Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentAP-type membrane coat adaptor complex

AP1B1 AP2B1 AP1G1 VPS18 AP5B1

6.98e-05481885GO:0030119
GeneOntologyCellularComponentclathrin vesicle coat

AP1B1 AP2B1 AP1G1 EPN3

3.68e-04381884GO:0030125
GeneOntologyCellularComponentclathrin-coated vesicle membrane

AVP FZD4 AP1B1 AP2B1 AP1G1 OTOF EPN3

3.76e-041471887GO:0030665
GeneOntologyCellularComponentcoated membrane

AP1B1 AP2B1 AP1G1 EPN3 VPS18 AP5B1

3.96e-041061886GO:0048475
GeneOntologyCellularComponentmembrane coat

AP1B1 AP2B1 AP1G1 EPN3 VPS18 AP5B1

3.96e-041061886GO:0030117
GeneOntologyCellularComponentvacuole

GALNS TTC3 AP1B1 AP2B1 AP1G1 NOS1 VPS18 HYAL1 SGSH ARL8A APP PLBD2 KPTN SLC17A5 CD1C SLC11A1 NAPRT AP5B1 ULK2

6.00e-0491318819GO:0005773
GeneOntologyCellularComponentexocyst

EXOC3L1 TNFAIP2 EXOC4

8.45e-04211883GO:0000145
GeneOntologyCellularComponentextracellular matrix

LRRC3C FREM1 HMCN2 NID1 LRRN2 FLRT1 GP1BA COL27A1 RTN4RL1 CHADL LMAN1L ANGPTL6 IGFALS HMCN1 ADAMTS14

9.01e-0465618815GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

LRRC3C FREM1 HMCN2 NID1 LRRN2 FLRT1 GP1BA COL27A1 RTN4RL1 CHADL LMAN1L ANGPTL6 IGFALS HMCN1 ADAMTS14

9.29e-0465818815GO:0030312
GeneOntologyCellularComponentstereocilium tip

CDH23 STRC ESPNL

9.72e-04221883GO:0032426
GeneOntologyCellularComponentlysosome

GALNS AP1B1 AP2B1 AP1G1 NOS1 VPS18 HYAL1 SGSH ARL8A APP PLBD2 KPTN SLC17A5 CD1C SLC11A1 NAPRT AP5B1

1.08e-0381118817GO:0005764
GeneOntologyCellularComponentlytic vacuole

GALNS AP1B1 AP2B1 AP1G1 NOS1 VPS18 HYAL1 SGSH ARL8A APP PLBD2 KPTN SLC17A5 CD1C SLC11A1 NAPRT AP5B1

1.08e-0381118817GO:0000323
GeneOntologyCellularComponentextrinsic component of membrane

GRIPAP1 CYTH1 CDH23 AP2B1 CARMIL2 PLEKHG4B DCHS1 SCRIB

1.16e-032301888GO:0019898
GeneOntologyCellularComponentcochlear hair cell ribbon synapse

CDH23 OTOF

1.18e-0361882GO:0098683
GeneOntologyCellularComponentclathrin-coated vesicle

AVP FZD4 AP1B1 AP2B1 AP1G1 OTOF EPN3 VPS18

1.41e-032371888GO:0030136
GeneOntologyCellularComponentextrinsic component of plasma membrane

CYTH1 CDH23 AP2B1 CARMIL2 DCHS1 SCRIB

1.52e-031371886GO:0019897
GeneOntologyCellularComponentcoated vesicle

AVP FZD4 AP1B1 AP2B1 AP1G1 OTOF EPN3 VPS18 APP LMAN1L

1.61e-0336018810GO:0030135
GeneOntologyCellularComponentclathrin coat

AP1B1 AP2B1 AP1G1 EPN3

1.62e-03561884GO:0030118
DomainLeu-rich_rpt

LRRC3C PIDD1 LRRC47 LRRC26 NLRC5 LRRN2 FLRT1 NLRC3 GP1BA CARMIL2 RTN4RL1 CHADL IGFALS SCRIB

5.85e-0727118614IPR001611
DomainLRR_8

LRRC3C PIDD1 LRRC47 LRRC26 LRRN2 FLRT1 GP1BA RTN4RL1 CHADL IGFALS SCRIB

1.18e-0617118611PF13855
DomainLRR_TYP

LRRC3C PIDD1 LRRC47 LRRC26 LRRN2 FLRT1 GP1BA RTN4RL1 CHADL IGFALS SCRIB

1.65e-0617718611SM00369
DomainLeu-rich_rpt_typical-subtyp

LRRC3C PIDD1 LRRC47 LRRC26 LRRN2 FLRT1 GP1BA RTN4RL1 CHADL IGFALS SCRIB

1.65e-0617718611IPR003591
DomainG2F

HMCN2 NID1 HMCN1

3.86e-0641863PF07474
DomainNIDOGEN_G2

HMCN2 NID1 HMCN1

3.86e-0641863PS50993
DomainGFP

HMCN2 NID1 HMCN1

3.86e-0641863IPR009017
DomainG2_nidogen/fibulin_G2F

HMCN2 NID1 HMCN1

3.86e-0641863IPR006605
Domain-

LRRC3C PIDD1 LRRC47 LRRC26 NLRC5 LRRN2 FLRT1 NLRC3 GP1BA CARMIL2 RTN4RL1 CHADL IGFALS SCRIB

4.29e-06321186143.80.10.10
DomainL_dom-like

LRRC3C PIDD1 LRRC47 LRRC26 NLRC5 LRRN2 FLRT1 NLRC3 GP1BA CARMIL2 RTN4RL1 CHADL IGFALS SCRIB

5.49e-0632818614IPR032675
DomainLRR

LRRC3C PIDD1 LRRC47 NLRC5 LRRN2 FLRT1 GP1BA RTN4RL1 CHADL IGFALS SCRIB

5.66e-0620118611PS51450
DomainLRRNT

LRRC3C LRRC26 LRRN2 FLRT1 GP1BA RTN4RL1 CHADL IGFALS

6.10e-06981868IPR000372
DomainLRRNT

LRRC3C LRRC26 LRRN2 FLRT1 GP1BA RTN4RL1 CHADL IGFALS

6.10e-06981868SM00013
DomainLRR_1

LRRC3C PIDD1 LRRC47 LRRC26 NLRC5 LRRN2 FLRT1 RTN4RL1 CHADL IGFALS SCRIB

1.27e-0521918611PF00560
Domain-

PLEC DSP MACF1

1.90e-05618633.90.1290.10
DomainCys-rich_flank_reg_C

LRRC26 LRRN2 FLRT1 GP1BA RTN4RL1 CHADL IGFALS

3.23e-05901867IPR000483
DomainLRRCT

LRRC26 LRRN2 FLRT1 GP1BA RTN4RL1 CHADL IGFALS

3.23e-05901867SM00082
DomainPlectin

PLEC DSP MACF1

3.30e-0571863PF00681
DomainPlectin_repeat

PLEC DSP MACF1

3.30e-0571863IPR001101
DomainPLEC

PLEC DSP MACF1

3.30e-0571863SM00250
DomainARM-type_fold

INTS1 CUL9 UNC45A URB1 AP1B1 AP2B1 AP1G1 TARBP1 TOGARAM2 HEATR5A WDFY4 MROH6 IPO13

3.68e-0533918613IPR016024
DomainAlpha_adaptinC2

AP1B1 AP2B1 AP1G1

7.81e-0591863PF02883
DomainClathrin_a/b/g-adaptin_app_Ig

AP1B1 AP2B1 AP1G1

7.81e-0591863IPR008152
DomainAlpha_adaptinC2

AP1B1 AP2B1 AP1G1

7.81e-0591863SM00809
Domain-

CUL9 UNC45A AP1B1 AP2B1 AP1G1 TOGARAM2 HEATR5A WDFY4 MROH6 IPO13

7.96e-05222186101.25.10.10
DomainARM-like

CUL9 UNC45A AP1B1 AP2B1 AP1G1 TARBP1 TOGARAM2 HEATR5A WDFY4 MROH6 IPO13

8.64e-0527018611IPR011989
DomainClathrin_b-adaptin_app_Ig-like

AP1B1 AP2B1

9.86e-0521862IPR013037
Domain-

AP1B1 AP2B1

9.86e-05218622.60.40.1150
DomainCadherin

CDH23 FREM1 PCDHGB3 PCDHGA3 PCDHGA2 PCDH20 DCHS1

1.80e-041181867IPR002126
DomainCoatomer/clathrin_app_Ig-like

AP1B1 AP2B1 AP1G1

2.00e-04121863IPR013041
DomainAlkaline_phosphatase_core

GALNS ALPI SGSH ARSL

2.43e-04311864IPR017850
DomainAlkaline_Pase-like_a/b/a

GALNS ALPI SGSH ARSL

2.43e-04311864IPR017849
Domain-

GALNS ALPI SGSH ARSL

2.43e-043118643.40.720.10
DomainCul7

CUL9 HERC2

2.94e-0431862PF11515
DomainNO_synthase

NOS1 NOS3

2.94e-0431862PF02898
DomainAP_complex_bsu_1_2_4

AP1B1 AP2B1

2.94e-0431862IPR016342
DomainNOS_euk

NOS1 NOS3

2.94e-0431862IPR012144
DomainCPH_domain

CUL9 HERC2

2.94e-0431862IPR021097
Domain-

NOS1 NOS3

2.94e-04318623.90.340.10
DomainG2F

NID1 HMCN1

2.94e-0431862SM00682
DomainSpoU_MeTrfase

MRM1 TARBP1

2.94e-0431862IPR001537
DomainSpoU_methylase

MRM1 TARBP1

2.94e-0431862PF00588
DomainNOS_N

NOS1 NOS3

2.94e-0431862IPR004030
DomainNOS

NOS1 NOS3

2.94e-0431862PS60001
DomainB2-adapt-app_C

AP1B1 AP2B1

2.94e-0431862PF09066
DomainClathrin/coatomer_adapt-like_N

AP1B1 AP2B1 AP1G1

4.05e-04151863IPR002553
DomainAdaptin_N

AP1B1 AP2B1 AP1G1

4.05e-04151863PF01602
DomainSulfatase_CS

GALNS SGSH ARSL

4.95e-04161863IPR024607
Domain-

MRM1 TARBP1

5.84e-04418623.40.1280.10
DomainB2-adapt-app_C

AP1B1 AP2B1

5.84e-0441862SM01020
DomaintRNA_m1G_MTases_N

MRM1 TARBP1

5.84e-0441862IPR029026
DomainB-adaptin_app_sub_C

AP1B1 AP2B1

5.84e-0441862IPR015151
DomainSULFATASE_1

GALNS SGSH ARSL

5.96e-04171863PS00523
DomainSULFATASE_2

GALNS SGSH ARSL

5.96e-04171863PS00149
DomainUIM

ANKRD13B DNAJB2 EPN3

7.10e-04181863PF02809
DomainSulfatase

GALNS SGSH ARSL

7.10e-04181863PF00884
DomainSulfatase_N

GALNS SGSH ARSL

7.10e-04181863IPR000917
DomainCadherin_CS

CDH23 PCDHGB3 PCDHGA3 PCDHGA2 PCDH20 DCHS1

7.80e-041091866IPR020894
DomainCADHERIN_1

CDH23 PCDHGB3 PCDHGA3 PCDHGA2 PCDH20 DCHS1

9.42e-041131866PS00232
DomainCadherin

CDH23 PCDHGB3 PCDHGA3 PCDHGA2 PCDH20 DCHS1

9.42e-041131866PF00028
DomainFYrich_C

KMT2C KMT2D

9.67e-0451862IPR003889
DomainFYrich_N

KMT2C KMT2D

9.67e-0451862IPR003888
DomainAP_beta

AP1B1 AP2B1

9.67e-0451862IPR026739
DomainFYRC

KMT2C KMT2D

9.67e-0451862SM00542
DomainFYRN

KMT2C KMT2D

9.67e-0451862SM00541
DomainEXOC3/Sec6

EXOC3L1 TNFAIP2

9.67e-0451862IPR010326
DomainSec6

EXOC3L1 TNFAIP2

9.67e-0451862PF06046
DomainFYRN

KMT2C KMT2D

9.67e-0451862PF05964
DomainFYRC

KMT2C KMT2D

9.67e-0451862PF05965
DomainFYRC

KMT2C KMT2D

9.67e-0451862PS51543
DomainFYRN

KMT2C KMT2D

9.67e-0451862PS51542
DomainCADHERIN_2

CDH23 PCDHGB3 PCDHGA3 PCDHGA2 PCDH20 DCHS1

9.86e-041141866PS50268
Domain-

CDH23 PCDHGB3 PCDHGA3 PCDHGA2 PCDH20 DCHS1

9.86e-0411418662.60.40.60
DomainCA

CDH23 PCDHGB3 PCDHGA3 PCDHGA2 PCDH20 DCHS1

1.03e-031151866SM00112
DomainCadherin-like

CDH23 PCDHGB3 PCDHGA3 PCDHGA2 PCDH20 DCHS1

1.08e-031161866IPR015919
DomainUIM

ANKRD13B DNAJB2 EPN3

1.13e-03211863SM00726
DomainFAD_binding_1

NOS1 NOS3

1.44e-0361862PF00667
Domain-

NOS1 NOS3

1.44e-03618621.20.990.10
DomainAlpha/beta_knot_MTases

MRM1 TARBP1

1.44e-0361862IPR029028
DomainFAD-binding_1

NOS1 NOS3

1.44e-0361862IPR003097
DomainNADPH_Cyt_P450_Rdtase_dom3

NOS1 NOS3

1.44e-0361862IPR023173
DomainBeta2_adaptin/TBP_C_dom

AP1B1 AP2B1

1.44e-0361862IPR012295
Domain-

AP1B1 AP2B1

1.44e-03618623.30.310.10
DomainUIM

ANKRD13B DNAJB2 EPN3

1.69e-03241863PS50330
DomainUIM_dom

ANKRD13B DNAJB2 EPN3

1.90e-03251863IPR003903
DomainLRRNT

FLRT1 GP1BA RTN4RL1 IGFALS

1.91e-03531864PF01462
DomainAPC_su10/DOC_dom

CUL9 HERC2

2.00e-0371862IPR004939
DomainDOC

CUL9 HERC2

2.00e-0371862PS51284
DomainANAPC10

CUL9 HERC2

2.00e-0371862PF03256
DomainAPC10

CUL9 HERC2

2.00e-0371862SM01337
DomainFlavodoxin/NO_synth

NOS1 NOS3

2.66e-0381862IPR008254
DomainFlavdoxin-like

NOS1 NOS3

2.66e-0381862IPR001094
DomainCoatomer/calthrin_app_sub_C

AP1B1 AP2B1

2.66e-0381862IPR009028
DomainFLAVODOXIN_LIKE

NOS1 NOS3

2.66e-0381862PS50902
DomainFlavodoxin_1

NOS1 NOS3

2.66e-0381862PF00258
DomainSpectrin_repeat

PLEC DSP MACF1

2.93e-03291863IPR002017
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TMEM94 CYTH1 INTS1 PEX6 CUL9 ANKLE1 TTC3 GADD45A KMT2C URB1 MDN1 UBN1 TMCC2 MCM3AP NLRC5 MICAL3 PLEC HERC2 EPN3 PLXNA3 POLG CEP192 KMT2D MROH6 NAPRT TNFAIP2 ULK2 PRRT4

2.26e-1111051932835748872
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

DDX47 INTS1 UNC45A TUBGCP4 LRRC47 MDN1 UBN1 AP1B1 UMPS PLEC MVP KIF27 DSP MACF1 TNFAIP2 SCRIB CPSF3 EXOC4

5.19e-095821931820467437
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

INTS1 CUL9 URB2 LRRC47 URB1 MDN1 AP1B1 AP2B1 MCM3AP DDX54 PLEC HERC2 MVP DSP NOL11 MACF1 CPSF3 FTSJ3

3.01e-086531931822586326
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

DDX47 MCM3 URB2 UNC45A LRRC47 URB1 MDN1 UBN1 AP2B1 AP1G1 MCM3AP DDX54 PLEC HERC2 MVP DSP IARS1 NOL11 SLC25A12 MACF1 SCRIB CPSF3 EXOC4 FTSJ3

5.65e-0713531932429467282
Pubmed

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

LAYN INTS1 CDH23 CA14 BPIFA1 ENKD1 TMCC2 LRRN2 FLRT1 SH2D3A ESPNL ATP13A5 FAM131A SHISA4 SEZ6L2 LMAN1L ANGPTL6 OIT3 SCPEP1 HSD17B14

6.87e-079851932012975309
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

GRIPAP1 LCMT2 TTBK1 TMCC2 MICAL3 VPS18 COL27A1 WDFY4 VPS13D DNAH17 MACF1 UNC80 EXOC4

4.32e-064931931315368895
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

DDX47 INTS1 MCM3 URB2 URB1 MDN1 PRDX3 DDX54 PLEC HERC2 TAP1 DSP IARS1 NOL11 APP CNNM3 MACF1 SCRIB FTSJ3

4.88e-0610241931924711643
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

URB2 UNC45A LRRC47 URB1 LMF2 AP1B1 AP1G1 UMPS DNAJB2 TARBP1 IARS1 SGSH APP SLC4A2 CNNM3 SLC25A12 SCRIB EXOC4

5.89e-069421931831073040
Pubmed

Defining the membrane proteome of NK cells.

DDX47 INTS1 MCM3 TUBGCP4 LMF2 MDN1 AP2B1 AP1G1 DDX54 HERC2 MVP TAP1 CARMIL2 IARS1 MYO18A ARL8A SLC4A2 CNNM3 MAP4K1 EXOC4

8.86e-0611681932019946888
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

BCKDHA UNC45A TTC3 LCMT2 LRRC47 URB1 MDN1 DDX54 AK4 HERC2 DNAJB2 MYO18A NOL11 CEP192 RAB11FIP1 APP ATF6B SLC4A2 CNNM3 MACF1 SCRIB EXOC4 FTSJ3

9.51e-0614871932333957083
Pubmed

A mouse knockout library for secreted and transmembrane proteins.

LAYN INTS1 LRRN2 FLRT1 ATP13A5 FAM131A SHISA4 SEZ6L2 LMAN1L OIT3 SCPEP1 HSD17B14

1.13e-054601931220562862
Pubmed

Clint: a novel clathrin-binding ENTH-domain protein at the Golgi.

AP1B1 AP2B1 AP1G1

1.38e-059193312429846
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

MCM3 UNC45A LRRC47 MDN1 AP1B1 AP2B1 AP1G1 UMPS PLEC IARS1 NOL11 SCRIB CPSF3 EXOC4

1.48e-056381931433239621
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TMEM94 CUL9 URB2 STARD9 MCM3AP MICAL3 HEATR5A CEP192 MACF1 SCRIB ULK2

1.91e-054071931112693553
Pubmed

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.

CDH23 FREM1 PLEC COL27A1 SLC25A12 HMCN1 MACF1

2.38e-05152193734299191
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

DDX47 MRM1 KMT2C MDN1 DDX54 NID1 MICAL3 PLCB4 TOGARAM2 VPS13D SLC25A12 SH3RF3

2.42e-054971931236774506
Pubmed

Functional proteomics mapping of a human signaling pathway.

PEX6 UNC45A TTC3 AP1B1 AP1G1 MCM3AP NID1 PLEC HERC2 DNAJB2 EPN3 KMT2D MACF1

2.92e-055911931315231748
Pubmed

Differential roles of neuronal and endothelial nitric oxide synthases during carrageenan-induced inflammatory hyperalgesia.

NOS1 NOS3

3.06e-052193215350652
Pubmed

Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling.

NOS1 NOS3

3.06e-052193224643800
Pubmed

Intron 4 polymorphism of the endothelial nitric oxide synthase gene is associated with the development of lupus nephritis.

NOS1 NOS3

3.06e-052193215119548
Pubmed

Modulation of the myogenic response in renal blood flow autoregulation by NO depends on endothelial nitric oxide synthase (eNOS), but not neuronal or inducible NOS.

NOS1 NOS3

3.06e-052193221825026
Pubmed

Endothelial nitric oxide modulates expression and processing of amyloid precursor protein.

NOS3 APP

3.06e-052193221127294
Pubmed

Chronic NOS inhibition actuates endothelial-mesenchymal transformation.

NOS1 NOS3

3.06e-052193216963618
Pubmed

Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice.

NOS1 NOS3

3.06e-05219328667023
Pubmed

nNOS and eNOS modulate cGMP formation and vascular response in contracting fast-twitch skeletal muscle.

NOS1 NOS3

3.06e-052193211015578
Pubmed

Renal cortical and medullary blood flow responses to L-NAME and ANG II in wild-type, nNOS null mutant, and eNOS null mutant mice.

NOS1 NOS3

3.06e-052193215961532
Pubmed

Supplementation of nitric oxide attenuates AβPP and BACE1 protein in cerebral microcirculation of eNOS-deficient mice.

NOS3 APP

3.06e-052193222886025
Pubmed

Contributions of endothelial and neuronal nitric oxide synthases to cerebrovascular responses to hyperoxia.

NOS1 NOS3

3.06e-052193214526232
Pubmed

MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3.

MCM3 MCM3AP

3.06e-052193211258703
Pubmed

A new allele of Gli3 and a new mutation, circletail (Crc), resulting from a single transgenic experiment.

GLI3 SCRIB

3.06e-052193212112872
Pubmed

Nitric oxide synthase polymorphisms and asthma phenotypes in Chinese children.

NOS1 NOS3

3.06e-052193216238787
Pubmed

Sustained nitric oxide (NO)-releasing compound reverses dysregulated NO signal transduction in priapism.

NOS1 NOS3

3.06e-052193224076963
Pubmed

Normal development of the ipsilateral retinocollicular pathway and its disruption in double endothelial and neuronal nitric oxide synthase gene knockout mice.

NOS1 NOS3

3.06e-052193211027405
Pubmed

Neuronal nitric oxide synthase plays a key role in CNS demyelination.

NOS1 NOS3

3.06e-052193217151270
Pubmed

Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism.

NOS1 NOS3

3.06e-052193218305236
Pubmed

Regulation of renin gene expression in kidneys of eNOS- and nNOS-deficient mice.

NOS1 NOS3

3.06e-052193210764216
Pubmed

Repetitive hyperbaric oxygen exposures enhance sensitivity to convulsion by upregulation of eNOS and nNOS.

NOS1 NOS3

3.06e-052193218342297
Pubmed

KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.

KMT2C KMT2D

3.06e-052193231924266
Pubmed

Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity.

NOS1 NOS3

3.06e-05219327488039
Pubmed

The NOS3 G894T (Glu298Asp) polymorphism is a risk factor for frontotemporal lobar degeneration.

NOS1 NOS3

3.06e-052193219087148
Pubmed

Genetic analysis of NOS isoforms using nNOS and eNOS knockout animals.

NOS1 NOS3

3.06e-05219329932431
Pubmed

Rapid cerebral ischemic preconditioning in mice deficient in endothelial and neuronal nitric oxide synthases.

NOS1 NOS3

3.06e-052193212677017
Pubmed

Experience-dependent plasticity acts via GluR1 and a novel neuronal nitric oxide synthase-dependent synaptic mechanism in adult cortex.

NOS1 NOS3

3.06e-052193221813683
Pubmed

Expression, localization, and regulation of NOS in human mast cell lines: effects on leukotriene production.

NOS1 NOS3

3.06e-052193215044250
Pubmed

Cutaneous neuronal nitric oxide is specifically decreased in postural tachycardia syndrome.

NOS1 NOS3

3.06e-052193217660395
Pubmed

Endothelial Nitric Oxide Synthase Is Present in Dendritic Spines of Neurons in Primary Cultures.

NOS1 NOS3

3.06e-052193228725180
Pubmed

Reproductive function in female mice lacking the gene for endothelial nitric oxide synthase.

NOS1 NOS3

3.06e-052193210534440
Pubmed

Analysis of nitric oxide synthase gene polymorphisms in neonatal respiratory distress syndrome among the Chinese Han population.

NOS1 NOS3

3.06e-052193224602444
Pubmed

Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and age-related hypertrophic cardiac remodeling in mice.

NOS1 NOS3

3.06e-052193212788381
Pubmed

Angiotensin II response in afferent arterioles of mice lacking either the endothelial or neuronal isoform of nitric oxide synthase.

NOS1 NOS3

3.06e-052193217959704
Pubmed

Effects of nitric oxide synthase gene knockout on neurotransmitter release in vivo.

NOS1 NOS3

3.06e-05219329692709
Pubmed

Myocardial and lymphocytic expression of eNOS and nNOS before and after heart transplantation: relationship to clinical status.

NOS1 NOS3

3.06e-052193223770231
Pubmed

Nitric oxide synthase 1 is partly compensating for nitric oxide synthase 3 deficiency in nitric oxide synthase 3 knock-out mice and is elevated in murine and human cirrhosis.

NOS1 NOS3

3.06e-052193215287858
Pubmed

Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance.

NOS1 NOS3

3.06e-052193210905473
Pubmed

Nitric oxide synthase gene polymorphisms in children with minimal change nephrotic syndrome.

NOS1 NOS3

3.06e-052193219371282
Pubmed

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.

KMT2C KMT2D

3.06e-052193228967912
Pubmed

Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms.

NOS1 NOS3

3.06e-052193211907582
Pubmed

Relative contribution of eNOS and nNOS to endothelium-dependent vasodilation in the mouse aorta.

NOS1 NOS3

3.06e-052193220624383
Pubmed

Neuronal NOS-cGMP-dependent ACh-induced relaxation in pial arterioles of endothelial NOS knockout mice.

NOS1 NOS3

3.06e-05219329486242
Pubmed

Refinement of the ipsilateral retinocollicular projection is disrupted in double endothelial and neuronal nitric oxide synthase gene knockout mice.

NOS1 NOS3

3.06e-052193210727738
Pubmed

Developmental changes in the response of murine cerebellar granule cells to nitric oxide.

NOS1 NOS3

3.06e-052193218406496
Pubmed

Diminished NO generation by injured endothelium and loss of macula densa nNOS may contribute to sustained acute kidney injury after ischemia-reperfusion.

NOS1 NOS3

3.06e-052193218971208
Pubmed

Does endothelial nitric oxide synthase gene variation play a role in the occurrence of hypertension in pregnancy?

NOS1 NOS3

3.06e-052193212908999
Pubmed

Role of nitric oxide synthase on brain GABA transaminase activity and GABA levels.

NOS1 NOS3

3.06e-052193231259693
Pubmed

Nitric oxide contributes to vascular smooth muscle relaxation in contracting fast-twitch muscles.

NOS1 NOS3

3.06e-052193211161004
Pubmed

Neuronal and endothelial nitric oxide synthase gene knockout mice.

NOS1 NOS3

3.06e-052193210559836
Pubmed

The cerebral metabolic consequences of nitric oxide synthase deficiency: glucose utilization in endothelial and neuronal nitric oxide synthase null mice.

NOS1 NOS3

3.06e-052193210027769
Pubmed

Priapism in a Fabry disease mouse model is associated with upregulated penile nNOS and eNOS expression.

NOS1 NOS3

3.06e-052193229110178
Pubmed

Carvedilol induces biased β1 adrenergic receptor-nitric oxide synthase 3-cyclic guanylyl monophosphate signalling to promote cardiac contractility.

NOS1 NOS3

3.06e-052193232956449
Pubmed

Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection.

NOS1 NOS3

3.06e-052193211904450
Pubmed

Modulation by NO of acetylcholine release in the ileum of wild-type and NOS gene knockout mice.

NOS1 NOS3

3.06e-052193212381527
Pubmed

Contribution of nNOS- and eNOS-derived NO to microvascular smooth muscle NO exposure.

NOS1 NOS3

3.06e-052193215033959
Pubmed

Infarct size and nitric oxide synthase in murine myocardium.

NOS1 NOS3

3.06e-052193210652188
Pubmed

Gastric stasis in neuronal nitric oxide synthase-deficient knockout mice.

NOS1 NOS3

3.06e-052193210982771
Pubmed

Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.

KMT2C KMT2D

3.06e-052193236601880
Pubmed

Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.

KMT2C KMT2D

3.06e-052193228483418
Pubmed

A missense mutation in the conserved C2B domain of otoferlin causes deafness in a new mouse model of DFNB9.

CDH23 OTOF

3.06e-052193217967520
Pubmed

Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation.

NOS1 NOS3

3.06e-052193226152695
Pubmed

Alternatively spliced neuronal nitric oxide synthase mediates penile erection.

NOS1 NOS3

3.06e-052193216488973
Pubmed

The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach.

NOS1 NOS3

3.06e-052193219095954
Pubmed

Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization.

MCM3 MCM3AP

3.06e-05219329712829
Pubmed

Neuronal nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo.

NOS1 NOS3

3.06e-052193218048451
Pubmed

The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.

KMT2C KMT2D

3.06e-052193234156443
Pubmed

Immunocytochemical distribution of nitric oxide synthase in the human seminal vesicle: a light and electron microscopical study.

NOS1 NOS3

3.06e-052193212802542
Pubmed

Oxygen seizure latency and peroxynitrite formation in mice lacking neuronal or endothelial nitric oxide synthases.

NOS1 NOS3

3.06e-052193212781920
Pubmed

Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS.

NOS1 NOS3

3.06e-05219327518615
Pubmed

Proteolytic degradation of nitric oxide synthase isoforms by calpain is modulated by the expression levels of HSP90.

NOS1 NOS3

3.06e-052193217970747
Pubmed

Physician-diagnosed asthma and acute chest syndrome: associations with NOS polymorphisms.

NOS1 NOS3

3.06e-052193217351927
Pubmed

Establishment of patterned thalamocortical connections does not require nitric oxide synthase.

NOS1 NOS3

3.06e-05219329786989
Pubmed

Endothelial nitric oxide synthase is predominantly involved in angiotensin II modulation of renal vascular resistance and norepinephrine release.

NOS1 NOS3

3.06e-052193218046021
Pubmed

Mammalian hemicentin 1 is assembled into tracks in the extracellular matrix of multiple tissues.

HMCN2 HMCN1

3.06e-052193232035013
Pubmed

Nitric oxide synthase gene polymorphisms in children with primary nocturnal enuresis: a preliminary study.

NOS1 NOS3

3.06e-052193217365914
Pubmed

NOS-I and -III gene variants are differentially associated with facets of suicidal behavior and aggression-related traits.

NOS1 NOS3

3.06e-052193217579350
Pubmed

Are myocardial eNOS and nNOS involved in the beta-adrenergic and muscarinic regulation of inotropy? A systematic investigation.

NOS1 NOS3

3.06e-052193216545353
Pubmed

Neuronal nitric oxide synthase in epidermis is involved in cutaneous circulatory response to mechanical stimulation.

NOS1 NOS3

3.06e-052193219940861
Pubmed

Displacement-encoded and manganese-enhanced cardiac MRI reveal that nNOS, not eNOS, plays a dominant role in modulating contraction and calcium influx in the mammalian heart.

NOS1 NOS3

3.06e-052193222058155
Pubmed

Neuronal nitric oxide synthase (NOS-I) knockout increases the survival rate of neural cells in the hippocampus independently of BDNF.

NOS1 NOS3

3.06e-052193217459722
Pubmed

Structures of human constitutive nitric oxide synthases.

NOS1 NOS3

3.06e-052193225286850
Pubmed

Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.

KMT2C KMT2D

3.06e-052193227280393
Pubmed

Protective role of peroxisome proliferator-activated receptor-β/δ against pulmonary oxygen toxicity mediated through changes in NOS expression levels.

NOS1 NOS3

3.06e-052193224624894
InteractionTOP3B interactions

TMEM94 CYTH1 INTS1 PEX6 CUL9 ANKLE1 UNC45A TTC3 GADD45A KMT2C URB1 MDN1 UBN1 TMCC2 MCM3AP NLRC5 MICAL3 PLEC HERC2 EPN3 PLXNA3 IARS1 POLG CEP192 APP KMT2D MROH6 NAPRT TNFAIP2 ULK2 PRRT4 EXOC4

4.62e-06147018632int:TOP3B
CytobandEnsembl 112 genes in cytogenetic band chr16q22

ENKD1 AP1G1 C16orf86 EXOC3L1 CARMIL2 SLC9A5 DERPC

1.35e-051831937chr16q22
Cytoband16q22.1

ENKD1 C16orf86 EXOC3L1 CARMIL2 SLC9A5

1.07e-04110193516q22.1
CytobandEnsembl 112 genes in cytogenetic band chr15q15

TUBGCP4 LCMT2 STARD9 STRC VPS18

4.11e-041471935chr15q15
Cytoband22q13.33

LMF2 MOV10L1 PANX2

5.54e-0438193322q13.33
GeneFamilyEF-hand domain containing|Plakins

PLEC DSP MACF1

1.60e-0581213939
GeneFamilySulfatases

GALNS SGSH ARSL

2.22e-04181213410
GeneFamilySPOUT methyltranferase domain containing

MRM1 TARBP1

1.21e-03812121294
GeneFamilyFibulins

HMCN2 HMCN1

1.21e-0381212556
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_4|356C / Donor, Lineage, Cell class and subclass (all cells)

PEX7 FANCE C16orf86 EXOC3L1 HEATR5A EFCAB3 WDFY4 KPTN

5.57e-0716219387d43d59531cbefe3ac94953b7faf7156b2a31441
ToppCellnormal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells|B_lymphocytes / Location, Cell class and cell subclass

CDH23 PTGDS NME8 LRRC26 PLCB4 MYO18A APP PLEKHG4B

1.04e-061761938d6e660df92a3d7dd5732171ee623763faf108476
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CA14 PTGDS NME8 PRDX3 MOV10L1 EPN3 DSP TOGARAM2

1.34e-061821938c4a7007c864a9455a7e7447e28ccd380878a6a0f
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CA14 PTGDS NME8 PRDX3 MOV10L1 EPN3 DSP TOGARAM2

1.34e-061821938c315d820ffad912c014ba5eac6f5fa6de1a94384
ToppCellfacs-Trachea-nan-3m-Epithelial|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BSPRY BPIFA1 LRRC26 EPN3 DSP TOGARAM2 PLCH2 ELF3

2.16e-0619419383701ca87c6dc9ccd7b4146e56371546174d26c36
ToppCellfacs-Trachea-nan-3m-Epithelial-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BSPRY BPIFA1 LRRC26 EPN3 DSP TOGARAM2 PLCH2 ELF3

2.16e-06194193865f9bf126be26114c2c3f4c46d48318986212a92
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ALPI EPN3 CACNA1F DSP SH2D3A HEATR5A IGFALS ELF3

2.61e-061991938d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCell10x5'v1-week_14-16-Endothelial-stroma-tip_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ACVRL1 FZD4 NID1 EXOC3L1 NOS3 APP OIT3 DCHS1

2.71e-06200193877ac1aa73c16a4f595ff01c6b4e171e0b8fed1e6
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Macroglial-Astrocyte|GW10 / Sample Type, Dataset, Time_group, and Cell type.

STARD9 GLI3 NFKBIB DDX54 NOS3 COL27A1 RGS20 SCRIB

2.71e-06200193898a994692440cb4f505b050276f0c8022c814a21
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Macroglial|GW10 / Sample Type, Dataset, Time_group, and Cell type.

STARD9 GLI3 NFKBIB DDX54 NOS3 COL27A1 RGS20 SCRIB

2.71e-062001938ef222dc4a205d670172dae74990bdb952ac92e5b
ToppCellLPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TMEM94 MDN1 LRRN2 TARBP1 VPS18 SGSH DCHS1

5.00e-06154193716fdafb5c64d2db321554f87129a962d113f1668
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LAYN GGT6 SH3RF2 EPN3 CHADL APP SCPEP1

6.17e-0615919371baf0eaf9684668146a63192e77eec6c3c7a37f8
ToppCellSevere-Lymphoid-NK-Proliferating_T|Severe / Condition, Lineage, Cell class and cell subclass

MCM3 BCKDHA ANKLE1 PTGDS NID1 P3H3 MYO18A

6.43e-061601937cb2276d9bd78508644420e9580d3c17b914224cb
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC1-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

BSPRY NME8 LRRC26 RAB11FIP1 WDFY4 CCDC17 SH3RF3

8.18e-061661937c8a7d94ed762e5e045ab5f74eef691ddc5f74993
ToppCellfacs-Lung-EPCAM-18m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCM3 CA14 ENKD1 KANSL2 NOS3 TARBP1 CARMIL2

9.55e-06170193712203d4410f38cc933d9f160b5fb76828df94119
ToppCellfacs-Lung-EPCAM-18m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCM3 CA14 ENKD1 KANSL2 NOS3 TARBP1 CARMIL2

9.55e-061701937f9decb3bf3bf6d4996b0ac27af768236e116aac5
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-5|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

STARD9 MICAL3 HEATR5A APP WDFY4 KYAT1 SCPEP1

9.92e-06171193723b3120706bb9c20b9214fe3760c6d7a84f1e749
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic-Paneth|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GGT6 BSPRY GDF1 LRRC26 SEZ6L2 IGFALS ELF3

1.15e-05175193724651f95540ea2c8f3720aa943cbdd15661ee3fa
ToppCellnormal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells|normal_Lymph_Node / Location, Cell class and cell subclass

PTGDS NME8 LRRC26 PLCB4 MYO18A APP PLEKHG4B

1.15e-05175193729fbdfe1d3bfcb063be2bced0128a33176c5b78f
ToppCell390C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|390C / Donor, Lineage, Cell class and subclass (all cells)

GGT6 BPIFA1 LRRC26 DSP ATP13A5 ELF3 TNFAIP2

1.29e-051781937fce60ce6b662f1bdaa3b4da43800c6c22fe89533
ToppCell390C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|390C / Donor, Lineage, Cell class and subclass (all cells)

GGT6 BPIFA1 LRRC26 DSP ATP13A5 ELF3 TNFAIP2

1.29e-051781937b19c906e067b07eadfd68934d9330b447e24c708
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENKD1 NRXN2 RTN4RL1 CNNM3 ANGPTL6 AP5B1 SH3RF3

1.34e-051791937b44e2d53b82c3c141bfc6539054b19708200a0d9
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-OMD+_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PTGDS HMCN2 SH3RF2 SLC22A14 MOV10L1 NOS1 HMCN1

1.34e-0517919378c9ed247e1c4d655b81ce2f24a9936a7cade718a
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AVP CDH23 PTGDS NME8 LRRC26 CARMIL2 WDFY4

1.38e-0518019376a2366d76276452141db1bd93013a9503525f574
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SH3RF2 ALPI CACNA1F DSP SH2D3A HEATR5A PLEKHG4B

1.43e-051811937b45b11428d13950369347e051d4d517efb2bd4fd
ToppCellCOVID-19_Mild-Neu_3|World / 5 Neutrophil clusters in COVID-19 patients

GLI3 CARMIL2 PCDHGB3 TOGARAM2 HMCN1 HSD17B14

1.54e-0512219362aa9cfadab70312882ae679e3788fc7ab996c0f3
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NID1 PLCB4 FLRT1 NOS3 P3H3 PCDHGA3 PRRT4

1.60e-051841937f506d0ee48f39d6f59f19554217dfdf0987cc405
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NID1 PLCB4 FLRT1 NOS3 P3H3 PCDHGA3 PRRT4

1.60e-0518419378bcb1c4bc8ffef74338cdade926a94711de93c64
ToppCellHealthy_donor-pDC|Healthy_donor / disease group, cell group and cell class (v2)

BSPRY PTGDS LRRC26 PLCB4 APP WDFY4 PLEKHG4B

1.65e-0518519377fbb55cbdb39bdecb6063c8ba9776ab06c2666e8
ToppCellHealthy_donor-pDC|World / disease group, cell group and cell class (v2)

BSPRY PTGDS LRRC26 PLCB4 APP WDFY4 PLEKHG4B

1.77e-051871937aa2cc54487d3c5045ac0c93560944c5a55878e27
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BPIFA1 TTC3 NRXN2 RTN4RL1 FAM131A PANX2 PLCH2

1.77e-051871937e04a84989d624378141042768383b9c846901f2d
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BPIFA1 TTC3 NRXN2 RTN4RL1 FAM131A PANX2 PLCH2

1.77e-05187193724cc03c748e15f7ef0e6509ca5a6ca583fb9c573
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BPIFA1 TTC3 NRXN2 RTN4RL1 FAM131A PANX2 PLCH2

1.77e-0518719372f153b203fe79f206319603cf94d3a03ab49a05d
ToppCellfacs-Trachea-3m-Epithelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BSPRY BPIFA1 LRRC26 DSP RAB11FIP1 PLCH2 ELF3

1.90e-051891937f8959cc2c14899c8dfeb1b5e51e187537df2f03e
ToppCellBAL-Severe-Myeloid-pDC-pDC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

BSPRY PTGDS NME8 LRRC26 RAB11FIP1 APP WDFY4

2.10e-051921937d9ff2293358c8b031ba212021012e058014ff472
ToppCellSevere_COVID-19-Myeloid-pDC|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

BSPRY PTGDS NME8 LRRC26 RAB11FIP1 APP WDFY4

2.10e-051921937f79424c643a375dfe4579eff7ac1ba191e28a283
ToppCellBAL-Severe-Myeloid-pDC-pDC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

BSPRY PTGDS NME8 LRRC26 RAB11FIP1 APP WDFY4

2.10e-0519219372e8611d65090e39f1a6e74c972288e7b68376d15
ToppCellLPS_only-Endothelial-Endothelial-Vein|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ACVRL1 FZD4 EXOC3L1 PLCB4 NOS3 HMCN1 SH3RF3

2.10e-05192193752acaecd3703166f5ce3b328aff7c82bd142fee4
ToppCellBAL-Severe-Myeloid-pDC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

BSPRY PTGDS NME8 LRRC26 RAB11FIP1 APP WDFY4

2.10e-05192193743569726df281eebe57499e0993b9fd9d36118c2
ToppCell15-Trachea-Endothelial-Endothelial|Trachea / Age, Tissue, Lineage and Cell class

ACVRL1 PTGDS NID1 EXOC3L1 NOS1 OIT3 HMCN1

2.17e-0519319376ea0444fc3dc156997129387184e6418947f4b12
ToppCell15-Trachea-Endothelial|Trachea / Age, Tissue, Lineage and Cell class

ACVRL1 PTGDS NID1 EXOC3L1 NOS1 OIT3 HMCN1

2.17e-051931937b1ebf8df2d55e2938e5a495ea68b80c4ac216dc0
ToppCellVE-pDC-|VE / Condition, Cell_class and T cell subcluster

CDH23 PTGDS NME8 LRRC26 PLCB4 APP WDFY4

2.17e-051931937583724de588fcde3aeda056138c522dc0225a387
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-DC-DC3-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

BSPRY PTGDS NME8 LRRC26 DSP RAB11FIP1 WDFY4

2.17e-0519319375a4accf3af236ff285942163c45277a80263f421
ToppCellVE-pDC|VE / Condition, Cell_class and T cell subcluster

CDH23 PTGDS NME8 LRRC26 PLCB4 APP WDFY4

2.17e-051931937bb759dc9ef0ec41d655002f59021d62d62d44289
ToppCell3'-Child04-06-SmallIntestine-Mesenchymal-stromal_related-FDC|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PTGDS PLCB4 GP1BA COL27A1 IGFALS HMCN1 TNFAIP2

2.24e-051941937f9fbb043411546d8c9e0321a64165d411f44aeb7
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC3|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

BSPRY CDH23 PTGDS NME8 LRRC26 RAB11FIP1 WDFY4

2.24e-0519419373f9e4a8e5699bc379e8a0d337e0daef09632e71c
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC3-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

BSPRY CDH23 PTGDS NME8 LRRC26 RAB11FIP1 WDFY4

2.24e-0519419375250736b608001fb73aa74dee8cb8465a1d2f372
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4|TCGA-Prostate / Sample_Type by Project: Shred V9

LAYN TMEM200B GLI3 TMCC2 COL27A1 KIAA1614 TNFAIP2

2.32e-0519519375562665dd3beb70e2358aa32611a337bef5731c1
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-pDC-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

BSPRY CDH23 PTGDS NME8 LRRC26 RAB11FIP1 WDFY4

2.32e-05195193706051de72b5c1e0d483a28b14dabd247dfca0ed9
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-DC-DC3|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

BSPRY PTGDS NME8 LRRC26 DSP RAB11FIP1 WDFY4

2.32e-051951937de60fa0c69c835f0b1d6d2dba1a1acd73246b001
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-pDC|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

BSPRY CDH23 PTGDS NME8 LRRC26 RAB11FIP1 WDFY4

2.32e-0519519373aa44633c72658545aa2b35bf9d532c62f36a451
ToppCell3'-Child04-06-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SH3RF2 PLCB4 DSP APP SEZ6L2 ELF3 FGGY

2.32e-051951937b67d4f34cae729c18275486d3b20c9dd7d5cbe79
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYTH1 CA14 PTGDS DNAJB2 SHISA4 SEZ6L2 SLC4A2

2.47e-0519719377b12f9d4ad1e84df58e86591a491c84d4f36eac5
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SH3RF2 ALPI CACNA1F DSP SH2D3A HEATR5A ELF3

2.56e-051981937b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCellControl_saline|World / Treatment groups by lineage, cell group, cell type

ACVRL1 PLCB4 PLEC DSP APP HMCN1 MACF1

2.64e-05199193711c9c1779caceb725ecccf3f23b7d4e6dbd1af64
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GGT6 BSPRY LRRC26 EPN3 DSP ATP13A5 ELF3

2.64e-051991937fbd39d34636137d1b877dd8815d58f124990136b
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-tip_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ACVRL1 FZD4 NID1 EXOC3L1 NOS3 APP OIT3

2.64e-0519919371c69395c9305b6ecb0a826d46c8e8ec95795ad6d
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SH3RF2 ALPI CACNA1F DSP SH2D3A HEATR5A ELF3

2.64e-051991937a270630626df614f8605abddb7dee7c4d74f6149
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GGT6 BSPRY LRRC26 EPN3 DSP ATP13A5 ELF3

2.64e-0519919376977f939ddbc47d4921f36c0a61a205259fe1284
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ACVRL1 FZD4 NID1 EXOC3L1 NOS3 DSP HMCN1

2.64e-0519919370602e2b2aa56d106da63bd342a38bef437b4d496
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GGT6 BSPRY LRRC26 EPN3 DSP ATP13A5 ELF3

2.73e-0520019378c4c396e99be6131a8fa60d86214d561031b12bf
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Macroglial-Astrocyte|GW09 / Sample Type, Dataset, Time_group, and Cell type.

CDH23 ENKD1 C16orf86 NOS3 HYAL1 FGGY

3.64e-05142193685e573616e54d41391b4ad8c3d38e4ca92112673
ToppCellLPS-antiTNF-Endothelial-Epi-like-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ENKD1 ZSWIM9 STRC CACNA1F KIF27 SH2D3A

4.94e-0515019369cb3332924bd67c966873343c14445e30d3f384f
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_dendritic-liver_dendritic_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PEX6 NME8 C16orf86 EXOC3L1 SHISA4 ANGPTL6

5.72e-051541936acfbde0fbc09fd69af62a81f8f63e14e36dd1ae0
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BSPRY KANSL2 CDC42BPG KIAA1614 IGFALS ARSL

6.59e-051581936ab707bfe782c667b252b488ad1d7efd49cf0a899
ToppCelldroplet-Limb_Muscle-nan-18m-Myeloid-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANKRD13B LAYN CACNA1F KIF27 COL27A1 SLC11A1

7.57e-05162193671d7849108a1b59beff40e46000172c45a2f5439
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-LTi-like_NCR-_ILC3|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANKRD13B NFKBIB NLRC3 GP1BA CARMIL2 IPO13

8.10e-05164193674bf6080abd9191e3db8ee892fce84f1dcc4b775
ToppCellFrontal_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Abcc9_(Mural.Rgs5Acta2.Abcc9)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

TMEM200B HMCN2 C16orf86 ATP13A5 EFCAB3

8.20e-0510219358c4d9483ff983538593f4e17f4a74a93cdda59c4
ToppCellFrontal_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Abcc9_(Mural.Rgs5Acta2.Abcc9)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

TMEM200B HMCN2 C16orf86 ATP13A5 EFCAB3

8.20e-05102193572ce247dad7404e6b9c971b5c29d3c6846da5efc
ToppCellFrontal_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

TMEM200B HMCN2 C16orf86 ATP13A5 EFCAB3

8.20e-0510219355feedce6d26a578c4aaba4e4824b3d0c3f3806bc
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Hematologic-red_blood_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIDD1 GADD45A TMEM200B TMCC2 PLCB4 DNAH17

8.37e-05165193662dd54dfbec7f43a41546a1fec719545c2608a36
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|356C / Donor, Lineage, Cell class and subclass (all cells)

INTS1 STARD9 NLRC3 CACNA1F AMT ULK2

8.66e-051661936c4f7ea1cad962b1d6ad77423d15978b68a0d6f1d
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L6_SST_NPY_(Sst_Chodl)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LAYN KCTD4 OTOF NOS1 DSP PLEKHG4B

8.95e-051671936de3ce3cf2815b0ad97755b71bb4505c3a2d1daa1
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PEX6 CARNS1 SH2D3A RAB11FIP1 NAPRT ELF3

8.95e-051671936d1a13d6ada572d8ddb2da95e6e122d2b705fad7f
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FREM1 STARD9 GLI3 FAM131A KIAA1614 MACF1

9.55e-05169193616c52a0f6d96ecc1832922fce9b39691849f0d73
ToppCellAdult-Endothelial-endothelial_cell_of_vein-D175|Adult / Lineage, Cell type, age group and donor

FZD4 MOV10L1 PLCB4 NOS1 NOS3 SH3RF3

9.55e-051691936e1f0298236e4a1c59077c14f0dd29a78fac12648
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KCTD4 FLRT1 P3H3 COL27A1 CHADL UNC80

9.55e-05169193658e22f9119240664515fe91ca53812611a8f17d6
ToppCell10x5'-blood-Myeloid_Dendritic-pDC|blood / Manually curated celltypes from each tissue

PTGDS LRRC26 PLCB4 APP WDFY4 PLEKHG4B

9.87e-05170193659cb1262ff319349d42b11afbec2a9035b7b79f2
ToppCellCOVID_vent-Lymphocytic-Dendritic-pDC|COVID_vent / Disease condition, Lineage, Cell class and subclass

PTGDS LRRC26 TARBP1 APP WDFY4 PLEKHG4B

1.02e-041711936779c951d274ecbd1d546ac425d6c8e718623be5a
ToppCellCOVID_vent-Lymphocytic-Dendritic|COVID_vent / Disease condition, Lineage, Cell class and subclass

PTGDS LRRC26 TARBP1 APP WDFY4 PLEKHG4B

1.02e-041711936debbb071d260639b16269c94d172766908325c58
ToppCell356C-Lymphocytic-ILC-ILC-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

BCKDHA LCMT2 FANCE AP1G1 AK4 DNAH17

1.02e-0417119363d26ef58fe5231373d7df9ac79d225546918cf82
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

PLCB4 CARNS1 NOS1 NOS3 SHROOM1 HMCN1

1.02e-0417119361597459c971d6befa991d59dc66b41b6a522f797
ToppCell390C-Myeloid-Dendritic-pDC|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

BSPRY PTGDS NME8 CARMIL2 TOGARAM2 SH3RF3

1.05e-0417219363f894c74916d49a995b2d4651ca1c6733c14ce9c
ToppCell356C-Lymphocytic-ILC-ILC-2|ILC / Donor, Lineage, Cell class and subclass (all cells)

LCMT2 FANCE URB1 AP1G1 AK4 DNAH17

1.05e-0417219364977e1f4deae781750e27a8054deccd336cfb74a
ToppCellmild_COVID-19-pDC|World / disease group, cell group and cell class (v2)

BSPRY LRRC26 PLCB4 APP PLEKHG4B HMCN1

1.05e-041721936dab2f1a05c7df58d9387b13271b3f1f1583f9ac3
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BPIFA1 SH3RF2 CDC42BPG DSP PANX2 ELF3

1.12e-041741936207aa0118633cbe9a65839bbb1bb3ba9f8118ad2
ToppCellmetastatic_Brain-Myeloid_cells-CD141+_DCs|Myeloid_cells / Location, Cell class and cell subclass

SH3RF2 NLRC5 TAP1 BEND5 WDFY4 MAP4K1

1.12e-0417419365ec8a48a390379d6c422120dce46437a77da67cc
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Proximal_progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SH3RF2 STRC DSP SH2D3A RAB11FIP1 ELF3

1.16e-0417519366759d200a133034756de9cdf2d5daceca927aac9
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Proximal_secretory_3|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

BSPRY BPIFA1 SH3RF2 LRRC26 DSP SH2D3A

1.19e-0417619368d9d0fb46c418b2067be58aec822e8c2b1561461
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-early_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCTD4 CA14 MICAL3 COL27A1 HMCN1 FGGY

1.19e-0417619367292e014b8f697f0c2e9f47c48333de95cb44a69
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-early_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCTD4 CA14 MICAL3 COL27A1 HMCN1 FGGY

1.19e-04176193688ca2f83d8301633232735f39b0683efe49d0b86
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCM3 FZD4 LRRN2 PLXNA3 TSPY26P RAB11FIP1

1.23e-04177193630f82b04e48940bfcaf2c22677efe6d57ae3f1a7
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AVP PTGDS NME8 LRRC26 TARBP1 WDFY4

1.31e-041791936c9f45cfea0ceb0cdc31bcfd123aeab69aeb35c35
ToppCelldroplet-Lung-LUNG-30m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BPIFA1 PLCB4 FLRT1 NOS3 PCDHGA3 PRRT4

1.31e-041791936a09647750eba9d93c5efc1db3b555fefb5eec7b5
ToppCellBAL-Mild-cDC_4|Mild / Compartment, Disease Groups and Clusters

CUL9 STARD9 RNF44 CEP192 DCHS1 IPO13

1.31e-04179193668511e87b12b8253de7771e5ccfc5869248b8450
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AVP PTGDS NME8 LRRC26 CARMIL2 WDFY4

1.31e-0417919364808469096cd6bec2bdfcf4fc55aa324757600c3
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AVP PTGDS NME8 LRRC26 CARMIL2 WDFY4

1.31e-0417919364d55718c6afd8a038d93cc77b9b08171dab9976f
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

LRRN2 VPS18 MYO18A DNAH17

1.33e-0460193428415d543aaccc74d19e1bb92b7e6fa94f97f8f2
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

LRRN2 VPS18 MYO18A DNAH17

1.33e-0460193471eba0fbef11cfc2b1c525d5f051530750e4fce9
ToppCelldroplet-Liver-Npc-21m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCOA3 NRXN2 NID1 EXOC3L1 NOS3 OIT3

1.43e-041821936dc55de945c6f78f32eb3a1b3520835eb8417e068
DiseaseSarcosine measurement

PEX6 PCDHGB3 PCDHGA3 PCDHGA2

1.26e-05231874EFO_0021668
DiseaseKleefstra syndrome 2 (implicated_via_orthology)

KMT2C KMT2D

4.00e-0521872DOID:0080598 (implicated_via_orthology)
DiseaseIntestinal Perforation

NOS1 NOS3

1.19e-0431872C0021845
Disease4-acetamidobutanoate measurement

MOV10L1 PANX2 HDAC10

1.32e-04161873EFO_0021003
DiseaseMalignant neoplasm of breast

NCOA3 TTC3 NME8 LMF2 OTOF NLRC5 UMPS EXOC3L1 HERC2 NOS3 SH2D3A FAM131A JAKMIP3 PANX2 PCDH20 KMT2D MACF1 CPSF3

1.76e-04107418718C0006142
Diseaseportal hypertension (implicated_via_orthology)

AVP NOS1 NOS3

2.25e-04191873DOID:10762 (implicated_via_orthology)
DiseaseAlzheimer disease type 1

NOS3 APP

2.38e-0441872cv:C1863052
DiseaseALZHEIMER DISEASE, FAMILIAL, 1

NOS3 APP

2.38e-0441872104300
DiseaseCruveilhier-Baumgarten Syndrome

AVP NOS3

2.38e-0441872C0010398
Diseasemean platelet volume

MCM3 ACVRL1 GADD45A UBN1 AP1B1 AP2B1 TMCC2 NID1 UMPS PLEC MVP NOS3 GP1BA PCDHGB3 PCDHGA3 PCDHGA2 ULK2

2.85e-04102018717EFO_0004584
DiseasePartial Fetal Alcohol Syndrome

BPIFA1 NOS1

3.95e-0451872C3661483
DiseaseAlcohol Related Neurodevelopmental Disorder

BPIFA1 NOS1

3.95e-0451872C0814154
DiseasePortal Hypertension

AVP NOS3

3.95e-0451872C0020541
Diseasemental development measurement

PCDHGB3 PCDHGA3 PCDHGA2

5.20e-04251873EFO_0008230
Disease2,3-dihydroxy-5-methylthio-4-pentenoate (DMTPA) measurement

PEX6 CARNS1

5.89e-0461872EFO_0800111
DiseaseAlcohol Related Birth Defect

BPIFA1 NOS1

5.89e-0461872C3146244
DiseaseEarly-onset autosomal dominant Alzheimer disease

NOS3 APP

8.22e-0471872cv:CN043596
DiseasePolysyndactyly

FZD4 GLI3

8.22e-0471872C0265553
Diseasebeta-secretase 1 measurement

CDH23 RGS20

1.09e-0381872EFO_0009179
Diseaseperoxisomal biogenesis disorder (implicated_via_orthology)

PEX6 PEX7

1.09e-0381872DOID:0080377 (implicated_via_orthology)
DiseaseAlzheimer disease

NOS3 APP

1.09e-0381872cv:C0002395
Diseaseperoxisomal biogenesis disorder (is_implicated_in)

PEX6 PEX7

1.09e-0381872DOID:0080377 (is_implicated_in)
Diseaseplatelet glycoprotein ib alpha chain measurement

AK4 GP1BA

1.74e-03101872EFO_0020645
DiseaseCleft Palate

INTS1 FZD4 PLCB4 NOS3

1.78e-03811874C0008925
DiseaseX-11315 measurement

MROH6 NAPRT

2.12e-03111872EFO_0021223
Diseasecysteine-glutathione disulfide measurement

IARS1 SH3RF3

2.12e-03111872EFO_0021001
Diseasecognitive decline measurement, memory performance, language measurement

GLI3 TNFAIP2

2.12e-03111872EFO_0004874, EFO_0007710, EFO_0007797
DiseaseDiabetes, Autoimmune

NOS1 NOS3 SLC11A1

2.74e-03441873C0205734
DiseaseBrittle diabetes

NOS1 NOS3 SLC11A1

2.74e-03441873C0342302
DiseaseDiabetes Mellitus, Sudden-Onset

NOS1 NOS3 SLC11A1

2.74e-03441873C4554117
DiseaseDiabetes Mellitus, Ketosis-Prone

NOS1 NOS3 SLC11A1

2.74e-03441873C3837958
DiseaseSeizures

NOS1 SGSH POLG APP KPTN MACF1

2.75e-032181876C0036572
Diseaseosteoarthritis, hip

PLEC HERC2 COL27A1 CHADL

2.83e-03921874EFO_1000786
DiseaseDiabetes Mellitus, Insulin-Dependent

NOS1 NOS3 SLC11A1

2.92e-03451873C0011854
Diseasecardiomyopathy (biomarker_via_orthology)

NOS1 NOS3

2.98e-03131872DOID:0050700 (biomarker_via_orthology)
DiseaseFetal Alcohol Spectrum Disorders

BPIFA1 NOS1

2.98e-03131872C2985290
DiseaseMale sterility

NOS3 POLG KMT2D

3.51e-03481873C0917731
DiseaseMale infertility

NOS3 POLG KMT2D

3.51e-03481873C0021364
DiseaseSubfertility, Male

NOS3 POLG KMT2D

3.51e-03481873C0848676
DiseasePeroxisome biogenesis disorders

PEX6 PEX7

3.97e-03151872C1832200
DiseaseWeight Gain

NID1 APP VPS13D FGGY

4.10e-031021874C0043094
DiseaseNonsyndromic Hearing Loss and Deafness, Autosomal Recessive

CDH23 OTOF STRC

4.17e-03511873cv:CN043650
Diseaseimmature platelet count

AP2B1 TMCC2 AK4 PLEC

4.69e-031061874EFO_0803544
DiseaseMetastatic melanoma

TTBK1 MAP4K1 ULK2

4.90e-03541873C0278883
DiseaseTactile Amnesia

AVP APP

5.10e-03171872C0750906
DiseaseAmnestic State

AVP APP

5.10e-03171872C0750907
DiseaseDissociative Amnesia

AVP APP

5.10e-03171872C0236795
DiseaseHysterical amnesia

AVP APP

5.10e-03171872C0233750
DiseaseTemporary Amnesia

AVP APP

5.10e-03171872C0233796
DiseaseAmnesia

AVP APP

5.10e-03171872C0002622
DiseaseGlobal Amnesia

AVP APP

5.10e-03171872C0262497
DiseaseFetal Alcohol Syndrome

BPIFA1 NOS1

5.10e-03171872C0015923
DiseaseColorectal Carcinoma

GALNS LRRC47 FZD4 KMT2C GLI3 MCM3AP NID1 UMPS VPS18 DCHS1 EXOC4

5.36e-0370218711C0009402
Diseasenephrotic syndrome (is_marker_for)

GP1BA IGFALS

5.72e-03181872DOID:1184 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
LAALLRQGEEAIGNP

URB2

1326

Q14146
RGEQVTLGLPLELLE

nan

86

Q8N976
VLLLRLGSGPAIDLE

BEND5

241

Q7L4P6
LLGLEVAGLRQQFPD

EXOC3L1

661

Q86VI1
PLALQGRDIIGLAET

DDX47

56

Q9H0S4
IGDLLRQIPLAVLFG

SLC4A2

1106

P04920
PLGPQDLRLLGDASL

CCDC17

321

Q96LX7
LILLNGTIQGDPLDL

ATP13A5

536

Q4VNC0
VEQLQALLPLAGELG

C16orf86

231

Q6ZW13
SQLLRELVLLPAGAD

ENKD1

296

Q9H0I2
GLELLLSQGADPALR

ANKLE1

91

Q8NAG6
KGLLPAEELIRSNLG

C8orf86

6

Q6ZUL3
IPSQGDLLGDLLNLD

AP2B1

621

P63010
VIDGQDLLPLLLGTA

ARSL

431

P51690
LLALGLPRDGKELAE

LINC00696

116

Q6ZRV3
AEESDQLLIRPLGAG

CPSF3

6

Q9UKF6
GLIPVFALGRAQELL

CPSF3

236

Q9UKF6
RALEVPTDGNAGLLA

APP

16

P05067
PDALRALLDGLALNT

CARMIL2

476

Q6F5E8
PDALDLGILGEALTQ

EPN3

471

Q9H201
GLLRLNLLEEALVPG

CARNS1

766

A5YM72
NRVAGLLEDTFPGLL

IGFALS

276

P35858
DGQLALILGPVLALL

ACVRL1

116

P37023
ALEELRLVFGPLGDQ

ELF3

106

P78545
VIPAQGDLLGDLLNL

AP1B1

621

Q10567
GVLTLNGLLDRENPL

CDH23

291

Q9H251
EAFGLGDLPNLLGLV

ADAMTS14

226

Q8WXS8
LAPLGALEFLRLNGN

RTN4RL1

241

Q86UN2
DLGLEPLALAEQGVR

PCDHGA2

51

Q9Y5H1
EAGLALPRLEEALQG

P3H3

231

Q8IVL6
LLNEAAPLALGAGLV

CDC42BPG

1251

Q6DT37
ARPDLVGQEFLLLAG

LRRC3C

191

A6NJW4
EGAVRGLEALLADPQ

NOL11

126

Q9H8H0
LLDLLGDINLTGAPA

AP1G1

656

O43747
LAGQDRELLLAAAQP

ANKRD13B

211

Q86YJ7
LVLGNKRDLPGALDE

ARL8A

126

Q96BM9
ALQAGLRSLQDLGPE

CACNA1F

1616

O60840
ALGLAPDLNLLLVGA

DCHS1

2926

Q96JQ0
LPAGVLIGSLAEDLR

PCDH20

76

Q8N6Y1
VEEAAGGPQLALALL

EXOSC4

176

Q9NPD3
GRLAAELQALLPEPL

ESPNL

531

Q6ZVH7
LAKENGRLPALEGTL

MICAL3

1561

Q7RTP6
VLDRLNALLEPGGVL

MDN1

2251

Q9NU22
RLALLGDALEPGVAL

GLI3

956

P10071
GLTDGPARLLNLDLD

KMT2C

4411

Q8NEZ4
RNGDLLVLEVPGLAE

MOV10L1

561

Q9BXT6
LAVAVPARALLILDG

NLRC3

206

Q7RTR2
LGRLQDLLLGPKADE

INTS1

951

Q8N201
PLIDTERNLGLLLGL

HERC2

1301

O95714
LLDGFPRTLGQAEAL

AK4

86

P27144
ARGLDPDGLLLLDVV

HMCN2

4496

Q8NDA2
LLSASDLDLRGGQPV

LAYN

26

Q6UX15
LRVLDLSGNALEALP

LRRC47

101

Q8N1G4
LDHILGLLQEELRGP

LMAN1L

426

Q9HAT1
GDRPGLIAILALAVL

LRRN2

626

O75325
LVSRLLAQGPELGLE

ASPDH

21

A6ND91
PIAEENLARGLLDLG

MCM3AP

1286

O60318
AAALLQALGLRDEPQ

GDF1

36

P27539
ALAGLLRLGDQTEPV

KIAA1614

826

Q5VZ46
DLAARGLDIPLLDNV

DDX54

396

Q8TDD1
VLELLLRAGANPAAR

NFKBIB

256

Q15653
LLALGNVISALGDPR

KIF27

271

Q86VH2
GLLLAQALGVPADED

PLXNA3

301

P51805
LNRGLEDQLLLPGSD

KPTN

291

Q9Y664
NIPRELVGGLELFLT

OIT3

276

Q8WWZ8
LALGLVPGDRLVEIN

MYO18A

266

Q92614
AAELGLVLALRPAGE

PEX6

31

Q13608
GTLLILDPDEAGLRL

PEX7

46

O00628
RILVQDDLGLPNGLT

NID1

1101

P14543
RLAQGAVGLLSPDLL

FREM1

1516

Q5H8C1
LASVDLNGRLPDLIA

NRXN2

1066

Q9P2S2
INDGGDLPEELLRNL

CYTH1

221

Q15438
GELLLPEGFRENQLL

KCTD4

96

Q8WVF5
LQALLSALRDGGPEK

JAKMIP3

116

Q5VZ66
VARPEQGALLRGLFL

SLC11A1

216

P49279
LGPLDERGAAQLSIL

TUBGCP4

601

Q9UGJ1
LLPGALRAGIEAVLL

GDPGP1

181

Q6ZNW5
LGALLGTEALRAEEP

AMH

16

P03971
GLVNLSDPAALERLL

AMH

326

P03971
LLPALLGALGEGDAR

MROH6

441

A6NGR9
LLRLEAALADGVPVA

AP5B1

841

Q2VPB7
AIPEELDRGSLVGNL

PCDHGB3

36

Q9Y5G1
GLLLRALQPLEEGED

MVP

331

Q14764
AARLAQLLPGLGALQ

NLRC5

1021

Q86WI3
ALPLQGLEDLAADRI

MACF1

4776

Q9UPN3
LGDPNVELLDRGQVL

HMCN1

1496

Q96RW7
GDIILAVNGRPLVDL

NOS1

61

P29475
VLALGLQPGDIVLDL

NSUN4

166

Q96CB9
RLSAQAEGLQLLPGL

NOS3

736

P29474
GLRLQLSLGVIPAEE

ALPI

11

P09923
GNIANDLGLEPRELA

PCDHGA3

46

Q9Y5H0
RGDINILLIGDPSVA

MCM3

336

P25205
QGLDLAPILRAAGLL

DERPC

271

P0CG12
QLLLLLGPARGFGDE

FZD4

26

Q9ULV1
RAIDGLNLLPTLLQG

GALNS

361

P34059
GPLLQVEGLSDLRLE

EXOC4

166

Q96A65
QLAGILARVLNGEAP

HDAC10

616

Q969S8
PDANIREVGLEGALL

HEATR5A

1116

Q86XA9
GLLRGPAQLGVVLDL

BSPRY

346

Q5W0U4
SGGLLGILENLPLLD

BPIFA1

61

Q9NP55
FLLLALLLPGGDNAD

CD1C

6

P29017
LINDLLASGEIPGLF

DNAH17

2871

Q9UFH2
EAARDLGLLPGIAVA

FGGY

241

Q96C11
NGVPDDLALGLELSR

DNAJB2

206

P25686
GRLAELLLLETDAGP

GADD45A

96

P24522
AGPELLALLEAALRS

GGT6

316

Q6P531
GLVRPGTALELLEAQ

DSP

2281

P15924
LELAAALRDLGQPAA

F8A1;

146

P23610
EDGLLGSPARLASQL

FAM131A

261

Q6UXB0
GSPARLASQLLGDEL

FAM131A

266

Q6UXB0
EPAAALALLGERVLN

ANGPTL6

131

Q8NI99
GAPEDVDILQRLGLS

COL27A1

41

Q8IZC6
GPILELLAAAGRDVA

IFNL4

106

K9M1U5
LPLGALRGLGELQEL

GP1BA

131

P07359
LTELPAGLLNGLENL

GP1BA

176

P07359
ELDPIRLALLGKSGL

CEP192

1161

Q8TEP8
GRALEQELPGAVFIL

HSD17B14

46

Q9BPX1
LTGPEGLLAKERENL

KANSL2

241

Q9H9L4
VGGPSAELLLDLERV

CUL9

956

Q8IWT3
GPLSLRGALSLEDQA

HYAL1

396

Q12794
ARLLLQALQAGPEGA

FANCE

26

Q9HB96
LPRGLFDDLGNLAQL

FLRT1

281

Q9NZU1
GLEVLDNALLALQGP

AMT

171

P48728
TGALEGLPALLELQL

CHADL

586

Q6NUI6
VAQAGPLVDGELLRL

GRIPAP1

126

Q4V328
AERPQGLAVLGILIE

CA14

151

Q9ULX7
DLAGNPGILLFEILS

EFCAB3

131

Q8N7B9
CLLLLFLPEGEDGLR

SLC22A14

451

Q9Y267
AADLGVGPLIVLRAL

SLC17A5

156

Q9NRA2
LAAAADALLRGLLDP

SBK2

296

P0C263
ALALELLERAGGSQP

SLC39A13

21

Q96H72
PVDGQGRCLALLELL

IPO13

156

O94829
GDLLAAFELLQIGPA

OTOF

1086

Q9HC10
PEIGGLGSLLELNLA

PIDD1

211

Q9HB75
GLSQAALLLLRQPGA

BCKDHA

16

P12694
LRELILPGAQDDKAG

PANX2

21

Q96RD6
IPLGISLGIDQDRAA

SLC16A6

316

O15403
QPGLNRGLILDLLDK

MAP4K1

276

Q92918
LVQPAAGGRALLLDQ

POLG

241

A0A3B3IS91
LVLGEGLCDFRLQAP

RAB11FIP1

1021

Q6WKZ4
LIGQRILPLDGLQAG

PLCB4

781

Q15147
GAPGNLDALLEELRE

TMCC2

511

O75069
LDLGLGELLLGAPAA

TMEM200B

261

Q69YZ2
LLNNEEPSQLLRGLG

TOGARAM2

56

Q6ZUX3
EAPRLGLDTAQGLEL

LMF2

66

Q9BU23
EELPGRLSLLLGAAL

RGS20

121

O76081
LLPLLLGLNAGAVID

SCPEP1

16

Q9HB40
GGEELSRLLLDDLVP

MRM1

31

Q6IN84
GELLGQEIDPLRNVL

KYAT1

81

Q16773
DSLGPLLLQALDGFL

NCOA3

111

Q9Y6Q9
LALLGVLGDLQAAPE

PTGDS

11

P41222
RILDPEGLALGAVIA

FTSJ3

661

Q8IY81
GLLDGLIPLAEVRAA

SHROOM1

571

Q2M3G4
ALLVLGAPLVLAGED

SHISA4

16

Q96DD7
GLVAPRVQAGLLDFL

SLC9A5

161

Q14940
AALGLALPGLALFRE

TAP1

101

Q03518
LALRGLFIIDPNGVI

PRDX3

181

P30048
GVLLLENPKGDNRLD

IARS1

1096

P41252
PSRQLEGGNLALAIL

SEZ6L2

836

Q6UXD5
RLEELPAELGGLVLL

SCRIB

231

Q14160
LDGDLAASRLGLSPL

STARD9

606

Q9P2P6
RPRNALLLLADDGGF

SGSH

21

P51688
VRGLGALLPTLAVDE

URB1

1181

O60287
GIPDLALSALLRGQI

STRC

1666

Q7RTU9
PGGAKELLLRDLDQL

ATF6B

481

Q99941
LADIERIAPLAEGAL

SLC25A12

286

O75746
ARGLQLSALALAPAE

CNNM3

151

Q8NE01
LERGQLEAARPLLAL

TNFAIP2

86

Q03169
VEEGARAPLENGLAL

TTBK1

971

Q5TCY1
VDRLPGLQGALDLLA

ZSWIM9

231

Q86XI8
NLAGEPRVIALELLD

UNC80

2516

Q8N2C7
GPSLALVLLRDNGLQ

NME8

381

Q8N427
LLVEGDIIALRPGQE

TMEM94

181

Q12767
VELALALRPGAAGDL

SH2D3A

396

Q9BRG2
DELPANILLVRLLDG

SH3RF3

106

Q8TEJ3
VLEDPLLVSLRLEGG

PLEKHG4B

396

Q96PX9
LGPASAAAENLVLLR

PLCH2

1401

O75038
LNLAERLGDAKPRGL

RNF44

341

Q7L0R7
SRLGALQGDPEALTL

VPS18

501

Q9P253
DGPAGALLLRLVQLA

AVP

136

P01185
AIEPDVLRQFLGLGI

WDFY4

916

Q6ZS81
GLAISLLGIGQPEEL

TTC3

541

P53804
SLARELLQLADALGP

UMPS

261

P11172
EPLGSAIARGDAELL

PRRT4

661

C9JH25
GLPNFLAVALALGEL

NAPRT

296

Q6XQN6
LLDAQLATGGIVDPR

PLEC

3936

Q15149
ALLLEGLSRILQDPA

ULK2

996

Q8IYT8
AQGLRELEGASDPLL

UBN1

276

Q9NPG3
EALPANLLLVRLLDG

SH3RF2

61

Q8TEC5
LIRDQDLGASLLPAA

ZNF18

206

P17022
PLGFLLLQLSGDLED

PLBD2

211

Q8NHP8
DAAALVAGRLLPVLV

TARBP1

186

Q13395
SLLLLGNEREGIPAN

TARBP1

1561

Q13395
ILLPEEQQLLLLGGG

LCMT2

646

O60294
EAQEGPRLLNLGALI

TSPY26P

131

Q9H489
GLLDALAEAERLGPL

VMAC

116

Q2NL98
RALIPLALEGTDVGQ

UNC45A

691

Q9H3U1
LGDIANILGPLRDQL

UTF1

286

Q5T230
LIRGLLENNLGEPIE

VPS13D

2246

Q5THJ4
GATDGPARLLNLDLD

KMT2D

5041

O14686
DNELAALAPGLLGRL

LRRC26

176

Q2I0M4