Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SP8 SP4 ZNF492 HIF1A ZNF716 ZNF486 SP6 ZNF816 ZNF814 SP9 E4F1 REST ZNF700 ZNF98 ZNF714 ZBTB24 ZNF441 ZNF587B ZFY ZIC1 ZNF710 ZIC2 ZIC3	7.41e-13	1459	54	23	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	SP8 SP4 ZNF492 HIF1A ZNF716 ZNF486 SP6 ZNF816 ZNF814 SP9 E4F1 REST ZNF700 ZNF98 ZNF714 ZBTB24 ZNF441 ZNF587B ZFY ZIC1 ZIC2 ZIC3	3.61e-12	1412	54	22	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SP8 SP4 ZNF492 HIF1A ZNF716 ZNF486 SP6 ZNF816 ZNF814 SP9 E4F1 REST ZNF98 ZNF714 ZBTB24 ZFY ZIC1 ZNF710 ZIC2 ZIC3	2.80e-11	1244	54	20	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	SP8 SP4 ZNF492 HIF1A ZNF716 ZNF486 SP6 ZNF816 ZNF814 SP9 E4F1 REST ZNF98 ZNF714 ZBTB24 ZFY ZIC1 ZNF710 ZIC2 ZIC3	4.12e-11	1271	54	20	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	HIF1A ZNF814 E4F1 ZFY ZIC1 ZIC2 ZIC3	7.43e-04	560	54	7	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	HIF1A ZNF814 E4F1 ZFY ZIC1 ZIC2 ZIC3	7.91e-04	566	54	7	GO:0001216
GeneOntologyBiologicalProcess	embryo development	SP8 HIF1A SUPT20H CEP290 RCN1 PSMC4 SP9 E4F1 REST ZFY ZIC1 ZIC2 ZIC3	6.46e-05	1437	54	13	GO:0009790
GeneOntologyBiologicalProcess	central nervous system segmentation	ZIC2 ZIC3	6.69e-05	5	54	2	GO:0035283
GeneOntologyBiologicalProcess	embryonic morphogenesis	SP8 HIF1A SUPT20H CEP290 SP9 REST ZIC1 ZIC2 ZIC3	8.84e-05	713	54	9	GO:0048598
HumanPheno	Ectopic anus	UBR1 SETBP1 ZIC2 ZIC3	6.56e-05	93	13	4	HP:0004397
HumanPheno	Sloping forehead	DMXL2 SETBP1 CEP290 KIF14 ZIC2	6.56e-05	188	13	5	HP:0000340
HumanPheno	Abnormal neural tube morphology	SETBP1 CEP290 KIF14 ZIC1 ZIC2 ZIC3	7.41e-05	324	13	6	HP:0410043
HumanPheno	Neural tube defect	SETBP1 CEP290 KIF14 ZIC1 ZIC2 ZIC3	7.41e-05	324	13	6	HP:0045005
HumanPheno	Slanting of the palpebral fissure	UBR1 DMXL2 ABAT SETBP1 CEP290 KIF14 ZIC1 ZIC2	1.24e-04	739	13	8	HP:0200006
Domain	-	SP8 SP4 ZNF492 ZNF716 ZNF486 SP6 ZNF816 ZNF814 SP9 ZNF407 ZNF488 E4F1 REST ZNF700 ZNF98 ZNF714 ZBTB24 ZNF441 ZNF587B ZFY ZIC1 ZNF710 ZIC2 ZIC3	1.74e-21	679	51	24	3.30.160.60
Domain	zf-C2H2	SP8 SP4 ZNF492 ZNF716 ZNF486 SP6 ZNF816 ZNF814 SP9 ZNF407 ZNF488 E4F1 REST ZNF700 ZNF98 ZNF714 ZBTB24 ZNF441 ZNF587B ZFY ZIC1 ZNF710 ZIC2 ZIC3	2.80e-21	693	51	24	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	SP8 SP4 ZNF492 ZNF716 ZNF486 SP6 ZNF816 ZNF814 SP9 ZNF407 ZNF488 E4F1 REST ZNF700 ZNF98 ZNF714 ZBTB24 ZNF441 ZNF587B ZFY ZIC1 ZNF710 ZIC2 ZIC3	2.90e-21	694	51	24	IPR013087
Domain	Znf_C2H2-like	SP8 SP4 ZNF492 ZNF716 ZNF486 SP6 ZNF816 ZNF814 SP9 ZNF407 ZNF488 ZNF318 E4F1 REST ZNF700 ZNF98 ZNF714 ZBTB24 ZNF441 ZNF587B ZFY ZIC1 ZNF710 ZIC2 ZIC3	3.30e-21	796	51	25	IPR015880
Domain	ZnF_C2H2	SP8 SP4 ZNF492 ZNF716 ZNF486 SP6 ZNF816 ZNF814 SP9 ZNF407 ZNF488 ZNF318 E4F1 REST ZNF700 ZNF98 ZNF714 ZBTB24 ZNF441 ZNF587B ZFY ZIC1 ZNF710 ZIC2 ZIC3	4.74e-21	808	51	25	SM00355
Domain	ZINC_FINGER_C2H2_2	SP8 SP4 ZNF492 ZNF716 ZNF486 SP6 ZNF816 ZNF814 SP9 ZNF407 ZNF488 E4F1 REST ZNF700 ZNF98 ZNF714 ZBTB24 ZNF441 ZNF587B ZFY ZIC1 ZNF710 ZIC2 ZIC3	3.81e-20	775	51	24	PS50157
Domain	ZINC_FINGER_C2H2_1	SP8 SP4 ZNF492 ZNF716 ZNF486 SP6 ZNF816 ZNF814 SP9 ZNF407 ZNF488 E4F1 REST ZNF700 ZNF98 ZNF714 ZBTB24 ZNF441 ZNF587B ZFY ZIC1 ZNF710 ZIC2 ZIC3	4.04e-20	777	51	24	PS00028
Domain	Znf_C2H2	SP8 SP4 ZNF492 ZNF716 ZNF486 SP6 ZNF816 ZNF814 SP9 ZNF407 ZNF488 E4F1 REST ZNF700 ZNF98 ZNF714 ZBTB24 ZNF441 ZNF587B ZFY ZIC1 ZNF710 ZIC2 ZIC3	9.20e-20	805	51	24	IPR007087
Domain	Sp1_fam	SP8 SP4 SP6 SP9	1.02e-08	10	51	4	IPR030450
Domain	zf-C2H2_6	ZNF492 ZNF486 ZNF816 ZNF814 E4F1 ZNF700 ZNF98 ZNF714 ZBTB24 ZNF710	1.09e-08	314	51	10	PF13912
Domain	KRAB	ZNF492 ZNF716 ZNF486 ZNF816 ZNF814 ZNF700 ZNF98 ZNF714 ZNF441 ZNF587B	3.75e-08	358	51	10	PS50805
Domain	KRAB	ZNF492 ZNF716 ZNF486 ZNF816 ZNF814 ZNF700 ZNF98 ZNF714 ZNF441 ZNF587B	4.99e-08	369	51	10	SM00349
Domain	KRAB	ZNF492 ZNF716 ZNF486 ZNF816 ZNF814 ZNF700 ZNF98 ZNF714 ZNF441 ZNF587B	5.12e-08	370	51	10	IPR001909
Domain	KRAB	ZNF492 ZNF716 ZNF486 ZNF816 ZNF814 ZNF700 ZNF98 ZNF441 ZNF587B	4.73e-07	358	51	9	PF01352
Domain	AT_hook	SETBP1 ZBTB24	8.56e-04	16	51	2	PF02178
Domain	AT_hook	SETBP1 ZBTB24	2.46e-03	27	51	2	SM00384
Domain	AT_hook_DNA-bd_motif	SETBP1 ZBTB24	2.46e-03	27	51	2	IPR017956
Domain	ZnF_U1	ZNF407 ZNF318	2.83e-03	29	51	2	SM00451
Domain	Znf_U1	ZNF407 ZNF318	2.83e-03	29	51	2	IPR003604
Domain	HMGI/Y_DNA-bd_CS	SETBP1 ZBTB24	3.23e-03	31	51	2	IPR000637
Domain	PTPc	PTPRE PTPN21	4.34e-03	36	51	2	SM00194
Domain	TYR_PHOSPHATASE_PTP	PTPRE PTPN21	5.08e-03	39	51	2	PS50055
Domain	PTPase_domain	PTPRE PTPN21	5.60e-03	41	51	2	IPR000242
Domain	Y_phosphatase	PTPRE PTPN21	5.60e-03	41	51	2	PF00102
Domain	PTPc_motif	PTPRE PTPN21	1.13e-02	59	51	2	SM00404
Domain	Tyr_Pase_cat	PTPRE PTPN21	1.13e-02	59	51	2	IPR003595
Pubmed	The role of Zic family zinc finger transcription factors in the proliferation and differentiation of retinal progenitor cells.	ZIC1 ZIC2 ZIC3	3.74e-09	3	55	3	22024047
Pubmed	Genetic variants in ZIC1, ZIC2, and ZIC3 are not major risk factors for neural tube defects in humans.	ZIC1 ZIC2 ZIC3	3.74e-09	3	55	3	14679585
Pubmed	Overlapping and distinct expression domains of Zic2 and Zic3 during mouse gastrulation.	ZIC1 ZIC2 ZIC3	3.74e-09	3	55	3	15261827
Pubmed	The mouse zic gene family. Homologues of the Drosophila pair-rule gene odd-paired.	ZIC1 ZIC2 ZIC3	3.74e-09	3	55	3	8557628
Pubmed	Zic4, a zinc-finger transcription factor, is expressed in the developing mouse nervous system.	ZIC1 ZIC2 ZIC3	1.50e-08	4	55	3	15895369
Pubmed	Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins.	ZIC1 ZIC2 ZIC3	1.50e-08	4	55	3	11053430
Pubmed	A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells.	ZIC1 ZIC2 ZIC3	1.50e-08	4	55	3	7931345
Pubmed	An Evolutionarily Conserved Mesodermal Enhancer in Vertebrate Zic3.	ZIC1 ZIC2 ZIC3	1.50e-08	4	55	3	30297839
Pubmed	Myogenic repressor I-mfa interferes with the function of Zic family proteins.	ZIC1 ZIC2 ZIC3	3.73e-08	5	55	3	15207726
Pubmed	Mammalian SP/KLF transcription factors: bring in the family.	SP8 SP4 SP6 SP9	6.91e-08	25	55	4	15820306
Pubmed	Physical and functional interactions between Zic and Gli proteins.	ZIC1 ZIC2 ZIC3	7.46e-08	6	55	3	11238441
Pubmed	The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development.	SP8 SP9 ZIC1 ZIC3	1.11e-07	28	55	4	32868762
Pubmed	Zic2 patterns binocular vision by specifying the uncrossed retinal projection.	ZIC1 ZIC2 ZIC3	1.30e-07	7	55	3	13678579
Pubmed	A census of human transcription factors: function, expression and evolution.	SP4 HIF1A SETBP1 SP6 SP9 E4F1 REST ZBTB24 ZFY ZIC1 ZIC2	1.52e-07	908	55	11	19274049
Pubmed	The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation.	ZIC1 ZIC2 ZIC3	2.08e-07	8	55	3	9070329
Pubmed	Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning.	SP8 SP6 SP9	3.12e-07	9	55	3	17509151
Pubmed	Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives.	ZIC1 ZIC2 ZIC3	4.46e-07	10	55	3	15136147
Pubmed	CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA.	ZIC1 ZIC2 ZIC3	4.46e-07	10	55	3	18298960
Pubmed	A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis.	ZIC1 ZIC2 ZIC3	4.46e-07	10	55	3	21211521
Pubmed	Spatiotemporal expression of Zic genes during vertebrate inner ear development.	ZIC1 ZIC2 ZIC3	4.46e-07	10	55	3	23606270
Pubmed	Fibroblast growth factor 8 organizes the neocortical area map and regulates sensory map topography.	ZIC1 ZIC2 ZIC3	6.12e-07	11	55	3	22623663
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	SP8 HIF1A ZNF407 E4F1 REST ZNF714 ZBTB24 ZFY ZIC1 ZIC2	1.03e-06	877	55	10	20211142
Pubmed	Transcription factors Zic1 and Zic2 bind and transactivate the apolipoprotein E gene promoter.	ZIC1 ZIC2	2.46e-06	2	55	2	11038359
Pubmed	Zic-Proteins Are Repressors of Dopaminergic Forebrain Fate in Mice and C. elegans.	ZIC1 ZIC2	2.46e-06	2	55	2	28972122
Pubmed	Lack of association between ZIC2 and ZIC3 genes and the risk of neural tube defects (NTDs) in Hispanic populations.	ZIC2 ZIC3	2.46e-06	2	55	2	12522805
Pubmed	Behavioral abnormalities of Zic1 and Zic2 mutant mice: implications as models for human neurological disorders.	ZIC1 ZIC2	2.46e-06	2	55	2	11699604
Pubmed	ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency.	ZIC2 ZIC3	2.46e-06	2	55	2	39358345
Pubmed	REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia.	HIF1A REST	2.46e-06	2	55	2	26647819
Pubmed	Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum.	ZIC1 ZIC2	2.46e-06	2	55	2	25849986
Pubmed	Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo.	ZIC1 ZIC2 ZIC3	3.00e-06	18	55	3	17490632
Pubmed	Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly.	ZIC1 ZIC2 ZIC3	5.64e-06	22	55	3	18448648
Pubmed	Genome-wide association with select biomarker traits in the Framingham Heart Study.	HIF1A PTPRE UNC13C	6.48e-06	23	55	3	17903293
Pubmed	Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets.	ZIC1 ZIC2	7.36e-06	3	55	2	20676059
Pubmed	Long Noncoding RNA CASC2 Facilitated Wound Healing through miRNA-155/HIF-1α in Diabetic Foot Ulcers.	HIF1A CASC2	7.36e-06	3	55	2	35845734
Pubmed	Expression of ZIC family genes in meningiomas and other brain tumors.	ZIC1 ZIC2	7.36e-06	3	55	2	20199689
Pubmed	Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitors.	ZIC1 ZIC2 ZIC3	8.40e-06	25	55	3	17507568
Pubmed	SUMOylation Potentiates ZIC Protein Activity to Influence Murine Neural Crest Cell Specification.	ZIC2 ZIC3	1.47e-05	4	55	2	34638777
Pubmed	MIR448 antagomir reduces arrhythmic risk after myocardial infarction by upregulating the cardiac sodium channel.	HIF1A REST	1.47e-05	4	55	2	33108349
Pubmed	Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1alpha/Sp4.	SP4 HIF1A	1.47e-05	4	55	2	19934275
Pubmed	Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos.	SP8 SP9	2.45e-05	5	55	2	15358670
Pubmed	Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family.	ZIC1 ZIC2	3.67e-05	6	55	2	15465018
Pubmed	Identification of genes expressed preferentially in the developing peripheral margin of the optic cup.	REST ZIC1 ZIC2	4.11e-05	42	55	3	19449303
Pubmed	Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors.	ZIC2 ZIC3	5.13e-05	7	55	2	35817961
Pubmed	Distribution of a reeler gene-related antigen in the developing cerebellum: an immunohistochemical study with an allogeneic antibody CR-50 on normal and reeler mice.	ZIC1 ZIC3	5.13e-05	7	55	2	8863127
Pubmed	Identification of reference genes suitable for RT-qPCR studies of murine gastrulation and patterning.	ZIC1 ZIC2	6.83e-05	8	55	2	30094508
Pubmed	Localization of Tfap2β, Casq2, Penk, Zic1, and Zic3 Expression in the Developing Retina, Muscle, and Sclera of the Embryonic Mouse Eye.	ZIC1 ZIC3	6.83e-05	8	55	2	31638440
Pubmed	The role of Zic genes in inner ear development in the mouse: Exploring mutant mouse phenotypes.	ZIC1 ZIC2	8.78e-05	9	55	2	25178196
Pubmed	Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia.	SP9 REST ZIC1	1.03e-04	57	55	3	35377797
Pubmed	Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease.	HIF1A CYP2B6	1.10e-04	10	55	2	19651758
Pubmed	FGF8 signaling patterns the telencephalic midline by regulating putative key factors of midline development.	ZIC1 ZIC2	1.34e-04	11	55	2	18547559
Pubmed	Septal contributions to olfactory bulb interneuron diversity in the embryonic mouse telencephalon: role of the homeobox gene Gsx2.	SP8 ZIC3	1.34e-04	11	55	2	28814342
Pubmed	Role of Pax6 in development of the cerebellar system.	ZIC1 ZIC2	1.34e-04	11	55	2	10409504
Pubmed	Zic2 controls cerebellar development in cooperation with Zic1.	ZIC1 ZIC2	1.34e-04	11	55	2	11756505
Pubmed	Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects.	HIF1A REST	1.60e-04	12	55	2	21072209
Pubmed	Transcription Factors Sp8 and Sp9 Regulate Medial Ganglionic Eminence-Derived Cortical Interneuron Migration.	SP8 SP9	1.89e-04	13	55	2	31001083
Pubmed	Transcription factors Sp8 and Sp9 regulate the development of caudal ganglionic eminence-derived cortical interneurons.	SP8 SP9	1.89e-04	13	55	2	31070778
Pubmed	Homeobox Gene Six3 is Required for the Differentiation of D2-Type Medium Spiny Neurons.	SP8 SP9	1.89e-04	13	55	2	34014554
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF486 ZNF98 ZNF441 ZNF587B	1.97e-04	181	55	4	37372979
Pubmed	Deletion of CHD8 in cerebellar granule neuron progenitors leads to severe cerebellar hypoplasia, ataxia, and psychiatric behavior in mice.	ZIC1 ZIC2	2.21e-04	14	55	2	35231638
Pubmed	The onion skin-like organization of the septum arises from multiple embryonic origins to form multiple adult neuronal fates.	SP8 ZIC1	2.21e-04	14	55	2	22820053
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PTPRE WDR20 CEP290 CCDC138 RCN1 PSMC4 KIF14 PTPN21	2.31e-04	1049	55	8	27880917
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	SP4 HIF1A ZNF716 ZNF318 REST ZBTB24 ZNF710	2.74e-04	808	55	7	20412781
Pubmed	New semidominant mutations that affect mouse development.	ZIC2 ZIC3	2.90e-04	16	55	2	15384171
Pubmed	Sp6 and Sp8 transcription factors control AER formation and dorsal-ventral patterning in limb development.	SP8 SP6	2.90e-04	16	55	2	25166858
Pubmed	The Genetic Basis of Baculum Size and Shape Variation in Mice.	HIF1A KIF14	2.90e-04	16	55	2	26935419
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	SUPT20H PSMC4 KIF14 ZNF318 ZNF714 OBI1	3.27e-04	588	55	6	38580884
Pubmed	Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping.	ZNF407 ALPK2	3.29e-04	17	55	2	19690890
Pubmed	The transcription factor Zfp503 promotes the D1 MSN identity and represses the D2 MSN identity.	SP8 SP9	3.29e-04	17	55	2	36081908
Pubmed	In vivo dual-tagging proteomic approach in studying signaling pathways in immune response.	OBI1 LRRFIP2	3.29e-04	17	55	2	15952741
Pubmed	Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation.	SP8 SP9	3.29e-04	17	55	2	17376983
Pubmed	Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice.	ZIC1 ZIC2	3.29e-04	17	55	2	22578469
Pubmed	Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain.	ZIC1 ZIC3	3.29e-04	17	55	2	26025376
Pubmed	Ipsilateral and Contralateral Retinal Ganglion Cells Express Distinct Genes during Decussation at the Optic Chiasm.	ZIC1 ZIC2	3.70e-04	18	55	2	27957530
Pubmed	Analyses with double knockouts of the Bmpr1a and Bmpr1b genes demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip.	ZIC1 ZIC2	3.70e-04	18	55	2	31869353
Pubmed	Role of Epiprofin, a zinc-finger transcription factor, in limb development.	SP8 SP6	4.13e-04	19	55	2	19913006
Pubmed	Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development.	SP8 SP9	4.13e-04	19	55	2	28981617
Pubmed	Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog.	SP8 SP9	4.13e-04	19	55	2	32234482
Pubmed	Delineating a conserved genetic cassette promoting outgrowth of body appendages.	SP8 SP6	4.58e-04	20	55	2	23358455
Pubmed	Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development.	ZIC1 ZIC3	6.08e-04	23	55	2	16893423
Pubmed	Sp9 Regulates Medial Ganglionic Eminence-Derived Cortical Interneuron Development.	SP8 SP9	6.63e-04	24	55	2	29878134
Pubmed	Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord.	ZIC1 ZIC2	7.20e-04	25	55	2	15229182
Pubmed	Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants.	SP8 SP9	7.20e-04	25	55	2	23042297
Pubmed	Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells.	ZIC2 ZIC3	7.79e-04	26	55	2	22992956
Pubmed	A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling.	ZIC1 ZIC2	7.79e-04	26	55	2	19850029
Pubmed	Integrative genomic analysis of early neurogenesis reveals a temporal genetic program for differentiation and specification of preplate and Cajal-Retzius neurons.	ZIC1 ZIC2	8.40e-04	27	55	2	33760820
Pubmed	Global gene expression analysis of murine limb development.	SP4 SP6 E4F1	8.57e-04	117	55	3	22174793
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	HIF1A SP6 ZNF318 E4F1 REST ZFY	8.72e-04	709	55	6	22988430
Pubmed	Dlx1/2 are Central and Essential Components in the Transcriptional Code for Generating Olfactory Bulb Interneurons.	SP8 SP9	9.04e-04	28	55	2	30796806
Pubmed	SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression.	SP8 SP9	9.04e-04	28	55	2	29967281
Pubmed	Genetic interplay between the transcription factors Sp8 and Emx2 in the patterning of the forebrain.	SP8 SP9	1.04e-03	30	55	2	17470284
Pubmed	The DNA sequence and biology of human chromosome 19.	CYP2B6 PSMC4 ZNF814 ZNF98	1.07e-03	284	55	4	15057824
Pubmed	Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.	SP8 SP9 ZIC1	1.16e-03	130	55	3	19386638
Pubmed	Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum.	SP8 SP9	1.18e-03	32	55	2	35156680
Pubmed	Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways.	SP8 SP9 ZIC1	1.27e-03	134	55	3	19030180
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	CCNT2 SUPT20H RCN1 OBI1 ZFY	1.54e-03	533	55	5	30554943
Cytoband	19p12	ZNF492 ZNF486 ZNF98 ZNF714	4.36e-06	90	55	4	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF492 ZNF486 ZNF98 ZNF714	1.46e-05	122	55	4	chr19p12
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	SP8 SP4 ZNF492 ZNF716 ZNF486 SP6 ZNF816 ZNF814 SP9 ZNF407 ZNF488 ZNF318 E4F1 ZNF700 ZNF98 ZNF714 ZBTB24 ZNF441 ZNF587B ZFY ZIC1 ZNF710 ZIC2 ZIC3	6.39e-23	718	43	24	28
GeneFamily	Zinc fingers C2H2-type\|Sp transcription factors	SP8 SP4 SP6 SP9	3.46e-09	9	43	4	755
ToppCell	Thalamus\|World / BrainAtlas - Mouse McCarroll V32	UNC13C ALPK2 ZIC1 ZIC2 ZIC3	3.28e-07	116	55	5	5ddfb2dd5459ff6d7ae38163a38eae64fda283b7
ToppCell	21-Trachea-Epithelial-Epithelial\|Trachea / Age, Tissue, Lineage and Cell class	CDO1 SP9 ALPK2 ZIC1 ZIC2	4.03e-06	193	55	5	9a8bb44a37f3202e3123a6680bd5545dc91a6d40
Drug	vinylene	SP8 SP4 ZNF492 SP6 REST ZNF98 ZBTB24 ZFY ZIC1 ZIC3	3.31e-10	245	55	10	CID000006326
Disease	Meckel syndrome type 1	CEP290 KIF14	4.58e-04	18	52	2	C3714506
Disease	visceral heterotaxy (implicated_via_orthology)	CEP290 ZIC3	1.95e-03	37	52	2	DOID:0050545 (implicated_via_orthology)
Disease	gait measurement	CCNT2 KIF14 POM121L2	2.37e-03	150	52	3	EFO_0007680

Protein segments in the cluster

Peptide	Gene	Start	Entry
ASHNHHSKMSKSSKS	CCNT2	626	O60583
HMEKEKSNAHSEFSH	CYP2B6	271	P20813
CHKTVHSMASKFTDG	ALPK2	231	Q86TB3
MSVIFHSDKHVASHG	CDCP2	121	Q5VXM1
TKDSHHTLLHQEGMS	DMXL2	571	Q8TDJ6
FHSLGKMSHVDLSHN	CD180	516	Q99467
HDSSDHHTFKKMLPR	RCN1	156	Q15293
KTHLTRHMRTHSGEK	REST	316	Q13127
MAHVLQKPKHSGTHS	C20orf96	1	Q9NUD7
IKNLHSSHSSGLMDK	KIF14	1211	Q15058
SLEKHLQTMHGTTTH	PTPRE	406	P23469
HLTKTHHDMFTKGQV	HIF1A	286	Q16665
TMGCLATTHSKAIHK	ABAT	221	P80404
TLAAMHHFAKHKSPL	OR51A7	256	Q8NH64
AAKSMLDPAHKSHFH	EBLN2	106	Q6P2I7
SLFKMSSEMHSLHNH	OBI1	671	Q5W0B1
HSYSHSHGMKKRSSD	LRRFIP2	126	Q9Y608
GHKKSLSDATMLIHS	PTPN21	696	Q16825
SDHHLSKVKHEESGM	CCDC138	366	Q96M89
KAHLGHQLSMHYESK	CEP290	2181	O15078
TGHKNKVTMTFHSKF	CDO1	171	Q16878
HHNSIDIKRMKHFGS	CASC2	46	Q6XLA1
FKTGSILKAHMVTHS	E4F1	201	Q66K89
FMRSDHLSKHVKTHQ	SP4	716	Q02446
GKTMLAKAVAHHTTA	PSMC4	211	P43686
KDHKRNHSMGHISSK	WDR20	476	Q8TBZ3
NHSMGHISSKSSDKL	WDR20	481	Q8TBZ3
SDHLAKHMKTHEGAK	SP6	326	Q3SY56
HHFHGLVKATSVVMS	POM121L2	611	Q96KW2
FMRSDHLSKHIKTHN	SP9	401	P0CG40
MRSDHLSKHVKTHSG	SP8	426	Q8IXZ3
SMEKSHHFEDSKTLH	CCDC110	126	Q8TBZ0
NSSDRKKHMHVHTSD	ZIC3	371	O60481
FSSLHIHARTHMGEK	ZNF700	716	Q9H0M5
LTSDLVFHMRSHHKK	ZNF488	286	Q96MN9
GKAFKHSSTLTTHKM	ZNF714	206	Q96N38
GKAFNVSSHLTTHKM	ZNF714	346	Q96N38
VSSHLTTHKMIHTGE	ZNF714	351	Q96N38
SAFHKHERTHSMEKP	ZNF441	656	Q8N8Z8
ASHGKDMVHKELHRF	YIF1A	71	O95070
HDYIKHLGHMGSKAS	UNC13C	306	Q8NB66
HHHRHTGSQSKSKMK	SUPT20H	756	Q8NEM7
CHKAFTQTSHLKRHM	ZNF710	356	Q8N1W2
HSSLANHKNMHTGEK	ZNF716	476	A6NP11
SVHKNHRYKMHTSTG	UBR1	131	Q8IWV7
TKHSLLEHMSLHSGQ	ZBTB24	361	O43167
HGDSMKHFSTKHILS	ZNF587B	216	E7ETH6
SSHLTTHKMIHTGEK	ZNF492	461	Q9P255
SSDRKKHMHVHTSDK	ZIC1	346	Q15915
QSSHLTTHKMIHTGE	ZNF98	501	A6NK75
SHKAESSSALHMHIK	ZNF407	221	Q9C0G0
HTNSHVKMSGAAKHK	SETBP1	1096	Q9Y6X0
GKAFTRSSHLTMHKI	ZNF486	356	Q96H40
FFTHMHNKKHTQTLD	ZNF318	1081	Q5VUA4
CGESMKHFSTKHILS	ZNF814	216	B7Z6K7
HSHLPELHMFQTKGK	ZNF816	161	Q0VGE8
NSSDRKKHMHVHTSD	ZIC2	376	O95409
KHFSHAGALFTHKMV	ZFY	491	P08048