Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	L-serine-phosphatidylethanolamine phosphatidyltransferase activity	PTDSS1 PTDSS2	6.91e-06	2	53	2	GO:0106245
GeneOntologyMolecularFunction	transmembrane transporter activity	TMC1 CLCN7 SLC50A1 SLC15A4 PEX2 SLC9A7 GRIA2 ABCC12 ASIC5 ABCA10 ANO3 GABRA2 GABRA3	9.19e-06	1180	53	13	GO:0022857
GeneOntologyMolecularFunction	transporter activity	TMC1 CLCN7 SLC50A1 SLC15A4 PEX2 SLC9A7 GRIA2 ABCC12 ASIC5 ABCA10 ANO3 GABRA2 GABRA3	2.36e-05	1289	53	13	GO:0005215
GeneOntologyMolecularFunction	phosphotransferase activity, for other substituted phosphate groups	SGMS2 PTDSS1 PTDSS2	2.62e-05	22	53	3	GO:0016780
GeneOntologyMolecularFunction	gated channel activity	TMC1 CLCN7 GRIA2 ASIC5 ANO3 GABRA2 GABRA3	2.74e-05	334	53	7	GO:0022836
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	GRIA2 GABRA2 GABRA3	3.44e-05	24	53	3	GO:0099507
GeneOntologyMolecularFunction	hyaluronan synthase activity	HAS1 HAS2	4.13e-05	4	53	2	GO:0050501
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	GRIA2 HRH4 GABRA2 GABRA3	4.68e-05	75	53	4	GO:0098960
GeneOntologyMolecularFunction	bitter taste receptor activity	TAS2R8 TAS2R5 TAS2R33	4.94e-05	27	53	3	GO:0033038
GeneOntologyMolecularFunction	chloride channel activity	CLCN7 ANO3 GABRA2 GABRA3	7.99e-05	86	53	4	GO:0005254
GeneOntologyMolecularFunction	taste receptor activity	TAS2R8 TAS2R5 TAS2R33	9.11e-05	33	53	3	GO:0008527
GeneOntologyMolecularFunction	neurotransmitter receptor activity	GRIA2 HRH4 GABRA2 GABRA3	1.44e-04	100	53	4	GO:0030594
GeneOntologyMolecularFunction	G protein-coupled receptor kinase activity	GRK4 GRK6	1.44e-04	7	53	2	GO:0004703
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	TMC1 CLCN7 SLC15A4 SLC9A7 GRIA2 ASIC5 ANO3 GABRA2 GABRA3	1.55e-04	758	53	9	GO:0015318
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	GRIA2 ASIC5 ANO3 GABRA2 GABRA3	1.58e-04	193	53	5	GO:0015276
GeneOntologyMolecularFunction	monoatomic anion channel activity	CLCN7 ANO3 GABRA2 GABRA3	1.61e-04	103	53	4	GO:0005253
GeneOntologyMolecularFunction	ligand-gated channel activity	GRIA2 ASIC5 ANO3 GABRA2 GABRA3	1.74e-04	197	53	5	GO:0022834
GeneOntologyMolecularFunction	monoatomic ion channel activity	TMC1 CLCN7 GRIA2 ASIC5 ANO3 GABRA2 GABRA3	2.00e-04	459	53	7	GO:0005216
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	TMC1 CLCN7 SLC15A4 SLC9A7 GRIA2 ASIC5 ANO3 GABRA2 GABRA3	2.17e-04	793	53	9	GO:0015075
GeneOntologyMolecularFunction	ligand-gated monoatomic anion channel activity	ANO3 GABRA2 GABRA3	3.17e-04	50	53	3	GO:0099095
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	CLCN7 ANO3 GABRA2 GABRA3	3.38e-04	125	53	4	GO:0015108
GeneOntologyMolecularFunction	ATP-dependent protein binding	PLK2 DNAJC5	3.74e-04	11	53	2	GO:0043008
GeneOntologyMolecularFunction	benzodiazepine receptor activity	GABRA2 GABRA3	3.74e-04	11	53	2	GO:0008503
GeneOntologyMolecularFunction	channel activity	TMC1 CLCN7 GRIA2 ASIC5 ANO3 GABRA2 GABRA3	4.51e-04	525	53	7	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	TMC1 CLCN7 GRIA2 ASIC5 ANO3 GABRA2 GABRA3	4.56e-04	526	53	7	GO:0022803
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	GRIA2 GABRA2 GABRA3	4.67e-04	57	53	3	GO:1904315
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	GRIA2 GABRA2 GABRA3	5.43e-04	60	53	3	GO:0099529
GeneOntologyMolecularFunction	transmitter-gated channel activity	GRIA2 GABRA2 GABRA3	6.87e-04	65	53	3	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	GRIA2 GABRA2 GABRA3	6.87e-04	65	53	3	GO:0022824
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	CLCN7 ANO3 GABRA2 GABRA3	6.90e-04	151	53	4	GO:0008509
GeneOntologyMolecularFunction	GABA-gated chloride ion channel activity	GABRA2 GABRA3	1.03e-03	18	53	2	GO:0022851
GeneOntologyMolecularFunction	ligand-gated sodium channel activity	GRIA2 ASIC5	1.03e-03	18	53	2	GO:0015280
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	CLCN7 ANO3 GABRA2 GABRA3	1.10e-03	171	53	4	GO:0015103
GeneOntologyMolecularFunction	extracellular ligand-gated monoatomic ion channel activity	GRIA2 GABRA2 GABRA3	1.12e-03	77	53	3	GO:0005230
GeneOntologyMolecularFunction	GABA-A receptor activity	GABRA2 GABRA3	1.15e-03	19	53	2	GO:0004890
GeneOntologyMolecularFunction	GABA receptor activity	GABRA2 GABRA3	1.54e-03	22	53	2	GO:0016917
GeneOntologyMolecularFunction	macromolecule transmembrane transporter activity	SLC15A4 PEX2	3.67e-03	34	53	2	GO:0022884
GeneOntologyMolecularFunction	glycosyltransferase activity	GALNTL5 EXT2 HAS1 HAS2	7.13e-03	288	53	4	GO:0016757
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCC12 ABCA10	7.51e-03	49	53	2	GO:0140359
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	EXT2 HAS1 HAS2	7.81e-03	153	53	3	GO:0008194
GeneOntologyMolecularFunction	sodium channel activity	GRIA2 ASIC5	8.42e-03	52	53	2	GO:0005272
GeneOntologyMolecularFunction	active transmembrane transporter activity	CLCN7 SLC15A4 SLC9A7 ABCC12 ABCA10	8.52e-03	477	53	5	GO:0022804
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	TAS2R8 TAS2R5 TAS2R33 ADGRG1 GRIA2 HRH4 TACR3 GABRA2 GABRA3	8.68e-03	1353	53	9	GO:0004888
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC9A7 GRIA2 ASIC5	1.06e-02	171	53	3	GO:0015081
GeneOntologyMolecularFunction	carbohydrate derivative transmembrane transporter activity	SLC50A1 SLC15A4	1.07e-02	59	53	2	GO:1901505
GeneOntologyMolecularFunction	proton transmembrane transporter activity	SLC15A4 SLC9A7 ASIC5	1.36e-02	188	53	3	GO:0015078
GeneOntologyBiologicalProcess	phosphatidylserine biosynthetic process	PTDSS1 PTDSS2	3.87e-05	4	53	2	GO:0006659
GeneOntologyBiologicalProcess	regulation of postsynaptic membrane potential	PLK2 RAB3GAP1 GRIA2 GABRA2 GABRA3	9.79e-05	180	53	5	GO:0060078
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	TMC1 CLCN7 SLC15A4 WWP1 SLC9A7 GRIA2 ASIC5 MICU2 ANO3 GABRA2 GABRA3	1.03e-04	1115	53	11	GO:0034220
GeneOntologyBiologicalProcess	monoatomic ion transport	TMC1 ZMPSTE24 CLCN7 SLC15A4 WWP1 SLC9A7 GRIA2 ASIC5 MICU2 ANO3 GABRA2 GABRA3	1.51e-04	1374	53	12	GO:0006811
GeneOntologyBiologicalProcess	chloride transmembrane transport	CLCN7 ANO3 GABRA2 GABRA3	1.97e-04	112	53	4	GO:1902476
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of bitter taste	TAS2R8 TAS2R5 TAS2R33	1.97e-04	44	53	3	GO:0001580
GeneOntologyCellularComponent	endoplasmic reticulum membrane	RAB3GAP1 SGMS2 ZMPSTE24 DNAJC25 SURF4 DHCR7 PTDSS1 DIO1 ABCC12 PTDSS2 EXT2 TMEM39A HAS2 PHTF1	3.50e-06	1293	54	14	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	RAB3GAP1 SGMS2 ZMPSTE24 DNAJC25 SURF4 DHCR7 PTDSS1 DIO1 ABCC12 PTDSS2 EXT2 TMEM39A HAS2 PHTF1	3.70e-06	1299	54	14	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	RAB3GAP1 SGMS2 ZMPSTE24 DNAJC25 SURF4 DHCR7 PTDSS1 DIO1 ABCC12 PTDSS2 EXT2 TMEM39A HAS2 PHTF1	4.74e-06	1327	54	14	GO:0042175
GeneOntologyCellularComponent	dendrite membrane	GRIA2 TACR3 GABRA2 GABRA3	1.32e-05	56	54	4	GO:0032590
GeneOntologyCellularComponent	neuron projection membrane	GRIA2 TACR3 GABRA2 GABRA3	5.99e-05	82	54	4	GO:0032589
GeneOntologyCellularComponent	chloride channel complex	CLCN7 GABRA2 GABRA3	4.32e-04	57	54	3	GO:0034707
GeneOntologyCellularComponent	presynaptic active zone membrane	GRIA2 GABRA2 GABRA3	1.08e-03	78	54	3	GO:0048787
GeneOntologyCellularComponent	GABA-A receptor complex	GABRA2 GABRA3	1.09e-03	19	54	2	GO:1902711
GeneOntologyCellularComponent	GABA receptor complex	GABRA2 GABRA3	1.33e-03	21	54	2	GO:1902710
GeneOntologyCellularComponent	leading edge membrane	GRIA2 TACR3 GABRA2 GABRA3	2.11e-03	210	54	4	GO:0031256
Domain	TF_homeodomain_male	PHTF2 PHTF1	7.90e-06	2	53	2	IPR021980
Domain	PSS	PTDSS1 PTDSS2	7.90e-06	2	53	2	IPR004277
Domain	Phtf-FEM1B_bdg	PHTF2 PHTF1	7.90e-06	2	53	2	PF12129
Domain	PSS	PTDSS1 PTDSS2	7.90e-06	2	53	2	PF03034
Domain	HAS/NodC	HAS1 HAS2	2.37e-05	3	53	2	IPR026107
Domain	-	GALNTL5 EXT2 HAS1 HAS2	8.18e-05	81	53	4	3.90.550.10
Domain	Glyco_trans_2-like	GALNTL5 HAS1 HAS2	8.30e-05	30	53	3	IPR001173
Domain	Glycos_transf_2	GALNTL5 HAS1 HAS2	8.30e-05	30	53	3	PF00535
Domain	Nucleotide-diphossugar_trans	GALNTL5 EXT2 HAS1 HAS2	1.13e-04	88	53	4	IPR029044
Domain	GABAAa_rcpt	GABRA2 GABRA3	1.18e-04	6	53	2	IPR001390
Domain	GPCR_kinase	GRK4 GRK6	1.64e-04	7	53	2	IPR000239
Domain	GABAA/Glycine_rcpt	GABRA2 GABRA3	1.92e-03	23	53	2	IPR006028
Domain	TAS2R	TAS2R8 TAS2R5	2.46e-03	26	53	2	PF05296
Domain	T2R	TAS2R8 TAS2R5	2.46e-03	26	53	2	IPR007960
Domain	RGS	GRK4 GRK6	4.43e-03	35	53	2	PF00615
Domain	RGS	GRK4 GRK6	4.43e-03	35	53	2	SM00315
Domain	RGS	GRK4 GRK6	4.68e-03	36	53	2	PS50132
Domain	RGS	GRK4 GRK6	5.47e-03	39	53	2	IPR016137
Domain	ABC_transporter_CS	ABCC12 ABCA10	6.33e-03	42	53	2	IPR017871
Domain	Neurotransmitter_ion_chnl_CS	GABRA2 GABRA3	7.23e-03	45	53	2	IPR018000
Domain	Neur_chan_memb	GABRA2 GABRA3	7.55e-03	46	53	2	PF02932
Domain	Neur_chan_LBD	GABRA2 GABRA3	7.87e-03	47	53	2	PF02931
Domain	Neur_channel	GABRA2 GABRA3	7.87e-03	47	53	2	IPR006201
Domain	Neur_chan_lig-bd	GABRA2 GABRA3	7.87e-03	47	53	2	IPR006202
Domain	NEUROTR_ION_CHANNEL	GABRA2 GABRA3	7.87e-03	47	53	2	PS00236
Domain	Neurotrans-gated_channel_TM	GABRA2 GABRA3	7.87e-03	47	53	2	IPR006029
Domain	-	GABRA2 GABRA3	7.87e-03	47	53	2	2.70.170.10
Domain	DnaJ	DNAJC25 DNAJC5	8.20e-03	48	53	2	PF00226
Domain	ABC_TRANSPORTER_2	ABCC12 ABCA10	8.20e-03	48	53	2	PS50893
Domain	ABC_tran	ABCC12 ABCA10	8.20e-03	48	53	2	PF00005
Domain	ABC_TRANSPORTER_1	ABCC12 ABCA10	8.53e-03	49	53	2	PS00211
Domain	DnaJ	DNAJC25 DNAJC5	8.53e-03	49	53	2	SM00271
Domain	DNAJ_1	DNAJC25 DNAJC5	8.53e-03	49	53	2	PS00636
Domain	DNAJ_2	DNAJC25 DNAJC5	8.53e-03	49	53	2	PS50076
Domain	-	DNAJC25 DNAJC5	8.53e-03	49	53	2	1.10.287.110
Domain	ABC_transporter-like	ABCC12 ABCA10	8.87e-03	50	53	2	IPR003439
Domain	DnaJ_domain	DNAJC25 DNAJC5	9.22e-03	51	53	2	IPR001623
Domain	AGC-kinase_C	GRK4 GRK6	1.10e-02	56	53	2	IPR000961
Domain	AGC_KINASE_CTER	GRK4 GRK6	1.10e-02	56	53	2	PS51285
Domain	S_TK_X	GRK4 GRK6	1.10e-02	56	53	2	SM00133
Pathway	REACTOME_HYALURONAN_BIOSYNTHESIS_AND_EXPORT	HAS1 HAS2	1.08e-04	5	47	2	MM14865
Pathway	REACTOME_HYALURONAN_BIOSYNTHESIS_AND_EXPORT	HAS1 HAS2	1.08e-04	5	47	2	M27144
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	CLCN7 SLC50A1 LIPG SLC15A4 WWP1 SLC9A7 ASIC5 MICU2 ABCA10 ANO3	1.26e-04	736	47	10	M27287
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	CLCN7 WWP1 ASIC5 ANO3	3.24e-04	99	47	4	MM14910
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	CLCN7 SLC50A1 LIPG SLC15A4 WWP1 SLC9A7 ASIC5 MICU2 ANO3	3.55e-04	681	47	9	MM14985
Pathway	BIOCARTA_FLUMAZENIL_PATHWAY	GABRA2 GABRA3	3.86e-04	9	47	2	M22034
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	CLCN7 WWP1 ASIC5 ANO3	4.20e-04	106	47	4	M27200
Pathway	BIOCARTA_GABA_PATHWAY	GABRA2 GABRA3	4.81e-04	10	47	2	MM1401
Pathway	BIOCARTA_GABA_PATHWAY	GABRA2 GABRA3	4.81e-04	10	47	2	M477
Pathway	WP_EFFECT_OF_OMEGA3_PUFA_ON_HUNTINGTONS_DISEASE_PATHWAYS	RAB3GAP1 DHCR7 GABRA2 GABRA3	6.51e-04	119	47	4	M48309
Pathway	WP_KENNEDY_PATHWAY	PTDSS1 PTDSS2	9.65e-04	14	47	2	MM15980
Pathway	WP_KENNEDY_PATHWAY_FROM_SPHINGOLIPIDS	PTDSS1 PTDSS2	9.65e-04	14	47	2	M39620
Pathway	REACTOME_HYALURONAN_METABOLISM	HAS1 HAS2	1.43e-03	17	47	2	M666
Pathway	REACTOME_HYALURONAN_METABOLISM	HAS1 HAS2	1.43e-03	17	47	2	MM14864
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	GRIA2 HRH4 TACR3 GABRA2 GABRA3	2.04e-03	272	47	5	M13380
Pubmed	Hyaluronan Synthases' Expression and Activity Are Induced by Fluid Shear Stress in Bone Marrow-Derived Mesenchymal Stem Cells.	HAS1 HAS2	2.37e-06	2	54	2	33803805
Pubmed	Defining the importance of phosphatidylserine synthase-1 (PSS1): unexpected viability of PSS1-deficient mice.	PTDSS1 PTDSS2	2.37e-06	2	54	2	18343815
Pubmed	Dynamic changes in cervical glycosaminoglycan composition during normal pregnancy and preterm birth.	HAS1 HAS2	2.37e-06	2	54	2	22529214
Pubmed	Differential roles of GABA(A) receptor subtypes in benzodiazepine-induced enhancement of brain-stimulation reward.	GABRA2 GABRA3	2.37e-06	2	54	2	22763624
Pubmed	Transient expression of GABAA receptor alpha2 and alpha3 subunits in differentiating cerebellar neurons.	GABRA2 GABRA3	2.37e-06	2	54	2	14766194
Pubmed	Coding sequence of a hyaluronan synthase homologue expressed during expansion of the mouse cumulus-oocyte complex.	HAS1 HAS2	2.37e-06	2	54	2	9016821
Pubmed	Molecular and neuronal substrate for the selective attenuation of anxiety.	GABRA2 GABRA3	2.37e-06	2	54	2	11021797
Pubmed	Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma.	HAS1 HAS2	2.37e-06	2	54	2	27184066
Pubmed	Cloning and expression of murine liver phosphatidylserine synthase (PSS)-2: differential regulation of phospholipid metabolism by PSS1 and PSS2.	PTDSS1 PTDSS2	2.37e-06	2	54	2	10432300
Pubmed	Hyaluronic acid, HAS1, and HAS2 are significantly upregulated during muscle hypertrophy.	HAS1 HAS2	2.37e-06	2	54	2	22785117
Pubmed	Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.	PTDSS1 PTDSS2	2.37e-06	2	54	2	10938271
Pubmed	Deficiency of hyaluronan synthase 1 (Has1) results in chronic joint inflammation and widespread intra-articular fibrosis in a murine model of knee joint cartilage damage.	HAS1 HAS2	2.37e-06	2	54	2	26521733
Pubmed	Neural basis of benzodiazepine reward: requirement for α2 containing GABAA receptors in the nucleus accumbens.	GABRA2 GABRA3	2.37e-06	2	54	2	24553732
Pubmed	Reversal of pathological pain through specific spinal GABAA receptor subtypes.	GABRA2 GABRA3	2.37e-06	2	54	2	18202657
Pubmed	Linking GABA(A) receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication.	GABRA2 GABRA3	2.37e-06	2	54	2	23147414
Pubmed	Defining the importance of phosphatidylserine synthase 2 in mice.	PTDSS1 PTDSS2	2.37e-06	2	54	2	12361952
Pubmed	Functional expression of the GABA(A) receptor α2 and α3 subunits at synapses between intercalated medial paracapsular neurons of mouse amygdala.	GABRA2 GABRA3	2.37e-06	2	54	2	22666188
Pubmed	Structure and expression of the murine phosphatidylserine synthase-1 gene.	PTDSS1 PTDSS2	2.37e-06	2	54	2	11084049
Pubmed	Dissecting the role of diazepam-sensitive γ-aminobutyric acid type A receptors in defensive behavioral reactivity to mild threat.	GABRA2 GABRA3	2.37e-06	2	54	2	23067879
Pubmed	Enrichment of GABAA Receptor α-Subunits on the Axonal Initial Segment Shows Regional Differences.	GABRA2 GABRA3	2.37e-06	2	54	2	26973458
Pubmed	Molecular characterization of a novel gene family (PHTF) conserved from Drosophila to mammals.	PHTF2 PHTF1	2.37e-06	2	54	2	10729229
Pubmed	Purification and characterization of human phosphatidylserine synthases 1 and 2.	PTDSS1 PTDSS2	2.37e-06	2	54	2	19014349
Pubmed	Hyaluronan deficiency in tumor stroma impairs macrophage trafficking and tumor neovascularization.	HAS1 HAS2	2.37e-06	2	54	2	20823158
Pubmed	Functional mapping of GABA A receptor subtypes in the amygdala.	GABRA2 GABRA3	2.37e-06	2	54	2	15341600
Pubmed	Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors.	GABRA2 GABRA3	2.37e-06	2	54	2	8391122
Pubmed	Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties.	HAS1 HAS2	7.09e-06	3	54	2	10455188
Pubmed	Expression of hyaluronan synthase genes in umbilical cord blood stem/progenitor cells.	HAS1 HAS2	7.09e-06	3	54	2	16564133
Pubmed	Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family.	HAS1 HAS2	7.09e-06	3	54	2	9442026
Pubmed	Analysis of human hyaluronan synthase gene transcriptional regulation and downstream hyaluronan cell surface receptor mobility in myofibroblast differentiation.	HAS1 HAS2	7.09e-06	3	54	2	25325984
Pubmed	Mammalian hyaluronan synthases: investigation of functional relationships in vivo.	HAS1 HAS2	7.09e-06	3	54	2	10093717
Pubmed	Cyclooxygenase inhibitors repress vascular hyaluronan-synthesis in murine atherosclerosis and neointimal thickening.	HAS1 HAS2	7.09e-06	3	54	2	19320776
Pubmed	Hyaluronan deficiency due to Has3 knock-out causes altered neuronal activity and seizures via reduction in brain extracellular space.	HAS1 HAS2	7.09e-06	3	54	2	24790187
Pubmed	Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons.	GABRA2 GABRA3	7.09e-06	3	54	2	16835366
Pubmed	The alpha 1, alpha 2, and alpha 3 subunits of GABAA receptors: comparison in seizure-prone and -resistant mice and during development.	GABRA2 GABRA3	7.09e-06	3	54	2	1356407
Pubmed	An in situ hybridization study of Hyaluronan synthase (Has) mRNA in developing mouse molar and incisor tooth germs.	HAS1 HAS2	7.09e-06	3	54	2	27289075
Pubmed	Perturbation of hyaluronan synthesis in the trabecular meshwork and the effects on outflow facility.	HAS1 HAS2	7.09e-06	3	54	2	22695958
Pubmed	Three vertebrate hyaluronan synthases are expressed during mouse development in distinct spatial and temporal patterns.	HAS1 HAS2	7.09e-06	3	54	2	15765504
Pubmed	Hyaluronan Modulates the Biomechanical Properties of the Cornea.	HAS1 HAS2	7.09e-06	3	54	2	36478198
Pubmed	Hyaluronan Regulates Eyelid and Meibomian Gland Morphogenesis.	HAS1 HAS2	7.09e-06	3	54	2	30046813
Pubmed	TNF-alpha, IFN-gamma, and IL-1beta modulate hyaluronan synthase expression in human skin fibroblasts: synergistic effect by concomital treatment with FeSO4 plus ascorbate.	HAS1 HAS2	7.09e-06	3	54	2	16786194
Pubmed	Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3.	HAS1 HAS2	7.09e-06	3	54	2	25795779
Pubmed	Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3.	HAS1 HAS2	7.09e-06	3	54	2	23303191
Pubmed	Hyaluronan Derived From the Limbus is a Key Regulator of Corneal Lymphangiogenesis.	HAS1 HAS2	7.09e-06	3	54	2	30897620
Pubmed	The effects of the nonselective benzodiazepine lorazepam and the α2 /α3 subunit-selective GABAA receptor modulators AZD7325 and AZD6280 on plasma prolactin levels.	GABRA2 GABRA3	7.09e-06	3	54	2	27128218
Pubmed	Analysis of hyaluronic acid in the endometrium of women with polycystic ovary syndrome.	HAS1 HAS2	7.09e-06	3	54	2	30614308
Pubmed	Hyaluronan expressed by the hematopoietic microenvironment is required for bone marrow hematopoiesis.	HAS1 HAS2	7.09e-06	3	54	2	22654110
Pubmed	Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells.	HAS1 HAS2	7.09e-06	3	54	2	11790779
Pubmed	In vitro synthesis of hyaluronan by a single protein derived from mouse HAS1 gene and characterization of amino acid residues essential for the activity.	HAS1 HAS2	7.09e-06	3	54	2	10617644
Pubmed	Specific GABAA circuits for visual cortical plasticity.	GABRA2 GABRA3	7.09e-06	3	54	2	15017002
Pubmed	Involvement of hyaluronan in regulation of fibroblast phenotype.	HAS1 HAS2	7.09e-06	3	54	2	17611197
Pubmed	Association of hyaluronic acid family members (HAS1, HAS2, and HYAL-1) with bladder cancer diagnosis and prognosis.	HAS1 HAS2	7.09e-06	3	54	2	20960509
Pubmed	Hyaluronan synthases.	HAS1 HAS2	7.09e-06	3	54	2	9206724
Pubmed	Expression regulation of hyaluronan synthase in corneal endothelial cells.	HAS1 HAS2	7.09e-06	3	54	2	11006212
Pubmed	Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes.	HAS1 HAS2	7.09e-06	3	54	2	24057227
Pubmed	Analysis of the presence and abundance of GABAA receptors containing two different types of alpha subunits in murine brain using point-mutated alpha subunits.	GABRA2 GABRA3	7.09e-06	3	54	2	15304513
Pubmed	Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells.	HAS1 HAS2	7.09e-06	3	54	2	11431361
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	RAB3GAP1 ZMPSTE24 CLCN7 SURF4 DHCR7 SUN1 PTDSS2	7.84e-06	468	54	7	31056421
Pubmed	Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.	GRIA2 TACR3 GABRA2 GABRA3	7.90e-06	81	54	4	22723691
Pubmed	Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor.	GRK4 GRK6	1.42e-05	4	54	2	10379886
Pubmed	Hyaluronan in cervical epithelia protects against infection-mediated preterm birth.	HAS1 HAS2	1.42e-05	4	54	2	25384213
Pubmed	Dynamic states of cervical epithelia during pregnancy and epithelial barrier disruption.	HAS1 HAS2	1.42e-05	4	54	2	36718364
Pubmed	Inverse expression of hyaluronidase 2 and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma.	HAS1 HAS2	1.42e-05	4	54	2	23560496
Pubmed	Putative hyaluronan synthase mRNA are expressed in mouse skin and TGF-beta upregulates their expression in cultured human skin cells.	HAS1 HAS2	1.42e-05	4	54	2	9457904
Pubmed	Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness.	ZMPSTE24 SUN1	1.42e-05	4	54	2	30282816
Pubmed	The control and importance of hyaluronan synthase expression in palatogenesis.	HAS1 HAS2	1.42e-05	4	54	2	23382716
Pubmed	Association study between GABA receptor genes and anxiety spectrum disorders.	GABRA2 GABRA3	1.42e-05	4	54	2	19842164
Pubmed	Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype.	GABRA2 GABRA3	1.42e-05	4	54	2	25865415
Pubmed	Hyaluronan synthase induction and hyaluronan accumulation in mouse epidermis following skin injury.	HAS1 HAS2	1.42e-05	4	54	2	15854028
Pubmed	The α1, α2, α3, and γ2 subunits of GABAA receptors show characteristic spatial and temporal expression patterns in rhombencephalic structures during normal human brain development.	GABRA2 GABRA3	1.42e-05	4	54	2	26518133
Pubmed	Hyaluronan Rich Microenvironment in the Limbal Stem Cell Niche Regulates Limbal Stem Cell Differentiation.	HAS1 HAS2	1.42e-05	4	54	2	28863216
Pubmed	Peritoneal adhesion and angiogenesis in ovarian carcinoma are inversely regulated by hyaluronan: the role of gonadotropins.	HAS1 HAS2	1.42e-05	4	54	2	20072653
Pubmed	Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.	GABRA2 GABRA3	1.42e-05	4	54	2	25080596
Pubmed	Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta.	HAS1 HAS2	1.42e-05	4	54	2	14636845
Pubmed	Nitric oxide alters hyaluronan deposition by airway smooth muscle cells.	HAS1 HAS2	1.42e-05	4	54	2	29966020
Pubmed	GABA(A) receptor downregulation in brains of subjects with autism.	GABRA2 GABRA3	1.42e-05	4	54	2	18821008
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	RAB3GAP1 ZMPSTE24 DNAJC25 SURF4 DHCR7 GRK6 SUN1 PTDSS1 EXT2	1.46e-05	952	54	9	38569033
Pubmed	Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYAL1 and hyaluronan content.	HAS1 HAS2	2.36e-05	5	54	2	19435493
Pubmed	Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma.	HAS1 HAS2	2.36e-05	5	54	2	20875124
Pubmed	Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors.	GABRA2 GABRA3	2.36e-05	5	54	2	30104684
Pubmed	A pericellular hyaluronan matrix is required for the morphological maturation of cortical neurons.	HAS1 HAS2	2.36e-05	5	54	2	32623025
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	ZMPSTE24 CLCN7 SLC15A4 WWP1 SURF4 NEMF PEX2 ADGRG1 PTDSS2	3.43e-05	1061	54	9	33845483
Pubmed	GABAA receptor signaling in caudal periaqueductal gray regulates maternal aggression and maternal care in mice.	GABRA2 GABRA3	3.54e-05	6	54	2	20457185
Pubmed	Modelling extracellular domains of GABA-A receptors: subtypes 1, 2, 3, and 5.	GABRA2 GABRA3	3.54e-05	6	54	2	15033447
Pubmed	bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells.	HAS1 HAS2	3.54e-05	6	54	2	19577615
Pubmed	The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation.	GRK4 GRK6	3.54e-05	6	54	2	10506199
Pubmed	FGF9 Promotes Expression of HAS2 in Palatal Elevation via the Wnt/β-Catenin/TCF7L2 Pathway.	HAS1 HAS2	3.54e-05	6	54	2	36358989
Pubmed	Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.	GRK4 GRK6	4.94e-05	7	54	2	8672451
Pubmed	Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199) and HA Synthases in Growth Factor-stimulated Fibroblasts.	HAS1 HAS2	4.94e-05	7	54	2	26518873
Pubmed	Developmental changes in the expression of gamma-aminobutyric acidA/benzodiazepine receptor subunit mRNAs in the murine inferior olivary complex.	GABRA2 GABRA3	4.94e-05	7	54	2	7560270
Pubmed	Lamina-specific alterations in cortical GABA(A) receptor subunit expression in schizophrenia.	GABRA2 GABRA3	4.94e-05	7	54	2	20843900
Pubmed	Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO).	GABRA2 GABRA3	4.94e-05	7	54	2	35228700
Pubmed	Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.	GRK4 GRK6	4.94e-05	7	54	2	11517230
Pubmed	Developmental changes in GABA receptor subunit composition within the gonadotrophin-releasing hormone-1 neuronal system.	GABRA2 GABRA3	4.94e-05	7	54	2	16101898
Pubmed	gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties.	GABRA2 GABRA3	6.59e-05	8	54	2	8175718
Pubmed	Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB.	HAS1 HAS2	6.59e-05	8	54	2	17324121
Pubmed	GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1.	GABRA2 GABRA3	6.59e-05	8	54	2	11528422
Pubmed	L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.	GRK4 GRK6 TRAPPC10 ADGRG1	7.39e-05	143	54	4	20424473
Pubmed	Loss of postsynaptic GABA(A) receptor clustering in gephyrin-deficient mice.	GRIA2 GABRA2	8.46e-05	9	54	2	10531433
Pubmed	The human ATP-binding cassette (ABC) transporter superfamily.	ABCC12 ABCA10	1.06e-04	10	54	2	11435397
Pubmed	Inhibitory synapse dysfunction and epileptic susceptibility associated with KIF2A deletion in cortical interneurons.	GABRA2 GABRA3	1.06e-04	10	54	2	36733270
Interaction	DNAJC25 interactions	RAB3GAP1 DNAJC25 SURF4 DHCR7 SUN1 PTDSS1 EXT2	9.08e-06	284	53	7	int:DNAJC25
Interaction	SEC61B interactions	FREM2 RAB3GAP1 ZMPSTE24 CLCN7 DNAJC25 SURF4 DHCR7 SUN1 NEMF PTDSS1	2.54e-05	763	53	10	int:SEC61B
Interaction	TCTN3 interactions	ZMPSTE24 CLCN7 SURF4 DHCR7 SUN1 PTDSS1 PTDSS2	2.58e-05	334	53	7	int:TCTN3
Interaction	LNPK interactions	RAB3GAP1 ZMPSTE24 DNAJC25 DHCR7 SUN1 DNAJC5 GRIA2	3.81e-05	355	53	7	int:LNPK
Interaction	GRAMD1B interactions	DNAJC25 DHCR7 TRAPPC10 GRIA2	4.51e-05	75	53	4	int:GRAMD1B
Interaction	SEC62 interactions	RAB3GAP1 ZMPSTE24 CLCN7 SURF4 DHCR7 SUN1 PTDSS1 GRIA2	4.91e-05	506	53	8	int:SEC62
Interaction	VAPA interactions	RAB3GAP1 ZMPSTE24 DNAJC25 SURF4 DHCR7 GRK6 SUN1 PHTF2 GRIA2	6.75e-05	686	53	9	int:VAPA
Cytoband	4q32.1	GRIA2 ASIC5	4.18e-04	26	53	2	4q32.1
GeneFamily	Glycosyltransferase family 2	HAS1 HAS2	6.08e-05	6	37	2	428
GeneFamily	Taste 2 receptors	TAS2R8 TAS2R5 TAS2R33	6.85e-05	39	37	3	1162
GeneFamily	Gamma-aminobutyric acid type A receptor subunits	GABRA2 GABRA3	6.82e-04	19	37	2	563
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	DNAJC25 DNAJC5	4.51e-03	49	37	2	584
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Striatum / BrainAtlas - Mouse McCarroll V32	PLK2 GRIA2 HAS1 ANO3 GABRA2	2.95e-06	188	53	5	e34ea7014c5a059a7db38f78bd903cf02616ddd3
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-midbrain/hindbrain_cells\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	TAS2R5 DNAJC5 TACR3 GABRA2	3.39e-05	154	53	4	df1b58a20af73fa79c6c069c0117a9ffd85b476f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SNED1 PHTF2 CDH7 ANO3	4.03e-05	161	53	4	1b805f77790aeb8a71b08bfac2fe2eed7343258f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PHTF2 ABCC12 CDH7 ANO3	4.34e-05	164	53	4	f6a961fa2002da7d9679f32af99e1314c0593ef9
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCC12 ASIC5 CDH7 ANO3	5.10e-05	171	53	4	f648789e6aefe508bb748401bf9b3cd830fb0ddf
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCC12 ASIC5 CDH7 ANO3	5.10e-05	171	53	4	6a489a75eeab2a2d48d604682e93599c20a945fe
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCC12 ASIC5 CDH7 ANO3	5.58e-05	175	53	4	06af6629766e2054e6995e8cdb3907658fec49d3
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-5\|TCGA-Skin / Sample_Type by Project: Shred V9	FREM2 SLC9A7 GRIA2 ANO3	5.96e-05	178	53	4	ad5cd505ca1cef8ac29b2af7e2c3e01ebc140c14
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCC12 ASIC5 CDH7 ANO3	6.09e-05	179	53	4	b35a7f8115c997c390201da01d7cb10b10769aec
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TAS2R8 DNAJC25 ABCA10 GABRA2	6.64e-05	183	53	4	2f0ee40e69ad1259e56e8ee4b352736900eb8901
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-secretory_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLK2 SGMS2 SLC50A1 SURF4	8.15e-05	193	53	4	64bcdbb422f8da6fc3275e82f6aaf562f546a180
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-secretory_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLK2 SLC50A1 ADGRG1 TMEM39A	8.15e-05	193	53	4	aaa5042388dc451bff384c6bb237348f08280a08
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLK2 SLC50A1 ADGRG1 TMEM39A	8.15e-05	193	53	4	4aee372ba2c0351b0221d0d468707d1ad21526d6
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SNED1 HAS1 HAS2 ABCA10	8.15e-05	193	53	4	261cafc167c86ab277be4ea7f08b0173e2dde26e
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLK2 SGMS2 SLC50A1 SURF4	8.15e-05	193	53	4	5a92697430f16c49e19a5f727d289d7bd1ece31c
ToppCell	(4)_Endothelial_cells-(42)_EC-sinusoidal\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	PLK2 LIPG ADGRG1 RAB20	8.32e-05	194	53	4	4428b472c2042f88eae028b1770767512a515b75
ToppCell	343B-Fibroblasts-Fibroblast-F\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SLC50A1 SURF4 DHCR7 HAS1	9.18e-05	199	53	4	08c7e631b2e203dd7dcb75a7f9377d292bc5a0fd
ToppCell	343B-Fibroblasts-Fibroblast-F-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SLC50A1 SURF4 DHCR7 HAS1	9.18e-05	199	53	4	4338bf6cafc26c5d6497955d91914f84bacfacfa
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Mesenchymal\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	ARSD SLC50A1 DNAJC25 PHTF1	9.36e-05	200	53	4	be83f442179ba4217d12f0458059586ff3130991
Computational	Genes in the cancer module 396.	GABRA2 GABRA3	3.38e-04	12	25	2	MODULE_396
Drug	Secobarbital	GRIA2 GABRA2 GABRA3	1.41e-06	10	53	3	DB00418
Drug	Metharbital	GRIA2 GABRA2 GABRA3	1.41e-06	10	53	3	DB00463
Drug	Pentobarbital	GRIA2 GABRA2 GABRA3	1.41e-06	10	53	3	DB00312
Drug	Talbutal	GRIA2 GABRA2 GABRA3	1.41e-06	10	53	3	DB00306
Drug	Butalbital	GRIA2 GABRA2 GABRA3	1.41e-06	10	53	3	DB00241
Drug	Butabarbital	GRIA2 GABRA2 GABRA3	1.41e-06	10	53	3	DB00237
Drug	Barbituric acid derivative	GRIA2 GABRA2 GABRA3	1.41e-06	10	53	3	DB01496
Drug	Barbital	GRIA2 GABRA2 GABRA3	1.41e-06	10	53	3	DB01483
Drug	Hexobarbital	GRIA2 GABRA2 GABRA3	1.41e-06	10	53	3	DB01355
Drug	Aprobarbital	GRIA2 GABRA2 GABRA3	1.41e-06	10	53	3	DB01352
Drug	Amobarbital	GRIA2 GABRA2 GABRA3	1.41e-06	10	53	3	DB01351
Drug	Heptabarbital	GRIA2 GABRA2 GABRA3	1.41e-06	10	53	3	DB01354
Drug	Butethal	GRIA2 GABRA2 GABRA3	1.41e-06	10	53	3	DB01353
Drug	Methylphenobarbital	GRIA2 GABRA2 GABRA3	1.41e-06	10	53	3	DB00849
Drug	Primidone	GRIA2 GABRA2 GABRA3	1.41e-06	10	53	3	DB00794
Drug	Thiopental	GRIA2 GABRA2 GABRA3	1.94e-06	11	53	3	DB00599
Drug	Phenobarbital	GRIA2 GABRA2 GABRA3	1.94e-06	11	53	3	DB01174
Drug	Zolpidem	GABRA2 GABRA3	1.59e-05	3	53	2	DB00425
Drug	Flumazenil	GABRA2 GABRA3	3.18e-05	4	53	2	DB01205
Drug	etizolam	GABRA2 GABRA3	3.18e-05	4	53	2	ctd:C044610
Drug	Eszopiclone	GABRA2 GABRA3	5.29e-05	5	53	2	DB00402
Drug	Quinidine barbiturate	GRIA2 GABRA2	5.29e-05	5	53	2	DB01346
Drug	Zopiclone	GABRA2 GABRA3	5.29e-05	5	53	2	DB01198
Drug	Lorazepam	GABRA2 GABRA3	5.29e-05	5	53	2	ctd:D008140
Drug	Tn 5	PTDSS1 PEX2 UROC1 HAS1 PHTF1	6.00e-05	179	53	5	CID006852148
Drug	picrotoxin	CLCN7 GRIA2 GABRA2 GABRA3 FARP2	6.33e-05	181	53	5	CID000031304
Drug	Meprobamate	GABRA2 GABRA3	7.93e-05	6	53	2	DB00371
Drug	Flunitrazepam	GABRA2 GABRA3	7.93e-05	6	53	2	DB01544
Drug	Tiletamine hydrochloride; Down 200; 15.4uM; MCF7; HT_HG-U133A	CLCN7 GRK6 ADGRG1 PTDSS2 GABRA2	8.36e-05	192	53	5	6013_DN
Drug	Cotinine (-) [486-56-6]; Down 200; 22.6uM; PC3; HG-U133A	PLK2 WWP1 NEMF HAS2 MICU2	8.36e-05	192	53	5	1929_DN
Drug	Paclitaxel [33069-62-4]; Down 200; 4.6uM; PC3; HG-U133A	WWP1 SUN1 NEMF PHTF2 TRAPPC10	9.22e-05	196	53	5	1959_DN
Drug	Quazepam	GABRA2 GABRA3	1.11e-04	7	53	2	DB01589
Drug	Adinazolam	GABRA2 GABRA3	1.48e-04	8	53	2	DB00546
Drug	Fludiazepam	GABRA2 GABRA3	1.48e-04	8	53	2	DB01567
Drug	Clotiazepam	GABRA2 GABRA3	1.48e-04	8	53	2	DB01559
Drug	Cinolazepam	GABRA2 GABRA3	1.48e-04	8	53	2	DB01594
Drug	Prazepam	GABRA2 GABRA3	1.48e-04	8	53	2	DB01588
Drug	Estazolam	GABRA2 GABRA3	1.48e-04	8	53	2	DB01215
Drug	Halazepam	GABRA2 GABRA3	1.48e-04	8	53	2	DB00801
Drug	1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane	GABRA2 GABRA3	1.48e-04	8	53	2	ctd:C091518
Drug	tiotidine	GABRA2 GABRA3	1.89e-04	9	53	2	ctd:C023990
Drug	Ethchlorvynol	GABRA2 GABRA3	1.89e-04	9	53	2	DB00189
Drug	Diazepam	GABRA2 GABRA3	1.89e-04	9	53	2	DB00829
Drug	Chlordiazepoxide	GABRA2 GABRA3	2.36e-04	10	53	2	DB00475
Drug	Clobazam	GABRA2 GABRA3	2.36e-04	10	53	2	DB00349
Drug	Bromazepam	GABRA2 GABRA3	2.36e-04	10	53	2	DB01558
Drug	Phosphatidylserine	PTDSS1 PTDSS2	2.36e-04	10	53	2	DB00144
Drug	R396	HRH4 TACR3	2.36e-04	10	53	2	CID000164286
Drug	Clonazepam	GABRA2 GABRA3	2.36e-04	10	53	2	DB01068
Drug	R 487	HRH4 TACR3	2.36e-04	10	53	2	CID000131469
Drug	Oxazepam	GABRA2 GABRA3	2.36e-04	10	53	2	DB00842
Drug	Midazolam	GABRA2 GABRA3	2.36e-04	10	53	2	DB00683
Drug	Flurazepam	GABRA2 GABRA3	2.36e-04	10	53	2	DB00690
Drug	pentylenetetrazol	GRIA2 HRH4 GABRA2 GABRA3	2.39e-04	130	53	4	CID000005917
Drug	oxazepam	HAS1 HAS2 GABRA2	2.57e-04	53	53	3	CID000004616
Drug	Alprazolam	GABRA2 GABRA3	2.89e-04	11	53	2	DB00404
Drug	Temazepam	GABRA2 GABRA3	2.89e-04	11	53	2	DB00231
Drug	Nitrazepam	GABRA2 GABRA3	2.89e-04	11	53	2	DB01595
Drug	Lorazepam	GABRA2 GABRA3	2.89e-04	11	53	2	DB00186
Drug	Musk T	HAS1 HAS2	2.89e-04	11	53	2	CID000061014
Drug	Triazolam	GABRA2 GABRA3	2.89e-04	11	53	2	DB00897
Drug	Clorazepate	GABRA2 GABRA3	2.89e-04	11	53	2	DB00628
Drug	NSC46155	HAS1 HAS2	3.46e-04	12	53	2	CID000457869
Drug	ketamine	DHCR7 GRIA2 ASIC5 GABRA2 GABRA3	3.55e-04	262	53	5	CID000003821
Disease	Autistic Disorder	DHCR7 GABRA2 GABRA3 FARP2	1.16e-03	261	52	4	C0004352
Disease	Cocaine-Related Disorders	GRIA2 TACR3 GABRA2	1.17e-03	117	52	3	C0236736
Disease	Cocaine Abuse	GRIA2 TACR3 GABRA2	1.48e-03	127	52	3	C0009171

Protein segments in the cluster

Peptide	Gene	Start	Entry
FISWYSSFGFVRRWN	ARSD	241	P51689
FIFRKWRKNNGFWSF	ABCA10	1036	Q8WWZ4
ANTTYRLQWWDFTKF	AMBRA1	856	Q9C0C7
VIDFFWNETWYLKTI	DHCR7	281	Q9UBM7
SFKWNFIKQYWQFAT	ANO3	581	Q9BYT9
FYLKQWRSYNISIWD	RAB20	41	Q9NX57
RFTYVLQDWQQYFWP	RAB3GAP1	231	Q15042
WFEKFLWFISSENYL	NEMF	526	O60524
YQNFRLNWAWISFEK	FREM2	1761	Q5SZK8
FATVNYFTKRGWAWD	GABRA2	331	P47869
ASFWNQFLTWRIFFA	CLCN7	316	P51798
WWFFTLIIISSYTAN	GRIA2	626	P42262
WVFLWRFTIYSKNAT	PEX2	61	P28328
QSWYNLWKEFRSYLS	LIPG	421	Q9Y5X9
FATVNYFTKRSWAWE	GABRA3	356	P34903
NTYFVLSSWWAKALF	DNAJC5	96	Q9H3Z4
WIPTFFSTQYFWFVL	DIO1	61	P49895
FSTQYFWFVLKVRWQ	DIO1	66	P49895
VFQFFSWWNSYNKAI	DNAJC25	161	Q9H1X3
QTRWSKSYFREWLYN	HAS2	351	Q92819
FDWNLQFKWDNVFSY	GALNTL5	276	Q7Z4T8
ITSFQGFLIFIWYWS	ADGRG1	646	Q9Y653
VTWQIYIRLLNYFTW	ASIC5	76	Q9NY37
WVSFLSSLRYWVAFN	HAS1	276	Q92839
QTRWSKSYFREWLYN	HAS1	376	Q92839
KRSWVWNQFFVLEEY	CDH7	46	Q9ULB5
SYFSQFLQWKWLERQ	GRK4	166	P32298
YLDSIYFNRFLQWKW	GRK6	161	P43250
WQKLWVVFTNFCLFF	FARP2	946	O94887
FSWTVYLWETFLAQR	ZMPSTE24	26	O75844
TRRFFNWFYWSINLG	SLC15A4	191	Q8N697
KSVWYRIAFWLQWFN	HRH4	336	Q9H3N8
LKQTFLSVFWQVRYW	TAS2R33	286	P0DSN6
FFPFFFRWWLQVTSK	PHTF2	121	Q8N3S3
IAFQFTPYSWVRFEW	PTDSS2	291	Q9BVG9
WLLFFTNTENKDIYW	MICU2	286	Q8IYU8
WLFAINVYFNAFWTI	SURF4	211	O15260
WWKTGIAFIYAVFNL	SGMS2	76	Q8NHU3
RAWWFPIFYFFEKNV	SGMS2	311	Q8NHU3
WKYIQQVYLASFWLA	TACR3	331	P29371
KVFFWALAWAINYRT	ABCC12	176	Q96J65
ATWVFVATWYRVTFF	SNED1	146	Q8TER0
FNFSWKVFTSWDYLI	TMC1	311	Q8TDI8
SFREWIRKFNWSSYN	TAS2R5	31	Q9NYW4
WIEQSVFRQWFEKYF	TIGD2	256	Q4W5G0
KTFLNDAYNWEFLIW	PHTF1	636	Q9UMS5
VFSNWAQFWLTMFYL	UROC1	131	Q96N76
ALFIQYINIYKTVWW	TMEM39A	86	Q9NV64
VTSFIRFWLFWKYPQ	SLC50A1	196	Q9BRV3
QARWFWEAYFQSIKA	EXT2	391	Q93063
FTFWTFANYLNMWIT	TAS2R8	86	Q9NYW2
GWYQFVTLISWLNVF	SUN1	266	O94901
QLSTSFQWVTKWVDY	PLK2	496	Q9NYY3
IYSKQSVFFVWELKW	TRAPPC10	1001	P48553
YTRNSKQIIWFWQFV	WWP1	821	Q9H0M0
KQESAWIFRLWYSFD	SLC9A7	591	Q96T83
SWTYVRWFDPKSSFQ	PTDSS1	271	P48651