Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	DEP	RGS9 PREX1	1.01e-03	22	40	2	PF00610
Domain	DEP	RGS9 PREX1	1.01e-03	22	40	2	PS50186
Domain	DEP	RGS9 PREX1	1.01e-03	22	40	2	SM00049
Domain	DEP_dom	RGS9 PREX1	1.10e-03	23	40	2	IPR000591
Domain	-	FOXR1 RGS9 RFX3 PREX1	1.19e-03	218	40	4	1.10.10.10
Domain	WHTH_DNA-bd_dom	FOXR1 RGS9 RFX3 PREX1	1.74e-03	242	40	4	IPR011991
Domain	MYB_LIKE	BDP1 GON4L	2.99e-03	38	40	2	PS50090
Domain	GDS_CDC24_CS	OBSCN PREX1	3.15e-03	39	40	2	IPR001331
Domain	PDZ	DLG5 PREX1 PRX	3.89e-03	148	40	3	SM00228
Domain	-	DLG5 PREX1 PRX	4.04e-03	150	40	3	2.30.42.10
Domain	PDZ	DLG5 PREX1 PRX	4.11e-03	151	40	3	PS50106
Domain	PDZ	DLG5 PREX1 PRX	4.19e-03	152	40	3	IPR001478
Domain	SET_dom	KMT2C PRDM10	5.13e-03	50	40	2	IPR001214
Domain	SANT	BDP1 GON4L	5.13e-03	50	40	2	SM00717
Domain	SET	KMT2C PRDM10	5.13e-03	50	40	2	PS50280
Domain	SANT/Myb	BDP1 GON4L	5.54e-03	52	40	2	IPR001005
Domain	LRR_6	LRRC42 CARMIL2	6.18e-03	55	40	2	PF13516
Domain	DH_1	OBSCN PREX1	8.04e-03	63	40	2	PS00741
Domain	RhoGEF	OBSCN PREX1	9.32e-03	68	40	2	SM00325
Domain	-	OBSCN PLEKHN1 EPB41L4B PREX1	9.54e-03	391	40	4	2.30.29.30
Domain	Ca/CaM-dep_Ca-dep_prot_Kinase	DCLK3 CAPS2	9.58e-03	69	40	2	IPR020636
Domain	RhoGEF	OBSCN PREX1	9.85e-03	70	40	2	PF00621
Domain	DH_2	OBSCN PREX1	9.85e-03	70	40	2	PS50010
Domain	DH-domain	OBSCN PREX1	1.01e-02	71	40	2	IPR000219
Domain	-	OBSCN PREX1	1.01e-02	71	40	2	1.20.900.10
Pubmed	Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks.	EXO1 ATM	1.36e-06	2	41	2	20019063
Pubmed	Protein-altering germline mutations implicate novel genes related to lung cancer development.	KIAA0930 ATM	1.36e-06	2	41	2	32393777
Pubmed	ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.	EXO1 ATM	4.06e-06	3	41	2	26240375
Pubmed	Region-specific Foxp2 deletions in cortex, striatum or cerebellum cannot explain vocalization deficits observed in spontaneous global knockouts.	RGS9 EMX1	4.06e-06	3	41	2	33303861
Pubmed	Striatal glutamate delta-1 receptor regulates behavioral flexibility and thalamostriatal connectivity.	RGS9 EMX1	4.06e-06	3	41	2	31945419
Pubmed	Differential effects of Foxp2 disruption in distinct motor circuits.	RGS9 EMX1	4.06e-06	3	41	2	30108312
Pubmed	The molecular, temporal and region-specific requirements of the beta isoform of Calcium/Calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion.	RGS9 EMX1	8.12e-06	4	41	2	27244486
Pubmed	The FBXO32/ATR/ATM axis acts as a molecular switch to control the sensitivity of osteosarcoma cells to irradiation through its regulation of EXO1 expression.	EXO1 ATM	8.12e-06	4	41	2	37227155
Pubmed	Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease.	RGS9 EMX1	8.12e-06	4	41	2	24784230
Pubmed	Activating the translational repressor 4E-BP or reducing S6K-GSK3β activity prevents accelerated axon growth induced by hyperactive mTOR in vivo.	EMX1 RPS6KB1	1.35e-05	5	41	2	26220974
Pubmed	The cannabinoid-1 receptor is abundantly expressed in striatal striosomes and striosome-dendron bouquets of the substantia nigra.	RGS9 EMX1	2.03e-05	6	41	2	29466446
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	OBSCN KMT2C ATM EPB41L4B FAM186B GALNT11 HSPH1	2.22e-05	736	41	7	29676528
Pubmed	ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis.	EXO1 ATM	3.78e-05	8	41	2	32051414
Pubmed	Deregulated E2f-2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts.	ATM RBL1	4.86e-05	9	41	2	17923680
Pubmed	Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.	EXO1 LIG1 ATM	5.22e-05	61	41	3	27694478
Pubmed	Network-Based Combinatorial CRISPR-Cas9 Screens Identify Synergistic Modules in Human Cells.	ATM RBL1 NFKB2	5.75e-05	63	41	3	30762338
Pubmed	Genotype-phenotype relationship between DNA repair gene genetic polymorphisms and DNA repair capacity.	LIG1 ATM	6.07e-05	10	41	2	18990028
Pubmed	WT1 regulates expression of DNA repair gene Neil3 during nephrogenesis.	EXO1 LIG1	6.07e-05	10	41	2	36546838
Pubmed	Rheb binds and regulates the mTOR kinase.	ATM RPS6KB1	8.88e-05	12	41	2	15854902
Pubmed	Pocket proteins pRb and p107 are required for cortical lamination independent of apoptosis.	EMX1 RBL1	8.88e-05	12	41	2	24056077
Pubmed	Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.	DLG5 RBL1 NFKB2 HSPH1 SVIL	1.06e-04	401	41	5	25852190
Pubmed	Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability.	ATM EMX1	1.41e-04	15	41	2	26290337
Pubmed	DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis.	ATM EMX1	1.61e-04	16	41	2	28123024
Pubmed	Involvement of Atm and Trp53 in neural cell loss due to Terf2 inactivation during mouse brain development.	ATM EMX1	2.05e-04	18	41	2	28620865
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	OBSCN GON4L PRX	2.34e-04	101	41	3	10997877
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	DLG5 EPB41L4B PRRC2B SVIL	2.60e-04	263	41	4	34702444
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	OBSCN KMT2C KIAA0930 ZNRF3 PREX1 NFKB2 PRRC2B	2.80e-04	1105	41	7	35748872
Pubmed	Snf2h Drives Chromatin Remodeling to Prime Upper Layer Cortical Neuron Development.	ATM EMX1	2.81e-04	21	41	2	31680852
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	OBSCN BDP1 KMT2C ATM HSPH1	2.86e-04	497	41	5	36774506
Pubmed	Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis.	PRDM10 EMX1	3.09e-04	22	41	2	19050759
Pubmed	The DNA sequence and comparative analysis of human chromosome 20.	ZNF133 GDAP1L1 LBP PREX1 RBL1	3.43e-04	517	41	5	11780052
Pubmed	Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors.	ATM EMX1	3.68e-04	24	41	2	22522401
Pubmed	The ciliogenic transcription factor RFX3 regulates early midline distribution of guidepost neurons required for corpus callosum development.	EMX1 RFX3	4.00e-04	25	41	2	22479201
Pubmed	ATR maintains select progenitors during nervous system development.	ATM EMX1	4.00e-04	25	41	2	22266795
Pubmed	Potential protein partners for the N-terminal domain of human topoisomerase I revealed by phage display.	ATM RBL1	7.43e-04	34	41	2	12549820
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	EXO1 LIG1 ATM RBL1	7.69e-04	351	41	4	20453000
Pubmed	A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.	LIG1 ATM	8.80e-04	37	41	2	19116388
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	OBSCN PREX1	9.28e-04	38	41	2	11756498
Pubmed	DNA sequence and analysis of human chromosome 9.	SPATA6L RFX3 SLC24A2 PRRC2B	9.35e-04	370	41	4	15164053
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	GON4L EPB41L4B RBL1 RPS6KB1 PRRC2B	9.65e-04	650	41	5	38777146
Pubmed	Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.	EXO1 LIG1 ATM	1.07e-03	170	41	3	19064572
Interaction	RNF43 interactions	OBSCN DLG5 ZNRF3 EPB41L4B PRRC2B HSPH1 SVIL	1.86e-05	427	40	7	int:RNF43
Cytoband	9p24.2	SPATA6L RFX3	4.26e-05	11	41	2	9p24.2
Cytoband	7q36.1	KMT2C GALNT11	2.02e-03	74	41	2	7q36.1
GeneFamily	PDZ domain containing	DLG5 PREX1 PRX	1.81e-03	152	29	3	1220
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	BDP1 GON4L	3.25e-03	53	29	2	532
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	OBSCN PREX1	5.00e-03	66	29	2	722
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_4\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	EXO1 GON4L AGBL5 PRX	9.04e-06	143	41	4	091708a47ac55c6585923ee30190ff296fa87f6f
ToppCell	LPS_only-Epithelial_airway-Club_cells-Airway\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HS3ST6 ATP10B PLEKHN1 EPB41L4B	1.55e-05	164	41	4	b1243b10591e1e15a94952e39ffbf382eae6aae8
ToppCell	LPS_only-Epithelial_airway\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HS3ST6 ATP10B PLEKHN1 EPB41L4B	1.55e-05	164	41	4	56e6934e6c7503a300d7be06762d45a1d6f1ae0f
ToppCell	LPS_only-Epithelial_airway-Club_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HS3ST6 ATP10B PLEKHN1 EPB41L4B	1.55e-05	164	41	4	c5b2001280a43da855017361a3f6071a0e492848
ToppCell	ASK454-Immune-NK_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	RGS9 ATM CAPS2 PREX1	1.79e-05	170	41	4	84705434234bf2fbb5256bd5a1f6ab54c01c5a51
ToppCell	droplet-Kidney-nan-18m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HS3ST6 ATP10B RGS9 ZNRF3	2.05e-05	176	41	4	533d544852038c0612aacf87f4b1c88ff7aace82
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LIG1 RGS9 RBL1 PRX	2.09e-05	177	41	4	0e74980a7686c31fcf1476b8f19a3392541df240
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DLG5 ATP10B PLEKHN1 HSPH1	2.19e-05	179	41	4	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	10x5'v1-week_17-19-Lymphocytic_NK-T_NK-ILC_precursor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	DLG5 RGS9 PLEKHN1 PREX1	2.19e-05	179	41	4	d18a520568cf4b031972d3dd7d4d4bd073ac1fea
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FOXR1 RGS9 PREX1 PRX	2.24e-05	180	41	4	d8ef44710a77ad0fc03243428e5e1dc4d41200cb
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	BDP1 ZNRF3 RFX3 HSPH1	2.94e-05	193	41	4	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate\|5w / Sample Type, Dataset, Time_group, and Cell type.	DLG5 KIAA0930 GDAP1L1 PRRC2B	3.37e-05	200	41	4	c92e4fc0442404481fcac623d691dae6215b852d
Disease	sweet liking measurement	ATP10B RGS9	2.70e-04	18	40	2	EFO_0010156
Disease	Colorectal cancer, hereditary nonpolyposis, type 1	EXO1 ATM	3.02e-04	19	40	2	C2936783
Disease	Hereditary Non-Polyposis Colon Cancer Type 2	EXO1 ATM	3.02e-04	19	40	2	C1333991
Disease	Adenocarcinoma of large intestine	DCLK3 ATM ZNRF3	3.02e-04	96	40	3	C1319315
Disease	Colorectal Carcinoma	OBSCN EXO1 LIG1 KMT2C GDAP1L1 RPS6KB1	3.42e-04	702	40	6	C0009402
Disease	Granulomatous Slack Skin	ATM NFKB2	4.07e-04	22	40	2	C0376407
Disease	Lymphoma, T-Cell, Cutaneous	ATM NFKB2	4.45e-04	23	40	2	C0079773
Disease	Hereditary Nonpolyposis Colorectal Neoplasms	EXO1 ATM	5.70e-04	26	40	2	C0009405
Disease	Hereditary non-polyposis colorectal cancer syndrome	EXO1 ATM	6.16e-04	27	40	2	C1112155
Disease	Hereditary Nonpolyposis Colorectal Cancer	EXO1 ATM	7.11e-04	29	40	2	C1333990
Disease	right ventricular ejection fraction measurement	OBSCN SVIL	7.61e-04	30	40	2	EFO_0021816
Disease	Bladder Neoplasm	LIG1 KMT2C ATM	9.08e-04	140	40	3	C0005695
Disease	Malignant neoplasm of urinary bladder	LIG1 KMT2C ATM	9.27e-04	141	40	3	C0005684
Disease	Otitis media	ATP10B PRX	1.29e-03	39	40	2	EFO_0004992
Disease	nasopharynx carcinoma (is_marker_for)	KMT2C ATM	1.56e-03	43	40	2	DOID:9261 (is_marker_for)
Disease	Cardiomyopathy, Dilated	CSRNP1 ATM	1.94e-03	48	40	2	C0007193
Disease	Cardiomyopathy, Familial Idiopathic	CSRNP1 ATM	2.11e-03	50	40	2	C1449563
Disease	Liver carcinoma	EXO1 CSRNP1 KMT2C ATM	4.83e-03	507	40	4	C2239176
Disease	cancer (implicated_via_orthology)	LIG1 ATM RBL1	5.71e-03	268	40	3	DOID:162 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
TSTPRPFRFAGKRIF	AGBL5	231	Q8NDL9
APFVRSRFKRPKPNL	BDP1	1431	A6H8Y1
SRSQIQPFFGRKKPL	CAPS2	31	Q9BXY5
LFAFKKPRSTRGPRT	CARMIL2	1101	Q6F5E8
LLKPSTKPRRRYFTG	B3GALT1	191	Q9Y5Z6
FTYRPRTRRVPTKPK	FAM186B	616	Q8IYM0
RKLFGFRLPSKTPSI	ATP10B	971	O94823
RSPRKPFASPSRFIR	RGS9	501	O75916
FRLVKRKPPSFFGAS	GDAP1L1	331	Q96MZ0
LTTKSFRPFVPRLAR	LBP	316	P18428
SPFQRARKKPRSRGK	KMT2C	46	Q8NEZ4
FCGPRSFTPLSILKR	CSRNP1	61	Q96S65
APFSKVLTFLRRGPF	HSPH1	426	Q92598
AFFSPSLKRKVPRNR	KIAA0930	301	Q6ICG6
SPRLRSRLFSKALKG	DCLK3	36	Q9C098
SPKKFYPRFTRGPSR	GALNT11	51	Q8NCW6
LGQKRRRPKSAPSFR	DLG5	1106	Q8TDM6
FSFEPKIRSPRRFIG	RPS6KB1	426	P23443
SSLQKPRPFRLFPKG	LRRC42	36	Q9Y546
VFSKRRIPKRTQFGP	PRDM10	221	Q9NQV6
FSGAPRFLTRPKAFV	OBSCN	6	Q5VST9
PFRTSRKKFLEVPRF	ATM	1766	Q13315
SKRSPPRKRFAFSPS	FOXR1	111	Q6PIV2
APSKFRKPYVRRRPS	GON4L	1106	Q3T8J9
GPFARKPKRIRTAFS	EMX1	186	Q04741
PRRAPKTLSSFFTPR	LIG1	221	P18858
RKPSKRYPSRRHSTF	EPB41L4B	411	Q9H329
SKTPGLPSFRALAFR	HS3ST6	196	Q96QI5
RSRRKSKFSDFPFPT	SPATA6L	241	Q8N4H0
PRRLRASFSRKPSLK	PLEKHN1	11	Q494U1
SRKPRRYFSPGESRK	SVIL	636	O95425
RKPSSRKFFPITFFG	SLC24A2	491	Q9UI40
KKRSFAPSTPLTGRR	RBL1	361	P28749
GRPSFPKAARQFLLK	RFX3	586	P48380
PSVGRSFSIRFGRKP	PREX1	986	Q8TCU6
PPRTRNKFATFLQRK	EXO1	476	Q9UQ84
KSPKFRFPRVSLSPK	PRX	1406	Q9BXM0
GRGLSSRIPPRFAKK	PRRC2B	1591	Q5JSZ5
GRTKKRTLGAFSRPP	ZNF133	156	P52736
FRRPKLSGRSFSKAA	ZNRF3	446	Q9ULT6
QRKRRKALPTFSQPF	NFKB2	336	Q00653