Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	vitamin binding	FASN ACACB NPC1L1 PC CYP2W1	1.22e-04	161	60	5	GO:0019842
GeneOntologyMolecularFunction	biotin binding	ACACB PC	1.32e-04	6	60	2	GO:0009374
GeneOntologyMolecularFunction	ligase activity, forming carbon-carbon bonds	ACACB PC	1.85e-04	7	60	2	GO:0016885
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	CYP51A1 FADS2 CYP2S1 KDM6A CYP2W1	2.91e-04	194	60	5	GO:0016705
GeneOntologyCellularComponent	ATPase inhibitor complex	MAGOH MAGOHB	2.51e-05	3	61	2	GO:1903503
GeneOntologyCellularComponent	exon-exon junction subcomplex mago-y14	MAGOH MAGOHB	2.51e-05	3	61	2	GO:1990501
GeneOntologyCellularComponent	exon-exon junction complex	MAGOH SAP18 MAGOHB	3.03e-05	21	61	3	GO:0035145
GeneOntologyCellularComponent	cluster of actin-based cell projections	DOCK4 NPC1L1 LRP2 SLC28A3 CDC14A	4.83e-04	223	61	5	GO:0098862
Domain	-	MAGOH MAGOHB	9.81e-06	2	59	2	3.30.1560.10
Domain	Mago_nashi	MAGOH MAGOHB	2.94e-05	3	59	2	IPR004023
Domain	Mago_nashi	MAGOH MAGOHB	2.94e-05	3	59	2	PF02792
Domain	Biotin_BS	ACACB PC	9.75e-05	5	59	2	IPR001882
Domain	Biotin_carb_C	ACACB PC	9.75e-05	5	59	2	SM00878
Domain	Biotin_carb_C	ACACB PC	9.75e-05	5	59	2	PF02785
Domain	Biotin_carboxylation_dom	ACACB PC	9.75e-05	5	59	2	IPR011764
Domain	Biotin_COase_C	ACACB PC	9.75e-05	5	59	2	IPR005482
Domain	BIOTIN	ACACB PC	9.75e-05	5	59	2	PS00188
Domain	BC	ACACB PC	9.75e-05	5	59	2	PS50979
Domain	Rudment_hybrid_motif	ACACB PC	1.46e-04	6	59	2	IPR011054
Domain	E-NPP	ENPP7 ENPP2	2.04e-04	7	59	2	IPR024873
Domain	CPSase_L_D2	ACACB PC	2.04e-04	7	59	2	PF02786
Domain	CbamoylP_synth_lsu-like_ATP-bd	ACACB PC	2.04e-04	7	59	2	IPR005479
Domain	BC-like_N	ACACB PC	2.04e-04	7	59	2	IPR005481
Domain	Biotin_carb_N	ACACB PC	2.04e-04	7	59	2	PF00289
Domain	Biotin_lipoyl	ACACB PC	3.48e-04	9	59	2	PF00364
Domain	Phosphodiest	ENPP7 ENPP2	4.34e-04	10	59	2	PF01663
Domain	Biotin_lipoyl	ACACB PC	4.34e-04	10	59	2	IPR000089
Domain	BIOTINYL_LIPOYL	ACACB PC	4.34e-04	10	59	2	PS50968
Domain	Phosphodiest/P_Trfase	ENPP7 ENPP2	4.34e-04	10	59	2	IPR002591
Domain	Cyt_P450_CS	CYP51A1 CYP2S1 CYP2W1	6.27e-04	53	59	3	IPR017972
Domain	Single_hybrid_motif	ACACB PC	6.34e-04	12	59	2	IPR011053
Domain	-	ACACB PC	7.48e-04	13	59	2	3.40.50.20
Domain	CYTOCHROME_P450	CYP51A1 CYP2S1 CYP2W1	7.76e-04	57	59	3	PS00086
Domain	-	CYP51A1 CYP2S1 CYP2W1	8.17e-04	58	59	3	1.10.630.10
Domain	p450	CYP51A1 CYP2S1 CYP2W1	8.17e-04	58	59	3	PF00067
Domain	ATP-grasp	ACACB PC	8.71e-04	14	59	2	IPR011761
Domain	PreATP-grasp_dom	ACACB PC	8.71e-04	14	59	2	IPR016185
Domain	ATP_GRASP	ACACB PC	8.71e-04	14	59	2	PS50975
Domain	Cyt_P450	CYP51A1 CYP2S1 CYP2W1	9.02e-04	60	59	3	IPR001128
Domain	-	ACACB PC	1.00e-03	15	59	2	3.30.1490.20
Domain	ATP_grasp_subdomain_1	ACACB PC	1.45e-03	18	59	2	IPR013815
Domain	-	ACACB PC	1.45e-03	18	59	2	3.30.470.20
Domain	PWWP	NSD3 HDGFL3	1.80e-03	20	59	2	SM00293
Domain	PWWP	NSD3 HDGFL3	2.38e-03	23	59	2	PF00855
Domain	PWWP_dom	NSD3 HDGFL3	2.38e-03	23	59	2	IPR000313
Domain	PWWP	NSD3 HDGFL3	2.59e-03	24	59	2	PS50812
Domain	ATP_grasp_subdomain_2	ACACB PC	4.30e-03	31	59	2	IPR013816
Domain	Alkaline_phosphatase_core	ENPP7 ENPP2	4.30e-03	31	59	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ENPP7 ENPP2	4.30e-03	31	59	2	IPR017849
Domain	-	ENPP7 ENPP2	4.30e-03	31	59	2	3.40.720.10
Pathway	WP_FATTY_ACID_BIOSYNTHESIS	FASN ACACB PC	6.17e-05	22	50	3	M39440
Pathway	WP_FATTY_ACID_BIOSYNTHESIS	FASN ACACB PC	7.07e-05	23	50	3	MM15885
Pathway	REACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS	FASN ACACB ENPP2 LRP2 PC	8.40e-05	127	50	5	M27093
Pathway	REACTOME_CHREBP_ACTIVATES_METABOLIC_GENE_EXPRESSION	FASN ACACB	3.41e-04	8	50	2	M26991
Pathway	WP_BIOTIN_METABOLISM_INCLUDING_IMDS	ACACB PC	4.37e-04	9	50	2	M40064
Pathway	REACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP	FASN ACACB CYP51A1	4.37e-04	42	50	3	M27172
Pathway	WP_OXIDATION_BY_CYTOCHROME_P450	CYP51A1 CYP2S1 CYP2W1	4.69e-04	43	50	3	MM15873
Pathway	WP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS	FASN CYP51A1 FADS2	6.10e-04	47	50	3	M39853
Pathway	REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS	FASN ACACB ENPP2 LRP2 PC	6.59e-04	198	50	5	M18311
Pathway	REACTOME_BIOTIN_TRANSPORT_AND_METABOLISM	ACACB PC	6.64e-04	11	50	2	M27086
Pathway	REACTOME_BIOTIN_TRANSPORT_AND_METABOLISM	ACACB PC	6.64e-04	11	50	2	MM14764
Pathway	WP_ELONGATION_OF_VERY_LONG_CHAIN_FATTY_ACIDS	FASN FADS2	7.95e-04	12	50	2	MM17077
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP2S1 CYP2W1	7.95e-04	12	50	2	M27128
Pathway	WP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS	FASN CYP51A1 FADS2	8.21e-04	52	50	3	MM15920
Pathway	REACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS	FASN ACACB LRP2 PC	8.50e-04	120	50	4	MM14771
Pathway	REACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF	FASN ACACB CYP51A1	9.67e-04	55	50	3	M27001
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	FASN FADS2	1.09e-03	14	50	2	M39780
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	FASN FADS2	1.09e-03	14	50	2	MM15840
Pathway	WP_OXIDATION_BY_CYTOCHROME_P450	CYP51A1 CYP2S1 CYP2W1	1.37e-03	62	50	3	M39653
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP51A1 CYP2S1 CYP2W1	1.50e-03	64	50	3	M5650
Pathway	REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS	FPGT ST8SIA3 GFPT1	1.50e-03	64	50	3	M892
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP51A1 CYP2S1 CYP2W1	1.64e-03	66	50	3	MM14839
Pubmed	Quantitative study of the interactome of PKCζ involved in the EGF-induced tumor cell chemotaxis.	DOCK4 FASN ELMO2 KDR EIF3I HSPA4	8.81e-07	184	61	6	23402259
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	RANBP2 VPS18 FASN MAGOH WFS1 SAP18 NAT10 MAGOHB EIF3I HSPA4 HNRNPA2B1 GFPT1	1.47e-06	1247	61	12	27684187
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	RANBP2 FASN ACACB SAP18 NAT10 MAGOHB FADS2 EIF3I RREB1 PC HSPA4 HNRNPA2B1	2.61e-06	1318	61	12	30463901
Pubmed	Deficiency of alkaline SMase enhances dextran sulfate sodium-induced colitis in mice with upregulation of autotaxin.	ENPP7 ENPP2	3.03e-06	2	61	2	30087205
Pubmed	Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay.	MAGOH MAGOHB	3.03e-06	2	61	2	23917022
Pubmed	C13orf31 (FAMIN) is a central regulator of immunometabolic function.	FASN LACC1	3.03e-06	2	61	2	27478939
Pubmed	CYP2S1 and CYP2W1 expression is associated with patient survival in breast cancer.	CYP2S1 CYP2W1	3.03e-06	2	61	2	35902379
Pubmed	Binding of USP4 to cortactin enhances cell migration in HCT116 human colon cancer cells.	RANBP2 FASN EIF3I PC HNRNPA2B1	4.39e-06	137	61	5	37039823
Pubmed	BGL3 lncRNA mediates retention of the BRCA1/BARD1 complex at DNA damage sites.	FASN PC HSPA4 HNRNPA2B1	8.51e-06	73	61	4	32347575
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZNF462 RANBP2 FASN ACACB LRP2 RREB1 PC	8.59e-06	418	61	7	34709266
Pubmed	Overexpression of Fatty Acid Synthase Upregulates Glutamine-Fructose-6-Phosphate Transaminase 1 and O-Linked N-Acetylglucosamine Transferase to Increase O-GlcNAc Protein Glycosylation and Promote Colorectal Cancer Growth.	FASN GFPT1	9.07e-06	3	61	2	38732103
Pubmed	Autotaxin and vascular endothelial growth factor receptor-2 and -3 are related to vascular development during the progression of chronic viral hepatitis C.	ENPP2 KDR	9.07e-06	3	61	2	30456868
Pubmed	eIF3i activity is critical for endothelial cells in tumor induced angiogenesis through regulating VEGFR and ERK translation.	KDR EIF3I	9.07e-06	3	61	2	28193911
Pubmed	Assembly, disassembly and recycling: the dynamics of exon junction complexes.	MAGOH MAGOHB	9.07e-06	3	61	2	21289489
Pubmed	MAGOH and MAGOHB Knockdown in Melanoma Cells Decreases Nonsense-Mediated Decay Activity and Promotes Apoptosis via Upregulation of GADD45A.	MAGOH MAGOHB	9.07e-06	3	61	2	36497117
Pubmed	Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate.	FASN ACACB	9.07e-06	3	61	2	18455495
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	RANBP2 FASN SAP18 NAT10 GBE1 XRCC1 EIF3I KDM6A GFPT1 NSD3	9.94e-06	1014	61	10	32416067
Pubmed	Visceral endoderm expression of Yin-Yang1 (YY1) is required for VEGFA maintenance and yolk sac development.	ENPP2 LRP2 KDR	1.15e-05	25	61	3	23554936
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	ZNF462 RANBP2 FASN MAGOH SAP18 NAT10 CSNK2A3 HNRNPA2B1 NSD3	1.61e-05	847	61	9	35850772
Pubmed	A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.	FASN NEDD4L PC GFPT1	1.79e-05	88	61	4	27182664
Pubmed	Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability.	ACACB PC	1.81e-05	4	61	2	38447582
Pubmed	Class II histone deacetylases play pivotal roles in heat shock protein 90-mediated proteasomal degradation of vascular endothelial growth factor receptors.	KDR HSPA4	1.81e-05	4	61	2	18211808
Pubmed	Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators.	MAGOH SAP18	1.81e-05	4	61	2	22203037
Pubmed	A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair.	KDR HSPA4	1.81e-05	4	61	2	23139789
Pubmed	Long noncoding RNA OVAAL enhances nucleotide synthesis through pyruvate carboxylase to promote 5-fluorouracil resistance in gastric cancer.	PC HSPA4	1.81e-05	4	61	2	35657686
Pubmed	Quantitative interaction proteomics of neurodegenerative disease proteins.	FASN CYP51A1 FADS2 EIF3I HSPA4 HNRNPA2B1	2.21e-05	323	61	6	25959826
Pubmed	Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program.	FASN ACACB	3.02e-05	5	61	2	37163372
Pubmed	The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.	MAGOH MAGOHB	3.02e-05	5	61	2	11532962
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	RANBP2 FASN SAP18 NAT10 CYP2S1 EIF3I HNRNPA2B1 GFPT1	3.32e-05	711	61	8	33022573
Pubmed	Human transcription factor protein interaction networks.	ZNF462 MAGOH ACACB DNAH10 NAT10 LRP2 XRCC1 EIF3I RREB1 KDM6A HSPA4	3.42e-05	1429	61	11	35140242
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	ENPP7 MAGOH ATP6V0A1 DNAH10 LRP2 MAGOHB GFPT1 NSD3	4.00e-05	730	61	8	34857952
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	RANBP2 NAT10 XRCC1 EIF3I RREB1 PC HNRNPA2B1 NSD3 HDGFL3	4.09e-05	954	61	9	36373674
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ZNF462 RANBP2 FASN MAN1A2 WFS1 CYP51A1 TMX4 FADS2 EIF3I HNRNPA2B1	4.28e-05	1203	61	10	29180619
Pubmed	Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism.	DOCK4 ELMO2	4.52e-05	6	61	2	20679435
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	RANBP2 FASN ACACB SAP18 PC NSD3	4.72e-05	370	61	6	22922362
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DNAJB13 MAGOH ATP6V0A1 WFS1 SAP18 NAT10 CYP51A1 TMX4 FADS2 HSPA4 HNRNPA2B1	4.91e-05	1487	61	11	33957083
Pubmed	Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins.	NAT10 MCF2L2 HSPA4	5.22e-05	41	61	3	19343720
Pubmed	Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.	FASN ACACB EIF3I PC HSPA4 HNRNPA2B1	5.24e-05	377	61	6	25147182
Pubmed	The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.	RANBP2 FASN NAT10 PC HSPA4	6.14e-05	237	61	5	29564676
Pubmed	An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.	FASN SAP18 MAGOHB CYP2S1 EIF3I HSPA4	6.96e-05	397	61	6	21319273
Pubmed	Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II.	RANBP2 ACACB PC HSPA4 HNRNPA2B1	7.05e-05	244	61	5	30349055
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	RANBP2 SAP18 NAT10 MAGOHB XRCC1 RREB1 PC KDM6A HNRNPA2B1 NSD3	7.87e-05	1294	61	10	30804502
Pubmed	Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid.	ENPP2 KDR	8.42e-05	8	61	2	16829511
Pubmed	Pharmacogenetic interaction analysis for the efficacy of systemic treatment in metastatic colorectal cancer.	KDR XRCC1	8.42e-05	8	61	2	21048041
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	ZNF462 RANBP2 SAP18 NAT10 MAGOHB HNRNPA2B1	8.42e-05	411	61	6	35182466
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	ZNF462 RANBP2 MAGOH NEDD4L SAP18 NAT10 CYP51A1 HNRNPA2B1 NSD3	1.07e-04	1082	61	9	38697112
Pubmed	A new XRCC1-containing complex and its role in cellular survival of methyl methanesulfonate treatment.	XRCC1 HSPA4	1.08e-04	9	61	2	15367657
Pubmed	Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD.	ADAMTS3 KDR	1.08e-04	9	61	2	27159393
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	DOCK4 RANBP2 ACACB ELMO2 SAP18 LRP2 PC GFPT1	1.18e-04	853	61	8	28718761
Pubmed	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	FASN SAP18 XRCC1 EIF3I HSPA4 HNRNPA2B1	1.24e-04	441	61	6	31239290
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	RANBP2 FASN MAGOHB GBE1 XRCC1 RREB1 KDM6A HSPA4 HNRNPA2B1	1.24e-04	1103	61	9	34189442
Pubmed	Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.	RANBP2 FASN ATP6V0A1 WFS1 CYP51A1 TMX4 EIF3I HSPA4	1.24e-04	859	61	8	31536960
Pubmed	Identification of translationally controlled tumor protein in promotion of DNA homologous recombination repair in cancer cells by affinity proteomics.	RANBP2 CYP51A1 EIF3I HDGFL3	1.26e-04	145	61	4	28846114
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	FASN NEDD4L WFS1 SAP18 NAT10 MAGOHB FADS2 PC HNRNPA2B1 GFPT1	1.27e-04	1371	61	10	36244648
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	RANBP2 FASN NAT10 MAGOHB EIF3I PC HSPA4	1.29e-04	641	61	7	36057605
Pubmed	Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma.	KDM6A NSD3	1.35e-04	10	61	2	22421440
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	RANBP2 FASN SAP18 NAT10 PC HNRNPA2B1 GFPT1	1.47e-04	655	61	7	35819319
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	DOCK4 RANBP2 NEDD4L ACACB WFS1 TMX4 FADS2 EIF3I PC	1.58e-04	1139	61	9	36417873
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	RANBP2 FASN NEDD4L MAGOHB EIF3I TRIM47 PC HSPA4 HNRNPA2B1 GFPT1	1.64e-04	1415	61	10	28515276
Pubmed	Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.	DOCK4 SAP18 NAT10 HSPA4	1.67e-04	156	61	4	22952844
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	RANBP2 FASN ATP6V0A1 DNAH10 NAT10 EIF3I PC HSPA4 HNRNPA2B1 GFPT1	1.73e-04	1425	61	10	30948266
Pubmed	Cell cycle-dependent palmitoylation of protocadherin 7 by ZDHHC5 promotes successful cytokinesis.	FASN PC HSPA4 HNRNPA2B1	1.79e-04	159	61	4	36762613
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	RANBP2 FASN ACACB NAT10 EIF3I PC HSPA4 GFPT1	2.20e-04	934	61	8	33916271
Pubmed	The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.	DOCK4 FASN MAGOH SAP18	2.26e-04	169	61	4	23084401
Pubmed	The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family.	DOCK4 ELMO2	2.33e-04	13	61	2	21930703
Pubmed	Maternal Calorie Restriction Induces a Transcriptional Cytoprotective Response in Embryonic Liver Partially Dependent on Nrf2.	FASN ACACB	2.33e-04	13	61	2	36421460
Pubmed	A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa.	LRP2 NTNG1	2.33e-04	13	61	2	21079607
Pubmed	Myc-dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor-2.	FASN KDR	2.33e-04	13	61	2	31545012
Pubmed	Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.	CYP51A1 CYP2S1 CYP2W1	2.58e-04	70	61	3	15128046
Pubmed	A PWWP Domain of Histone-Lysine N-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin.	NSD3 HDGFL3	2.72e-04	14	61	2	26912663
Pubmed	Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3.	ZNF462 ATP6V0A1 XRCC1 HSPA4 HNRNPA2B1	2.95e-04	332	61	5	30595499
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	RANBP2 FASN NAT10 RREB1 HNRNPA2B1	2.95e-04	332	61	5	32786267
Pubmed	Regulation of the Mdm2-p53 pathway by the ubiquitin E3 ligase MARCH7.	RANBP2 TRIM47	3.13e-04	15	61	2	29295817
Pubmed	Deficiency of autotaxin/lysophospholipase D results in head cavity formation in mouse embryos through the LPA receptor-Rho-ROCK pathway.	ENPP2 KDR	3.13e-04	15	61	2	20692235
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	RANBP2 FASN NAT10 CYP51A1 FADS2 PC HSPA4 HNRNPA2B1	3.22e-04	989	61	8	36424410
Pubmed	The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos.	KDR RREB1	3.57e-04	16	61	2	33929320
Pubmed	Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.	VPS18 DNAH10 SLC15A5 RREB1	3.75e-04	193	61	4	22589738
Pubmed	Interaction network of human early embryonic transcription factors.	ZNF462 RANBP2 ACACB RREB1 KDM6A	3.81e-04	351	61	5	38297188
Pubmed	Conserved and Divergent Features of Human and Mouse Kidney Organogenesis.	LRP2 KDR	4.05e-04	17	61	2	29449453
Pubmed	ATX expression and LPA signalling are vital for the development of the nervous system.	ENPP2 KDR	4.55e-04	18	61	2	20079728
Pubmed	The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.	RANBP2 NAT10 HNRNPA2B1	4.74e-04	86	61	3	37253089
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	RANBP2 VPS18 FASN SAP18 MAGOHB EIF3I PC HSPA4 HNRNPA2B1	5.06e-04	1335	61	9	29229926
Pubmed	Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis.	ATP6V0A1 LRP2	5.08e-04	19	61	2	16177003
Pubmed	BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing.	SAP18 MAGOHB	5.08e-04	19	61	2	25263594
Pubmed	Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.	DOCK4 FASN ELMO2 HSPA4 HNRNPA2B1	5.66e-04	383	61	5	29331416
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	RANBP2 FASN CYP51A1 FADS2 EIF3I PC HSPA4 HNRNPA2B1 GFPT1	6.00e-04	1367	61	9	32687490
Pubmed	UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.	RANBP2 GFPT1	6.22e-04	21	61	2	37422473
Pubmed	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.	RANBP2 ATP6V0A1 NEDD4L CYP51A1 PC	6.28e-04	392	61	5	33144569
Pubmed	FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis.	CYP51A1 FADS2 HSPA4 HNRNPA2B1	6.56e-04	224	61	4	28443643
Pubmed	The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.	TSNAXIP1 ENPP2 HSPA4 HNRNPA2B1	6.67e-04	225	61	4	25277244
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	RANBP2 FASN MAGOH NAT10 MAGOHB HNRNPA2B1 GFPT1	6.76e-04	844	61	7	25963833
Pubmed	Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).	FASN ACACB	6.83e-04	22	61	2	20965718
Pubmed	The imprinted Phlda2 gene regulates extraembryonic energy stores.	GBE1 KDR	6.83e-04	22	61	2	19884348
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZNF462 NAT10 XRCC1 RREB1 NSD3 HDGFL3	6.84e-04	608	61	6	36089195
Pubmed	Klf14 is an imprinted transcription factor that regulates placental growth.	ENPP2 KDR	7.48e-04	23	61	2	31675530
Pubmed	ATP-citrate lyase deficiency in the mouse.	FASN ACACB	7.48e-04	23	61	2	14662765
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	RANBP2 FASN ELMO2 CYP51A1 EIF3I	7.52e-04	408	61	5	33766124
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DOCK4 NEDD4L ELMO2 EIF3I PC CDC14A NSD3	7.59e-04	861	61	7	36931259
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	FASN ATP6V0A1 WFS1 PC KDM6A HNRNPA2B1	7.64e-04	621	61	6	22794259
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	ACACB NAT10 KDR PC	7.72e-04	234	61	4	36243803
Interaction	SLC12A1 interactions	FASN NEDD4L HNRNPA2B1	1.25e-06	8	58	3	int:SLC12A1
Interaction	GATA4 interactions	ZNF462 DNAH10 SAP18 NAT10 MAGOHB XRCC1 KDM6A HNRNPA2B1	2.20e-05	411	58	8	int:GATA4
Cytoband	1p13	MAN1A2 PHTF1	2.33e-04	17	61	2	1p13
Coexpression	GSE6674_ANTI_IGM_VS_PL2_3_STIM_BCELL_DN	BDP1 RANBP2 FASN ELMO2 HSPA4 GFPT1	6.32e-06	199	60	6	M6932
Coexpression	YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_7	MAGOH RREB1 HSPA4 HNRNPA2B1	2.40e-05	73	60	4	M17481
Coexpression	FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN	ENPP2 LRP2 GBE1 KDR FPGT EIF3I PC HSPA4	3.64e-05	553	60	8	M1475
CoexpressionAtlas	kidney_adult_RenMedVasc_Tie2_k-means-cluster#4_top-relative-expression-ranked_500	DOCK4 NOD1 CDC14A	4.72e-05	25	60	3	gudmap_kidney_adult_RenMedVasc_Tie2_k4_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_k-means-cluster#5_top-relative-expression-ranked_1000	ZNF627 MAN1A2 ADAMTS3 ENPP2 CYP51A1 RREB1 KDM6A HDGFL3	5.70e-05	478	60	8	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_1000_k5
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_1000	ZNF462 NEDD4L ACACB OSGEPL1 TMX4 LRP2 GBE1 ST8SIA3 HSPA4 HNRNPA2B1 PHTF1	8.67e-05	986	60	11	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_top-relative-expression-ranked_1000	ZNF462 ZNF627 MAN1A2 ADAMTS3 ENPP2 CYP51A1 NTNG1 RREB1 GFPT1 HDGFL3	1.07e-04	836	60	10	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_1000
CoexpressionAtlas	facebase_RNAseq_e10.5_MaxArch_2500_K3	ZNF462 MAN1A2 NEDD4L OSGEPL1 ENPP2 NAT10 FPGT KDM6A CDC14A HSPA4 NSD3 HDGFL3	1.68e-04	1252	60	12	facebase_RNAseq_e10.5_MaxArch_2500_K3
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3	ZNF462 BDP1 FASN ATP6V0A1 NEDD4L OSGEPL1 NAT10 CYP51A1 CDC14A HSPA4 HNRNPA2B1 HDGFL3	1.74e-04	1257	60	12	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500	ZNF462 BDP1 FASN ATP6V0A1 NEDD4L KCNC1 OSGEPL1 NAT10 CYP51A1 CDC14A HSPA4 HNRNPA2B1 HDGFL3	1.78e-04	1459	60	13	facebase_RNAseq_e10.5_Emin_LatNas_2500
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FASN ACACB CYP51A1 GBE1 PC	3.15e-06	165	61	5	d449a568664a81d9b5538e8f409301448a32ac37
ToppCell	5'-Adult-Distal_Rectal-Epithelial-goblet-BEST2+_Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FASN NEDD4L SLC28A3 GFPT1 CYP2W1	4.19e-06	175	61	5	019ea30ac55748463d7917abf3d3f0e804189bfd
ToppCell	5'-Adult-Distal_Rectal-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FASN NEDD4L SLC28A3 GFPT1 CYP2W1	4.56e-06	178	61	5	9099b47e0756d6a1b7ba1c6aa7b47c5425f649e0
ToppCell	droplet-Pancreas-Endocrine-21m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WFS1 ENPP2 PC HNRNPA2B1 GFPT1	6.92e-06	194	61	5	3a3ecedcdc7691cf21775818b598208fcb980c29
ToppCell	TCGA-Mesothelium-Primary_Tumor-Mesothelioma-Epitheliod-2\|TCGA-Mesothelium / Sample_Type by Project: Shred V9	DOCK4 ACACB SLC28A3 FPGT	6.86e-05	160	61	4	d288b0a315f6adc0be4bdc89fa67bf93679a743f
ToppCell	LV-11._Adipocyte\|World / Chamber and Cluster_Paper	FASN ACACB ENPP2 PC	7.92e-05	166	61	4	7e5852891714465c6228c9f955fd511ec79d0e02
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NOD1 ENPP2 MCF2L2 KDR	9.50e-05	174	61	4	3d4c05ea5719ca65e85d1f15198453034791087c
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS3 NTNG1 GBE1 CDC14A	9.92e-05	176	61	4	03d194c9814e12802cd932afade69e868814cb78
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	RANBP2 KDM6A CDC14A HNRNPA2B1	1.11e-04	181	61	4	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENPP2 FADS2 GBE1 PC	1.13e-04	182	61	4	770ce9f3f4538d0181a0181543841bc964c68274
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENPP2 FADS2 GBE1 PC	1.13e-04	182	61	4	77ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENPP2 FADS2 GBE1 PC	1.13e-04	182	61	4	4921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 ENPP2 KDR GASK1B	1.15e-04	183	61	4	dc19857b66dcadbf7c87de91f7b1f4e8ef2857ed
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 ENPP2 KDR GASK1B	1.15e-04	183	61	4	4759560e5b4f4e5a00e5f933e3451a27c7c4aefe
ToppCell	normal_Lung-Endothelial_cells-Tumor_ECs\|normal_Lung / Location, Cell class and cell subclass	ENPP2 KDR TRIM47 GASK1B	1.18e-04	184	61	4	7ee98acda030366ac6cf3890a6d93fd0426712ed
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ATP6V0A1 ENPP2 MCF2L2 GFPT1	1.20e-04	185	61	4	e06a784a297f357f3f8e761c24fa70722048ab42
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH10 SLC28A3 CYP2S1 RREB1	1.20e-04	185	61	4	05bc89a566b0db90ae06506e067190a4739a0974
ToppCell	P28-Epithelial-airway_epithelial_cell-club_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DNAJB13 TSNAXIP1 DNAH10 CYP2S1	1.23e-04	186	61	4	a26811481668fa25c48a064a56c198685693ad8d
ToppCell	P28-Epithelial-airway_epithelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DNAJB13 TSNAXIP1 DNAH10 CYP2S1	1.23e-04	186	61	4	df80f101954b8ec6ccdb03e702de22e70b65181f
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF462 NEDD4L NTNG1 HSPA4	1.25e-04	187	61	4	b426a67b5669019115b58295ce7d304beeb75825
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	RANBP2 KDM6A CDC14A HNRNPA2B1	1.28e-04	188	61	4	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF462 DOCK4 TRIM47 CDC14A	1.31e-04	189	61	4	8e583ec4df0f5b79ce5211cc99ecd8616d180bde
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ENPP2 LRP2 RREB1 CDC14A	1.31e-04	189	61	4	42ab4cc5fbf8580841f31889446fe4499df1a464
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF462 DOCK4 TRIM47 CDC14A	1.31e-04	189	61	4	fb2253b8463d08b3d28e952a31a23dea2c2d986b
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF462 NEDD4L NTNG1 HSPA4	1.33e-04	190	61	4	7179f980f895d3e5b839b5ae26b5c991787bfe3a
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAJB13 TSNAXIP1 DNAH10 CYP2S1	1.36e-04	191	61	4	1e21de183a9c09cfb6aad3f9b948087fb6bad061
ToppCell	E18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAJB13 TSNAXIP1 DNAH10 CYP2S1	1.36e-04	191	61	4	e8d56e9f43943e9cc4dce83f2c234f19c2dd487d
ToppCell	PND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAJB13 TSNAXIP1 DNAH10 CYP2S1	1.36e-04	191	61	4	96483adb97c81208aa513782550acd8a08b63866
ToppCell	E18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAJB13 TSNAXIP1 DNAH10 CYP2S1	1.36e-04	191	61	4	52e8d7dfaf1ebb6df8bf3a1f4546af59faa67657
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	BDP1 ENPP2 KDM6A HSPA4	1.39e-04	192	61	4	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	RANBP2 KDM6A CDC14A HNRNPA2B1	1.39e-04	192	61	4	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WFS1 ENPP2 PC GFPT1	1.41e-04	193	61	4	fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WFS1 ENPP2 PC GFPT1	1.41e-04	193	61	4	471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCell	CTRL-Myeloid-Monocyte_Macrophage\|Myeloid / Disease state, Lineage and Cell class	DOCK4 NEDD4L CYP2S1 GASK1B	1.44e-04	194	61	4	73459ee062ae1f1a3bb9719dc0b89aae10600e22
ToppCell	droplet-Limb_Muscle-MUSCLE\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BDP1 RANBP2 KDR NSD3	1.44e-04	194	61	4	e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WFS1 ENPP2 PC GFPT1	1.44e-04	194	61	4	0b023de48ed8a550d169bbe954881eb04bf4f981
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FASN CYP51A1 LRP2 FADS2	1.47e-04	195	61	4	d9694db6bf239636d1335016878c98f6ee2eb0eb
ToppCell	Parenchymal-NucSeq-Stromal-Mesofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS3 NPC1L1 NTNG1 SLC28A3	1.47e-04	195	61	4	a52685f76eca269a7d2de8dfc317439483e233fa
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WFS1 ENPP2 PC GFPT1	1.47e-04	195	61	4	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WFS1 ENPP2 PC GFPT1	1.47e-04	195	61	4	58b769da05a8f6b05aeb08d4f8b112941087ad00
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 ENPP2 GASK1B HDGFL3	1.47e-04	195	61	4	77e47d2e8b3eb7f7c9620369ccaf87581f923bdb
ToppCell	Parenchymal-NucSeq-Stromal-Mesofibroblastic-Mesothelia\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS3 NPC1L1 NTNG1 SLC28A3	1.47e-04	195	61	4	224deeba2f60def6543a55bb4f5ee6c7fdab3f02
ToppCell	background-Endothelial_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	ZNF462 DOCK4 NOD1 KDR	1.50e-04	196	61	4	e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCell	remission-CD4+_Tcm\|remission / disease stage, cell group and cell class	ZNF462 TRIM47 CDC14A NSD3	1.50e-04	196	61	4	db7a9669ae35e2c6b465941afef9f7a6b1e7190e
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 ENPP2 KDR GASK1B	1.53e-04	197	61	4	c10dd1aaec01fb662eac83dfde90e3e426665d65
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 ENPP2 KDR GASK1B	1.53e-04	197	61	4	2844dbcd0a673ed81c99920aa45858651a00736d
ToppCell	IPF-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	DOCK4 ADAMTS3 ENPP2 GASK1B	1.56e-04	198	61	4	b8bd1ba268480f54451648e01631b615a3401144
ToppCell	Influenza-Influenza_Severe-Lymphocyte-T/NK-Treg\|Influenza_Severe / Disease, condition lineage and cell class	NAT10 MCF2L2 DSEL CDC14A	1.56e-04	198	61	4	e377fa0215f338f86ee2903ce3fa57cea805a630
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DOCK4 ADAMTS3 NTNG1 FADS2	1.59e-04	199	61	4	30d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FASN CYP51A1 LRP2 FADS2	1.59e-04	199	61	4	2dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCell	3'_v3-GI_small-bowel-Myeloid_Mac\|GI_small-bowel / Manually curated celltypes from each tissue	DOCK4 LACC1 ENPP2 GASK1B	1.59e-04	199	61	4	8990a3d69e24cb3aaba9d6def3d0be9ee973436d
ToppCell	3'_v3-GI_small-bowel-Myeloid_Mac-Intestinal_macrophages\|GI_small-bowel / Manually curated celltypes from each tissue	DOCK4 LACC1 ENPP2 GASK1B	1.59e-04	199	61	4	96070b5ffcbab4952970f43b536969ddd2ca5d14
ToppCell	5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ENPP2 KDR GASK1B HDGFL3	1.59e-04	199	61	4	258d59cf811bf1668ffbb5f18f961021f660de62
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DOCK4 ADAMTS3 NTNG1 FADS2	1.62e-04	200	61	4	9b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 ENPP2 KDR GASK1B	1.62e-04	200	61	4	2e47888e041ec3d265425d1df97b6665c6da889c
ToppCell	Sigmoid-Macrophage-Macrophage\|Sigmoid / Region, Cell class and subclass	DOCK4 LACC1 CYP2S1 GASK1B	1.62e-04	200	61	4	9ee3a799de7bade1bfe94b6827461633f02bc1dc
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 ENPP2 KDR GASK1B	1.62e-04	200	61	4	50fa0f8a3e490d5941b34e66a10158eba6c909d4
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ENPP7 NEDD4L CYP2S1 CYP2W1	1.62e-04	200	61	4	3e13c9a4ba99a7dfbf738b0fb63fb54b4dee5897
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 ENPP2 KDR GASK1B	1.62e-04	200	61	4	7a69ad5b6c84f1aebacea5cacb9bc5c63dfd1dac
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ENPP7 NEDD4L CYP2S1 CYP2W1	1.62e-04	200	61	4	73bfdf068a8ecbefc1e6afe9686df73658ee042f
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	DOCK4 ADAMTS3 NTNG1 FADS2	1.62e-04	200	61	4	bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 ENPP2 KDR GASK1B	1.62e-04	200	61	4	dba96cda5f3b780a3d4171b61bc8aaddc1f5d466
ToppCell	Sigmoid-(6)_Macrophage-(60)_Macrophage\|Sigmoid / shred on region, Cell_type, and subtype	DOCK4 LACC1 CYP2S1 GASK1B	1.62e-04	200	61	4	ad84a83a5a1893f7b053d39eddeca851463a8ff0
Drug	Fatty Acids, Essential	FASN ACACB NPC1L1 CYP51A1 FADS2	4.42e-07	59	59	5	ctd:D005228
Disease	Colorectal Carcinoma	VPS18 MCF2L2 LRP2 NTNG1 FADS2 KDR XRCC1 DSEL KDM6A CDC14A	1.02e-06	702	58	10	C0009402
Disease	Manic	NTNG1 FADS2 PC HSPA4	1.72e-05	78	58	4	C0338831
Disease	alkaline phosphatase measurement	MAN1A2 NEDD4L ACACB NTNG1 FADS2 RREB1 ST8SIA3 HSPA4 PHTF1 CYP2W1	2.58e-05	1015	58	10	EFO_0004533
Disease	muscular disease (implicated_via_orthology)	FASN ACACB	3.78e-05	5	58	2	DOID:0080000 (implicated_via_orthology)
Disease	very low density lipoprotein cholesterol measurement, phospholipid measurement	TSNAXIP1 ACACB DNAH10 NPC1L1 FADS2	8.83e-05	229	58	5	EFO_0004639, EFO_0008317
Disease	very low density lipoprotein cholesterol measurement	ACACB DNAH10 NPC1L1 FADS2 CYP2W1	1.60e-04	260	58	5	EFO_0008317
Disease	very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	ACACB DNAH10 NPC1L1 FADS2 CYP2W1	2.69e-04	291	58	5	EFO_0008317, EFO_0020946
Disease	Birth Weight	ENPP2 XRCC1	3.40e-04	14	58	2	C0005612
Disease	Manic Disorder	NTNG1 FADS2 PC	3.75e-04	71	58	3	C0024713
Disease	stomach cancer (is_implicated_in)	KDR XRCC1 KDM6A	3.90e-04	72	58	3	DOID:10534 (is_implicated_in)
Disease	level of Sterol ester (27:1/18:0) in blood serum	NPC1L1 FADS2	4.48e-04	16	58	2	OBA_2045196
Disease	spinal stenosis	MGAT4D GFPT1	5.07e-04	17	58	2	EFO_0007490
Disease	Depression, Bipolar	NTNG1 FADS2 PC	5.13e-04	79	58	3	C0005587
Disease	Tourette syndrome, schizophrenia	DNAH10 NSD3	5.69e-04	18	58	2	EFO_0004895, MONDO_0005090
Disease	level of Sphingomyelin (d38:2) in blood serum	ADAMTS3 FADS2	6.36e-04	19	58	2	OBA_2045179
Disease	free cholesterol measurement, very low density lipoprotein cholesterol measurement	ACACB DNAH10 NPC1L1 FADS2	8.55e-04	215	58	4	EFO_0008317, EFO_0008591
Disease	Squamous cell carcinoma of esophagus	FASN XRCC1 KDM6A	8.77e-04	95	58	3	C0279626
Disease	very low density lipoprotein cholesterol measurement, lipid measurement	ACACB DNAH10 NPC1L1 FADS2	9.31e-04	220	58	4	EFO_0004529, EFO_0008317
Disease	level of Sphingomyelin (d40:2) in blood serum	ADAMTS3 FADS2	9.36e-04	23	58	2	OBA_2045181
Disease	total cholesterol measurement, very low density lipoprotein cholesterol measurement	ACACB DNAH10 NPC1L1 FADS2	9.95e-04	224	58	4	EFO_0004574, EFO_0008317
Disease	cholesteryl ester measurement, very low density lipoprotein cholesterol measurement	ACACB DNAH10 NPC1L1 FADS2	1.01e-03	225	58	4	EFO_0008317, EFO_0010351
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement	ACACB DNAH10 FADS2	1.20e-03	106	58	3	EFO_0008317, EFO_0008596
Disease	cholesteryl ester measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	ACACB DNAH10 FADS2	1.34e-03	110	58	3	EFO_0008317, EFO_0008596, EFO_0010351
Disease	free cholesterol measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	ACACB DNAH10 FADS2	1.34e-03	110	58	3	EFO_0008317, EFO_0008591, EFO_0008596
Disease	chylomicron measurement, total cholesterol measurement, very low density lipoprotein cholesterol measurement	ACACB DNAH10 FADS2	1.34e-03	110	58	3	EFO_0004574, EFO_0008317, EFO_0008596
Disease	Schizophrenia	DOCK4 ADAMTS3 LRP2 NTNG1 FADS2 KDR XRCC1	1.67e-03	883	58	7	C0036341
Disease	colorectal cancer (is_implicated_in)	KDR XRCC1 KDM6A	1.76e-03	121	58	3	DOID:9256 (is_implicated_in)
Disease	very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	DNAH10 NPC1L1 FADS2 CYP2W1	1.82e-03	264	58	4	EFO_0008317, EFO_0020944
Disease	BMI-adjusted waist circumference, physical activity measurement	ZNF462 DNAH10 ADAMTS3	1.85e-03	123	58	3	EFO_0007789, EFO_0008002
Disease	hyperuricemia	LRP2 RREB1	1.93e-03	33	58	2	EFO_0009104

Protein segments in the cluster

Peptide	Gene	Start	Entry
FQEKRPFDFDFFAHL	BDP1	356	A6H8Y1
PFDFDFFAHLLQKVL	BDP1	361	A6H8Y1
RKGLQHGFFDFETFD	CDC14A	151	Q9UNH5
HFVKREAFLPFSAGR	CYP2W1	416	Q8TAV3
FGFKNSIFHRVIPDF	RANBP2	3106	P49792
TPAFFSFLAHRFGGK	OR52Z1P	236	P0C646
FPKFFTFRARDEFAE	ACACB	1471	O00763
AFRAFHPDLEFVGKF	FADS2	71	O95864
EFLRSFNFHPGTLFL	OSGEPL1	21	Q9H4B0
GFKRFHGRAFSDPFV	HSPA4	66	P34932
KFGHEFLEFEFRPDG	MAGOH	16	P61326
LFGFVRFHEDGARTK	KDM6A	56	O15550
DGRFRKHEAFLPFSL	CYP2S1	421	Q96SQ9
FPEFSGFKHIPDEDF	MCF2L2	66	Q86YR7
TGRLDAGVKFFFHFR	NOD1	221	Q9Y239
FLLRFPHVALFTFDG	NOD1	271	Q9Y239
PDKFFSHVRDGLNFG	LACC1	406	Q8IV20
PFGLAIFGEHLFFTD	LRP2	916	P98164
IFFFGTHETAFLGPK	HDGFL3	46	Q9Y3E1
PDNLHTLFEFVFKGF	NAT10	316	Q9H0A0
TFEDLKFFFPHLRKE	MGAT4D	101	A6NG13
RSEKAFHDQHFGPFF	NPC1L1	391	Q9UHC9
DPRHLVFIDNKGFFD	GASK1B	421	Q6UWH4
FFNITAFGKDFHLRL	ADAMTS3	81	O15072
IFRKEPFFHGRDNYD	CSNK2A3	226	Q8NEV1
FERAGLLFIFNFHPS	GBE1	616	Q04446
RADEFFFDRHPGVFA	KCNC1	51	P48547
FPFFLRNKEFVCRGH	DOCK4	1326	Q8N1I0
PMFFTHDRAFEELFG	ELMO2	436	Q96JJ3
RIGKFEARFFHLAFE	EIF3I	261	Q13347
FLGHAIAFGKSPIEF	CYP51A1	76	Q16850
FGAFFFLPDSSKHKR	MAN1A2	51	O60476
VFHGKPEKVFHEFFG	DNAJB13	91	P59910
AGDLVEFHKFPNFTF	ENPP7	256	Q6UWV6
EFHKFPNFTFRDIEF	ENPP7	261	Q6UWV6
DLSRFDASFFGVHPK	FASN	56	P49327
GDFIFDTFQPFHFFR	DNAH10	4111	Q8IVF4
AGFFEIHRKHFPAVE	SLC15A5	401	A6NIM6
HDRIIFPFGFKFNIA	DSEL	761	Q8IZU8
RLFFPEGGALKEHFS	FAM87A	201	P0C7U9
PVFDATFHLRGREKF	ENPP2	236	Q13822
FEFIRFDKPGFTALA	FPGT	191	O14772
IHFEIKDRFAFFAGP	NTNG1	221	Q9Y2I2
KGKFGHEFLEFEFRP	MAGOHB	16	Q96A72
FAGLFTHRLKPAFFL	TRIM47	601	Q96LD4
LEGAFALVFKSVHFP	GFPT1	181	Q06210
HAGFRSQFALKFLDP	ST8SIA3	56	O43173
HFNFAIVFTDVKRPG	SAP18	86	O00422
DHFFAFKVLPIVVFF	SLC28A3	281	Q9HAS3
GRFFVTTLPAFFHAK	TMX4	101	Q9H1E5
TTLPAFFHAKDGIFR	TMX4	106	Q9H1E5
KKRGFGFVTFDDHDP	HNRNPA2B1	151	P22626
GLAFFPFLHRLFREK	PHTF1	486	Q9UMS5
FHDLGFTDFSCRKFP	RREB1	281	Q92766
FFPDFVTIDHFKEAI	VPS18	791	Q9P253
GIDVFNLFRDFFLKH	ZBED8	216	Q8IZ13
GKAFDFPSSFRIHER	ZNF627	341	Q7L945
LKHDLGDFPVFFFGS	NSD3	991	Q9BZ95
KFLPFSFEHIREGKF	ATP6V0A1	821	Q93050
KHFFLYGEFPGDERR	XRCC1	546	P18887
AFADFKQERPFGHLE	ZNF462	1941	Q96JM2
FVRVHEKPFVAFGSG	KDR	321	P35968
TFPDFFFNFLEHRFG	TSNAXIP1	416	Q2TAA8
VFAHFKDFTATFGPL	PC	1016	P11498
VHGAVKFAFDFFFFP	WFS1	871	O76024
VFHGKLLDGFFIRPF	NEDD4L	721	Q96PU5