Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentciliary rootlet

KLC2 KLC1

1.63e-0416252GO:0035253
GeneOntologyCellularComponentheterochromatin

BAZ1B BEND3 DNMT3B

2.33e-04101253GO:0000792
GeneOntologyCellularComponentkinesin complex

KLC2 KLC1

1.56e-0349252GO:0005871
DomainKinesin_light_repeat

KLC2 KLC1

5.16e-063252IPR015792
DomainKINESIN_LIGHT

KLC2 KLC1

5.16e-063252PS01160
DomainKinesin_light

KLC2 KLC1

1.03e-054252IPR002151
Domain-

ZNF438 ZNF300 ZNF705B ZNF417 ZNF587 ZBTB14 ZNF705D

2.21e-056792573.30.160.60
Domainzf-C2H2

ZNF438 ZNF300 ZNF705B ZNF417 ZNF587 ZBTB14 ZNF705D

2.52e-05693257PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF438 ZNF300 ZNF705B ZNF417 ZNF587 ZBTB14 ZNF705D

2.54e-05694257IPR013087
DomainRabaptin_Rab5-bd_dom

KLC2 KLC1

2.57e-056252IPR015390
DomainTPR_10

KLC2 KLC1

2.57e-056252PF13374
DomainRab5-bind

KLC2 KLC1

2.57e-056252PF09311
DomainZINC_FINGER_C2H2_2

ZNF438 ZNF300 ZNF705B ZNF417 ZNF587 ZBTB14 ZNF705D

5.14e-05775257PS50157
DomainZINC_FINGER_C2H2_1

ZNF438 ZNF300 ZNF705B ZNF417 ZNF587 ZBTB14 ZNF705D

5.23e-05777257PS00028
DomainZnf_C2H2-like

ZNF438 ZNF300 ZNF705B ZNF417 ZNF587 ZBTB14 ZNF705D

6.10e-05796257IPR015880
DomainZnf_C2H2

ZNF438 ZNF300 ZNF705B ZNF417 ZNF587 ZBTB14 ZNF705D

6.55e-05805257IPR007087
DomainZnF_C2H2

ZNF438 ZNF300 ZNF705B ZNF417 ZNF587 ZBTB14 ZNF705D

6.70e-05808257SM00355
DomainKRAB

ZNF300 ZNF705B ZNF417 ZNF587 ZNF705D

9.75e-05358255PS50805
DomainKRAB

ZNF300 ZNF705B ZNF417 ZNF587 ZNF705D

9.75e-05358255PF01352
DomainKRAB

ZNF300 ZNF705B ZNF417 ZNF587 ZNF705D

1.12e-04369255SM00349
DomainKRAB

ZNF300 ZNF705B ZNF417 ZNF587 ZNF705D

1.14e-04370255IPR001909
DomainPentatricopeptide_repeat

KLC2 KLC1

4.28e-0423252IPR002885
DomainTPR_1

KLC2 KLC1

6.41e-0390252PF00515
DomainTPR_1

KLC2 KLC1

6.41e-0390252IPR001440
DomainZF_PHD_2

BAZ1B ASXL3

7.12e-0395252PS50016
DomainZF_PHD_1

BAZ1B ASXL3

7.26e-0396252PS01359
DomainTPR

KLC2 KLC1

1.28e-02129252SM00028
DomainTPR_repeat

KLC2 KLC1

1.36e-02133252IPR019734
DomainZnf_FYVE_PHD

BAZ1B DNMT3B

1.64e-02147252IPR011011
DomainTPR-contain_dom

KLC2 KLC1

1.70e-02150252IPR013026
DomainTPR

KLC2 KLC1

2.04e-02165252PS50005
DomainTPR_REGION

KLC2 KLC1

2.04e-02165252PS50293
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_ANTEROGRADE_AXONAL_TRANSPORT

KLC2 KLC1

4.90e-059172M47699
PathwayREACTOME_RHO_GTPASES_ACTIVATE_KTN1

KLC2 KLC1

7.48e-0511172MM15218
PathwayREACTOME_RHO_GTPASES_ACTIVATE_KTN1

KLC2 KLC1

7.48e-0511172M27490
PathwayKEGG_MEDICUS_VARIANT_OLIGOMERIC_CONFORMATION_PRPC_TO_ANTEROGRADE_AXONAL_TRANSPORT

KLC2 KLC1

1.06e-0413172M47763
PathwayKEGG_MEDICUS_REFERENCE_ANTEROGRADE_AXONAL_TRANSPORT

KLC2 KLC1

3.72e-0424172M47671
PathwayKEGG_MEDICUS_PATHOGEN_SALMONELLA_SIFA_TO_MICROTUBULE_PLUS_END_DIRECTED_TRANSPORT

KLC2 KLC1

4.04e-0425172M47775
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SNCA_TO_ANTEROGRADE_AXONAL_TRANSPORT

KLC2 KLC1

4.04e-0425172M47710
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_ANTEROGRADE_AXONAL_TRANSPORT

KLC2 KLC1

4.37e-0426172M47672
PathwayREACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION

ZNF300 BAZ1B DNMT3B

5.41e-04136173MM14848
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

SNAP23 KLC2 ARHGEF18 PTPN13 KLC1

7.94e-04649175MM15690
PathwayKEGG_MEDICUS_REFERENCE_ARL8_REGULATED_MICROTUBULE_PLUS_END_DIRECTED_TRANSPORT

KLC2 KLC1

7.96e-0435172M47774
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

SNAP23 KLC2 ARHGEF18 PTPN13 KLC1

1.27e-03720175M41838
PathwayREACTOME_KINESINS

KLC2 KLC1

2.10e-0357172MM15714
PathwayREACTOME_KINESINS

KLC2 KLC1

2.40e-0361172M977
Pubmed

Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain.

KLC2 KLC1

5.37e-07226229036226
Pubmed

Crystal structures of the tetratricopeptide repeat domains of kinesin light chains: insight into cargo recognition mechanisms.

KLC2 KLC1

5.37e-07226222470497
Pubmed

Cayman ataxia protein caytaxin is transported by kinesin along neurites through binding to kinesin light chains.

KLC2 KLC1

3.22e-06426219861499
Pubmed

Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein.

KLC2 KLC1

3.22e-06426211106729
Pubmed

Calsyntenin-1 docks vesicular cargo to kinesin-1.

KLC2 KLC1

5.37e-06526216760430
Pubmed

Sunday Driver/JIP3 binds kinesin heavy chain directly and enhances its motility.

KLC2 KLC1

5.37e-06526221750526
Pubmed

Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization.

KLC2 KLC1

5.37e-06526219164528
Pubmed

Defective kinesin heavy chain behavior in mouse kinesin light chain mutants.

KLC2 KLC1

5.37e-06526210491391
Pubmed

The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport.

KLC2 KLC1

1.13e-05726217332754
Pubmed

Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles.

KLC2 KLC1

1.13e-05726221335237
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

BEND3 PTPN13 ZMYM5 KLC1 WDR62

1.31e-0541826534709266
Pubmed

The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23.

SNAP23 KLC1

1.50e-05826212475239
Pubmed

RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery.

KLC2 KLC1

1.50e-05826234432492
Pubmed

Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins.

KLC2 KLC1

1.93e-0592629624122
Pubmed

Dynein and kinesin regulate stress-granule and P-body dynamics.

KLC2 KLC1

2.41e-051026219825938
Pubmed

A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome.

KLC2 KLC1

2.41e-051026221915095
Pubmed

The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos.

KLC2 KLC1

3.53e-051226216018997
Pubmed

Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1.

KLC2 KLC1

3.53e-051226216301330
Pubmed

An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse.

BAZ1B DNMT3B

8.16e-051826224025402
Pubmed

Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation.

KLC2 KLC1

9.12e-051926215529118
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

ARHGEF18 ZMYM5 KLC1 DNMT3B

2.78e-0443026435044719
Pubmed

α-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.

SNAP23 PTPN13

3.15e-043526237381005
Pubmed

SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.

ZNF300 BEND3 SPATA6 ZNF417 ZBTB14

5.18e-0491526532393512
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

BAZ1B BEND3 PTPN13 KLC1

6.97e-0454926438280479
InteractionZBTB43 interactions

ZNF417 ZNF587 ZBTB14

3.95e-0556243int:ZBTB43
InteractionCEP44 interactions

ZNF417 ZNF587 KLC1 WDR62

6.87e-05189244int:CEP44
InteractionKCTD7 interactions

ZNF438 ZNF417 ZNF587

1.19e-0481243int:KCTD7
InteractionZBTB8A interactions

ZNF438 ZNF417 ZNF587

1.19e-0481243int:ZBTB8A
InteractionPRICKLE4 interactions

ZNF417 ZNF587

1.83e-0417242int:PRICKLE4
InteractionZNF547 interactions

ZNF417 ZNF587

1.83e-0417242int:ZNF547
InteractionTSGA10 interactions

ZNF438 ZNF417 ZNF587

2.03e-0497243int:TSGA10
Cytoband19q13.43

ZNF417 ZNF587

1.12e-038726219q13.43
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF438 ZNF300 ZNF705B ZNF417 ZNF587 ZBTB14 ZNF705D

5.02e-0671819728
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

KLC2 KLC1

6.39e-03115192769
CoexpressionFIGUEROA_AML_METHYLATION_CLUSTER_2_DN

CD3G ASXL3

2.88e-059242M2163
CoexpressionGSE35543_IN_VITRO_ITREG_VS_CONVERTED_EX_ITREG_UP

CKAP2L PTPN13 WDR62 BBOF1

3.10e-05200244M9437
Drugpeimine

ZNF587 ZBTB14

2.49e-058222CID000131900
DrugKawain [500-64-1]; Down 200; 17.4uM; PC3; HT_HG-U133A

BAZ1B ZMYM5 GLRB DNMT3B

3.45e-051962247369_DN
DrugEtilefrine hydrochloride [534-87-2]; Down 200; 18.4uM; MCF7; HT_HG-U133A

BAZ1B ZBTB14 ZMYM5 WDR62

3.52e-051972247350_DN
DrugTocopherol (R,S) [10191-41-0]; Down 200; 9.2uM; HL60; HT_HG-U133A

SNAP23 BAZ1B KLC1 DNMT3B

3.59e-051982241320_DN
DrugMethazolamide [554-57-4]; Down 200; 17uM; MCF7; HT_HG-U133A

SNAP23 ARHGEF18 DNMT3B BBOF1

3.66e-051992246268_DN
DrugTriflupromazine hydrochloride [1098-60-8]; Down 200; 10.2uM; PC3; HT_HG-U133A

KLC2 BAZ1B GLRB BBOF1

3.66e-051992241813_DN
DrugChlorthalidone [77-36-1]; Up 200; 11.8uM; PC3; HT_HG-U133A

BAZ1B ZBTB14 ZMYM5 BBOF1

3.73e-052002247152_UP
DiseaseAlzheimer's disease 1 (implicated_via_orthology)

KLC2 KLC1

1.22e-057232DOID:0080348 (implicated_via_orthology)
Diseasehead and neck squamous cell carcinoma (is_implicated_in)

PTPN13 DNMT3B

6.06e-0515232DOID:5520 (is_implicated_in)
Diseaselung adenocarcinoma (is_implicated_in)

PTPN13 DNMT3B

6.68e-0449232DOID:3910 (is_implicated_in)
Diseaseoral squamous cell carcinoma (is_marker_for)

PTPN13 DNMT3B

1.10e-0363232DOID:0050866 (is_marker_for)
DiseaseSclerocystic Ovaries

ZMYM5 BBOF1

5.59e-03144232C1136382
DiseasePolycystic Ovary Syndrome

ZMYM5 BBOF1

5.59e-03144232C0032460
Diseasebrain measurement, neuroimaging measurement

ZNF438 BEND3 DNMT3B

8.64e-03550233EFO_0004346, EFO_0004464

Protein segments in the cluster

PeptideGeneStartEntry
YDCTNSPTKNGSFKK

ARHGEF18

916

Q6ZSZ5
PRGMYQCKGSQNKSK

CD3G

81

P09693
PKRLKTNCYNNGKDR

DNMT3B

396

Q9UBC3
KYTNNSEKPSGKRQC

BCORP1

91

Q8N888
DYCPRSKKANLGKNA

BAZ1B

951

Q9UIG0
SKKGKNLGQAYPCSS

DKK2

66

Q9UBU2
KMNGCPSRKYNQSSR

BBOF1

456

Q8ND07
GSSKQKEYLEQSCPK

ASXL3

1626

Q9C0F0
LRKQYNCSGSLGKKQ

BEND3

591

Q5T5X7
PECRATYQDQKNKKA

FAM47C

876

Q5HY64
KGKKKQYLCPSQQSA

GLRB

31

P48167
AKTKNNLASCYLKQG

KLC2

366

Q9H0B6
AKTKNNLASCYLKQG

KLC1

381

Q07866
KGKCSTYQIKGSPNL

PTPN13

2021

Q12923
PCNRTKNFESGKAYK

SNAP23

86

O00161
SQNTKPYLKSKNNCQ

CKAP2L

31

Q8IYA6
TLNKTSYPEKCQPNK

C12orf40

361

Q86WS4
NNGQSKSKYCLKINR

ZBTB14

136

O43829
QEGKTNYSCGKRTKA

ZNF587

206

Q96SQ5
QEGKTNYSCGKRTKA

ZNF417

206

Q8TAU3
NTVNGKQKKCYKGSQ

WDR62

656

O43379
PRKQIHTKGKSYQCN

ZNF705B

161

P0CI00
PRKQIHTKGKSYQCN

ZNF705D

161

P0CH99
NCKKPLQKGQTAYQR

ZMYM5

246

Q9UJ78
PKYLGCKQDNSSSPK

ZNF438

476

Q7Z4V0
SKSPERSKYCINAKN

SPATA6

191

Q9NWH7
PSCYKSNSRKKPDQS

ZNF300

201

Q96RE9