Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent diacylglycerol kinase activity	DGKI DGKZ	1.44e-04	11	33	2	GO:0004143
Domain	DAGK_acc	DGKI DGKZ	1.19e-04	10	31	2	PF00609
Domain	DAGKa	DGKI DGKZ	1.19e-04	10	31	2	SM00045
Domain	Diacylglycerol_kin_accessory	DGKI DGKZ	1.19e-04	10	31	2	IPR000756
Domain	DAGKc	DGKI DGKZ	2.40e-04	14	31	2	SM00046
Domain	DAGK	DGKI DGKZ	2.76e-04	15	31	2	PS50146
Domain	Diacylglycerol_kinase_cat_dom	DGKI DGKZ	2.76e-04	15	31	2	IPR001206
Domain	DAGK_cat	DGKI DGKZ	2.76e-04	15	31	2	PF00781
Domain	NAD/diacylglycerol_kinase	DGKI DGKZ	3.57e-04	17	31	2	IPR016064
Domain	Plexin_repeat	ATRN PLXND1	1.28e-03	32	31	2	IPR002165
Domain	PSI	ATRN PLXND1	1.28e-03	32	31	2	PF01437
Domain	PSI	ATRN PLXND1	2.42e-03	44	31	2	IPR016201
Domain	PSI	ATRN PLXND1	2.64e-03	46	31	2	SM00423
Domain	C1_1	DGKI DGKZ	4.02e-03	57	31	2	PF00130
Domain	ZF_DAG_PE_1	DGKI DGKZ	5.04e-03	64	31	2	PS00479
Domain	ZF_DAG_PE_2	DGKI DGKZ	5.04e-03	64	31	2	PS50081
Domain	C1	DGKI DGKZ	5.20e-03	65	31	2	SM00109
Domain	PE/DAG-bd	DGKI DGKZ	5.35e-03	66	31	2	IPR002219
Domain	Ankyrin_rpt	DGKI TRPM4 DGKZ	9.18e-03	262	31	3	IPR002110
Domain	Rho_GTPase_activation_prot	PLXND1 FAM13B	9.34e-03	88	31	2	IPR008936
Pathway	KEGG_MEDICUS_REFERENCE_DNA_END_RESECTION_AND_RPA_LOADING	BLM RBBP8	3.19e-04	18	21	2	M47838
Pathway	REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS	CHST9 CSPG5	3.56e-04	19	21	2	MM14800
Pathway	REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS	CHST9 CSPG5	3.95e-04	20	21	2	M658
Pathway	REACTOME_REGULATION_OF_IFNA_IFNB_SIGNALING	PTPN1 IFNA6	5.25e-04	23	21	2	MM15634
Pathway	REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS	DGKI DGKZ	6.21e-04	25	21	2	MM14511
Pathway	REACTOME_HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE	BLM RBBP8	6.72e-04	26	21	2	MM15297
Pathway	REACTOME_REGULATION_OF_IFNA_IFNB_SIGNALING	PTPN1 IFNA6	6.72e-04	26	21	2	M982
Pathway	REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS	DGKI DGKZ	7.25e-04	27	21	2	M12123
Pathway	REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES_THROUGH_SYNTHESIS_DEPENDENT_STRAND_ANNEALING_SDSA	BLM RBBP8	7.25e-04	27	21	2	M27586
Pathway	REACTOME_GLYCOSAMINOGLYCAN_METABOLISM	CHST9 CSPG5 CHP1	7.69e-04	123	21	3	MM14623
Pathway	REACTOME_GLYCOSAMINOGLYCAN_METABOLISM	CHST9 CSPG5 CHP1	8.24e-04	126	21	3	M695
Pathway	PID_ATM_PATHWAY	BLM RBBP8	1.15e-03	34	21	2	M84
Pathway	REACTOME_INTERFERON_ALPHA_BETA_SIGNALING	PTPN1 IFNA6	1.15e-03	34	21	2	MM15631
Pathway	REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES	BLM RBBP8	1.22e-03	35	21	2	MM15293
Pathway	REACTOME_HDR_THROUGH_SINGLE_STRAND_ANNEALING_SSA	BLM RBBP8	1.29e-03	36	21	2	MM15281
Pathway	REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES	BLM RBBP8	1.36e-03	37	21	2	M27583
Pathway	REACTOME_HDR_THROUGH_SINGLE_STRAND_ANNEALING_SSA	BLM RBBP8	1.36e-03	37	21	2	M27568
Pathway	REACTOME_HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE	BLM RBBP8	1.84e-03	43	21	2	M27588
Pathway	REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM	CHST9 CSPG5	2.29e-03	48	21	2	MM14696
Pathway	KEGG_GLYCEROLIPID_METABOLISM	DGKI DGKZ	2.38e-03	49	21	2	M15902
Pathway	REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM	CHST9 CSPG5	2.48e-03	50	21	2	M678
Pathway	REACTOME_DISEASES_OF_DNA_REPAIR	BLM RBBP8	2.58e-03	51	21	2	M29854
Pathway	REACTOME_HDR_THROUGH_HOMOLOGOUS_RECOMBINATION_HRR	BLM RBBP8	3.44e-03	59	21	2	MM15283
Pubmed	A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger.	STK17B CHP1	8.73e-07	2	33	2	11481038
Pubmed	Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling.	DGKI DGKZ	5.23e-06	4	33	2	15894621
Pubmed	PLK1-mediated phosphorylation of PPIL2 regulates HR via CtIP.	BLM RBBP8	8.72e-06	5	33	2	36092721
Pubmed	Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.	BLM RBBP8	2.44e-05	8	33	2	23254285
Pubmed	Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice.	BLM RBBP8	3.13e-05	9	33	2	24705021
Pubmed	β-Catenin in the kidney stroma modulates pathways and genes to regulate kidney development.	PLXND1 ALX1	4.78e-05	11	33	2	37227110
Pubmed	Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling.	DGKI DGKZ	4.78e-05	11	33	2	17021016
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	ATRN PTPN1 TRPM4 NTAQ1 CHP1	1.02e-04	499	33	5	22810586
Pubmed	A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.	SUGP1 CILP2	1.48e-04	19	33	2	19656773
Pubmed	TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B.	PTPN1 IFNA6	1.64e-04	20	33	2	11694501
Pubmed	The sperm-associated antigen 6 interactome and its role in spermatogenesis.	CDKL3 DGKZ NUFIP1	8.87e-04	199	33	3	31146259
Cytoband	18q11.2	CHST9 RBBP8	5.31e-04	47	33	2	18q11.2
Cytoband	19p13.11	SUGP1 CILP2	1.28e-03	73	33	2	19p13.11
Cytoband	19q13.41	ZNF613 KLK3	1.45e-03	78	33	2	19q13.41
Cytoband	Ensembl 112 genes in cytogenetic band chr18q11	CHST9 RBBP8	1.72e-03	85	33	2	chr18q11
Cytoband	20p13	ATRN SLC24A3	2.47e-03	102	33	2	20p13
Cytoband	5q31	CDKL3 FAM13B	3.12e-03	115	33	2	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr15q15	STARD9 CHP1	5.04e-03	147	33	2	chr15q15
GeneFamily	EF-hand domain containing\|Diacylglycerol kinases	DGKI DGKZ	8.20e-05	10	25	2	1178
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF28P STARD9	1.83e-03	46	25	2	622
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CDKL3 PLXND1 CCDC141 STARD9	7.74e-06	172	33	4	a9e13aa36087170dadca421ba9de588e5a1cf715
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	CDKL3 CCDC141 STARD9 NTAQ1	8.29e-06	175	33	4	f3a68aeb79c4935006e17a5ff3445a8ec0e33f5f
Disease	dental caries	CHST9 DYM KLK3 CCDC141	4.89e-05	187	32	4	EFO_0003819
Disease	complex trait	SUGP1 DYM CCDC141 RBBP8	2.04e-04	271	32	4	EFO_0010578
Disease	IGF-1 measurement	PTPN1 DGKZ STARD9 NUFIP1	1.84e-03	488	32	4	EFO_0004627
Disease	asthma, response to diisocyanate	BLM ATRN NUFIP1	2.81e-03	261	32	3	EFO_0006995, MONDO_0004979
Disease	gut microbiome measurement, bone density	SLC24A3 CCDC141	3.25e-03	78	32	2	EFO_0003923, EFO_0007874
Disease	migraine disorder, Headache	SLC24A3 DGKZ	3.93e-03	86	32	2	HP_0002315, MONDO_0005277
Disease	colorectal cancer, hormone replacement therapy	CCDC15 SLC24A3	4.12e-03	88	32	2	EFO_0003961, MONDO_0005575

Protein segments in the cluster

Peptide	Gene	Start	Entry
NGHAFETKPEFERRS	ALX1	291	Q15699
KNVHLSSDNPDFRDE	ERICH3	296	Q5RHP9
NKFRTPSELHNDNFS	CSPG5	461	O95196
FKGDERETSLQNFPH	RBBP8	781	Q99708
KLNFSRSDRKEFHFP	CDKL3	511	Q8IVW4
KNRNRYRDVSPFDHS	PTPN1	41	P18031
DSFSNEKFDFRNHPN	ATRN	1236	O75882
DFGQSQRFLHDPEKL	FAM13B	526	Q9NYF5
FPRNRSLEDHRFENT	PLXND1	221	Q9Y4D7
ALHEFPNDIFTNEDR	SLC24A3	91	Q9HC58
SRNLKHERFQSLSFP	BLM	636	P54132
CNDKRETFSSHFERP	CCDC141	1276	Q6ZP82
RDLFEQFRTHPSFQD	DYM	561	Q7RTS9
LEFHESREANPEKFN	DGKI	541	O75912
FDPLRFSQENSDQRH	CYP4X1	426	Q8N118
HNDKPFSTVDRDRDS	ANGPTL6	391	Q8NI99
LEFHESREANPEKFN	DGKZ	461	Q13574
DPSRKFAGQRDVFHD	KIF28P	76	B7ZC32
FKSDDDIHPQFRRKF	NTAQ1	116	Q96HA8
SCLKDRHDFRFPQEE	IFNA6	51	P05013
SAYEQHKIRRPDSFD	ITPRIPL2	161	Q3MIP1
SKRFRFDDSLPNPHE	STK17B	351	O94768
FLEKPQFSTELRDHN	STARD9	3171	Q9P2P6
LSRPSLNKDFRDHAE	INIP	46	Q9NRY2
DFLPKDQDFLSRDQH	CCDC15	531	Q0P6D6
RTDHDDPAFKRNGFR	CILP2	846	Q8IUL8
KFPNFKDRHSSDERT	CHST9	391	Q7L1S5
EPLNSRSNKLHFAFR	CHP1	106	Q99653
DNPAFAFLHDKNSRE	SUGP1	216	Q8IWZ8
RQSSDRFPRHQKSFN	NUFIP1	121	Q9UHK0
RKSDFPLRQNHDTFD	ZNF613	116	Q6PF04
KHSNFLRLSDRTDPA	TRPM4	86	Q8TD43
LKNRFLRPGDDSSHD	KLK3	106	P07288