Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentacrosomal vesicle

TEKT3 SPATA31A1 SPATA31A3 SPATA31A7 SPATA31C1 SPATA31A5

3.62e-05206636GO:0001669
GeneOntologyCellularComponentmulti-pass translocon complex

NOMO2 NOMO3

3.17e-049632GO:0160064
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31C1 SPATA31A5

4.07e-0812584PF15371
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31C1 SPATA31A5

4.07e-0812584IPR027970
DomainSEA

MUC3B MUC16 ADGRF1

4.20e-0522583PF01390
DomainSEA

MUC3B MUC16 ADGRF1

4.82e-0523583PS50024
DomainSEA_dom

MUC3B MUC16 ADGRF1

4.82e-0523583IPR000082
DomainDUF2012

NOMO2 NOMO3

5.66e-054582PF09430
DomainDUF2012

NOMO2 NOMO3

5.66e-054582IPR019008
DomainCarb-bd-like_fold

NOMO2 NOMO3

2.62e-048582IPR013784
DomainCarboxyPept_regulatory_dom

NOMO2 NOMO3

7.23e-0413582IPR014766
Domain-

NOMO2 NOMO3

7.23e-04135822.60.40.1120
DomainSEA

MUC3B MUC16

8.42e-0414582SM00200
DomainCarboxyPept-like_regulatory

NOMO2 NOMO3

1.25e-0317582IPR008969
DomainSNF2_N

ERCC6 CHD9

4.43e-0332582IPR000330
DomainSNF2_N

ERCC6 CHD9

4.43e-0332582PF00176
DomainHelicase_C

BLM ERCC6 CHD9

4.49e-03107583PF00271
DomainHELICc

BLM ERCC6 CHD9

4.49e-03107583SM00490
DomainHelicase_C

BLM ERCC6 CHD9

4.61e-03108583IPR001650
DomainHELICASE_CTER

BLM ERCC6 CHD9

4.73e-03109583PS51194
DomainHELICASE_ATP_BIND_1

BLM ERCC6 CHD9

4.73e-03109583PS51192
DomainDEXDc

BLM ERCC6 CHD9

4.73e-03109583SM00487
DomainHelicase_ATP-bd

BLM ERCC6 CHD9

4.85e-03110583IPR014001
DomainGPS

ADGRF1 ADGRG4

4.99e-0334582SM00303
DomainGPS

ADGRF1 ADGRG4

5.28e-0335582PF01825
DomainGPS

ADGRF1 ADGRG4

5.58e-0336582PS50221
DomainGPS

ADGRF1 ADGRG4

5.89e-0337582IPR000203
DomainANF_lig-bd_rcpt

GRID1 GRM5

5.89e-0337582IPR001828
DomainANF_receptor

GRID1 GRM5

5.89e-0337582PF01094
Pubmed

The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.

SPATA31A1 SPATA31A3 SPATA31A7 SPATA31C1 SPATA31A5

9.93e-14663520850414
Pubmed

Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.

SPATA31A1 SPATA31A3 SPATA31A7 SPATA31C1 SPATA31A5

9.93e-14663525930072
Pubmed

Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.

SPATA31A1 SPATA31A3 SPATA31A7 SPATA31C1 SPATA31A5

6.86e-102463532212159
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

KMT2D TCF7L2 HIVEP1 BICRA CECR2 PCLO C15orf39 SIX5

6.13e-0739863835016035
Pubmed

The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.

ERCC6 PGBD3

3.23e-06263222483866
Pubmed

Glutamate Delta-1 Receptor Regulates Metabotropic Glutamate Receptor 5 Signaling in the Hippocampus.

GRID1 GRM5

3.23e-06263227231330
Pubmed

Mutant Cockayne syndrome group B protein inhibits repair of DNA topoisomerase I-DNA covalent complex.

ERCC6 PGBD3

3.23e-06263221143350
Pubmed

What role (if any) does the highly conserved CSB-PGBD3 fusion protein play in Cockayne syndrome?

ERCC6 PGBD3

3.23e-06263223369858
Pubmed

An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome.

ERCC6 PGBD3

3.23e-06263218369450
Pubmed

Human transcription factor protein interaction networks.

BLM KMT2D TCF7L2 HIVEP1 HOXC11 BICRA PRRC2C PABPC3 SVIL MDC1 C15orf39 SIX5

8.45e-061429631235140242
Pubmed

Tethering of the conserved piggyBac transposase fusion protein CSB-PGBD3 to chromosomal AP-1 proteins regulates expression of nearby genes in humans.

ERCC6 PGBD3

9.68e-06363223028371
Pubmed

Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.

NOMO2 NOMO3

9.68e-06363236011023
Pubmed

Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.

NOMO2 NOMO3

9.68e-06363225576386
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

BLM CASP8AP2 SYNRG HIVEP1 NOMO2 PRRC2C C15orf39 TRIM37

1.09e-0558863838580884
Pubmed

Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.

NOMO2 NOMO3

1.93e-05463231833031
Pubmed

The associations between single nucleotide polymorphisms of DNA repair genes, DNA damage, and age-related cataract: Jiangsu Eye Study.

BLM ERCC6

1.93e-05463223322570
Pubmed

A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.

NOMO2 NOMO3

1.93e-0546329267806
Pubmed

Interaction network of human early embryonic transcription factors.

KMT2D TCF7L2 HIVEP1 BICRA MDC1 C15orf39

4.24e-0535163638297188
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

CASP8AP2 CECR2 PIEZO1 MDC1 SERTAD2 CEP126 ARHGEF10L

4.80e-0552963714621295
Pubmed

Genetic variation in the DNA repair genes is predictive of outcome in lung cancer.

BLM ERCC6

6.74e-05763217855454
Pubmed

Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions.

ADGRF1 ADGRG4

8.98e-05863212435584
Pubmed

Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.

NOMO2 NOMO3

8.98e-05863215257293
Pubmed

Substrate-driven assembly of a translocon for multipass membrane proteins.

NOMO2 NOMO3

1.15e-04963236261522
Pubmed

Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.

NOMO2 BICRA CECR2 PCLO C15orf39 NOMO3

1.21e-0442563624999758
Pubmed

An ER translocon for multi-pass membrane protein biogenesis.

NOMO2 NOMO3

1.76e-041163232820719
Pubmed

Multiple roles of integrin-α3 at the neuromuscular junction.

CACNA1A PCLO

2.11e-041263228386022
Pubmed

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.

TCF7L2 APOB

2.49e-041363217463246
Pubmed

Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones.

CACNA1A PCLO

2.90e-041463221228161
Pubmed

The G protein-coupled receptor repertoires of human and mouse.

GRM5 ADGRF1 ADGRG4

4.06e-047963312679517
Pubmed

LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization.

PRRC2C MDC1

4.32e-041763237072811
Pubmed

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

BLM KMT2D

4.85e-041863217500065
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

BLM SYNRG KMT2D HIVEP1 SVIL MDC1 IQCK

4.94e-0477463715302935
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

SYCP2 HIVEP1 RIPK3 PRRC2C MDC1

5.03e-0436163526167880
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PCLO CHD9 TRIM37

5.39e-048763312465718
Pubmed

A genome-wide association study of the metabolic syndrome in Indian Asian men.

TCF7L2 CRTAC1

5.41e-041963220694148
Pubmed

Phosphoproteome analysis of the human mitotic spindle.

BLM ERCC6 PIEZO1 CDCA7L

5.82e-0421063416565220
Pubmed

Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

NOMO2 NOMO3 IQCK

6.34e-049263310493829
Pubmed

Sox2 modulates the function of two distinct cell lineages in mouse skin.

CACNA1A PCLO

6.63e-042163223948231
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

PPP2R3A CECR2 PCLO MDC1 MUC16

7.63e-0439663526687479
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

PPP2R3A HIVEP1 SIX5 TRIM37 NOMO3 RBFOX2

8.13e-0460863616713569
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

BLM TCF7L2 HIVEP1 ERCC6 MDC1 CHD9

8.13e-0460863636089195
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SYNRG KMT2D BICRA PIEZO1 C15orf39 GRID1 ZNF324B ARHGEF10L

8.34e-04110563835748872
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

CACNA1A HIVEP1 C15orf39 SIX5

8.58e-0423363437704626
Pubmed

Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development.

TBX15 APOB

9.43e-042563221784065
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

SYNPO2 TCF7L2 TOB1 BICRA MDC1

1.10e-0343063535044719
Pubmed

USP7 Regulates Cytokinesis through FBXO38 and KIF20B.

BLM HIVEP1 NOMO2

1.24e-0311663330804394
Pubmed

The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.

ADGRF1 ADGRG4

1.27e-032963215203201
Pubmed

The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing.

PRRC2C MDC1

1.27e-032963217577209
Pubmed

Obesity and diabetes genetic variants associated with gestational weight gain.

TCF7L2 TMEM18

1.27e-032963220816152
Pubmed

TopBP1 controls BLM protein level to maintain genome stability.

BLM MDC1

1.27e-032963224239288
Pubmed

Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.

BLM KMT2D CDCA7L

1.34e-0311963323508102
Pubmed

The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression.

BLM CASP8AP2 TCF7L2

1.34e-0311963324162774
Pubmed

Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies.

BLM ERCC6

1.45e-033163220813000
Pubmed

Hepatic lipase maturation: a partial proteome of interacting factors.

NOMO2 NOMO3

1.45e-033163219136429
Pubmed

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.

ADGRF1 ADGRG4

1.64e-033363225713288
Pubmed

An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.

NOMO2 NOMO3

1.64e-033363230783098
CytobandEnsembl 112 genes in cytogenetic band chr9q12

SPATA31A7 SPATA31A5

5.16e-058632chr9q12
Cytoband10q22

GRID1 CRTAC1

2.80e-041863210q22
Cytoband9p13.1

SPATA31A1 SPATA31A3

5.02e-04246329p13.1
Cytoband16p12.3

NOMO2 IQCK

1.01e-033463216p12.3
GeneFamilyCD molecules|Mucins

MUC3B MUC16

6.64e-0421332648
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

BLM PPP2R3A TCF7L2 HIVEP1 PRRC2C CHD9 TRIM37 RBFOX2

9.42e-06466598M13522
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYCP2 PCLO GRID1 APOB USH2A OTOG

2.19e-07184626ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYCP2 PCLO GRID1 APOB USH2A OTOG

2.19e-071846262cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYCP2 PCLO GRID1 APOB USH2A OTOG

2.19e-071846262b19a8c5f823e00812908b23e66bb4e563278aff
Druggenistein; Down 200; 10uM; MCF7; HT_HG-U133A_EA

PPP2R3A SYCP2 TCF7L2 BICRA PRRC2C SERTAD2 C15orf39

6.76e-071975871015_DN
DrugArcaine sulfate [14923-17-2]; Down 200; 14.8uM; HL60; HT_HG-U133A

TCF7L2 ERCC6 ZNF324 ZNF324B ALDH6A1 RBFOX2 ARHGEF10L

7.48e-072005873010_DN
Drugpure blue

ERCC6 TOB1 PGBD3

8.71e-078583CID005388082
Drugazotochelin

ERCC6 PGBD3

6.38e-062582CID000193592
Drug1g4o

BLM ERCC6 PGBD3

6.98e-0615583CID000004347
DrugICI 182,780; Down 200; 0.01uM; HL60; HT_HG-U133A

SYNRG BTN2A2 TCF7L2 BICRA PIEZO1 SVIL

9.92e-061945861179_DN
DrugSulfadiazine [68-35-9]; Down 200; 16uM; PC3; HT_HG-U133A

TCF7L2 BICRA ZNF324 C15orf39 ADGRF1 ALDH6A1

1.08e-051975861810_DN
Drugfs x

SIX5 PAPSS1 RBFOX2

2.68e-0523583CID000444420
Diseasetype 2 diabetes mellitus, metabolic syndrome

TCF7L2 CRTAC1

3.80e-062582EFO_0000195, MONDO_0005148
Diseaseattention deficit hyperactivity disorder, bipolar disorder, autism spectrum disorder, schizophrenia, major depressive disorder

TCF7L2 PCLO GRM5

1.40e-0451583EFO_0003756, EFO_0003888, MONDO_0002009, MONDO_0004985, MONDO_0005090
DiseaseMicrophthalmos

KMT2D ERCC6

2.06e-0411582C0026010
Diseasecognitive function measurement

SYNPO2 KMT2D TCF7L2 HIVEP1 PRRC2C PIEZO1 GRID1 USH2A TRIM37 CDCA7L

4.41e-0414345810EFO_0008354
Diseasemetabolic syndrome

PPP2R3A CRTAC1 APOB TMEM18

6.53e-04200584EFO_0000195
Diseaseclinical and behavioural ideal cardiovascular health

TCF7L2 TMEM18

9.36e-0423582EFO_0007654
Diseasesex interaction measurement, body mass index, age at assessment

TCF7L2 TMEM18

9.36e-0423582EFO_0004340, EFO_0008007, EFO_0008343
DiseaseCoronary heart disease

TCF7L2 APOB

1.02e-0324582C0010068
Diseaseneurotic disorder

HIVEP1 PCLO GRM5

1.05e-03101583EFO_0004257
Diseaseunipolar depression, irritable bowel syndrome

TCF7L2 PCLO

1.39e-0328582EFO_0000555, EFO_0003761
Diseasedepressive symptom measurement

CACNA1A TCF7L2 HIVEP1 PCLO GRM5

1.50e-03426585EFO_0007006
Diseaseresponse to aromatase inhibitor

SVIL MUC16

1.81e-0332582GO_0061477
Diseasesmoking behavior, body mass index

TCF7L2 GRID1 TMEM18

1.85e-03123583EFO_0004318, EFO_0004340
Diseasepuberty onset measurement

ZNF324 ZNF324B TMEM18

1.93e-03125583EFO_0005677

Protein segments in the cluster

PeptideGeneStartEntry
PPTNFDTFPAAIMTV

CACNA1A

646

O00555
GRPISFMVVFITPNP

ARHGEF10L

726

Q9HCE6
ILMSPFVPSTIFPVV

ADGRF1

571

Q5T601
ATPVPVTHMFSLPVN

ADGRG4

1006

Q8IZF6
TTAFSVPNVPTMLPR

ADGRG4

1486

Q8IZF6
FPSPMEIQQTESLFP

CASP8AP2

681

Q9UKL3
FPQVAHPMSVTVSAP

CECR2

936

Q9BXF3
PQTFPLTVTDRPVMD

NOMO3

481

P69849
TTPDAMVQPFTTIPF

RBFOX2

26

O43251
PVSHFTMISRTPCPQ

IQCK

101

Q8N0W5
VTAPPNDFFTVMRTP

ERCC6

596

P0DP91
PVPLPMFSFTGSRSS

ALDH6A1

476

Q02252
PPKVTSPMVTSFNIR

MUC16

6616

Q8WXI7
SIPSSTAATVPFMVP

MUC16

12061

Q8WXI7
PQTFPLTVTDRPVMD

NOMO2

481

Q5JPE7
PTTMTTFAEIQPLPA

GRM5

1106

P41594
SSTVRAMPVPTTPEF

MDC1

1686

Q14676
TVMQPVSPSRSFPIF

C9orf131

156

Q5VYM1
PTFQAVATMSFTPQV

PCLO

3926

Q9Y6V0
NSMPDFFPVRTPTSA

CDCA7L

236

Q96GN5
ISNMPSLQLTPFSPV

PPP2R3A

311

Q06190
PFSTMRPASSQVPRV

PABPC3

456

Q9H361
RSPDDIPFMTPNTIT

NLGN4Y

766

Q8NFZ3
LNPETTVVAIFPSPM

PAPSS1

481

O43252
MPTFHVPFTDLQVPS

APOB

3746

P04114
PRVMSPENFPTASVE

CHD9

546

Q3L8U1
PTFSVPTSVMQPIYE

CHD9

1806

Q3L8U1
FPSVPVMALTATANP

BLM

821

P54132
NSVPFVSSPPMFVLD

CEP126

366

Q9P2H0
MPEFSTVSSFLPQAP

HOXC11

41

O43248
FRQSPVKTPIPMSFQ

GRID1

976

Q9ULK0
AEPMFTAVTNSVLPP

CRTAC1

31

Q9NQ79
TVIFIPESFMPSASP

BTN2A2

236

Q8WVV5
RTFQMVTTPFPALPQ

BICRA

941

Q9NZM4
FMLPVSTPPNSIAFA

SLC13A3

521

Q8WWT9
FVFGVLSLMSTVPPT

DEFB131B

6

A0A096LNP1
TLSPVLPFTPAAMTQ

OTOG

1856

Q6ZRI0
PPNDFFTVMRTPTEI

PGBD3

131

Q8N328
PLTVFPFTTEMVTCP

MUC3B

716

Q9H195
RTGESAPVFMIPPSV

USH2A

1356

O75445
MASFVTTPVPPDFTS

TRIM37

256

O94972
PARAPSVVSSMPFLQ

SVIL

2021

O95425
FSMTLPTPVSQPTVI

SYNRG

391

Q9UMZ2
LNSLTPASPTEVPFM

NBPF11

796

Q86T75
PFISSTPQFRPTPMA

SPATA31A7

481

Q8IWB4
ATQPSETFMPQRTPS

TBX15

431

Q96SF7
FQSAPATVRMTQPFP

PRRC2C

2711

Q9Y520
ATVRMTQPFPTQFAP

PRRC2C

2716

Q9Y520
TFPTSMLVSQVLPPA

SIX5

566

Q8N196
RPTPTNFLPAISTMA

TEKT3

16

Q9BXF9
PFISSTPQFRPTPMA

SPATA31C1

341

P0DKV0
SSPPMPVIDNVFSLA

C15orf39

496

Q6ZRI6
PFISSTPQFRPTPMA

SPATA31A3

481

Q5VYP0
RAFPDTPPGMTTSVF

ZNF324

96

O75467
TPFSPTRNMTSPIAD

SYNPO2

601

Q9UMS6
PFISSTPQFRPTPMA

SPATA31A1

481

Q5TZJ5
SMAQPPQTPETSTFR

RIPK3

391

Q9Y572
PFISSTPQFRPTPMA

SPATA31A5

481

Q5VU36
SLRPMFTPSSQPTTE

SERTAD2

81

Q14140
TMRSPVLFSNTSIPP

SYCP2

491

Q9BX26
PTALTVNASMSRFPP

TCF7L2

281

Q9NQB0
AAVSPTFMPRSTQPL

TOB1

161

P50616
PLFTMSAQQPSIIPF

PIEZO1

2221

Q92508
PSSFMLPIRLQSSVP

HIVEP1

1631

P15822
MPSAFSVSSFPVSIP

TMEM18

1

Q96B42
RAFPDTPPGMTTSVF

ZNF324B

96

Q6AW86
AFVGTPSPMRFTFPQ

KMT2D

2526

O14686
PVTVPLATMSVVFTF

NALCN

1236

Q8IZF0