Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	ARM-type_fold	RELCH BTAF1 WAPL RTTN LRRK2 EIF4G2	4.21e-05	339	36	6	IPR016024
Domain	Quino_amine_DH_bsu	TEP1 LRRK2	8.14e-04	22	36	2	IPR011044
Domain	-	RELCH BTAF1 RTTN LRRK2	8.49e-04	222	36	4	1.25.10.10
Domain	tRNA-bd_arm	DSP PPFIA2	9.71e-04	24	36	2	IPR010978
Domain	Spectrin_repeat	DSP SPTAN1	1.42e-03	29	36	2	IPR002017
Domain	Spectrin/alpha-actinin	DSP SPTAN1	1.73e-03	32	36	2	IPR018159
Domain	SPEC	DSP SPTAN1	1.73e-03	32	36	2	SM00150
Domain	ARM-like	RELCH BTAF1 RTTN LRRK2	1.75e-03	270	36	4	IPR011989
Domain	P-loop_NTPase	MCM7 BTAF1 TEP1 KIF17 NUBP2 LRRK2	5.22e-03	848	36	6	IPR027417
Domain	LRR	PPP1R37 AMIGO3 LRRK2	6.75e-03	201	36	3	PS51450
Domain	HEAT_REPEAT	RELCH BTAF1	8.03e-03	70	36	2	PS50077
Pubmed	Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17.	KIF17 CNGB1	6.60e-06	4	37	2	16782012
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	JAK1 LRPAP1 CAVIN3 BTAF1 HERC2 NUBP2 RTTN	9.41e-06	719	37	7	35337019
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	NAA35 HERC2 DSP DNAJC3 TUB SPTAN1	1.02e-05	475	37	6	31040226
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	RELCH WAPL DSP TBC1D9	2.99e-05	167	37	4	25659891
Pubmed	BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein.	RELCH TEP1 LRRK2	3.12e-05	57	37	3	27433848
Pubmed	The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.	HERC2 LRRK2	4.93e-05	10	37	2	26355680
Pubmed	Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.	JAK1 MCM7 HERC2 LUC7L2 SPTAN1	5.15e-05	383	37	5	29331416
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	JAK1 LRPAP1 NAA35 GOPC DSP DNAJC3 SPTAN1 CALCOCO1	5.38e-05	1297	37	8	33545068
Pubmed	Specificity of sensory-motor connections encoded by Sema3e-Plxnd1 recognition.	SLC17A7 SEMA3E	6.02e-05	11	37	2	19421194
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	RELCH MCM7 DSP LUC7L2 EIF4G2	6.25e-05	399	37	5	37536630
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	JAK1 BTAF1 HERC2 RMND1 DSP TBC1D9	6.27e-05	657	37	6	36180527
Pubmed	The histone methyltransferase SUV420H2 and Heterochromatin Proteins HP1 interact but show different dynamic behaviours.	MCM7 TUB	7.22e-05	12	37	2	19486527
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	PPP1R37 MCM7 NAA35 WAPL HERC2 DSP SPTAN1 EIF4G2	7.24e-05	1353	37	8	29467282
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	JAK1 WAPL HERC2 RMND1	7.57e-05	212	37	4	33853758
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	MCM7 CAVIN3 DSP LUC7L2 FRG1 SPTAN1 NUBP2 EIF4G2	9.90e-05	1415	37	8	28515276
Pubmed	TRIM30 modulates Interleukin-22-regulated papillary thyroid Cancer cell migration and invasion by targeting Sox17 for K48-linked Polyubiquitination.	SOX17 DSP	1.31e-04	16	37	2	31823782
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	BTAF1 WAPL DSP SPTAN1 TBC1D9 EIF4G2	1.54e-04	774	37	6	15302935
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	BTAF1 WAPL DSP SPTAN1	1.97e-04	272	37	4	31010829
Pubmed	mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking.	SLC17A7 PPFIA2	2.07e-04	20	37	2	23791195
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	MCM7 WAPL GOPC SPTAN1 EIF4G2	2.52e-04	538	37	5	28524877
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	KIF17 LUC7L2 PPFIA2 TBC1D9 CALCOCO1	3.03e-04	560	37	5	21653829
Pubmed	NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.	DSP SPTAN1	3.25e-04	25	37	2	30309841
Pubmed	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.	JAK1 SPTAN1	3.25e-04	25	37	2	8493579
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	JAK1 LRPAP1 WAPL HERC2 DSP SPTAN1 EIF4G2	3.60e-04	1285	37	7	35914814
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	BTAF1 WAPL DSP LUC7L2 SPTAN1	3.61e-04	582	37	5	20467437
Pubmed	Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction.	RELCH DSP SPTAN1	3.69e-04	131	37	3	28634551
Pubmed	NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.	DSP CNGB1 SPTAN1 CALCOCO1	4.25e-04	333	37	4	32665550
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	JAK1 BTAF1 WAPL FRG1	4.65e-04	341	37	4	32971831
Pubmed	E3 Ubiquitin Ligase UBR5 Promotes the Metastasis of Pancreatic Cancer via Destabilizing F-Actin Capping Protein CAPZA1.	DSP SPTAN1	5.02e-04	31	37	2	33777788
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	LUC7L2 PPFIA2 SPTAN1	5.59e-04	151	37	3	17043677
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	MCM7 DSP SPTAN1 RTTN EIF4G2	5.60e-04	641	37	5	36057605
Pubmed	Linking nuclear matrix-localized PIAS1 to chromatin SUMOylation via direct binding of histones H3 and H2A.Z.	MCM7 DSP SPTAN1	6.50e-04	159	37	3	34537242
Pubmed	Reverse engineering a mouse embryonic stem cell-specific transcriptional network reveals a new modulator of neuronal differentiation.	SLC17A7 SPTAN1	7.16e-04	37	37	2	23180766
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PPP1R37 RELCH HERC2 GOPC DSP SPTAN1	7.75e-04	1049	37	6	27880917
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	LRPAP1 NAA35 HERC2 GOPC DNAJC3 SPTAN1 EIF4G2	8.59e-04	1487	37	7	33957083
Pubmed	Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.	MCM7 DSP SPTAN1	9.61e-04	182	37	3	26527279
Pubmed	Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.	BTAF1 EIF4G2	9.67e-04	43	37	2	34672947
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	BTAF1 HERC2 IL1RAPL2 EIF4G2	1.01e-03	420	37	4	28065597
Interaction	TTC3 interactions	JAK1 LRPAP1 WAPL HERC2 DSP SPTAN1 EIF4G2	2.49e-09	124	37	7	int:TTC3
Interaction	STK24 interactions	MCM7 DSP LUC7L2 TBC1D9 LRRK2	1.33e-05	168	37	5	int:STK24
Interaction	H3C1 interactions	MCM7 WAPL DSP DNAJC3 LUC7L2 FRG1 SPTAN1 TAF1A LRRK2	2.75e-05	901	37	9	int:H3C1
GeneFamily	Immunoglobulin like domain containing	AMIGO3 IL1RAPL2 SEMA3E	2.05e-03	193	24	3	594
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	PPP1R37 MCM7	2.38e-02	181	24	2	694
Disease	sciatic neuropathy (biomarker_via_orthology)	JAK1 SLC17A7 AMIGO3	2.62e-04	99	37	3	DOID:11446 (biomarker_via_orthology)
Disease	transient cerebral ischemia (biomarker_via_orthology)	JAK1 SLC17A7 SEMA3E	1.01e-03	157	37	3	DOID:224 (biomarker_via_orthology)
Disease	left ventricular systolic function measurement	TUB LUC7L2	1.40e-03	44	37	2	EFO_0008206
Disease	hepatocellular carcinoma (is_implicated_in)	JAK1 MCM7 TEP1	1.51e-03	181	37	3	DOID:684 (is_implicated_in)
Disease	stomach cancer (is_implicated_in)	JAK1 TEP1	3.70e-03	72	37	2	DOID:10534 (is_implicated_in)
Disease	asthma, response to diisocyanate	CAVIN3 HERC2 LUC7L2	4.26e-03	261	37	3	EFO_0006995, MONDO_0004979

Protein segments in the cluster

Peptide	Gene	Start	Entry
LVARGKLHVLLFKEE	CAVIN3	116	Q969G5
RHDLDGLGALEKLLL	AMIGO3	126	Q86WK7
REKHALLEGRTKELG	LRPAP1	321	P30533
RGHLLLKQGKLDEAE	DNAJC3	111	Q13217
ALALRHAGKKVGILD	NUBP2	36	Q9Y5Y2
EKRFLKRIRDLGEGH	JAK1	871	P23458
IRKVLLLKEDHEGLG	GOPC	286	Q9HD26
LNKIEKLLREGEHGL	RELCH	726	Q9P260
KLLREGEHGLDEHKL	RELCH	731	Q9P260
VGKVIKLDRDGLHDL	HERC2	2591	O95714
LLDERGHLKLTDFGL	RSKR	236	Q96LW2
LGPIFDHEDLLKRKR	LRRK2	936	Q5S007
IKFIGELGKLDLIHE	EIF4G2	211	P78344
GHEDVKKALLLLLVG	MCM7	346	P33993
GHRLDCLDLKGEKLD	PPP1R37	106	O75864
LKKARKDGFLHETLL	FRG1	231	Q14331
LKAKERHFLEQLLDG	BTAF1	1236	O14981
KELIEKGHGIRLLEA	DSP	2356	P15924
GELKTELLGLKERKH	BRAWNIN	46	Q69YU5
NGRLAELGLHLKEEK	CALCOCO1	391	Q9P1Z2
KHELLEEARRKGLPF	PPFIA2	881	O75334
GGKLHLGFIEIREKL	LUC7L2	211	Q9Y383
RGKDHLRAGKLNLVD	KIF17	226	Q9P2E2
LLKLAFGDGKHRLAL	RTTN	236	Q86VV8
KRLKRVEGGFLHGLA	SOX17	146	Q9H6I2
EKEEHRKLGLEVLFG	TAF1A	321	Q15573
REGEIRLLKEHLGEK	IL1RAPL2	296	Q9NP60
KLHRGEIKLNSELDL	RMND1	281	Q9NWS8
EEFRKLAGRALGKLH	SLC17A7	6	Q9P2U7
LGKLHRLLEKRQEGA	SLC17A7	16	Q9P2U7
LEEHLILKELAARGK	SLFNL1	116	Q499Z3
GGKLAHLRARLKELA	CNGB1	1126	Q14028
DGHFLILAKADLKLL	TEP1	2381	Q99973
RELKLGELLHDKLFG	NAA35	41	Q5VZE5
ELYHSLLELGEKRKG	SPTAN1	1071	Q13813
RALFRLPKDEKLDGH	TBC1D9	296	Q6ZT07
FKEELRLLGGLDHIV	WAPL	811	Q7Z5K2
FEILGFDILLDHKLK	TTLL6	341	Q8N841
DLGLLFLRLHKSDAG	SEMA3E	636	O15041
LHLDREDGKKVFLLA	TUB	286	P50607