Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5D KDM5C	4.72e-05	6	36	2	GO:0034647
GeneOntologyMolecularFunction	histone H3K4 demethylase activity	KDM5D KDM5C	8.79e-05	8	36	2	GO:0032453
GeneOntologyMolecularFunction	phosphatidylethanolamine binding	MAP1LC3B MAP1LC3B2	5.30e-04	19	36	2	GO:0008429
GeneOntologyMolecularFunction	ceramide binding	MAP1LC3B MAP1LC3B2	5.88e-04	20	36	2	GO:0097001
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM5D KDM5C	1.16e-03	28	36	2	GO:0141052
GeneOntologyMolecularFunction	histone demethylase activity	KDM5D KDM5C	1.42e-03	31	36	2	GO:0032452
GeneOntologyMolecularFunction	protein demethylase activity	KDM5D KDM5C	1.52e-03	32	36	2	GO:0140457
GeneOntologyMolecularFunction	sphingolipid binding	MAP1LC3B MAP1LC3B2	1.71e-03	34	36	2	GO:0046625
GeneOntologyMolecularFunction	dynein intermediate chain binding	SPTBN5 DYNC1H1	2.02e-03	37	36	2	GO:0045505
GeneOntologyMolecularFunction	demethylase activity	KDM5D KDM5C	2.85e-03	44	36	2	GO:0032451
GeneOntologyMolecularFunction	miRNA binding	PUM2 PUM1	3.38e-03	48	36	2	GO:0035198
GeneOntologyMolecularFunction	regulatory RNA binding	PUM2 PUM1	5.58e-03	62	36	2	GO:0061980
GeneOntologyMolecularFunction	2-oxoglutarate-dependent dioxygenase activity	KDM5D KDM5C	6.12e-03	65	36	2	GO:0016706
GeneOntologyBiologicalProcess	positive regulation of RIG-I signaling pathway	PUM2 PUM1	1.61e-04	11	36	2	GO:1900246
GeneOntologyBiologicalProcess	cellular response to nitrogen levels	MAP1LC3B MAP1LC3B2	1.93e-04	12	36	2	GO:0043562
GeneOntologyBiologicalProcess	positive regulation of miRNA-mediated gene silencing	PUM2 PUM1	1.93e-04	12	36	2	GO:2000637
GeneOntologyBiologicalProcess	cellular response to nitrogen starvation	MAP1LC3B MAP1LC3B2	1.93e-04	12	36	2	GO:0006995
GeneOntologyBiologicalProcess	positive regulation of post-transcriptional gene silencing by RNA	PUM2 PUM1	2.28e-04	13	36	2	GO:1900370
GeneOntologyBiologicalProcess	positive regulation of post-transcriptional gene silencing	PUM2 PUM1	2.28e-04	13	36	2	GO:0060148
GeneOntologyBiologicalProcess	positive regulation of mucus secretion	MAP1LC3B MAP1LC3B2	2.28e-04	13	36	2	GO:0070257
GeneOntologyBiologicalProcess	regulation of mucus secretion	MAP1LC3B MAP1LC3B2	3.50e-04	16	36	2	GO:0070255
GeneOntologyCellularComponent	cytoplasmic region	SPTBN5 RPGRIP1 MARK2 MAP1LC3B MAP1LC3B2 DYNC1H1	3.71e-05	360	37	6	GO:0099568
GeneOntologyCellularComponent	autophagosome membrane	MAP1LC3B MAP1LC3B2 ENTPD4	1.40e-04	57	37	3	GO:0000421
GeneOntologyCellularComponent	microtubule associated complex	SPTBN5 MAP1LC3B MAP1LC3B2 DYNC1H1	1.84e-04	161	37	4	GO:0005875
GeneOntologyCellularComponent	plasma membrane bounded cell projection cytoplasm	SPTBN5 RPGRIP1 MAP1LC3B MAP1LC3B2 DYNC1H1	2.27e-04	317	37	5	GO:0032838
GeneOntologyCellularComponent	autolysosome	MAP1LC3B MAP1LC3B2	4.58e-04	18	37	2	GO:0044754
GeneOntologyCellularComponent	cell cortex	SPTBN5 EXOC1 CTTNBP2 MARK2 DYNC1H1	4.68e-04	371	37	5	GO:0005938
GeneOntologyCellularComponent	axoneme	SPTBN5 RPGRIP1 MAP1LC3B MAP1LC3B2	4.78e-04	207	37	4	GO:0005930
GeneOntologyCellularComponent	ciliary plasm	SPTBN5 RPGRIP1 MAP1LC3B MAP1LC3B2	4.86e-04	208	37	4	GO:0097014
GeneOntologyCellularComponent	postsynaptic actin cytoskeleton	CTTNBP2 FAM107A	5.11e-04	19	37	2	GO:0098871
GeneOntologyCellularComponent	postsynaptic cytoskeleton	CTTNBP2 FAM107A	9.65e-04	26	37	2	GO:0099571
GeneOntologyCellularComponent	secondary lysosome	MAP1LC3B MAP1LC3B2	9.65e-04	26	37	2	GO:0005767
GeneOntologyCellularComponent	autophagosome	MAP1LC3B MAP1LC3B2 ENTPD4	1.21e-03	119	37	3	GO:0005776
GeneOntologyCellularComponent	cell cortex region	SPTBN5 MARK2	2.88e-03	45	37	2	GO:0099738
GeneOntologyCellularComponent	glutamatergic synapse	DLGAP1 CTTNBP2 MARK2 FAM107A FAAH NRP2	2.89e-03	817	37	6	GO:0098978
GeneOntologyCellularComponent	photoreceptor connecting cilium	SPTBN5 RPGRIP1	3.27e-03	48	37	2	GO:0032391
Domain	Pumilio_RNA-bd	PUM2 PUM1	3.82e-06	2	37	2	IPR033712
Domain	PUM-HD	PUM2 PUM1	1.14e-05	3	37	2	IPR033133
Domain	PUF	PUM2 PUM1	1.14e-05	3	37	2	PF00806
Domain	PUM_HD	PUM2 PUM1	1.14e-05	3	37	2	PS50303
Domain	Pumilio_RNA-bd_rpt	PUM2 PUM1	2.29e-05	4	37	2	IPR001313
Domain	Lys_sp_deMease-like_dom	KDM5D KDM5C	2.29e-05	4	37	2	IPR013637
Domain	PLU-1	KDM5D KDM5C	2.29e-05	4	37	2	PF08429
Domain	PUM	PUM2 PUM1	2.29e-05	4	37	2	PS50302
Domain	Pumilio	PUM2 PUM1	2.29e-05	4	37	2	SM00025
Domain	zf-C5HC2	KDM5D KDM5C	3.80e-05	5	37	2	PF02928
Domain	Znf_C5HC2	KDM5D KDM5C	3.80e-05	5	37	2	IPR004198
Domain	Atg8-like	MAP1LC3B MAP1LC3B2	1.06e-04	8	37	2	IPR004241
Domain	Atg8	MAP1LC3B MAP1LC3B2	1.06e-04	8	37	2	PF02991
Domain	JmjN	KDM5D KDM5C	1.70e-04	10	37	2	PF02375
Domain	JmjN	KDM5D KDM5C	1.70e-04	10	37	2	SM00545
Domain	JMJN	KDM5D KDM5C	1.70e-04	10	37	2	PS51183
Domain	JmjN	KDM5D KDM5C	1.70e-04	10	37	2	IPR003349
Domain	-	KDM5D KDM5C	3.95e-04	15	37	2	1.10.150.60
Domain	ARID	KDM5D KDM5C	3.95e-04	15	37	2	PF01388
Domain	BRIGHT	KDM5D KDM5C	3.95e-04	15	37	2	SM00501
Domain	ARID_dom	KDM5D KDM5C	3.95e-04	15	37	2	IPR001606
Domain	ARID	KDM5D KDM5C	3.95e-04	15	37	2	PS51011
Domain	JmjC	KDM5D KDM5C	1.03e-03	24	37	2	PF02373
Domain	JMJC	KDM5D KDM5C	1.82e-03	32	37	2	PS51184
Domain	JmjC_dom	KDM5D KDM5C	1.82e-03	32	37	2	IPR003347
Domain	JmjC	KDM5D KDM5C	1.94e-03	33	37	2	SM00558
Domain	Zinc_finger_PHD-type_CS	KDM5D KDM5C	7.34e-03	65	37	2	IPR019786
Domain	PHD	KDM5D KDM5C	9.68e-03	75	37	2	PF00628
Pathway	KEGG_MEDICUS_REFERENCE_AUTOPHAGOSOME_AND_LYSOSOME_FUSION_TETHERING_FACTOR_GRASP55	MAP1LC3B MAP1LC3B2	6.53e-05	6	30	2	M47979
Pathway	KEGG_MEDICUS_REFERENCE_TBK1_MEDIATED_AUTOPHAGOSOME_FORMATION	MAP1LC3B MAP1LC3B2	1.95e-04	10	30	2	M47745
Pathway	REACTOME_PEXOPHAGY	MAP1LC3B MAP1LC3B2	2.38e-04	11	30	2	MM15673
Pathway	REACTOME_RECEPTOR_MEDIATED_MITOPHAGY	MAP1LC3B MAP1LC3B2	2.85e-04	12	30	2	MM15525
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_P62_TO_PINK_PARKIN_MEDIATED_AUTOPHAGOSOME_FORMATION	MAP1LC3B MAP1LC3B2	3.37e-04	13	30	2	M47744
Pathway	KEGG_MEDICUS_REFERENCE_AUTOPHAGY_VESICLE_NUCLEATION_ELONGATION_MATURATION_LC3_II_FORMATION	MAP1LC3B MAP1LC3B2	3.37e-04	13	30	2	M47458
Pathway	KEGG_MEDICUS_REFERENCE_AUTOPHAGY_VESICLE_NUCLEATION_ELONGATION_MATURATION_SEQUESTOSOME_1_LIKE_RECEPTOR	MAP1LC3B MAP1LC3B2	3.92e-04	14	30	2	M47975
Pathway	REACTOME_SELECTIVE_AUTOPHAGY	MAP1LC3B MAP1LC3B2 DYNC1H1	4.89e-04	73	30	3	MM15672
Pathway	KEGG_MEDICUS_REFERENCE_AUTOPHAGOSOME_AND_LYSOSOME_FUSION_TETHERING_FACTOR	MAP1LC3B MAP1LC3B2	5.16e-04	16	30	2	M47978
Pathway	KEGG_MEDICUS_REFERENCE_PINK_PARKIN_MEDIATED_AUTOPHAGOSOME_FORMATION	MAP1LC3B MAP1LC3B2	5.84e-04	17	30	2	M47742
Pubmed	UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy.	MAP1LC3B MAP1LC3B2 AFP	6.18e-08	8	37	3	23431188
Pubmed	Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.	KDM5D KDM5C	1.10e-06	2	37	2	32081420
Pubmed	Nutrient starvation affects expression of LC3 family at the feto-maternal interface during murine placentation.	MAP1LC3B MAP1LC3B2	1.10e-06	2	37	2	25421500
Pubmed	A Quantitative and Predictive Model for RNA Binding by Human Pumilio Proteins.	PUM2 PUM1	1.10e-06	2	37	2	31078383
Pubmed	Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells.	MAP1LC3B MAP1LC3B2	1.10e-06	2	37	2	28928467
Pubmed	Andrographolide alleviates imiquimod-induced psoriasis in mice via inducing autophagic proteolysis of MyD88.	MAP1LC3B MAP1LC3B2	1.10e-06	2	37	2	27265145
Pubmed	Principles of mRNA control by human PUM proteins elucidated from multimodal experiments and integrative data analysis.	PUM2 PUM1	1.10e-06	2	37	2	32753408
Pubmed	Transcriptomic Changes Predict Metabolic Alterations in LC3 Associated Phagocytosis in Aged Mice.	MAP1LC3B MAP1LC3B2	1.10e-06	2	37	2	37047689
Pubmed	Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.	KDM5D KDM5C	1.10e-06	2	37	2	9060413
Pubmed	Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins.	PUM2 PUM1	1.10e-06	2	37	2	12459267
Pubmed	PUMILIO proteins promote colorectal cancer growth via suppressing p21.	PUM2 PUM1	1.10e-06	2	37	2	35338151
Pubmed	Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins.	PUM2 PUM1	1.10e-06	2	37	2	29165587
Pubmed	Effects of PUMILIO1 and PUMILIO2 knockdown on cardiomyogenic differentiation of human embryonic stem cells culture.	PUM2 PUM1	1.10e-06	2	37	2	32437472
Pubmed	Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.	KDM5D KDM5C	1.10e-06	2	37	2	10441747
Pubmed	Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension.	MAP1LC3B MAP1LC3B2	1.10e-06	2	37	2	20889906
Pubmed	Cell-Penetrating Nanoparticles Activate the Inflammasome to Enhance Antibody Production by Targeting Microtubule-Associated Protein 1-Light Chain 3 for Degradation.	MAP1LC3B MAP1LC3B2	1.10e-06	2	37	2	32057231
Pubmed	PUMILIO-mediated translational control of somatic cell cycle program promotes folliculogenesis and contributes to ovarian cancer progression.	PUM2 PUM1	1.10e-06	2	37	2	35507203
Pubmed	Bespoke RNA recognition by Pumilios.	PUM2 PUM1	1.10e-06	2	37	2	26517885
Pubmed	Microtubule-Associated Protein 1 Light Chain 3B, (LC3B) Is Necessary to Maintain Lipid-Mediated Homeostasis in the Retinal Pigment Epithelium.	MAP1LC3B MAP1LC3B2	1.10e-06	2	37	2	30349463
Pubmed	Susceptibility of microtubule-associated protein 1 light chain 3β (MAP1LC3B/LC3B) knockout mice to lung injury and fibrosis.	MAP1LC3B MAP1LC3B2	1.10e-06	2	37	2	31431059
Pubmed	Mouse Pum1 and Pum2 genes, members of the Pumilio family of RNA-binding proteins, show differential expression in fetal and adult hematopoietic stem cells and progenitors.	PUM2 PUM1	1.10e-06	2	37	2	12667987
Pubmed	Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.	KDM5D KDM5C	1.10e-06	2	37	2	16416087
Pubmed	Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer.	PUM2 PUM1	1.10e-06	2	37	2	12771951
Pubmed	Alternate modes of cognate RNA recognition by human PUMILIO proteins.	PUM2 PUM1	1.10e-06	2	37	2	21397187
Pubmed	Individual Atg8 paralogs and a bacterial metabolite sequentially promote hierarchical CASM-xenophagy induction and transition.	MAP1LC3B MAP1LC3B2	1.10e-06	2	37	2	38656870
Pubmed	Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system.	PUM2 PUM1	1.10e-06	2	37	2	18776931
Pubmed	Microtubule-associated protein 1B is involved in the initial stages of axonogenesis in peripheral nervous system cultured neurons.	MAP1LC3B MAP1LC3B2	1.10e-06	2	37	2	12088839
Pubmed	Lc3 over-expression improves survival and attenuates lung injury through increasing autophagosomal clearance in septic mice.	MAP1LC3B MAP1LC3B2	1.10e-06	2	37	2	22968077
Pubmed	Peroxisome turnover and diurnal modulation of antioxidant activity in retinal pigment epithelia utilizes microtubule-associated protein 1 light chain 3B (LC3B).	MAP1LC3B MAP1LC3B2	1.10e-06	2	37	2	31577510
Pubmed	Characterization of RNP Networks of PUM1 and PUM2 Post-Transcriptional Regulators in TCam-2 Cells, a Human Male Germ Cell Model.	PUM2 PUM1	1.10e-06	2	37	2	32316190
Pubmed	[Preparation of an autophagy-targeted antituberculosis DNA vaccine encoding LpqH fused with LC3].	MAP1LC3B MAP1LC3B2	1.10e-06	2	37	2	24909277
Pubmed	A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.	KDM5D KDM5C	1.10e-06	2	37	2	7524912
Pubmed	LC3 conjugation system in mammalian autophagy.	MAP1LC3B MAP1LC3B2	1.10e-06	2	37	2	15325588
Pubmed	LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy.	MAP1LC3B MAP1LC3B2	1.10e-06	2	37	2	37315562
Pubmed	Autophagy plays an essential role in cigarette smoke-induced expression of MUC5AC in airway epithelium.	MAP1LC3B MAP1LC3B2	3.30e-06	3	37	2	27036871
Pubmed	The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals the importance of the flanking region of the LIR motif.	MAP1LC3B MAP1LC3B2	3.30e-06	3	37	2	28291748
Pubmed	Microtubule-Associated Protein 1 Light Chain 3 (LC3) Isoforms in RPE and Retina.	MAP1LC3B MAP1LC3B2	3.30e-06	3	37	2	29721994
Pubmed	HIV protease inhibitor-induced cardiac dysfunction and fibrosis is mediated by platelet-derived TGF-β1 and can be suppressed by exogenous carbon monoxide.	MAP1LC3B MAP1LC3B2	3.30e-06	3	37	2	29088262
Pubmed	Antagonistic and cooperative AGO2-PUM interactions in regulating mRNAs.	PUM2 PUM1	3.30e-06	3	37	2	30333515
Pubmed	Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome.	PUM2 PUM1	3.30e-06	3	37	2	33397688
Pubmed	Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes.	MAP1LC3B MAP1LC3B2	3.30e-06	3	37	2	24095928
Pubmed	NORAD: Defender of the Genome.	PUM2 PUM1	3.30e-06	3	37	2	27157388
Pubmed	COP9 signalosome component CSN-5 stabilizes PUF proteins FBF-1 and FBF-2 in Caenorhabditis elegans germline stem and progenitor cells.	PUM2 PUM1	3.30e-06	3	37	2	38427913
Pubmed	Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction.	MAP1LC3B MAP1LC3B2	3.30e-06	3	37	2	27636016
Pubmed	Classical autophagy proteins LC3B and ATG4B facilitate melanosome movement on cytoskeletal tracks.	MAP1LC3B MAP1LC3B2	3.30e-06	3	37	2	28598240
Pubmed	Identification of a mouse male-specific transplantation antigen, H-Y.	KDM5D KDM5C	3.30e-06	3	37	2	7544442
Pubmed	A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection.	PUM2 PUM1	3.30e-06	3	37	2	25340845
Pubmed	Autophagy proteins are modulated in the liver and hypothalamus of the offspring of mice with diet-induced obesity.	MAP1LC3B MAP1LC3B2	3.30e-06	3	37	2	27180121
Pubmed	ATG7 is dispensable for LC3-PE conjugation in thioglycolate-elicited mouse peritoneal macrophages.	MAP1LC3B MAP1LC3B2	3.30e-06	3	37	2	33459130
Pubmed	BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver.	MAP1LC3B MAP1LC3B2	3.30e-06	3	37	2	33459136
Pubmed	PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells.	PUM2 PUM1	3.30e-06	3	37	2	28232582
Pubmed	Autophagy is required and protects against apoptosis during myoblast differentiation.	MAP1LC3B MAP1LC3B2	3.30e-06	3	37	2	24865278
Pubmed	Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins.	PUM2 PUM1	3.30e-06	3	37	2	26724866
Pubmed	Developmental expression of LC3alpha and beta: absence of fibronectin or autophagy phenotype in LC3beta knockout mice.	MAP1LC3B MAP1LC3B2	3.30e-06	3	37	2	18069693
Pubmed	BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy.	MAP1LC3B MAP1LC3B2	3.30e-06	3	37	2	24591579
Pubmed	Pumilio facilitates miRNA regulation of the E2F3 oncogene.	PUM2 PUM1	3.30e-06	3	37	2	22345517
Pubmed	Cdx2 regulates endo-lysosomal function and epithelial cell polarity.	MARK2 MAP1LC3B MAP1LC3B2	5.92e-06	33	37	3	20551175
Pubmed	Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.	MAP1LC3B MAP1LC3B2 DYNC1H1	6.48e-06	34	37	3	25915474
Pubmed	p62 aggregates mediated Caspase 8 activation is responsible for progression of ovarian cancer.	MAP1LC3B MAP1LC3B2	6.60e-06	4	37	2	30941888
Pubmed	Hyperoxia-induced LC3B interacts with the Fas apoptotic pathway in epithelial cell death.	MAP1LC3B MAP1LC3B2	6.60e-06	4	37	2	22095627
Pubmed	Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide.	MAP1LC3B MAP1LC3B2	6.60e-06	4	37	2	32372061
Pubmed	Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation.	MAP1LC3B MAP1LC3B2	6.60e-06	4	37	2	32376415
Pubmed	Mammalian Pum1 and Pum2 Control Body Size via Translational Regulation of the Cell Cycle Inhibitor Cdkn1b.	PUM2 PUM1	6.60e-06	4	37	2	30811992
Pubmed	Deficiency of autophagy protein Map1-LC3b mediates IL-17-dependent lung pathology during respiratory viral infection via ER stress-associated IL-1.	MAP1LC3B MAP1LC3B2	6.60e-06	4	37	2	25669150
Pubmed	Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.	KDM5D KDM5C	6.60e-06	4	37	2	16541399
Pubmed	Autophagy mediates tolerance to Staphylococcus aureus alpha-toxin.	MAP1LC3B MAP1LC3B2	6.60e-06	4	37	2	25816775
Pubmed	Aging is associated with hypermethylation of autophagy genes in macrophages.	MAP1LC3B MAP1LC3B2	6.60e-06	4	37	2	26909551
Pubmed	STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain.	MAP1LC3B MAP1LC3B2	6.60e-06	4	37	2	33201170
Pubmed	Modulation of autophagy influences development and apoptosis in mouse embryos developing in vitro.	MAP1LC3B MAP1LC3B2	6.60e-06	4	37	2	21681844
Pubmed	The Hedgehog signalling pathway regulates autophagy.	MAP1LC3B MAP1LC3B2	6.60e-06	4	37	2	23149744
Pubmed	MAP1LC3B overexpression protects against Hermansky-Pudlak syndrome type-1-induced defective autophagy in vitro.	MAP1LC3B MAP1LC3B2	6.60e-06	4	37	2	26719147
Pubmed	Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction.	MAP1LC3B MAP1LC3B2	6.60e-06	4	37	2	24200693
Pubmed	The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice.	MAP1LC3B MAP1LC3B2	6.60e-06	4	37	2	18768753
Pubmed	Hepatocellular carcinoma-related cyclin D1 is selectively regulated by autophagy degradation system.	MAP1LC3B MAP1LC3B2	6.60e-06	4	37	2	29328502
Pubmed	X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.	KDM5D KDM5C	6.60e-06	4	37	2	32732223
Pubmed	A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.	KDM5D KDM5C	6.60e-06	4	37	2	7951230
Pubmed	Perturbation of PI3K/Akt signaling affected autophagy modulation in dystrophin-deficient myoblasts.	MAP1LC3B MAP1LC3B2	6.60e-06	4	37	2	34706731
Pubmed	Acetylation modulates LC3 stability and cargo recognition.	MAP1LC3B MAP1LC3B2	6.60e-06	4	37	2	30633346
Pubmed	Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway.	MAP1LC3B MAP1LC3B2	6.60e-06	4	37	2	22055190
Pubmed	Autophagic compartments gain access to the MHC class II compartments in thymic epithelium.	MAP1LC3B MAP1LC3B2	6.60e-06	4	37	2	19915056
Pubmed	Target RNA motif and target mRNAs of the Quaking STAR protein.	PUM2 PUM1	6.60e-06	4	37	2	16041388
Pubmed	The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.	KDM5D KDM5C	6.60e-06	4	37	2	17320160
Pubmed	The Contribution of Melanoregulin to Microtubule-Associated Protein 1 Light Chain 3 (LC3) Associated Phagocytosis in Retinal Pigment Epithelium.	MAP1LC3B MAP1LC3B2	6.60e-06	4	37	2	25301234
Pubmed	Autophagy exacerbates electrical remodeling in atrial fibrillation by ubiquitin-dependent degradation of L-type calcium channel.	MAP1LC3B MAP1LC3B2	6.60e-06	4	37	2	30158642
Pubmed	Autophagy prior to chondrocyte cell death during the degeneration of Meckel's cartilage.	MAP1LC3B MAP1LC3B2	1.10e-05	5	37	2	22371349
Pubmed	PUM1 and PUM2 exhibit different modes of regulation for SIAH1 that involve cooperativity with NANOS paralogues.	PUM2 PUM1	1.10e-05	5	37	2	30269240
Pubmed	CaV2.2 channel cell surface expression is regulated by the light chain 1 (LC1) of the microtubule-associated protein B (MAP1B) via UBE2L3-mediated ubiquitination and degradation.	MAP1LC3B MAP1LC3B2	1.10e-05	5	37	2	24566975
Pubmed	An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline.	PUM2 PUM1	1.10e-05	5	37	2	27170441
Pubmed	In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11.	MAP1LC3B MAP1LC3B2	1.10e-05	5	37	2	26284655
Pubmed	Autophagy proteins are required for club cell structure and function in airways.	MAP1LC3B MAP1LC3B2	1.10e-05	5	37	2	31116580
Pubmed	Autophagy-related gene Atg5 is essential for astrocyte differentiation in the developing mouse cortex.	MAP1LC3B MAP1LC3B2	1.10e-05	5	37	2	25227738
Pubmed	Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells.	MAP1LC3B MAP1LC3B2	1.10e-05	5	37	2	28916785
Pubmed	Cytosolic clearance of replication-deficient mutants reveals Francisella tularensis interactions with the autophagic pathway.	MAP1LC3B MAP1LC3B2	1.10e-05	5	37	2	22863802
Pubmed	Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.	MAP1LC3B MAP1LC3B2	1.10e-05	5	37	2	21151103
Pubmed	Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1.	MAP1LC3B MAP1LC3B2	1.10e-05	5	37	2	29937374
Pubmed	Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3.	MAP1LC3B MAP1LC3B2	1.65e-05	6	37	2	24747438
Pubmed	The RNA-binding protein Musashi-1 is produced in the developing and adult mouse eye.	PUM2 PUM1	1.65e-05	6	37	2	17768378
Pubmed	Autophagy appears during the development of the mouse lower first molar.	MAP1LC3B MAP1LC3B2	1.65e-05	6	37	2	23052835
Pubmed	Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling.	MAP1LC3B MAP1LC3B2	1.65e-05	6	37	2	22138575
Pubmed	Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis.	MAP1LC3B MAP1LC3B2	1.65e-05	6	37	2	34524943
Interaction	GUSBP5 interactions	PUM2 NCOR1 PUM1 KDM5C	1.06e-05	75	37	4	int:GUSBP5
GeneFamily	AT-rich interaction domain containing	KDM5D KDM5C	1.47e-04	15	22	2	418
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5D KDM5C	3.84e-04	24	22	2	485
GeneFamily	Autophagy related	MAP1LC3B MAP1LC3B2	7.29e-04	33	22	2	1022
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RPGRIP1 HECW2	8.68e-04	36	22	2	823
GeneFamily	PHD finger proteins	KDM5D KDM5C	5.31e-03	90	22	2	88
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Parm1-Excitatory_Neuron.Slc17a7.Parm1.Cadm2_(Deep_layer_pyramidal_cells--layer_5)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SPTBN5 ABCA13 GPX2	3.01e-06	34	37	3	c217c09c1d7e84f14b9e0d1e7c6e8e916b3c7d10
ToppCell	facs-Brain_Myeloid-Cortex-24m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPAN15 CTTNBP2 FAAH GPX2	1.44e-05	179	37	4	bc93883c2094f2e5bfed79facd4994a23968d875
ToppCell	facs-Brain_Myeloid-Cortex-24m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPAN15 CTTNBP2 FAAH GPX2	1.44e-05	179	37	4	0cef6d2eab2015cac0dd340532b24bfec9707330
ToppCell	facs-Brain_Myeloid-Cortex-24m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPAN15 CTTNBP2 FAAH GPX2	1.44e-05	179	37	4	bb2410b3934fcc53396b96b48e0d9843df159b89
ToppCell	facs-Brain_Myeloid-Cortex-24m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPAN15 CTTNBP2 FAAH GPX2	1.44e-05	179	37	4	065241799cea30da62cb3b6f2f1970bd1b0f4e2b
ToppCell	PCW_13-14\|World / Celltypes from embryonic and fetal-stage human lung	NCOR1 HPSE2 CTTNBP2 KDM5D	1.82e-05	190	37	4	62a3ec1ae0829602b0569cc051210551644f1d46
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	HPSE2 CTTNBP2 HECW2 NRP2	1.94e-05	193	37	4	9f69edc97b868d23998abc98928a2e89a885ef8a
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5D KDM5C	8.67e-06	4	36	2	DOID:0060809 (implicated_via_orthology)
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5D KDM5C	1.72e-04	16	36	2	DOID:0050888 (implicated_via_orthology)
Disease	Seizures, Focal	DYNC1H1 FAAH NRP2	2.79e-04	104	36	3	C0751495
Disease	autism spectrum disorder (implicated_via_orthology)	KDM5D KDM5C NRP2	8.45e-04	152	36	3	DOID:0060041 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLFFINNSFPLRNRA	ABCA13	2456	Q86UQ4
ANRIPANLLDQFERQ	DLGAP1	96	O14490
AEAFLRQQQAAPNLR	BMS1	676	Q14692
RLQCPFEQELLRRQQ	FAM107A	91	O95990
LEDFRNNRFPNLQLR	PUM2	711	Q8TB72
IIRRRLQLNANQAFF	MAP1LC3B	66	Q9GZQ8
ERFNNEQRLRLLQFV	HECW2	1486	Q9P2P5
DNFRFTPRVQRLNEL	KDM5D	61	Q9BY66
NDRTFPDDRNFLRLQ	NRP2	676	O60462
NDNPPRFSRQEQRLF	PCDHA5	126	Q9Y5H7
DFLQFQNLRNPAKSR	HPSE2	121	Q8WWQ2
RLLEDFRNNRYPNLQ	PUM1	831	Q14671
PRRRFNFFVLENNLE	DNAAF3	71	Q8N9W5
GRFNLNDPFLALQRD	CTTNBP2	76	Q8WZ74
LNPRIQAARFRFQGN	CTTNBP2	441	Q8WZ74
DLIFNQPDRRQLLNA	DCAKD	71	Q8WVC6
PRLLIAFQNRERQEQ	CBX4	51	O00257
NLSFRFARRNLNEPE	MARK2	646	Q7KZI7
RNGQRLLEKQRFQFP	DYNC1H1	1191	Q14204
NNPRNRDLFFRRLQA	C2orf66	51	Q6UXQ4
FLDLRQDQQNIRPLC	DCAF12L1	331	Q5VU92
QQQQRFSDLRELFAR	EXOC1	331	Q9NV70
DRAAQRFRLQNPDLD	FAAH	56	O00519
DFTQLNELQCRFPRR	GPX2	46	P18283
LSPNLNRFLGDRDFN	AFP	326	P02771
LLSRVFQPQNLREDR	PARS2	41	Q7L3T8
LDPQEQQGRRRFLFD	RPGRIP1	1181	Q96KN7
RRFPQNAFICQALAR	SAMD9L	1076	Q8IVG5
RNSDGEFLNRLNRFL	PNMA3	96	Q9UL41
RFLPLRDIQQEAFRA	ENTPD4	536	Q9Y227
QQQQLRRRPSLLSEF	NCOR1	61	O75376
FRLQTALQAQNRRPF	SPTBN5	371	Q9NRC6
NLLRFPNFTNQLLRR	TRAPPC11	1096	Q7Z392
IIRRRLQLNANQAFF	MAP1LC3B2	66	A6NCE7
FRNQTIDFLNDNIRR	TSPAN15	116	O95858
LERQFRSQAFNKLPQ	UBIAD1	296	Q9Y5Z9
LNRPGQELFRQLFRQ	ZNF445	46	P59923
DNFRFTPRIQRLNEL	KDM5C	61	P41229
ARERRFPNSELLQQL	KDM5C	801	P41229