32e-0715687610d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VWA3A LRRIQ1 DPY19L2 SLITRK6 WDR17 CFAP46

1.01e-06169876fba841664939c771881ba97f14ef1df6635c04ff
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

FRY GUCY1A1 PEG10 GRIA2 DLX6 SLITRK6

1.99e-061908766e92c78799f34b31d098854503c796edb0dc7f80
ToppCellfacs-Heart-Unknown-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPA4 ABCA4 MX2 KCNH5 TDRD12

8.46e-061418754aa4b3476dc5abefbd348353cfe711cd5fe3d52f
ToppCellfacs-Heart-Unknown-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPA4 ABCA4 MX2 KCNH5 TDRD12

8.46e-06141875e40c6f1b7fbaa46b3eaa55f1b37ef360b04370a8
ToppCellfacs-Heart-Unknown-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPA4 ABCA4 MX2 KCNH5 TDRD12

8.76e-06142875759fbbd15b4fb313bd6269b7f087edafebd530ef
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O1-Tfr|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

BTBD16 FOLH1 FAM151A EN2

1.08e-0570874b159435487b90331d2d276f182fc8aedf88d612c
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O1-Tfr-Oligodendrocyte.Tfr.Il33_(Il33)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

BTBD16 FOLH1 FAM151A EN2

1.08e-05708747e09547b73789d789c3c464689f7998445830238
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O1|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

BTBD16 FOLH1 FAM151A EN2

1.08e-0570874b486f7fe68743e3385809cfd64512da2f31074df
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O1-Tfr-Oligodendrocyte.Tfr.Il33_(Il33)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

BTBD16 FOLH1 FAM151A EN2

1.08e-05708748ee9c9c78eec9dc0cec364ee7c9bc6f34d37de76
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial-endothelial_cells_B|E18.5-samps / Age Group, Lineage, Cell class and subclass

PNLIPRP1 PCDHGA9 DLX6 NOSTRIN MX2

1.71e-05163875d6f9b7280c44d120df5a72dfc2ebb26ffbb5752b
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Differentiating_glia|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CLEC4F PTPRZ1 DLX1 DLX6 SLITRK6

1.76e-0516487557301178e420983c0cb72178e288a3a0449fdda3
ToppCellE16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWA3A LRRIQ1 DPY19L2 DMKN CFAP46

1.97e-05168875fa7c0303918cea04e3f4c4f3cb079be19004d214
ToppCellE16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWA3A LRRIQ1 DPY19L2 DMKN CFAP46

1.97e-051688757edcab103c69e928d5c19a0d218ffb3ae32f9e70
ToppCellCOVID-19-Heart-Neuronal|Heart / Disease (COVID-19 only), tissue and cell type

GPR155 PTPRZ1 ASTN2 DLX1 SLITRK6

2.27e-051738756fb5f9e6536a5d57fd8e6657b494047a2d0bc9c7
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_TMEM233|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VWA3A LHX2 LRRIQ1 PEG10 DNAH14

2.67e-05179875747a32460b257fffca30527b56a74720eb9c12e4
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRRIQ1 PCSK4 PLK4 TOP2A CFAP46

2.75e-051808750c146e80d55d18b6988dd21b1da635801bd3140c
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRRIQ1 PCSK4 PLK4 TOP2A CFAP46

2.75e-05180875e9af22beae2f3c7fe213b4e19df84abfd2453433
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRRIQ1 PCSK4 PLK4 TOP2A CFAP46

2.75e-0518087511455ba704ac73f69b474845136cfecec6a88349
ToppCellRA-16._Neuronal|World / Chamber and Cluster_Paper

GPR155 PTPRZ1 ASTN2 DLX1 SLITRK6

2.82e-051818757d22a43f887e0747f0cb87ba364ff27905ee6eec
ToppCellcellseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LRRIQ1 DPY19L2 PLK4 TOP2A CFAP46

2.90e-05182875deb53a4f84e4cd5c3b4180a4ac43249da9d738f7
ToppCell15-Trachea-Epithelial-Multiciliated_precursor|Trachea / Age, Tissue, Lineage and Cell class

LRRIQ1 DPY19L2 PLK4 TOP2A CFAP46

3.13e-051858759a8b8360d99375b726ca8e3c9a3f9b08919892d7
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 ACTR3C SYNE2 ASTN2 DNAH14

3.21e-05186875f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 ACTR3C SYNE2 ASTN2 DNAH14

3.30e-05187875c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 ACTR3C SYNE2 ASTN2 DNAH14

3.38e-05188875af740fa78542438fdff627ea1f74f4eee43316be
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

NDC1 WDR36 FRYL TYW1 LYST

3.65e-051918759454f642c3621370fa23640b631301346b300950
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GUCY1A1 DMKN PIK3R1 PEG10 GRIA2

3.83e-051938757cd9671e0ac64f7f3607f564485c63abbb7e7a63
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

VWA3A LRRIQ1 DPY19L2 PLK4 TOP2A

4.02e-05195875e525b69145059b66417589601f7109af63730f3a
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

VWA3A LRRIQ1 SYNE2 TOP2A CFAP46

4.12e-05196875af4cdc61830685a888a1209826c23bcf54a43084
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LHX2 PTPRZ1 OVOS2 GRIA2 TOP2A

4.12e-051968758faac7fbdee3a9297023c3151ef1751605413e44
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

VWA3A LRRIQ1 SYNE2 TOP2A CFAP46

4.12e-051968756d02d494196e3f857d53eea46d9419690d43beca
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VWA3A LRRIQ1 DPY19L2 SYNE2 CFAP46

4.22e-0519787574a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_ciliated-Deuterosomal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

VWA3A LRRIQ1 PLK4 TOP2A CFAP46

4.33e-05198875f31790442ef142f1c0c49bf3daf2d0efb193d2c9
ToppCellMS-IIF-Lymphocyte-T/NK-Treg|IIF / Disease, condition lineage and cell class

RPL10A PIK3R1 SYNE2 UGP2 CCDC141

4.33e-051988757bbf8403ecf9f8e403b04f18d265ece977cc49e7
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-immature_mesenchymal_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GUCY1A1 PEG10 SYNE2 SLITRK6 TOP2A

4.43e-0519987501ab0363558f215f9979e20fd5170d8fee149cea
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-BMP_responsible_cell|6m / Sample Type, Dataset, Time_group, and Cell type.

VWA3A ABCA4 LRRIQ1 DMKN SYNE2

4.54e-052008755fb90118d3abc28d72bc483e68317255090a04c7
ToppCellFrontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Slc24a2_(Deep_layer_pyramidal_cells)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CPA4 DPY19L2 TDRD12

8.73e-0544873405ac4aeee539322cfe661c7531248f81271be8d
ToppCellFrontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Slc24a2_(Deep_layer_pyramidal_cells)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CPA4 DPY19L2 TDRD12

8.73e-0544873a2c99e8ca635590a1f167b68bc390e2aa01e26be
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Thalamus / BrainAtlas - Mouse McCarroll V32

PCDHGA9 DGKK DLX1 DLX6

2.02e-04148874afebb64365c94b9476494bffe7c364677f19c8cf
ToppCellThalamus-Neuronal-Inhibitory|Thalamus / BrainAtlas - Mouse McCarroll V32

PCDHGA9 DGKK DLX1 DLX6

2.02e-041488745f82e5ecacfd223020b8ee975c17d68c1fe6db38
ToppCellCiliated_cells-B-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

LRRIQ1 DPY19L2 SLITRK6 CFAP46

2.08e-041498746399c5a2f06d79f020dece252526f1c0c110d569
ToppCellCOVID-19-Epithelial_cells-Airway_mucous|COVID-19 / group, cell type (main and fine annotations)

VWA3A LRRIQ1 EN2 CFAP46

2.19e-041518748216462e723fec2797387929dde095370947e10a
ToppCellprimary_visual_cortex-Non-neuronal-astrocyte|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DBX2 FOLH1 PTPRZ1 CCDC141

2.30e-0415387495b28c5bd10ffb74c0993ebd565038b9818e4bd2
ToppCellprimary_visual_cortex-Non-neuronal-astrocyte-Astro|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DBX2 FOLH1 PTPRZ1 CCDC141

2.30e-04153874b09f8def40a1ea56722f3398f61a036667b61cd9
ToppCellprimary_visual_cortex-Non-neuronal-astrocyte-Astro-Astro_Aqp4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DBX2 FOLH1 PTPRZ1 CCDC141

2.30e-041538743ab9d55b3db51715c1d61eca142384195ce4b54f
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CHST10 FRY DPY19L2 SRCAP

2.36e-04154874ba55a63cfa5e0fb9dfec794f80078a2f0d03d0ad
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_TNFAIP8L3|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

OVOS2 NOSTRIN SLITRK6 CCDC141

2.92e-041638747352c30c253f69f65dcb15f46f9c87719741b55b
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

REP15 PTPRZ1 DLX1 WDR17

2.92e-0416387499cf60dc87f7ce288553091bffcd85109a02bd8f
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

REP15 PTPRZ1 DLX1 WDR17

2.92e-04163874510c0af66e82c5a8cf8edd0547dae4018a87dbbf
ToppCellfacs-Trachea-nan-18m-Epithelial-mucus_secreting_cell|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPA4 BTBD16 GIP DLX1

3.06e-041658747e7643834ed483aec04f513cca38d6367fda9ff8
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_6|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GPR155 SYNE2 UGP2 CCDC141

3.06e-04165874dbe231d00843cae917efd1abea6079ace3b45cdf
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_6|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GPR155 SYNE2 UGP2 CCDC141

3.06e-041658749ccce713d4122054bf4bef4a7126d90cf9141b84
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|356C / Donor, Lineage, Cell class and subclass (all cells)

CHST10 TYW1B SYNE2 CCDC141

3.13e-04166874c4f7ea1cad962b1d6ad77423d15978b68a0d6f1d
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE-O1-Trf|Hippocampus / BrainAtlas - Mouse McCarroll V32

BTBD16 FOLH1 EN2

3.20e-046887331f9f6b4473970473f89b67643bb55dc332732d8
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Il33_(Il33)|Hippocampus / BrainAtlas - Mouse McCarroll V32

BTBD16 FOLH1 EN2

3.20e-046887391a500a68245a8a484a537aad2cc8b62ff4579f0
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Il33_(Il33)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

BTBD16 FOLH1 EN2

3.20e-0468873a89cc6fb62f50ea4124b1a6b0b30cd7ceb52e408
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE-O1|Hippocampus / BrainAtlas - Mouse McCarroll V32

BTBD16 FOLH1 EN2

3.20e-04688733d148bb49246c3fac9a1e864ecc5e15b29863c52
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Epithelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPA4 LHX2 DMKN SLITRK6

3.21e-0416787469caf4a53805f8c104d7dd8f88665fc992e23720
ToppCellLA-16._Neuronal|World / Chamber and Cluster_Paper

GPR155 PTPRZ1 DLX1 SLITRK6

3.28e-041688742fd1fd2a16ac1c5eb028f93cc3a2477c7747693e
ToppCellLA-16._Neuronal|LA / Chamber and Cluster_Paper

GPR155 PTPRZ1 DLX1 SLITRK6

3.28e-04168874c55bbfbde8bb954f1cb9af82007bdd1f8070fee3
ToppCellLV-16._Neuronal|LV / Chamber and Cluster_Paper

GPR155 PTPRZ1 ASTN2 SLITRK6

3.35e-04169874a8fc8ab0f0757e939e213efb61c03cfe390bf7d2
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VWA3A LRRIQ1 PCSK4 CFAP46

3.35e-0416987414aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCellPND01-03-samps-Mesenchymal-Pericyte-pericyte_F|PND01-03-samps / Age Group, Lineage, Cell class and subclass

CPA4 NAALAD2 WDR5B GUCY1A1

3.43e-0417087471718dcebd48105994c313bb55babc70301170a0
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NAALAD2 GUCY1A1 NOSTRIN SLITRK6

3.43e-041708741f994b690e881106a5d54b3080ccce6260bc3ac5
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating-cycling_ventral_progenitors|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

OVOS2 DLX1 DLX6 TOP2A

3.43e-0417087473601c873b177d5d134618d8e228c51381119f7d
ToppCellCiliated_cells-A-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

VWA3A LRRIQ1 FOLH1 TCTN2

3.43e-041708743d3a03979014df3a05c49be18010c6b94d786707
ToppCell5'-Adult-SmallIntestine-Hematopoietic-T_cells-CX3CR1+_CD8_Tmem|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PIK3R1 DGKK LYST NOL8

3.51e-04171874187b396059f8802265f54bad2b4882cebb809419
ToppCellwk_20-22-Epithelial-Proximal_epithelial-Deuterosomal|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

BTBD16 LRRIQ1 PLK4 CFAP46

3.51e-0417187452aec5f6677fe2f7a36fb5b18117a4cffaeff58f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PEG10 OVOS2 DLX1 DLX6

3.66e-041738740ba64e5385fe714f876002520f8b5202809bf11e
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-5_VIP_KCNJ2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PEG10 OVOS2 DLX1 DLX6

3.75e-04174874fdadac1eaab2c4a67e4832f0901df22e893add6a
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NAALAD2 GUCY1A1 PLK4 TOP2A

3.83e-0417587415c69dd5635c9251c535f1e22467712e9667ae92
ToppCellCV-Severe-7|CV / Virus stimulation, Condition and Cluster

WDR36 DPY19L2 SCAF8 LYST

3.91e-041768743de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell-ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRRIQ1 DMKN SLITRK6 CFAP46

4.00e-041778743cfde67b93f3986312f5e74e42504214d966e7dc
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRRIQ1 DMKN SLITRK6 CFAP46

4.00e-0417787412a52a12a87a31e501ced611f46a90d172ca7e35
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-9|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ACTR3C PEG10 ANKAR TCTN2

4.00e-04177874ae55773c531099a9e94f44f01ba48b5e71dddc53
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE2 UBXN2A LYST MX2

4.08e-0417887401dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell(5)_Glands_mucous|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

GUCY1A1 PEG10 GRIA2 SLITRK6

4.08e-04178874f0f19b0d78f2cc5df4d4c321a953a6e447d5114a
ToppCellfacs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRY GUCY1A1 INPP5B TDRD12

4.17e-041798748da6863edc756540bb097cc7221c1408640d9bb4
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ABCA4 GUCY1A1 PEG10 CCDC141

4.17e-0417987440c65e8623547aeb80f9cd2366e29072467ce069
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c11-MKI67-FOS|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

NDC1 LIPI PLK4 TOP2A

4.17e-04179874ac987c9425a1b4106d1b8779a2c5461383eae2ae
ToppCellfacs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRY GUCY1A1 INPP5B TDRD12

4.17e-04179874f39c13c99a07d009cc677e363ffe089089c64916
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VWA3A LRRIQ1 GRIA2 CFAP46

4.17e-041798745e5f1cdf4aa66868d45b74ba91e20e848a3cbaff
ToppCell(5)_Epithelial_cells-(5)_Glands_mucous|(5)_Epithelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

GUCY1A1 PEG10 GRIA2 NOSTRIN

4.26e-04180874a4118adaf4b09e2ca01b662ed60e7bbf32a24d58
ToppCelldroplet-Heart-nan-3m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRZ1 DLX1 SLITRK6 PLK4

4.26e-04180874da723df348d7b8449bb1124f23fe6fa706412adb
ToppCellRA-16._Neuronal|RA / Chamber and Cluster_Paper

GPR155 PTPRZ1 DLX1 SLITRK6

4.26e-041808745842febfdabac61ce970254fb0ef17a628f1b8c0
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRZ1 GRIA2 NOSTRIN SLITRK6

4.26e-041808748bf6e8b6b45ce42f8c5f23e7cd1752ec8b3fa2d2
ToppCelldroplet-Heart-nan-3m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRZ1 DLX1 SLITRK6 PLK4

4.26e-041808745b146a94708b3c3610542a4d0925f3f7a2b19185
ToppCelldroplet-Heart-nan-3m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRZ1 DLX1 SLITRK6 PLK4

4.26e-0418087450758b1e7be2e43f83c10ab106900c067e61f5f7
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Deuterosomal|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

BTBD16 LRRIQ1 PLK4 CFAP46

4.44e-04182874000eca5baa6eb2335a1e6d76a13fff5382b0e150
ToppCellCiliated_cells-B-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

VWA3A LRRIQ1 SLITRK6 CFAP46

4.44e-04182874e44c4810dc7d51a76b86d7623f8e4c4d8b4bf2fc
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LHX2 LRRIQ1 CFAP46 KCNH5

4.44e-0418287414a117c5e50db31ee1b2cf4df4d133451fd6d55f
ToppCell21-Trachea-Epithelial-Multiciliated_precursor|Trachea / Age, Tissue, Lineage and Cell class

LRRIQ1 DPY19L2 PLK4 CFAP46

4.44e-041828746e35892fa959ee31591850ded8f1088195ddeb01
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-large_intestine_goblet_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

REP15 PEG10 ANKAR EN2

4.53e-041838745a936fb07074cec753bf19e3e3e52499605ea22c
ToppCell18-Airway-Epithelial-Multiciliated_precursor|Airway / Age, Tissue, Lineage and Cell class

LRRIQ1 DPY19L2 PLK4 CFAP46

4.53e-04183874a75cda2131755931117c387f2e0ae3394efa8e80
ToppCellE12.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

GUCY1A1 NOSTRIN PPID PLK4

4.53e-04183874523896bd1a93bdda81a009768baa3a1bdbd108b8
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Goblet_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

REP15 PEG10 ANKAR EN2

4.53e-0418387407c18ccc45ddc9c22e482bd9ffb87f46ebcfe473
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS15 ABCA4 FOLH1 DGKK

4.62e-041848742cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS15 ABCA4 FOLH1 DGKK

4.62e-04184874ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS15 ABCA4 FOLH1 DGKK

4.62e-041848742b19a8c5f823e00812908b23e66bb4e563278aff
DrugAC1NUUB8

GCFC2 PCSK4 PPID LYST

5.52e-0631864CID005493639
DrugThr-Gln

GIP TMPRSS15

1.41e-052862CID003618482
DrugDexrazoxane

TOP2A TOP2B

1.41e-052862DB00380
DrugF14512

TOP2A TOP2B

1.41e-052862ctd:C534191
DrugDaunorubicin

TOP2A TOP2B

1.41e-052862DB00694
DiseaseB cell deficiency (implicated_via_orthology)

TOP2A TOP2B

8.20e-062852DOID:2115 (implicated_via_orthology)
Diseaseacute myeloid leukemia (implicated_via_orthology)

TOP2A TOP2B

5.31e-0412852DOID:9119 (implicated_via_orthology)
Diseaselevel of Sphingomyelin (d32:1) in blood serum

SYNE2 KCNH5

1.08e-0317852OBA_2045173
Diseaseprostate cancer (is_marker_for)

SETDB1 PNLIPRP1 PIK3R1 TOP2A

1.09e-03156854DOID:10283 (is_marker_for)
Diseasecaudal middle frontal gyrus volume measurement

FRY ASTN2

1.22e-0318852EFO_0010290
Diseaseamygdala volume change measurement, age at assessment

LHX2 FOLH1

2.55e-0326852EFO_0008007, EFO_0021490

Protein segments in the cluster

PeptideGeneStartEntry
VSPNITQLFQKQKWT

ABCA4

1466

P78363
KWQEFRTNQIKQKFG

BTBD16

461

Q32M84
QFKTLWNGQKLVTTV

CAP1

456

Q01518
ATWVKAKQLLQQQIG

CFAP46

861

Q8IYW2
QDFVNWLLAQKGKKN

GIP

71

P09681
GLTQTQVKIWFQNKR

DLX1

166

P56177
LGLTQTQVKIWFQNK

DLX6

86

P56179
PSKKVQQQLWLQYQK

ASTN2

921

O75129
VALWALAGQTLKQQK

ANKAR

971

Q7Z5J8
GLNQIWNVKKQSVYL

FXN

61

Q16595
GTYVINKQTPNKQIW

FXN

141

Q16595
GIKYNEKWLLNLIQN

NXF3

121

Q9H4D5
IVKAWGQIKQNNTAI

DGKK

686

Q5KSL6
FKEKTQQWKLLGQSQ

NFRKB

451

Q6P4R8
IWNFVKEKNFVGQIL

GPR155

431

Q7Z3F1
QKWIKQYTGINAINQ

ACTR3C

121

Q9C0K3
FTVRKLGKQWFNLNS

ATXN3

121

P54252
FCVWILNAQKGKNIQ

TMPRSS15

551

P98073
QLAKQIQSQWKEFGL

FOLH1

91

Q04609
VSFKTKQNNIAWLVL

KCNH5

236

Q8NCM2
KKWQVTAINVGNINN

GRIA2

171

P42262
LHLKKNPKVQWFQQQ

PCSK4

91

Q6UW60
GTIEKVKFLWNNNVI

PNLIPRP1

411

P54315
VKNKQIQWGMLNFLS

OR51Q1

296

Q8NH59
FWKINEKQSLLFQLN

PCDHGA9

281

Q9Y5G4
NVQSKLKWTNFPGLQ

FRYL

2046

O94915
QVLQVKRGWKLQVSY

PEG10

581

Q86TG7
QKTGLTKRVLQVWFQ

LHX2

301

P50458
VLNKTKWKGGTLQIQ

NOL8

71

Q76FK4
TQVNVNLKKLKFQGW

PTPRZ1

71

P23471
NVQKQTLIWLSSQQK

OVOS2

1046

Q6IE36
QKGVRQKKLNEWLGN

PIK3R1

586

P27986
QKLGVSKLNFWLIQG

DPY19L2

416

Q6NUT2
PWLEIFKQNQQKKIV

LRRIQ1

751

Q96JM4
KQWIQGGKQETQLLE

MAN1B1

471

Q9UKM7
KYLKQQWQELSQVLQ

CCDC141

236

Q6ZP82
SKLGFINWDAINKNQ

DMKN

366

Q6E0U4
NIQNILLKFQQWREK

GCFC2

466

P16383
INLGLKESQVKIWFQ

DBX2

221

Q6ZNG2
QLSKNQVKWVFAGIT

FAM151A

6

Q8WW52
SQLVNSNNLKLNFWK

CPA4

41

Q9UI42
NSEIINWKQKLQIQG

GLYATL1B

91

A0A0U1RQE8
NWKQKLQIQGFQESL

GLYATL1B

96

A0A0U1RQE8
QQLGLQNWSSQKEKI

DNAH14

1396

Q0VDD8
CNLIQKGNIVVQWKL

LYST

716

Q99698
ILWKGKNITQLSYQS

INPP5B

606

P32019
QLLTQWKLVIQTQGK

FRY

691

Q5TBA9
LSLNESQIKIWFQNK

EN2

281

P19622
VRVLNLWQKNNVFKS

SCAF8

111

Q9UPN6
LQQVFQLIQKVLSKW

IPO13

681

O94829
SQNWRALKQQLVNKF

CNTD1

106

Q8N815
AEQVLQKFVQNKWLI

NSMCE1

146

Q8WV22
QKVKFLWNKRGINLS

PNLIPRP2

416

P54317
GKKINNIWGAVLQEQ

PHAX

111

Q9H814
KTANLVISNWNQQIK

NOSTRIN

121

Q8IVI9
VGLQQWIQKLSKNTV

SLITRK6

526

Q9H5Y7
SILNWVKFKAQTQLN

TOP2B

431

Q02880
QLQKAQSLLQLWKAY

SYNE2

5376

Q8WXH0
LNVNFNTQKKTVWLI

LIPI

66

Q6XZB0
FNLQNVLEQWKKKLS

TDRD12

711

Q587J7
WTINGKFQQSGQKLF

PSG9

366

Q00887
LKNIGNTFFKSQNWE

PPID

226

Q08752
QLRWINLNKNKITNY

KERA

96

O60938
AFIWNVQKGKIIQRF

WDR17

461

Q8IZU2
IKNFKSQRWQSLLNF

SRCAP

751

Q6ZRS2
QLLKSVFVKNVGWAT

PLK4

886

O00444
LQVRLQLFKTQNKGW

SETDB1

801

Q15047
KQKWLLLTGISAQQN

CLTC

161

Q00610
NTQWKKVLIVLNGAF

CHST10

131

O43529
TQSQLLQMVLQGWKF

CLEC4F

461

Q8N1N0
VSKFKIFNTNNLWIS

UGP2

321

Q16851
IWNLQTKEIVQKLQG

WDR5B

281

Q86VZ2
TEGWSKNFKLLQSQL

RBM17

16

Q96I25
SLSKLLVVWNNQNKN

EXT2

481

Q93063
VDVNIKLWKNGFTVN

UBXN2A

61

P68543
TFWGSNKQIKLQLAV

REP15

96

Q6BDI9
AVNFLVSLLKKNWQN

RPL10A

186

P62906
ILNWVKFKAQVQLNK

TOP2A

411

P11388
AWKTKFISQLQALQK

TYW1

231

Q9NV66
IFKWNNNTISEINVK

TCTN2

386

Q96GX1
QFVNGRWIKSQKIVK

USP32

1286

Q8NFA0
WKTKFISQLQALQKG

TYW1B

186

Q6NUM6
LWQAQSFRSQLQKKN

VWA3A

1161

A6NCI4
QGSLQLWNVKSNKLL

WDR36

226

Q8NI36
FQPSVQKQLKNVKWV

ZNF518B

421

Q9C0D4
LWQGQVVQAKKFSNV

GUCY1A1

466

Q02108
WVGILATNTQKVKNI

MX2

461

P20592
TEQNFLLAKKIQTQW

NAALAD2

76

Q9Y3Q0
WIQNKREQIKNFLSK

NDC1

521

Q9BTX1