Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	nuclear body	ZNF106 SBF1 CCNB3 USH1G OBSCN SAFB2 DAXX BCL11A CMYA5 ARHGAP18 WRAP53 SRCAP NME8 TP53BP1	1.35e-05	903	84	14	GO:0016604
Domain	VCX/VCY1	VCX2 VCX3A VCX3B VCX	1.81e-09	5	83	4	IPR026653
Domain	VCX_VCY	VCX2 VCX3A VCX3B VCX	1.81e-09	5	83	4	PF15231
Domain	LRRC37AB_C	LRRC37A LRRC37A3 LRRC37A2	3.37e-07	4	83	3	PF14914
Domain	LRRC37_N	LRRC37A LRRC37A3 LRRC37A2	3.37e-07	4	83	3	IPR032754
Domain	LRRC37AB_C	LRRC37A LRRC37A3 LRRC37A2	3.37e-07	4	83	3	IPR029423
Domain	LRRC37	LRRC37A LRRC37A3 LRRC37A2	3.37e-07	4	83	3	PF15779
Domain	LRRC37A/B-like	LRRC37A LRRC37A3 LRRC37A2	3.37e-07	4	83	3	IPR015753
Domain	FN3_dom	TSPOAP1 OBSCN CMYA5 CNTN2 IL6ST IFNAR2	3.37e-04	209	83	6	IPR003961
Domain	fn3	TSPOAP1 OBSCN CMYA5 CNTN2 IL6ST	7.77e-04	162	83	5	PF00041
Domain	SET	SETDB1 SETD2 PRDM2	7.99e-04	41	83	3	PF00856
Domain	SET	SETDB1 SETD2 PRDM2	1.12e-03	46	83	3	SM00317
Domain	CRAL_TRIO_2	PRUNE2 NF1	1.25e-03	12	83	2	PF13716
Domain	FN3	TSPOAP1 OBSCN CMYA5 CNTN2 IL6ST	1.40e-03	185	83	5	SM00060
Domain	SET_dom	SETDB1 SETD2 PRDM2	1.43e-03	50	83	3	IPR001214
Domain	SET	SETDB1 SETD2 PRDM2	1.43e-03	50	83	3	PS50280
Domain	FN3	TSPOAP1 OBSCN CMYA5 CNTN2 IL6ST	1.94e-03	199	83	5	PS50853
Domain	GRAM	SBF1 GRAMD1C	2.25e-03	16	83	2	SM00568
Domain	Post-SET_dom	SETDB1 SETD2	2.25e-03	16	83	2	IPR003616
Domain	PostSET	SETDB1 SETD2	2.25e-03	16	83	2	SM00508
Domain	POST_SET	SETDB1 SETD2	2.25e-03	16	83	2	PS50868
Domain	GRAM	SBF1 GRAMD1C	4.25e-03	22	83	2	PF02893
Domain	GRAM	SBF1 GRAMD1C	4.25e-03	22	83	2	IPR004182
Domain	SEC14	PRUNE2 NF1	5.48e-03	25	83	2	SM00516
Domain	HECT	UBR5 UBE3A	6.37e-03	27	83	2	PF00632
Domain	HECTc	UBR5 UBE3A	6.37e-03	27	83	2	SM00119
Domain	HECT_dom	UBR5 UBE3A	6.37e-03	27	83	2	IPR000569
Domain	CRAL_TRIO	PRUNE2 NF1	6.37e-03	27	83	2	PS50191
Domain	HECT	UBR5 UBE3A	6.37e-03	27	83	2	PS50237
Domain	AT_hook	PDS5B SRCAP	6.37e-03	27	83	2	SM00384
Domain	AT_hook_DNA-bd_motif	PDS5B SRCAP	6.37e-03	27	83	2	IPR017956
Domain	CRAL-TRIO_dom	PRUNE2 NF1	6.84e-03	28	83	2	IPR001251
Domain	Rho_GTPase_activation_prot	NF1 ARHGAP27 ARHGAP18	7.08e-03	88	83	3	IPR008936
Domain	LRR_8	LRRC37A LRRC37A3 LRRTM4 LRRC37A2	7.11e-03	171	83	4	PF13855
Domain	Leu-rich_rpt_typical-subtyp	LRRC37A LRRC37A3 LRRTM4 LRRC37A2	8.01e-03	177	83	4	IPR003591
Domain	LRR_TYP	LRRC37A LRRC37A3 LRRTM4 LRRC37A2	8.01e-03	177	83	4	SM00369
Pubmed	A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation.	VCX2 VCX3A VCX3B VCX	3.32e-11	4	85	4	10903929
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PDS5B ZNF106 SETD2 ERCC5 NF1 SAFB2 TJP2 POU2F1 DAXX DBN1 WRAP53 INTS3 ZMYM3 TP53BP1 PRDM2	6.04e-10	774	85	15	15302935
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PDS5B SETDB1 INTU SLK KIDINS220 UBR5 TSPOAP1 BCL11A FHIP2A SNX19 ZMYM3	4.84e-09	407	85	11	12693553
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SETDB1 SETD2 NF1 POLR1A SBF1 UBR5 AIFM1 LMTK2 DAXX SRCAP TP53BP1	1.08e-08	440	85	11	34244565
Pubmed	Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis.	VCX2 VCX3A VCX3B	1.41e-08	3	85	3	18076704
Pubmed	Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.	LRRC37A LRRC37A3 LRRC37A2	5.63e-08	4	85	3	22419166
Pubmed	A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins.	VCX2 VCX3A VCX	1.40e-07	5	85	3	10607842
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	SETDB1 SETD2 MIS18BP1 UBR5 BACH2 BCORL1 DAXX BSN SRCAP ZMYM3 TP53BP1	2.03e-07	588	85	11	38580884
Pubmed	Evolutionary dynamism of the primate LRRC37 gene family.	LRRC37A LRRC37A3 LRRC37A2	1.67e-06	10	85	3	23064749
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DMXL2 SLK NF1 SBF1 UBR5 UBE3A PURA SAFB2 BCL11A DBN1 BSN TP53BP1	3.90e-06	963	85	12	28671696
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	PDS5B POLR1A PURA DAXX DBN1 SRCAP ZMYM3 TP53BP1	5.69e-06	394	85	8	27248496
Pubmed	Modulation of neuritogenesis by a protein implicated in X-linked mental retardation.	VCX3A VCX3B	5.90e-06	2	85	2	19812318
Pubmed	Regulation of the human papillomavirus type 18 E6/E6AP ubiquitin ligase complex by the HECT domain-containing protein EDD.	UBR5 UBE3A	5.90e-06	2	85	2	21228227
Pubmed	Identification of SETD2-NF1 fusion gene in a pediatric spindle cell tumor with the chromosomal translocation t(3;17)(p21;q12).	SETD2 NF1	5.90e-06	2	85	2	28498454
Pubmed	Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas.	PRUNE2 OBSCN	5.90e-06	2	85	2	17360660
Pubmed	A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene.	NF1 BCL11A	5.90e-06	2	85	2	18948576
Pubmed	Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis.	VCX3B VCX	5.90e-06	2	85	2	12862317
Pubmed	Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.	POLR1A CWC27 AIFM1 PURA DBN1 INTS3	1.68e-05	219	85	6	31353912
Pubmed	Repurposing the CRISPR-Cas9 system for targeted DNA methylation.	BACH2 IL6ST	1.77e-05	3	85	2	26969735
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	SETDB1 SAFB2 DAXX SRCAP INTS3 ZMYM3 TP53BP1	1.77e-05	332	85	7	32786267
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	PDS5B MIS18BP1 CWC27 BCORL1 POU2F1 DAXX SRCAP ZMYM3 PRDM2	1.82e-05	608	85	9	36089195
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	PDS5B MIS18BP1 NF1 POLR1A SBF1 UBR5 UBE3A AIFM1 HIP1R SAFB2 SRCAP ZMYM3 TP53BP1	2.41e-05	1353	85	13	29467282
Pubmed	The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery.	INTU CPLANE1	3.53e-05	4	85	2	27158779
Pubmed	Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes.	TSPOAP1 UBE3A	3.53e-05	4	85	2	19557195
Pubmed	Expression of the histone lysine methyltransferases SETD1B, SETDB1, SETD2, and CFP1 exhibits significant changes in the oocytes and granulosa cells of aged mouse ovaries.	SETDB1 SETD2	3.53e-05	4	85	2	35445296
Pubmed	Replication stress induces 53BP1-containing OPT domains in G1 cells.	POU2F1 TP53BP1	3.53e-05	4	85	2	21444690
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	SETDB1 UBR5 AIFM1 TJP2 TP53BP1	3.81e-05	153	85	5	26365490
Pubmed	Human transcription factor protein interaction networks.	SETDB1 SLK AIFM1 PEG10 PURA BCORL1 POU2F1 BCL11A DBN1 SRCAP ZMYM3 TP53BP1 PRDM2	4.24e-05	1429	85	13	35140242
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	PDS5B ZNF106 SETDB1 DMXL2 MIS18BP1 NF1 BACH2 OSBPL9 DBN1 ARHGAP18 WRAP53 TIMMDC1	4.85e-05	1242	85	12	30973865
Pubmed	IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3.	IL6ST IFNAR2	5.87e-05	5	85	2	21148800
Pubmed	ATF-2 controls transcription of Maspin and GADD45 alpha genes independently from p53 to suppress mammary tumors.	NF1 POU2F1	5.87e-05	5	85	2	17700520
Pubmed	TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes.	UBR5 TP53BP1	5.87e-05	5	85	2	22884692
Pubmed	ATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichment.	SETDB1 DAXX	5.87e-05	5	85	2	27029610
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SETDB1 SETD2 INTU IGFBP1 UBR5 CCNB3 BACH2 BCL11A RAB11FIP1 SRCAP ZMYM3	8.61e-05	1116	85	11	31753913
Pubmed	Differential effects of HTLV-1 Tax oncoprotein on the different estrogen-induced-ER α-mediated transcriptional activities.	CNTN2 TP53BP1	8.80e-05	6	85	2	27420286
Pubmed	The proximity ligation assay reveals that at DNA double-strand breaks WRAP53β associates with γH2AX and controls interactions between RNF8 and MDC1.	WRAP53 TP53BP1	8.80e-05	6	85	2	26734725
Pubmed	A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family.	VCX3B VCX	8.80e-05	6	85	2	17342728
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	DMXL2 NF1 TSPOAP1 UBE3A PURA HIP1R LMTK2 TJP2 DBN1 BSN TP53BP1	1.03e-04	1139	85	11	36417873
Pubmed	A germline-specific class of small RNAs binds mammalian Piwi proteins.	SBF1 LRRC37A2 HIP1R POU2F1 BSN TIMMDC1 SNX19	1.20e-04	450	85	7	16751776
Pubmed	Placentation defects are highly prevalent in embryonic lethal mouse mutants.	DMXL2 DBN1 WRAP53 TIMMDC1	1.22e-04	103	85	4	29539633
Pubmed	WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.	ZNF106 DMXL2 WRAP53	1.30e-04	40	85	3	29078390
Pubmed	Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.	UBR5 PURA OSBPL9 DBN1 TIMMDC1 TP53BP1	1.68e-04	332	85	6	29053956
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	PDS5B SLK KIDINS220 NF1 POLR1A AIFM1 RGS22 SAFB2 DBN1 CMYA5 BSN PRDM2	1.77e-04	1425	85	12	30948266
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DMXL2 SLK KIDINS220 NF1 SBF1 PURA OSBPL9 TJP2 BCL11A DBN1 BSN CNTN2	1.84e-04	1431	85	12	37142655
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	PDS5B UBE3A PEG10 SAFB2 SRCAP TP53BP1	1.94e-04	341	85	6	32971831
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	SLK AIFM1 PURA SAFB2 DAXX BSN WRAP53 PUS7	2.00e-04	653	85	8	33742100
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	PDS5B NF1 POLR1A SBF1 UBR5 TJP2 ZMYM3 TP53BP1	2.00e-04	653	85	8	22586326
Pubmed	Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX.	SETDB1 DAXX	2.10e-04	9	85	2	29084956
Pubmed	The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.	ERCC5 SBF1 OSBPL9 TJP2 GARIN2	2.33e-04	225	85	5	25277244
Pubmed	Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome.	PURA SAFB2 TP53BP1	2.39e-04	49	85	3	27352031
Pubmed	Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma.	IGFBP1 IL6ST	2.62e-04	10	85	2	19124510
Pubmed	Predominant expression of H3K9 methyltransferases in prehypertrophic and hypertrophic chondrocytes during mouse growth plate cartilage development.	SETDB1 PRDM2	2.62e-04	10	85	2	23333759
Pubmed	A staging system for correct phenotype interpretation of mouse embryos harvested on embryonic day 14 (E14.5).	PDS5B NF1 DBN1	2.70e-04	51	85	3	28185240
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SETD2 KIDINS220 POLR1A SBF1 CWC27 PURA HIP1R DAXX RAB11FIP1 WRAP53 ZMYM3 CUEDC1	2.78e-04	1497	85	12	31527615
Pubmed	Y chromosome damage underlies testicular abnormalities in ATR-X syndrome.	DAXX TP53BP1	3.20e-04	11	85	2	38616920
Pubmed	New nomenclature for chromatin-modifying enzymes.	SETDB1 SETD2 PRDM2	3.75e-04	57	85	3	18022353
Pubmed	Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair.	BSN TP53BP1	3.83e-04	12	85	2	28700933
Pubmed	SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer.	SETD2 DAXX	3.83e-04	12	85	2	31911863
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	ERCC5 POLR1A UBR5 PURA SRCAP INTS3	3.97e-04	390	85	6	17643375
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	RC3H2 SLK POLR1A SBF1 CWC27 TJP2 DAXX DBN1	3.99e-04	724	85	8	36232890
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SETD2 SLK OSBPL9 TJP2 DBN1 SRCAP TP53BP1	4.01e-04	549	85	7	38280479
Pubmed	Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system.	RC3H2 BCL11A ZMYM3	4.36e-04	60	85	3	29055695
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	DMXL2 NF1 UBR5 TJP2	4.76e-04	147	85	4	29576527
Pubmed	SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.	PDS5B POLR1A PEG10 PURA	5.13e-04	150	85	4	30154076
Pubmed	A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.	MIS18BP1 POU2F1	5.27e-04	14	85	2	10976766
Pubmed	The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.	SETDB1 PURA SAFB2	5.77e-04	66	85	3	32051553
Pubmed	POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.	KIZ RGS22 SAFB2 CMYA5 ARHGAP18	6.03e-04	277	85	5	30745168
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	DMXL2 NF1 UBR5 PURA DBN1	6.43e-04	281	85	5	28706196
Pubmed	Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.	DAXX WRAP53	6.93e-04	16	85	2	25416818
Pubmed	A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.	UBR5 UBE3A	6.93e-04	16	85	2	22496338
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	SBF1 UBR5 DBN1 TP53BP1	7.67e-04	167	85	4	25659891
Pubmed	A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells.	TJP2 BCL11A ZMYM3	7.74e-04	73	85	3	22094256
Pubmed	Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice.	IGFBP1 IFNAR2	7.84e-04	17	85	2	9175833
Pubmed	Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.	MIS18BP1 PEG10 TJP2 SNX19	8.02e-04	169	85	4	31462741
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	ZNF106 SETD2 UBR5 AIFM1 INTS3 TP53BP1	8.68e-04	453	85	6	29656893
Pubmed	Serological detection of cutaneous T-cell lymphoma-associated antigens.	SLK UBE3A	8.80e-04	18	85	2	11149944
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	NF1 LRRC37A3 UBE3A USH1G BCORL1 BSN INTS3	9.70e-04	638	85	7	31182584
Pubmed	Secreted retrovirus-like GAG-domain-containing protein PEG10 is regulated by UBE3A and is involved in Angelman syndrome pathophysiology.	UBE3A PEG10	9.83e-04	19	85	2	34467244
Pubmed	Genes, plasticity and mental retardation.	NF1 UBE3A	9.83e-04	19	85	2	18329113
Pubmed	SHARPIN negatively associates with TRAF2-mediated NFκB activation.	ZNF106 AIFM1	9.83e-04	19	85	2	21829440
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DMXL2 KIDINS220 SBF1 UBR5 AIFM1 PEG10 RAB11FIP1 TIMMDC1 SNX19 PUS7 TP53BP1	9.84e-04	1487	85	11	33957083
Pubmed	Functional specialization of beta-arrestin interactions revealed by proteomic analysis.	POLR1A UBR5 BACH2 DBN1 BSN	1.10e-03	317	85	5	17620599
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	SETDB1 ERCC5 UBR5 UBE3A LMTK2 CUEDC1	1.18e-03	481	85	6	28190767
Pubmed	Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis.	UBR5 TP53BP1	1.20e-03	21	85	2	30179224
Pubmed	Phosphorylation of the chromatin remodeling factor DPF3a induces cardiac hypertrophy through releasing HEY repressors from DNA.	UBR5 AIFM1	1.20e-03	21	85	2	26582913
Pubmed	Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.	UBR5 UBE3A TP53BP1	1.20e-03	85	85	3	16051665
Pubmed	Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.	NF1 BSN TP53BP1	1.25e-03	86	85	3	10862698
Pubmed	Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.	SBF1 UBR5 AIFM1	1.29e-03	87	85	3	17148452
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	PDS5B SETD2 DMXL2 KIDINS220 SBF1 SAFB2 DBN1 SRCAP ZMYM3	1.31e-03	1082	85	9	38697112
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ERCC5 OBSCN SAFB2 LMTK2 TJP2 SRCAP CPLANE1 TP53BP1 PRDM2	1.33e-03	1084	85	9	11544199
Pubmed	NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.	DMXL2 OBSCN OSBPL9 DBN1 ZMYM3	1.37e-03	333	85	5	32665550
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	PRUNE2 SETD2 POLR1A CCNB3 DAXX SNX19	1.38e-03	496	85	6	31343991
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	PDS5B ZNF106 POLR1A OBSCN TJP2 AK9	1.39e-03	497	85	6	36774506
Pubmed	Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.	SBF1 BACH2 LRRTM4 IL6ST	1.47e-03	199	85	4	23382691
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	PDS5B UBR5 BCORL1 SAFB2 POU2F1 BCL11A ZMYM3 TP53BP1 PRDM2	1.50e-03	1103	85	9	34189442
Pubmed	Whole-genome sequencing reveals host factors underlying critical COVID-19.	BCL11A IFNAR2	1.71e-03	25	85	2	35255492
Pubmed	PIDD orchestrates translesion DNA synthesis in response to UV irradiation.	ERCC5 AIFM1	1.71e-03	25	85	2	21415862
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	KIDINS220 AIFM1 BSN PRDM2	1.72e-03	208	85	4	33230847
Pubmed	Interaction network of human early embryonic transcription factors.	BCORL1 POU2F1 BCL11A ZMYM3 PRDM2	1.73e-03	351	85	5	38297188
Pubmed	ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress.	SETD2 DAXX	1.85e-03	26	85	2	34162889
Interaction	SIRT6 interactions	SETDB1 SETD2 NF1 POLR1A SBF1 UBR5 UBE3A AIFM1 LMTK2 DAXX SRCAP TP53BP1	8.53e-06	628	82	12	int:SIRT6
Cytoband	17q21.31	LRRC37A LRRC37A2 ARHGAP27 SPATA32	1.71e-05	82	85	4	17q21.31
Cytoband	14q21.2	MIS18BP1 FSCB	6.30e-04	20	85	2	14q21.2
Cytoband	Xp22	VCX3A VCX	9.89e-04	25	85	2	Xp22
Cytoband	Ensembl 112 genes in cytogenetic band chrXp22	VCX2 VCX3A VCX3B VCX	1.23e-03	250	85	4	chrXp22
GeneFamily	Variable charge X/Y family	VCX2 VCX3A VCX3B VCX	1.42e-09	6	58	4	368
GeneFamily	Fibronectin type III domain containing	TSPOAP1 OBSCN CMYA5 CNTN2 IL6ST	1.60e-04	160	58	5	555
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETDB1 SETD2 PRDM2	1.75e-04	34	58	3	487
Coexpression	JAZAG_TGFB1_SIGNALING_VIA_SMAD4_UP	ERCC5 TSPOAP1 DAXX SRCAP VCX	2.61e-05	107	85	5	M13424
Coexpression	GSE19401_UNSTIM_VS_PAM2CSK4_STIM_FOLLICULAR_DC_UP	NF1 SBF1 PURA POU2F1 UST TP53BP1	4.46e-05	197	85	6	M7670
Coexpression	GSE22886_NAIVE_BCELL_VS_MONOCYTE_UP	MS4A1 LRRC37A3 PEG10 BACH2 BCL11A UST	4.46e-05	197	85	6	M4485
Coexpression	GSE22886_NAIVE_BCELL_VS_DC_UP	MS4A1 LRRC37A3 PEG10 BACH2 BCL11A WRAP53	4.59e-05	198	85	6	M4483
Coexpression	GSE11864_UNTREATED_VS_CSF1_IFNG_IN_MAC_DN	AIFM1 LRRC37A2 TJP2 DAXX TIMMDC1 IL6ST	4.85e-05	200	85	6	M3127
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	SETD2 OBSCN POU2F1 CPLANE1 INTS3 GRAMD1C NEK11	3.18e-08	166	85	7	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	COPD-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	MS4A1 BACH2 BCL11A RAB11FIP1 UST GRAMD1C PRDM2	8.01e-08	190	85	7	1e85ee686ff6dd27c69415d524d54fa825b1daad
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCL11A ARHGAP18 RAB11FIP1 BSN WRAP53 UST	7.38e-07	164	85	6	54f8f11d2fa899005530c08e7a1ee728c7b0799c
ToppCell	normal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells\|normal_Lymph_Node / Location, Cell class and cell subclass	LRRC37A LRRC37A3 BCL11A ARHGAP27 NME8 CUEDC1	1.08e-06	175	85	6	29fbdfe1d3bfcb063be2bced0128a33176c5b78f
ToppCell	3'_v3-Lung-Lymphocytic_B\|Lung / Manually curated celltypes from each tissue	MS4A1 PEG10 BACH2 BCL11A GRAMD1C PRDM2	1.27e-06	180	85	6	237a2130a3f48595dad2417539c21e44585962b8
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MS4A1 PEG10 BACH2 HIP1R BCL11A PRDM2	1.63e-06	188	85	6	d8decd9b5967873ca8320c2f9f07365f163c777f
ToppCell	Fetal_29-31_weeks-Immune-B_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MIS18BP1 MS4A1 BACH2 HIP1R BCL11A PRDM2	1.74e-06	190	85	6	424550418c1bd4eb070cf3c41cf09fa9d89aef37
ToppCell	COVID_non-vent-Lymphocytic-B_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	MS4A1 PEG10 BACH2 HIP1R BCL11A PRDM2	1.90e-06	193	85	6	32d139f922cd19adc1cc1e0e9a828115be9945d6
ToppCell	COVID_non-vent-Lymphocytic-B_cell-\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	MS4A1 PEG10 BACH2 HIP1R BCL11A PRDM2	1.90e-06	193	85	6	91955c3773c9729a96e82f240f06b072367970d9
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MS4A1 PEG10 BACH2 HIP1R BCL11A PRDM2	1.96e-06	194	85	6	24f9de4781666c96c4a2d04f8a444543dbd99cbe
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MS4A1 BACH2 HIP1R BCL11A RAB11FIP1 PRDM2	1.96e-06	194	85	6	d852aebf7a763b9a776c4570711f0c759f591910
ToppCell	10x5'-bone_marrow-Lymphocytic_B\|bone_marrow / Manually curated celltypes from each tissue	MS4A1 PEG10 BACH2 HIP1R BCL11A PRDM2	2.02e-06	195	85	6	bcbf0305ca9337a6f3021178dbb47a7fbf1030a4
ToppCell	Influenza_Severe-B_naive\|Influenza_Severe / Disease group and Cell class	MS4A1 PEG10 BACH2 HIP1R BCL11A PRDM2	2.02e-06	195	85	6	a25516ed670c7738670ffbaa6f7cd167946f3825
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	INTU RGS22 AK9 DLEC1 CPLANE1 NEK11	2.14e-06	197	85	6	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MS4A1 PEG10 BACH2 HIP1R BCL11A PRDM2	2.14e-06	197	85	6	5c67ed18fb92aec73c79f4db6d80cec777d9ba44
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	MS4A1 PEG10 BACH2 HIP1R BCL11A PRDM2	2.14e-06	197	85	6	368a7908435cb0d0feea135345e7179584a1e0cf
ToppCell	COVID-19_Mild-Lymphoid_B\|COVID-19_Mild / Disease group, lineage and cell class	MS4A1 PEG10 BACH2 HIP1R BCL11A PRDM2	2.14e-06	197	85	6	ff25c0e184bd0f068014bc3f5eba3aee17511b87
ToppCell	mild-B_memory\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MIS18BP1 MS4A1 HIP1R BCL11A GRAMD1C PRDM2	2.27e-06	199	85	6	e6ac9a0959b0de2c6a99298feb7715aa80ade1dd
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-B-B_naive\|COVID-19_Mild / Disease, condition lineage and cell class	MS4A1 PEG10 BACH2 HIP1R BCL11A PRDM2	2.34e-06	200	85	6	e6a43eff47195e1d39530ad49ad908fc06a8b038
ToppCell	NS-moderate-d_0-4-Epithelial\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ZNF106 SLK TJP2 ARHGAP18 RAB11FIP1 CPLANE1	2.34e-06	200	85	6	64462a18afca3c1a8548a857924b8166058bf958
ToppCell	Influenza-Influenza_Severe-Lymphocyte-B-B_naive\|Influenza_Severe / Disease, condition lineage and cell class	MS4A1 PEG10 BACH2 HIP1R BCL11A PRDM2	2.34e-06	200	85	6	0e05600d725dc5cc9afccc11eedc60efa41e4e46
ToppCell	severe-B_naive\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MS4A1 PEG10 BACH2 HIP1R BCL11A PRDM2	2.34e-06	200	85	6	0e86f52b6e146d9bbc728d8fb176fc2b53696558
ToppCell	mild-B_naive\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MS4A1 PEG10 BACH2 HIP1R BCL11A PRDM2	2.34e-06	200	85	6	222789b897e2a683bbfd1d00b6fd8705015d90df
ToppCell	Influenza-Influenza_Severe-Lymphocyte-B\|Influenza_Severe / Disease, condition lineage and cell class	MS4A1 PEG10 BACH2 HIP1R BCL11A PRDM2	2.34e-06	200	85	6	bf238a0a074d6c5cba8cb73d3b715ee701a612b6
ToppCell	mild-B_naive\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MS4A1 PEG10 BACH2 HIP1R BCL11A PRDM2	2.34e-06	200	85	6	d0467cab6a42bf780aa49046bf3231ca161dc144
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-9\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MS4A1 PEG10 BACH2 HIP1R BCL11A	1.02e-05	150	85	5	d9931507257c64ead4a53786e6822f51962c6015
ToppCell	tumor_Lymph_Node_/_Brain-B_lymphocytes-Undetermined\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	LRRC37A MS4A1 BACH2 BCL11A PRDM2	1.16e-05	154	85	5	e16f200391537aa1002b0079481b94e1fb86b9ad
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	MS4A1 HIP1R BCL11A RAB11FIP1 PRDM2	1.52e-05	163	85	5	6bed27d2f67a430a847da5eb47878d14b4949c45
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC1-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TSPOAP1 BCL11A ARHGAP27 RAB11FIP1 NME8	1.66e-05	166	85	5	c8a7d94ed762e5e045ab5f74eef691ddc5f74993
ToppCell	Children_(3_yrs)-Immune-B_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MS4A1 BACH2 HIP1R BCL11A GRAMD1C	1.87e-05	170	85	5	e421f9eedf74baffda1d03707a710ece4b777f29
ToppCell	3'_v3-Lung-Lymphocytic_B-Memory_B_cells\|Lung / Manually curated celltypes from each tissue	MS4A1 PEG10 BCL11A GRAMD1C PRDM2	1.92e-05	171	85	5	9ecef653f6916572bf5fbee5aea6c577d04e96ba
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MS4A1 PEG10 BACH2 BCL11A PRDM2	1.97e-05	172	85	5	62ed3b70fa1f6c84ea80ff00f60d2562be292e9d
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	MS4A1 HIP1R BCL11A RAB11FIP1 PRDM2	2.03e-05	173	85	5	d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCell	Control-Lymphocyte-B-B_naive\|Control / Disease, Lineage and Cell Type	MS4A1 PEG10 BACH2 HIP1R BCL11A	2.39e-05	179	85	5	35994281904bfe38766e715ab608211a5ca865a9
ToppCell	Severe-Lymphoid-B\|Severe / Condition, Lineage, Cell class and cell subclass	MS4A1 BACH2 HIP1R BCL11A GRAMD1C	2.45e-05	180	85	5	67ffaf5096f025c3c61fffe52f6c8a96f120fc6f
ToppCell	Severe-Lymphoid-B-\|Severe / Condition, Lineage, Cell class and cell subclass	MS4A1 BACH2 HIP1R BCL11A GRAMD1C	2.45e-05	180	85	5	fd3eb751704b14ff1500e4bd041441644d233e9c
ToppCell	severe_influenza-B_memory\|severe_influenza / disease group, cell group and cell class (v2)	MS4A1 HIP1R VSIG1 BCL11A GRAMD1C	2.52e-05	181	85	5	92e572c92109a6dae0f73138c57c3bbd2e0a2f36
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-8\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MS4A1 PEG10 BACH2 HIP1R BCL11A	2.52e-05	181	85	5	ca34d83daca10c5fa52ecdf4eba7d31b4e7e056e
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	MS4A1 PEG10 BACH2 HIP1R BCL11A	2.59e-05	182	85	5	862cc68006918e9e46e22b236302d862737f1061
ToppCell	Influenza_Severe-B_naive\|World / Disease group and Cell class	MS4A1 PEG10 BACH2 HIP1R BCL11A	2.59e-05	182	85	5	e4885a5e6065c9c403cb2d305228691d6ae4ecb6
ToppCell	Severe_COVID-19-B_cell-B_cell\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	MS4A1 BACH2 HIP1R BCL11A GRAMD1C	2.66e-05	183	85	5	5634e528001c389efd1e380f01ad40072f60e943
ToppCell	COPD-Lymphoid-B\|COPD / Disease state, Lineage and Cell class	MS4A1 BACH2 BCL11A GRAMD1C PRDM2	2.80e-05	185	85	5	925e79c35c381dd44ec5fb921dca09ce43140135
ToppCell	COVID-19-lung-B_cells\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MS4A1 BACH2 BCL11A UST PRDM2	2.80e-05	185	85	5	e8f1ad580f19705b5ca1d7d8867b2125f4891684
ToppCell	COPD-Lymphoid-B\|World / Disease state, Lineage and Cell class	MS4A1 BACH2 BCL11A GRAMD1C PRDM2	2.80e-05	185	85	5	22891ed75e25ef30dfa541cb82d85e08ce07e7d9
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-lymphocytic-B_lymphocytic-memory_B_cell\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MS4A1 PEG10 BACH2 BCL11A GRAMD1C	2.95e-05	187	85	5	b5cb8760fa667c237902d50a78dea4cb1babd607
ToppCell	Healthy_donor-B_memory\|World / disease group, cell group and cell class (v2)	MS4A1 HIP1R BCL11A GRAMD1C PRDM2	2.95e-05	187	85	5	4f68e3243071a4549c80aff8bff32c6ad892ee7f
ToppCell	Immune-B_cell\|World / Lineage, Cell type, age group and donor	MS4A1 BACH2 HIP1R BCL11A PRDM2	2.95e-05	187	85	5	795690c6306c366e733279491138d0cd9b469b21
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-8\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MS4A1 PEG10 BACH2 HIP1R BCL11A	2.95e-05	187	85	5	c10d6a774b3e83f64e47b9ad08f5d6b0dc60d163
ToppCell	IPF-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	MS4A1 BACH2 BCL11A UST PRDM2	2.95e-05	187	85	5	af1327559f7e01bec070881cae52834917c3da65
ToppCell	B_cells-Naive_B_cells_\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	MS4A1 BACH2 BCL11A RAB11FIP1 PRDM2	3.02e-05	188	85	5	d1bc1316bbb8cfc39acc70f8680b14d19f536997
ToppCell	normal-na-Lymphocytic_B-B_naive-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	MS4A1 PEG10 BACH2 BCL11A PRDM2	3.02e-05	188	85	5	ec72ba73b10c6f2ff39699b6b46b90a3e95a4c24
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MS4A1 BACH2 HIP1R BCL11A RAB11FIP1	3.10e-05	189	85	5	b13f315f617840eb5143a4e8a33a657c20365c21
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MS4A1 PEG10 HIP1R BCL11A RAB11FIP1	3.18e-05	190	85	5	60bb6aaea9691d07295f61c14d1650f5041a0f9c
ToppCell	B_cell_maturation\|World / Lineage and Cell class	MS4A1 PEG10 BACH2 BCL11A PRDM2	3.18e-05	190	85	5	301782283d0c604fb3b428a8ddf1f7cd8e63a90b
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_memory-B_memory-0\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MS4A1 HIP1R BCL11A GRAMD1C PRDM2	3.18e-05	190	85	5	95b9334573eefb132daaa9371377ad60232006ae
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	MS4A1 BACH2 HIP1R BCL11A PRDM2	3.18e-05	190	85	5	0724665ac8238f2383c3a929d89abf4a48ec2420
ToppCell	Fetal_29-31_weeks-Immune-B_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MS4A1 BACH2 HIP1R BCL11A PRDM2	3.26e-05	191	85	5	84452125d1b5b76974e3f9126f611eff16d45c25
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_memory\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MS4A1 HIP1R BCL11A GRAMD1C PRDM2	3.26e-05	191	85	5	22134a2c1a92208bc1629a620ce73a56502613c2
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MS4A1 BACH2 HIP1R BCL11A PRDM2	3.34e-05	192	85	5	446c61c0d6ba89c619efe87ee495951299953981
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-2\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MS4A1 BACH2 HIP1R BCL11A PRDM2	3.34e-05	192	85	5	ef86d82e4f04f9f54e821ef496d70fc81072d773
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_memory-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MS4A1 HIP1R BCL11A GRAMD1C PRDM2	3.34e-05	192	85	5	debd471f61cf3606b8e9c246add0be5df601af7f
ToppCell	Healthy-B_naive\|Healthy / disease group, cell group and cell class	MS4A1 PEG10 BACH2 HIP1R BCL11A	3.34e-05	192	85	5	5fddf679dcc9c0077d6bfe04c1e602863fb959eb
ToppCell	B_cell_maturation-Naive_B_cell\|World / Lineage and Cell class	MS4A1 PEG10 BACH2 BCL11A PRDM2	3.34e-05	192	85	5	58267a11c938a380c6e26f4e4ce63f3b4be79fdc
ToppCell	COVID-19_Mild-Lymphoid_B-B_memory\|COVID-19_Mild / Disease group, lineage and cell class	MS4A1 HIP1R BCL11A GRAMD1C PRDM2	3.34e-05	192	85	5	d27db7669de95bddbea8ccb83e6f10ae7240b1ab
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_memory\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MS4A1 HIP1R BCL11A GRAMD1C PRDM2	3.34e-05	192	85	5	314f74dd3c6d94839eed05b9a1a398217ef78029
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MS4A1 PEG10 BACH2 HIP1R BCL11A	3.34e-05	192	85	5	800edadd1d1ba6b7e0a0398030dd4b61c9c480c7
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	MS4A1 BACH2 HIP1R BCL11A PRDM2	3.42e-05	193	85	5	ac227ddabfb3f021b1b39dba73f898517cd5a58e
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-9\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MS4A1 BACH2 HIP1R BCL11A PRDM2	3.42e-05	193	85	5	d5d188a314da1b4c8390276d88173c09dd7ce4bf
ToppCell	severe_influenza-B_naive\|World / disease group, cell group and cell class (v2)	MS4A1 PEG10 BACH2 HIP1R BCL11A	3.42e-05	193	85	5	c52ba94782ad57b93d20f853a89344dffa8351f9
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	MS4A1 BACH2 HIP1R BCL11A PRDM2	3.42e-05	193	85	5	f4135615ee0118eec9e221becdd67888e0c2a112
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	MS4A1 BACH2 HIP1R BCL11A PRDM2	3.51e-05	194	85	5	5cd72330c9d9bb21b6c9d5d35085eade101486d1
ToppCell	severe_influenza-B_naive\|severe_influenza / disease group, cell group and cell class (v2)	MS4A1 PEG10 BACH2 HIP1R BCL11A	3.51e-05	194	85	5	7c1e9ce5de3bb1657a67010de673c8bb60129cb6
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MS4A1 PEG10 BACH2 HIP1R BCL11A	3.51e-05	194	85	5	82753b90ca3b563275c41b6040ebbcd99b185e24
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-8\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MS4A1 PEG10 BACH2 HIP1R BCL11A	3.51e-05	194	85	5	e9c907b8ec4329946338cca5ce8e954fa2cec37b
ToppCell	Control-Lymphoid_B-B_naive\|Control / Disease group, lineage and cell class	MS4A1 PEG10 BACH2 HIP1R BCL11A	3.51e-05	194	85	5	4f9600960a287cfc020c06b4af3528d4e5797916
ToppCell	COVID-19_Severe-B_naive\|World / disease group, cell group and cell class	MS4A1 PEG10 BACH2 HIP1R BCL11A	3.51e-05	194	85	5	d363963a6caeedf4f9e9ad22dcf9b66b85c79a48
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)\|390C / Donor, Lineage, Cell class and subclass (all cells)	UBR5 PEG10 LRRC37A2 ARHGAP27 TP53BP1	3.51e-05	194	85	5	88db9f9e80c20ff3474f1f6459dcbdc25aec0b6d
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	UBR5 PEG10 LRRC37A2 ARHGAP27 TP53BP1	3.51e-05	194	85	5	a71728202493d4858342ea2756ea281cd0d99a3a
ToppCell	PBMC-Mild-Lymphocyte-B\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	MS4A1 BACH2 HIP1R BCL11A PRDM2	3.51e-05	194	85	5	b16b96e42ea9734731342d4c41ff1711bd149462
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	INTU RGS22 AK9 DLEC1 NEK11	3.51e-05	194	85	5	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MS4A1 HIP1R BCL11A RAB11FIP1 PRDM2	3.60e-05	195	85	5	481989d2e5bd2582da3d86b0155c4d6615317067
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MS4A1 BACH2 HIP1R BCL11A PRDM2	3.60e-05	195	85	5	0c49d22c348aec6d8a1a976e7c88d0a3b48a4244
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MS4A1 HIP1R BCL11A RAB11FIP1 PRDM2	3.60e-05	195	85	5	6108a27523d1b93a7fbe35cb95704a5ad9071e3c
ToppCell	Healthy_donor-B_naive\|World / disease group, cell group and cell class (v2)	MS4A1 BACH2 HIP1R BCL11A PRDM2	3.60e-05	195	85	5	c66bbfdf0091cc62aa50edfa88820bbda191b7bb
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MS4A1 PEG10 BACH2 HIP1R BCL11A	3.60e-05	195	85	5	8f5a664dd65c38afe23c6acd0a9c22ba4fd347ed
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	MS4A1 PEG10 BACH2 HIP1R BCL11A	3.60e-05	195	85	5	e830f0c545be87a1056a4505bdf6845e5ac7750d
ToppCell	mild_COVID-19_(asymptomatic)-B_naive\|World / disease group, cell group and cell class (v2)	MS4A1 BACH2 HIP1R BCL11A PRDM2	3.60e-05	195	85	5	e763d9a431052c03cc6d514f2736506c6667e2be
ToppCell	COVID-19_Severe-Lymphoid_B-B_naive\|COVID-19_Severe / Disease group, lineage and cell class	MS4A1 PEG10 BACH2 HIP1R BCL11A	3.60e-05	195	85	5	71563e838fcda34a9a209c5433e0d84420373402
ToppCell	mild_COVID-19_(asymptomatic)-B_naive\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	MS4A1 BACH2 HIP1R BCL11A PRDM2	3.69e-05	196	85	5	c87499aa570f8fab878c4c015e47c711a3a21e9c
ToppCell	mild_COVID-19-B_naive\|mild_COVID-19 / disease group, cell group and cell class (v2)	MS4A1 BACH2 HIP1R BCL11A PRDM2	3.69e-05	196	85	5	00398079d3ac14dc2026c0cbd7388f1f3257b134
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MS4A1 PEG10 BACH2 HIP1R BCL11A	3.69e-05	196	85	5	d7e6c89cb49933b4a86d26d15f6772f2481d37ef
ToppCell	COVID-19_Mild-Lymphoid_B-B_naive\|COVID-19_Mild / Disease group, lineage and cell class	MS4A1 BACH2 HIP1R BCL11A PRDM2	3.69e-05	196	85	5	4b3ceb1f85be0fa8d53dc5548326ab0a5239a8b9
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	MS4A1 BACH2 HIP1R BCL11A PRDM2	3.69e-05	196	85	5	c225c8eb2fe9a10f0cf574c7d8b6206887aac2df
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MS4A1 PEG10 BACH2 HIP1R BCL11A	3.69e-05	196	85	5	fcbfd8c4771d99a45fc53e482ef98edabe8ef591
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	MS4A1 PEG10 BACH2 HIP1R BCL11A	3.69e-05	196	85	5	f45cb8f714ae7ac800768df65f299b98a2d42962
ToppCell	control-B_naive\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MS4A1 PEG10 BACH2 HIP1R BCL11A	3.78e-05	197	85	5	559650fb53f18ecae4cfaa8221e978ae3fb63e06
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MS4A1 BACH2 HIP1R BCL11A PRDM2	3.78e-05	197	85	5	f7a8440d2b8b17d9726c6fe3dd383effbfebab13
ToppCell	B_cells-Naive_B_cells_\|B_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	MS4A1 BACH2 BCL11A RAB11FIP1 PRDM2	3.78e-05	197	85	5	fd5fdc5289d681d59ff22d72e4de6e74c6c7aac6
ToppCell	COVID-19_Severe-Lymphoid_B\|COVID-19_Severe / Disease group, lineage and cell class	MS4A1 PEG10 BACH2 HIP1R BCL11A	3.78e-05	197	85	5	25303329b051831cf2ed4df68f3948308e5fbd96
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-2\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MS4A1 PEG10 BACH2 HIP1R BCL11A	3.78e-05	197	85	5	20dcb006df86bbeb4a2e598aae8f15b349c7b6a6
Drug	Fenbufen [36330-85-5]; Down 200; 15.8uM; PC3; HT_HG-U133A	SETD2 MIS18BP1 NF1 BACH2 BCL11A IL6ST IFNAR2	7.44e-06	191	85	7	4279_DN
Drug	CGX 0596987; Down 200; 20uM; PC3; HT_HG-U133A	PDS5B SETDB1 SBF1 SAFB2 WRAP53 SRCAP CPLANE1	8.24e-06	194	85	7	6417_DN
Drug	Bufexamac [2438-72-4]; Down 200; 18uM; HL60; HT_HG-U133A	SETDB1 SETD2 KIDINS220 NF1 BCORL1 SRCAP PRDM2	8.81e-06	196	85	7	2382_DN
Disease	Malignant neoplasm of breast	SETD2 NF1 LRRC37A BCORL1 LRRC37A2 OBSCN POU2F1 DLEC1 BCL11A DBN1 FSCB NME8 TP53BP1	7.95e-06	1074	82	13	C0006142
Disease	Recurrent infections	MS4A1 IL6ST	7.59e-05	5	82	2	C0239998
Disease	lung non-small cell carcinoma (is_marker_for)	NF1 UBR5 BCORL1 BCL11A WRAP53	1.11e-04	169	82	5	DOID:3908 (is_marker_for)
Disease	Adenoid Cystic Carcinoma	SETD2 BCORL1 BCL11A SRCAP	1.77e-04	100	82	4	C0010606
Disease	QRS duration	PDS5B UBR5 CWC27 OLFML2B DLEC1 FSCB	1.86e-04	298	82	6	EFO_0005055
Disease	asthma, Eczema, allergic rhinitis	LAYN TCHHL1 BACH2 ARHGAP27	3.68e-04	121	82	4	EFO_0005854, HP_0000964, MONDO_0004979
Disease	attention deficit hyperactivity disorder, autism spectrum disorder, intelligence	DMXL2 KIZ BCL11A DBN1 BSN PUS7	8.57e-04	398	82	6	EFO_0003756, EFO_0003888, EFO_0004337
Disease	Abnormal behavior	BCORL1 PUS7	8.93e-04	16	82	2	C0233514
Disease	transient cerebral ischemia (biomarker_via_orthology)	NF1 AIFM1 DAXX DBN1	9.77e-04	157	82	4	DOID:224 (biomarker_via_orthology)
Disease	Glioblastoma	NF1 DAXX TP53BP1	1.40e-03	79	82	3	C0017636
Disease	Intellectual Disability	SETD2 NF1 PURA BCL11A FHIP2A PUS7	1.55e-03	447	82	6	C3714756
Disease	Neurodevelopmental Disorders	SETD2 PURA SRCAP	2.24e-03	93	82	3	C1535926
Disease	lung carcinoma	PDS5B SLK LRRTM4 AK9 DLEC1 TP53BP1	2.26e-03	482	82	6	EFO_0001071

Protein segments in the cluster

Peptide	Gene	Start	Entry
LDEDLEPETSPLETF	USH1G	381	Q495M9
KSEPPSEENEEESIT	BACH2	276	Q9BYV9
DLQEDVEENPSPTVE	GRAMD1C	21	Q8IYS0
AETPENDIPETEVED	CWC27	401	Q6UX04
ESETESEASEITIPP	AIFM1	531	O95831
SQEVFPTEEEEEVTP	BCORL1	1246	Q5H9F3
LTPQEEDDPEGDTEV	DMXL2	2021	Q8TDJ6
PIQEEEEEETETNFP	MS4A1	266	P11836
EEDCPELVPIETTQS	CBWD5	16	Q5RIA9
QPEELTLEEESPVSQ	DAXX	551	Q9UER7
TPKEITPREDIDEDS	CCNB3	1106	Q8WWL7
TDEPDGQSEPIEEIL	RC3H2	1066	Q9HBD1
SSPVDDIPQEETEEE	PDS5B	1416	Q9NTI5
PTPEVDTASEVEELE	TSPOAP1	621	O95153
LPEEITEESLEESVG	INTS3	636	Q68E01
DTEENTELVSEGPVP	OSBPL9	471	Q96SU4
QEEDSTVLIDVSPPE	ANO7	61	Q6IWH7
SPLDPITEEDEKSDQ	KIDINS220	1471	Q9ULH0
TSTELIIEPEEPSDS	LRRC37A3	1081	O60309
SNIPVILEPETEESE	MIS18BP1	811	Q6P0N0
TSTELIVEPEEPSDS	LRRC37A2	1081	A6NM11
TSTELIVEPEEPSDS	LRRC37A	1081	A6NMS7
ETVSPEQDESPGLEL	LRRTM4	551	Q86VH4
EVQSLPAEETPIEET	FSCB	681	Q5H9T9
EETELTTPVLPEETQ	LAYN	201	Q6UX15
GPLLPTIEDSSEEEE	BSN	1031	Q9UPA5
EFSPEPLEAILTDDE	BCL11A	16	Q9H165
EEDCPELVPIETTQS	CBWD1	16	Q9BRT8
PESPESTEITEEELL	IGFBP1	121	P08833
PEILERTLEPDSSDE	CUEDC1	111	Q9NWM3
NTTLREQVEPTPEDE	PEG10	41	Q86TG7
REEESDEPTLENLPE	NEK11	426	Q8NG66
EPSLETPDSLESVDV	LMTK2	991	Q8IWU2
ETQEPSPILDSEETR	DBN1	376	Q16643
SISEDDLILESPEPQ	KIZ	381	Q2M2Z5
TPSLEEPSDLEELEQ	POU2F1	276	P14859
ESQLIDPESEEEPDL	IFNAR2	356	P48551
PPEDQEDEISVSEEL	SBF1	1086	O95248
SEDEEESLLPETPTV	INTU	71	Q9ULD6
REPTLDSISELPEED	OBSCN	4751	Q5VST9
EDEEPENLIEISTGP	HIP1R	311	O75146
ESTQPLLDSEERPED	IL6ST	781	P40189
ETTPLAENQDEDPLE	C6orf52	91	Q5T4I8
SLLQDLSPTEEEEPE	CPLANE1	3136	Q9H799
AITPEPEDSNLVEEE	CMYA5	516	Q8N3K9
EEDCPELVPIETTQS	CBWD3	16	Q5JTY5
EEDCPELVPIETTQS	CBWD6	16	Q4V339
DQPLSVLFPEESTEE	CNTN2	41	Q02246
PPIDLADIEDLSEDT	C9orf40	161	Q8IXQ3
EEDPLFTDISPENTL	FHIP2A	526	Q5W0V3
LEEVPEPVSSEAESL	DLEC1	716	Q9Y238
PEDLLEEPKTTSEET	PRDM2	316	Q13029
QSLPEDPLETSKEEE	PRDM2	1246	Q13029
TDITDVTDLPENEVP	GARIN2	241	Q8N9W8
ETEPEAVSEPIEETT	AK9	776	Q5TCS8
SLELEESLPEQPETG	RAB11FIP1	686	Q6WKZ4
EEPLSQESEVEEPLS	VCX3A	111	Q9NNX9
EEPLSQESQVEEPLS	VCX3A	121	Q9NNX9
EEPLSQESEVEEPLS	VCX3A	131	Q9NNX9
EEPLSQESQVEEPLS	VCX3A	141	Q9NNX9
EEPLSQESEVEEPLS	VCX3A	151	Q9NNX9
EEPLSQESQVEEPLS	VCX3A	161	Q9NNX9
LEENPDPSASEIREE	POLR1A	146	O95602
LPEEVATPTTDEEKD	POLR1A	351	O95602
EDEEEETENSLPIPA	SLK	321	Q9H2G2
EEPLSQESEVEEPLS	VCX3B	111	Q9H321
EEPLSQESQVEEPLS	VCX3B	121	Q9H321
EEPLSQESEVEEPLS	VCX3B	131	Q9H321
EEPLSQESQVEEPLS	VCX3B	141	Q9H321
EEPLSQESEVEEPLS	VCX3B	151	Q9H321
EEPLSQESEVEEPLS	VCX3B	161	Q9H321
EEPLSQESQVEEPLS	VCX3B	171	Q9H321
EEPLSQESEVEEPLS	VCX3B	181	Q9H321
EEPLSQESQVEEPLS	VCX3B	191	Q9H321
EEPLSQESQVEEPLS	VCX3B	211	Q9H321
PSELSPRIEEQELSE	WRAP53	86	Q9BUR4
SSELCLTEPEIDEEP	PRUNE2	2131	Q8WUY3
LTAEPPTITEEEFED	RGS22	6	Q8NE09
IDIESEDFSSLPPEV	ERCC5	186	P28715
IQELSAELPPEESES	ARHGAP27	611	Q6ZUM4
LNDLSIPVDEEDPSE	PUS7	151	Q96PZ0
STEPLLTTVEEREPE	SPATA32	276	Q96LK8
DEPLQEPLEADRTSE	SRCAP	2661	Q6ZRS2
SPTLSPEEEDDIRNV	OLFML2B	476	Q68BL8
SSRPTEIIEIPDEDD	SETDB1	116	Q15047
TPLETEEPIDDEEQD	UST	381	Q9Y2C2
ELDEPAEEPLVSSIT	TJP2	936	Q9UDY2
DDEEPIPESSELTLQ	UBE3A	396	Q05086
IELELEPETQSELEP	VSIG1	346	Q86XK7
EEPLSQESEVEEPLT	VCX2	111	Q9H322
PEIPLVDSDSEVSEE	NME8	131	Q8N427
LPEKIESSLQEDEPE	TIMMDC1	246	Q9NPL8
VDPTRLEPSESLEEN	NF1	1321	P21359
TPDIEESLLEPENEK	SAFB2	201	Q14151
DPIPLDTEVTALSED	TP53BP1	1536	Q12888
EPQSPTEELSEAETE	SNX19	696	Q92543
EEPLSQESEVEEPLS	VCX	111	Q9H320
EEPLSQESQVEEPLS	VCX	121	Q9H320
EEPLSQESEVEEPLS	VCX	131	Q9H320
EEPLSQESQVEEPLS	VCX	141	Q9H320
EEPLSQESEVEEPLS	VCX	151	Q9H320
EEPLSQESQVEEPLS	VCX	161	Q9H320
EETPAPETDINLEVS	ARHGAP18	221	Q8N392
EEPINEETPSQDEEE	SETD2	1971	Q9BYW2
SLDEDNIPPEDDISV	ZNF677	46	Q86XU0
PVTSEEEDESPQELA	TCHHL1	741	Q5QJ38
VEEEPAELPEGTSLT	PURA	211	Q00577
EPDSDSSLEVLEIPN	ZNF106	1416	Q9H2Y7
PEVVDSTESIPVSDE	ZMYM3	251	Q14202
EGEEQPVLPEETESS	UBR5	2121	O95071