Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-like ligase-substrate adaptor activity	PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF11	3.84e-05	82	92	5	GO:1990756
GeneOntologyMolecularFunction	enzyme-substrate adaptor activity	PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF11	7.77e-05	95	92	5	GO:0140767
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF11	1.20e-04	55	92	4	GO:0042974
GeneOntologyBiologicalProcess	blastocyst formation	WDR74 POMZP3 PRAMEF15 BYSL PRAMEF4 PRAMEF11	1.41e-06	78	93	6	GO:0001825
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF11	2.18e-06	47	94	5	GO:0031462
HumanPheno	Finger flexor weakness	FLNC DYSF	2.71e-05	2	27	2	HP:0031177
MousePheno	abnormal spermatogonia proliferation	KNSTRN PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF11	4.08e-06	47	72	5	MP:0002685
Domain	EGF_LAM_2	CELSR3 MEGF8 NTN5 LAMA3 AGRN	2.69e-07	30	88	5	PS50027
Domain	EGF_LAM_1	CELSR3 MEGF8 NTN5 LAMA3 AGRN	2.69e-07	30	88	5	PS01248
Domain	Laminin_EGF	CELSR3 MEGF8 NTN5 LAMA3 AGRN	6.01e-07	35	88	5	PF00053
Domain	EGF_Lam	CELSR3 MEGF8 NTN5 LAMA3 AGRN	6.01e-07	35	88	5	SM00180
Domain	Laminin_EGF	CELSR3 MEGF8 NTN5 LAMA3 AGRN	9.19e-07	38	88	5	IPR002049
Domain	PLAC	ADAMTSL1 ADAMTS3 PAPLN ADAMTSL4	1.69e-06	19	88	4	PS50900
Domain	PLAC	ADAMTSL1 ADAMTS3 PAPLN ADAMTSL4	1.69e-06	19	88	4	IPR010909
Domain	PLAC	ADAMTSL1 PAPLN ADAMTSL4	3.54e-05	14	88	3	PF08686
Domain	PRAME_family	PRAMEF25 PRAMEF15 PRAMEF4	9.27e-05	19	88	3	IPR026271
Domain	HJURP_C	HJURP MEF2C	1.31e-04	4	88	2	IPR022102
Domain	HJURP_C	HJURP MEF2C	1.31e-04	4	88	2	PF12347
Domain	ADAM_spacer1	ADAMTS3 PAPLN ADAMTSL4	1.67e-04	23	88	3	IPR010294
Domain	ADAM_spacer1	ADAMTS3 PAPLN ADAMTSL4	1.67e-04	23	88	3	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTSL1 ADAMTS3 PAPLN	1.90e-04	24	88	3	IPR013273
Domain	TSP_1	ADAMTSL1 ADAMTS3 PAPLN ADAMTSL4	2.22e-04	63	88	4	PF00090
Domain	TSP1	ADAMTSL1 ADAMTS3 PAPLN ADAMTSL4	2.50e-04	65	88	4	SM00209
Domain	TSP1_rpt	ADAMTSL1 ADAMTS3 PAPLN ADAMTSL4	2.50e-04	65	88	4	IPR000884
Domain	TSP1	ADAMTSL1 ADAMTS3 PAPLN ADAMTSL4	2.50e-04	65	88	4	PS50092
Domain	LAM_G_DOMAIN	CELSR3 LAMA3 AGRN	7.57e-04	38	88	3	PS50025
Domain	LamG	CELSR3 LAMA3 AGRN	1.16e-03	44	88	3	SM00282
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TANC2 FLNC CRYBG2 EHBP1L1 B4GALNT4 PWWP2B CELSR3 MEGF8 BTBD7 PAPLN DYSF POM121C AGRN PLEKHH3 MVB12B KLHL17	5.08e-08	1105	95	16	35748872
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF11	3.68e-07	22	95	4	31729367
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF11	6.32e-07	25	95	4	37451217
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF11	1.02e-06	28	95	4	25089626
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF11	2.56e-06	35	95	4	19389355
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF15 PRAMEF4 PRAMEF11	1.31e-05	17	95	3	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF15 PRAMEF4 PRAMEF11	1.31e-05	17	95	3	37781892
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF15 PRAMEF4 PRAMEF11	1.56e-05	18	95	3	29731491
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF15 PRAMEF4 PRAMEF11	1.56e-05	18	95	3	23894331
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF15 PRAMEF4 PRAMEF11	1.56e-05	18	95	3	14675769
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF15 PRAMEF4 PRAMEF11	1.56e-05	18	95	3	12890732
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF15 PRAMEF4 PRAMEF11	1.56e-05	18	95	3	39181896
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF15 PRAMEF4 PRAMEF11	1.85e-05	19	95	3	28604677
Pubmed	ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.	PRAMEF15 PABPC1L PRAMEF4 PRAMEF11	1.98e-05	58	95	4	31598710
Pubmed	An abundance of X-linked genes expressed in spermatogonia.	PRAMEF15 PRAMEF4 TEX14 PRAMEF11	2.12e-05	59	95	4	11279525
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF15 PRAMEF4 PRAMEF11	2.18e-05	20	95	3	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF15 PRAMEF4 PRAMEF11	2.18e-05	20	95	3	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF15 PRAMEF4 PRAMEF11	2.18e-05	20	95	3	21425410
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF15 PRAMEF4 PRAMEF11	3.36e-05	23	95	3	19480014
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF15 PRAMEF4 PRAMEF11	4.35e-05	25	95	3	12620990
Pubmed	The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPδ and RhoGAP2.	ARHGAP22 PTPRD	4.41e-05	4	95	2	21926414
Pubmed	Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene.	ADAMTSL1 TRIM11	4.41e-05	4	95	2	25271088
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF15 PRAMEF4 PRAMEF11	4.90e-05	26	95	3	18500982
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTSL1 ADAMTS3 PAPLN ADAMTSL4	5.47e-05	75	95	4	20637190
Pubmed	A human MAP kinase interactome.	CSDE1 FLNC TCF20 LAMA3 MACF1 POM121C MEF2C FBXO30	5.76e-05	486	95	8	20936779
Pubmed	Transcriptome-based systematic identification of extracellular matrix proteins.	LAMA3 PAPLN AGRN ADAMTSL4	6.71e-05	79	95	4	18757743
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF15 PRAMEF4 PRAMEF11	7.60e-05	30	95	3	38786026
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CSDE1 WDR74 FLNC TCF20 ARHGAP23 PLEKHG3 DHX38 BYSL PYCR1 MACF1 AGRN PHIP KIF2C	7.95e-05	1353	95	13	29467282
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF15 PRAMEF4 PRAMEF11	9.25e-05	32	95	3	37889087
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	CSDE1 FKBP10 CELSR3 GOPC PPT1 MEGF8 CHST14 DNAJC1 ITGA1 AGRN DIPK2A KIF2C	1.06e-04	1201	95	12	35696571
Pubmed	Laminins promote the locomotion of skeletal myoblasts via the alpha 7 integrin receptor.	LAMA3 ITGA1	1.54e-04	7	95	2	9004048
Pubmed	Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.	CELSR3 MEGF8	2.62e-04	9	95	2	9693030
Pubmed	Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.	PRAMEF15 PRAMEF4 PRAMEF11	2.75e-04	46	95	3	17287250
Pubmed	Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene.	PTPRD PPT1	3.28e-04	10	95	2	11978849
Pubmed	EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis.	MACF1 KIF2C	3.28e-04	10	95	2	23001180
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	PRAMEF15 PRAMEF4 PRAMEF11	3.53e-04	50	95	3	31806660
Pubmed	Candidate-gene testing for orphan limb-girdle muscular dystrophies.	FLNC TRIM11	4.00e-04	11	95	2	19472918
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TANC2 ARHGAP23 PLEKHG3 DHX38 MACF1 MINAR1 POM121C	4.16e-04	493	95	7	15368895
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	TANC2 MACF1 AGRN MEF2C	4.30e-04	128	95	4	30995482
Pubmed	Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney function.	LAMA3 AGRN	4.79e-04	12	95	2	16750824
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	FKBP10 EHBP1L1 TRIM11 PTPRD TCF20 MEGF8 PPP1R3E RTL10 PUS1 CARNS1	4.83e-04	1021	95	10	26760575
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	CSDE1 CRYBG2 PRAMEF25 PRAMEF9 HHAT MACF1 PRAMEF4 ADAMTSL4 PRAMEF11 KLHL17	5.20e-04	1031	95	10	16710414
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	VWA3A ARHGAP22 EHBP1L1 TRIM11 PTPRD ADAMTS3 PRAMEF15 BRD7 PABPC1L PRAMEF4 PRAMEF11	5.80e-04	1242	95	11	30973865
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TANC2 TCF20 NKD2 MEGF8 PLEKHG3 PPP1R3E HJURP MACF1 KIF2C	5.90e-04	861	95	9	36931259
Pubmed	Reduced Abd-B Hox function during kidney development results in lineage infidelity.	SLC12A1 LTA	6.58e-04	14	95	2	29596840
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	DHX38 PRAMEF15 HJURP MACF1 ANKRD12 PRAMEF4 QSER1 AGRN PRAMEF11 KIF2C	7.65e-04	1084	95	10	11544199
Pubmed	ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice.	ADAMTS3 LAMA3	8.64e-04	16	95	2	30579834
Pubmed	Psychiatric risk gene Transcription Factor 4 (TCF4) regulates the density and connectivity of distinct inhibitory interneuron subtypes.	CORT MEF2C	8.64e-04	16	95	2	37770578
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	WDR74 ARHGAP22 NKD2 MEGF8 PYCR1 AGRN ADAMTSL4	8.81e-04	560	95	7	21653829
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CSDE1 TCF20 MEGF8 BTBD7 MACF1 ANKRD12	8.96e-04	407	95	6	12693553
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	TANC2 CSDE1 WDR74 ARHGAP22 GOPC ARHGAP23 PLEKHG3 BYSL PYCR1	9.13e-04	916	95	9	32203420
Pubmed	MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders.	GRM4 MEF2C	9.78e-04	17	95	2	27779093
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	ADAMTSL1 LAMA3 PAPLN AGRN	1.16e-03	167	95	4	22159717
Pubmed	The functional interactome landscape of the human histone deacetylase family.	WDR74 HJURP ANKRD12 PHIP MEF2C	1.21e-03	289	95	5	23752268
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TANC2 PTPRD TCF20 BRD7 MACF1 QSER1 GRM4 AGRN KIF2C	1.29e-03	963	95	9	28671696
Pubmed	Deletion of Fibroblast growth factor 9 globally and in skeletal muscle results in enlarged tuberosities at sites of deltoid tendon attachments.	AGRN MEF2C	1.36e-03	20	95	2	34091985
Pubmed	TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.	TRIM11 TRIM35	1.50e-03	21	95	2	18248090
Pubmed	Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.	CRYBG2 ADAMTSL1 SLC2A13	1.60e-03	84	95	3	15203218
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	TANC2 EHBP1L1 TCF20 PPT1 MEGF8 PYCR1 POM121C	1.86e-03	638	95	7	31182584
Pubmed	Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4.	CSDE1 GOPC DNAJC1 POM121C	1.90e-03	191	95	4	31177093
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CSDE1 FLNC TCF20 DHX38 BYSL MACF1 PHIP	2.12e-03	653	95	7	22586326
Pubmed	AP-2δ is a crucial transcriptional regulator of the posterior midbrain.	HJURP MEF2C	2.13e-03	25	95	2	21858141
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	TCF20 PPT1 DHX38 PUS1 POM121C	2.48e-03	341	95	5	32971831
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CSDE1 PLEKHG3 DHX38 BRD7 PTRH1 BYSL MACF1 DECR2 DNAJC1 AGRN KIF2C	2.58e-03	1497	95	11	31527615
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	SLC12A1 PTPRD PPT1 MEGF8 KRT32 LAMA3 PABPC1L DYSF AGRN	2.64e-03	1070	95	9	23533145
Pubmed	Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle.	MEGF8 BYSL	2.66e-03	28	95	2	28655764
Pubmed	The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation.	STXBP5L AGRN	2.66e-03	28	95	2	24448406
Cytoband	1p36.21	PRAMEF25 PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF11	4.13e-09	63	95	6	1p36.21
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	CRYBG2 PRAMEF25 PRAMEF9 CORT PRAMEF15 PRAMEF4 PRAMEF26 AGRN PRAMEF11 KLHL17	1.57e-06	681	95	10	chr1p36
Cytoband	11q13.2	ACY3 TCIRG1 CARNS1	1.30e-04	47	95	3	11q13.2
Cytoband	17q21.2	FKBP10 KRT32 PLEKHH3	4.25e-04	70	95	3	17q21.2
Cytoband	6p21.3	PHF1 LTA GRM4 TULP1	1.85e-03	250	95	4	6p21.3
GeneFamily	PRAME family	PRAMEF25 PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF11	2.40e-10	24	66	6	686
GeneFamily	ADAMTS like	ADAMTSL1 PAPLN ADAMTSL4	1.61e-06	7	66	3	947
Coexpression	GSE27786_LIN_NEG_VS_NEUTROPHIL_DN	PHF1 SLC12A1 TCIRG1 PABPC1L DNAJC1 ADAMTSL4 MVB12B	6.87e-06	200	92	7	M4795
Coexpression	NABA_BASEMENT_MEMBRANES	NTN5 LAMA3 PAPLN AGRN	1.18e-05	40	92	4	M5887
Coexpression	NABA_MATRISOME	VWA3A POMZP3 ADAMTSL1 MEGF8 ADAMTS3 IL17B NTN5 LAMA3 PAPLN LTA MMP19 AGRN ADAMTSL4	4.99e-05	1008	92	13	MM17056
Coexpression	NABA_MATRISOME_PRIMARY_METASTATIC_COLORECTAL_TUMOR	ADAMTSL1 MEGF8 PAPLN AGRN	5.58e-05	59	92	4	M47989
Coexpression	NABA_ECM_GLYCOPROTEINS	VWA3A POMZP3 NTN5 LAMA3 PAPLN AGRN	5.87e-05	191	92	6	MM17059
Coexpression	NABA_MATRISOME	VWA3A POMZP3 ADAMTSL1 MEGF8 ADAMTS3 IL17B NTN5 LAMA3 PAPLN LTA MMP19 AGRN ADAMTSL4	5.97e-05	1026	92	13	M5889
Coexpression	NABA_ECM_GLYCOPROTEINS	VWA3A POMZP3 NTN5 LAMA3 PAPLN AGRN	6.77e-05	196	92	6	M3008
ToppCell	AT1-AT2_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	FLNC CRYBG2 MYO3B ASCL5 LAMA3 AGRN PLEKHH3	8.79e-08	172	95	7	0be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCell	PCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ZDHHC12 ADAMTSL1 KNSTRN MYO3B HJURP LAMA3 KIF2C	1.99e-07	194	95	7	c197e4acbff42a9f0410b6801c2bfcf6160aefc1
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-Mesoderm\|6m / Sample Type, Dataset, Time_group, and Cell type.	FLNC EHBP1L1 IL17B TEX14 DYSF CARNS1 MEF2C	2.45e-07	200	95	7	0f6851baf0cf2a8b0c95a7a585c4407c330c5f6c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	VWA3A ARHGAP23 ADAMTS3 PLEKHG3 LAMA3 AGRN	3.14e-06	188	95	6	b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	VWA3A ARHGAP23 ADAMTS3 PLEKHG3 LAMA3 AGRN	3.14e-06	188	95	6	874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADAMTSL1 KNSTRN MYO3B HJURP LAMA3 KIF2C	3.44e-06	191	95	6	39220f4a345e328f7fa4fd462a0abeea821b3e02
ToppCell	TCGA-Colorectal-Primary_Tumor\|TCGA-Colorectal / Sample_Type by Project: Shred V9	WDR74 HJURP BYSL PUS1 PYCR1 KIF2C	4.35e-06	199	95	6	c7d6a8398f2419b726a0461585d1ee0561654e3b
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	WDR74 HJURP BYSL PUS1 PYCR1 KIF2C	4.35e-06	199	95	6	85b3b1ad01368dae4adbc9da7efc148e49992f69
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_PP_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR74 MYO3B PTRH1 PABPC1L CARNS1	2.54e-05	162	95	5	ca1014e32996f777bff021830ce9a7cf4acf58d5
ToppCell	wk_15-18-Epithelial-Airway_epithelial_progenitor-epi-stalk_intermediate\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CRYBG2 ZDHHC12 ADAMTSL1 HJURP KIF2C	2.77e-05	165	95	5	4297588f809e8a8275ab1a6ed99daac7ad93bd61
ToppCell	Basal_cells-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	CRYBG2 B4GALNT4 ARHGAP23 PLEKHG3 TULP1	2.85e-05	166	95	5	aea2ae12e4746149ebc6da063ef694381c098f80
ToppCell	droplet-Lung-nan-3m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRYBG2 B4GALNT4 HJURP NTN5 KIF2C	3.11e-05	169	95	5	df2c9c706bfc9db2bc5726602a49f5f5a94e9481
ToppCell	droplet-Lung-nan-3m-Lymphocytic-Proliferating_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRYBG2 B4GALNT4 HJURP NTN5 KIF2C	3.11e-05	169	95	5	f6a6d2f614d60395ad9b867ff1cf59eba72b04ce
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTPRD KNSTRN HJURP DIPK2A KIF2C	3.38e-05	172	95	5	29c8510f26527d487d0fc3543102d067cdb281a6
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	WDR74 CRYBG2 KNSTRN ACY3 KIF2C	3.67e-05	175	95	5	8958c5c30437d20a4abd70d7527990f7e2a68b93
ToppCell	Nasal_Brush-Epithelial-Basal_2\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	FKBP10 PTPRD ADAMTS3 KRT32 LAMA3	3.77e-05	176	95	5	fc5787946f5a10056d326d070620575ae4081836
ToppCell	Nasal_Brush-Epithelial-Basal_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	FKBP10 PTPRD ADAMTS3 KRT32 LAMA3	3.77e-05	176	95	5	5daaba0853afe7d20d4635169ccd4f96e735b938
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS3 KNSTRN HJURP ITGA1 KIF2C	3.87e-05	177	95	5	2b63f0529ef73e0eede9b7ef1f08b0a0426a9c82
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STXBP5L HJURP PABPC1L MEF2C DIPK2A	4.09e-05	179	95	5	7c8a2fa1326c73dc9e774df645b572864fd97133
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Hematopoietic\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	FKBP10 ACY3 HJURP PYCR1 FBXO30	4.31e-05	181	95	5	9dc0563453e24c9d1d975e2e0e1e272487e19908
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FKBP10 NKD2 IL17B ITGA1 MMP19	4.31e-05	181	95	5	c6d2a13df3b74fade3b0c71e285b4c14c8e52413
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Hematopoietic-Megakaryocytic\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	FKBP10 ACY3 HJURP PYCR1 FBXO30	4.31e-05	181	95	5	14c2dd946e89ba578711c2d25935b6b3d319b701
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Hematopoietic-Megakaryocytic-Megakaryocyte\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	FKBP10 ACY3 HJURP PYCR1 FBXO30	4.31e-05	181	95	5	c5843b89f3d362e236ff76c3279518a2fdfc1f75
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	FKBP10 ACY3 HJURP PYCR1 FBXO30	4.31e-05	181	95	5	fcefb5902416c004631f4f8dd5c8f99fe3bd90bc
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FKBP10 NKD2 IL17B ITGA1 MMP19	4.31e-05	181	95	5	c62b0a2422377ffadaab63edd538e87a06fa5017
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Monophasic_Synovial_Sarcoma-5\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF11	4.72e-05	93	95	4	3e05ea0f8f4a7cdb78a596f47d563dc3c94d4d8e
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IL17B ASCL5 ITGA1 MEF2C PLEKHH3	5.03e-05	187	95	5	d52f7bc0afcdc366b20d199ab33c4ec60ed22a68
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_Erythro-Mega-Erythrocytic_early\|lymph-node_spleen / Manually curated celltypes from each tissue	HJURP BYSL PYCR1 PLEKHH3 KIF2C	5.03e-05	187	95	5	61d346c9873c2edb3ce224a0c063c54d9a68309e
ToppCell	367C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	KNSTRN ACY3 HJURP MEF2C KIF2C	5.16e-05	188	95	5	f5102e8d95506c25c675094b86162a6a50087b64
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IL17B ASCL5 ITGA1 MEF2C PLEKHH3	5.43e-05	190	95	5	a7f6c38bbf451f166febb21e6719d4afced4035e
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PTPRD LAMA3 SLC2A13 GRM4 MEF2C	5.43e-05	190	95	5	1bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IL17B ASCL5 ITGA1 MEF2C PLEKHH3	5.56e-05	191	95	5	239c1e68eb1cbe3e137a99fbd6eeb8d64c919ffd
ToppCell	mLN-T_cell-gd_T\|T_cell / Region, Cell class and subclass	KNSTRN PUS1 NMUR1 ITGA1 DYSF	6.29e-05	196	95	5	8f476408cd5a4ea9d25c763c66565343d7989b38
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IL17B ASCL5 ITGA1 MEF2C PLEKHH3	6.44e-05	197	95	5	b7e399b8e1a1ffc2b359f14929f199b93d9bbcce
ToppCell	IPF-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	TANC2 PTPRD NKD2 MACF1 MMP19	6.44e-05	197	95	5	f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PLEKHG3 IL17B ITGA1 MEF2C PLEKHH3	6.92e-05	200	95	5	b5b5a32925f225610fe25a021a742d6397162863
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Pericyte-Pericyte_3\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PLEKHG3 IL17B ITGA1 MEF2C PLEKHH3	6.92e-05	200	95	5	9169a9ec8e9ab95d90a64c5a19ac666a5cf82313
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Pericyte-Pericyte_3\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PLEKHG3 IL17B ITGA1 MEF2C PLEKHH3	6.92e-05	200	95	5	a3a1e35934d676c39f917652e50c502cb2f613c1
ToppCell	Control_saline-Mesenchymal_myocytic-Pericyte\|Control_saline / Treatment groups by lineage, cell group, cell type	PLEKHG3 IL17B ITGA1 MEF2C PLEKHH3	6.92e-05	200	95	5	cb7ef774b6d300f8019c5b16a04e3ebd165e4f1c
Disease	Intellectual Disability	TANC2 CSDE1 TCF20 PUS1 PYCR1 MACF1 PHIP MEF2C	5.35e-05	447	87	8	C3714756
Disease	hip circumference, psychosocial stress measurement	ADAMTSL1 TRIM11	1.79e-04	7	87	2	EFO_0005093, EFO_0006783
Disease	heart failure	FLNC ADAMTSL1 DYSF POM121C PHIP	2.24e-04	185	87	5	EFO_0003144
Disease	twisted gastrulation protein homolog 1 measurement	ANKRD12 MEF2C	2.38e-04	8	87	2	EFO_0803205
Disease	Opioid use measurement	PTPRD MVB12B	8.80e-04	15	87	2	EFO_0009937
Disease	sexual dimorphism measurement	EHBP1L1 ADAMTS3 ACY3 MACF1 DNAJC1 GRM4 DYSF CARNS1 PHIP TULP1	1.54e-03	1106	87	10	EFO_0021796
Disease	Obsessive-compulsive trait	PTPRD HHAT	1.74e-03	21	87	2	HP_0008770
Disease	azoospermia (implicated_via_orthology)	PTPRD GOPC	2.88e-03	27	87	2	DOID:14227 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
AMSRCVLEPRPPGKR	PTRH1	16	Q86Y79
PPQQSARRDRMPCRN	CORT	81	O00230
MCSLPVPREPLRRVA	ACY3	1	Q96HD9
PPRRPLTVADIRSGM	CFAP77	31	Q6ZQR2
LVDRRPLGPPSCMQL	ASCL5	81	Q7RTU5
RPPDMRACSLGPCER	ADAMTSL4	896	Q6UY14
NERLSTRPPPNMICL	BRD7	561	Q9NPI1
SRSSCSQRRPPPPGM	C2orf27A	176	P0DPF5
PYDMRPTENRTGCRP	GRM4	561	Q14833
RTRRPEMLLRPESCP	AGRN	336	O00468
MPRGRCRQQGPRIPI	RTL10	1	Q7L3V2
VMVACGLRPALPTRP	CARNS1	716	A5YM72
SAPRLMVLRQPRGPD	CSDE1	766	O75534
GRPTIEVRRCSMPSV	ANKRD12	1301	Q6UB98
MTAPCSQPAQLPGRR	DNAJC1	1	Q96KC8
VLCLRMAPPEPAGSR	C5orf38	121	Q86SI9
CLSPRNQPRRMCLPD	HJURP	446	Q8NCD3
TRRPGTQMVRTFCPP	QSER1	1176	Q2KHR3
CFSRRPMPTREPPKT	OCEL1	51	Q9H607
CRGRNDLKRPMQAPP	GOPC	256	Q9HD26
FRPAPRVIRCMTNTP	PYCR1	111	P32322
CRSRIPSPLQPEMQG	LIN37	176	Q96GY3
EMTGQCRCPPRTVRP	LAMA3	1321	Q16787
GPVPDSAVCMLVRPR	NMUR1	211	Q9HB89
PPPRTGPCRQRAVME	IL17B	156	Q9UHF5
PRPQMCSPKLTAQRI	GRXCR2	71	A6NFK2
VPRTVCVPRTVGMPC	KRT32	426	Q14532
IRPCMLATCARPGRP	ADAMTSL1	841	Q8N6G6
TRARMRQPRCGLEDP	MMP19	76	Q99542
VRMTSPSRRPIPCKL	FLNC	1001	Q14315
TGRRCLPLSMDVRAP	DECR2	76	Q9NUI1
MPEARCRGTPEAPPR	EHBP1L1	446	Q8N3D4
SPMPRSPEECRRLRT	MEGF8	1916	Q7Z7M0
PVQDCPRMRGRQPLT	PRAMEF15	136	P0DUQ1
MGKPLSRPDCLRRNP	MACF1	1	O94854
LMISRQRLCAVPPPN	MEF2C	126	Q06413
RPSCASMVRPPVVPR	PABPC1L	441	Q4VXU2
MAPRPRARPGVAVAC	ITGA1	1	P56199
GPPAGQDREPTRCRM	NKD2	186	Q969F2
MRSCFCVRRSRDPPP	MVB12B	1	Q9H7P6
SRMVCSPVTVRIAPP	POM121C	241	A8CG34
MRLDGLTPPALPRCV	HHAT	311	Q5VTY9
LRAVAQRCPSPPMIN	PPT1	121	P50897
RPRTCPQMSGELPRV	PANO1	86	I0J062
PQMSGELPRVRPTRV	PANO1	91	I0J062
MGDRPESRRPCNRVP	ADAMTS3	951	O15072
QGACMGERRRITIPP	FKBP10	331	Q96AY3
RTRPRQARPAAPMEG	KLHL17	41	Q6TDP4
DLRRPMRTVPGPLFT	DMRTB1	176	Q96MA1
GRPRCDLLQAMPRTE	DIPK2A	131	Q8NDZ4
ALPRGRQVSRMVPPV	CRYBG2	206	Q8N1P7
GFPRRTRLMVRSAPP	C19orf73	61	Q9NVV2
ESPLLTMRQPGRCRV	BTBD7	721	Q9P203
TMRQPGRCRVNSTPP	BTBD7	726	Q9P203
ARGPMPVHTTCKRPR	FAM90A20P	146	A6NIJ5
PVLRPLSRPGSQECM	CELSR3	3091	Q9NYQ7
RRCMTRPEPGISCDL	FBXO30	16	Q8TB52
MEPRAGCRLPVRVEQ	PWWP2B	1	Q6NUJ5
GRCICQPSLERMPRL	DYSF	1241	O75923
RPSCPAVAEIPLRMV	KIF2C	151	Q99661
VQDCPRMRGRQPLTV	PRAMEF26	41	H0Y7S4
APRERTTRLGPRMPQ	BYSL	81	Q13895
RRVKTCNPPDAGPMV	PTPRD	1536	P23468
GPTPVMGTQEARRCL	MINAR1	341	Q9UPX6
RPTDARCLPSSPIRM	PHF1	436	O43189
PVICRMLSYPPTRRA	SLC2A13	311	Q96QE2
RRLFCTMEPEPVQPG	TRIM35	261	Q9UPQ4
RRPGPLMQGVLQTCR	PLEKHH3	281	Q7Z736
MSRAVRLPVPCPVQL	TEX14	1	Q8IWB6
RSPRMPCQRIPEATT	NTN5	316	Q8WTR8
MVEPPLSGRVGRCRS	PLEKHG3	1086	A1L390
TLRLGPRPSCSPRMA	PUS1	16	Q9Y606
MSRERPPGTDIPRNL	PPP1R3E	1	Q9H7J1
RRAPGVQPCRLVTMT	KNSTRN	66	Q9Y448
PVQDCPRMRGRQPLT	PRAMEF25	136	A6NGN4
RPQCIVLTGGPMTRP	SLC12A1	681	Q13621
ITSGSCPGTPEMRRR	TANC2	426	Q9HCD6
SIPCLNVKTRPVRMP	STXBP5L	606	Q9Y2K9
EQSRSPGRMPCPHRL	ARHGAP22	21	Q7Z5H3
PVVMRLSCGSSPRDP	B4GALNT4	941	Q76KP1
RTLRAVCGQPGMPRD	CHST14	111	Q8NCH0
PGMSAENERVPIRPR	TULP1	426	O00294
PVEDCPRMKGRQPLT	PRAMEF4	136	O60810
MTPPERLFLPRVCGT	LTA	1	P01374
ELRVGPGVCRMRQDP	WDR74	126	Q6RFH5
PPEVVPMELRTVCRV	TRIM11	261	Q96F44
ITDTIPRRCPFVPQM	PHIP	946	Q8WWQ0
IRMTCRAEGFPPPAI	PAPLN	1061	O95428
VPRRAGERRCPAMAP	ARHGAP23	296	Q9P227
PVQDCPRMRGRQPLT	PRAMEF9	136	P0DUQ2
PPPERCRRRRLGSVM	USP35	601	Q9P2H5
MRLCLIPRNTGTPQR	nan	1	A8MX80
PVQDCPRMRGRQPLT	PRAMEF11	136	O60813
EQGEPMTPRRTPARF	DHX38	1211	Q92620
QDSRPTPMRRVPGRV	TCF20	981	Q9UGU0
MRLCLIPRNTGTPQR	nan	1	Q8N9G6
MSPEVTCPRRGHLPR	SLC46A2	1	Q9BY10
QTAMVPPAIPLRRCR	ZDHHC12	86	Q96GR4
MVCSPVTLRIAPPDR	POMZP3	1	Q6PJE2
LCPPRPTVPLGARMS	VWA3A	751	A6NCI4
RIPCRDMPPTLIRTN	TCIRG1	351	Q13488
TPRRRCQQPKMLSSP	MYO3B	1256	Q8WXR4