Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR1N2 OR1N1 EPHB4 VN1R4 FLT4 OR4Q2 OR6C2 CCR9 OR4M1 OR2W5P MRGPRX3 OR1C1 CLDN4 CLDN3 OR11H12 ACKR4 PTGER1 OR13J1

2.44e-0713536618GO:0004888
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR1N2 OR1N1 VN1R4 OR4Q2 OR6C2 CCR9 OR4M1 OR2W5P MRGPRX3 OR1C1 OR11H12 ACKR4 PTGER1 OR13J1

9.06e-078846614GO:0004930
GeneOntologyMolecularFunctionolfactory receptor activity

OR1N2 OR1N1 OR4Q2 OR6C2 OR4M1 OR2W5P OR1C1 OR11H12 OR13J1

1.17e-05431669GO:0004984
GeneOntologyBiologicalProcesssensory perception

OR1N2 OR1N1 VN1R4 CFH LHFPL4 OR4Q2 WFS1 OR6C2 LHFPL3 OR4M1 OR2W5P OR1C1 OR11H12 KCNIP3 OR13J1

1.99e-0610726915GO:0007600
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR1N2 OR1N1 OR4Q2 OR6C2 OR4M1 REG3G OR2W5P OR1C1 OR11H12 OR13J1

9.11e-065246910GO:0009593
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR1N2 OR1N1 VN1R4 OR4Q2 OR6C2 OR4M1 OR2W5P OR1C1 OR11H12 OR13J1

1.32e-055476910GO:0007606
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR1N2 OR1N1 OR4Q2 OR6C2 OR4M1 OR2W5P OR1C1 OR11H12 OR13J1

1.33e-05432699GO:0050911
GeneOntologyBiologicalProcesssensory perception of smell

OR1N2 OR1N1 OR4Q2 OR6C2 OR4M1 OR2W5P OR1C1 OR11H12 OR13J1

2.38e-05465699GO:0007608
GeneOntologyBiologicalProcessregulation of exocyst localization

RALGAPB RALGAPA2

3.30e-053692GO:0060178
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR1N2 OR1N1 OR4Q2 OR6C2 OR4M1 OR2W5P OR1C1 OR11H12 OR13J1

3.31e-05485699GO:0050907
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR1N2 OR1N1 OR4Q2 OR6C2 OR4M1 OR2W5P OR1C1 OR11H12 OR13J1

1.34e-04582699GO:0050906
GeneOntologyBiologicalProcessdetection of stimulus

OR1N2 OR1N1 OR4Q2 OR6C2 OR4M1 REG3G OR2W5P OR1C1 OR11H12 OR13J1

1.37e-047226910GO:0051606
GeneOntologyBiologicalProcessRal protein signal transduction

RALGAPB RALGAPA2

1.64e-046692GO:0032484
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR1N2 OR1N1 VN1R4 OR4Q2 OR6C2 CCR9 OR4M1 OR2W5P MRGPRX3 OR1C1 OR11H12 ACKR4 PTGER1 OR13J1

1.80e-0413956914GO:0007186
GeneOntologyBiologicalProcessexocyst localization

RALGAPB RALGAPA2

3.05e-048692GO:0051601
GeneOntologyBiologicalProcesspositive regulation of metallopeptidase activity

CLDN4 CLDN3

3.91e-049692GO:1905050
GeneOntologyBiologicalProcessadaptive immune response

CFH ERCC1 TRBV17 TRBV13 TRBV11-3 IGHV1-69-2 TRBV6-5 TRBV6-4 LY9 CLCF1

4.50e-048386910GO:0002250
GeneOntologyCellularComponentT cell receptor complex

TRBV17 TRBV13 TRBV11-3 TRBV6-5 TRBV6-4

2.33e-04163715GO:0042101
GeneOntologyCellularComponentplasma membrane protein complex

CATSPERE TRBV17 TRBV13 TRBV11-3 NOX5 TRBV6-5 TRBV6-4 KCNIP3 ATP4A ABCG8

3.06e-047857110GO:0098797
GeneOntologyCellularComponentreceptor complex

EPHB4 FLT4 TRBV17 TRBV13 TRBV11-3 TRBV6-5 TRBV6-4 ABCG8

7.75e-04581718GO:0043235
MousePhenoabnormal postsynaptic density morphology

LHFPL4 TMEM59 KNDC1

5.61e-0527393MP:0020551
MousePhenoabnormal asymmetric synapse morphology

LHFPL4 TMEM59 KNDC1

6.27e-0528393MP:0020360
DomainGPCR_Rhodpsn_7TM

OR1N2 OR1N1 VN1R4 OR6C2 CCR9 OR4M1 OR2W5P MRGPRX3 OR1C1 OR11H12 ACKR4 PTGER1 OR13J1

3.53e-076706413IPR017452
DomainG_PROTEIN_RECEP_F1_1

OR1N2 OR1N1 VN1R4 OR6C2 CCR9 OR4M1 OR2W5P MRGPRX3 OR1C1 OR11H12 ACKR4 PTGER1 OR13J1

4.54e-076856413PS00237
DomainG_PROTEIN_RECEP_F1_2

OR1N2 OR1N1 VN1R4 OR6C2 CCR9 OR4M1 OR2W5P MRGPRX3 OR1C1 OR11H12 ACKR4 PTGER1 OR13J1

5.01e-076916413PS50262
DomainGPCR_Rhodpsn

OR1N2 OR1N1 VN1R4 OR6C2 CCR9 OR4M1 OR2W5P MRGPRX3 OR1C1 OR11H12 ACKR4 PTGER1 OR13J1

5.09e-076926413IPR000276
Domain7tm_1

OR1N2 OR1N1 OR6C2 CCR9 OR4M1 OR2W5P MRGPRX3 OR1C1 OR11H12 ACKR4 PTGER1 OR13J1

2.72e-066776412PF00001
DomainBSMAP

TMEM59 TMEM59L

1.16e-052642PF12280
DomainUncharacterised_TMEM59

TMEM59 TMEM59L

1.16e-052642IPR022065
DomainOlfact_rcpt

OR1N2 OR1N1 OR6C2 OR4M1 OR2W5P OR1C1 OR11H12 OR13J1

5.66e-05393648IPR000725
DomainLipome_HGMIC_fus_partner-like

LHFPL4 LHFPL3

2.40e-047642IPR019372
DomainL_HMGIC_fpl

LHFPL4 LHFPL3

2.40e-047642PF10242
DomainRap_GAP_dom

RALGAPB RALGAPA2

6.23e-0411642IPR000331
DomainRAPGAP

RALGAPB RALGAPA2

6.23e-0411642PS50085
DomainChemokine_rcpt

CCR9 ACKR4

1.34e-0316642IPR000355
DomainIg-like_dom

FLT4 CADM4 ZPBP2 KIRREL2 LY9 CD96 TMEM81

1.63e-03503647IPR007110
Domain-

EPHB4 FLT4 CADM4 ZPBP2 KIRREL2 LY9 CD96 TMEM81

1.85e-036636482.60.40.10
Domain4_helix_cytokine-like_core

IL11 HSP90B1 CLCF1

2.09e-0374643IPR009079
DomainClaudin_CS

CLDN4 CLDN3

2.55e-0322642IPR017974
DomainCLAUDIN

CLDN4 CLDN3

2.55e-0322642PS01346
DomainIg-like_fold

EPHB4 FLT4 CADM4 ZPBP2 KIRREL2 LY9 CD96 TMEM81

2.74e-03706648IPR013783
DomainIG

FLT4 CADM4 KIRREL2 LY9 CD96 TMEM81

3.15e-03421646SM00409
DomainIg_sub

FLT4 CADM4 KIRREL2 LY9 CD96 TMEM81

3.15e-03421646IPR003599
DomainEF-hand_5

NOX5 SDF4

3.30e-0325642PF13202
DomainClaudin

CLDN4 CLDN3

4.13e-0328642IPR006187
Domain-

ATP10A ATP4A

5.37e-03326422.70.150.10
Domain-

ATP10A ATP4A

5.37e-03326423.40.1110.10
DomainATPase_P-typ_cyto_domN

ATP10A ATP4A

6.39e-0335642IPR023299
DomainIG_LIKE

FLT4 CADM4 KIRREL2 LY9 CD96 TMEM81

6.62e-03491646PS50835
DomainATPase_P-typ_P_site

ATP10A ATP4A

6.76e-0336642IPR018303
DomainP_typ_ATPase

ATP10A ATP4A

6.76e-0336642IPR001757
DomainATPASE_E1_E2

ATP10A ATP4A

6.76e-0336642PS00154
DomainATPase_P-typ_transduc_dom_A

ATP10A ATP4A

7.13e-0337642IPR008250
DomainE1-E2_ATPase

ATP10A ATP4A

7.13e-0337642PF00122
DomainPMP22_Claudin

CLDN4 CLDN3

8.29e-0340642PF00822
DomainC2-set_2

CADM4 KIRREL2

8.70e-0341642PF08205
DomainCD80_C2-set

CADM4 KIRREL2

8.70e-0341642IPR013162
DomainPMP22/EMP/MP20/Claudin

CLDN4 CLDN3

1.04e-0245642IPR004031
Domain-

NOX5 SPOCK3 SDF4 KCNIP3

1.23e-022616441.10.238.10
Domain-

IL11 CLCF1

1.27e-02506421.20.1250.10
Domain4_helix_cytokine_core

IL11 CLCF1

1.32e-0251642IPR012351
Pubmed

The complete 685-kilobase DNA sequence of the human beta T cell receptor locus.

TRBV17 TRBV13 TRBV11-3 TRBV6-5 TRBV6-4

1.66e-06957258650574
Pubmed

Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications.

CLDN4 CLDN3

4.23e-06272220053926
Pubmed

Claudins overexpression in ovarian cancer: potential targets for Clostridium Perfringens Enterotoxin (CPE) based diagnosis and therapy.

CLDN4 CLDN3

4.23e-06272223685873
Pubmed

Differences in expression patterns of the tight junction proteins,claudin 1, 3, 4 and 5, in human ovarian surface epithelium as compared to epithelia in inclusion cysts and epithelial ovarian tumours.

CLDN4 CLDN3

4.23e-06272216287068
Pubmed

Comparison of claudin-3 and claudin-4 expression in bilateral and unilateral breast cancer.

CLDN4 CLDN3

4.23e-06272233147053
Pubmed

Claudin-3 and claudin-4 regulate sensitivity to cisplatin by controlling expression of the copper and cisplatin influx transporter CTR1.

CLDN4 CLDN3

4.23e-06272223053666
Pubmed

Involvement of claudin 3 and claudin 4 in idiopathic infantile hypercalcaemia: a novel hypothesis?

CLDN4 CLDN3

4.23e-06272220466674
Pubmed

Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3/-4 protein suggests structural modifications of the toxin to target specific claudins.

CLDN4 CLDN3

4.23e-06272222128179
Pubmed

Distinct behavior of claudin-3 and -4 around lactation period in mammary alveolus in mice.

CLDN4 CLDN3

4.23e-06272221912970
Pubmed

Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity.

CLDN4 CLDN3

4.23e-06272216103090
Pubmed

Claudin-3 and claudin-4 expression in serous papillary, clear-cell, and endometrioid endometrial cancer.

CLDN4 CLDN3

4.23e-06272218313739
Pubmed

Overexpression of claudin-3 and claudin-4 receptors in uterine serous papillary carcinoma: novel targets for a type-specific therapy using Clostridium perfringens enterotoxin (CPE).

CLDN4 CLDN3

4.23e-06272217326053
Pubmed

Adipocytes contain a novel complex similar to the tuberous sclerosis complex.

RALGAPB RALGAPA2

4.23e-06272216490346
Pubmed

Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo.

CLDN4 CLDN3

4.23e-0627229334247
Pubmed

Prognostic significance of intestinal claudins in high-risk synchronous and metachronous multiple gastric epithelial neoplasias after initial endoscopic submucosal dissection.

CLDN4 CLDN3

4.23e-06272218477216
Pubmed

Oxidative stress induces gastric epithelial permeability through claudin-3.

CLDN4 CLDN3

4.23e-06272218774778
Pubmed

Overexpression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in uterine carcinosarcomas.

CLDN4 CLDN3

4.23e-06272217545541
Pubmed

Altered expression of claudin-3 and claudin-4 in ectopic endometrium of women with endometriosis.

CLDN4 CLDN3

4.23e-06272218384777
Pubmed

Claudin 13, a member of the claudin family regulated in mouse stress induced erythropoiesis.

CLDN4 CLDN3

4.23e-06272220844758
Pubmed

Tight junction proteins claudin-3 and claudin-4 control tumor growth and metastases.

CLDN4 CLDN3

4.23e-06272223097631
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR1N2 OR1N1 OR4Q2 OR2W5P OR1C1 OR13J1

6.43e-0621972612213199
Pubmed

Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases.

RALGAPB RALGAPA2

1.27e-05372219520869
Pubmed

[The expression of claudins in colonic neoplasms].

CLDN4 CLDN3

1.27e-05372228295005
Pubmed

The degradation of airway tight junction protein under acidic conditions is probably mediated by transient receptor potential vanilloid 1 receptor.

CLDN4 CLDN3

1.27e-05372224073800
Pubmed

All Benign and Malignant Apocrine Breast Lesions Over-Express Claudin 1 and 3 and Are Negative for Claudin 4.

CLDN4 CLDN3

1.27e-05372231044387
Pubmed

Gastric and intestinal claudin expression at the invasive front of gastric carcinoma.

CLDN4 CLDN3

1.27e-05372217459057
Pubmed

The expression patterns of tight junction protein claudin-1, -3, and -4 in human gastric neoplasms and adjacent non-neoplastic tissues.

CLDN4 CLDN3

1.27e-05372225755790
Pubmed

Cdx2 transcription factor regulates claudin-3 and claudin-4 expression during intestinal differentiation of gastric carcinoma.

CLDN4 CLDN3

1.27e-05372218251778
Pubmed

Claudins upregulation in human colorectal cancer.

CLDN4 CLDN3

1.27e-05372216253248
Pubmed

Valproate, a mood stabilizer, induces WFS1 expression and modulates its interaction with ER stress protein GRP94.

HSP90B1 WFS1

1.27e-05372219125190
Pubmed

Claudin-1, -3 and -4 proteins and mRNA expression in benign and malignant breast lesions: a research study.

CLDN4 CLDN3

1.27e-05372215743508
Pubmed

Role of regenerating gene I in claudin expression and barrier function in the small intestine.

CLDN4 CLDN3

2.53e-05472227055226
Pubmed

Claudin expression in rectal well-differentiated endocrine neoplasms (carcinoid tumors).

CLDN4 CLDN3

2.53e-05472219082451
Pubmed

Claudin expression profiles in Epstein-Barr virus-associated nasopharyngeal carcinoma.

CLDN4 CLDN3

2.53e-05472220204275
Pubmed

Diagnostic utility of expression of claudins in non-small cell lung cancer: different expression profiles in squamous cell carcinomas and adenocarcinomas.

CLDN4 CLDN3

2.53e-05472219231096
Pubmed

Expression of tight and adherens junction proteins in ulcerative colitis associated colorectal carcinoma: upregulation of claudin-1, claudin-3, claudin-4, and beta-catenin.

CLDN4 CLDN3

2.53e-05472219184060
Pubmed

Grainyhead-like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25.

CLDN4 CLDN3

2.53e-05472222696678
Pubmed

Differential expression of claudin family proteins in mouse ovarian serous papillary epithelial adenoma in aging FSH receptor-deficient mutants.

CLDN4 CLDN3

4.21e-05572217217615
Pubmed

Distinct claudin expression profile in histologic subtypes of lung cancer.

CLDN4 CLDN3

4.21e-05572217418912
Pubmed

Expression of occludin and claudins 1, 3, 4, and 7 in urothelial carcinoma of the upper urinary tract.

CLDN4 CLDN3

4.21e-05572218550469
Pubmed

Androgen-dependent sertoli cell tight junction remodeling is mediated by multiple tight junction components.

CLDN4 CLDN3

4.21e-05572224825397
Pubmed

Divergent expression of claudin -1, -3, -4, -5 and -7 in developing human lung.

CLDN4 CLDN3

4.21e-05572220478039
Pubmed

Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins.

CLDN4 CLDN3

4.21e-05572215070779
Pubmed

Initiation and developmental dynamics of Wfs1 expression in the context of neural differentiation and ER stress in mouse forebrain.

HSP90B1 WFS1

6.31e-05672224694561
Pubmed

Novel function of LHFPL2 in female and male distal reproductive tract development.

LHFPL4 LHFPL3

8.82e-05772226964900
Pubmed

Nucleotide sequence analysis of 77.7 kb of the human V beta T-cell receptor gene locus: direct primer-walking using cosmid template DNAs.

TRBV17 TRBV13

8.82e-0577228020962
Pubmed

Genes for the CPE receptor (CPETR1) and the human homolog of RVP1 (CPETR2) are localized within the Williams-Beuren syndrome deletion.

CLDN4 CLDN3

8.82e-0577229878248
Pubmed

Endothelial RAF1/ERK activation regulates arterial morphogenesis.

EPHB4 FLT4

8.82e-05772223529931
Pubmed

A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action.

RALGAPB RALGAPA2

8.82e-05772221148297
Pubmed

HIV-1 Tat protein alter the tight junction integrity and function of retinal pigment epithelium: an in vitro study.

CLDN4 CLDN3

8.82e-05772218538010
Pubmed

Molecular identification of venous progenitors in the dorsal aorta reveals an aortic origin for the cardinal vein in mammals.

EPHB4 FLT4

1.17e-04872224550118
Pubmed

Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands.

CLDN4 CLDN3

1.17e-0487229892664
Pubmed

Mouse alloantigen system Ly-m22 predominantly expressed on T lymphocytes and controlled by a gene linked to M1s region on chromosome 1.

CFH LY9

1.17e-0487226332054
Pubmed

Claudins in human cancer: a review.

CLDN4 CLDN3

1.17e-04872219924644
Pubmed

Cdx2 determines the fate of postnatal intestinal endoderm.

MUC6 ATP4A

1.17e-04872222190642
Pubmed

Chromosome mapping of Rmp-4, a gonad-dependent gene encoding host resistance to mousepox.

CFH LY9

1.17e-0487227474114
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

EPHB4 THADA TM9SF2 USO1 WFS1 RPTOR TMEM59 SCAMP3 URB2

1.40e-0494272931073040
Pubmed

HIV-1 impairs human retinal pigment epithelial barrier function: possible association with the pathogenesis of HIV-associated retinopathy.

CLDN4 CLDN3

1.51e-04972224840331
Pubmed

PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature.

EPHB4 FLT4

1.51e-04972215687262
Pubmed

Specific cytokines of interleukin-6 family interact with S100 proteins.

IL11 CLCF1

1.51e-04972234933172
Pubmed

Altered Maturation of Medullary TEC in EphB-Deficient Thymi Is Recovered by RANK Signaling Stimulation.

CLDN4 CLDN3

1.51e-04972229867988
Pubmed

Developmental changes in the expression of tight junction protein claudins in murine metanephroi and embryonic kidneys.

CLDN4 CLDN3

1.88e-041072216520537
Pubmed

claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing.

CLDN4 CLDN3

1.88e-041072211585919
Pubmed

Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development.

EPHB4 FLT4

1.88e-041072210323857
Pubmed

Tight junction proteins at the blood-brain barrier: far more than claudin-5.

CLDN4 CLDN3

1.88e-041072230734065
Pubmed

Permeability barrier dysfunction in transgenic mice overexpressing claudin 6.

CLDN4 CLDN3

1.88e-041072211923212
Pubmed

Reduced mTORC1-signaling in retinal ganglion cells leads to vascular retinopathy.

FLT4 RPTOR

2.30e-041172234148274
Pubmed

The genomic structure of human V beta 6 T cell antigen receptor genes.

TRBV11-3 TRBV6-4

2.30e-04117221660526
Pubmed

Expression of claudins in murine tooth development.

CLDN4 CLDN3

2.30e-041172217075866
Pubmed

A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice.

LHFPL4 LHFPL3

2.75e-041272215905332
Pubmed

Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins.

CLDN4 CLDN3

2.75e-041272210601346
Pubmed

Proneurogenic Ligands Defined by Modeling Developing Cortex Growth Factor Communication Networks.

NRTN CLCF1

2.75e-041272227545711
Pubmed

Further mapping and characterization of Naq1, a quantitative trait locus responsible for maternal inferior nurturing ability in RR mice.

CLDN4 CLDN3

2.75e-041272215472464
Pubmed

Lessons from thymic epithelial heterogeneity: FoxN1 and tissue-restricted gene expression by extrathymic, endodermally derived epithelium.

CLDN4 CLDN3

2.75e-041272219786540
Pubmed

Canonical and Non-Canonical Localization of Tight Junction Proteins during Early Murine Cranial Development.

CLDN4 CLDN3

2.75e-041272238338705
Pubmed

CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family.

CLDN4 CLDN3

2.75e-041272212736707
Pubmed

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.

CADM4 KIRREL2 LY9 TMEM81

3.65e-0416272425826454
Pubmed

Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function.

THADA WFS1

3.78e-041472219833888
Pubmed

ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes.

ERCC1 ATP10A

3.78e-041472228368372
Pubmed

Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.

CFH URB2

3.78e-041472223620142
Pubmed

Expression patterns of claudin family of tight junction membrane proteins in developing mouse submandibular gland.

CLDN4 CLDN3

3.78e-041472215366020
Pubmed

FoxN1 mediates thymic cortex-medulla differentiation through modifying a developmental pattern based on epithelial tubulogenesis.

CLDN4 CLDN3

4.36e-041572231552487
Pubmed

NOTCH1 signaling establishes the medullary thymic epithelial cell progenitor pool during mouse fetal development.

CLDN4 CLDN3

4.36e-041572232467240
Pubmed

Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis.

CLDN4 CLDN3

4.98e-041672225053428
Pubmed

Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2.

EPHB4 FLT4

4.98e-041672226027726
Pubmed

Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and Connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout mice.

EPHB4 FLT4

4.98e-041672226953188
Pubmed

The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.

CLDN4 CLDN3

5.63e-041772218799149
Pubmed

Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.

THADA WFS1

5.63e-041772219741467
Pubmed

Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2.

CLDN4 CLDN3

5.63e-041772231171776
Pubmed

Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.

THADA WFS1

5.63e-041772219502414
Pubmed

The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development.

EPHB4 FLT4

6.33e-041872216678147
Pubmed

Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.

THADA WFS1

6.33e-041872219324937
Pubmed

Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice.

EPHB4 FLT4

6.33e-041872219644017
Pubmed

Clinical risk factors, DNA variants, and the development of type 2 diabetes.

THADA WFS1

7.06e-041972219020324
Pubmed

The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling.

EPHB4 FLT4

7.06e-041972220627076
Pubmed

Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function.

CLDN4 CLDN3

7.06e-041972222155109
Pubmed

Coronary arteries form by developmental reprogramming of venous cells.

EPHB4 FLT4

7.06e-041972220336138
Pubmed

Biology of claudins.

CLDN4 CLDN3

7.06e-041972218480174
Pubmed

Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study.

THADA WFS1

7.06e-041972219139842
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR1N2 OR1N1 OR6C2 OR4M1 OR13J1

7.10e-0434072511875048
Cytoband7q34

TRBV17 TRBV13 TRBV11-3 TRBV6-5 TRBV6-4

6.89e-061677257q34
CytobandEnsembl 112 genes in cytogenetic band chr7q34

TRBV17 TRBV13 TRBV11-3 TRBV6-5 TRBV6-4

1.13e-05185725chr7q34
Cytoband14q11.2

OR4Q2 OR4M1 OR11H12 METTL17

1.91e-0418072414q11.2
Cytoband1q44

CATSPERE OR2W5P OR1C1

7.08e-041107231q44
CytobandEnsembl 112 genes in cytogenetic band chr1q44

CATSPERE OR2W5P OR1C1

1.10e-03128723chr1q44
Cytoband9q33.2

OR1N2 OR1N1

1.73e-03397229q33.2
CytobandEnsembl 112 genes in cytogenetic band chr14q11

OR4Q2 OR4M1 OR11H12 METTL17

1.88e-03332724chr14q11
Cytoband2p21

THADA ABCG8

4.18e-03617222p21
GeneFamilyImmunoglobulin like domain containing

FLT4 CADM4 ZPBP2 KIRREL2 LY9 CD96 TMEM81

1.86e-06193557594
GeneFamilyT cell receptor beta locus at 7q34

TRBV17 TRBV13 TRBV11-3 TRBV6-5 TRBV6-4

6.61e-0687555372
GeneFamilyInterleukin 6 cytokine family

IL11 CLCF1

1.89e-0475521264
GeneFamilyOlfactory receptors, family 1

OR1N2 OR1N1 OR1C1

2.43e-0440553147
GeneFamilyClaudins

CLDN4 CLDN3

2.21e-0323552488
ToppCelldroplet-Lung-LUNG-30m-Epithelial-club_cell_of_bronchiole|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

B3GNT4 NRTN KNDC1 REG3G CLDN4 CLDN3

3.95e-071777167ac99ff16df94b4e08d361e3d98a7b3af8d6ee3b
ToppCelldroplet-Lung-LUNG-30m-Epithelial-Club_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

B3GNT4 NRTN KNDC1 REG3G CLDN4 CLDN3

3.95e-07177716092a345cb802f183322aa5542341ba2d96d4f06a
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-BM_CD8_+_CD4_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THADA CPLANE1 ATP10A CD96 TMEM81

5.75e-0616071555f599df6e3b7a5a505df4b094c834281311d94a
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-mature_alpha-beta_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THADA CPLANE1 ATP10A CD96 TMEM81

5.75e-06160715296e53e1e0786346d38db2d4188b9a1c0430627b
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPRY4 LHFPL3 TMEM59L CES4A KCNIP3

1.05e-051817151037051eb82313c13346617b33f3c4c648181c4d
ToppCellSevere-MAIT|World / Disease group and Cell class

CFH FLT4 TRBV6-4 LY9 CD96

1.32e-051907157a92e0d6a021be23125495927b8571e25c83204a
ToppCellSevere-MAIT|Severe / Disease group and Cell class

CFH FLT4 TRBV6-4 LY9 CD96

1.32e-051907151c063dc1b62d9f9912aaf8d0297555a6545f5550
ToppCellBronchial-10x5prime-Immune_Lymphocytic-T-T_CD4-CD4|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TRBV11-3 TRBV6-5 TRBV6-4 LY9 CD96

1.58e-051977154bc76958ca12af2dd490d4865de6a92554a14656
ToppCellTCGA-Thymus|World / Sample_Type by Project: Shred V9

TRBV13 TRBV11-3 CCR9 TRBV6-4

4.78e-05125714109857418118020d35f05a5eb8a25bb7e3d8ed2a
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRBV17 CCR9 ZPBP2 CD96

1.21e-041597148d958d79f5eb3ab683d1245ae7f4f22a2cefbc55
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CFH SLC22A11 CLCF1 ATP10A

1.21e-041597149f6607e395bcca9cb1c83199bdbbaaa62a93938d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CFH SLC22A11 CLCF1 ATP10A

1.21e-04159714c8b42ebc25ebcc450832096fbffaa5c5f5fe88e7
ToppCelldroplet-Heart-nan-24m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH SPRY4 SDF4 KCNIP3

1.27e-04161714eb546d5065ac506405d240f9a1f55f2122d0c368
ToppCellwk_20-22-Hematologic_Lymphocytic-T_&_ILC-T_entry|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

TRBV13 RPTOR CCR9 TRBV6-4

1.30e-04162714a27750117e7f16a0bd07cc5f58a56becb39e800b
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-Trm_Th1/Th17|bone_marrow / Manually curated celltypes from each tissue

CCR9 KIRREL2 MUC6 CD96

1.34e-041637144d1fd0b1246833723b938eca0cb246e937380e12
ToppCellBAL-Mild-Lymphocyte-T/NK-CD8+_T-MAIT-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FLT4 CCR9 TRBV6-4 CD96

1.43e-04166714bb93db4613c067c56614ab1ca39e73ee46484387
ToppCellBAL-Mild-Lymphocyte-T/NK-CD8+_T-MAIT|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FLT4 CCR9 TRBV6-4 CD96

1.43e-04166714c1f17a028bb27b8f202bcfffa7de7373b1cdd990
ToppCell5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.4|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SPOCK3 TMEM59L CLDN4 KIRREL2

1.53e-04169714d59c8cd0719ed0947d42da9e7e5da72ff58ecc0d
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRBV17 CCR9 LY9 CD96

1.60e-04171714801893c318f7b1abc8d97bac86a00974f910a71c
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

IL11 CLDN4 CLDN3 CLCF1

1.64e-04172714bd73fd3520064d430a153cfdd5c2858b6c184c59
ToppCell5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH SPOCK3 TMEM59L CLDN4

1.64e-04172714bd01b39a5699824ab14827cc9dc98e547d65b160
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

IL11 CLDN4 CLDN3 CLCF1

1.64e-0417271447ee78ed3ba6516dad8f12dbf70bca5ed1c60aff
ToppCelldroplet-Lung-21m-Epithelial-airway_epithelial|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

B3GNT4 KNDC1 CLDN4 CLDN3

1.68e-04173714a809be2630d2b91b53b82b5e2bb99e05524597c1
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZPBP2 CLDN4 CLDN3 LY9

1.68e-041737147c5e4809205ce1a0a301c15442af00a2e2b9b301
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_4|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

EPHB4 SPRY4 CLDN3 PTGER1

1.68e-04173714ef8d720b99470fe1953661f6e66bc0366266bdb6
ToppCell5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH SPOCK3 TMEM59L CLDN4

1.72e-04174714911eac6f6ec1e5e85348a7fe774243498388a810
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EPHB4 FLT4 WFS1 SPOCK3

1.75e-0417571443be63976da5ad0764d24d90919a77ce46068f52
ToppCell10x5'-Lung-Lymphocytic_Invariant-Inducer-like-MAIT|Lung / Manually curated celltypes from each tissue

CFH FLT4 TRBV6-4 LY9

1.75e-04175714f6663e5a9c87e27f3459a6481768b03aff7d0855
ToppCell10x5'-blood-Lymphocytic_Invariant-Inducer-like-MAIT|blood / Manually curated celltypes from each tissue

CFH FLT4 TRBV6-5 TRBV6-4

1.75e-04175714b4e4b66e89f79999768a6192c8404cb2465f920b
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRBV17 CCR9 LY9 CD96

1.83e-04177714c840efec4eba746543eac0f48dd688518f0fb5f0
ToppCell10x5'-Lung-Lymphocytic_Invariant-Inducer-like|Lung / Manually curated celltypes from each tissue

CFH FLT4 TRBV6-4 CD96

1.87e-04178714bb5dc22f6bcde1ce29598ae4e839e98a7caa07b6
ToppCellAdult-Epithelial-club_cell-D122|Adult / Lineage, Cell type, age group and donor

CFH OR6C2 CLDN4 KCNIP3

1.87e-0417871435a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CFH TRBV17 TRBV6-5 CD96

1.95e-0418071405f14cd367021891166825a8aac171227e2bcd97
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRTN CLDN4 CLDN3 ACKR4

1.99e-04181714a5e770b5b5d57cbac18560828e89f7c96b687743
ToppCellfacs-Heart-RA-24m-Myeloid-macrophage|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CADM4 REG3G CLDN4 CLCF1

1.99e-04181714c68d272eb41f81bd8ea4d0360733a2396bc87037
ToppCellfacs-Heart-RA-24m-Myeloid-macrophage|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CADM4 REG3G CLDN4 CLCF1

1.99e-041817145e5eb89f224ee48065a328ade030cbc4dcdcac12
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRTN CLDN4 CLDN3 ACKR4

1.99e-04181714504b1af1951a7a20ef5db69d84c20630ec64095b
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRTN CLDN4 CLDN3 ACKR4

1.99e-04181714a55ec36d2393f7a376feb42b22aee75dfdf4c383
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL11 SPOCK3 CCR9 CLDN4

1.99e-041817147af469f5bcb9b1ab3f35b2758bf2afb87e8eba57
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLDN4 CLDN3 ACKR4 CLCF1

2.04e-041827149174fb0b7ed8f721a5c513e41fd80476a9f34332
ToppCellmetastatic_Lymph_Node-B_lymphocytes-Plasma_cells|B_lymphocytes / Location, Cell class and cell subclass

HSP90B1 IGHV1-69-2 TMEM59 MUC6

2.04e-0418271427d1688fdfc570cedd233aa7030bce7d9b604d42
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-TA|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

REG3G CLDN4 CLDN3 MUC6

2.08e-041837140d21befacefc6c597e7b501ed41b7fe9385a78df
ToppCell5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLT4 WFS1 RALGAPA2 ACKR4

2.08e-041837142d0d3b486498a7903fa9a1f48b189291da49c430
ToppCell368C-Lymphocytic-Plasma_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

HSP90B1 USO1 WFS1 CLDN3

2.08e-041837147733cf919eda146efe41c93990658ce92db73aa8
ToppCell368C-Lymphocytic-Plasma_cell-|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

HSP90B1 USO1 WFS1 CLDN3

2.08e-04183714d91441cbf94f5c3b7c36f2ca3a46895870bd730f
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NRTN CLDN4 CLDN3 MUC6

2.08e-04183714263937906ddabc798bbe60f0da28ba859a5c72e2
ToppCellPCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC-im_ILC3_(12)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CCR9 LY9 ATP10A CD96

2.12e-041847143e9d75af578297950e469f23fb2d28393a2feef8
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLT4 SPOCK3 KCNIP3 RALGAPA2

2.12e-0418471430ca56d64c961127e26122613e35aa2b46fde2df
ToppCelldroplet-Liver-Hepatocytes-24m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT4 MTERF2 SPRY4 ACKR4

2.21e-041867142cae34336f184f971f7c8684cc27c23a4e7369ed
ToppCelldroplet-Liver-LIVER_HEP-30m-Lymphocytic-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM59L CLDN4 METTL17 TMEM81

2.21e-04186714f5468e03321ea2083e223eb0d92c3a9307039569
ToppCelldroplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT4 MTERF2 SPRY4 ACKR4

2.21e-0418671490d53c2597a9f3a2b39afba75adfc54f1ca0a4db
ToppCell10x5'v1-week_17-19-Lymphocytic_T-T_NK-NK_T_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

CCR9 CES4A LY9 CD96

2.26e-041877143301e0fca8c436d136c71f1a8fd59b3bb11bdd83
ToppCellfacs-Lung-EPCAM-24m-Epithelial-Club_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRTN REG3G CLDN4 CLDN3

2.26e-0418771474112df9b34051ae5cd2427ccfa3399eccff0076
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CFH FLT4 TRBV6-4 CD96

2.26e-04187714f1ba41f2ec703251a81c46e08d45e70210f298e7
ToppCellfacs-Lung-EPCAM-24m-Epithelial-club_cell_of_bronchiole|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRTN REG3G CLDN4 CLDN3

2.26e-04187714214ce9b55fd6ce2fe7bd4cf4b1383517f5f0d759
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPRY4 LHFPL3 TMEM59L KCNIP3

2.31e-04188714006db2c2c44971ca9241c582bc89f258c785f5ed
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPRY4 LHFPL3 TMEM59L KCNIP3

2.31e-04188714d0e6fb4a3b3d79d3512b5500062ea285495ae526
ToppCellPCW_13-14-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC-im_ILC3_(12)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CCR9 LY9 ATP10A CD96

2.35e-0418971478dcda09109a5cfb04ba069f16ec80987b3ad432
ToppCelldroplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT4 MTERF2 SPRY4 ACKR4

2.35e-04189714ce5b3d53c9a5457a5a02b221dee18334b5eaf8b7
ToppCell10x5'-bone_marrow-Lymphocytic_Invariant-Inducer-like|bone_marrow / Manually curated celltypes from each tissue

CFH FLT4 TRBV6-4 CD96

2.35e-04189714ac2995e599f3d1813218479dc515b1d612c0ef8b
ToppCell10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-MAIT|lymph-node_spleen / Manually curated celltypes from each tissue

CFH FLT4 TRBV6-4 CD96

2.35e-04189714afe3a4fe7c10eeeb7064129778d940269c9acbef
ToppCell5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCR9 LY9 ATP10A CD96

2.45e-041917141fde5b0cd2b85d4a4a6c71da8316ecd2fde676fa
ToppCell10x5'-bone_marrow-Lymphocytic_Invariant-Inducer-like-MAIT|bone_marrow / Manually curated celltypes from each tissue

CFH FLT4 TRBV6-4 CD96

2.45e-041917147a28905ad504979497836e87df81d529e675ce78
ToppCellPCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

TMEM59L CLDN4 CLDN3 CLCF1

2.50e-0419271439804d9ddc67c1b41887752df2503389eae44a1a
ToppCell10x5'v1-week_14-16-Lymphocytic_T-T_NK-NK_T_cell|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

TRBV13 CCR9 TRBV6-5 CD96

2.50e-04192714e836e3e4f419acdca106bc666c3c687f02da2fb3
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 FLT4 SPRY4 RALGAPA2

2.50e-041927142bfac6b3956265205ca47d06888851ed68b65999
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD8+_T-MAIT|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

CFH FLT4 ZSWIM4 CD96

2.50e-04192714892789bdba150ef9a8a0012de52545f2ff6a31f6
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD8+_T-MAIT-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CFH FLT4 ZSWIM4 CD96

2.50e-0419271424ea8fdcca2695aeb2e4b88161184124b7d332c1
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD8+_T-MAIT-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CFH FLT4 ZSWIM4 CD96

2.50e-0419271444f440ee3842fe14665c4cd4f2aa48e7a5bbd9a8
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD8+_T-MAIT|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CFH FLT4 ZSWIM4 CD96

2.50e-041927148d50ad8cfe3cb9f183188b08457756af0ce56ffe
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 FLT4 SPRY4 RALGAPA2

2.50e-04192714d525f7f088a53110912600a7c9f6d33b9270d534
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Epcam____kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPOCK3 CLDN4 PTGER1 ATP4A

2.55e-041937140208fcd8ea4662f40fc2c072ac220d97823eec12
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPOCK3 CLDN4 PTGER1 ATP4A

2.55e-0419371404d47ba7cc1f19f1ffb18d9e68469e75063697cf
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPOCK3 CLDN4 PTGER1 ATP4A

2.55e-041937140499611c21d283321ef6dd24add154dea48da1b7
ToppCell5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLT4 WFS1 SPOCK3 RALGAPA2

2.55e-04193714bd0027fa97de41ae22ff64a61c8e217496f122ca
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

IL11 NOX5 KCNIP3 PTGER1

2.55e-04193714e5016959f24370579a8770787e96869f264cf7b3
ToppCellBronchial-10x5prime-Immune_Lymphocytic-T-T_CD8-MAIT|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TRBV6-4 LY9 ATP4A CD96

2.55e-041937149aeb34d7a24f84abff38d7b8cf0ec707c08eb27f
ToppCellcellseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CFH CLDN4 CLDN3 MUC6

2.60e-041947145402835d6b252276e458001949dd1cb5aa744b0e
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 FLT4 SPRY4 RALGAPA2

2.60e-04194714c8b9551b93a5aed62154b487db90130604a6125c
ToppCellmetastatic_Brain-B_lymphocytes-Plasma_cells|B_lymphocytes / Location, Cell class and cell subclass

HSP90B1 TM9SF2 WFS1 TMEM59

2.60e-0419471469828d24b3e182f26aa15eb0ae5aa21c640c2922
ToppCellcellseq-Epithelial-Epithelial_Airway-Secretory/RAS|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CFH CLDN4 CLDN3 MUC6

2.60e-041947142c0236a102f7fec6d508afec6137da5b26a65931
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CLDN4 CLDN3 KCNIP3 CLCF1

2.60e-0419471470185c0b8e0f4e896645b17a243482ba3cdf4a5d
ToppCellnormal_Lymph_Node-B_lymphocytes-MALT_B_cells|B_lymphocytes / Location, Cell class and cell subclass

HSP90B1 WFS1 TMEM59 CLDN3

2.60e-041947141ca034f25a8fce503fb67654d7fa2a8ec71976be
ToppCellBAL-Severe-Lymphocyte-T/NK-CD8+_T-MAIT|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FLT4 TRBV6-4 LY9 CD96

2.65e-04195714caa3669739974b63470f7e557df96e8d3844dd84
ToppCellPCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TMEM59L CLDN4 CLDN3 CLCF1

2.65e-0419571462d369a8af2b76a2553bc8ff9cb89a133b060123
ToppCellBAL-Severe-Lymphocyte-T/NK-CD8+_T-MAIT-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FLT4 TRBV6-4 LY9 CD96

2.65e-04195714bc5728e9df0b15adec50a7c840ce9f2775135087
ToppCell11.5-Airway-Epithelial-Secretory_progenitor|Airway / Age, Tissue, Lineage and Cell class

CFH TMEM59L CLDN4 CLDN3

2.65e-041957148cbc78a6cb812f907c69b00f85263976216840ac
ToppCellfacs-Lung-nan-3m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 FLT4 TM9SF2 ACKR4

2.65e-041957147f9b7f15006610ad591063d90e90367bd6083c7f
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_basal-Basal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFH SPOCK3 TMEM59L CLDN4

2.70e-04196714c5adab88140a465698abcbedc6505a43cae7bfd1
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 FLT4 SPRY4 RALGAPA2

2.70e-0419671481900dcc9451ff6606ec940c16b559d73247590e
ToppCell11.5-Distal-Epithelial-Secretory_progenitor|Distal / Age, Tissue, Lineage and Cell class

CFH TMEM59L CLDN4 CLDN3

2.70e-041967142648d64b0e7b59ae78182d55f32699ceea37ff8d
ToppCell3'-GW_trimst-1-SmallIntestine-Hematopoietic-T_cells|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCR9 LY9 ATP10A CD96

2.70e-04196714609959609ab1870c562cefca0fd49e0d701d1e5b
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 FLT4 SPRY4 RALGAPA2

2.75e-04197714d584d0334ea97e3fa8c4cd869f5eeea2c7a1ed04
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH SMPDL3A TMEM59 CLCF1

2.75e-041977142e3d64648a1e4f01b9256a96b94b8a640ee1824c
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 FLT4 SPRY4 RALGAPA2

2.75e-04197714412091994196a06c2779b4c2cfed84be889a5f8d
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH SMPDL3A TMEM59 CLCF1

2.75e-04197714d9e196c8b4a6ede4733946dbdba3331534954beb
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM59 LHFPL3 CLDN4 CLDN3

2.75e-041977145a71e859ebe734fc70a056807b07d99fa867c687
ToppCell5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EPHB4 FLT4 WFS1 RALGAPA2

2.75e-04197714407231542fa1ffd540dcb61435c0575e71f59725
ToppCellB_cells-Plasmablasts|B_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

USO1 WFS1 TMEM59 SDF4

2.81e-04198714c6cab47885be74a64351f843a741dea6d911bde4
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-T-T_CD8-CD8_GZMK+|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TRBV13 TRBV6-5 LY9 CD96

2.86e-041997147642a6bc957ecb5953e966ba296b9f4deb368364
Diseaseautosomal recessive nonsyndromic deafness 67 (implicated_via_orthology)

LHFPL4 LHFPL3

1.14e-053582DOID:0110518 (implicated_via_orthology)
Diseaseleucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 measurement

CFH HSP90B1

2.27e-054582EFO_0802702
Diseaseobsolete_interleukin-1 alpha measurement

CFH REG3G

7.92e-057582EFO_0802653
Diseasedelta-5 desaturase measurement

LHFPL4 LHFPL3

2.06e-0411582EFO_0007764
DiseaseMammary Ductal Carcinoma

CLDN4 PTGER1

2.06e-0411582C0021367
DiseaseInvasive Ductal Breast Carcinoma

CLDN4 PTGER1

2.06e-0411582C1134719
Diseasepeptic esophagitis (biomarker_via_orthology)

CLDN4 CLDN3

2.47e-0412582DOID:13976 (biomarker_via_orthology)
Diseasegastric ulcer (implicated_via_orthology)

PTGER1 MUC6

3.40e-0414582DOID:10808 (implicated_via_orthology)
Diseasedelta-6 desaturase measurement

LHFPL4 LHFPL3

3.92e-0415582EFO_0007765
DiseaseIntrahepatic cholestasis of pregnancy

ATP4A ABCG8

4.48e-0416582EFO_0009048
DiseaseSLAM family member 7 measurement

CFH LY9

5.07e-0417582EFO_0008287
Diseasemyeloperoxidase measurement

CFH THADA

1.20e-0326582EFO_0005243
Diseasedihomo-gamma-linolenic acid measurement

LHFPL4 LHFPL3

1.29e-0327582EFO_0007763
Diseaseresistin measurement

CFH THADA

1.49e-0329582EFO_0004819
Diseasecysteine-rich with EGF-like domain protein 1 measurement

LHFPL4 LHFPL3

1.81e-0332582EFO_0021870
Diseaseinflammatory bowel disease

EPHB4 THADA SPRY4 ZPBP2 SCAMP3

1.88e-03449585EFO_0003767

Protein segments in the cluster

PeptideGeneStartEntry
ACCLFLSVLVMLWLS

TMEM59L

271

Q9UK28
MVALLSQLCWSACRQ

URB2

146

Q14146
CCLWLLGAVLLMDAS

SDF4

21

Q9BRK5
MSAREVAVLLLWLSC

CATSPERE

1

Q5SY80
WLVVFCCRIMALAAA

ABCG8

536

Q9H221
KIICLMLWAICVAED

CFH

6

P08603
LWCVLLLVCMSLFSA

ATP10A

311

O60312
LLVLCCWVAGLMIIV

OR6C2

141

Q9NZP2
CSFIAVLMLRRCLTW

NOX5

281

Q96PH1
SVLCSSVLSIWMCRE

NRTN

11

Q99748
IICFCVWMAAILLSI

ACKR4

156

Q9NPB9
MVQRWLLLSCCGALL

MUC6

1

Q6W4X9
MELRVLLCWASLAAA

EPHB4

1

P54760
MALVRALVCCLLTAW

SMPDL3A

1

Q92484
AKMCILADCTLILAW

ERCC1

186

P07992
MNCVCRLVLVVLSLW

IL11

1

P20809
MRPHLCLQLVTVAWC

OR2W5P

136

A6NFC9
MNRRLCCILVALSWM

OR4M1

136

Q8NGD0
VMSRGLCCVLVAASW

OR4Q2

136

P0C623
SCICWSPMLVLVALA

PTGER1

306

P34995
MRWILCWSLTLCLMA

CES4A

1

Q5XG92
VMCVLLWALSLLRSI

MRGPRX3

141

Q96LB0
MDCTWRILLLVAAAT

IGHV1-69-2

1

A0A0G2JMI3
CVLLMGAAWVLCLLK

OR13J1

141

Q8NGT2
IVSLLLCLLDWCMAL

RALGAPA2

1256

Q2PPJ7
LCLLDWCMALPVSVL

RALGAPA2

1261

Q2PPJ7
KICAWMQLLAALCLV

LHFPL4

126

Q7Z7J7
MLWKLLLRSQSCRLC

MTERF2

1

Q49AM1
MKLLLWACIVCVAFA

PRR27

1

Q6MZM9
MRALWVLGLCCVLLT

HSP90B1

1

P14625
MLCRLCWLVSYSLAV

B3GNT4

26

Q9C0J1
LCALCWMLHVRDKLS

CPLANE1

1276

Q9H799
KMVCFTIWVLAAALC

CCR9

166

P51686
LIICVLVGMVWCSVR

CADM4

336

Q8NFZ8
LMVCLLCVGIFSWCI

LY9

461

Q9HBG7
TLLMVITGVALCCWR

KIRREL2

521

Q6UWL6
WAVCLECSLSMRSVA

KNDC1

56

Q76NI1
ALMRCCLVKWILSST

KCNIP3

41

Q9Y2W7
LFCVPVLRWRSCAML

SLC22A11

336

Q9NSA0
WMCSTLALLLNFLAC

SCAMP3

171

O14828
MAAALKCLLTLGRWC

METTL17

1

Q9H7H0
LQCLMWVAAAICLIA

ATP4A

111

P20648
MNLCLCVQLVAGLWL

OR1C1

136

Q15619
MTGHLCAKLVILCWV

OR11H12

151

B2RN74
SWMLLSCLILLCQVQ

REG3G

11

Q6UW15
PQVCALMLALCWVLT

OR1N1

136

Q8NGS0
QLCALMLGVCWVLTN

OR1N2

156

Q8NGR9
RVGLLMLLCTWLSNC

USO1

491

O60763
CCARWSFMGALSVVL

SPRY4

231

Q9C004
VCCWRSMKEVALLLG

THADA

1051

Q6YHU6
CLTTPIKIALRWFCM

RPTOR

266

Q8N122
IVCCALPMWRVSAFI

CLDN3

21

O15551
IALAVLGWLAVMLCC

CLDN4

11

O14493
MLACLCTVLWHLPAV

CLCF1

11

Q9UBD9
SARPCVWTLCEMLSI

C15orf32

46

Q32M92
LVLSVMVLLWICCAT

TMEM59

246

Q9BXS4
WNTRLLCRVMLCLLG

TRBV13

11

A0A0A6YYD4
WPVIVAALLFCCMIL

CD96

521

P40200
MQRGAALCLRLWLCL

FLT4

1

P35916
MGTRLLCWVAFCLLV

TRBV11-3

1

A0A5A6
VLLCWIVCMLVNIIF

VN1R4

131

Q7Z5H5
SMIVAAFQCLCVWLT

RALGAPB

831

Q86X10
MLKVSAVLCVCAAAW

SPOCK3

1

Q9BQ16
TRRLECLTNWICGML

TMEM81

76

Q6P7N7
RGALMTCAVVLWVLL

TM9SF2

396

Q99805
MDIWLLCWVTLCLLA

TRBV17

1

A0A087X0K7
MSIRLLCCVAFSLLW

TRBV6-4

1

A0A1B0GX49
MMRTCVLLSAVLWCL

ZPBP2

1

Q6X784
MWLLRCVLLCVSLSL

ZP4

1

Q12836
MSIGLLCCAALSLLW

TRBV6-5

1

A0A0K0K1A5
VCFMWCELSVVILLE

WFS1

536

O76024
LWACARTLALQCAMK

ZSWIM4

751

Q9H7M6
CAWMQLTSAACLVLG

LHFPL3

141

Q86UP9