Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	chromatin binding	TNRC18 SFPQ PELP1 KMT5C PDX1 BRD3 RERE NONO AHDC1 RXRB	1.67e-04	739	67	10	GO:0003682
Domain	NOPS	SFPQ NONO	3.79e-05	3	67	2	PF08075
Domain	NOPS	SFPQ NONO	3.79e-05	3	67	2	IPR012975
Domain	-	RERE NR1D1 RXRB NR2F2	5.18e-05	57	67	4	3.30.50.10
Domain	Znf_NHR/GATA	RERE NR1D1 RXRB NR2F2	5.55e-05	58	67	4	IPR013088
Domain	AT_hook	PRR12 SRCAP AHDC1	1.21e-04	27	67	3	SM00384
Domain	AT_hook_DNA-bd_motif	PRR12 SRCAP AHDC1	1.21e-04	27	67	3	IPR017956
Domain	Kinase_OSR1/WNK_CCT	WNK4 WNK2	1.88e-04	6	67	2	IPR024678
Domain	OSR1_C	WNK4 WNK2	1.88e-04	6	67	2	PF12202
Domain	zf-C4	NR1D1 RXRB NR2F2	6.00e-04	46	67	3	PF00105
Domain	Znf_hrmn_rcpt	NR1D1 RXRB NR2F2	6.00e-04	46	67	3	IPR001628
Domain	Nuclear_hrmn_rcpt	NR1D1 RXRB NR2F2	6.00e-04	46	67	3	IPR001723
Domain	NUCLEAR_REC_DBD_2	NR1D1 RXRB NR2F2	6.00e-04	46	67	3	PS51030
Domain	NUCLEAR_REC_DBD_1	NR1D1 RXRB NR2F2	6.00e-04	46	67	3	PS00031
Domain	ZnF_C4	NR1D1 RXRB NR2F2	6.00e-04	46	67	3	SM00399
Domain	-	NR1D1 RXRB NR2F2	6.39e-04	47	67	3	1.10.565.10
Domain	HOLI	NR1D1 RXRB NR2F2	6.80e-04	48	67	3	SM00430
Domain	Nucl_hrmn_rcpt_lig-bd	NR1D1 RXRB NR2F2	6.80e-04	48	67	3	IPR000536
Domain	Hormone_recep	NR1D1 RXRB NR2F2	6.80e-04	48	67	3	PF00104
Domain	BAH	TNRC18 RERE	6.83e-04	11	67	2	SM00439
Domain	BAH	TNRC18 RERE	6.83e-04	11	67	2	PF01426
Domain	BAH	TNRC18 RERE	6.83e-04	11	67	2	PS51038
Domain	BAH_dom	TNRC18 RERE	6.83e-04	11	67	2	IPR001025
Domain	WH2	WASL WIPF1	1.12e-03	14	67	2	SM00246
Domain	FH2	GRID2IP DIAPH1	1.29e-03	15	67	2	PS51444
Domain	FH2_Formin	GRID2IP DIAPH1	1.29e-03	15	67	2	IPR015425
Domain	FH2	GRID2IP DIAPH1	1.29e-03	15	67	2	PF02181
Domain	FH2	GRID2IP DIAPH1	1.29e-03	15	67	2	SM00498
Domain	WH2	WASL WIPF1	1.47e-03	16	67	2	PF02205
Domain	WH2_dom	WASL WIPF1	2.55e-03	21	67	2	IPR003124
Domain	WH2	WASL WIPF1	3.33e-03	24	67	2	PS51082
Domain	RRM_1	SFPQ DAZAP1 NONO CPSF7	6.63e-03	208	67	4	PF00076
Domain	RRM	SFPQ DAZAP1 NONO CPSF7	7.68e-03	217	67	4	SM00360
Domain	RRM_dom	SFPQ DAZAP1 NONO CPSF7	8.96e-03	227	67	4	IPR000504
Domain	Ser/Thr_kinase_AS	PKMYT1 CAMK2B DCLK2 WNK4 WNK2	9.10e-03	357	67	5	IPR008271
Domain	S_TKc	PKMYT1 CAMK2B DCLK2 WNK4 WNK2	9.31e-03	359	67	5	SM00220
Domain	RRM	SFPQ DAZAP1 NONO CPSF7	9.37e-03	230	67	4	PS50102
Domain	PROTEIN_KINASE_ST	PKMYT1 CAMK2B DCLK2 WNK4 WNK2	9.63e-03	362	67	5	PS00108
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	WASL SFPQ WIPF1 DAZAP1 YLPM1 DIAPH1 RPRD2 NONO SF3A2 CPSF7	5.03e-13	154	68	10	16055720
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	WASL SFPQ DAZAP1 YLPM1 DIAPH1 RPRD2 BCL9 NONO SF3A2 CPSF7	1.76e-11	220	68	10	24550385
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PKMYT1 ANKRD13D SEMA3F PRR12 TNRC18 KMT5C FBRSL1 TSC2 BCL9 SRCAP SUFU AHDC1 CEP170B NR2F2 WNK2	2.84e-09	1105	68	15	35748872
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SFPQ PELP1 CAMK2B IQSEC2 YLPM1 SH3BP1 DIAPH1 TJAP1 TSC2 TACC3 BCL9 HCN2 CEP170B WNK2	4.36e-09	963	68	14	28671696
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	PRR12 TNRC18 YLPM1 RPRD2 RERE BCL9 AHDC1 CPSF7	5.55e-08	268	68	8	33640491
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	SFPQ DAZAP1 YLPM1 RPRD2 TACC3 NONO BAG6 SF3A2 CPSF7	8.53e-08	399	68	9	35987950
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	SFPQ KIAA1549L EFS CAMK2B TJAP1 RPRD2 TSC2 TACC3 NR1D1 NONO	1.36e-07	560	68	10	21653829
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	PRR12 SFPQ DAZAP1 YLPM1 XRN1 BCL9 NONO AHDC1 CPSF7	2.68e-07	457	68	9	32344865
Pubmed	Proline-rich sequence recognition: II. Proteomics analysis of Tsg101 ubiquitin-E2-like variant (UEV) interactions.	SFPQ NONO BAG6 CPSF7	4.61e-07	32	68	4	19542561
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	PRR12 SFPQ DAZAP1 PELP1 FBRSL1 BCL9	5.52e-07	152	68	6	38360978
Pubmed	Elevation of hsa-miR-7-5p level mediated by CtBP1-p300-AP1 complex targets ATXN1 to trigger NF-κB-dependent inflammation response.	WIPF1 DAZAP1 PELP1 SH3BP1 DIAPH1 SF3A2	1.10e-06	171	68	6	36629882
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	PRR12 SFPQ YLPM1 RPRD2 BCL9 CPSF7	1.48e-06	180	68	6	35198878
Pubmed	The structure of human SFPQ reveals a coiled-coil mediated polymer essential for functional aggregation in gene regulation.	SFPQ NONO	3.77e-06	2	68	2	25765647
Pubmed	Molecular Modelling of NONO and SFPQ Dimerization Process and RNA Recognition Mechanism.	SFPQ NONO	3.77e-06	2	68	2	35886974
Pubmed	TACC3-TSC2 maintains nuclear envelope structure and controls cell division.	TSC2 TACC3	3.77e-06	2	68	2	20237422
Pubmed	Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome.	WASL WIPF1	3.77e-06	2	68	2	12437929
Pubmed	SFPQ•NONO and XLF function separately and together to promote DNA double-strand break repair via canonical nonhomologous end joining.	SFPQ NONO	3.77e-06	2	68	2	27924002
Pubmed	Identification of the polypyrimidine tract binding protein-associated splicing factor.p54(nrb) complex as a candidate DNA double-strand break rejoining factor.	SFPQ NONO	3.77e-06	2	68	2	15590677
Pubmed	PSF and p54(nrb)/NonO--multi-functional nuclear proteins.	SFPQ NONO	3.77e-06	2	68	2	12417296
Pubmed	Purification and characterization of a DNA-binding heterodimer of 52 and 100 kDa from HeLa cells.	SFPQ NONO	3.77e-06	2	68	2	8439294
Pubmed	Invadopodia proteins, cortactin, N-WASP and WIP differentially promote local invasiveness in ameloblastoma.	WASL WIPF1	3.77e-06	2	68	2	26752341
Pubmed	The PSF.p54nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor alpha.	SFPQ NONO	3.77e-06	2	68	2	17965020
Pubmed	A critical function for the actin cytoskeleton in targeted exocytosis of prefusion vesicles during myoblast fusion.	WASL WIPF1	3.77e-06	2	68	2	17419995
Pubmed	Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA.	SFPQ NONO	3.77e-06	2	68	2	25605962
Pubmed	PSF/p54(nrb) stimulates "jumping" of DNA topoisomerase I between separate DNA helices.	SFPQ NONO	3.77e-06	2	68	2	10858305
Pubmed	PSF acts through the human immunodeficiency virus type 1 mRNA instability elements to regulate virus expression.	SFPQ NONO	3.77e-06	2	68	2	12944487
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	SFPQ DAZAP1 PELP1 XRN1 RPRD2 NONO CPSF7	4.66e-06	340	68	7	24332808
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	SFPQ DAZAP1 YLPM1 RERE NONO CPSF7	4.72e-06	220	68	6	35785414
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	TNRC18 DAZAP1 JADE2 CAMK2B FBRSL1 TJAP1 RPRD2 DCLK2 RERE TSC22D4 AHDC1 CEP170B WNK2	5.37e-06	1489	68	13	28611215
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	PRR12 SFPQ PELP1 JADE2 BRD3 NONO AHDC1 SF3A2 NR2F2 CPSF7	5.65e-06	847	68	10	35850772
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	WASL SFPQ YLPM1 DIAPH1 RPRD2 SRCAP SF3A2 CPSF7	6.53e-06	506	68	8	30890647
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	VPS9D1 WASL DAZAP1 JADE2 IQSEC2 YLPM1 TSC2 DCLK2 BTBD1 NR1D1 DSCAML1 SF3A2	6.61e-06	1285	68	12	35914814
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	PRR12 SFPQ PELP1 YLPM1 RPRD2 BRD3 TIGD5 SRCAP NONO AHDC1 SF3A2 CPSF7	7.09e-06	1294	68	12	30804502
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	PRR12 TNRC18 SFPQ WIPF1 DAZAP1 BCL9 NONO BAG6 AHDC1 SF3A2 CPSF7	9.10e-06	1103	68	11	34189442
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	HIC1 JADE2 BRD3 TIGD5 TACC3 TSC22D4 NR1D1 RXRB NR2F2	9.74e-06	709	68	9	22988430
Pubmed	Waltzing with WASP.	WASL WIPF1	1.13e-05	3	68	2	10087612
Pubmed	P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner.	SFPQ NONO	1.13e-05	3	68	2	16148043
Pubmed	hnRNP M interacts with PSF and p54(nrb) and co-localizes within defined nuclear structures.	SFPQ NONO	1.13e-05	3	68	2	19874820
Pubmed	Starvation-induced suppression of DAZAP1 by miR-10b integrates splicing control into TSC2-regulated oncogenic autophagy in esophageal squamous cell carcinoma.	DAZAP1 TSC2	1.13e-05	3	68	2	32308763
Pubmed	Proteomic identification of a PSF/p54nrb heterodimer as RNF43 oncoprotein-interacting proteins.	SFPQ NONO	1.13e-05	3	68	2	18655028
Pubmed	Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners.	WASL NONO	1.13e-05	3	68	2	16767080
Pubmed	PSPC1, NONO, and SFPQ are expressed in mouse Sertoli cells and may function as coregulators of androgen receptor-mediated transcription.	SFPQ NONO	1.13e-05	3	68	2	16641145
Pubmed	Proteomic identification of PSF and p54(nrb) as TopBP1-interacting proteins.	SFPQ NONO	1.13e-05	3	68	2	22213094
Pubmed	WIP provides an essential link between Nck and N-WASP during Arp2/3-dependent actin polymerization.	WASL WIPF1	1.13e-05	3	68	2	23707428
Pubmed	The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.	SFPQ NONO	1.13e-05	3	68	2	15790595
Pubmed	RNF8 mediates NONO degradation following UV-induced DNA damage to properly terminate ATR-CHK1 checkpoint signaling.	SFPQ NONO	1.13e-05	3	68	2	30445466
Pubmed	The WH1 and EVH1 domains of WASP and Ena/VASP family members bind distinct sequence motifs.	WASL WIPF1	1.13e-05	3	68	2	12372256
Pubmed	Quantitative proteomics reveals dynamic interaction of c-Jun N-terminal kinase (JNK) with RNA transport granule proteins splicing factor proline- and glutamine-rich (Sfpq) and non-POU domain-containing octamer-binding protein (Nono) during neuronal differentiation.	SFPQ NONO	1.13e-05	3	68	2	25326457
Pubmed	The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination.	SFPQ NONO	1.13e-05	3	68	2	17639083
Pubmed	Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response.	SFPQ NONO	1.13e-05	3	68	2	20421735
Pubmed	Graded loss of tuberin in an allelic series of brain models of TSC correlates with survival, and biochemical, histological and behavioral features.	CTAGE1 TSC2	1.13e-05	3	68	2	22752306
Pubmed	Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma.	SFPQ NONO	1.13e-05	3	68	2	9393982
Pubmed	The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs.	SFPQ NONO	1.13e-05	3	68	2	11525732
Pubmed	Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.	WASL DAZAP1 EFS MAPK1IP1L CAMK2B NR1D1 NONO RXRB CPSF7	1.40e-05	742	68	9	26871637
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	SH3BP1 XRN1 SLC35E1 TSC2 SRCAP SF3A2	1.90e-05	281	68	6	24163370
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	PKMYT1 SFPQ PELP1 IQSEC2 SLC35E1 RERE LNPK NONO BAG6 SF3A2 CPSF7	2.04e-05	1203	68	11	29180619
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	TNRC18 PLCH2 YLPM1 BCL9 SUFU WNK4 WNK2	2.13e-05	430	68	7	35044719
Pubmed	Long noncoding RNA GAPLINC promotes invasion in colorectal cancer by targeting SNAI2 through binding with PSF and NONO.	SFPQ NONO	2.25e-05	4	68	2	27259250
Pubmed	Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms.	TACC3 RXRB	2.25e-05	4	68	2	15207008
Pubmed	WIP regulates N-WASP-mediated actin polymerization and filopodium formation.	WASL WIPF1	2.25e-05	4	68	2	11331876
Pubmed	Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed.	WNK4 WNK2	2.25e-05	4	68	2	34384519
Pubmed	Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin.	WASL WIPF1	2.25e-05	4	68	2	15684033
Pubmed	WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.	WNK4 WNK2	2.25e-05	4	68	2	11571656
Pubmed	Human hypertension caused by mutations in WNK kinases.	WNK4 WNK2	2.25e-05	4	68	2	11498583
Pubmed	Murine Long Noncoding RNA Morrbid Contributes in the Regulation of NRAS Splicing in Hepatocytes In Vitro.	SFPQ NONO	2.25e-05	4	68	2	32764370
Pubmed	The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction.	SFPQ NONO	2.25e-05	4	68	2	9756848
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	ANKRD13D KIAA1549L RERE TSC22D4 BAG6 AHDC1 WNK2 CPSF7	2.45e-05	608	68	8	16713569
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	SFPQ TSC2 BRD3 LNPK SRCAP NONO	2.74e-05	300	68	6	28561026
Pubmed	Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes.	WIPF1 YLPM1 DIAPH1	3.09e-05	31	68	3	19041431
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	SFPQ DAZAP1 YLPM1 XRN1 SLC35E1 WNK4 WNK2	3.36e-05	462	68	7	31138677
Pubmed	Transcriptional activity of androgen receptor is modulated by two RNA splicing factors, PSF and p54nrb.	SFPQ NONO	3.75e-05	5	68	2	17452459
Pubmed	Dynamic paraspeckle component localisation during spermatogenesis.	SFPQ NONO	3.75e-05	5	68	2	31299635
Pubmed	WIP modulates dendritic spine actin cytoskeleton by transcriptional control of lipid metabolic enzymes.	WASL WIPF1	3.75e-05	5	68	2	24698977
Pubmed	The mitotic phosphorylation of p54(nrb) modulates its RNA binding activity.	SFPQ NONO	3.75e-05	5	68	2	21819346
Pubmed	Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription.	SFPQ NONO	3.75e-05	5	68	2	11897684
Pubmed	Specific trans-acting proteins interact with auxiliary RNA polyadenylation elements in the COX-2 3'-UTR.	SFPQ NONO	3.75e-05	5	68	2	17507659
Pubmed	Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly.	WASL WIPF1	3.75e-05	5	68	2	22966049
Pubmed	Distinct roles of DBHS family members in the circadian transcriptional feedback loop.	SFPQ NONO	3.75e-05	5	68	2	22966205
Pubmed	NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing.	SFPQ NONO	3.75e-05	5	68	2	28846091
Pubmed	DIP/WISH-deficient mice reveal Dia- and N-WASP-interacting protein as a regulator of cytoskeletal dynamics in embryonic fibroblasts.	WASL DIAPH1	3.75e-05	5	68	2	19778379
Pubmed	A human MAP kinase interactome.	WASL SFPQ KIAA1549L WIPF1 JADE2 PTPN23 WNK2	4.63e-05	486	68	7	20936779
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	WASL PELP1 YLPM1 DIAPH1 PTPN23	4.87e-05	202	68	5	24639526
Pubmed	Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production.	SFPQ DAZAP1 NONO SF3A2 CPSF7	5.35e-05	206	68	5	22174317
Pubmed	Characterization of telomeric repeat-containing RNA (TERRA) localization and protein interactions in primordial germ cells of the mouse†.	SFPQ NONO	5.62e-05	6	68	2	30423030
Pubmed	Mouse model reveals the role of RERE in cerebellar foliation and the migration and maturation of Purkinje cells.	RERE NR2F2	5.62e-05	6	68	2	24466353
Pubmed	Wiskott-Aldrich syndrome protein is involved in alphaIIb beta3-mediated cell adhesion.	WASL WIPF1	5.62e-05	6	68	2	16582881
Pubmed	PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors.	SFPQ NONO	5.62e-05	6	68	2	11259580
Pubmed	Transcriptional activity of the murine retinol-binding protein gene is regulated by a multiprotein complex containing HMGA1, p54 nrb/NonO, protein-associated splicing factor (PSF) and steroidogenic factor 1 (SF1)/liver receptor homologue 1 (LRH-1).	SFPQ NONO	5.62e-05	6	68	2	19389484
Pubmed	Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors.	RXRB NR2F2	5.62e-05	6	68	2	7947324
Pubmed	WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters.	WNK4 WNK2	5.62e-05	6	68	2	21733846
Pubmed	Interaction network of human early embryonic transcription factors.	PRR12 TNRC18 FBRSL1 RERE BCL9 AHDC1	6.54e-05	351	68	6	38297188
Pubmed	Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.	WASL WIPF1 YLPM1 AHDC1	6.84e-05	111	68	4	22558309
Pubmed	Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.	SFPQ DAZAP1 NONO SF3A2	7.58e-05	114	68	4	31553912
Pubmed	Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.	WNK4 WNK2	7.86e-05	7	68	2	20525693
Pubmed	Malat1 is not an essential component of nuclear speckles in mice.	SFPQ NONO	7.86e-05	7	68	2	22718948
Pubmed	PSF and p54nrb bind a conserved stem in U5 snRNA.	SFPQ NONO	7.86e-05	7	68	2	12403470
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	YLPM1 XRN1 PTPN23 RPRD2 TACC3 SRCAP NONO	9.92e-05	549	68	7	38280479
Pubmed	Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts in concert with p54(nrb).	SFPQ NONO	1.05e-04	8	68	2	18042045
Pubmed	KLHL2 interacts with and ubiquitinates WNK kinases.	WNK4 WNK2	1.05e-04	8	68	2	23838290
Pubmed	Dorsal and ventral rentinoic territories defined by retinoic acid synthesis, break-down and nuclear receptor expression.	RXRB NR2F2	1.05e-04	8	68	2	10490294
Interaction	APBB1 interactions	WASL SFPQ WIPF1 YLPM1 DIAPH1 LNPK NONO SF3A2 CPSF7	1.63e-08	195	67	9	int:APBB1
Interaction	PRMT2 interactions	WASL DAZAP1 IQSEC2 YLPM1 TIGD5 BAG6 CPSF7	2.11e-08	91	67	7	int:PRMT2
Interaction	PRPF40A interactions	WASL SFPQ WIPF1 PELP1 YLPM1 DIAPH1 BRD3 NONO BAG6 SF3A2 CPSF7	2.32e-07	446	67	11	int:PRPF40A
Interaction	AR interactions	PRR12 TNRC18 SFPQ DAZAP1 PELP1 YLPM1 RPRD2 BRD3 RERE BCL9 SRCAP NONO BAG6 AHDC1 CPSF7	6.77e-07	992	67	15	int:AR
Interaction	WBP4 interactions	SFPQ WIPF1 DIAPH1 NONO SF3A2 CPSF7	1.66e-06	109	67	6	int:WBP4
Interaction	TOP3B interactions	PKMYT1 ANKRD13D SEMA3F PRR12 TNRC18 PELP1 KMT5C XRN1 FBRSL1 TSC2 BCL9 SRCAP SUFU AHDC1 CEP170B NR2F2 WNK2	4.33e-06	1470	67	17	int:TOP3B
Interaction	PIN1 interactions	PKMYT1 SSC5D SFPQ DAZAP1 EFS TSC2 TSC22D4 NONO BAG6	4.76e-06	383	67	9	int:PIN1
Interaction	ATXN1 interactions	SFPQ KIAA1549L DAZAP1 PELP1 CAMK2B DIAPH1 PTPN23 BRD3 NONO BAG6 AHDC1 SF3A2 WNK2 CPSF7	6.49e-06	1039	67	14	int:ATXN1
Interaction	ERG interactions	PRR12 SFPQ FBRSL1 BRD3 RERE BCL9 NONO	9.15e-06	223	67	7	int:ERG
Interaction	NUP35 interactions	PRR12 SFPQ DAZAP1 YLPM1 XRN1 BCL9 NONO AHDC1 CPSF7	1.08e-05	424	67	9	int:NUP35
Interaction	EYA4 interactions	PRR12 SFPQ DAZAP1 PELP1 MAPK1IP1L FBRSL1 BCL9	1.60e-05	243	67	7	int:EYA4
Interaction	EGR2 interactions	PRR12 TNRC18 FBRSL1 RERE BCL9 AHDC1	2.22e-05	171	67	6	int:EGR2
Interaction	WWOX interactions	WASL SFPQ DAZAP1 YLPM1 DIAPH1 RPRD2 BCL9 NONO SF3A2 CPSF7	3.97e-05	627	67	10	int:WWOX
Interaction	SRC interactions	WASL GRID2IP PELP1 EFS SH3BP1 DIAPH1 PTPN23 TRIM50 HCN2 NONO	6.42e-05	664	67	10	int:SRC
Interaction	GRB2 interactions	WASL KIAA1549L WIPF1 YLPM1 SH3BP1 DIAPH1 PTPN23 TSC2 HCN2 SF3A2 CPSF7	6.49e-05	806	67	11	int:GRB2
Interaction	SP7 interactions	PRR12 YLPM1 FBRSL1 RPRD2 RERE BCL9 CPSF7	6.65e-05	304	67	7	int:SP7
Interaction	ARHGAP12 interactions	PRR12 WASL YLPM1 SUFU	7.74e-05	68	67	4	int:ARHGAP12
Interaction	ACTC1 interactions	WASL SFPQ WIPF1 YLPM1 DIAPH1 RPRD2 SRCAP SF3A2 WNK2 CPSF7	9.26e-05	694	67	10	int:ACTC1
Interaction	TOP1 interactions	SFPQ KMT5C YLPM1 DIAPH1 RPRD2 BRD3 BTBD1 SRCAP NONO CPSF7	9.48e-05	696	67	10	int:TOP1
Interaction	MEN1 interactions	PRR12 SFPQ PELP1 JADE2 YLPM1 TSC2 RERE SRCAP NONO AHDC1 SF3A2 NR2F2	1.31e-04	1029	67	12	int:MEN1
Interaction	QPRT interactions	SRCAP SUFU SF3A2 CPSF7	1.76e-04	84	67	4	int:QPRT
Interaction	BICD1 interactions	WASL XRN1 PTPN23 HCN2 SUFU CEP170B	1.82e-04	250	67	6	int:BICD1
Interaction	CRX interactions	PRR12 TNRC18 FBRSL1 RERE BCL9 SUFU	1.98e-04	254	67	6	int:CRX
Interaction	GSC interactions	PRR12 TNRC18 RERE BCL9	2.02e-04	87	67	4	int:GSC
Interaction	CEP55 interactions	SFPQ MAPK1IP1L PTPN23 TACC3 BAG6 CPSF7	2.07e-04	256	67	6	int:CEP55
Interaction	NCK2 interactions	WASL WIPF1 EFS YLPM1 SF3A2 CPSF7	2.34e-04	262	67	6	int:NCK2
Interaction	TLE3 interactions	PRR12 TNRC18 FBRSL1 RERE BCL9 AHDC1 CPSF7	2.47e-04	376	67	7	int:TLE3
Interaction	PITX3 interactions	SFPQ NONO	3.01e-04	8	67	2	int:PITX3
Interaction	PSTPIP1 interactions	WASL WIPF1 KMT5C RXRB	3.06e-04	97	67	4	int:PSTPIP1
Interaction	FAM76B interactions	SFPQ KMT5C NONO CPSF7	3.31e-04	99	67	4	int:FAM76B
Interaction	ALG13 interactions	PRR12 XRN1 RERE BCL9 CPSF7	3.58e-04	183	67	5	int:ALG13
Interaction	MIR7-1 interactions	SFPQ XRN1 NONO CPSF7	3.85e-04	103	67	4	int:MIR7-1
Interaction	CTBP1 interactions	PRR12 HIC1 SFPQ DAZAP1 FBRSL1 BAG6 CPSF7	3.93e-04	406	67	7	int:CTBP1
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	PKMYT1 SFPQ YLPM1 TSC2 NONO	5.32e-05	181	41	5	694
GeneFamily	Nuclear hormone receptors	NR1D1 RXRB NR2F2	1.85e-04	49	41	3	71
GeneFamily	RNA binding motif containing	SFPQ DAZAP1 NONO CPSF7	1.35e-03	213	41	4	725
Coexpression	GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN	ANKRD13D DAZAP1 CAMK2B SH3BP1 FBRSL1 SMG9 SRCAP CPSF7	2.66e-06	338	68	8	M17094
Coexpression	KRAS.PROSTATE_UP.V1_UP	KIAA1549L CEL CAMK2B PLCH2 NALF2	2.90e-05	137	68	5	M2902
Coexpression	OCONNOR_PBMC_MENVEO_ACWYVAX_AGE_30_70YO_7DY_AFTER_SECOND_DOSE_VS_7DY_AFTER_FIRST_DOSE_UP	ANKRD13D DIAPH1 RPRD2 BRD3 LNPK	3.93e-05	146	68	5	M41190
CoexpressionAtlas	DevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#3_top-relative-expression-ranked_200	SFPQ NONO NR2F2	1.98e-05	17	67	3	gudmap_developingGonad_e16.5_epididymis_200_k3
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#3_top-relative-expression-ranked_200	SFPQ NONO NR2F2	6.57e-05	25	67	3	gudmap_developingGonad_e14.5_ epididymis_200_k3
Drug	Adamantamine fumarate [80789-67-9]; Up 200; 9.6uM; HL60; HT_HG-U133A	CEL JADE2 TACC3 NR1D1 SF3A2 CEP170B	2.65e-05	196	68	6	1344_UP
Drug	Muramic acid, N-acetyl [10597-89-4]; Up 200; 13.6uM; HL60; HT_HG-U133A	SEMA3F CEL RERE TSC22D4 SRCAP CEP170B	2.65e-05	196	68	6	1326_UP
Drug	Flecainide acetate [54143-56-5]; Down 200; 8.4uM; MCF7; HT_HG-U133A	WIPF1 RERE TSC22D4 NALF2 SF3A2 CEP170B	2.72e-05	197	68	6	3937_DN
Drug	Nifuroxazide [965-52-6]; Up 200; 14.6uM; HL60; HT_HG-U133A	VPS9D1 EGR4 CAMK2B RERE CEP170B NR2F2	2.72e-05	197	68	6	2490_UP
Drug	Hydralazine hydrochloride [304-20-1]; Down 200; 20.4uM; MCF7; HT_HG-U133A	SEMA3F WIPF1 CAMK2B TSC22D4 NR1D1 SF3A2	2.80e-05	198	68	6	3621_DN
Drug	Flumequine [42835-25-6]; Down 200; 15.4uM; MCF7; HT_HG-U133A	JADE2 CAMK2B TSC22D4 SRCAP AHDC1 CPSF7	2.80e-05	198	68	6	2276_DN
Drug	Cyclopenthiazide [742-20-1]; Down 200; 10.6uM; HL60; HT_HG-U133A	SEMA3F RERE TSC22D4 SRCAP SF3A2 NR2F2	2.97e-05	200	68	6	2905_DN
Disease	pseudohypoaldosteronism (implicated_via_orthology)	WNK4 WNK2	7.57e-05	6	67	2	DOID:4479 (implicated_via_orthology)
Disease	MiT family translocation renal cell carcinoma	SFPQ NONO	1.06e-04	7	67	2	C4518356
Disease	Childhood Medulloblastoma	HIC1 BRD3 SUFU	1.29e-04	43	67	3	C0278510
Disease	Melanotic medulloblastoma	HIC1 BRD3 SUFU	1.29e-04	43	67	3	C1275668
Disease	Medullomyoblastoma	HIC1 BRD3 SUFU	1.29e-04	43	67	3	C0205833
Disease	Desmoplastic Medulloblastoma	HIC1 BRD3 SUFU	1.29e-04	43	67	3	C0751291
Disease	Adult Medulloblastoma	HIC1 BRD3 SUFU	1.29e-04	43	67	3	C0278876
Disease	Medulloblastoma	HIC1 BRD3 SUFU	2.03e-04	50	67	3	C0025149
Disease	medulloblastoma (is_implicated_in)	TSC2 SUFU	2.26e-04	10	67	2	DOID:0050902 (is_implicated_in)
Disease	tumor necrosis factor receptor superfamily member EDAR measurement	BRD3 SUFU	3.30e-04	12	67	2	EFO_0008310
Disease	Maturity onset diabetes mellitus in young	CEL PDX1	4.54e-04	14	67	2	C0342276
Disease	osteoarthritis	GRID2IP CAMK2B RPRD2 RXRB	1.65e-03	222	67	4	MONDO_0005178
Disease	glomerular filtration rate, response to platinum based chemotherapy	RERE BCL9	1.85e-03	28	67	2	EFO_0004647, EFO_0005208
Disease	brain connectivity measurement	SEMA3F RPRD2 DCLK2 RERE WNK2	2.17e-03	400	67	5	EFO_0005210

Protein segments in the cluster

Peptide	Gene	Start	Entry
PLVTAAGPPTPPGPP	FBRSL1	1001	Q9HCM7
GIPATPGPVNPPPPE	BRD3	11	Q15059
GSPPRTPPAPGPPSF	ANKRD13D	551	Q6ZTN6
PPFPPPPPGTVFGAS	CTAGE1	686	Q96RT6
GAPPPGPAPPPATSH	BAG6	426	P46379
SPPAPPLPPGSGSPG	SH3BP1	586	Q9Y3L3
PPPALPGPGPVSVPE	AHDC1	436	Q5TGY3
TPHGTSPVGPPTPPP	CEP170B	531	Q9Y4F5
PPPPPLPGGVCISSP	DIAPH1	616	O60610
PSSLPGGTAIPPPPP	DIAPH1	666	O60610
PVPPTGDSGAPPVPP	CEL	581	P19835
PPVPPTGDSGAPPVP	CEL	591	P19835
PVPPTGDSGAPPVPP	CEL	636	P19835
PPVPPTGDSGAPPVP	CEL	646	P19835
GAPPVPPTGDAGPPP	CEL	666	P19835
PPTGDAGPPPVPPTG	CEL	671	P19835
PPGVPPPPATPGAAP	DAZAP1	306	Q96EP5
PPLSSSFGVPPPPPG	CPSF7	246	Q8N684
APPVPGPPPGAPHTP	NR2F2	26	P24468
SGALPFPSPGPPQPP	PTPN23	1031	Q9H3S7
MPPAPVPAGTPAPPG	NONO	401	Q15233
PAPPATPAPAGTPGP	KMT5C	411	Q86Y97
SPVGPPPPPAAEPPS	HIC1	191	Q14526
PAPPGPLPPAPNSGT	IQSEC2	656	Q5JU85
PESPTPHPPPAAPGG	DCLK2	741	Q8N568
PPPPPPQDGPGSRTT	JADE2	606	Q9NQC1
PPPPGGAVPPAAPVA	PDX1	241	P52945
EHTPPGPGPPGPCPT	FAM214B	226	Q7L5A3
GSPPPPVPPRTGPVA	KIAA1549L	1636	Q6ZVL6
PPPPGEPSAPPGTCG	NALF2	101	O75949
PGSSGVAAPPVPPPP	EGR4	436	Q05215
PPPSGATPPPIAPTG	PELP1	801	Q8IZL8
PTQHPTPGPMGPSPP	NR1D1	241	P20393
GPSPPPAPVPSPLVG	NR1D1	251	P20393
PQPGPGPICPDSPPS	GRID2IP	641	A4D2P6
PVPALGPVPGPSVTP	C16orf96	346	A6NNT2
MPAPPAGTAPPAPGP	DSCAML1	1976	Q8TD84
GPAGPPPPPSPSSLG	BTBD1	21	Q9H0C5
PPPPPVSSGEPPTLG	BCL9	331	O00512
PPPAPQPGPGATPAL	F8A1;	226	P23610
PTSGPPAGPCPPSPD	EFS	111	O43281
PSPPSPGPETPPAGV	C1orf127	216	Q8N9H9
PPPPGEHSGIPFPTP	RPRD2	1256	Q5VT52
GVPFSTPPPPPPPVD	RPRD2	1286	Q5VT52
GESPGATPAPGPPPP	HCN2	11	Q9UL51
PYPAPTVPGPGPTGP	MAPK1IP1L	101	Q8NDC0
GPSPVGPPPCPSPTI	CAMK2B	511	Q13554
PPPGVPAPGGPPLST	TACC3	616	Q9Y6A5
SMSAPPPPGAGPPTP	SEMA3F	711	Q13275
GASDPPTPQPPTGPP	TSC22D4	26	Q9Y3Q8
VPPPSAGPGPSPPAR	FOXE3	201	Q13461
GTAPPPPAAPAPPKG	SMG9	121	Q9H0W8
PGGPPPITPPTCPST	RERE	1041	Q9P2R6
GPPLAPAAAVPGPPP	PRR12	1421	Q9ULL5
RVPPAPPVSGPGPSP	SLC35E1	81	Q96K37
PPPGPELSAQPTPGP	SRCAP	1026	Q6ZRS2
TPSPGPSASPGPPGP	SSC5D	1006	A1L4H1
PTGPAPSGPPGPPQL	SF3A2	266	Q15428
PPPAPPGFSGPVSSP	RXRB	146	P28702
TTPPQAGGPPPPPAA	SFPQ	176	P23246
PPPPAGSVSPSPGPH	TEX44	236	Q53QW1
PGDPASPPAPGSPTP	TJAP1	271	Q5JTD0
PPKGPPAPPAATPAG	TNRC18	341	O15417
PLGPPATPPGSPPCS	PKMYT1	406	Q99640
APGPGPPPPAAVPTS	PLCH2	1011	O75038
APRPGPPAGTPPPTA	MOSPD3	151	O75425
GPTAPPAPGPTAPPA	SUFU	11	Q9UMX1
VPPGTIPPAFPPPTG	XRN1	1526	Q8IZH2
SPVPGTPGTPSPPPA	SMTNL2	91	Q2TAL5
TPGTPSPPPAPGVPD	SMTNL2	96	Q2TAL5
VPGGPRQPSPGPTPP	WIPF1	206	O43516
SATPPPGIPPPGVPQ	YLPM1	626	P49750
SGPPPPPPSVLGVGP	WASL	356	O00401
PPPSVLGVGPVAPPP	WASL	361	O00401
PTPPLQPGPVGSPSP	VPS9D1	351	Q9Y2B5
PPPSTPMPTGPGQPA	WNK2	711	Q9Y3S1
GPPAPSPAPGPPVKE	TIGD5	191	Q53EQ6
PPPSGPGPLSPEQPT	TRIM50	471	Q86XT4
EPGPPPATVPMAPGP	WNK4	536	Q96J92
GPLSPPTGPPGPAPA	TSC2	661	P49815
GPPPQVPVSPGPPKD	LNPK	186	Q9C0E8