Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transporter activity	GJA9 SLC35D1 SPNS1 ABCC4 SLC9C1 SLC46A3 ATP7A ABCA6 SLC10A5 CYB561D2 SLC6A19 TMEM38A ATP11C CACNG5 MFSD8 SLC2A2 UNC80 SLC52A3	2.47e-07	1289	69	18	GO:0005215
GeneOntologyMolecularFunction	transmembrane transporter activity	GJA9 SLC35D1 SPNS1 ABCC4 SLC9C1 SLC46A3 ATP7A ABCA6 SLC10A5 CYB561D2 SLC6A19 TMEM38A CACNG5 MFSD8 SLC2A2 UNC80 SLC52A3	3.72e-07	1180	69	17	GO:0022857
GeneOntologyMolecularFunction	1-phosphatidylinositol-3-kinase regulator activity	PIK3R1 SOCS5 SOCS4	2.14e-05	16	69	3	GO:0046935
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC35D1 ABCC4 SLC9C1 SLC46A3 ATP7A ABCA6 SLC10A5 CYB561D2 SLC6A19	3.73e-05	477	69	9	GO:0022804
GeneOntologyMolecularFunction	G protein-coupled receptor activity	TAS2R16 TAS2R14 GPR18 OR6C4 LPAR6 MC2R OR6K3 OR6C65 GRM1 OR52B6 TAAR6 FFAR4	4.52e-05	884	69	12	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	SEMA4D TAS2R16 TAS2R14 GPR18 LMBR1L OR6C4 LPAR6 TLR3 MC2R OR6K3 OR6C65 GRM1 OR52B6 TAAR6 FFAR4	4.72e-05	1353	69	15	GO:0004888
GeneOntologyMolecularFunction	taste receptor activity	TAS2R16 TAS2R14 FFAR4	2.00e-04	33	69	3	GO:0008527
GeneOntologyMolecularFunction	copper ion transmembrane transporter activity	SLC46A3 ATP7A	3.25e-04	8	69	2	GO:0005375
GeneOntologyBiologicalProcess	serotonin metabolic process	ATP7A CYP2D6 PDE1B	2.82e-05	18	69	3	GO:0042428
GeneOntologyBiologicalProcess	chondroitin sulfate biosynthetic process	SLC35D1 CHSY1 CHST12	3.92e-05	20	69	3	GO:0030206
GeneOntologyBiologicalProcess	chemical homeostasis	LETM2 MLXIPL SPNS1 SLC9C1 ATP7A PIK3R1 CYP11B1 SEC24A CYB561D2 TMEM38A GRM1 SLC2A2 UNC80 SOAT1	5.55e-05	1249	69	14	GO:0048878
GeneOntologyBiologicalProcess	primary amino compound metabolic process	ATP7A CYP2D6 PDE1B	6.05e-05	23	69	3	GO:1901160
GeneOntologyBiologicalProcess	chondroitin sulfate proteoglycan biosynthetic process	SLC35D1 CHSY1 CHST12	8.82e-05	26	69	3	GO:0050650
GeneOntologyBiologicalProcess	lipid localization	DENND5B MEST SPNS1 ABCC4 ABCA6 SLC10A5 SEC24A ATP11C SOAT1	1.07e-04	565	69	9	GO:0010876
GeneOntologyBiologicalProcess	chondroitin sulfate metabolic process	SLC35D1 CHSY1 CHST12	1.23e-04	29	69	3	GO:0030204
GeneOntologyBiologicalProcess	indole-containing compound metabolic process	ATP7A CYP2D6 PDE1B	1.51e-04	31	69	3	GO:0042430
GeneOntologyBiologicalProcess	ammonium ion metabolic process	ATP7A CYP2D6 PDE1B	1.66e-04	32	69	3	GO:0097164
GeneOntologyBiologicalProcess	positive regulation of lamellipodium assembly	ATP7A NCKAP1 PIK3R1	1.66e-04	32	69	3	GO:0010592
GeneOntologyBiologicalProcess	chondroitin sulfate proteoglycan metabolic process	SLC35D1 CHSY1 CHST12	2.17e-04	35	69	3	GO:0050654
GeneOntologyBiologicalProcess	lipid transport	DENND5B SPNS1 ABCC4 ABCA6 SLC10A5 SEC24A ATP11C SOAT1	2.79e-04	506	69	8	GO:0006869
GeneOntologyBiologicalProcess	positive regulation of lamellipodium organization	ATP7A NCKAP1 PIK3R1	3.24e-04	40	69	3	GO:1902745
GeneOntologyBiologicalProcess	positive regulation of Rho protein signal transduction	SEMA4D GPR18 LPAR6	3.49e-04	41	69	3	GO:0035025
GeneOntologyBiologicalProcess	copper ion transmembrane transport	SLC46A3 ATP7A	3.91e-04	9	69	2	GO:0035434
GeneOntologyCellularComponent	phosphatidylinositol 3-kinase complex	PIK3R1 SOCS5 SOCS4	1.23e-04	29	70	3	GO:0005942
GeneOntologyCellularComponent	endoplasmic reticulum membrane	SLC35D1 MEST CYP2D6 LMBR1L PIK3R1 SEC24A TLR3 CYB561D2 ZDHHC22 TMEM38A ATP11C GGCX SOAT1	3.18e-04	1293	70	13	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	SLC35D1 MEST CYP2D6 LMBR1L PIK3R1 SEC24A TLR3 CYB561D2 ZDHHC22 TMEM38A ATP11C GGCX SOAT1	3.33e-04	1299	70	13	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	SLC35D1 MEST CYP2D6 LMBR1L PIK3R1 SEC24A TLR3 CYB561D2 ZDHHC22 TMEM38A ATP11C GGCX SOAT1	4.08e-04	1327	70	13	GO:0042175
GeneOntologyCellularComponent	inner dynein arm	DNHD1 DNAH12	4.89e-04	10	70	2	GO:0036156
GeneOntologyCellularComponent	lysosomal membrane	SPNS1 SLC46A3 TLR3 ATP11C MFSD8 PGAP6 FFAR4	8.89e-04	462	70	7	GO:0005765
GeneOntologyCellularComponent	lytic vacuole membrane	SPNS1 SLC46A3 TLR3 ATP11C MFSD8 PGAP6 FFAR4	8.89e-04	462	70	7	GO:0098852
GeneOntologyCellularComponent	vacuolar membrane	SPNS1 SLC46A3 TLR3 ATP11C MFSD8 PGAP6 FFAR4	1.52e-03	507	70	7	GO:0005774
Domain	SOCS	SOCS5 SOCS4	1.31e-05	2	68	2	PF12610
Domain	SOCS4/SOCS5_dom	SOCS5 SOCS4	1.31e-05	2	68	2	IPR022252
Domain	MFS	SPNS1 SLC46A3 MFSD8 SLC2A2	6.48e-04	108	68	4	PS50850
Domain	GPCR_Rhodpsn_7TM	GPR18 OR6C4 LPAR6 MC2R OR6K3 OR6C65 OR52B6 TAAR6 FFAR4	6.93e-04	670	68	9	IPR017452
Domain	7tm_1	GPR18 OR6C4 LPAR6 MC2R OR6K3 OR6C65 OR52B6 TAAR6 FFAR4	7.47e-04	677	68	9	PF00001
Domain	G_PROTEIN_RECEP_F1_1	GPR18 OR6C4 LPAR6 MC2R OR6K3 OR6C65 OR52B6 TAAR6 FFAR4	8.11e-04	685	68	9	PS00237
Domain	G_PROTEIN_RECEP_F1_2	GPR18 OR6C4 LPAR6 MC2R OR6K3 OR6C65 OR52B6 TAAR6 FFAR4	8.63e-04	691	68	9	PS50262
Domain	GPCR_Rhodpsn	GPR18 OR6C4 LPAR6 MC2R OR6K3 OR6C65 OR52B6 TAAR6 FFAR4	8.72e-04	692	68	9	IPR000276
Domain	Dynein_heavy_dom-2	DNHD1 DNAH12	1.16e-03	14	68	2	IPR013602
Domain	DHC_N2	DNHD1 DNAH12	1.16e-03	14	68	2	PF08393
Domain	DHC_fam	DNHD1 DNAH12	1.33e-03	15	68	2	IPR026983
Domain	Dynein_heavy_dom	DNHD1 DNAH12	1.33e-03	15	68	2	IPR004273
Domain	Dynein_heavy	DNHD1 DNAH12	1.33e-03	15	68	2	PF03028
Domain	MFS_dom	SPNS1 SLC46A3 MFSD8 SLC2A2	1.45e-03	134	68	4	IPR020846
Domain	SOCS	SOCS5 SOCS4	2.38e-03	20	68	2	SM00253
Domain	MFS_1	SPNS1 SLC46A3 MFSD8	2.79e-03	77	68	3	PF07690
Domain	MFS	SPNS1 SLC46A3 MFSD8	2.79e-03	77	68	3	IPR011701
Domain	TAS2R	TAS2R16 TAS2R14	4.01e-03	26	68	2	PF05296
Domain	T2R	TAS2R16 TAS2R14	4.01e-03	26	68	2	IPR007960
Domain	SH2	PIK3R1 SOCS5 SOCS4	5.96e-03	101	68	3	PF00017
Domain	-	ATP7A ATP11C	6.04e-03	32	68	2	3.40.1110.10
Domain	-	ATP7A ATP11C	6.04e-03	32	68	2	2.70.150.10
Domain	ATPase_P-typ_cyto_domN	ATP7A ATP11C	7.19e-03	35	68	2	IPR023299
Domain	SH2	PIK3R1 SOCS5 SOCS4	7.55e-03	110	68	3	SM00252
Domain	P_typ_ATPase	ATP7A ATP11C	7.60e-03	36	68	2	IPR001757
Domain	ATPase_P-typ_P_site	ATP7A ATP11C	7.60e-03	36	68	2	IPR018303
Domain	ATPASE_E1_E2	ATP7A ATP11C	7.60e-03	36	68	2	PS00154
Domain	SH2	PIK3R1 SOCS5 SOCS4	7.74e-03	111	68	3	PS50001
Domain	SH2	PIK3R1 SOCS5 SOCS4	7.93e-03	112	68	3	IPR000980
Domain	-	PIK3R1 SOCS5 SOCS4	7.93e-03	112	68	3	3.30.505.10
Domain	ATPase_P-typ_transduc_dom_A	ATP7A ATP11C	8.01e-03	37	68	2	IPR008250
Domain	E1-E2_ATPase	ATP7A ATP11C	8.01e-03	37	68	2	PF00122
Domain	SOCS_box	SOCS5 SOCS4	8.44e-03	38	68	2	PF07525
Domain	SOCS_box	SOCS5 SOCS4	8.87e-03	39	68	2	SM00969
Domain	SOCS	SOCS5 SOCS4	8.87e-03	39	68	2	PS50225
Domain	SOCS_box	SOCS5 SOCS4	8.87e-03	39	68	2	IPR001496
Domain	ABC_tran	ABCC4 ABCA6	1.32e-02	48	68	2	PF00005
Domain	-	SLC9C1 GGCX	1.32e-02	48	68	2	2.60.120.10
Domain	ABC_TRANSPORTER_2	ABCC4 ABCA6	1.32e-02	48	68	2	PS50893
Domain	ABC_TRANSPORTER_1	ABCC4 ABCA6	1.38e-02	49	68	2	PS00211
Pubmed	Sema4D deficiency enhances glucose tolerance through GLUT2 retention in hepatocytes.	SEMA4D SLC2A2	3.99e-06	2	70	2	39334386
Pubmed	The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5.	SOCS5 SOCS4	3.99e-06	2	70	2	22423360
Pubmed	Integral and associated lysosomal membrane proteins.	SPNS1 TLR3 ATP11C MFSD8 PGAP6	5.78e-06	126	70	5	17897319
Pubmed	Stearic acid suppresses mammary gland development by inhibiting PI3K/Akt signaling pathway through GPR120 in pubertal mice.	PIK3R1 FFAR4	1.20e-05	3	70	2	28712865
Pubmed	Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling.	SOCS5 SOCS4	1.20e-05	3	70	2	28195529
Pubmed	Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling.	PIK3R1 TLR3	1.20e-05	3	70	2	16858407
Pubmed	Identification and characterization of two upstream elements that regulate adrenocortical expression of steroid 11 beta-hydroxylase.	CYP11B1 TLR3	1.20e-05	3	70	2	2233742
Pubmed	Expressions of Carbohydrate Response Element Binding Protein and Glucose Transporters in Liver Cancer and Clinical Significance.	MLXIPL SLC2A2	1.20e-05	3	70	2	31407220
Pubmed	Long noncoding RNA TUSC7 inhibits cell proliferation, migration and invasion by regulating SOCS4 (SOCS5) expression through targeting miR-616 in endometrial carcinoma.	SOCS5 SOCS4	2.39e-05	4	70	2	31200002
Pubmed	Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.	SOCS5 SOCS4	3.98e-05	5	70	2	15590694
Pubmed	Targeted ablation of pituitary pre-proopiomelanocortin cells by herpes simplex virus-1 thymidine kinase differentially regulates mRNAs encoding the adrenocorticotropin receptor and aldosterone synthase in the mouse adrenal gland.	CYP11B1 MC2R	3.98e-05	5	70	2	7476975
Pubmed	CIN85/RukL is a novel binding partner of nephrin and podocin and mediates slit diaphragm turnover in podocytes.	NPHS2 PIK3R1	3.98e-05	5	70	2	20457601
Pubmed	Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling.	PIK3R1 TLR3	3.98e-05	5	70	2	15502848
Pubmed	Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) mice.	PIK3R1 SLC2A2	5.96e-05	6	70	2	12595588
Pubmed	Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action.	PIK3R1 SLC2A2	8.33e-05	7	70	2	14551916
Pubmed	Chromosomal assignment of seven genes on canine chromosomes by fluorescence in situ hybridization.	ATP7A SLC2A2	8.33e-05	7	70	2	8661696
Pubmed	Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells.	TAS2R16 TAS2R14	1.11e-04	8	70	2	11854532
Pubmed	Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring leading to altered fatty acid sensing and increased intake of high-fat food.	ATP11C SOAT1	1.11e-04	8	70	2	38833481
Pubmed	Members of RTP and REEP gene families influence functional bitter taste receptor expression.	TAS2R16 TAS2R14	1.78e-04	10	70	2	16720576
Pubmed	A family of candidate taste receptors in human and mouse.	TAS2R16 TAS2R14	2.17e-04	11	70	2	10766242
Pubmed	A plethora of taste receptors.	TAS2R16 TAS2R14	2.17e-04	11	70	2	10774719
Pubmed	The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression.	SOCS5 SOCS4	2.17e-04	11	70	2	19385048
Pubmed	T2Rs function as bitter taste receptors.	TAS2R16 TAS2R14	2.17e-04	11	70	2	10761935
Pubmed	Targeted deletion of kidney glucose-6 phosphatase leads to nephropathy.	MLXIPL NPHS2	2.60e-04	12	70	2	24717294
Pubmed	The DNA sequence, annotation and analysis of human chromosome 3.	DNAH12 CYB561D2 ERVPABLB-1	2.71e-04	62	70	3	16641997
Pubmed	Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.	SOCS5 SOCS4	3.07e-04	13	70	2	23990909
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	ABCC4 ATP7A PIK3R1 GGCX SOAT1 DOP1B	5.38e-04	504	70	6	34432599
Pubmed	Adrenal Development in Mice Requires GATA4 and GATA6 Transcription Factors.	CYP11B1 MC2R	5.98e-04	18	70	2	25933105
Pubmed	Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder.	CYP2D6 MC2R	6.68e-04	19	70	2	19095219
Pubmed	A novel family of mammalian taste receptors.	TAS2R16 TAS2R14	8.18e-04	21	70	2	10761934
Pubmed	Regulation of the endosomal SNX27-retromer by OTULIN.	ABCC4 ATP7A	8.18e-04	21	70	2	31541095
Pubmed	Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model.	ABCC4 ABCA6	8.18e-04	21	70	2	23137377
Pubmed	NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons.	NCKAP1 PIK3R1	8.99e-04	22	70	2	21946561
Pubmed	Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.	ABCC4 ABCA6	8.99e-04	22	70	2	8894702
Pubmed	Evolutionary relationships of the Tas2r receptor gene families in mouse and human.	TAS2R16 TAS2R14	8.99e-04	22	70	2	12734386
Pubmed	Embryonic osteocalcin signaling determines lifelong adrenal steroidogenesis and homeostasis in the mouse.	CYP11B1 MC2R	8.99e-04	22	70	2	34905510
Pubmed	The molecular receptive ranges of human TAS2R bitter taste receptors.	TAS2R16 TAS2R14	9.83e-04	23	70	2	20022913
Pubmed	Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.	OR6C4 OR6C65	1.07e-03	24	70	2	24152035
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	EVI5 LETM2 ABCC4 ATP7A PDE1B TMEM41A CYB561D2 MC2R DOP1B	1.12e-03	1293	70	9	15342556
Pubmed	Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex.	PDE1B CYP11B1	1.16e-03	25	70	2	30541888
Pubmed	RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion.	SOCS5 SOCS4	1.16e-03	25	70	2	29361558
Pubmed	Receptors for bitter and sweet taste.	TAS2R16 TAS2R14	1.16e-03	25	70	2	12139982
Pubmed	Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.	GJA9 NCKAP1 PIK3R1	1.20e-03	103	70	3	21706016
Pubmed	Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.	CHSY1 CHST12	1.26e-03	26	70	2	33905568
Pubmed	Molecular mechanisms of bitter and sweet taste transduction.	TAS2R16 TAS2R14	1.26e-03	26	70	2	11696554
Pubmed	Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.	TAS2R16 TAS2R14	1.36e-03	27	70	2	12581520
Pubmed	HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.	PDE1B PIK3R1	1.36e-03	27	70	2	11156964
Pubmed	MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation.	CYP11B1 MC2R	1.46e-03	28	70	2	29879378
Pubmed	Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.	TAS2R16 TAS2R14	1.46e-03	28	70	2	15744053
Pubmed	Age-dependent effects of Armc5 haploinsufficiency on adrenocortical function.	CYP11B1 MC2R	1.46e-03	28	70	2	28911199
Pubmed	An Integrative Synthetic Biology Approach to Interrogating Cellular Ubiquitin and Ufm Signaling.	MCM6 TIPRL	1.46e-03	28	70	2	32545848
Pubmed	Combined loss of the GATA4 and GATA6 transcription factors in male mice disrupts testicular development and confers adrenal-like function in the testes.	CYP11B1 MC2R	1.46e-03	28	70	2	25668066
Pubmed	An evaluation of the assembly of an approximately 15-Mb region on human chromosome 13q32-q33 linked to bipolar disorder and schizophrenia.	ABCC4 GPR18	1.57e-03	29	70	2	11991713
Pubmed	Biology, structure and mechanism of P-type ATPases.	ATP7A ATP11C	1.57e-03	29	70	2	15071553
Pubmed	Adaptive diversification of bitter taste receptor genes in Mammalian evolution.	TAS2R16 TAS2R14	1.67e-03	30	70	2	12679530
Pubmed	Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response.	CYP2D6 SOAT1	1.79e-03	31	70	2	20031551
Cytoband	13q32	ABCC4 GPR18	1.82e-04	13	71	2	13q32
GeneFamily	Solute carriers	SLC35D1 SLC9C1 SLC46A3 SLC10A5 SLC6A19 SLC2A2 SLC52A3	8.77e-05	395	49	7	752
GeneFamily	SH2 domain containing\|Suppressors of cytokine signaling	SOCS5 SOCS4	1.99e-04	8	49	2	764
GeneFamily	Olfactory receptors, family 6	OR6C4 OR6K3 OR6C65	3.56e-04	51	49	3	153
GeneFamily	SH2 domain containing	PIK3R1 SOCS5 SOCS4	2.59e-03	101	49	3	741
GeneFamily	Taste 2 receptors	TAS2R16 TAS2R14	5.00e-03	39	49	2	1162
Coexpression	LEE_LIVER_CANCER_SURVIVAL_UP	SLC35D1 DENND5B MLXIPL CYP2D6 ABCA6 SLC2A2	9.23e-06	187	68	6	M6145
Coexpression	DESCARTES_ORGANOGENESIS_HEPATOCYTES	DENND5B MLXIPL CYP2D6 ABCA6 SEC24A PXMP2 SLC2A2 GGCX DOP1B	9.72e-06	535	68	9	MM3635
Disease	fish oil supplement exposure measurement, low density lipoprotein cholesterol measurement	MLXIPL ABCA6	2.95e-05	4	66	2	EFO_0004611, EFO_0600007
Disease	Tremor, Neonatal	ATP7A CYP2D6	1.76e-04	9	66	2	C0235843
Disease	Action Tremor	ATP7A CYP2D6	1.76e-04	9	66	2	C0234376
Disease	Passive Tremor	ATP7A CYP2D6	1.76e-04	9	66	2	C0234377
Disease	Static Tremor	ATP7A CYP2D6	1.76e-04	9	66	2	C0234378
Disease	Resting Tremor	ATP7A CYP2D6	1.76e-04	9	66	2	C0234379
Disease	Intermittent Tremor	ATP7A CYP2D6	1.76e-04	9	66	2	C0234372
Disease	Fine Tremor	ATP7A CYP2D6	1.76e-04	9	66	2	C0234373
Disease	Coarse Tremor	ATP7A CYP2D6	1.76e-04	9	66	2	C0234374
Disease	Massive Tremor	ATP7A CYP2D6	1.76e-04	9	66	2	C0234375
Disease	Persistent Tremor	ATP7A CYP2D6	1.76e-04	9	66	2	C0234370
Disease	Continuous Tremor	ATP7A CYP2D6	1.76e-04	9	66	2	C0234371
Disease	Darkness Tremor	ATP7A CYP2D6	1.76e-04	9	66	2	C0234381
Disease	Involuntary Quiver	ATP7A CYP2D6	1.76e-04	9	66	2	C1527384
Disease	Tremor, Perioral	ATP7A CYP2D6	1.76e-04	9	66	2	C0235078
Disease	Nerve Tremors	ATP7A CYP2D6	1.76e-04	9	66	2	C0235083
Disease	Tremor, Limb	ATP7A CYP2D6	1.76e-04	9	66	2	C0235081
Disease	Tremor, Muscle	ATP7A CYP2D6	1.76e-04	9	66	2	C0235082
Disease	Senile Tremor	ATP7A CYP2D6	1.76e-04	9	66	2	C0149840
Disease	Saturnine Tremor	ATP7A CYP2D6	1.76e-04	9	66	2	C0040827
Disease	Pill Rolling Tremor	ATP7A CYP2D6	1.76e-04	9	66	2	C0751564
Disease	Tremor, Semirhythmic	ATP7A CYP2D6	1.76e-04	9	66	2	C0751565
Disease	Tremor	ATP7A CYP2D6	2.68e-04	11	66	2	C0040822
Disease	phospholipids:total lipids ratio, high density lipoprotein cholesterol measurement	SEMA4D MLXIPL ABCA6 MCM6 FFAR4	6.28e-04	307	66	5	EFO_0004612, EFO_0020946
Disease	low density lipoprotein cholesterol measurement, body fat percentage	EVI5 MCM6	6.56e-04	17	66	2	EFO_0004611, EFO_0007800
Disease	metabolite measurement	MLXIPL ABCC4 CYP2D6 MC2R PXMP2 MCM6	1.58e-03	560	66	6	EFO_0004725
Disease	hypertension (biomarker_via_orthology)	PIK3R1 CYP11B1 SLC6A19 CHST12	1.69e-03	227	66	4	DOID:10763 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
MTRFSLIIFFLSAPF	ERVPABLB-1	41	P60509
VFFTMDNFETSLLPF	CATSPERD	71	Q86XM0
RLTFFFLIPLFIMIG	GPR18	191	Q14330
EMFILFFLLHFSPLV	ABCA6	221	Q8N139
TPKTFLDFLDTFLML	DNHD1	3111	Q96M86
LLFAIFFFMSQVLPA	DEFB108B	6	Q8NET1
RRSFLVSLFFCIPVM	ATP7A	651	Q04656
FIFALFETIITPLTM	MFSD8	281	Q8NHS3
FLEISFTTVFIPRFL	OR6C65	66	A6NJZ3
DTAIALMFTVLAPFF	OR6K3	286	Q8NGY3
NLSAPIMSRFDLFFI	MCM6	521	Q14566
TCVDFFRLVPFMVFL	LETM2	171	Q2VYF4
QMFLFFRVLLLRISP	DOP1B	2071	Q9Y3R5
MLRFLPDLAFSFLLI	GDF3	1	Q9NR23
RLFRTLFLLMVSFFI	FFAR4	261	Q5NUL3
FFLNVPFDSIMERLT	AK8	376	Q96MA6
SFIIMFPSIFLLEHL	OR52B6	171	Q8NGF0
RFKIPTVFLMSFLDA	PDE1B	196	Q01064
TFPLPIATRIFDIFM	EVI5	331	O60447
MIAIFLFVSFFEIGP	SLC2A2	401	P11168
LFFPRFFFLSNDEML	DNAH12	991	Q6ZR08
VLISLLFIIMTFPFS	NPHS2	106	Q9NP85
FFSMVRLSPLLFLEN	PDZD3	416	Q86UT5
MSDLLFVFTLPFRIF	LPAR6	61	P43657
LMFLAPIAVSVRRFF	PGAP6	556	Q9HCN3
ARVLSEIFSPMLFRF	PIK3R1	261	P27986
FLEISFTSIFIPRFL	OR6C4	66	Q8NGE1
PKALFVFMALSFARD	NCKAP1	366	Q9Y2A7
MFESILKAPVLFFDR	ABCC4	801	O15439
MIRSATPFPLVSLFF	CACNG5	96	Q9UF02
FVSRPTEKTIFLLFM	GJA9	201	P57773
EPLARMELFLFFTSL	CYP2D6	446	P10635
SFILRPSMFPLLTFR	CYP11B1	486	P15538
PFLSRFIETQMFATF	DENND5B	556	Q6ZUT9
ERLLPFTFVGNLFMV	KHNYN	561	O15037
MVGLLLFFFPAIFLE	GRM1	1	Q13255
SPILTRLMNFFVFSR	MEST	201	Q5EB52
FSFLMTEALLVFSPE	CYB561D2	56	O14569
FIFIPFTLSLAMFLL	TAS2R14	186	Q9NYV8
VIPFILFLASTIFLM	TAS2R16	186	Q9NYV7
VVSPLLMLIIFLFFF	SLC6A19	536	Q695T7
PLIRSLFHGFLFMIF	SOAT1	216	P35610
NSLFFFLLFLRLFPM	TMEM41A	151	Q96HV5
AHFSPLVFFLLLSIM	SLC52A3	216	Q9NQ40
TFLSRIAFLMVFTFF	SLC9C1	296	Q4G0N8
MFFEPLLTISLNRTF	SOCS5	466	O75159
TDFLSFFIPTFIMII	TAAR6	201	Q96RI8
VFLFSNLSLIFLMPF	LMBR1L	116	Q6UX01
MVPFSLRLFPLFVLA	SEC24A	891	O95486
MFLARVPFLFTIVPF	SLC46A3	351	Q7Z3Q1
MFFEPLLSTPLIRTF	SOCS4	371	Q8WXH5
LVNVLFFFTPLMTLV	SMIM42	26	A0A5F9ZH02
FFALGSPIAMFLTIR	SEC23IP	786	Q9Y6Y8
SDNRLLMSLFLFFFV	SEMA4D	731	Q92854
NLPMFTVLRRFSILF	SLC35D1	131	Q9NTN3
FSILIRPLFESFNGM	MLXIPL	771	Q9NP71
FLERIIRPLSFILMF	SLC10A5	301	Q5PT55
FLTLFLSVMPFESAV	TBC1D9B	671	Q66K14
ITFTSLFPLMLVFIL	MC2R	176	Q01718
FLPFEISMAQRFLLT	CLDN34	81	H7C241
ILIPLSGRFDMFVRF	CHSY1	536	Q86X52
FLFVRDPFVRLISAF	CHST12	241	Q9NRB3
LPLRFLYIALSEMTF	LINC02915	61	Q8N8G6
DFLSFMVLFNFIIPV	ATP11C	346	Q8NB49
VTFVLQLFLFLPSMR	ZDHHC22	21	Q8N966
PFELFFMINTSILLI	TLR3	701	O15455
PASLAVFRFLFGFLM	GGCX	61	P38435
VFRFLFGFLMVLDIP	GGCX	66	P38435
SMATVELFVFLFAPL	UNC80	181	Q8N2C7
LLDRLVFAPAFLMLF	PXMP2	111	Q9NR77
KIRVMPSSFFLLLRF	TIPRL	171	O75663
PSFLSEFRALQFSLM	SPNS1	451	Q9H2V7
PVSKASLIFIFTLFM	TMEM38A	206	Q9H6F2