Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesspositive regulation of gluconeogenesis

PPP4R3B HIF1A KAT2A PPP4R3A

5.09e-0632744GO:0045722
DomainPAS_fold_3

HIF1A ARNT2 SIM1 SIM2

2.00e-0623754IPR013655
DomainPAS_3

HIF1A ARNT2 SIM1 SIM2

2.00e-0623754PF08447
DomainPAS-assoc_C

HIF1A ARNT2 SIM1 SIM2

2.40e-0624754IPR000700
DomainPAS

HIF1A ARNT2 SIM1 SIM2

2.85e-0625754PF00989
DomainPAS_fold

HIF1A ARNT2 SIM1 SIM2

2.85e-0625754IPR013767
DomainPAC

HIF1A ARNT2 SIM1 SIM2

3.35e-0626754IPR001610
DomainPAC

HIF1A ARNT2 SIM1 SIM2

3.35e-0626754SM00086
DomainPAC

HIF1A ARNT2 SIM1 SIM2

3.35e-0626754PS50113
DomainPAS

HIF1A ARNT2 SIM1 SIM2

7.92e-0632754SM00091
DomainPAS

HIF1A ARNT2 SIM1 SIM2

1.02e-0534754IPR000014
DomainPAS

HIF1A ARNT2 SIM1 SIM2

1.02e-0534754PS50112
DomainSIM_C

SIM1 SIM2

1.59e-052752IPR010578
DomainSMK-1

PPP4R3B PPP4R3A

1.59e-052752PF04802
DomainSIM_C

SIM1 SIM2

1.59e-052752PF06621
DomainSIM_C

SIM1 SIM2

1.59e-052752PS51302
DomainDUF625

PPP4R3B PPP4R3A

1.59e-052752IPR006887
DomainNuc_translocat

ARNT2 SIM2

4.39e-048752IPR001067
DomainP-loop_NTPase

IFIH1 MDN1 MYO9A ABCC8 KIF21A ASPM DLG2 HFM1 RFC2 ZRANB3 DNAH11

5.44e-048487511IPR027417
DomainHLH

HIF1A ARNT2 SIM1 SIM2

1.04e-03111754PF00010
DomainWH1

PPP4R3B PPP4R3A

1.21e-0313752PS50229
DomainHLH

HIF1A ARNT2 SIM1 SIM2

1.22e-03116754SM00353
DomainBHLH

HIF1A ARNT2 SIM1 SIM2

1.26e-03117754PS50888
DomainbHLH_dom

HIF1A ARNT2 SIM1 SIM2

1.30e-03118754IPR011598
DomainATPase_dyneun-rel_AAA

MDN1 DNAH11

1.40e-0314752IPR011704
DomainAAA_5

MDN1 DNAH11

1.40e-0314752PF07728
Domain-

IFT140 WIPI1 FBXW12 KIF21A SEMA6A PHIP

2.20e-033337562.130.10.10
DomainWD40/YVTN_repeat-like_dom

IFT140 WIPI1 FBXW12 KIF21A SEMA6A PHIP

2.27e-03335756IPR015943
DomainARM-type_fold

PPP4R3B INTS1 ASPM NUP188 MAP3K1 PPP4R3A

2.41e-03339756IPR016024
DomainAAA+_ATPase

MDN1 ABCC8 RFC2 DNAH11

2.70e-03144754IPR003593
DomainAAA

MDN1 ABCC8 RFC2 DNAH11

2.70e-03144754SM00382
DomainPentatricopeptide_repeat

IFT140 XAB2

3.81e-0323752IPR002885
DomainWD40_repeat

IFT140 WIPI1 FBXW12 KIF21A PHIP

4.75e-03272755IPR001680
DomainBromodomain_CS

KAT2A PHIP

4.86e-0326752IPR018359
DomainWD_REPEATS_1

IFT140 WIPI1 FBXW12 KIF21A PHIP

5.21e-03278755PS00678
DomainWD_REPEATS_2

IFT140 WIPI1 FBXW12 KIF21A PHIP

5.29e-03279755PS50082
DomainWD_REPEATS_REGION

IFT140 WIPI1 FBXW12 KIF21A PHIP

5.29e-03279755PS50294
DomainSpectrin_repeat

DRP2 PLEC

6.02e-0329752IPR002017
DomainSpectrin/alpha-actinin

DRP2 PLEC

7.30e-0332752IPR018159
DomainSPEC

DRP2 PLEC

7.30e-0332752SM00150
Pubmed

Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis.

HIF1A ARNT2 SIM1 SIM2

3.32e-1067748927054
Pubmed

Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors.

HIF1A ARNT2 SIM1 SIM2

1.54e-09877411782478
Pubmed

Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2.

ARNT2 SIM1 SIM2

1.04e-08377324814368
Pubmed

Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development.

HIF1A ARNT2 SIM2

2.08e-07677311025203
Pubmed

Separate necdin domains bind ARNT2 and HIF1alpha and repress transcription.

HIF1A ARNT2 SIM1

2.08e-07677317826745
Pubmed

MAGED1 is a novel regulator of a select subset of bHLH PAS transcription factors.

ARNT2 SIM1 SIM2

3.63e-07777327472814
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

CYFIP1 MDN1 SEC24C MYO9A KIF21A POLR2B ASPM EXOC3 PLEC RFC2 PLK1 RPL4 RPL5 PHIP

1.44e-061353771429467282
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

CYFIP1 SEC24C CENPF KIF21A INTS1 PEA15 RPL5 PHIP PPP4R3A

1.60e-0649877936634849
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

MDN1 SEC24C CENPF INTS1 NUP188 PLEC RPL4 RPL5 PHIP XAB2

1.80e-06653771022586326
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

MDN1 SEC24C CENPF POLR2B INTS1 EXOC3 NUP188 PLEC RFC2 RPL5 PHIP XAB2

2.52e-061024771224711643
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PPP4R3B IFT140 VPS13C RALGPS1 KIF21A ADGRB3 SFI1 NUP188 JADE1

2.62e-0652977914621295
Pubmed

Loss of SMEK, a novel, conserved protein, suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects.

PPP4R3B PPP4R3A

4.84e-06277216107728
Pubmed

Replication and extension of association between common genetic variants in SIM1 and human adiposity.

ARNT2 SIM1

4.84e-06277221512513
Pubmed

Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes.

ASPM PLK1

4.84e-06277211283617
Pubmed

Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region.

SIM1 SIM2

4.84e-0627729199934
Pubmed

Single-minded--two genes, three chromosomes.

SIM1 SIM2

4.84e-0627729199929
Pubmed

Overexpression of mSim2 gene in the zona limitans of the diencephalon of segmental trisomy 16 Ts1Cje fetuses, a mouse model for trisomy 21: a novel whole-mount based RNA hybridization study.

SIM1 SIM2

4.84e-06277210837894
Pubmed

Human mutations in integrator complex subunits link transcriptome integrity to brain development.

INTS1 INTS8

4.84e-06277228542170
Pubmed

A novel nuclear localization signal in the human single-minded proteins SIM1 and SIM2.

SIM1 SIM2

4.84e-06277214697214
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

ZBTB44 HIF1A MDN1 CENPF POLR2B INTS1 MCRS1 NUP188 KAT2A RFC2 RPL4 RPL5 XAB2

4.95e-061294771330804502
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

MDN1 SEC24C KIF21A INTS1 SFI1 PLEC RFC2 PLK1 INTS8

5.68e-0658277920467437
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

CYFIP1 MDN1 SEC24C POLR2B NUP188 PLEC RPL4 RPL5 PPP4R3A

1.18e-0563877933239621
Pubmed

The HIF1alpha-inducible pro-cell death gene BNIP3 is a novel target of SIM2s repression through cross-talk on the hypoxia response element.

HIF1A SIM2

1.45e-05377219668230
Pubmed

Physical mapping of the holoprosencephaly critical region in 21q22.3, exclusion of SIM2 as a candidate gene for holoprosencephaly, and mapping of SIM2 to a region of chromosome 21 important for Down syndrome.

SIM1 SIM2

1.45e-0537727485157
Pubmed

cDNA cloning of a murine homologue of Drosophila single-minded, its mRNA expression in mouse development, and chromosome localization.

SIM1 SIM2

1.45e-0537728561800
Pubmed

The lncRNA PVT1 regulates nasopharyngeal carcinoma cell proliferation via activating the KAT2A acetyltransferase and stabilizing HIF-1α.

HIF1A KAT2A

1.45e-05377231320749
Pubmed

Sequential activation of hypoxia-inducible factor 1 and specificity protein 1 is required for hypoxia-induced transcriptional stimulation of Abcc8.

HIF1A ABCC8

1.45e-05377222086197
Pubmed

Cardiac glycosides block cancer growth through HIF-1α- and NF-κB-mediated Plk1.

HIF1A PLK1

1.45e-05377223615397
Pubmed

Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells.

HIF1A ARNT2

1.45e-05377212239177
Pubmed

Characterization of msim, a murine homologue of the Drosophila sim transcription factor.

SIM1 SIM2

1.45e-0537728661115
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

IFIH1 CYFIP1 MDN1 CENPF SPEG POLR2B EXOC3 PLK1

1.46e-0549777836774506
Pubmed

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.

PPP4R3B CYFIP1 MDN1 KIF21A ADGRB3 PLEC RFC2 RPL4 RPL5 PPP4R3A

1.75e-05847771035235311
Pubmed

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.

POLR2B INTS1 INTS8

2.32e-052577334004147
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PPP4R3B VPS13C SPEG INTS1 SEMA6A

2.36e-0515377510718198
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

PPP4R3B ZBTB44 LONRF1 KIF21A NMT2 ADGRB3 DLG2 MCRS1 PLEC SIM2 INTS8 XAB2

2.46e-051285771235914814
Pubmed

Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.

MDN1 ACOX1 PLEC RPL4

2.52e-057677427542412
Pubmed

Sim1 and Sim2 expression during chick and mouse limb development.

SIM1 SIM2

2.89e-05477219123137
Pubmed

Direct type I IFN but not MDA5/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation.

IFIH1 HIF1A

2.89e-05477224409099
Pubmed

[Transcription factors NF-kB, HIF-1, HIF-2, growth factor VEGF, VEGFR2 and carboanhydrase IX mRNA and protein level in the development of kidney cancer metastasis].

HIF1A CA10

2.89e-05477228537244
Pubmed

Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis.

PPP4R3B PPP4R3A

2.89e-05477220876121
Pubmed

Hypoxia-driven proliferation of human pulmonary artery fibroblasts: cross-talk between HIF-1alpha and an autocrine angiotensin system.

HIF1A AGTR1

2.89e-05477215718424
Pubmed

Smek promotes histone deacetylation to suppress transcription of Wnt target gene brachyury in pluripotent embryonic stem cells.

PPP4R3B PPP4R3A

2.89e-05477221423269
Pubmed

Members of the bHLH-PAS family regulate Shh transcription in forebrain regions of the mouse CNS.

SIM1 SIM2

2.89e-05477211023872
Pubmed

Associations between oxytocin-related genes and autistic-like traits.

ARNT2 SIM1

2.89e-05477224635660
Pubmed

PED/PEA-15 regulates glucose-induced insulin secretion by restraining potassium channel expression in pancreatic beta-cells.

ABCC8 PEA15

2.89e-05477217327429
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

PPP4R3B MDN1 SEC24C POLR2B INTS1 PLEC RFC2 PLK1 RPL4 RPL5 PHIP XAB2

3.15e-051318771230463901
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

MDN1 CENPF POLR2B ASPM RFC2 PLK1 RPL4 RPL5 MAP3K1

4.60e-0575977935915203
Pubmed

Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse.

HIF1A ARNT2

4.82e-0557729545558
Pubmed

Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein.

SIM1 SIM2

4.82e-0557729020169
Pubmed

Ribosomal protein L4 is a novel regulator of the MDM2-p53 loop.

RPL4 RPL5

4.82e-05577226908445
Pubmed

Splicing Regulator p54nrb /Non-POU Domain-Containing Octamer-Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box-Dependent Interacting Protein 1 in Hepatocellular Carcinoma.

KIF21A APLP2 PLK1

4.94e-053277331815296
Pubmed

Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation.

HIF1A ARNT2 SIM1 SIM2

6.85e-059877418557763
Pubmed

Olig3 regulates early cerebellar development.

HIF1A ARNT2 SIM1

9.72e-054077333591268
Pubmed

Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression.

ARNT2 SIM2

1.01e-04777214701734
Pubmed

ARNT2 acts as the dimerization partner of SIM1 for the development of the hypothalamus.

ARNT2 SIM1

1.01e-04777210640708
Pubmed

NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.

ARNT2 SIM1

1.01e-04777227782878
Pubmed

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

MDN1 ACOX1 CEP135 NUP188 PLEC PHIP

1.10e-0434077629478914
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

POLR2B INTS1 NUP188 PLK1 INTS8 XAB2

1.12e-0434177632971831
Pubmed

Sim2 contributes to neuroendocrine hormone gene expression in the anterior hypothalamus.

SIM1 SIM2

1.34e-04877214988428
Pubmed

A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.

PPP4R3B PPP4R3A

1.34e-04877218614045
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

SEC24C POLR2B INTS1 APLP2 PLEC SIM1 INTS8 RPL4 RPL5 XAB2

1.35e-041082771038697112
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

HIF1A CYFIP1 POLR2B SEMA6A RPL5 PHIP

1.46e-0435877632460013
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MDN1 LONRF1 RALGPS1 SPEG INTS1 SFI1 NUP188 KAT2A JADE1 PLEC

1.60e-041105771035748872
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

CYFIP1 SEC24C CENPF POLR2B NUP188 RFC2 PLK1 RPL5

1.67e-0470477829955894
Pubmed

Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock.

HIF1A SIM2

1.72e-0497729704006
Pubmed

MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression.

CEP135 PLK1

1.72e-04977223509069
Pubmed

Smek promotes corticogenesis through regulating Mbd3's stability and Mbd3/NuRD complex recruitment to genes associated with neurogenesis.

PPP4R3B PPP4R3A

1.72e-04977228467410
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

HIF1A LMCD1 ARNT2 ZFHX2 MCRS1 KAT2A SIM1 PHIP

1.75e-0470977822988430
Pubmed

Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants.

SIM1 SIM2

2.15e-041077212024028
Pubmed

HIF-dependent hematopoietic factors regulate the development of the embryonic vasculature.

HIF1A ARNT2

2.15e-041077216824955
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

ZBTB44 MDN1 CENPF VPS13C KIF21A INTS1 NUP188 MAGEB6

2.25e-0473677829676528
Pubmed

Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.

POLR2B INTS1 INTS8

2.39e-045477316239144
Pubmed

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.

MDN1 APLP2 RFC2 RPL4 XAB2

2.43e-0425177528077445
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

CYFIP1 POLR2B EXOC3 RFC2 PLK1 XAB2 PPP4R3A

2.46e-0456077735241646
Pubmed

Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt.

ARNT2 SIM1

2.63e-041177211381139
Pubmed

Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression.

POLR2B JADE1 PLK1

2.66e-045677326919559
Pubmed

The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion.

CEP135 SFI1 PLK1

2.66e-045677311076968
Pubmed

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

HIF1A CYFIP1 ARNT2 DLG2 JADE1 PLN

2.73e-0440277624722188
Pubmed

The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.

CEP135 SFI1 PLK1

2.80e-045777316462731
Pubmed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

PPP4R3B MYO9A INTS1 INTS8 RPL4 RPL5 PPP4R3A

2.82e-0457377728330616
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

CYFIP1 MDN1 CENPF VPS13C POLR2B APLP2 NUP188 RFC2 RPL4 RPL5 PHIP

2.93e-041425771130948266
Pubmed

Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.

CEP135 SFI1 PLK1

2.95e-045877312852856
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

ZBTB44 SEC24C POLR2B INTS1 SIM2 PLK1 RPL4

3.13e-0458377729844126
Pubmed

Final stages of cytokinesis and midbody ring formation are controlled by BRUCE.

EXOC3 PLK1

3.15e-041277218329369
Pubmed

Smek1/2 is a nuclear chaperone and cofactor for cleaved Wnt receptor Ryk, regulating cortical neurogenesis.

PPP4R3B PPP4R3A

3.15e-041277229180410
Pubmed

Sim1 and Sim2 are required for the correct targeting of mammillary body axons.

SIM1 SIM2

3.15e-041277216291793
Pubmed

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.

CEP135 SFI1 PLK1

3.42e-04617737790358
Pubmed

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.

VPS13C NUP188 PLEC DNAH11

3.70e-0415277434299191
Pubmed

Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome.

SIM1 SIM2

3.71e-04137728812055
Pubmed

The murine Otp homeobox gene plays an essential role in the specification of neuronal cell lineages in the developing hypothalamus.

SIM1 SIM2

3.71e-041377211071765
Pubmed

Systematic identification of factors for provirus silencing in embryonic stem cells.

CYFIP1 MDN1 SEC24C RFC2

3.80e-0415377426365490
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

PPP4R3B MDN1 POLR2B INTS1 KAT2A PLEC RFC2 XAB2 PPP4R3A

4.02e-04101477932416067
Pubmed

The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.

CYFIP1 CENPF POLR2B KAT2A ZRANB3

4.08e-0428177524163370
Pubmed

Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex.

CEP135 SFI1 PLK1

4.32e-046677312221128
Pubmed

The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts.

INTS1 INTS8

4.33e-041477232697989
Pubmed

Structure of the catalytic core of the Integrator complex.

INTS1 INTS8

4.33e-041477233548203
Pubmed

Diabetic modifier QTLs identified in F2 intercrosses between Akita and A/J mice.

ACOX1 ADCY8

4.33e-041477216964447
Pubmed

INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.

INTS1 INTS8

4.33e-041477232647223
Pubmed

Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.

IFIH1 PLK1

4.33e-041477235733260
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

CYFIP1 MDN1 NMT2 POLR2B INTS1 MCRS1 APLP2 KAT2A RFC2 INTS8 XAB2

4.45e-041497771131527615
GeneFamilyBasic helix-loop-helix proteins

HIF1A ARNT2 SIM1 SIM2

4.00e-04110574420
GeneFamilyX-linked mental retardation|RNA helicases

IFIH1 HFM1

5.27e-04115721168
GeneFamilyIntegrator complex

INTS1 INTS8

9.99e-04155721366
GeneFamilyWD repeat domain containing

IFT140 WIPI1 FBXW12 KIF21A PHIP

1.39e-03262575362
CoexpressionAtlasdev gonad_e13.5_M_GermCell_Oct_top-relative-expression-ranked_1000

DYM MDN1 CENPF MYO9A KIF21A NMT2 POLR2B GML HFM1 NUP188 RPL5 ZRANB3

2.51e-058107512gudmap_dev gonad_e13.5_M_GermCell_Oct_1000
ToppCellfacs-Tongue-nan-3m-Epithelial|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP4R3B HIF1A CYFIP1 POLR2B APLP2 MAP3K1 PPP4R3A

4.86e-081987672f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCellfacs-Tongue-nan-3m|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP4R3B HIF1A CYFIP1 POLR2B APLP2 MAP3K1 PPP4R3A

4.86e-08198767f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCellfacs-Tongue-nan-3m-Epithelial-basal_cell_of_epidermis|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIF1A APLP2 PLEC SIM2 MAP3K1 PPP4R3A

1.14e-0619876622559b161e67b49fe8028bfaf861e069063599f5
ToppCellfacs-Tongue-nan-3m-Epithelial-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIF1A CYFIP1 POLR2B APLP2 MAP3K1 PPP4R3A

1.17e-061997668d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A SIM2 MAP3K1 PNOC DNAH11

1.08e-051707655d5f208682be21ed58320f5fc083a7898f8712da
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RALGPS1 ARNT2 SIM1 SIM2 CA10

1.24e-05175765e5467dacf81f1f913b1719931cf1a7331434a7e7
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPF LMCD1 ASPM CCRL2 PLK1

1.31e-051777652b63f0529ef73e0eede9b7ef1f08b0a0426a9c82
ToppCellCOVID-19-kidney-REN+Pericyte|kidney / Disease (COVID-19 only), tissue and cell type

TMEM74B ABCC8 AGTR1 ADGRB3 IL18R1

1.39e-05179765342c1cc4444f51b8dcb30d3adc98285a25669c6e
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_B-Branch_B2_(eMN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RUNDC3A ABCC8 KIF21A ZFHX2 PNOC

1.42e-05180765368ff7fcfd21ad248f96a83a8b191040ba7d8670
ToppCell10x5'-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-2|bone_marrow / Manually curated celltypes from each tissue

CENPF ASPM APLP2 PLEC PLK1

1.67e-05186765e82d5e7a976b9cfa2b4640c7a7cd1cfea19c4806
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A KIF21A SIM1 SIM2 MAP3K1

1.71e-05187765c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-neuron_precursor|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RUNDC3A KIF21A ADGRB3 ZFHX2 DLG2

1.75e-051887659fd262bbf6cdebfd945e39428a6059726fb55b3a
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RUNDC3A KIF21A ADGRB3 ZFHX2 DLG2

1.75e-05188765459e3fd4335a6f25f982d011b38702f4fcfed1cd
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neuron_precursor-cycling_neuroblast|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CENPF KIF21A ASPM DLG2 PLK1

1.80e-05189765815afad947ed77a8b03724bf78014799fed34f54
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A KIF21A SIM1 SIM2 MAP3K1

1.85e-051907651cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RALGPS1 ARNT2 SIM1 SIM2 CA10

1.85e-05190765b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A KIF21A SIM1 SIM2 MAP3K1

1.85e-0519076559bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCellP07-Mesenchymal-developing_mesenchymal_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CENPF LMCD1 CCRL2 PLK1 ADCY8

1.89e-05191765ddbc5f97f2aef19be4ad93db4139876c939b848e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HIF1A MYO9A ARNT2 SIM2 CA10

1.89e-051917652fa1b9e76a0ed2d2f0de74349e266cf4a5f51aad
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CENPF CEP135 ASPM JADE1 PLK1

1.89e-051917650ba5b112a82e489f5a21966f78a403a7436ce73b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RALGPS1 ARNT2 SIM1 SIM2 CA10

1.94e-05192765562df5e87038c500dd3a003fe5374cb31946b145
ToppCellInfluenza_Severe-T/NK_proliferative|World / Disease group and Cell class

DRP2 CENPF LMCD1 ASPM PLK1

2.09e-051957656f079c2d7d08110a5e1822ea861b8037eb3f62c9
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD4+_T-CD4+_Tcm-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NMT2 KDSR RPL4 RPL5 MAP3K1

2.14e-05196765d4fd5513e98eec092d51199e7f054bc15a5eaa3d
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD4+_T-CD4+_Tcm-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NMT2 KDSR RPL4 RPL5 MAP3K1

2.14e-051967653a08209210e1a8677097a78786e00062c81b1ad2
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD4+_T-CD4+_Tcm|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NMT2 KDSR RPL4 RPL5 MAP3K1

2.14e-05196765fddc3e89e7e6b093563655c2d02e86836cfd6da5
ToppCellCOVID-19_Convalescent-Lymphoid_T/NK-CD4+_Tcm|COVID-19_Convalescent / Disease group, lineage and cell class

NMT2 KDSR RPL4 RPL5 MAP3K1

2.14e-051967658caf4334ae692ce44e8fea5d606416afc5b72c00
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A RALGPS1 ARNT2 SIM1 SIM2

2.14e-051967656ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A RALGPS1 ARNT2 SIM1 SIM2

2.14e-05196765eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell5'-Adult-Appendix|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HIF1A LMCD1 AGTR1 PEA15 RPL5

2.14e-05196765a579211ef14f348d0c5a290553150222dfbf1515
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD4+_T-CD4+_Tcm|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)

NMT2 KDSR RPL4 RPL5 MAP3K1

2.14e-051967657d841113a7161b017a08602d46366ac044271b34
ToppCellHealthy-T/NK_proliferative|World / disease group, cell group and cell class

CENPF LMCD1 ASPM RFC2 PLK1

2.20e-05197765e90be1e7e02f736b6aab14010a912b592d6f1e80
ToppCellLPS_only-Endothelial-Endothelial-FOXM1|LPS_only / Treatment groups by lineage, cell group, cell type

PPP4R3B CENPF NMT2 ASPM PLK1

2.20e-05197765038fd92750257d43d5e980fd06d77742b543f11a
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_B-Branch_B2_(eMN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RUNDC3A ABCC8 KIF21A ZFHX2 DLG2

2.25e-0519876585881637641d8996be2edc65c4bceff0433135e7
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor-cycling_neuroblast|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CENPF KIF21A ASPM DLG2 PLK1

2.25e-051987652ee8ac82ef1b8ebabc8dd824211bbb471f2af8ac
ToppCellsevere-Myeloid-CD14_Monocytes_1|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

CYFIP1 APLP2 PEA15 RPL4 RPL5

2.30e-05199765ce07b7c1edfc6e2136dafcf041361b66a52271d3
ToppCellCOVID-19-COVID-19_Convalescent-Lymphocyte-T/NK-CD4+_Tcm|COVID-19_Convalescent / Disease, condition lineage and cell class

NMT2 KDSR RPL4 RPL5 MAP3K1

2.36e-0520076599c5abfe96d791c60ae6021ab4201851ee4afc47
ToppCellLPS-antiTNF-Unknown-Endothelial-Pericyte_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CENPF AGTR1 ASPM PLK1

7.71e-0513276402491930097b75aaeedab9e8200711b0dc610944
ToppCellFrontal_cortex-Macroglia-POLYDENDROCYTE-P4-Tnr|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CENPF ASPM PLK1 DNAH11

1.02e-041427647bd05d0c0ac2dee0e6cc0f3c531f9154bf300c75
ToppCellFrontal_cortex-Macroglia-POLYDENDROCYTE-P4|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CENPF ASPM PLK1 DNAH11

1.02e-04142764328d08ba2712cd42bb9846ac4d7453ae165b75e2
ToppCellFrontal_cortex-Macroglia-POLYDENDROCYTE-P4-Tnr-Polydendrocyte.Tnr.Dlx1_(Dlx1)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CENPF ASPM PLK1 DNAH11

1.02e-0414276494774d3e598d074f48146b0b094705dc48af5a1f
ToppCellFrontal_cortex-Macroglia-POLYDENDROCYTE-P4-Tnr-Polydendrocyte.Tnr.Dlx1_(Dlx1)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CENPF ASPM PLK1 DNAH11

1.02e-0414276492bf826827b3e3387ad326566556fc90c5c2f4d5
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPF ASPM PLK1 PLN

1.43e-041557648e239470799426ea474a36f57e1b7e0d9365ca5f
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-6|TCGA-Kidney / Sample_Type by Project: Shred V9

DRP2 CENPF ASPM PLK1

1.47e-04156764d249747c7108a0edfc72d24c09b0b0e4ed662b40
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC8 AGTR1 ADGRB3 IL18R1

1.66e-041617641b805f77790aeb8a71b08bfac2fe2eed7343258f
ToppCell356C-Myeloid-Mast_cell|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

NMT2 DLG2 PLN IL18R1

1.78e-04164764b3192c443f4848e6a8afdb89c155f9ec42a154b0
ToppCell356C-Myeloid-Mast_cell-|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

NMT2 DLG2 PLN IL18R1

1.78e-04164764f7288ec4daf494dae770ea6c58bead27660ccae1
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPF ASPM PLK1 IL18R1

1.78e-04164764ae09e5aabd1347b865474255e7411c04f63efb3b
ToppCellBac-SEP-Myeloid-tDC|Bac-SEP / Disease, Lineage and Cell Type

LMCD1 RALGPS1 KAT2A KDSR

1.82e-041657648728f927502e56f2768b4224e9111939d3d7815a
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CENPF ABCC8 AGTR1 IL18R1

1.91e-04167764b4ef07117d14da3d5fbced949e4dfcb01c392295
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CENPF ABCC8 AGTR1 IL18R1

1.91e-0416776494fc7df7ca55cd722a8dbd153201a29891217473
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CENPF ABCC8 AGTR1 IL18R1

1.91e-04167764eff3723fe60755272eca237459165e436e919ece
ToppCellPND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_G2M|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPF ARNT2 ASPM PLK1

1.91e-04167764d21635df8b74189e3309eaf435af381fbe412574
ToppCellControl-T/NK_proliferative|World / Disease group and Cell class

CENPF LMCD1 ASPM PLK1

2.00e-04169764fca735cbb55fce4d32dc6632a39acea1d16b87ab
ToppCelldroplet-Trachea-3m-Hematologic-myeloid-granulocyte-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RUNDC3A CEP135 ASPM PLK1

2.09e-0417176441932c9e70829ee3d55ca5fdb74d290fc8229416
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-epithelial_cell_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CENPF INTS1 ASPM FAM13B

2.18e-04173764a5172dee859bf6c2eed46c48bd64dfef0ff9f28f
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-Lgr5-_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CENPF INTS1 ASPM FAM13B

2.18e-04173764639b5b0b33ce5aa0bc26363c059717012ddc14c0
ToppCell10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor_Myeloid|bone_marrow / Manually curated celltypes from each tissue

CENPF ASPM DLG2 PLK1

2.18e-041737645645a3b1e805c71d5d65fc8e4edc4e13208063fc
ToppCell10x5'-Lung-Myeloid_Dendritic-Cycling_Dendritic|Lung / Manually curated celltypes from each tissue

CENPF LMCD1 ASPM PLK1

2.18e-0417376462e0c18cfed9645e34a9d7029c94a8554f773714
ToppCellBAL-Control-Lymphocyte-T/NK-Other_T|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CENPF LMCD1 ASPM PLK1

2.23e-0417476494575a605c725de83f66a6cf7df9d7bb360ffc56
ToppCellBAL-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CENPF LMCD1 ASPM PLK1

2.23e-0417476440c81ab36d7931e271e20d7d56fed32463c75f41
ToppCellTuft-tuft-4|World / Class top

TMEM74B MDN1 ZFHX2 FAM13B

2.23e-04174764d6f306ebf66061bf9e9742000bfedce12d277452
ToppCellBAL-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CENPF LMCD1 ASPM PLK1

2.23e-04174764b43fb0fbb492c1be6e791a1c4d6c4e5956955ee4
ToppCell10x_5'_v1-Neoplastic-Stem-like-OPC-like|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CENPF ASPM SEMA6A PLK1

2.28e-04175764cc596907ea1a64ab7b5a8c7d4ad12e6ee59bfed9
ToppCell10x_5'_v1-Neoplastic-Stem-like|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CENPF ASPM SEMA6A PLK1

2.28e-04175764a8400e7e47379901dcab5f2e364c3ff17765b4b9
ToppCellBAL-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CENPF LMCD1 ASPM PLK1

2.28e-04175764553e68e8b439a2293efb969e1e2aa017ceb80daf
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_B-plasmablast-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

WIPI1 CENPF LMCD1 PLK1

2.28e-0417576489bf89466191da14896ed8928027f5b911436c22
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DRP2 CENPF ASPM PLK1

2.28e-04175764d43ae33a6256606ce848247cad32d74f21b38988
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DRP2 CENPF ASPM ADCY8

2.28e-0417576415c69dd5635c9251c535f1e22467712e9667ae92
ToppCell367C-Lymphocytic-NK_cells-Proliferating_NK_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CENPF CEP135 ASPM PLK1

2.28e-041757640b1aaa028ba844d4bcb4509fdab8bee648373935
ToppCellBAL-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CENPF LMCD1 ASPM PLK1

2.28e-0417576416d4e97271df1db9a0d167fc82a90d84d20dd1f2
ToppCellBAL-Control-Lymphocyte-T/NK-Other_T|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CENPF LMCD1 ASPM PLK1

2.28e-04175764289d2aa7164bc02b1876b99f2fb67baa8e030c4e
ToppCell10x_5'_v1-Neoplastic-Stem-like-OPC-like-OPC-like|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CENPF ASPM SEMA6A PLK1

2.28e-041757648a3abf40146ae3459d97cdf865c1c8f6b92ac639
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPF ASPM CCRL2 PLK1

2.28e-041757643e56695a9db97cb1d3503425c48eb79bbf99213e
ToppCell10x_5'_v1-Neoplastic-Stem-like-OPC-like-OPC-like-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CENPF ASPM SEMA6A PLK1

2.28e-04175764378d2b79edac91fc74eee0fb42bb29dd9b07c36f
ToppCellPND03-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPF ASPM RFC2 PLK1

2.33e-041767641f8d5a48fedbb4c86272c9b5a0f1ef573350357b
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM74B AGTR1 ADGRB3 DNAH11

2.38e-04177764a8625d14682183cf77cb51eaf11bc15a3528f586
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM74B AGTR1 ADGRB3 DNAH11

2.38e-041777643645e2f4a48283f290f85c49c3e79e3f58ac9aa6
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WIPI1 CENPF ASPM PLK1

2.43e-0417876415a99080e9f669572ab6d82934f324e6714846c1
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WIPI1 CENPF ASPM PLK1

2.43e-04178764200308e109abb7e6f8816a6f8cce6d56862d4098
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RUNDC3A KIF21A ZFHX2 PNOC

2.49e-04179764b8ca29aebd25ebac441bebd769bbf98c536d3166
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-B_cells-Cycling_plasma_cell|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CENPF ASPM PLK1 PNOC

2.54e-04180764ce2fc270f9d9110c2544083f61936b0b7d3b7eb3
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A SIM2 MAP3K1 DNAH11

2.59e-041817646a6bd8e020cb0929b6ecdcb55d467ad24fecfaf0
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A SIM2 ADCY8 MAP3K1

2.59e-041817649d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCellHealthy_Control-Lymphoid-T-|Healthy_Control / Condition, Lineage, Cell class and cell subclass

CENPF ASPM PGBD1 PLK1

2.59e-04181764ac1ee313910c05b1b3cb497bae14565464919c21
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RUNDC3A KIF21A DLG2 PNOC

2.59e-041817647f99002a6411117cc2361334c7c9228e20c574b4
ToppCell10x5'-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-1|bone_marrow / Manually curated celltypes from each tissue

CENPF ASPM PLEC PLK1

2.59e-04181764ccd0ed30cea3fb41d34f28b3e8d80a94493bef3c
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-cycling_ENCC/glia|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CENPF KIF21A ASPM PLK1

2.59e-04181764f2ebeb4941510c4b6e50f2379c574d1778d6ced1
ToppCelldroplet-Lung-immune-endo-depleted-3m-Lymphocytic-T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CEP135 SIM1 PLK1 ZRANB3

2.65e-041827643948422707d6d5e021bcd7158e2eb69143613f62
ToppCellfacs-Marrow-B-cells-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WIPI1 CENPF ASPM PLK1

2.65e-041827649025178ede571e3808d4657ad4892152f336c9b4
ToppCellfacs-Marrow-B-cells-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WIPI1 CENPF ASPM PLK1

2.65e-04182764c075756cd4bb484ede1be2bcdb9eac60eab0573a
ToppCelldroplet-Lung-immune-endo-depleted-3m-Lymphocytic-Proliferating_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CEP135 SIM1 PLK1 ZRANB3

2.65e-04182764fe46819c153a81911864473badc794f243705f98
ToppCellNS-control-d_0-4-Lymphoid-NKT-proliferating|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CENPF ASPM PLK1 RPL5

2.65e-04182764f623c47e7806181d09f126066a952162ce49a306
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RUNDC3A KIF21A DLG2 PNOC

2.70e-041837647e2bac8b005155888ff4b41ef2e1d975dc17abc7
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4/8-lo-Cycling_T|bone_marrow / Manually curated celltypes from each tissue

DRP2 CENPF ASPM PLK1

2.70e-04183764a48a6313f2f144586951cece97ec31f6d72361df
ToppCellControl-T/NK-proliferating_T/NK|Control / Disease group,lineage and cell class （2021.01.30）

CENPF LMCD1 ASPM PLK1

2.70e-04183764e740f05536d1e4b2512811771928eb65f6696409
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A SIM2 MAP3K1 DNAH11

2.70e-04183764cfae90c309622b5d499e62a3a8a8b9746478d28d
ToppCell367C-Lymphocytic-NK_cells-Proliferating_NK_cell|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

CENPF CEP135 ASPM PLK1

2.70e-04183764a716b446c2bf5aa294b8f580aa845098fae76354
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell-T_cells_proliferating|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CENPF ASPM RFC2 PLK1

2.76e-04184764bba0138c8f7e3645a688b9a4d12f6f2134ee2c08
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_B-GC_B_(I)|lymph-node_spleen / Manually curated celltypes from each tissue

CENPF ASPM HFM1 PLK1

2.76e-04184764057c6c2f570914fa4af84682589a86b61547d6c9
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A SIM2 MAP3K1 DNAH11

2.76e-04184764da06ff24ee2b2cf4715fdfce43030b2da9e0aaf8
Drug(-)-quinpirole hydrochloride; Up 200; 1uM; MCF7; HG-U133A

RUNDC3A DRP2 VPS13C HPS1 GML KAT2A PHIP MAP3K1 PPP4R3A

1.96e-08197769456_UP
Drugdioxin

HIF1A ACOX1 NMT2 ARNT2 PLEC SIM1 SIM2 CA10 PHIP

2.32e-06347769CID000015625
DiseasePeptic ulcer and gastro-oesophageal reflux disease (GORD) drug use measurement

ARNT2 DNAH11

3.45e-0411752EFO_0009923
Diseaseovary epithelial cancer (is_marker_for)

ASPM PLK1

4.88e-0413752DOID:2152 (is_marker_for)
Diseasebrain measurement, neuroimaging measurement

RALGPS1 DLG2 PLEC SMIM19 MAP3K1 PPP4R3A DNAH11

5.00e-04550757EFO_0004346, EFO_0004464
DiseaseAutosomal recessive primary microcephaly

CEP135 ASPM

6.55e-0415752cv:C3711387
Diseaseneuroimaging measurement, brain volume measurement

DLG2 PLEC SMIM19 MAP3K1 PPP4R3A

8.20e-04286755EFO_0004346, EFO_0006930
DiseaseLung diseases

HIF1A HPS1 DNAH11

1.05e-0378753C0024115
DiseaseCleft Palate

INTS1 SIM2 RPL5

1.17e-0381753C0008925
DiseasePrimary microcephaly

CEP135 ASPM

1.42e-0322752C0431350
DiseaseAutosomal Recessive Primary Microcephaly

CEP135 ASPM

1.42e-0322752C3711387
Diseasepallidum volume

DLG2 SMIM19

1.84e-0325752EFO_0006933
Diseaseprimary aldosteronism

ADGRB3 GML

1.99e-0326752MONDO_0001422
Diseaseglucose tolerance test

VPS13C ABCC8

2.15e-0327752EFO_0004307

Protein segments in the cluster

PeptideGeneStartEntry
GLSMIKTIRYVRSRT

ADCY8

486

P40145
VQMRKTLRFREQRYS

CCRL2

221

O00421
SYMAVTGKIRTRLIR

ADGRB3

966

O60242
SRLRRTMLVAKVTCI

AGTR1

136

P30556
SKILRTLNRTYVNMK

DNAH11

2181

Q96DT5
ILQSRIRMIIAVTSY

ASPM

1376

Q8IZT6
QRKAVISLQSYFRMR

ASPM

1751

Q8IZT6
AITIQSSYRRLMVKK

ASPM

2461

Q8IZT6
IERRRRNKMTQYITE

ARNT2

71

Q9HBZ2
RTREYIRSLKMVPSI

RALGPS1

186

Q5JS13
LIKQRESTLGIMYRS

INTS8

741

Q75QN2
KTMTERLRSRYYVTR

KAT2A

776

Q92830
MTDTRRRVKVYTLNE

PPP4R3A

1

Q6IN85
ISLVMLRKRQYGTIS

APLP2

711

Q06481
RLITQRVSAAMYKSL

CYFIP1

766

Q7L576
SRRLIIVLSKSYMSN

IL18R1

436

Q13478
LVKVMLDLQSYRRSS

MDN1

1246

Q9NU22
PRAYAETTKMRVLRV

MAGEB6

361

Q8N7X4
LSRNMTLQRTMKLYR

NMT2

316

O60551
LSIFSRYVRRMRQSK

INTS1

1121

Q8N201
KASVMRLTISYLRVR

HIF1A

56

Q16665
YRLMIRRSIQTGTKQ

LONRF1

591

Q17RB8
RYRLVKQMLTRASIT

FAM13B

741

Q9NYF5
LRVRKVSDSSILVMY

FBXW12

446

Q6X9E4
LTMVVDYRTRVLKIS

PEA15

76

Q15121
MRVLSIKNYDSTTRI

KCNU1

431

A8MYU2
MSDTRRRVKVYTLNE

PPP4R3B

1

Q5MIZ7
YAKTMRRNTILRQAR

RPL4

331

P36578
RLLMDSKYSTLTARV

LMCD1

71

Q9NZU5
YLVLSMQSSQRRRTL

PNOC

156

Q13519
AVIMTRLSTRDKYIQ

HFM1

666

A2PYH4
MTTAVERKYINIRKR

CEP135

1

Q66GS9
RSQRYEVAVRKSAIM

ACOX1

56

Q15067
KTSPYILRRTTMATR

CENPF

2996

P49454
LVVIRTIQYNMTRTR

DYM

441

Q7RTS9
HMLKVLSYISVRRLT

SLC7A9

336

P82251
KRQKTVVRVRFYMLS

LINC00305

61

Q7Z4B0
LTKLRNTIMEQYTRT

IFIH1

701

Q9BYX4
YLMRSREITLGRATK

MCRS1

356

Q96EZ8
LRTNQKRSLYVRAMF

DLG2

531

Q15700
YLRAVMQKRISFRSP

EXOC3

606

O60645
LLVKSRRNITMVSYL

HPS1

521

Q92902
LNRMLNRDTITRITY

CA10

196

Q9NS85
MEKVQYLTRSAIRRA

PLN

1

P26678
YLTRSAIRRASTIEM

PLN

6

P26678
IDSLRAQRSRYMKLT

SEC24C

1036

P53992
MTISIRINSRELLVY

GML

56

Q99445
MALVKRFIQARRTYT

IFT140

1336

Q96RY7
YPSRAVITTMKERRV

KDSR

151

Q06136
SAYRTAMKLRRVQKA

DRP2

401

Q13474
LIFLVSYMMRTRRTL

MUCL3

466

Q3MIW9
SRRIYLSSARMVTTV

MAP3K1

816

Q13233
KRMSEYITTALRDTR

RUNDC3A

136

Q59EK9
IKLRRAMYLSDTTVT

TAS2R45

166

P59539
IYVVVRRTKLQMQTT

SFI1

196

A8K8P3
KEMLRIRRSVQATYN

XAB2

721

Q9HCS7
KPLVTTRSMEYLRFR

POLR2B

756

P30876
SIIRLTTSYLKMRAV

SIM2

41

Q14190
SIIRLTTSYLKMRVV

SIM1

41

P81133
TPKYRMIVRVTNRDI

RPL5

46

P46777
RVRNLTYMVTRREKI

JADE1

501

Q6IE81
TYMVTRREKIKRSVC

JADE1

506

Q6IE81
KMDQIISKYRVRIRS

PGBD1

741

Q96JS3
RRKEMTSLRAFAIYT

ABCC8

526

Q09428
SRKTYGSINLRMRQL

TMEM74B

216

Q9NUR3
RRYRTQMSSLQLKIM

ZFHX2

2066

Q9C0A1
TPSKRSRIYSMSLRL

PHIP

1396

Q8WWQ0
AYLMKLRRQTLTFTT

SPEG

3221

Q15772
NKARRRTTTQMELLY

KIF21A

1151

Q7Z4S6
FLRTMVRYRLTKIAV

SEMA6A

411

Q9H2E6
TISKIRLRQQLEMYS

SMIM19

71

Q96E16
VCRESRRKRKSYIVM

ZBTB44

176

Q8NCP5
LIYIVSTKSAARRSM

TRGV10

66

A0A0A0MS01
SRIYMLLQRLTTVIS

NUP188

591

Q5SRE5
RMDVQLTKLTLYRTV

VPS13C

1291

Q709C8
QQALRRTMEIYSKTT

RFC2

151

P35250
VVKSMIIDRRSGRQY

PLEC

4326

Q15149
RRGMKRYVTISSLVF

WIPI1

226

Q5MNZ9
YMKSRNATRSRILLP

ZRANB3

161

Q5FWF4
RYARTMVDKLLSSRS

PLK1

581

P53350
LRYTGMLETVRIRQS

MYO9A

936

B2RTY4