Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	FGFR1 FGFR3 TEK PTK7	1.16e-04	65	77	4	GO:0004714
GeneOntologyMolecularFunction	fibroblast growth factor receptor activity	FGFR1 FGFR3	1.46e-04	5	77	2	GO:0005007
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	FGFR1 FGFR3 TEK PTK7	3.27e-04	85	77	4	GO:0019199
HumanPheno	Cloverleaf skull	FGFR1 FGFR3 EXTL3	3.34e-06	8	21	3	HP:0002676
HumanPheno	Protuberant abdomen	DUX4 FGFR3 BMPER KIAA0753	3.40e-05	47	21	4	HP:0001538
HumanPheno	Trident hand	FGFR3 EXTL3	4.84e-05	3	21	2	HP:0004060
HumanPheno	Skeletal dysplasia	MBTPS1 TMEM53 FGFR1 FGFR3 EXTL3 KIAA0753	7.50e-05	186	21	6	HP:0002652
HumanPheno	Abnormal fetal skeletal morphology	FGFR3 BMPER	9.67e-05	4	21	2	HP:0025662
HumanPheno	Short middle phalanx of toe	FGFR1 FGFR3	1.61e-04	5	21	2	HP:0003795
HumanPheno	Broad ischia	TMEM53 EXTL3	1.61e-04	5	21	2	HP:0100865
HumanPheno	Disproportionate short stature	FGFR1 FGFR3 BMPER EXTL3 KIAA0753	1.88e-04	137	21	5	HP:0003498
Domain	FGF_rcpt_fam	FGFR1 FGFR3	9.50e-05	4	75	2	IPR016248
Domain	Sulfotransferase_dom	CHST15 SULT1C2 DSEL	4.04e-04	36	75	3	IPR000863
Domain	Sulfotransfer_1	CHST15 SULT1C2 DSEL	4.04e-04	36	75	3	PF00685
Domain	TyrKc	FGFR1 FGFR3 TEK PTK7	4.33e-04	88	75	4	SM00219
Domain	Tyr_kinase_cat_dom	FGFR1 FGFR3 TEK PTK7	4.33e-04	88	75	4	IPR020635
Domain	PROTEIN_KINASE_TYR	FGFR1 FGFR3 TEK PTK7	6.27e-04	97	75	4	PS00109
Domain	Tyr_kinase_AS	FGFR1 FGFR3 TEK PTK7	6.27e-04	97	75	4	IPR008266
Domain	Pkinase_Tyr	FGFR1 FGFR3 TEK PTK7	1.81e-03	129	75	4	PF07714
Domain	Ser-Thr/Tyr_kinase_cat_dom	FGFR1 FGFR3 TEK PTK7	2.31e-03	138	75	4	IPR001245
Domain	GPCR_3	TAS1R3 GPR156	3.18e-03	21	75	2	IPR000337
Domain	7tm_3	TAS1R3 GPR156	3.49e-03	22	75	2	PF00003
Domain	G_PROTEIN_RECEP_F3_2	TAS1R3 GPR156	3.49e-03	22	75	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	TAS1R3 GPR156	3.49e-03	22	75	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	TAS1R3 GPR156	3.49e-03	22	75	2	PS00979
Domain	G_PROTEIN_RECEP_F3_4	TAS1R3 GPR156	3.49e-03	22	75	2	PS50259
Domain	GPCR_3_C	TAS1R3 GPR156	3.49e-03	22	75	2	IPR017978
Domain	IG_LIKE	TREML4 FGFR1 FGFR3 NECTIN3 ROBO3 TEK PTK7	3.54e-03	491	75	7	PS50835
Domain	Ig-like_dom	TREML4 FGFR1 FGFR3 NECTIN3 ROBO3 TEK PTK7	4.04e-03	503	75	7	IPR007110
Domain	C_TYPE_LECTIN_1	SELP ATRN LY75	4.09e-03	80	75	3	PS00615
Domain	Lectin_C	SELP ATRN LY75	4.69e-03	84	75	3	PF00059
Domain	CLECT	SELP ATRN LY75	4.69e-03	84	75	3	SM00034
Domain	C_TYPE_LECTIN_2	SELP ATRN LY75	4.85e-03	85	75	3	PS50041
Domain	C-type_lectin-like	SELP ATRN LY75	5.01e-03	86	75	3	IPR001304
Domain	-	TREML4 PTPRG FGFR1 FGFR3 NECTIN3 ROBO3 TEK PTK7	5.03e-03	663	75	8	2.60.40.10
Pubmed	The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L7	4.96e-15	8	85	6	17588759
Pubmed	DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L7	3.71e-14	10	85	6	17984056
Pubmed	Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L7	1.63e-13	12	85	6	10433963
Pubmed	Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L7	3.01e-13	13	85	6	17668377
Pubmed	Characterization of a tandemly repeated 3.3-kb KpnI unit in the facioscapulohumeral muscular dystrophy (FSHD) gene region on chromosome 4q35.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L7	3.01e-13	13	85	6	7739628
Pubmed	Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L7	2.16e-12	17	85	6	11245978
Pubmed	Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.	FGFR1 FGFR3 TEK PTK7	2.84e-06	40	85	4	30898150
Pubmed	Molecular genetics of successful smoking cessation: convergent genome-wide association study results.	ITGA11 SEMA5A CSMD1 TEK SORCS1	5.10e-06	101	85	5	18519826
Pubmed	Clathrin- and dynamin-independent endocytosis of FGFR3--implications for signalling.	FGFR1 FGFR3	5.90e-06	2	85	2	21779335
Pubmed	Fibroblast growth factor receptor 1 and 3 expression is associated with regulatory PI3K/AKT kinase activity, as well as invasion and prognosis, in human laryngeal cancer.	FGFR1 FGFR3	5.90e-06	2	85	2	29299828
Pubmed	Transiently, paralleled upregulation of arginase and nitric oxide synthase and the effect of both enzymes on the pathology of asthma.	ARG2 NOS2	5.90e-06	2	85	2	17890324
Pubmed	siRNA mediated knockdown of fibroblast growth factor receptors 1 or 3 inhibits FGF-induced anchorage-independent clonogenicity but does not affect MAPK activation.	FGFR1 FGFR3	5.90e-06	2	85	2	16685373
Pubmed	Arginine metabolic control of airway inflammation.	ARG2 NOS2	5.90e-06	2	85	2	31996482
Pubmed	Oncogene mutation profiling reveals poor prognosis associated with FGFR1/3 mutation in liposarcoma.	FGFR1 FGFR3	5.90e-06	2	85	2	27237367
Pubmed	Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3.	FGFR1 FGFR3	5.90e-06	2	85	2	1379594
Pubmed	Fibroblast growth factor receptors-1 and -3 play distinct roles in the regulation of bladder cancer growth and metastasis: implications for therapeutic targeting.	FGFR1 FGFR3	5.90e-06	2	85	2	23468956
Pubmed	Reciprocal relationship in gene expression between FGFR1 and FGFR3: implication for tumorigenesis.	FGFR1 FGFR3	5.90e-06	2	85	2	15558020
Pubmed	Clinical association analysis of ependymomas and pilocytic astrocytomas reveals elevated FGFR3 and FGFR1 expression in aggressive ependymomas.	FGFR1 FGFR3	5.90e-06	2	85	2	28468611
Pubmed	Secreted FGFR3, but not FGFR1, inhibits lens fiber differentiation.	FGFR1 FGFR3	5.90e-06	2	85	2	11290300
Pubmed	Catalytically inactive receptor tyrosine kinase PTK7 activates FGFR1 independent of FGF.	FGFR1 PTK7	5.90e-06	2	85	2	31490704
Pubmed	Differential regulation of endochondral bone growth and joint development by FGFR1 and FGFR3 tyrosine kinase domains.	FGFR1 FGFR3	5.90e-06	2	85	2	11585811
Pubmed	Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection.	ARG2 NOS2	5.90e-06	2	85	2	27074721
Pubmed	Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors.	PTPRG FGFR1	5.90e-06	2	85	2	29371290
Pubmed	RAS-MAPK Reactivation Facilitates Acquired Resistance in FGFR1-Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR-MEK Blockade.	FGFR1 FGFR3	5.90e-06	2	85	2	29654068
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	ATRN OLFML2A EDEM3 MBTPS1 ITGA11 SVIL NECTIN3 BMPER EXTL3 PRSS23 LMBRD2 DSEL PTK7	6.85e-06	1201	85	13	35696571
Pubmed	A genomic atlas of mouse hypothalamic development.	SEMA5A SOX14 FGFR1 NECTIN3 BMPER ROBO3	1.16e-05	205	85	6	20436479
Pubmed	Transient Redirection of SVZ Stem Cells to Oligodendrogenesis by FGFR3 Activation Promotes Remyelination.	FGFR1 FGFR3	1.77e-05	3	85	2	31189094
Pubmed	Isolation of the complementary DNA encoding a mouse heparin-binding growth factor receptor with the use of a unique kinase insert sequence.	FGFR1 FGFR3	1.77e-05	3	85	2	8382556
Pubmed	Expression of fibroblast growth factor receptor1, -2c, and -3c transcripts in mouse molars after tooth eruption.	FGFR1 FGFR3	1.77e-05	3	85	2	33433858
Pubmed	Fibroblast growth factor receptor signaling in pediatric B-cell precursor acute lymphoblastic leukemia.	FGFR1 FGFR3	1.77e-05	3	85	2	30755670
Pubmed	Expression of fibroblast growth factor receptors (FGFR1, FGFR2, FGFR3) in the developing head and face.	FGFR1 FGFR3	1.77e-05	3	85	2	9286594
Pubmed	Fibroblast growth factor (FGF) 3 from Xenopus laevis (XFGF3) binds with high affinity to FGF receptor 2.	FGFR1 FGFR3	1.77e-05	3	85	2	7896824
Pubmed	Differential roles of fibroblast growth factor receptors (FGFR) 1, 2 and 3 in the regulation of S115 breast cancer cell growth.	FGFR1 FGFR3	1.77e-05	3	85	2	23185502
Pubmed	FGF-FGFR Mediates the Activity-Dependent Dendritogenesis of Layer IV Neurons during Barrel Formation.	FGFR1 FGFR3	1.77e-05	3	85	2	29097598
Pubmed	Fibroblast growth factor receptors in in vitro and in vivo chondrogenesis: relating tissue engineering using adult mesenchymal stem cells to embryonic development.	FGFR1 FGFR3	1.77e-05	3	85	2	19728793
Pubmed	Genome-wide open reading frame profiling identifies fibroblast growth factor signaling as a driver of PD-L1 expression in head and neck squamous cell carcinoma.	FGFR1 FGFR3	1.77e-05	3	85	2	37666053
Pubmed	Enriched Environment Promotes Adult Hippocampal Neurogenesis through FGFRs.	FGFR1 FGFR3	1.77e-05	3	85	2	33637561
Pubmed	Complete inhibition of goiter in mice requires combined gene therapy modification of angiopoietin, vascular endothelial growth factor, and fibroblast growth factor signaling.	FGFR1 TEK	1.77e-05	3	85	2	15817662
Pubmed	Fibroblast growth factor receptor (FGFR) gene amplifications are rare events in bladder cancer.	FGFR1 FGFR3	1.77e-05	3	85	2	24898159
Pubmed	FGFR mutations and plagiocephaly.	FGFR1 FGFR3	1.77e-05	3	85	2	18216705
Pubmed	Differential fibroblast growth factor 8 (FGF8)-mediated autoregulation of its cognate receptors, Fgfr1 and Fgfr3, in neuronal cell lines.	FGFR1 FGFR3	1.77e-05	3	85	2	20405041
Pubmed	FGFR Craniosynostosis Syndromes Overview	FGFR1 FGFR3	1.77e-05	3	85	2	20301628
Pubmed	Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin.	ARG2 NOS2	1.77e-05	3	85	2	19027033
Pubmed	NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins.	CHAF1A DUX4	1.77e-05	3	85	2	29533181
Pubmed	Rotavirus inhibits IFN-induced STAT nuclear translocation by a mechanism that acts after STAT binding to importin-α.	STAT2 KPNA2	1.77e-05	3	85	2	24814927
Pubmed	Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes.	FGFR1 FGFR3	1.77e-05	3	85	2	31830366
Pubmed	Cell-free mRNA concentrations of CRH, PLAC1, and selectin-P are increased in the plasma of pregnant women with preeclampsia.	SELP PLAC1	1.77e-05	3	85	2	17554801
Pubmed	FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer.	FGFR1 FGFR3	1.77e-05	3	85	2	24850843
Pubmed	Compound deficiencies in multiple fibroblast growth factor signalling components differentially impact the murine gonadotrophin-releasing hormone system.	FGFR1 FGFR3	1.77e-05	3	85	2	20553372
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CUL3 KDM3A SLC41A3 LMO7 CHAF1A SVIL ZNF516 PHACTR4 SEMA5A SNX33	1.96e-05	774	85	10	15302935
Pubmed	Par3 is essential for the establishment of planar cell polarity of inner ear hair cells.	TIAM1 NECTIN3 PTK7	2.75e-05	24	85	3	30814219
Pubmed	Transforming fusions of FGFR and TACC genes in human glioblastoma.	FGFR1 FGFR3	3.53e-05	4	85	2	22837387
Pubmed	Somatic FGFR and TWIST mutations are not a common cause of isolated nonsyndromic single suture craniosynostosis.	FGFR1 FGFR3	3.53e-05	4	85	2	17414280
Pubmed	Responsiveness of developing dental tissues to fibroblast growth factors: expression of splicing alternatives of FGFR1, -2, -3, and of FGFR4; and stimulation of cell proliferation by FGF-2, -4, -8, and -9.	FGFR1 FGFR3	3.53e-05	4	85	2	9664689
Pubmed	Isolated sagittal and coronal craniosynostosis associated with TWIST box mutations.	FGFR1 FGFR3	3.53e-05	4	85	2	17343269
Pubmed	MKP-1 switches arginine metabolism from nitric oxide synthase to arginase following endotoxin challenge.	ARG2 NOS2	3.53e-05	4	85	2	17442735
Pubmed	Expression patterns of Twist and Fgfr1, -2 and -3 in the developing mouse coronal suture suggest a key role for twist in suture initiation and biogenesis.	FGFR1 FGFR3	3.53e-05	4	85	2	10704861
Pubmed	Differential expression of the fibroblast growth factor receptor (FGFR) multigene family in normal human adult tissues.	FGFR1 FGFR3	3.53e-05	4	85	2	9212826
Pubmed	Expression of fibroblast growth factor receptor family members is associated with prognosis in early stage cervical cancer patients.	FGFR1 FGFR3	3.53e-05	4	85	2	27154171
Pubmed	Astrocyte activation is suppressed in both normal and injured brain by FGF signaling.	FGFR1 FGFR3	3.53e-05	4	85	2	25002516
Pubmed	Immunolocalization of fibroblast growth factor receptors in normal and wounded human skin.	FGFR1 FGFR3	3.53e-05	4	85	2	12373339
Pubmed	FGFR1-4 RNA-Based Gene Alteration and Expression Analysis in Squamous Non-Small Cell Lung Cancer.	FGFR1 FGFR3	3.53e-05	4	85	2	36142417
Pubmed	Immunohistochemical detection of fibroblast growth factor receptors in normal endocrine cells and related tumors of the digestive system.	FGFR1 FGFR3	3.53e-05	4	85	2	11759058
Pubmed	Lens fiber cell differentiation occurs independently of fibroblast growth factor receptor signaling in the absence of Pten.	FGFR1 FGFR3	3.53e-05	4	85	2	32858001
Pubmed	The FGF system has a key role in regulating vascular integrity.	FGFR1 FGFR3	3.53e-05	4	85	2	18776942
Pubmed	RNAi-based conditional gene knockdown in mice using a U6 promoter driven vector.	FGFR1 FGFR3	3.53e-05	4	85	2	17304337
Pubmed	Differential expression of fibroblast growth factor receptors in the developing murine choroid plexus.	FGFR1 FGFR3	3.53e-05	4	85	2	12644244
Pubmed	Extracellular signal-regulated kinase mediates expression of arginase II but not inducible nitric-oxide synthase in lipopolysaccharide-stimulated macrophages.	ARG2 NOS2	3.53e-05	4	85	2	25451938
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	CUL3 SULT1C2 OSBPL3 CHAF1A SVIL ZNF516 SNX33 HSF5 KIAA0753	4.81e-05	689	85	9	36543142
Pubmed	Efficient regulation of branching morphogenesis via fibroblast growth factor receptor 2c in early-stage embryonic mouse salivary glands.	FGFR1 FGFR3	5.87e-05	5	85	2	27206683
Pubmed	Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane.	STAT2 KPNA2	5.87e-05	5	85	2	17596301
Pubmed	Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference.	FGFR1 FGFR3	5.87e-05	5	85	2	15987787
Pubmed	The expression profiles of fibroblast growth factor 9 and its receptors in developing mice testes.	FGFR1 FGFR3	5.87e-05	5	85	2	27078042
Pubmed	Different intracellular trafficking of FGF1 endocytosed by the four homologous FGF receptors.	FGFR1 FGFR3	5.87e-05	5	85	2	16091423
Pubmed	FGF-dependent regulation of VEGF receptor 2 expression in mice.	FGFR1 FGFR3	5.87e-05	5	85	2	21633168
Pubmed	FGF21 signalling pathway and metabolic traits - genetic association analysis.	FGFR1 FGFR3	5.87e-05	5	85	2	20717167
Pubmed	RNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophy.	DUX4L2 DUX4	5.87e-05	5	85	2	19359275
Pubmed	Expression of fibroblast growth factor receptors in peri-implantation mouse embryos.	FGFR1 FGFR3	5.87e-05	5	85	2	9771645
Pubmed	Nectin-1 binds and signals through the fibroblast growth factor receptor.	FGFR1 FGFR3	5.87e-05	5	85	2	22955284
Pubmed	Persistent fibroblast growth factor 23 signalling in the parathyroid glands for secondary hyperparathyroidism in mice with chronic kidney disease.	FGFR1 FGFR3	5.87e-05	5	85	2	28094278
Pubmed	Expression and biological activity of mouse fibroblast growth factor-9.	FGFR1 FGFR3	5.87e-05	5	85	2	8576175
Pubmed	Craniosynostosis: genes and mechanisms.	FGFR1 FGFR3	5.87e-05	5	85	2	9300656
Pubmed	Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1.	FGFR1 FGFR3	5.87e-05	5	85	2	19696444
Pubmed	Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children.	ARG2 NOS2	5.87e-05	5	85	2	21039601
Pubmed	Overlapping expression and redundant activation of mesenchymal fibroblast growth factor (FGF) receptors by alternatively spliced FGF-8 ligands.	FGFR1 FGFR3	5.87e-05	5	85	2	9013630
Pubmed	The mouse Fgfrl1 gene coding for a novel FGF receptor-like protein.	FGFR1 FGFR3	5.87e-05	5	85	2	11566361
Pubmed	Functional analysis of secreted and transmembrane proteins critical to mouse development.	ATRN MBTPS1 PTK7	6.03e-05	31	85	3	11431694
Pubmed	Fgfr1 and Fgfr2 have distinct differentiation- and proliferation-related roles in the developing mouse skull vault.	FGFR1 FGFR3	8.80e-05	6	85	2	10572038
Pubmed	FGF2 concentration regulates the generation of neurons and glia from multipotent cortical stem cells.	FGFR1 FGFR3	8.80e-05	6	85	2	9010207
Pubmed	Trans-activation of EphA4 and FGF receptors mediated by direct interactions between their cytoplasmic domains.	FGFR1 FGFR3	8.80e-05	6	85	2	16365308
Pubmed	Fibroblast growth factor 8 signaling through fibroblast growth factor receptor 1 is required for the emergence of gonadotropin-releasing hormone neurons.	FGFR1 FGFR3	8.80e-05	6	85	2	18566132
Pubmed	Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity.	FGFR1 FGFR3	8.80e-05	6	85	2	10574949
Pubmed	FGFR3 and FGFR4 do not mediate renal effects of FGF23.	FGFR1 FGFR3	8.80e-05	6	85	2	18753255
Pubmed	Regulation of fibroblast growth factor-23 signaling by klotho.	FGFR1 FGFR3	8.80e-05	6	85	2	16436388
Pubmed	A protective role for FGF-23 in local defence against disrupted arterial wall integrity?	FGFR1 FGFR3	8.80e-05	6	85	2	23523568
Pubmed	Neuron-derived FGF9 is essential for scaffold formation of Bergmann radial fibers and migration of granule neurons in the cerebellum.	FGFR1 FGFR3	8.80e-05	6	85	2	19232523
Pubmed	Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation.	FGFR1 FGFR3	8.80e-05	6	85	2	19966287
Pubmed	Central role of the proximal tubular αKlotho/FGF receptor complex in FGF23-regulated phosphate and vitamin D metabolism.	FGFR1 FGFR3	8.80e-05	6	85	2	29720668
Pubmed	Gyrification of the cerebral cortex requires FGF signaling in the mammalian brain.	FGFR1 FGFR3	8.80e-05	6	85	2	29132503
Pubmed	Suppression of BMP signaling restores mitral cell development impaired by FGF signaling deficits in mouse olfactory bulb.	FGFR1 FGFR3	8.80e-05	6	85	2	38056728
Cytoband	4q35.2	DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L7	1.51e-09	27	85	5	4q35.2
Cytoband	Ensembl 112 genes in cytogenetic band chr4q35	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L7	8.93e-08	117	85	6	chr4q35
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	FGFR1 FGFR3 TEK PTK7	6.46e-06	40	55	4	321
GeneFamily	PRD class homeoboxes and pseudogenes	DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L7	8.70e-06	92	55	5	521
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	FGFR1 FGFR3 NECTIN3 ROBO3 PTK7	1.28e-04	161	55	5	593
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	SELP FGFR1 FGFR3 NECTIN3 LY75 TEK	1.21e-03	394	55	6	471
GeneFamily	Immunoglobulin like domain containing	NECTIN3 ROBO3 TEK PTK7	2.81e-03	193	55	4	594
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SELP ATRN	6.91e-03	41	55	2	1298
GeneFamily	PDZ domain containing	TIAM1 LMO7 SIPA1L3	1.11e-02	152	55	3	1220
GeneFamily	Fibronectin type III domain containing	PTPRG ROBO3 TEK	1.27e-02	160	55	3	555
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SELP CSMD1	1.30e-02	57	55	2	1179
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	SPATS2L PTPRG ZSWIM5 SIPA1L3 PHACTR4 EXTL3 PTK7	4.54e-08	186	80	7	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	SPATS2L PTPRG ZSWIM5 SIPA1L3 PHACTR4 EXTL3 PTK7	4.54e-08	186	80	7	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM53 SULT1C2 ZSWIM5 TAS1R3 SIPA1L3 CSMD1	5.33e-07	165	80	6	6d315e0734079ad05336cc2c3f24d870c9105bc8
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM53 SULT1C2 ZSWIM5 TAS1R3 SIPA1L3 CSMD1	5.33e-07	165	80	6	84f5597b1bb75f42de9a224196bb8ac198bbe3bf
ToppCell	facs-Lung-nan-3m-Endothelial-Capillary_Aerocyte_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OLFML2A SLC16A9 PTPRG LMO7 FGFR3 NECTIN3	1.18e-06	189	80	6	09dd2b3d89416192e84abe302a6237b8f3fdcb6e
ToppCell	IPF-Epithelial-Basal\|Epithelial / Disease state, Lineage and Cell class	ARG2 PTPRG TIAM1 SVIL SEMA5A FGFR3	1.21e-06	190	80	6	4f15842b424eefadbfe451875e517cf70e29607f
ToppCell	10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	OLFML2A ITGA11 PTPRG SEMA5A FGFR1 PRSS23	1.50e-06	197	80	6	c165c6fd12dc649b39e920d8528e2eb65c61956b
ToppCell	Int-URO-Other\|Int-URO / Disease, Lineage and Cell Type	SULT1C2 LMO7 SEMA5A NECTIN3 FAAH	7.82e-06	151	80	5	ea5f25842e621be41a6491c9959d419d9cc7ebd6
ToppCell	Int-URO-Other-RBC\|Int-URO / Disease, Lineage and Cell Type	SULT1C2 LMO7 SEMA5A NECTIN3 FAAH	7.82e-06	151	80	5	0344d482f1c55c9eaa15beb8d6bac1c6cdca21b3
ToppCell	368C-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	CHST15 CHAF1A ANKIB1 DSEL PTK7	1.43e-05	171	80	5	f3bf5805823d5733b58742172e7668725ce82931
ToppCell	368C-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CHAF1A ANKIB1 DSEL FAAH PTK7	1.43e-05	171	80	5	714a0b0d0c9886fef64170cf53eb64f0d8a47280
ToppCell	Endothelial-A-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	SELP LARP6 BMPER PRSS23 TEK	1.47e-05	172	80	5	a3201773a25832e92dd113fad165f1ecd37f5e91
ToppCell	droplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OLFML2A SKIDA1 TEK SBK3 TDRD12	1.60e-05	175	80	5	7be76d39e1a4f4ac709672cd2d409a2523a083ce
ToppCell	tumor_Lung-Endothelial_cells-EPCs\|tumor_Lung / Location, Cell class and cell subclass	OLFML2A ZSWIM5 PRSS23 TEK SIRT4	1.69e-05	177	80	5	f8b152c09d56a97e8c0482fb1a3964c05f9dc8c5
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHST15 SEMA5A BMPER PTK7 SORCS1	1.78e-05	179	80	5	7954c0026754ab869b88ab7feb13c2f27d6e272d
ToppCell	10x3'2.3-week_12-13-Mesenchymal_osteo-stroma-chondrocyte\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	PLAC1 FGFR1 FGFR3 PRSS23 ITPRID1	1.93e-05	182	80	5	ed487f3a774812caa2903a646b60c86edcc1e65e
ToppCell	metastatic_Brain-Endothelial_cells-Stalk-like_ECs\|metastatic_Brain / Location, Cell class and cell subclass	PTPRG FAM124A FGFR1 ROBO3 TEK	2.09e-05	185	80	5	ad52970e88e8947ef256095bd4b40229b912d58a
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SELP PTPRG PRSS23 CSMD1 TEK	2.09e-05	185	80	5	a7ae76058b2082020cadec49d63b9f4e24d21734
ToppCell	Adult-Endothelial-endothelial_cell_of_artery\|Adult / Lineage, Cell type, age group and donor	SELP BMPER PRSS23 CSMD1 TEK	2.14e-05	186	80	5	2d1c4ea2e401db89971582ee54618a8b0c81b8ac
ToppCell	Endothelial-A-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	SELP BMPER PRSS23 TEK NOS2	2.20e-05	187	80	5	febe0b99a6a815ce687160a0e7af55228b1d5beb
ToppCell	Control-Endothelial_cells-Arterial_endothelial_cells\|Control / group, cell type (main and fine annotations)	SELP PTPRG PRSS23 CSMD1 TEK	2.20e-05	187	80	5	81affaab3fe3e1daea45ada6445e906ddd33950e
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SELP PTPRG PRSS23 CSMD1 TEK	2.37e-05	190	80	5	f6c38d197fd9d69a4f97cb2e72cd4747984c1a86
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SELP PTPRG PRSS23 CSMD1 TEK	2.43e-05	191	80	5	50601ef0a5a8f2c2120922989e08e85bf2d9b4ab
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Capillary_Aerocyte_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OLFML2A SLC16A9 LMO7 FGFR3 NECTIN3	2.43e-05	191	80	5	df8cdbc26443e55a203cbafa21b0952a2a55b9bf
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SULT1C2 OSBPL3 SLC43A1 CPEB4 FGFR3	2.49e-05	192	80	5	ee27d27e3d269764dbe8711d0b37ff9331a298a9
ToppCell	10x5'v1-week_17-19-Mesenchymal_osteo-stroma-early_osteoblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ITGA11 PTPRG SEMA5A FGFR1 BMPER	2.55e-05	193	80	5	5e46a9f65e85aca78f825fdef88a95b97eec8743
ToppCell	droplet-Lung-30m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC16A9 LMO7 SEMA5A FGFR3 NECTIN3	2.62e-05	194	80	5	cf7f232827945fbafd2c298c08a799ab916c2472
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LARP6 FGFR1 NECTIN3 PRSS23 TEK	2.62e-05	194	80	5	7b6ec45adb7ece3c8a7b78c5782413b5825effe2
ToppCell	BL-critical-LOC-Epithelial-Basal\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SLC16A9 PTPRG SEMA5A FGFR3 PRSS23	2.62e-05	194	80	5	2932f704656ca368565ec12f3452af3b18e8df12
ToppCell	10x5'v1-week_17-19-Endothelial-stroma-sinusoidal_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	PTPRG FAM124A FGFR1 TEK NOS2	2.68e-05	195	80	5	22a481927147ec4ae9d59e6af7c87df0e9cb51e4
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ATRN SULT1C2 OSBPL3 CPEB4 PRSS23	2.68e-05	195	80	5	a38d9dc6192aea673d96fda6b25e81223fda3abf
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_pericyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	OLFML2A SPATS2L SVIL SEMA5A PRSS23	2.75e-05	196	80	5	cb61757646653f89faba503cb5d99e5dd5197b4c
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SELP OLFML2A PTPRG TEK NOS2	2.75e-05	196	80	5	023312af38f816a44b407e0daa32590d953caf99
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ITGA11 LARP6 FGFR1 PRSS23 TEK	2.75e-05	196	80	5	ed6047b48b6a96baa6a90c7af784e7c34b32824d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SULT1C2 LMO7 OSBPL3 SIPA1L3 CPEB4	2.75e-05	196	80	5	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_pericyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	OLFML2A SPATS2L SVIL SEMA5A PRSS23	2.75e-05	196	80	5	44e2df1b61e3819eae7e482bef0a733afe852d67
ToppCell	Sepsis-Int-URO-Others-RBC\|Int-URO / Disease, condition lineage and cell class	SULT1C2 LMO7 SEMA5A DSEL FAAH	2.89e-05	198	80	5	29203aaa5c1844f72289e03f585cd5e7fc498a9a
ToppCell	Sepsis-Int-URO-Others\|Int-URO / Disease, condition lineage and cell class	SULT1C2 LMO7 SEMA5A DSEL FAAH	2.89e-05	198	80	5	67f721ea8e60042317ba12efd584f56b07cfb29d
ToppCell	Parenchyma_COVID-19-Endothelial-TX-Artery\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	SELP PTPRG FAM124A PRSS23 TEK	3.03e-05	200	80	5	34b279804475ea58fbb052b96f44128c082627a9
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Vein\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SELP OLFML2A PTPRG PRSS23 TEK	3.03e-05	200	80	5	7eb366b2c5394af7c77650bde6261e7dac67154e
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_venous\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SELP PTPRG FAM124A PRSS23 TEK	3.03e-05	200	80	5	84e145619a500530f42ed0fe72468ae95f4cbf1e
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-Myofibroblasts\|Fibroblasts / Location, Cell class and cell subclass	ITGA11 SPATS2L SVIL FGFR1 PRSS23	3.03e-05	200	80	5	eabb7d4aa92ace7d970bcd3fae2c7cb5400a43b4
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Artery\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	SELP PTPRG FAM124A PRSS23 TEK	3.03e-05	200	80	5	8552cc7a439449b30b59760c3e8667217b9852b5
ToppCell	proximal-3-Epithelial-Proximal_Basal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ARG2 LARP6 SEMA5A FGFR3 PRSS23	3.03e-05	200	80	5	3a0c84f9a551fc2581ec3693481eada297d83f7b
ToppCell	proximal-Epithelial-Proximal_Basal-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ARG2 LARP6 SEMA5A FGFR3 PRSS23	3.03e-05	200	80	5	de9aec87c86ad0a1bd5e0737c2aae0ec6f269bca
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Artery-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SELP PTPRG FAM124A PRSS23 TEK	3.03e-05	200	80	5	45c08f1befe78553bbadcc2fcffb6138306638f3
ToppCell	proximal-Epithelial-Proximal_Basal\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ARG2 LARP6 SEMA5A FGFR3 PRSS23	3.03e-05	200	80	5	ff2afa5c0352c214525129f9ff85afc139fe44d2
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Lcn2)--\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SELP LY75 TEK NOS2	4.80e-05	111	80	4	9ba3590be8862c23b6e2917caed8bdbd9f9c2753
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Lcn2)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SELP LY75 TEK NOS2	4.80e-05	111	80	4	3e38efb22c47506ef2e2c1e19c79450e11d0ce56
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Lcn2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SELP LY75 TEK NOS2	4.80e-05	111	80	4	cd84f2a9102a6eb63226ecde11d4ece54ff99b48
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Hpgd\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CHST15 FGFR1 ROBO3 SORCS1	7.87e-05	126	80	4	9b04ca8a46cc30119baf6ef27711a0b2a6b4a0c9
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SELP LY75 TEK NOS2	9.15e-05	131	80	4	d5bc40cd585582856881081b7130dec3515b4ae0
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Gpc3_Slc18a3\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SELP TIAM1 SVIL SEMA5A	1.09e-04	137	80	4	d346086f42d8f04d3fa67fe696834284acdc7080
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SELP LY75 TEK NOS2	1.15e-04	139	80	4	34398a6f21a1e670497655a7bb7f3cde9e117560
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SELP LY75 TEK NOS2	1.15e-04	139	80	4	450c4152c9fe4ec503271bb3cf93739918c59509
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TIAM1 SVIL SEMA5A FGFR3	1.32e-04	144	80	4	0322fef818a963be00535d5f141f028d43de5c6a
ToppCell	Multiple_Sclerosis-Lymphocyte-T_NK-dnT\|Multiple_Sclerosis / Disease, Lineage and Cell Type	FAM124A FGFR1 PTTG2 PTK7	1.35e-04	145	80	4	d24894be1d6664df9a6af8ea33f2ffce0c718635
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-7\|TCGA-Endometrium / Sample_Type by Project: Shred V9	SELP LEFTY2 OLFML2A TEK	1.35e-04	145	80	4	ffbdadea0185e5d3b85f2868d5ec82b50cf2e2a1
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_3\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TAS1R3 GPR156 ROBO3 CSMD1	1.39e-04	146	80	4	2ac9b487a7991fdc15444aeb93533030e09825bb
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPATS2L FBXL18 FGFR1 HSF5	1.84e-04	157	80	4	beab0ac47202266b04543c02cfcdda012375e879
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular-6\|TCGA-Stomach / Sample_Type by Project: Shred V9	EDEM3 OSBPL3 SIPA1L3 ASIC3	1.93e-04	159	80	4	655c0749c238bd68cb797adb83e25a23b8a3cc9d
ToppCell	VE-CD8-CD4_Treg\|VE / Condition, Cell_class and T cell subcluster	SELP EXTL3 SIRT4 HSF5	2.02e-04	161	80	4	a114f4f75859d9ef900e5146686438d051241429
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ITGA11 LARP6 FGFR1 TEK	2.07e-04	162	80	4	56f1789e69a6cb29956e46aba92b290847327c1f
ToppCell	facs-Marrow-T_cells-18m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPATS2L SLC41A3 OSBPL3 FAAH	2.27e-04	166	80	4	c22b0f3bf990d94b615a3aacee5de548da2db628
ToppCell	facs-Marrow-T_cells-18m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPATS2L SLC41A3 OSBPL3 FAAH	2.27e-04	166	80	4	0975fc165bcc7e85f053d9d0244fffe407c23571
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-ILC3\|GI_small-bowel / Manually curated celltypes from each tissue	TIAM1 SVIL DSEL SORCS1	2.27e-04	166	80	4	773673a5d0430640439845b264740bfbbdad0cb2
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC16A9 CSMD1 SORCS1 TDRD12	2.32e-04	167	80	4	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	368C-Myeloid-Dendritic-pDC\|368C / Donor, Lineage, Cell class and subclass (all cells)	CHST15 CHAF1A ANKIB1 FAAH	2.32e-04	167	80	4	1e2fc1637769405a61f4c7e44945712a1888a299
ToppCell	Adult-Endothelial-endothelial_cell_of_artery-D231\|Adult / Lineage, Cell type, age group and donor	SELP FAM124A PRSS23 TEK	2.38e-04	168	80	4	aca34c51758c65925ad24110294a72b2dea6db72
ToppCell	10x5'-GI_small-bowel-Lymphocytic_Invariant-Inducer-like\|GI_small-bowel / Manually curated celltypes from each tissue	LARP6 TIAM1 SVIL SORCS1	2.38e-04	168	80	4	d02eba7ece17edcdd47fd6b784c93910ce61090f
ToppCell	facs-Lung-nan-3m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELP PTPRG PRSS23 TEK	2.49e-04	170	80	4	8e1f757ed62218c0fb6525f49d142dd2cd29acf9
ToppCell	droplet-Fat-Bat-18m\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRN CSMD1 TCTN2 KIAA0753	2.49e-04	170	80	4	c720d81bc29a8fd1f1249c6af408471d561f1d5d
ToppCell	facs-Lung-nan-3m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELP PTPRG PRSS23 TEK	2.49e-04	170	80	4	67d7e1da3ebd2d14cb2e67799e94d655027ed5c4
ToppCell	10x5'-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-ILC3\|GI_small-bowel / Manually curated celltypes from each tissue	LARP6 TIAM1 SVIL SORCS1	2.49e-04	170	80	4	97df5ffb328196c46568975d2d97722bcc753bf5
ToppCell	droplet-Fat-Bat\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRN CSMD1 TCTN2 KIAA0753	2.49e-04	170	80	4	c4ecdfc2b4710da0a5fbb20e9df02536023badb1
ToppCell	droplet-Lung-30m-Hematologic-myeloid-classical_monocyte_proliferating-\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CHAF1A POLH FGFR1 KPNA2	2.54e-04	171	80	4	1efce222989460bb59bd9fa955e7d9a60c73994c
ToppCell	Control-Epithelial_cells-Airway_basal\|Control / group, cell type (main and fine annotations)	FBXL18 SEMA5A FGFR3 PRSS23	2.54e-04	171	80	4	3965ced4be6db14265a90673502fceee425837ca
ToppCell	facs-Heart-RV-18m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARG2 LY75 FAAH HSF5	2.60e-04	172	80	4	a26a73c41e5a05c9dd47a99f3320295f684c5e54
ToppCell	droplet-Liver-nan-3m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TREML4 SLC16A9 SEMA5A TCTN2	2.60e-04	172	80	4	f814b6134ad608015765399d54cc1e5e1873ed34
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SULT1C2 OSBPL3 CPEB4 PRSS23	2.66e-04	173	80	4	0c74bdb40e635d906fd180412c23bf7fed61621e
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Airway_fibro\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	GPR156 FGFR1 PRSS23 HSF5	2.66e-04	173	80	4	b23b408acc29a667cce104429afef1a6cf2720a5
ToppCell	facs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SELP RAET1E ASIC3 TEK	2.72e-04	174	80	4	40bb87d219aafab0357ab0d797efd38085fc0312
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D231\|Adult / Lineage, Cell type, age group and donor	SELP BMPER PRSS23 TEK	2.72e-04	174	80	4	2dd647c4fdf99fd1f7b838efef01baf2cbc3446d
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	OLFML2A FAM124A PRSS23 TEK	2.78e-04	175	80	4	2e54961846c65b185d9bd6e305dd81205579d890
ToppCell	Adult-Endothelial-endothelial_cell_of_artery-D175\|Adult / Lineage, Cell type, age group and donor	SELP BMPER CSMD1 TEK	2.78e-04	175	80	4	0a65ddfa8c2e8efb5b5338cf07661cb78157a23c
ToppCell	RSV-Healthy-2\|Healthy / Virus stimulation, Condition and Cluster	HROB OSBPL3 CHAF1A SLC43A1	2.78e-04	175	80	4	c47440c0b0513e67fe13b85f10dd8a8d42d0e9a3
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Proximal_progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SULT1C2 LMO7 OSBPL3 FGFR3	2.78e-04	175	80	4	6759d200a133034756de9cdf2d5daceca927aac9
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	OLFML2A FAM124A PRSS23 TEK	2.78e-04	175	80	4	efa6a05f7417d46141b6e635f258c126b7a03aa1
ToppCell	RSV-Healthy-2\|RSV / Virus stimulation, Condition and Cluster	HROB OSBPL3 CHAF1A SLC43A1	2.78e-04	175	80	4	0e97189585b7afaf3bd622c3ef10c86412393829
ToppCell	droplet-Pancreas-Exocrine-18m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELP CHST15 PRSS23 TEK	2.84e-04	176	80	4	eb63eb2c301e785196ccadac74a2940b2c524c62
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EDEM3 SPATS2L SLC41A3 FAAH	2.84e-04	176	80	4	8e4600efeea095a92178cfd26d7c58db7dfc0c80
ToppCell	ASK452-Epithelial-Secretory\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	EDEM3 LMO7 KIAA0753 SORCS1	2.84e-04	176	80	4	dd334c8a8a31dc26b2d558df0ef6bed6dc1a6610
ToppCell	Adult-Endothelial-endothelial_cell_of_vein\|Adult / Lineage, Cell type, age group and donor	SELP BMPER PRSS23 TEK	2.84e-04	176	80	4	043683c61c5d1a7f8a4666a612310246bd3d83a2
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEMA5A FGFR1 DSEL PTK7	2.90e-04	177	80	4	57033ee0d49a4a50fc25328a4a44d4de2b35f505
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LMO7 SEMA5A BMPER PTK7	2.90e-04	177	80	4	4c069f0d044a96118090b85ca592a21d6b5d9399
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EDEM3 SLC41A3 OSBPL3 FAAH	2.90e-04	177	80	4	9b4c1ca5c6fca9a7a936dad49a04155903ef9c32
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHST15 SEMA5A BMPER PTK7	2.90e-04	177	80	4	bde307e67ad8e48a5ff4c0827015f4688f6b3e46
ToppCell	Endothelial-A-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	SELP BMPER PRSS23 TEK	2.96e-04	178	80	4	2f2602b9305d55f25afa9861dd6c6347ae179337
ToppCell	COPD-Endothelial-VE_Venous\|World / Disease state, Lineage and Cell class	SELP PTPRG PRSS23 TEK	3.03e-04	179	80	4	9968da1adcb561d9bf167a42ab5d9de85c071c4a
ToppCell	COPD-Endothelial-VE_Venous\|Endothelial / Disease state, Lineage and Cell class	SELP PTPRG PRSS23 TEK	3.03e-04	179	80	4	e816dd846a6918ec143b57a380c3a47ed073b66e
Computational	RTK signaling.	FGFR1 FGFR3 TEK PTK7	3.85e-05	46	45	4	MODULE_259
Computational	Genes in the cancer module 85.	FGFR1 FGFR3 TEK PTK7	5.80e-05	51	45	4	MODULE_85
Computational	Genes in the cancer module 199.	FGFR1 FGFR3 TEK PTK7	9.01e-05	57	45	4	MODULE_199
Computational	Genes in the cancer module 200.	PTPRG FGFR1 TEK	1.87e-04	27	45	3	MODULE_200
Drug	Chlorprothixene hydrochloride [6469-93-8]; Down 200; 11.4uM; MCF7; HT_HG-U133A	ARG2 RABL6 FBXL18 POLH SIPA1L3 AKAP10 TCTN2	6.80e-06	193	83	7	5291_DN
Drug	Etodolac [41340-25-4]; Down 200; 14uM; PC3; HT_HG-U133A	RABL6 OLFML2A EDEM3 SLC41A3 FGFR1 EXTL3 ROBO3	7.03e-06	194	83	7	2091_DN
Drug	H-89, Dihydrochloride; Up 200; 0.5uM; PC3; HT_HG-U133A	ARG2 EDEM3 OSBPL3 CHAF1A SLC43A1 EXTL3 ROBO3	7.03e-06	194	83	7	6921_UP
Drug	Ampyrone [83-07-8]; Down 200; 19.6uM; MCF7; HT_HG-U133A	ATRN POLH SIPA1L3 ZNF516 FGFR1 EXTL3 ASIC3	7.27e-06	195	83	7	6845_DN
Drug	Azlocillin sodium salt [37091-65-9]; Down 200; 8.2uM; PC3; HT_HG-U133A	OLFML2A EDEM3 HROB TIAM1 LMO7 SEMA5A TCTN2	8.30e-06	199	83	7	5788_DN
Drug	N-stearoylethanolamine	ARG2 NOS2 FAAH	1.65e-05	14	83	3	CID000027902
Disease	TWIST1-related craniosynostosis	FGFR1 FGFR3	4.23e-05	4	79	2	cv:C4551902
Disease	bone disease (implicated_via_orthology)	FGFR1 FGFR3	7.04e-05	5	79	2	DOID:0080001 (implicated_via_orthology)
Disease	scoliosis (implicated_via_orthology)	FGFR3 PTK7	7.04e-05	5	79	2	DOID:0060249 (implicated_via_orthology)
Disease	Craniosynostosis syndrome	FGFR1 FGFR3	1.47e-04	7	79	2	cv:C0010278
Disease	hydroxyproline measurement	CSMD1 SORCS1	3.14e-04	10	79	2	EFO_0010498
Disease	creativity measurement	SPATS2L SLC16A9	3.14e-04	10	79	2	EFO_0010650
Disease	NG-monomethyl-arginine measurement	CSMD1 TDRD12	3.83e-04	11	79	2	EFO_0010510
Disease	FEV/FEC ratio	SPATS2L SVIL ZNF516 CPEB4 SKIDA1 FGFR1 FGFR3 SNX33 PRSS23 CSMD1 KPNA2	4.18e-04	1228	79	11	EFO_0004713
Disease	glycodeoxycholate measurement	SVIL CSMD1	6.31e-04	14	79	2	EFO_0010493
Disease	gliosarcoma	FGFR1 FGFR3	8.29e-04	16	79	2	C0206726
Disease	idiopathic scoliosis (implicated_via_orthology)	MBTPS1 PTK7	8.29e-04	16	79	2	DOID:0060250 (implicated_via_orthology)
Disease	Brachycephaly	FGFR1 FGFR3	9.38e-04	17	79	2	C0221356
Disease	acute lymphoblastic leukemia, response to antineoplastic agent	SPATS2L LMBRD2	1.18e-03	19	79	2	EFO_0000220, GO_0097327
Disease	abdominal fat cell number	SELP SPATS2L SNX33 ITPRID1	2.00e-03	198	79	4	EFO_0021534
Disease	obesity (is_marker_for)	SELP FGFR1 NOS2	2.55e-03	101	79	3	DOID:9970 (is_marker_for)
Disease	non-alcoholic fatty liver disease severity measurement	PTPRG SEMA5A	2.56e-03	28	79	2	EFO_0008421
Disease	malaria	TREML4 CHST15 CSMD1	2.62e-03	102	79	3	EFO_0001068

Protein segments in the cluster

Peptide	Gene	Start	Entry
CPKWPNPDAPISSTF	PTPRG	1316	P23470
RPSSCLCWPFQAQPL	nan	196	Q6ZRM9
PQLPGFSWIKPCISS	ARG2	176	P78540
KPSWDQVLPSCNAPC	CSMD1	1611	Q96PZ7
PLPNCFTTPLRQAWT	AKAP10	471	O43572
AFVENNPAIKWCPTP	ANKIB1	411	Q9P2G1
QKSASSLPASPPCLW	LINC00518	91	Q8N0U6
SQALQEPAPWSALPC	DUX4L6	356	P0CJ89
PCQWSYVTSVPSAPK	CHAF1A	836	Q13111
NFTIKSLSRPGQPWC	RAET1E	36	Q8TD07
PAPQQCSEPETKWSS	RABL6	486	Q3YEC7
TWLNSLKPQDPVPCF	NOS2	946	P35228
TCPSPQSWISPFLQS	YWHAH-AS1	71	Q9Y442
WDTCNKQLPKPAPTT	SLC16A9	486	Q7RTY1
LFTIAKTWNQPNCPT	nan	1201	O00370
SQALQEPAPWSALPC	DUX4	356	Q9UBX2
SWAKPQPLNETAPSN	MBTPS1	931	Q14703
QWPCSSMPAKQAPPS	ITPRID1	336	Q6ZRS4
PGCSVPVPANQSFWT	ATRN	316	O75882
WTCPNTQILFPNDPL	EDEM3	526	Q9BZQ6
LNCTLNWPIEAFPAP	SLC43A1	211	O75387
SQALQEPAPWSALPC	DUX4L3	356	P0CJ86
PNPPWSFQRSKSLFC	FAM124A	351	Q86V42
PNPGNAFDQFLPKCW	LMO7	411	Q8WWI1
SPVLNTPWIPFQNCC	LY75	1241	O60449
SPCTSPWSSPLAQRK	LARP6	376	Q9BRS8
YPNPWGLPCSQSKVS	KLKP1	56	Q107X0
FPCQPFQSPSSWLSG	HROB	296	Q8N3J3
SCQQQQLSFLPPPWG	ASIC3	266	Q9UHC3
TNPKDNSFLACSPLW	ITGA11	111	Q9UKX5
PSEPELNLNSWPCKS	PHACTR4	556	Q8IZ21
WTLSNLCRNKNPAPP	KPNA2	231	P52292
KPACPASTSPLNWLA	KDM3A	811	Q9Y4C1
NSSFKWQSPAEPCVL	BMPER	116	Q8N8U9
CQAKPQGWNTPQPFL	DBF4B	591	Q8NFT6
FKCPSSGTPNPTLRW	FGFR1	176	P11362
KNQPKPSLPTEWALC	EXTL3	401	O43909
GYWPTQSATPKCNIP	CUL3	511	Q13618
SQALQEPAPWSALPC	DUX4L7	356	P0CJ90
TCQQPPEALAFNWPF	LEFTY2	296	O00292
ASGIWTNKPPQCLAA	SELP	246	P16109
PCLSKASPDLPEQWQ	GPR156	711	Q8NFN8
NNLNKPPSPWSSYQS	CPEB4	276	Q17RY0
CSNPLFGQTVNPWKS	FAAH	196	O00519
CPAAGNPTPSISWLK	FGFR3	176	P22607
SQALQEPAPWSALPC	DUX4L5	356	P0CJ88
ATACFPWDVALAPNP	SBK3	236	P0C264
LVFAPSPSSQCNKPW	DSEL	501	Q8IZU8
LPAPCPSSSNISLWN	OSBPL3	516	Q9H4L5
KSCPWLSLPGNSAIS	PRR14L	276	Q5THK1
EALQCPSQPPKWTFS	PRR14L	1751	Q5THK1
TAPPSSLNPCENEWK	OLFML2A	91	Q68BL7
IPVSCAAPQKSPWLT	PLAC1	111	Q9HBJ0
STPINPNNFPAKLWR	HSF5	6	Q4G112
NQQFFSNPPKAPWSL	STAT2	481	P52630
GLQWSAEQPCNPSKP	SPATS2L	176	Q9NUQ6
CSWVASATQNVPKPP	SVIL	391	O95425
ANPVPSQHPCFKPWS	LMBRD2	86	Q68DH5
APSFNKLNPALTLWP	TDRD12	231	Q587J7
QACPQPSSVFWSLLK	FBXL18	466	Q96ME1
CAVGQVSPYSAPWKP	PRSS23	16	O95084
NLQSWAPKASPVYCP	SKIDA1	521	Q1XH10
PQWKANPHPFACSVE	SNX33	221	Q8WV41
SPPEASRPWVCQKSF	SIPA1L3	326	O60292
SAKGRWIANPSQPCS	SIRT4	11	Q9Y6E7
PLQMKKFWPNPCSTF	SLC41A3	351	Q96GZ6
SPPWECNLLQSPSSI	PTTG2	171	Q9NZH5
PWSNCKALPNSLPTE	POLH	556	Q9Y253
NPTSPPASPKCAAWL	KIAA0753	561	Q2KHM9
CNTNPCPELKKTTPW	SEMA5A	696	Q13591
VIPNKFLPNSKSPCW	CHST15	186	Q7LFX5
AVLLNSFSPPAWPQF	PAK6-AS1	111	Q8N910
SCNSVAPPWIQPNGY	ZNF516	786	Q92618
SWPCPERSKNLPQVS	LINC02912	116	Q8N9X5
NASGCPAQDPVKPWQ	TAS1R3	411	Q7RTX0
LSPSPVSPAKRQCSW	ZSWIM5	11	Q9P217
VSPAKRQCSWPSPQA	ZSWIM5	16	Q9P217
RGPYQPKSWCQQTSP	TREML4	46	Q6UXN2
PSWFCLPNNQPALTV	TIAM1	766	Q13009
STQLLPPSFWENNCK	SULT1C2	111	O00338
FQCETKGNPPPAIFW	ROBO3	366	Q96MS0
EIPDQPCWSQKNSPS	TMEM53	11	Q6P2H8
FNPICKASGWPLPTN	TEK	366	Q02763
QCLPAFWFNPSSLSK	SORCS1	741	Q8WY21
CQFSAQPPPSLQWLF	PTK7	246	Q13308
WFPFLCVQSPLANTP	TCTN2	231	Q96GX1
PCNCTAWSASTLQPP	SOX14	201	O95416
SQALQEPAPWSALPC	DUX4L2	356	P0CJ85
CNADANPPPFKSVWS	NECTIN3	291	Q9NQS3