Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	tRNA (cytidine-3-)-methyltransferase activity	METTL2A METTL2B	4.96e-05	4	58	2	GO:0052735
MousePheno	fused cornea and lens	TGFB2 AGAP5 AGAP9 AGAP1	1.24e-06	24	48	4	MP:0001307
Domain	Methyltransf_12	FASN METTL2A METTL2B	4.54e-07	6	54	3	PF08242
Domain	Methyltransf_12	FASN METTL2A METTL2B	4.54e-07	6	54	3	IPR013217
Domain	C2_Calpain	CAPN6 CAPN5	8.21e-06	2	54	2	IPR033884
Domain	MeTrfase	METTL2A METTL2B	4.90e-05	4	54	2	IPR026113
Domain	TGFb_propeptide	TGFB2 INHBC MSTN	7.11e-05	28	54	3	PF00688
Domain	TGF-b_N	TGFB2 INHBC MSTN	7.11e-05	28	54	3	IPR001111
Domain	ArfGap	AGAP5 AGAP9 AGAP1	7.92e-05	29	54	3	SM00105
Domain	ArfGap	AGAP5 AGAP9 AGAP1	7.92e-05	29	54	3	PF01412
Domain	ARFGAP	AGAP5 AGAP9 AGAP1	7.92e-05	29	54	3	PS50115
Domain	ArfGAP	AGAP5 AGAP9 AGAP1	7.92e-05	29	54	3	IPR001164
Domain	TGF-beta-rel	TGFB2 INHBC MSTN	1.07e-04	32	54	3	IPR015615
Domain	TGFb_CS	TGFB2 INHBC MSTN	1.07e-04	32	54	3	IPR017948
Domain	TGFB	TGFB2 INHBC MSTN	1.66e-04	37	54	3	SM00204
Domain	TGF-b_C	TGFB2 INHBC MSTN	1.66e-04	37	54	3	IPR001839
Domain	TGF_BETA_2	TGFB2 INHBC MSTN	1.66e-04	37	54	3	PS51362
Domain	TGF_beta	TGFB2 INHBC MSTN	1.66e-04	37	54	3	PF00019
Domain	TGF_BETA_1	TGFB2 INHBC MSTN	1.66e-04	37	54	3	PS00250
Domain	ARM-rpt_dom	GPRASP1 GPRASP2	4.44e-04	11	54	2	IPR006911
Domain	Arm_2	GPRASP1 GPRASP2	4.44e-04	11	54	2	PF04826
Domain	Calpain_III	CAPN6 CAPN5	5.32e-04	12	54	2	IPR022683
Domain	calpain_III	CAPN6 CAPN5	5.32e-04	12	54	2	SM00720
Domain	C2_III	CAPN6 CAPN5	5.32e-04	12	54	2	IPR033883
Domain	C2	CADPS CAPN6 CAPN5 CPNE4	5.57e-04	131	54	4	PF00168
Domain	Calpain_domain_III	CAPN6 CAPN5	6.27e-04	13	54	2	IPR022682
Domain	Calpain_III	CAPN6 CAPN5	6.27e-04	13	54	2	PF01067
Domain	C2	CADPS CAPN6 CAPN5 CPNE4	6.59e-04	137	54	4	SM00239
Domain	Calpain_cysteine_protease	CAPN6 CAPN5	7.30e-04	14	54	2	IPR022684
Domain	C2	CADPS CAPN6 CAPN5 CPNE4	7.54e-04	142	54	4	PS50004
Domain	CysPc	CAPN6 CAPN5	8.41e-04	15	54	2	SM00230
Domain	Peptidase_C2_calpain_cat	CAPN6 CAPN5	8.41e-04	15	54	2	IPR001300
Domain	Peptidase_C2	CAPN6 CAPN5	8.41e-04	15	54	2	PF00648
Domain	CALPAIN_CAT	CAPN6 CAPN5	8.41e-04	15	54	2	PS50203
Domain	-	TGFB2 INHBC MSTN	9.60e-04	67	54	3	2.10.90.10
Domain	Cystine-knot_cytokine	TGFB2 INHBC MSTN	9.60e-04	67	54	3	IPR029034
Domain	C2_dom	CADPS CAPN6 CAPN5 CPNE4	1.29e-03	164	54	4	IPR000008
Domain	zf-C2H2_6	ZNF154 ZNF316 ZFP28 ZNF181 ZNF445	2.10e-03	314	54	5	PF13912
Domain	HDc	HDDC3 PDE5A	2.17e-03	24	54	2	SM00471
Domain	HD/PDEase_dom	HDDC3 PDE5A	2.17e-03	24	54	2	IPR003607
Domain	Ricin_B_lectin	GALNTL6 MRC2	2.36e-03	25	54	2	PF00652
Domain	THIOL_PROTEASE_CYS	CAPN6 CAPN5	2.55e-03	26	54	2	PS00139
Domain	THIOL_PROTEASE_ASN	CAPN6 CAPN5	2.75e-03	27	54	2	PS00640
Domain	THIOL_PROTEASE_HIS	CAPN6 CAPN5	2.75e-03	27	54	2	PS00639
Domain	RICIN	GALNTL6 MRC2	2.96e-03	28	54	2	SM00458
Domain	RICIN_B_LECTIN	GALNTL6 MRC2	2.96e-03	28	54	2	PS50231
Domain	Pept_cys_AS	CAPN6 CAPN5	2.96e-03	28	54	2	IPR000169
Domain	Ricin_B_lectin	GALNTL6 MRC2	3.39e-03	30	54	2	IPR000772
Domain	KRAB	ZNF154 ZNF316 ZFP28 ZNF181 ZNF445	3.69e-03	358	54	5	PS50805
Domain	KRAB	ZNF154 ZNF316 ZFP28 ZNF181 ZNF445	3.69e-03	358	54	5	PF01352
Domain	KRAB	ZNF154 ZNF316 ZFP28 ZNF181 ZNF445	4.19e-03	369	54	5	SM00349
Domain	KRAB	ZNF154 ZNF316 ZFP28 ZNF181 ZNF445	4.24e-03	370	54	5	IPR001909
Domain	-	FASN METTL2A METTL2B	5.05e-03	120	54	3	3.40.50.150
Domain	SAM-dependent_MTases	FASN METTL2A METTL2B	5.29e-03	122	54	3	IPR029063
Domain	-	SHANK1 AGAP5 AGAP9 AGAP1	5.71e-03	248	54	4	1.25.40.20
Pubmed	Alternative binding modes identified for growth and differentiation factor-associated serum protein (GASP) family antagonism of myostatin.	GPRASP1 MSTN GPRASP2	1.76e-08	4	58	3	25657005
Pubmed	GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.	AGAP5 AGAP9 AGAP1	3.67e-07	9	58	3	12640130
Pubmed	AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.	AGAP5 AGAP9 AGAP1	5.24e-07	10	58	3	20664521
Pubmed	AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.	AGAP5 AGAP9 AGAP1	7.19e-07	11	58	3	15381706
Pubmed	The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.	AGAP5 AGAP9 AGAP1	1.24e-06	13	58	3	27713690
Pubmed	GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.	AGAP5 AGAP9 AGAP1	1.58e-06	14	58	3	22453919
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	SHANK1 ARHGAP6 AGAP5 CADPS APOB DEGS2 USPL1 LGALS3BP	2.13e-06	513	58	8	25798074
Pubmed	Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily.	CAPN6 CAPN5	2.73e-06	2	58	2	9503024
Pubmed	Directional ABCA1-mediated cholesterol efflux and apoB-lipoprotein secretion in the retinal pigment epithelium.	ABCA1 APOB	2.73e-06	2	58	2	30076206
Pubmed	Hepatic ABCA1 deficiency is associated with delayed apolipoprotein B secretory trafficking and augmented VLDL triglyceride secretion.	ABCA1 APOB	2.73e-06	2	58	2	28694219
Pubmed	Absence of hyperplasia in Gasp-1 overexpressing mice is dependent on myostatin up-regulation.	GPRASP1 MSTN	2.73e-06	2	58	2	25277978
Pubmed	Feto-maternal cholesterol transport regulated by β-Klotho-FGF15 axis is essential for fetal growth.	FASN LIPA APOB	4.18e-06	19	58	3	37541847
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SHANK1 GPRASP1 LURAP1 CADPS SGSM2 CHD9 KDM6B USPL1 GPRASP2 ZNF181 AGAP1	7.75e-06	1285	58	11	35914814
Pubmed	Respiratory failure, cleft palate and epilepsy in the mouse model of human Xq22.1 deletion syndrome.	GPRASP1 GPRASP2	8.19e-06	3	58	2	24569167
Pubmed	Recently reported familial hypercholesterolemia-related mutations from cases in the Middle East and North Africa region.	ABCA1 APOB	8.19e-06	3	58	2	30694837
Pubmed	A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution.	CAPN6 CAPN5	8.19e-06	3	58	2	9339374
Pubmed	Whole-Exome Sequencing of Patients With Posterior Segment Uveitis.	CAPN5 NOD2	8.19e-06	3	58	2	32707200
Pubmed	DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification.	METTL2A METTL2B	8.19e-06	3	58	2	32427860
Pubmed	A novel function of apolipoprotein E: upregulation of ATP-binding cassette transporter A1 expression.	ABCA1 APOB	1.64e-05	4	58	2	21779326
Pubmed	Strength training with blood flow restriction diminishes myostatin gene expression.	GPRASP1 MSTN	1.64e-05	4	58	2	21900845
Pubmed	Mstn knockdown decreases the trans-differentiation from myocytes to adipocytes by reducing Jmjd3 expression via the SMAD2/SMAD3 complex.	KDM6B MSTN	1.64e-05	4	58	2	31334687
Pubmed	Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6.	METTL2A METTL2B	1.64e-05	4	58	2	34268557
Pubmed	Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins.	METTL2A METTL2B	1.64e-05	4	58	2	11738826
Pubmed	The impact of APOA5, APOB, APOC3 and ABCA1 gene polymorphisms on ischemic stroke: Evidence from a meta-analysis.	ABCA1 APOB	1.64e-05	4	58	2	28865324
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	TGFB2 FASN CADPS GEMIN4 APOB GPRASP2 LGALS3BP	1.85e-05	496	58	7	31343991
Pubmed	Differential effects of extracellular ATP on chloride transport in cortical collecting duct cells.	CLCA2 SCNN1B	2.72e-05	5	58	2	22647633
Pubmed	Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans.	METTL2A METTL2B	2.72e-05	5	58	2	28655767
Pubmed	GPRASP proteins are critical negative regulators of hematopoietic stem cell transplantation.	GPRASP1 GPRASP2	2.72e-05	5	58	2	32027737
Pubmed	Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during development.	CAPN6 CAPN5	4.08e-05	6	58	2	10559499
Pubmed	KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting.	FASN ABCA1	4.08e-05	6	58	2	27545894
Pubmed	Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.	AGAP5 KCNA1 AGAP9 AGAP1	4.34e-05	116	58	4	30652415
Pubmed	Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1.	FASN APOB LGALS3BP	5.55e-05	44	58	3	31273033
Pubmed	Regulation of muscle mass by follistatin and activins.	INHBC MSTN	5.71e-05	7	58	2	20810712
Pubmed	Genetically Confirmed Familial Hypercholesterolemia in Patients With Acute Coronary Syndrome.	LIPA APOB	5.71e-05	7	58	2	28958330
Pubmed	Structure and physiological function of calpains.	CAPN6 CAPN5	5.71e-05	7	58	2	9396712
Pubmed	Intracellular lipidation of newly synthesized apolipoprotein A-I in primary murine hepatocytes.	ABCA1 APOB	5.71e-05	7	58	2	16204232
Pubmed	Genetic polymorphisms affecting the phenotypic expression of familial hypercholesterolemia.	ABCA1 APOB	7.60e-05	8	58	2	15135251
Pubmed	Altered gene expression for calpain/calpastatin system in motor neuron degeneration (Mnd) mutant mouse brain and spinal cord.	CAPN6 CAPN5	7.60e-05	8	58	2	9473662
Pubmed	A large-scale candidate gene association study of age at menarche and age at natural menopause.	TGFB2 INHBC SLC2A6 MSTN CHRNA4	9.70e-05	275	58	5	20734064
Pubmed	GASP-2 overexpressing mice exhibit a hypermuscular phenotype with contrasting molecular effects compared to GASP-1 transgenics.	GPRASP1 MSTN	9.77e-05	9	58	2	31960486
Pubmed	Polymorphisms associated with cholesterol and risk of cardiovascular events.	ABCA1 APOB	9.77e-05	9	58	2	18354102
Pubmed	A gene score of nine LDL and HDL regulating genes is associated with fluvastatin-induced cholesterol changes in women.	ABCA1 APOB	9.77e-05	9	58	2	19773416
Pubmed	TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population.	TGFB2 INHBC MSTN	1.09e-04	55	58	3	15342483
Pubmed	Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.	FASN ABCA1 LIPA	1.95e-04	67	58	3	16806233
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	LIPA DNAH17 CAPN6 CAPN5 METTL2A MMP15 METTL2B	2.07e-04	730	58	7	34857952
Pubmed	Nucleotide sequence of mouse spermidine synthase cDNA.	FASN APOB	2.11e-04	13	58	2	7803821
Pubmed	Identification of a novel family of G protein-coupled receptor associated sorting proteins.	GPRASP1 GPRASP2	2.46e-04	14	58	2	15086532
Pubmed	Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2.	GPRASP1 MSTN	2.83e-04	15	58	2	24019467
Pubmed	Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.	ABCA1 APOB	2.83e-04	15	58	2	20160193
Pubmed	Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.	FASN APOB	3.23e-04	16	58	2	8833906
Pubmed	Maternal and fetal variation in genes of cholesterol metabolism is associated with preterm delivery.	ABCA1 APOB	3.23e-04	16	58	2	17855807
Pubmed	Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease.	ABCA1 APOB	3.23e-04	16	58	2	20691829
Pubmed	Developmental changes in extracellular matrix messenger RNAs in the mouse placenta during the second half of pregnancy: possible factors involved in the regulation of placental extracellular matrix expression.	TGFB2 MSTN	3.23e-04	16	58	2	17881772
Pubmed	Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion.	FASN APOB	3.23e-04	16	58	2	38042368
Pubmed	Lp(a) and risk of recurrent cardiac events in obese postinfarction patients.	ABCA1 APOB	3.66e-04	17	58	2	18927546
Pubmed	Unravelling the complex genetics of cleft lip in the mouse model.	METTL2A METTL2B	4.59e-04	19	58	2	11353389
Pubmed	Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.	ABCA1 APOB	4.59e-04	19	58	2	19148283
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	AGAP5 AGAP9 QDPR AGAP1	4.89e-04	218	58	4	33378226
Pubmed	Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.	AGAP5 KCNA1 CPNE4 AGAP9 AGAP1	5.77e-04	405	58	5	38187761
Pubmed	Integrative predictive model of coronary artery calcification in atherosclerosis.	ABCA1 SCNN1B APOB CAPN5	5.88e-04	229	58	4	19948975
Pubmed	p16 Protein and gigaxonin are associated with the ubiquitination of NFκB in cisplatin-induced senescence of cancer cells.	ABCA1 MUC3A	6.18e-04	22	58	2	25331947
Pubmed	Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.	ABCA1 APOB	6.76e-04	23	58	2	22399527
Pubmed	Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events.	GPRASP1 GPRASP2	7.37e-04	24	58	2	16221301
Pubmed	A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice.	GPRASP1 GPRASP2	1.00e-03	28	58	2	23677977
Pubmed	Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population.	ABCA1 APOB	1.08e-03	29	58	2	20972250
Pubmed	Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk.	ABCA1 APOB	1.08e-03	29	58	2	20167577
Pubmed	Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.	TGFB2 MMP15	1.15e-03	30	58	2	21946350
Pubmed	Genetic associations of brain structural networks in schizophrenia: a preliminary study.	FASN APOB	1.23e-03	31	58	2	20691427
Pubmed	Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response.	ABCA1 APOB	1.23e-03	31	58	2	20031551
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	SHANK1 AGAP5 AGAP9 AGAP1	1.26e-03	281	58	4	28706196
Pubmed	Determination of genetic predisposition to patent ductus arteriosus in preterm infants.	ABCA1 APOB CHRNA4	1.33e-03	129	58	3	19336370
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	CADPS THSD7B CEMIP	1.36e-03	130	58	3	12421765
Pubmed	Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.	ABCA1 APOB	1.40e-03	33	58	2	18193044
Pubmed	Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.	ABCA1 APOB	1.48e-03	34	58	2	19060911
Pubmed	Newly identified loci that influence lipid concentrations and risk of coronary artery disease.	ABCA1 APOB	1.57e-03	35	58	2	18193043
Pubmed	Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection.	TGFB2 MMP15	1.66e-03	36	58	2	20587546
Interaction	CALCR interactions	GPRASP1 APOB GPRASP2	6.34e-06	13	58	3	int:CALCR
Cytoband	17q23.2	MRC2 METTL2A	8.36e-04	33	59	2	17q23.2
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	SGSM2 GEMIN4 SLC13A5 KDM6B	1.04e-03	346	59	4	chr17p13
Cytoband	17q25	FASN LGALS3BP	1.17e-03	39	59	2	17q25
Cytoband	Xq22.1	GPRASP1 GPRASP2	1.42e-03	43	59	2	Xq22.1
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	AGAP5 AGAP9 AGAP1	1.32e-05	17	50	3	1291
GeneFamily	ArfGAPs	AGAP5 AGAP9 AGAP1	1.02e-04	33	50	3	395
GeneFamily	C2 domain containing\|Calpains	CAPN6 CAPN5	7.69e-04	15	50	2	975
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	AGAP5 CADPS AGAP9 AGAP1	2.50e-03	206	50	4	682
GeneFamily	Methyltransferase like	METTL2A METTL2B	3.75e-03	33	50	2	963
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	CAPN6 CAPN5	4.45e-03	36	50	2	823
GeneFamily	Ankyrin repeat domain containing	SHANK1 AGAP5 AGAP9 AGAP1	4.45e-03	242	50	4	403
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	GPRASP1 GPRASP2	6.30e-03	43	50	2	409
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF717 ZNF154 ZNF316 ZFP28 ZNF181 ZNF445	1.38e-02	718	50	6	28
Coexpression	GSE411_WT_VS_SOCS3_KO_MACROPHAGE_IL6_STIM_400MIN_DN	HDDC3 SLC12A6 ABCA1 POLR3H JRK GEMIN4	5.33e-06	200	58	6	M5984
CoexpressionAtlas	DevelopingKidney_e14.5 whole kidney - Wnt4 KO_emap-6674_k-means-cluster#3_top-relative-expression-ranked_200	TGFB2 ABCA1 CADPS PDE5A	2.46e-06	35	58	4	gudmap_developingKidney_e14.5 whole kidney - Wnt4 KO_200_k3
ToppCell	BAL-Control-cDC_6\|Control / Compartment, Disease Groups and Clusters	GPRASP1 DNAH17 GEMIN4 CAPN5 DEGS2 CEMIP	9.48e-08	168	59	6	65ec473cff748b334c0a66e33bc34a8465fe7631
ToppCell	Biopsy_Control_(H.)-Epithelial-KRT5-/KRT17+\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	TGFB2 GALNTL6 MRC2 CAPN6 MMP15 MUC3A	2.57e-07	199	59	6	3b1f56c8b40bb36922a31d2d440a8c468a8aa3f1
ToppCell	facs-Lung-Endomucin-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFB2 SGSM2 SCNN1B PDE5A USPL1	2.99e-06	169	59	5	2d23b4cee060f8adddc430c1c10d4e25205b4af6
ToppCell	facs-Lung-Endomucin-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFB2 SGSM2 SCNN1B PDE5A USPL1	2.99e-06	169	59	5	ecaf08e8e0b54d1c97a02bc1f65409fd43d68227
ToppCell	facs-Lung-Endomucin-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFB2 SGSM2 SCNN1B PDE5A USPL1	2.99e-06	169	59	5	ad6af6609acf158cb79e45ee7ca9af332be3c40c
ToppCell	10x5'-Liver-Myeloid_Mac-Intestinal_macrophages\|Liver / Manually curated celltypes from each tissue	ABCA1 MRC2 SLC13A5 MMP15	5.46e-05	156	59	4	9a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TGFB2 ABCA1 CADPS MRC2	5.46e-05	156	59	4	bb505f639dbcad2b788db62d6084c2cb4e884bec
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	GALNTL6 CADPS THSD7B CPNE4	5.88e-05	159	59	4	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-AT1_Progenitor\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HDDC3 LURAP1 THSD7B ZNF181	6.17e-05	161	59	4	357c060e4d2ea1257c73b346dcd4a27dbc5db813
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Granulocytic-Mast_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ABCA1 CADPS SLC2A6 CHRNA4	6.17e-05	161	59	4	c54010d88f1ecb6e0235bb66084876a4d5bf1ecd
ToppCell	367C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)\|367C / Donor, Lineage, Cell class and subclass (all cells)	CLCA2 SCNN1B DEGS2 CPNE4	8.15e-05	173	59	4	d8e965ff7e9b758876ec1521c1ccedd739e8d673
ToppCell	367C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	CLCA2 SCNN1B DEGS2 CPNE4	8.15e-05	173	59	4	c2d973356c40e0284fd3bd7733a164b141c66008
ToppCell	(03)_Secretory-(0)_uninjured\|(03)_Secretory / shred by cell type and Timepoint	TGFB2 ARHGAP6 CAPN5 LGALS3BP	8.33e-05	174	59	4	ebdddb5091afcc49ab533c890f260f709880c5f9
ToppCell	COVID-19-kidney-PCT-S3-2\|kidney / Disease (COVID-19 only), tissue and cell type	FASN SLC13A5 APOB CHRNA4	8.33e-05	174	59	4	5aa2fb631505600f37d2b87b02def7be139dc262
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZNF154 CLCA2 APOB CAPN5	8.52e-05	175	59	4	1d1984a03d0f04cd06048ed62d123033af364e82
ToppCell	P15-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	LURAP1 KCNA1 SGSM2 ZNF316	8.71e-05	176	59	4	792f414f5092aba14260b8e16378e793a822498e
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 CADPS SCNN1B PDE5A	9.10e-05	178	59	4	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	10x5'-GI_large-bowel-Mast-Mast_cells\|GI_large-bowel / Manually curated celltypes from each tissue	ARHGAP6 ABCA1 CADPS AGAP1	9.10e-05	178	59	4	8fc5f735afa25ae43c2acb1c710ade6e9e093e3c
ToppCell	10x5'-GI_large-bowel-Mast\|GI_large-bowel / Manually curated celltypes from each tissue	ARHGAP6 ABCA1 CADPS AGAP1	9.10e-05	178	59	4	d10ed2543c96e1a2373f847e0b82144771e26d07
ToppCell	3'_v3-bone_marrow-Myeloid_Mac-Macrophage\|bone_marrow / Manually curated celltypes from each tissue	ARHGAP6 ABCA1 LIPA LGALS3BP	9.10e-05	178	59	4	11a338032b59b936c5e65517c4160f7dd47a2cda
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFB2 LURAP1 SCNN1B CAPN5	9.70e-05	181	59	4	7af469f5bcb9b1ab3f35b2758bf2afb87e8eba57
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TGFB2 GALNTL6 THSD7B CHRNA4	9.70e-05	181	59	4	2f3d04d22d4ac016e61709ea5af3d48885c946c4
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIPA APOB QDPR CHRNA4	1.01e-04	183	59	4	92f54c267135cb5edbcacd26a0f29e62469bb7e5
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIPA APOB QDPR CHRNA4	1.01e-04	183	59	4	5c4f7d02ba3a3c4a22ac71302e7c9a47e205eef5
ToppCell	Control-Epithelial_cells-Airway_mucous\|Control / group, cell type (main and fine annotations)	CAPN5 MUC3A AGAP1 CEMIP	1.01e-04	183	59	4	15d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIPA APOB QDPR CHRNA4	1.06e-04	185	59	4	3e3217c99719fd1d2fa94e16be7712a7e5077152
ToppCell	droplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABCA1 LIPA QDPR AGAP1	1.06e-04	185	59	4	4bee178ede12f56ba5f5bec44a03dc2a62c50137
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIPA APOB QDPR CHRNA4	1.06e-04	185	59	4	0ff4148b4701003d9d594e0da8261176fb13aa59
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TGFB2 GALNTL6 THSD7B CHRNA4	1.10e-04	187	59	4	02105c82a9ba79d2f19e002188377fc3440770c2
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TGFB2 ABCA1 SCNN1B MUC3A	1.12e-04	188	59	4	e9cef856a96a97afac5ecafe2ee91eff0d731e01
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 CADPS SCNN1B PDE5A	1.12e-04	188	59	4	a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FASN MRC2 KDM6B MUC3A	1.15e-04	189	59	4	da014519d6eb21bc2dc2ed65eafe638b42a068ed
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 CADPS SCNN1B PDE5A	1.22e-04	192	59	4	5b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	TGFB2 DEGS2 MMP15 AGAP1	1.22e-04	192	59	4	8899d81306770adda893b5e146df1253971754c5
ToppCell	AT1_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	TGFB2 ABCA1 CAPN6 SCNN1B	1.22e-04	192	59	4	0444f9e9cef7403e220e862b5a787443d3f5c9ac
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SCNN1B DEGS2 MMP15 LGALS3BP	1.22e-04	192	59	4	967122c53af25b8f19a8411b4553d764c8d51c4d
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	TGFB2 DEGS2 MMP15 AGAP1	1.22e-04	192	59	4	5fda9a465c9f77c7fa1a3ea07a2b0374bbc23b2a
ToppCell	distal-3-Hematologic-Basophil/Mast_2\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MALRD1 CADPS KDM6B AGAP1	1.24e-04	193	59	4	23c6c798525dad43eff792727902ea562bf373be
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLCA2 SCNN1B MMP15 IFT43	1.24e-04	193	59	4	22ebc3f586eb0aabc5785e468c88d7416c624ff4
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDE5A THSD7B MSTN CHRNA4	1.27e-04	194	59	4	91205b22650e7ecdb72bb59348ce2530b76c532c
ToppCell	COVID_vent-Myeloid-Monocytic-CD16+_Monocyte\|COVID_vent / Disease condition, Lineage, Cell class and subclass	ABCA1 LIPA SLC2A6 LGALS3BP	1.27e-04	194	59	4	b133d3d198360269cc449a75d34c29be377d91e0
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDE5A THSD7B MSTN CHRNA4	1.27e-04	194	59	4	6e12a7da35be4c0ecf998ef94b8989b89d74b200
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLCA2 SCNN1B DEGS2 LGALS3BP	1.27e-04	194	59	4	40251e6415a62fa55d86f2e8609bf0402e1c1abb
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDE5A THSD7B MSTN CHRNA4	1.27e-04	194	59	4	c52f10140c66e8c0566421c3d535d5d92bf595e1
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ABCA1 MRC2 LGALS3BP CEMIP	1.32e-04	196	59	4	b8b9801181d7604871b48aebacb295d0a57a5eaf
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Macroglial-Astrocyte\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	TGFB2 MRC2 SLC13A5 LGALS3BP	1.32e-04	196	59	4	55a10faafcbe075eefdfcd7cff25ded040c23538
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Macroglial\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	TGFB2 MRC2 SLC13A5 LGALS3BP	1.32e-04	196	59	4	8025ec8aee8455c7b0261aa4a0caacebd2f50634
ToppCell	Tracheal-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	GPRASP1 MRC2 CAPN6 THSD7B	1.40e-04	199	59	4	fbec5c034576cb1adaf05f6f97cc5525d19e0c1b
ToppCell	Parenchymal-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MRC2 ZFP28 IFT43 ZNF445	1.42e-04	200	59	4	36de49593cf6ff1c9229fcceb150c1d68658a360
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Intermediate\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	GALNTL6 FASN KCNA1 CADPS	1.42e-04	200	59	4	a3fcd901cb281920f1bafdfd676399a6dc37355e
Disease	cerebral palsy (implicated_via_orthology)	AGAP5 AGAP9 AGAP1	6.89e-07	10	54	3	DOID:1969 (implicated_via_orthology)
Disease	Hypercholesterolemia	ABCA1 LIPA APOB	5.05e-05	39	54	3	C0020443
Disease	Hyperlipoproteinemia Type IIb	ABCA1 APOB	2.53e-04	13	54	2	C1704417
Disease	Hyperlipoproteinemia Type IIa	ABCA1 APOB	3.88e-04	16	54	2	C0745103
Disease	Hypercholesterolemia, Familial	ABCA1 APOB	4.94e-04	18	54	2	C0020445
Disease	susceptibility to pneumonia measurement	ARHGAP6 MALRD1 SLC2A6	7.56e-04	97	54	3	EFO_0008410
Disease	coronary artery disease (is_implicated_in)	ABCA1 APOB NOD2	8.26e-04	100	54	3	DOID:3393 (is_implicated_in)
Disease	Alzheimer disease, high density lipoprotein cholesterol measurement	ABCA1 APOB	1.04e-03	26	54	2	EFO_0004612, MONDO_0004975
Disease	cholesteryl esters to total lipids in large LDL percentage	ABCA1 APOB	1.48e-03	31	54	2	EFO_0022249
Disease	triglyceride measurement, high density lipoprotein cholesterol measurement	GALNTL6 ABCA1 MALRD1 APOB	1.60e-03	274	54	4	EFO_0004530, EFO_0004612
Disease	fatty liver disease (biomarker_via_orthology)	ABCA1 APOB	1.67e-03	33	54	2	DOID:9452 (biomarker_via_orthology)
Disease	phosphatidylcholine measurement	ABCA1 MALRD1 APOB THSD7B	1.82e-03	284	54	4	EFO_0010226

Protein segments in the cluster

Peptide	Gene	Start	Entry
LDFWESGEWVIVDAV	CHRNA4	201	P43681
WHFEATTYEERDAWV	AGAP1	566	Q9UPQ3
WHFEATTYEERDAWV	AGAP9	466	Q5VTM2
DHFWEQQLDGLDWTA	ABCA1	446	O95477
FHFHFWRFGEWVDVV	CAPN5	121	O15484
SWTPLEFLVETFHDW	QDPR	201	P09417
QDVEWTEWFDHDKVS	CEMIP	321	Q8WUJ3
HWKEEFTWLDFDYER	C17orf113	26	A0A1B0GUU1
AEPHVDKGEAFAWWS	CADPS	901	Q9ULU8
EAESHFSSIPDAFWW	KCNA1	351	Q09470
DTWSWGERASHEEVE	LGALS3BP	326	Q08380
EFFVDFREIGWHDWI	INHBC	251	P55103
EGWSEHRVQEYFEWA	HDDC3	136	Q8N4P3
DGFETSWDDWKPEIH	KIAA1109	3396	Q2LD37
WWEPTGHTFFFQEDR	MMP15	471	P51511
GDCEWFAVHEHYWET	KDM6B	1406	O15054
WVDKEIFSDWFHHIF	JRK	261	O75564
FETWDEEVVGTFSNW	MUC3A	3271	Q02505
DQDSVEAWLDDHWDF	PDE5A	26	O76074
VFHHNAWDNVEWSEE	METTL2B	31	Q6P1Q9
DESAKLGFEAHWFWE	LURAP1	216	Q96LR2
LGFEAHWFWEQCQDD	LURAP1	221	Q96LR2
FGESEPEIHEQHWFW	MRC2	731	Q9UBG0
WLRGTDVDVHWEFEQ	SLC2A6	236	Q9UGQ3
VFHHNAWDNVEWSEE	METTL2A	31	Q96IZ6
DLSEEPFDIWGTWHS	ARHGAP6	726	O43182
CDWFEAISGDHFDWI	MALRD1	661	Q5VYJ5
AWHYDEEKIEFEWNT	APOB	1166	P04114
DHSEVPAEWWDFDAD	CHD9	1666	Q3L8U1
EVREDDVGWDWDHLF	IFT43	166	Q96FT9
DVGWDWDHLFTEVSS	IFT43	171	Q96FT9
CTAIDWFHEWPEDAL	DNAH17	2951	Q9UFH2
WFHEWPEDALVSVSA	DNAH17	2956	Q9UFH2
WDWDSNGKHDFIGEF	CPNE4	231	Q96A23
HSWVKVLWDFVFEDS	DEGS2	291	Q6QHC5
WDHSLAWDVPAAEDF	FASN	836	P49327
FHFRFWHFGEWTEVV	CAPN6	121	Q9Y6Q1
WHFGEWTEVVIDDLL	CAPN6	126	Q9Y6Q1
FSEGNIDVWWIVHDG	SLC12A6	906	Q9UHW9
TWGRAIFDLDHFPDW	SLC13A5	546	Q86YT5
DWPSEASEDWIFHVL	SCNN1B	461	P51168
EEALIGTWFWATDES	GPRASP1	401	Q5JY77
DESIIGSWFWTEEEA	GPRASP1	431	Q5JY77
EAEEETIFGSWFWVI	GPRASP1	511	Q5JY77
TEEETIFGSWFWDGK	GPRASP1	901	Q5JY77
IFGSWFWDGKEVSEE	GPRASP1	906	Q5JY77
DEDEAIVGSWFWAGD	GPRASP1	996	Q5JY77
IVGSWFWAGDEAHFE	GPRASP1	1001	Q5JY77
TWSHEQLFTFGWRED	GALNTL6	491	Q49A17
PESEEEAIFGSWFWD	GPRASP2	441	Q96D09
LTVDFEAFGWDWIIA	MSTN	286	O14793
EDVFAVWEVIWAARH	SGSM2	926	O43147
SFVGVIWDVFLWDHV	MPTX1	86	A8MV57
VWVWEYETEEGAHDL	POLR3H	126	Q9Y535
FDVADWLEWLGLAEH	SHANK1	2101	Q9Y566
WHFEATTYEERDAWV	AGAP5	421	A6NIR3
VFVHEWAHLRWGVFD	CLCA2	161	Q9UQC9
GEWLSFDVTDAVHEW	TGFB2	196	P61812
GDVAVDFSQEEWEWL	ZFP28	106	Q8NHY6
HFITWILDADGSWLE	USPL1	456	Q5W0Q7
LSWEVLSWEDYEGFH	NOD2	61	Q9HC29
EVAVHFTWEEWQDLD	ZNF717	26	Q9BY31
FKDVEVTFSQDEWGW	ZNF445	236	P59923
GAWFWTDDIEDHEEE	ZNF316	236	A6NFI3
FEDVAVHFSWEEWGL	ZNF154	16	Q13106
VHFSWEEWGLLDEAQ	ZNF154	21	Q13106
VCDWHSDLFQWEVSD	THSD7B	96	Q9C0I4
WESFAEWGEDLEVNI	TMX1	66	Q9H3N1
FNDVAIDFTHEEWGW	ZNF181	6	Q2M3W8
DTSAEDVAFFLDVWW	GEMIN4	151	P57678
HESIPEWEHLDFIWG	LIPA	366	P38571