Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone modifying activity	HDAC9 NCOA3 RNF2 RNF20 HAT1 TAF1 ATM TRIM37	1.17e-05	229	93	8	GO:0140993
GeneOntologyMolecularFunction	histone ubiquitin ligase activity	RNF2 RNF20 TRIM37	2.09e-05	12	93	3	GO:0140852
GeneOntologyMolecularFunction	small GTPase binding	ATP6AP1 FGD4 DOCK9 DVL2 DVL3 AKAP13 FMNL2 IPO11	1.27e-04	321	93	8	GO:0031267
GeneOntologyMolecularFunction	histone H2AK119 ubiquitin ligase activity	RNF2 TRIM37	1.28e-04	4	93	2	GO:0140862
GeneOntologyMolecularFunction	GTPase binding	ATP6AP1 FGD4 DOCK9 DVL2 DVL3 AKAP13 FMNL2 IPO11	2.77e-04	360	93	8	GO:0051020
GeneOntologyMolecularFunction	histone H2A ubiquitin ligase activity	RNF2 TRIM37	3.18e-04	6	93	2	GO:0141053
GeneOntologyCellularComponent	microtubule plus-end	NUMA1 DCTN1 CLIP1	2.66e-04	28	94	3	GO:0035371
GeneOntologyCellularComponent	spindle	KIFAP3 STAG1 TTC28 SHCBP1 NUMA1 ATM DCTN1 TBL1XR1 ANKFN1	2.71e-04	471	94	9	GO:0005819
GeneOntologyCellularComponent	histone methyltransferase complex	HDAC9 RNF2 TAF1 TRIM37	3.65e-04	75	94	4	GO:0035097
GeneOntologyCellularComponent	endoplasmic reticulum-Golgi intermediate compartment	ATP6AP1 SURF4 UGGT2 DICER1 GOLGA3	4.41e-04	141	94	5	GO:0005793
GeneOntologyCellularComponent	microtubule end	NUMA1 DCTN1 CLIP1	6.63e-04	38	94	3	GO:1990752
GeneOntologyCellularComponent	inclusion body	KLF8 DVL2 PSMC4 TRIM37	7.29e-04	90	94	4	GO:0016234
GeneOntologyCellularComponent	aggresome	KLF8 DVL2 TRIM37	7.71e-04	40	94	3	GO:0016235
GeneOntologyCellularComponent	mitotic spindle pole	STAG1 TTC28 NUMA1	9.54e-04	43	94	3	GO:0097431
GeneOntologyCellularComponent	cohesin complex	STAG1 STAG3	1.07e-03	11	94	2	GO:0008278
GeneOntologyCellularComponent	proteasome regulatory particle, base subcomplex	PSMC4 PSMD4	1.28e-03	12	94	2	GO:0008540
GeneOntologyCellularComponent	methyltransferase complex	HDAC9 RNF2 TAF1 TRIM37	1.44e-03	108	94	4	GO:0034708
Domain	ARM-type_fold	KIFAP3 HIP1 STAG1 CEBPZ MROH2B DOCK9 ATM FMNL2 STAG3 IPO11	7.23e-06	339	93	10	IPR016024
Domain	Dsh_C	DVL2 DVL3	7.33e-05	3	93	2	PF12316
Domain	Dishevelled_C-dom	DVL2 DVL3	7.33e-05	3	93	2	IPR024580
Domain	Dsh/Dvl-rel	DVL2 DVL3	1.46e-04	4	93	2	IPR015506
Domain	STAG	STAG1 STAG3	1.46e-04	4	93	2	IPR013721
Domain	Dishevelled_fam	DVL2 DVL3	1.46e-04	4	93	2	IPR008339
Domain	Dishevelled	DVL2 DVL3	1.46e-04	4	93	2	PF02377
Domain	SCD	STAG1 STAG3	1.46e-04	4	93	2	PS51425
Domain	SCD	STAG1 STAG3	1.46e-04	4	93	2	IPR020839
Domain	Dishevelled_protein_dom	DVL2 DVL3	1.46e-04	4	93	2	IPR003351
Domain	STAG	STAG1 STAG3	1.46e-04	4	93	2	PF08514
Domain	-	PIK3AP1 ASAP3 ANKS1B AKAP13 ANKRD18A ZDHHC17 ANKFN1	2.40e-04	248	93	7	1.25.40.20
Domain	VWA_2	INTS6 PSMD4	2.43e-04	5	93	2	PF13519
Domain	Ankyrin_rpt-contain_dom	PIK3AP1 ASAP3 ANKS1B AKAP13 ANKRD18A ZDHHC17 ANKFN1	2.78e-04	254	93	7	IPR020683
Domain	FYVE	ZFYVE16 FGD4 MTMR3	3.98e-04	29	93	3	PF01363
Domain	FYVE	ZFYVE16 FGD4 MTMR3	3.98e-04	29	93	3	SM00064
Domain	DIX	DVL2 DVL3	5.07e-04	7	93	2	PF00778
Domain	DIX	DVL2 DVL3	5.07e-04	7	93	2	IPR001158
Domain	DIX	DVL2 DVL3	5.07e-04	7	93	2	PS50841
Domain	DAX	DVL2 DVL3	5.07e-04	7	93	2	SM00021
Domain	Znf_FYVE-rel	ZFYVE16 FGD4 MTMR3	6.40e-04	34	93	3	IPR017455
Domain	-	FGD4 CADPS DOCK9 ITSN1 ASAP3 MTMR3 ANKS1B AKAP13	7.43e-04	391	93	8	2.30.29.30
Domain	Znf_FYVE	ZFYVE16 FGD4 MTMR3	8.89e-04	38	93	3	IPR000306
Domain	PH	FGD4 CADPS DOCK9 ITSN1 ASAP3 AKAP13	9.98e-04	229	93	6	PF00169
Domain	ZF_FYVE	ZFYVE16 FGD4 MTMR3	1.03e-03	40	93	3	PS50178
Domain	CAP_GLY	DCTN1 CLIP1	1.08e-03	10	93	2	PF01302
Domain	CAP_GLY_1	DCTN1 CLIP1	1.08e-03	10	93	2	PS00845
Domain	CAP_GLY_2	DCTN1 CLIP1	1.08e-03	10	93	2	PS50245
Domain	CAP-Gly_domain	DCTN1 CLIP1	1.08e-03	10	93	2	IPR000938
Domain	CAP_GLY	DCTN1 CLIP1	1.08e-03	10	93	2	SM01052
Domain	-	DCTN1 CLIP1	1.08e-03	10	93	2	2.30.30.190
Domain	PH_dom-like	FGD4 CADPS DOCK9 ITSN1 ASAP3 MTMR3 ANKS1B AKAP13	1.29e-03	426	93	8	IPR011993
Domain	-	ZMYND11 RNF2 ZFYVE16 ZNF341 FGD4 RNF20 MTMR3 TRIM37	1.79e-03	449	93	8	3.30.40.10
Domain	Znf_RING/FYVE/PHD	ZMYND11 RNF2 ZFYVE16 ZNF341 FGD4 RNF20 MTMR3 TRIM37	2.06e-03	459	93	8	IPR013083
Domain	PH	FGD4 CADPS DOCK9 ITSN1 ASAP3 AKAP13	2.66e-03	278	93	6	SM00233
Domain	PH_DOMAIN	FGD4 CADPS DOCK9 ITSN1 ASAP3 AKAP13	2.71e-03	279	93	6	PS50003
Domain	PH_domain	FGD4 CADPS DOCK9 ITSN1 ASAP3 AKAP13	2.76e-03	280	93	6	IPR001849
Domain	RhoGEF	FGD4 ITSN1 AKAP13	4.74e-03	68	93	3	SM00325
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	RABL6 EHBP1 HIP1 TTC28 ZFYVE16 SURF4 ITSN1 DVL2 DVL3 CCT8 PSMC4 PSMD4 GOLGA3	3.56e-10	449	96	13	31732153
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	HDAC9 ZNF821 STAG1 TTC28 TJP1 CADPS NFE2L2 ITSN1 MTMR3 DVL3 ANKS1B PSMD4 TAF1 ATM DCTN1 FMNL2 TRIM37 DCAF5 GOLGA3	2.01e-09	1285	96	19	35914814
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	EHBP1 PPP1R7 KIFAP3 NCOA3 RNF2 SURF4 DVL3 PSMC4 UGGT2 MAGT1 NOPCHAP1 DCTN1 FMNL2 CLIP1 CTSV DICER1 NDUFS1 CRTC2 IPO11	3.15e-09	1321	96	19	27173435
Pubmed	Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.	RABL6 EHBP1 ZFYVE16 TJP1 ITSN1 NUMA1 CCT8 CLIP1 TRIM37	1.40e-08	226	96	9	31452512
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	PIK3AP1 ATP6AP1 TTC28 ZFYVE16 CEBPZ TJP1 ITSN1 MTR PSMC4 PLPBP UGGT2 AKAP13 DICER1 NDUFS1	1.47e-08	733	96	14	34672954
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	ATP6AP1 CEBPZ SURF4 ITSN1 MTR PSMC4 TWNK UGGT2 AKAP13 ATM MAGT1 ZDHHC17 DDX21 DCTN1 PGD DICER1 NDUFS1 DCAF5 GOLGA3	2.12e-08	1487	96	19	33957083
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	EHBP1 NCOA3 TTC28 ZFYVE16 NELFCD DVL2 DVL3 CCT8 TAF1 DCTN1 GOLGA3	2.34e-08	418	96	11	34709266
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	RNF2 CEBPZ SURF4 NUMA1 RNF20 MTR CCT8 PSMC4 HAT1 PLPBP PSMD4 ATM MTREX DDX21 DCTN1 PGD DICER1 NDUFS1	6.26e-08	1425	96	18	30948266
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	SURF4 RNF20 PSMC4 UGGT2 DCTN1 CLIP1 NDUFS1 GOLGA3 IPO11	1.02e-07	285	96	9	32838362
Pubmed	CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation.	NUMA1 DVL2 DVL3	2.03e-07	5	96	3	24469800
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RNF2 STAG1 NELFCD CEBPZ TJP1 PPFIA4 ITSN1 NUMA1 ANKS1B KRT20 TWNK UGGT2 ATM ZDHHC17 DDX21 DCTN1 NDUFS1	4.03e-07	1442	96	17	35575683
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	RABL6 EHBP1 TTC28 ZFYVE16 TJP1 ITSN1 DVL2 DVL3	7.18e-07	263	96	8	34702444
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	NCOA3 ZMYND11 RNF2 NELFCD NUMA1 RNF20 CCT8 HAT1 RBM8A TAF1 ATM MTREX TBL1XR1 PGD	7.62e-07	1014	96	14	32416067
Pubmed	A human MAP kinase interactome.	EHBP1 HDAC9 ITSN1 KRT20 PSMD4 AKAP13 TAF1 ZDHHC17 DCTN1 FMNL2	9.99e-07	486	96	10	20936779
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	TTC28 SHCBP1 RNF20 CARD6 MTR UGGT2 AKAP13 MTREX ZDHHC17 DICER1 CRTC2	1.87e-06	650	96	11	38777146
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	TTC28 TJP1 DVL2 DVL3 CCT8 DCTN1 GOLGA3	2.41e-06	216	96	7	31519766
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	RABL6 CEBPZ SURF4 NUMA1 DVL2 DVL3 CCT8 PSMC4 HAT1 RBM8A MAGT1 MTREX DDX21 NDUFS1 IPO11	3.24e-06	1318	96	15	30463901
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	INTS6 NUMA1 RNF20 PSMC4 HAT1 MTREX TBL1XR1 NDUFS1 SCAF4 IPO11	3.53e-06	560	96	10	35241646
Pubmed	RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.	DVL2 MTR PSMC4 HAT1 PSMD4 MAGT1	3.63e-06	148	96	6	35676246
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	ZBTB2 TTC28 TJP1 TCEAL2 SHCBP1 PSMC4 HAT1 UGGT2 PSMD4 RBM8A PGD DICER1 NDUFS1	3.99e-06	1005	96	13	19615732
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	STAG1 CEBPZ NUMA1 RNF20 CCT8 PSMC4 HAT1 PSMD4 MTREX DCTN1 TBL1XR1	4.01e-06	704	96	11	29955894
Pubmed	Microtubules enable the planar cell polarity of airway cilia.	TJP1 DVL2 DVL3	4.40e-06	12	96	3	23122850
Pubmed	Functional proteomics mapping of a human signaling pathway.	ZMYND11 STAG1 ZFYVE16 ZNF341 NELFCD ITSN1 DVL3 TWNK DCTN1 FMNL2	5.67e-06	591	96	10	15231748
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	STAG1 ZFYVE16 ITSN1 DVL2 PLPBP PSMD4 CLIP1 PGD SCAF4	6.61e-06	472	96	9	38943005
Pubmed	Cytoplasmic localization of Nrf2 promotes colorectal cancer with more aggressive tumors via upregulation of PSMD4.	NFE2L2 PSMD4	7.54e-06	2	96	2	27033953
Pubmed	CLIP170 autoinhibition mimics intermolecular interactions with p150Glued or EB1.	DCTN1 CLIP1	7.54e-06	2	96	2	17828275
Pubmed	Genetic analysis of disheveled 2 and disheveled 3 in human neural tube defects.	DVL2 DVL3	7.54e-06	2	96	2	22892949
Pubmed	CLIP-170 interacts with dynactin complex and the APC-binding protein EB1 by different mechanisms.	DCTN1 CLIP1	7.54e-06	2	96	2	12789661
Pubmed	Up-regulation of AKAP13 and MAGT1 on cytoplasmic membrane in progressive hepatocellular carcinoma: a novel target for prognosis.	AKAP13 MAGT1	7.54e-06	2	96	2	26617690
Pubmed	Planar polarization of node cells determines the rotational axis of node cilia.	DVL2 DVL3	7.54e-06	2	96	2	20098415
Pubmed	Interaction of mammalian end binding proteins with CAP-Gly domains of CLIP-170 and p150(glued).	DCTN1 CLIP1	7.54e-06	2	96	2	22119847
Pubmed	Disheveled proteins promote cell growth and tumorigenicity in ALK-positive anaplastic large cell lymphoma.	DVL2 DVL3	7.54e-06	2	96	2	23022960
Pubmed	LncRNA SNHG12 suppresses adipocyte inflammation and insulin resistance by regulating the HDAC9/Nrf2 axis.	HDAC9 NFE2L2	7.54e-06	2	96	2	38967258
Pubmed	E3 ubiquitin ligase RNF2 interacts with the S6' proteasomal ATPase subunit and increases the ATP hydrolysis activity of S6'.	RNF2 PSMC4	7.54e-06	2	96	2	15773819
Pubmed	Microtubule plus-end loading of p150(Glued) is mediated by EB1 and CLIP-170 but is not required for intracellular membrane traffic in mammalian cells.	DCTN1 CLIP1	7.54e-06	2	96	2	16772339
Pubmed	α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons.	DCTN1 CLIP1	7.54e-06	2	96	2	26972003
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	PPP1R7 ATP6AP1 CEBPZ MTMR3 PSMC4 UGGT2 MTREX DDX21 DICER1 GOLGA3 IPO11	7.66e-06	754	96	11	33060197
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	RNF2 CEBPZ TJP1 NUMA1 DVL3 CCT8 PSMC4 PSMD4 RBM8A MTREX DDX21 DCTN1 TBL1XR1 NDUFS1	8.32e-06	1247	96	14	27684187
Pubmed	Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.	NUMA1 CCT8 PSMC4 DDX21 DCTN1 GOLGA3	8.60e-06	172	96	6	23184937
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	RABL6 DOCK9 NUMA1 PSMC4 ATM MAGT1 TTC6 SCAF4 IPO11	9.98e-06	497	96	9	36774506
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	NELFCD CCT8 PSMC4 HAT1 PSMD4 MTREX DDX21 DCTN1 NDUFS1 IPO11	1.10e-05	638	96	10	33239621
Pubmed	POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.	RNF20 ASAP3 CCT8 PSMC4 PSMD4 DCTN1 GOLGA3	1.23e-05	277	96	7	30745168
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	EHBP1 NUMA1 CCT8 TAF1 NOPCHAP1 MTREX GOLGA3 IPO11	1.31e-05	390	96	8	17643375
Pubmed	Wnts regulate planar cell polarity via heterotrimeric G protein and PI3K signaling.	TJP1 DVL2 DVL3	1.35e-05	17	96	3	32805026
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	PPP1R7 NCOA3 TJP1 ITSN1 NUMA1 DVL2 ANKS1B CCT8 DCTN1 TBL1XR1 CLIP1 GOLGA3	1.40e-05	963	96	12	28671696
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	EHBP1 ATP6AP1 TTC28 NELFCD MTMR3 MTR PSMC4 TWNK PSMD4 RBM8A MAGT1 ZDHHC17 DDX21 NDUFS1 GOLGA3	1.47e-05	1496	96	15	32877691
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	INTS6 HIP1 ATP6AP1 RNF2 FGD4 CEBPZ CCT8 TWNK RBM8A MAGT1 MTREX TBL1XR1 DICER1 NDUFS1 SCAF4	1.48e-05	1497	96	15	31527615
Pubmed	The functional interactome landscape of the human histone deacetylase family.	HDAC9 ZBTB2 STAG1 CEBPZ CCT8 TBL1XR1 DICER1	1.61e-05	289	96	7	23752268
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	EHBP1 KLF8 INTS6 HIP1 RNF2 STAG1 DICER1 SCAF4 IPO11	1.81e-05	536	96	9	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	EHBP1 KLF8 INTS6 HIP1 RNF2 STAG1 DICER1 SCAF4 IPO11	1.87e-05	538	96	9	10512203
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CEBPZ SHCBP1 NUMA1 RNF20 CCT8 PSMC4 PSMD4 AKAP13 RBM8A MTREX DDX21 DCTN1 PGD NDUFS1	2.07e-05	1353	96	14	29467282
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	SURF4 NUMA1 DVL2 DDX21 DCTN1 GOLGA3	2.14e-05	202	96	6	24639526
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	RNF2 TTC28 CEBPZ TJP1 NUMA1 CCT8 TAF1 DCTN1 SCAF4	2.19e-05	549	96	9	38280479
Pubmed	Zfp819, a novel KRAB-zinc finger protein, interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells.	KIFAP3 ZNF821	2.26e-05	3	96	2	23954693
Pubmed	Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3.	DVL2 DVL3	2.26e-05	3	96	2	18093802
Pubmed	DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway.	DVL2 DVL3	2.26e-05	3	96	2	32900645
Pubmed	Structure-function relationship of CAP-Gly domains.	DCTN1 CLIP1	2.26e-05	3	96	2	17828277
Pubmed	Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance.	NELFCD NFE2L2	2.26e-05	3	96	2	20298567
Pubmed	Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.	DVL2 DVL3	2.26e-05	3	96	2	27744318
Pubmed	Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice.	PDE6B ATM	2.26e-05	3	96	2	30345028
Pubmed	Dishevelled stability is positively regulated by PKCζ-mediated phosphorylation induced by Wnt agonists.	DVL2 DVL3	2.26e-05	3	96	2	28366812
Pubmed	Phosphorylation of EB1 regulates the recruitment of CLIP-170 and p150glued to the plus ends of astral microtubules.	DCTN1 CLIP1	2.26e-05	3	96	2	28039481
Pubmed	IL-4 induces reparative phenotype of RPE cells and protects against retinal neurodegeneration via Nrf2 activation.	PDE6B NFE2L2	2.26e-05	3	96	2	36539414
Pubmed	Amplified in breast cancer 1 enhances human cholangiocarcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 pathways.	NCOA3 NFE2L2	2.26e-05	3	96	2	22213475
Pubmed	The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2.	NFE2L2 IPO11	2.26e-05	3	96	2	25378586
Pubmed	Reconstitution of a hierarchical +TIP interaction network controlling microtubule end tracking of dynein.	DCTN1 CLIP1	2.26e-05	3	96	2	24997520
Pubmed	Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia.	DVL2 DVL3	2.26e-05	3	96	2	27086035
Pubmed	Phosphorylation of SMURF2 by ATM exerts a negative feedback control of DNA damage response.	RNF20 ATM	2.26e-05	3	96	2	33097595
Pubmed	Brain Dicer1 Is Down-Regulated in a Mouse Model of Alzheimer's Disease Via Aβ42-Induced Repression of Nuclear Factor Erythroid 2-Related Factor 2.	NFE2L2 DICER1	2.26e-05	3	96	2	32737764
Pubmed	Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling.	DVL2 DVL3	2.26e-05	3	96	2	21092292
Pubmed	Genomic organization of mouse Dishevelled genes.	DVL2 DVL3	2.26e-05	3	96	2	8973355
Pubmed	Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression.	DVL2 DVL3	2.26e-05	3	96	2	18692936
Pubmed	Polo-like kinase 1 phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase.	DCTN1 CLIP1	2.26e-05	3	96	2	20679239
Pubmed	Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma.	DVL2 DVL3	2.26e-05	3	96	2	19137009
Pubmed	The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains.	NCOA3 NFE2L2	2.26e-05	3	96	2	22370642
Pubmed	Dishevelled proteins are associated with olfactory sensory neuron presynaptic terminals.	DVL2 DVL3	2.26e-05	3	96	2	23437169
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	HIP1 TJP1 DVL2 DVL3 CCT8 PSMC4 HAT1 PSMD4 MAGT1 DDX21 DCTN1 TBL1XR1 PGD IPO11	2.32e-05	1367	96	14	32687490
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	RNF2 CEBPZ TJP1 NUMA1 CCT8 PSMC4 RBM8A MAGT1 MTREX DDX21 FMNL2 CLIP1 DICER1 SCAF4	2.39e-05	1371	96	14	36244648
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	ZMYND11 NFE2L2 ITSN1 NUMA1 ASAP3 AKAP13 ATM CRTC2	2.63e-05	430	96	8	35044719
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	RABL6 EHBP1 TTC28 ZFYVE16 SURF4 NUMA1 DVL2 CCT8 PSMC4 MAGT1	2.68e-05	708	96	10	39231216
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	ATP6AP1 RNF2 NFE2L2 MTR PSMC4 PSMD4 MTREX DCTN1 NDUFS1	2.97e-05	571	96	9	37167062
Pubmed	The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.	SURF4 CCT8 PSMC4 PSMD4 DCTN1 CLIP1 NDUFS1	3.09e-05	320	96	7	28685749
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	TTC28 TJP1 MTMR3 MTREX CLIP1 TRIM37 CRTC2 IPO11	3.40e-05	446	96	8	24255178
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	INTS6 RNF2 STAG1 CCT8 PSMC4 ATM MTREX DDX21 DCTN1	3.45e-05	582	96	9	20467437
Pubmed	Mapping the Genetic Landscape of Human Cells.	ATP6AP1 RNF20 CCT8 PSMD4 TAF1 MTREX PGD DICER1	3.68e-05	451	96	8	30033366
Pubmed	Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway.	DVL2 DVL3	4.51e-05	4	96	2	24643799
Pubmed	Pim-1 associates with protein complexes necessary for mitosis.	NUMA1 DCTN1	4.51e-05	4	96	2	12111331
Pubmed	Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein.	DVL2 DVL3	4.51e-05	4	96	2	19465938
Pubmed	DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.	DVL2 DVL3	4.51e-05	4	96	2	25557784
Pubmed	AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling.	ATM CRTC2	4.51e-05	4	96	2	20864035
Pubmed	KPNA6 (Importin {alpha}7)-mediated nuclear import of Keap1 represses the Nrf2-dependent antioxidant response.	NFE2L2 IPO11	4.51e-05	4	96	2	21383067
Pubmed	In Vitro Assay to Study Histone Ubiquitination During Transcriptional Regulation.	RNF2 TRIM37	4.51e-05	4	96	2	27832544
Pubmed	cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.	DVL2 DVL3	4.51e-05	4	96	2	8817329
Pubmed	Human dishevelled genes constitute a DHR-containing multigene family.	DVL2 DVL3	4.51e-05	4	96	2	9192851
Pubmed	LRRK1-phosphorylated CLIP-170 regulates EGFR trafficking by recruiting p150Glued to microtubule plus ends.	DCTN1 CLIP1	4.51e-05	4	96	2	25413345
Pubmed	Mouse P-selectin glycoprotein ligand-1: molecular cloning, chromosomal localization, and expression of a functional P-selectin receptor.	PDE6B GOLGA3	4.51e-05	4	96	2	8639776
Pubmed	Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways.	DVL2 DVL3	4.51e-05	4	96	2	19625296
Pubmed	Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks.	RNF20 ATM	4.51e-05	4	96	2	21362549
Pubmed	Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability.	NUMA1 ATM	4.51e-05	4	96	2	25936915
Pubmed	Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus.	DVL2 DVL3	4.51e-05	4	96	2	25043421
Interaction	RNF43 interactions	RABL6 EHBP1 TTC28 ZFYVE16 TJP1 ITSN1 DVL2 DVL3 MTR PSMC4 HAT1 PSMD4 MAGT1	9.19e-08	427	94	13	int:RNF43
Interaction	ZNF821 interactions	KIFAP3 ZNF821 DVL3 ATM	5.82e-07	15	94	4	int:ZNF821
Interaction	HDAC1 interactions	EHBP1 HDAC9 ZMYND11 ZBTB2 RNF2 STAG1 TTC28 ZFYVE16 NFE2L2 SHCBP1 RNF20 DVL2 DVL3 CCT8 TAF1 ATM DCTN1 TBL1XR1 GOLGA3	7.01e-07	1108	94	19	int:HDAC1
Interaction	DCAF15 interactions	RABL6 EHBP1 ZFYVE16 TJP1 ITSN1 NUMA1 CCT8 CLIP1 TRIM37	3.01e-06	255	94	9	int:DCAF15
Interaction	RCOR1 interactions	EHBP1 TTC28 ZFYVE16 NELFCD NUMA1 DVL2 DVL3 CCT8 TAF1 DCTN1 TBL1XR1 GOLGA3	3.18e-06	494	94	12	int:RCOR1
Interaction	PHF21A interactions	EHBP1 KLF8 RNF2 TTC28 ZFYVE16 NELFCD DVL2 DVL3 TAF1 GOLGA3	4.56e-06	343	94	10	int:PHF21A
Interaction	NCBP1 interactions	RNF2 NELFCD TJP1 NUMA1 RNF20 RBM8A MTREX ZDHHC17 DDX21 PGD	5.87e-06	353	94	10	int:NCBP1
Interaction	UBE3A interactions	NCOA3 RNF2 NELFCD CEBPZ ASAP3 DVL3 PSMC4 HAT1 PSMD4 GOLGA3 IPO11	6.57e-06	441	94	11	int:UBE3A
Interaction	RPA4 interactions	TTC28 TJP1 NUMA1 DVL2 DVL3 CCT8 HAT1 PSMD4 MAGT1 DDX21 PGD	8.29e-06	452	94	11	int:RPA4
Interaction	EED interactions	PPP1R7 HIP1 ZBTB2 RNF2 STAG1 CEBPZ TJP1 SURF4 NUMA1 CCT8 PSMC4 RBM8A MAGT1 MTREX DDX21 DCTN1 TBL1XR1 CLIP1 NDUFS1 SCAF4	9.07e-06	1445	94	20	int:EED
Interaction	SAP18 interactions	NCOA3 ZMYND11 ZBTB2 RNF2 SURF4 RBM8A TAF1 DDX21 TBL1XR1	1.28e-05	305	94	9	int:SAP18
Interaction	SMARCA5 interactions	RABL6 ZMYND11 ZBTB2 RNF2 STAG1 SHCBP1 NUMA1 ATM DDX21 GOLGA3	2.38e-05	415	94	10	int:SMARCA5
Interaction	KDM1A interactions	EHBP1 NCOA3 RNF2 TTC28 ZFYVE16 NELFCD NFE2L2 DVL2 DVL3 CCT8 TAF1 DCTN1 TBL1XR1 NDUFS1 GOLGA3	2.87e-05	941	94	15	int:KDM1A
Interaction	SMURF1 interactions	HIP1 NFE2L2 NUMA1 DVL2 CCT8 PSMC4 PSMD4 DDX21 DCTN1 TRIM37 GOLGA3	4.57e-05	544	94	11	int:SMURF1
Interaction	MTA1 interactions	ZBTB2 RNF2 STAG1 NELFCD NUMA1 HAT1 AKAP13 GOLGA3	5.37e-05	283	94	8	int:MTA1
Interaction	ATG16L1 interactions	RABL6 HIP1 TTC28 SURF4 SHCBP1 DVL2 MTR CCT8 PSMD4 AKAP13 CCDC168 ATM MTREX TRIM37 GOLGA3 IPO11	8.66e-05	1161	94	16	int:ATG16L1
Interaction	MAGOHB interactions	ZMYND11 ZBTB2 DVL2 DVL3 RBM8A DDX21	8.76e-05	155	94	6	int:MAGOHB
Interaction	CEP19 interactions	RABL6 KIFAP3 DVL2 DVL3 MTR DICER1	9.40e-05	157	94	6	int:CEP19
Interaction	SUMO2 interactions	HDAC9 KLF8 ZBTB2 NFE2L2 NUMA1 RNF20 PSMC4 RBM8A TAF1 DDX21 PGD	9.59e-05	591	94	11	int:SUMO2
Interaction	LUZP4 interactions	TJP1 DVL3 NXF2 RBM8A DDX21	1.00e-04	99	94	5	int:LUZP4
Interaction	PARP1 interactions	RABL6 HDAC9 KLF8 HIP1 RNF2 STAG1 CEBPZ SURF4 NUMA1 HAT1 RBM8A ATM MTREX DDX21 PGD STAG3 TRIM37	1.12e-04	1316	94	17	int:PARP1
Interaction	BRPF3 interactions	ZMYND11 ZBTB2 TTC28 NFE2L2 DVL2 TAF1	1.28e-04	166	94	6	int:BRPF3
Interaction	MCM7 interactions	INTS6 ZBTB2 RNF2 NELFCD NUMA1 DVL2 RBM8A DCTN1 AK8	1.36e-04	414	94	9	int:MCM7
Interaction	TRIM28 interactions	ZNF713 RNF2 ZNF33A STAG1 CEBPZ NFE2L2 NUMA1 RNF20 DVL2 CCT8 PSMC4 HAT1 PSMD4 ATM MTREX DDX21 DCTN1 TBL1XR1	1.39e-04	1474	94	18	int:TRIM28
Interaction	NXF1 interactions	RABL6 INTS6 ATP6AP1 CEBPZ SURF4 SHCBP1 NUMA1 DVL3 NXF2 MTR PSMC4 RBM8A TAF1 MAGT1 DCTN1 PGD IPO11	1.45e-04	1345	94	17	int:NXF1
Interaction	PRC1 interactions	RNF2 CEBPZ TJP1 PPFIA4 NUMA1 CCT8 KRT20 TWNK RBM8A DDX21 DCTN1 STAG3 TRIM37 NDUFS1	1.61e-04	973	94	14	int:PRC1
Interaction	SNW1 interactions	TSNAXIP1 RNF2 STAG1 DVL2 DVL3 CCT8 PSMC4 ATM MTREX ZDHHC17 DCTN1 TRIM37	1.81e-04	747	94	12	int:SNW1
Interaction	HUWE1 interactions	CYP2C9 ATP6AP1 RNF2 DVL3 MTR CCT8 PSMC4 PSMD4 ATM MTREX DDX21 DCTN1 TRIM37 NDUFS1 IPO11	1.83e-04	1110	94	15	int:HUWE1
Interaction	ETS2 interactions	NCOA3 ZMYND11 NFE2L2 DVL2	1.89e-04	61	94	4	int:ETS2
Interaction	YWHAQ interactions	NCOA3 ZBTB2 TTC28 TJP1 SHCBP1 NUMA1 RNF20 DVL2 HAT1 AKAP13 ANKRD18A MTREX PGD TRIM37 CRTC2	1.98e-04	1118	94	15	int:YWHAQ
Interaction	PRKCSH interactions	KLF8 ITSN1 RBM8A MAGT1 DDX21 DCTN1 SCAF4	2.01e-04	257	94	7	int:PRKCSH
Interaction	BBLN interactions	FGD4 RNF20 KRT20	2.10e-04	25	94	3	int:BBLN
Interaction	GBF1 interactions	RABL6 TTC28 TJP1 MROH2B DVL2 DVL3 CCT8 DCTN1 GOLGA3	2.22e-04	442	94	9	int:GBF1
Interaction	BMI1 interactions	INTS6 RNF2 NFE2L2 NUMA1 CCT8 TWNK ATM MAGT1 MTREX TBL1XR1 TRIM37	2.47e-04	659	94	11	int:BMI1
Interaction	PRPF18 interactions	NUTM1 TSNAXIP1 CADPS DVL3 FMNL2	2.48e-04	120	94	5	int:PRPF18
Interaction	H1-2 interactions	EHBP1 ZBTB2 RNF2 NELFCD CEBPZ RNF20 NXF2 ATM DDX21 DCTN1 TRIM37	2.71e-04	666	94	11	int:H1-2
Interaction	RSF1 interactions	ZBTB2 RNF2 SHCBP1 NUMA1 ATM	2.88e-04	124	94	5	int:RSF1
Interaction	CPZ interactions	TJP1 DVL2 DVL3	2.96e-04	28	94	3	int:CPZ
Interaction	AATK interactions	RABL6 EHBP1 PPP1R7 ZFYVE16 ITSN1 DCTN1	2.97e-04	194	94	6	int:AATK
Interaction	SH2D4A interactions	NUTM1 PPP1R7 ZBTB2 CADPS DVL2	2.99e-04	125	94	5	int:SH2D4A
Interaction	EGLN3 interactions	ZFYVE16 DVL2 MTMR3 DVL3 MTR CCT8 PSMC4 HAT1 PSMD4 AKAP13 DCTN1 TBL1XR1 DICER1 TRIM37 NDUFS1 CRTC2	3.05e-04	1296	94	16	int:EGLN3
Interaction	NUP214 interactions	HDAC9 ITSN1 NUMA1 DVL2 NXF2 CLIP1	3.05e-04	195	94	6	int:NUP214
Interaction	MOV10 interactions	RABL6 INTS6 ZBTB2 ATP6AP1 RNF2 SURF4 NUMA1 NXF2 MTR PSMC4 TAF1 MAGT1 DDX21 DCTN1 PGD DICER1	3.08e-04	1297	94	16	int:MOV10
Interaction	EIF6 interactions	HDAC9 HIP1 ZBTB2 RNF2 CEBPZ CCT8 RBM8A DICER1	3.08e-04	365	94	8	int:EIF6
Interaction	COPB2 interactions	ZBTB2 ATP6AP1 RNF2 NELFCD TJP1 SURF4 HAT1 TRIM37	3.37e-04	370	94	8	int:COPB2
Interaction	DAAM1 interactions	PDE6B FGD4 DVL2 FMNL2	3.58e-04	72	94	4	int:DAAM1
Interaction	NEK4 interactions	KCNH7 TTC28 CADPS MTMR3 MTR HAT1 C4BPB DDX21 PGD NDUFS1	3.83e-04	582	94	10	int:NEK4
Interaction	CDC42 interactions	RABL6 EHBP1 ATP6AP1 FGD4 CEBPZ TJP1 DOCK9 ITSN1 RBM8A MAGT1 FMNL2 CLIP1 PGD TRIM37 NDUFS1 IPO11	3.84e-04	1323	94	16	int:CDC42
Interaction	UBE2E3 interactions	RNF2 NFE2L2 TBL1XR1 TRIM37 IPO11	3.85e-04	132	94	5	int:UBE2E3
Interaction	BAZ1B interactions	KLF8 ZBTB2 RNF2 NUMA1 ATM DDX21	3.88e-04	204	94	6	int:BAZ1B
Interaction	SUMO1 interactions	HDAC9 NCOA3 ZBTB2 TJP1 NFE2L2 NUMA1 SCAF4	3.93e-04	287	94	7	int:SUMO1
Interaction	ALOX5 interactions	NUTM1 ITSN1 MTMR3 DICER1	3.98e-04	74	94	4	int:ALOX5
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	NCOA3 HAT1 TAF1	3.96e-05	17	72	3	486
GeneFamily	Dishevelled segment polarity proteins\|PDZ domain containing	DVL2 DVL3	9.34e-05	4	72	2	505
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	FGD4 CADPS DOCK9 ITSN1 ASAP3 AKAP13	1.70e-04	206	72	6	682
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	ZFYVE16 FGD4 MTMR3	2.51e-04	31	72	3	81
GeneFamily	Ankyrin repeat domain containing	ASAP3 ANKS1B ANKRD18A ZDHHC17 ANKFN1 ANKRD18B	4.04e-04	242	72	6	403
GeneFamily	Cohesin complex	STAG1 STAG3	4.31e-04	8	72	2	1060
GeneFamily	X-linked mental retardation\|RNA helicases	MTREX DICER1	8.40e-04	11	72	2	1168
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	FGD4 ITSN1 AKAP13	2.32e-03	66	72	3	722
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	EHBP1 KIFAP3 NCOA3 ZMYND11 RNF2 STAG1 TTC28 ZFYVE16 DOCK9 ITSN1 MTMR3 MTR HAT1 AKAP13 MTREX ZDHHC17 DDX21 CLIP1 DICER1 TRIM37	3.19e-11	856	96	20	M4500
Coexpression	ANDERSON_BLOOD_CN54GP140_ADJUVANTED_WITH_GLA_AF_AGE_18_45YO_1DY_DN	ATP6AP1 ZNF341 MTMR3 DVL3 PGD	1.54e-05	85	96	5	M41085
Coexpression	KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP	HDAC9 NCOA3 HIP1 RNF2 UGGT2 AKAP13 DDX21 FMNL2 CLIP1 PGD DCAF5 CRTC2 SCAF4	3.93e-05	942	96	13	M8144
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	EHBP1 NCOA3 ZMYND11 STAG1 ITSN1 MTREX ZDHHC17 CLIP1 TRIM37	5.43e-05	466	96	9	M13522
Coexpression	ENK_UV_RESPONSE_KERATINOCYTE_DN	KIFAP3 NCOA3 ZMYND11 RNF2 ITSN1 MTMR3 RBM8A CLIP1 NDUFS1	6.92e-05	481	96	9	M3898
Coexpression	GSE22886_UNSTIM_VS_IL2_STIM_NKCELL_UP	ZFYVE16 LRRC37A3 NUMA1 MTMR3 AKAP13 ATM	8.59e-05	196	96	6	M4530
Coexpression	GSE13411_IGM_VS_SWITCHED_MEMORY_BCELL_DN	ATP6AP1 MTMR3 PLPBP DICER1 NDUFS1 SCAF4	9.08e-05	198	96	6	M3248
Coexpression	GSE22886_NAIVE_TCELL_VS_NKCELL_DN	KIFAP3 INTS6 ZFYVE16 MTMR3 DVL3 ZDHHC17	9.08e-05	198	96	6	M4415
Coexpression	GSE13493_DP_VS_CD4INTCD8POS_THYMOCYTE_DN	CADPS CARD6 CCT8 DDX21 CLIP1 NDUFS1	9.34e-05	199	96	6	M3313
Coexpression	HALLMARK_MITOTIC_SPINDLE	KIFAP3 FGD4 ITSN1 NUMA1 AKAP13 CLIP1	9.34e-05	199	96	6	M5893
Coexpression	GSE8835_CD4_VS_CD8_TCELL_UP	ZMYND11 NUMA1 DVL2 MTR FAM216A TAF1	9.60e-05	200	96	6	M6254
Coexpression	GSE23321_CENTRAL_VS_EFFECTOR_MEMORY_CD8_TCELL_DN	EHBP1 FGD4 SURF4 NUMA1 CTSV IPO11	9.60e-05	200	96	6	M8434
Coexpression	GSE43863_TFH_VS_LY6C_INT_CXCR5POS_EFFECTOR_CD4_TCELL_UP	PPP1R7 RNF2 NFE2L2 PLPBP RBM8A CTSV	9.60e-05	200	96	6	M9770
Coexpression	NAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_3DY_UP	PIK3AP1 PPP1R7 INTS6 FGD4 RNF20 PLPBP PSMD4 FMNL2 DICER1 NDUFS1	9.90e-05	625	96	10	M41067
Coexpression	KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP	HDAC9 NCOA3 HIP1 RNF2 UGGT2 AKAP13 CLIP1 PGD DCAF5 CRTC2 SCAF4	1.31e-04	778	96	11	M17915
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLF8 PPFIA4 RNF20 CARD6 MTR FMNL2 AK8	1.11e-07	176	96	7	6b4afd2c9268172063fe5832896bea15e862579e
ToppCell	3'-Child09-12-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KLF8 HIP1 TTC28 DOCK9 CARD6 IPO11	2.95e-06	184	96	6	842473fa415575441b595073a994b6d621169776
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	STAG1 TTC28 LRRC37A3 FGD4 TBL1XR1 FMNL2	4.62e-06	199	96	6	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
Drug	Benfotiamine [22457-89-2]; Down 200; 8.6uM; PC3; HT_HG-U133A	RABL6 EHBP1 NUMA1 AKAP13 ATM ZDHHC17 DICER1 STAG3	1.55e-06	194	95	8	4312_DN
Drug	Droperidol [548-73-2]; Down 200; 10.6uM; PC3; HT_HG-U133A	RABL6 TSNAXIP1 PPFIA4 NUMA1 DVL2 ASAP3 KRT20 SCAF4	1.68e-06	196	95	8	4629_DN
Drug	irinotecan HCl; Down 200; 100uM; MCF7; HT_HG-U133A	EHBP1 NCOA3 STAG1 TJP1 NFE2L2 AKAP13 ZDHHC17	1.18e-05	183	95	7	7498_DN
Drug	Corynanthine hydrochloride [66634-44-4]; Down 200; 10.2uM; MCF7; HT_HG-U133A	EHBP1 ZNF821 DVL3 UGGT2 AKAP13 STAG3 SCAF4	1.55e-05	191	95	7	4811_DN
Drug	Bendroflumethiazide [73-48-3]; Down 200; 9.4uM; MCF7; HT_HG-U133A	SLC7A8 ZNF821 HIP1 TTC28 NUMA1 ASAP3 ZDHHC17	1.72e-05	194	95	7	3840_DN
Drug	sodium 4-phenylbutyrate; Up 200; 1000uM; HL60; HG-U133A	SLC7A8 PPP1R7 KIFAP3 NCOA3 ZNF821 ITSN1 MTMR3	1.83e-05	196	95	7	411_UP
Drug	Pempidine tartrate [546-48-5]; Down 200; 13uM; MCF7; HT_HG-U133A	ZNF821 HIP1 ZFYVE16 ITSN1 DVL3 PLPBP SCAF4	1.96e-05	198	95	7	6027_DN
Disease	Moyamoya disease	HDAC9 DOCK9 FMNL2	2.75e-04	40	93	3	MONDO_0016820
Disease	complement component C7 measurement	MROH2B CARD6	6.35e-04	12	93	2	EFO_0008093
Disease	Gastrointestinal Diseases	NFE2L2 MTR	6.35e-04	12	93	2	C0017178
Disease	Functional Gastrointestinal Disorders	NFE2L2 MTR	6.35e-04	12	93	2	C0559031
Disease	Cholera Infantum	NFE2L2 MTR	6.35e-04	12	93	2	C1565321
Disease	Prostatic Neoplasms	EHBP1 NCOA3 NFE2L2 SURF4 ITSN1 AKAP13 ATM TBL1XR1	7.41e-04	616	93	8	C0033578
Disease	Malignant neoplasm of prostate	EHBP1 NCOA3 NFE2L2 SURF4 ITSN1 AKAP13 ATM TBL1XR1	7.41e-04	616	93	8	C0376358
Disease	biological sex	TTC28 CADPS ITSN1 CLIP1 AK8	8.20e-04	230	93	5	PATO_0000047
Disease	Lymphoma, Large-Cell, Follicular	ATP6AP1 MTR	1.00e-03	15	93	2	C0079745
Disease	Lymphoma, Small Cleaved-Cell, Follicular	ATP6AP1 MTR	1.00e-03	15	93	2	C0079765
Disease	Lymphoma, Mixed-Cell, Follicular	ATP6AP1 MTR	1.00e-03	15	93	2	C0079758
Disease	Neoplasm of uncertain or unknown behavior of bladder	ATM TBL1XR1	1.00e-03	15	93	2	C0496930
Disease	Lymphoma, Follicular, Grade 2	ATP6AP1 MTR	1.00e-03	15	93	2	C1956132
Disease	Lymphoma, Follicular, Grade 3	ATP6AP1 MTR	1.00e-03	15	93	2	C1956131
Disease	Lymphoma, Follicular, Grade 1	ATP6AP1 MTR	1.00e-03	15	93	2	C1956130
Disease	Benign neoplasm of bladder	ATM TBL1XR1	1.00e-03	15	93	2	C0154017
Disease	Carcinoma in situ of bladder	ATM TBL1XR1	1.00e-03	15	93	2	C0154091
Disease	Carcinoma of bladder	ATM TBL1XR1	1.45e-03	18	93	2	C0699885
Disease	colorectal cancer (is_marker_for)	ASAP3 KRT20 ATM DICER1	1.56e-03	157	93	4	DOID:9256 (is_marker_for)
Disease	Lymphoma, Follicular	ATP6AP1 MTR	1.80e-03	20	93	2	C0024301
Disease	Ovarian Failure, Premature	NFE2L2 STAG3	1.98e-03	21	93	2	C0085215
Disease	serum gamma-glutamyl transferase measurement	PIK3AP1 EHBP1 STAG1 TJP1 ASAP3 TWNK AKAP13 G6PC1 DCAF5	2.38e-03	914	93	9	EFO_0004532
Disease	Drug toxicity	CYP2C9 NFE2L2 MTR	2.40e-03	84	93	3	C0013221
Disease	Adverse reaction to drug	CYP2C9 NFE2L2 MTR	2.40e-03	84	93	3	C0041755
Disease	Charcot-Marie-Tooth disease (implicated_via_orthology)	FGD4 MTMR3	2.59e-03	24	93	2	DOID:10595 (implicated_via_orthology)
Disease	paracentral lobule volume measurement	DOCK9 CARD6	2.81e-03	25	93	2	EFO_0010317

Protein segments in the cluster

Peptide	Gene	Start	Entry
NMGNTSFNEVMEAQL	ASAP3	496	Q8TDY4
LEMTINMLNAFANED	ANKRD18A	711	Q8IVF6
EMDVTGQAFEDMQEQ	RNF20	731	Q5VTR2
GQAFEDMQEQNIRLM	RNF20	736	Q5VTR2
VGDLEAMNEMNDELQ	DCTN1	461	Q14203
AMNAFGDMTNEEFRQ	CTSV	76	O60911
SQGMMADLLFEQQMV	AKAP13	2021	Q12802
EMTINMLNAFANEDF	ANKRD18B	721	A2A2Z9
KDVLGMAQDEMAQAF	PGD	206	P52209
DFVQFQLEKNEMQGM	DICER1	1771	Q9UPY3
GDMLLQVNEINFENM	DVL3	296	Q92997
LFGINQLEEEDMMTN	PIK3AP1	316	Q6ZUJ8
NDMNFENMSNDDAVR	DVL2	321	O14641
EAQAAMEGLNGQDLM	RBM8A	126	Q9Y5S9
QETEDQNYGIFLEMM	RABL6	261	Q3YEC7
MMIDEADEFVAGPQN	INTS6	626	Q9UL03
EANEDMEEQQQPMYQ	SLC7A8	506	Q9UHI5
DDMFVTFAAMQAQQG	MCOLN1	471	Q9GZU1
FDNVQFMGSNVMEDQ	ANKS1B	836	Q7Z6G8
GETQIMADEAFMNAV	CADPS	166	Q9ULU8
AFEENVFMENTNMPE	LRRC37A3	1396	O60309
FDEGSDVFQMLNMNS	MAGT1	121	Q9H0U3
AQAMMSVLAQEEQGG	NELFCD	241	Q8IXH7
KNQEGVAMMFIINFE	KCNH7	116	Q9NS40
DADANFEQLMVNMLD	PPFIA4	21	O75335
KFNQEMDQLLGNMIE	IPO11	816	Q9UI26
QYGEENHIFELMQNM	AK8	16	Q96MA6
NIMNASADEMFKFQE	PDE6B	356	P35913
FNEMMSKEQFNEAQL	NFE2L2	481	Q16236
NGVMAAQNQMECEEE	FGD4	91	Q96M96
NELLDMFMAVQALNG	GUCA1C	111	O95843
NQSVQEDPRMMAFFD	DCAF5	406	Q96JK2
QQEPAAMAQMQGEES	KLF8	251	O95600
DNLQFMMGHEQLSTD	TWNK	516	Q96RR1
EADMLDQEAAFMQIQ	GOLGA3	646	Q08378
FVGNEKMAMQNLNDR	KRT20	66	P35900
FMEFEAEEMQIQNTQ	NUTM1	286	Q86Y26
LMEVEDQSSMNLFND	ATM	846	Q13315
MQGFNEDMVIEAQQK	HAT1	306	O14929
NMEGLQAALQEVMFS	CARD6	621	Q9BX69
DVGMQDVHFNEDVLM	DOCK9	1701	Q9BZ29
MEEGMNVLHDFGIQS	G6PC1	1	P35575
MSDFNLGNLEQFSME	CRTC2	551	Q53ET0
DMNNDGRMDQVEFSI	ITSN1	66	Q15811
CEAMENFMQQLKESG	C4BPB	216	P20851
DNNIDFMVASMQFIN	FMNL2	311	Q96PY5
MSMKQADIGNLDDFE	EHBP1	176	Q8NDI1
FQFNASMQQEKLDAM	CCDC168	3336	Q8NDH2
HQESMDMNNPQDFID	CYP2C9	251	P11712
QEMESGEQAAFMQQP	HDAC9	561	Q9UKV0
VDQMLDMGFADQVEE	DDX21	341	Q9NR30
NFMQSMSIEEQGEHL	FAM216A	256	Q8WUB2
GAGQQQSQEMMEVDR	PPP1R7	6	Q15435
MQMSLQGAEFGQAES	PSMD4	291	P55036
MDAVNAFNQELFSLM	SCAF4	1	O95104
ELDNNNAAMAIDPVM	RNF2	206	Q99496
MMSEAALNGNGDDLN	CLIP1	1346	P30622
LDENMGSKFDNIGMN	CEBPZ	986	Q03701
FEGMEIDEVANINDM	KIFAP3	121	Q92845
FKNEVERMGFDMNNA	MTMR3	161	Q13615
ALQAMEREAEQMGNE	NUMA1	966	Q14980
EQQEMVQAFSAQSGM	NXF2	571	Q9GZY0
MSGENDVEYNNMELE	TRIM37	556	O94972
MDGFDQNVNVKVIMA	PSMC4	296	P43686
ECDLQDQSMMFGNDR	NDUFS1	136	P28331
DFEEMGKNIENMLQN	TAF1	1096	P21675
DLMDMDASQQNLFDN	HIP1	331	O00291
VEMGAQVLDVNMDDG	MTR	406	Q99707
KQDAFQGQEAAVMMD	NCOA3	1091	Q9Y6Q9
MGQNDLMGTAEDFAD	SURF4	1	O15260
ADDNLMSQEMFVGIV	SHCBP1	641	Q8NEM2
VNAEDCQEMFNLLQM	MROH2B	881	Q7Z745
IQMDVALFEMNQSDS	NOPCHAP1	111	Q8N5I9
ADQVELSMGMSADFQ	PLPBP	216	O94903
IANNHTDMMEVDGDV	TBL1XR1	141	Q9BZK7
QGNEAMFEAVEQQDM	ANKFN1	136	Q8N957
MAQAIFEALEGMDNQ	ZNF341	1	Q9BYN7
LQMGNNFAAMQDINA	TTC6	326	Q86TZ1
MMFNGLFNDLSAEQA	MTREX	891	P42285
QEHQEEIEGMMNALF	STAG3	291	Q9UJ98
QDEIENMMNSIFKGI	STAG1	281	Q8WVM7
NFSNEDMIREFDNMA	TCEAL2	161	Q9H3H9
PQSMFIQEGEDVSMN	TRAV35	26	P0DPF4
MLQDFQIQAFNVMGE	ATP6AP1	396	Q15904
LIAKGQDVDMMDQNG	ZDHHC17	176	Q8IUH5
IGENLMNEMDIRNFQ	ZNF33A	771	Q06730
ENDRVAMVNGVSMDN	TJP1	71	Q07157
EAGDIMDQQFEEMNN	TTC28	1321	Q96AY4
QAVNKAVANMQGEMD	ZMYND11	511	Q15326
QVFAGLEEQARQAMM	ZNF821	16	O75541
FEEGSQMDNMLVQTN	ZBTB2	431	Q8N680
AVFSQEGNMEEEEMN	ZNF713	6	Q8N859
VENMGINANNMSDFI	UGGT2	911	Q9NYU1
TQMELNNMKANFGDV	TSNAXIP1	241	Q2TAA8
MNFSKGEENLMDAQV	CCT8	266	P50990
MNQIDMKGLDDGNIN	ZFYVE16	561	Q7Z3T8
NMAQDKVAQLQVEMG	KEL	466	P23276