Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranscription coactivator activity

MED12L NCOA6 WWTR1 EP300 BRD4 MED23

5.18e-08303156GO:0003713
GeneOntologyMolecularFunctiontranscription coregulator activity

MED12L NCOA6 WWTR1 EP300 BRD4 MED8 MED23

7.13e-08562157GO:0003712
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

MED12L NCOA6 WWTR1 EP300 BRD4 MED8 MED23

9.34e-061160157GO:0030674
GeneOntologyMolecularFunctionmolecular adaptor activity

MED12L NCOA6 WWTR1 EP300 BRD4 MED8 MED23

2.60e-051356157GO:0060090
GeneOntologyMolecularFunctionprotein antigen binding

EP400 EP300

6.28e-0516152GO:1990405
GeneOntologyMolecularFunctionnuclear glucocorticoid receptor binding

NCOA6 EP300

9.93e-0520152GO:0035259
GeneOntologyMolecularFunctionperoxisome proliferator activated receptor binding

NCOA6 EP300

1.10e-0421152GO:0042975
GeneOntologyMolecularFunctionchromatin binding

EP400 NFAT5 NCOA6 EP300 BRD4

1.51e-04739155GO:0003682
GeneOntologyMolecularFunctionacetylation-dependent protein binding

EP300 BRD4

2.42e-0431152GO:0140033
GeneOntologyMolecularFunctionchromatin-protein adaptor activity

NCOA6 BRD4

4.25e-0441152GO:0140463
GeneOntologyMolecularFunctionp53 binding

EP300 BRD4

1.49e-0377152GO:0002039
GeneOntologyMolecularFunctiontranscription factor binding

MED12L NFAT5 NCOA6 EP300

1.96e-03753154GO:0008134
GeneOntologyMolecularFunctionbeta-catenin binding

MED12L EP300

3.57e-03120152GO:0008013
GeneOntologyMolecularFunctionnuclear receptor binding

NCOA6 EP300

8.45e-03187152GO:0016922
GeneOntologyMolecularFunctionantigen binding

EP400 EP300

8.72e-03190152GO:0003823
GeneOntologyMolecularFunctionmodification-dependent protein binding

EP300 BRD4

1.02e-02206152GO:0140030
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

NFAT5 SP4 EP300 MED8

1.18e-021244154GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

NFAT5 SP4 EP300 MED8

1.27e-021271154GO:0000987
GeneOntologyMolecularFunctionacyltransferase activity

EP300 MED8 MED23

1.87e-02775153GO:0016746
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

NFAT5 SP4 EP300 MED8

2.02e-021459154GO:0000977
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

MED12L NFAT5 NCOA6 WWTR1 EP300 BRD4 MED8 MED23

1.75e-061390158GO:0045944
GeneOntologyBiologicalProcesspositive regulation of transcription elongation by RNA polymerase II

BRD4 MED8 MED23

7.55e-0654153GO:0032968
GeneOntologyBiologicalProcesspositive regulation of DNA-templated transcription, elongation

BRD4 MED8 MED23

1.15e-0562153GO:0032786
GeneOntologyBiologicalProcesspositive regulation of T-helper 17 cell lineage commitment

EP300 BRD4

1.38e-058152GO:2000330
GeneOntologyBiologicalProcessDNA-templated transcription initiation

NCOA6 EP300 MED8 MED23

1.90e-05231154GO:0006352
GeneOntologyBiologicalProcessregulation of T-helper 17 cell lineage commitment

EP300 BRD4

2.70e-0511152GO:2000328
GeneOntologyBiologicalProcessregulation of transcription elongation by RNA polymerase II

BRD4 MED8 MED23

3.88e-0593153GO:0034243
GeneOntologyBiologicalProcessprotein-DNA complex organization

EP400 NFAT5 EP300 BRD4 MED8 MED23

4.36e-05999156GO:0071824
GeneOntologyBiologicalProcesspositive regulation of T-helper 17 cell differentiation

EP300 BRD4

4.47e-0514152GO:2000321
GeneOntologyBiologicalProcessregulation of DNA-templated transcription elongation

BRD4 MED8 MED23

5.58e-05105153GO:0032784
GeneOntologyBiologicalProcesspositive regulation of cell fate commitment

EP300 BRD4

7.50e-0518152GO:0010455
GeneOntologyBiologicalProcesstranscription elongation by RNA polymerase II

BRD4 MED8 MED23

9.83e-05127153GO:0006368
GeneOntologyBiologicalProcessT-helper 17 cell lineage commitment

EP300 BRD4

1.13e-0422152GO:0072540
GeneOntologyBiologicalProcesspositive regulation of T-helper 17 type immune response

EP300 BRD4

1.24e-0423152GO:2000318
GeneOntologyBiologicalProcessDNA-templated transcription elongation

BRD4 MED8 MED23

1.43e-04144153GO:0006354
GeneOntologyBiologicalProcessT-helper cell lineage commitment

EP300 BRD4

1.71e-0427152GO:0002295
GeneOntologyBiologicalProcessCD4-positive, alpha-beta T cell lineage commitment

EP300 BRD4

2.27e-0431152GO:0043373
GeneOntologyBiologicalProcesspositive regulation of T-helper cell differentiation

EP300 BRD4

2.27e-0431152GO:0045624
GeneOntologyBiologicalProcessalpha-beta T cell lineage commitment

EP300 BRD4

2.57e-0433152GO:0002363
GeneOntologyBiologicalProcessregulation of T-helper 17 cell differentiation

EP300 BRD4

2.57e-0433152GO:2000319
GeneOntologyBiologicalProcessCD4-positive or CD8-positive, alpha-beta T cell lineage commitment

EP300 BRD4

2.90e-0435152GO:0043369
GeneOntologyBiologicalProcesstranscription initiation at RNA polymerase II promoter

EP300 MED8 MED23

3.03e-04186153GO:0006367
GeneOntologyBiologicalProcessT cell lineage commitment

EP300 BRD4

4.18e-0442152GO:0002360
GeneOntologyBiologicalProcessDNA damage response

EP400 NFAT5 NCOA6 EP300 BRD4

4.37e-04959155GO:0006974
GeneOntologyBiologicalProcesspositive regulation of CD4-positive, alpha-beta T cell differentiation

EP300 BRD4

4.80e-0445152GO:0043372
GeneOntologyBiologicalProcessT-helper 17 cell differentiation

EP300 BRD4

5.24e-0447152GO:0072539
GeneOntologyBiologicalProcessregulation of T-helper 17 type immune response

EP300 BRD4

5.24e-0447152GO:2000316
GeneOntologyBiologicalProcesspositive T cell selection

EP300 BRD4

6.66e-0453152GO:0043368
GeneOntologyBiologicalProcessregulation of cell fate commitment

EP300 BRD4

6.66e-0453152GO:0010453
GeneOntologyBiologicalProcessprotein-DNA complex assembly

EP300 MED8 MED23

7.10e-04249153GO:0065004
GeneOntologyBiologicalProcessregulation of T-helper cell differentiation

EP300 BRD4

7.70e-0457152GO:0045622
GeneOntologyBiologicalProcessviral transcription

EP300 BRD4

7.97e-0458152GO:0019083
GeneOntologyBiologicalProcesspositive regulation of CD4-positive, alpha-beta T cell activation

EP300 BRD4

7.97e-0458152GO:2000516
GeneOntologyBiologicalProcessT-helper 17 type immune response

EP300 BRD4

9.70e-0464152GO:0072538
GeneOntologyBiologicalProcesspositive regulation of alpha-beta T cell differentiation

EP300 BRD4

9.70e-0464152GO:0046638
GeneOntologyBiologicalProcessT cell selection

EP300 BRD4

1.13e-0369152GO:0045058
GeneOntologyBiologicalProcesspositive regulation of transcription initiation by RNA polymerase II

MED8 MED23

1.16e-0370152GO:0060261
GeneOntologyBiologicalProcessRNA polymerase II preinitiation complex assembly

MED8 MED23

1.19e-0371152GO:0051123
GeneOntologyBiologicalProcessregulation of CD4-positive, alpha-beta T cell differentiation

EP300 BRD4

1.26e-0373152GO:0043370
GeneOntologyBiologicalProcesspositive regulation of DNA-templated transcription initiation

MED8 MED23

1.40e-0377152GO:2000144
GeneOntologyBiologicalProcesspositive regulation of leukocyte cell-cell adhesion

NFAT5 EP300 BRD4

1.43e-03317153GO:1903039
GeneOntologyBiologicalProcesscellular response to heat

EP300 ARPP21

1.55e-0381152GO:0034605
GeneOntologyBiologicalProcessregulation of transcription initiation by RNA polymerase II

MED8 MED23

1.55e-0381152GO:0060260
GeneOntologyBiologicalProcesscanonical NF-kappaB signal transduction

NFAT5 EP300 BRD4

1.60e-03330153GO:0007249
GeneOntologyBiologicalProcesschromatin remodeling

EP400 NFAT5 EP300 BRD4

1.64e-03741154GO:0006338
GeneOntologyBiologicalProcesstranscription preinitiation complex assembly

MED8 MED23

1.70e-0385152GO:0070897
GeneOntologyBiologicalProcesspositive regulation of alpha-beta T cell activation

EP300 BRD4

1.86e-0389152GO:0046635
GeneOntologyBiologicalProcessregulation of DNA-templated transcription initiation

MED8 MED23

1.95e-0391152GO:2000142
GeneOntologyBiologicalProcessmodulation by host of symbiont process

EP300 BRD4

1.95e-0391152GO:0051851
GeneOntologyBiologicalProcessT-helper cell differentiation

EP300 BRD4

1.99e-0392152GO:0042093
GeneOntologyBiologicalProcessregulation of alpha-beta T cell differentiation

EP300 BRD4

2.03e-0393152GO:0046637
GeneOntologyBiologicalProcessCD4-positive, alpha-beta T cell differentiation involved in immune response

EP300 BRD4

2.08e-0394152GO:0002294
GeneOntologyBiologicalProcessalpha-beta T cell differentiation involved in immune response

EP300 BRD4

2.12e-0395152GO:0002293
GeneOntologyBiologicalProcessalpha-beta T cell activation involved in immune response

EP300 BRD4

2.25e-0398152GO:0002287
GeneOntologyBiologicalProcessregulation of CD4-positive, alpha-beta T cell activation

EP300 BRD4

2.34e-03100152GO:2000514
GeneOntologyBiologicalProcessT cell differentiation involved in immune response

EP300 BRD4

2.49e-03103152GO:0002292
GeneOntologyBiologicalProcesspositive regulation of cell-cell adhesion

NFAT5 EP300 BRD4

2.56e-03389153GO:0022409
GeneOntologyBiologicalProcessviral gene expression

EP300 BRD4

2.78e-03109152GO:0019080
GeneOntologyBiologicalProcesspositive regulation of protein localization to nucleus

WWTR1 EP300

3.03e-03114152GO:1900182
GeneOntologyBiologicalProcesschromatin organization

EP400 NFAT5 EP300 BRD4

3.29e-03896154GO:0006325
GeneOntologyBiologicalProcessCD4-positive, alpha-beta T cell differentiation

EP300 BRD4

3.30e-03119152GO:0043367
GeneOntologyBiologicalProcessresponse to heat

EP300 ARPP21

3.41e-03121152GO:0009408
GeneOntologyBiologicalProcesschordate embryonic development

NCOA6 EP300 BRD4 SEC24B

3.42e-03906154GO:0043009
GeneOntologyBiologicalProcessembryo development ending in birth or egg hatching

NCOA6 EP300 BRD4 SEC24B

3.75e-03929154GO:0009792
GeneOntologyBiologicalProcessregulation of leukocyte cell-cell adhesion

NFAT5 EP300 BRD4

3.79e-03447153GO:1903037
GeneOntologyBiologicalProcessbiological process involved in interaction with symbiont

EP300 BRD4

4.22e-03135152GO:0051702
GeneOntologyCellularComponenttranscription regulator complex

NFAT5 NCOA6 WWTR1 EP300 MED8 MED23

1.29e-06596146GO:0005667
GeneOntologyCellularComponentmediator complex

MED12L MED8 MED23

1.83e-0637143GO:0016592
GeneOntologyCellularComponentnuclear protein-containing complex

MED12L EP400 CSTF2 NCOA6 BRD4 MED8 MED23

1.21e-051377147GO:0140513
GeneOntologyCellularComponenttransferase complex

EP400 NCOA6 EP300 BRD4 MED8 MED23

2.05e-05963146GO:1990234
GeneOntologyCellularComponentcore mediator complex

MED8 MED23

1.34e-0426142GO:0070847
GeneOntologyCellularComponenthistone acetyltransferase complex

EP400 EP300

1.76e-0394142GO:0000123
GeneOntologyCellularComponentchromatin

EP400 NFAT5 SP4 EP300 BRD4

2.06e-031480145GO:0000785
GeneOntologyCellularComponentprotein acetyltransferase complex

EP400 EP300

2.15e-03104142GO:0031248
GeneOntologyCellularComponentacetyltransferase complex

EP400 EP300

2.35e-03109142GO:1902493
GeneOntologyCellularComponentintracellular protein-containing complex

EP400 EP300 MED8 MED23

3.20e-03972144GO:0140535
GeneOntologyCellularComponentnuclear chromosome

EP400 BRD4

1.22e-02254142GO:0000228
GeneOntologyCellularComponentRNA polymerase II transcription regulator complex

MED8 MED23

1.38e-02272142GO:0090575
GeneOntologyCellularComponentnuclear body

EP400 CSTF2 WWTR1

2.05e-02903143GO:0016604
MousePhenoabnormal myocardium compact layer morphology

NFAT5 NCOA6 EP300

3.69e-0567143MP:0004056
MousePhenolethality throughout fetal growth and development

NFAT5 NCOA6 EP300 SEC24B MED23

4.52e-05435145MP:0006208
MousePhenoabnormal blastocyst morphology

CSTF2 NCOA6 BRD4 MED23

9.96e-05259144MP:0004957
MousePhenolethality throughout fetal growth and development, complete penetrance

NFAT5 NCOA6 SEC24B MED23

1.06e-04263144MP:0011099
MousePhenoventricular hypoplasia

NCOA6 EP300 SEC24B

1.19e-0499143MP:0000279
MousePhenoabnormal epicardium morphology

NCOA6 EP300

1.26e-0417142MP:0003057
MousePhenoabnormal preimplantation embryo morphology

CSTF2 NCOA6 BRD4 MED23

1.40e-04283144MP:0014137
MousePhenothin ventricular wall

NFAT5 NCOA6 EP300

3.16e-04138143MP:0000280
MousePhenopostnatal lethality, incomplete penetrance

NFAT5 SP4 WWTR1 EP300 BRD4

3.45e-04669145MP:0011086
MousePhenoabnormal myocardial trabeculae morphology

NFAT5 NCOA6 EP300

3.59e-04144143MP:0002189
MousePhenolethality during fetal growth through weaning, incomplete penetrance

NFAT5 NCOA6 SP4 WWTR1 EP300 BRD4

4.55e-041124146MP:0011112
MousePhenoabnormal pluripotent precursor cell morphology

CSTF2 MED23

7.84e-0442142MP:0002399
MousePhenothin myocardium compact layer

NCOA6 EP300

9.40e-0446142MP:0004057
MousePhenoabnormal renal tubule epithelium morphology

NFAT5 WWTR1

1.02e-0348142MP:0009640
MousePhenoabnormal fetal cardiomyocyte proliferation

NFAT5 NCOA6

1.02e-0348142MP:0003567
MousePhenoabnormal cardiac muscle tissue morphology

NFAT5 NCOA6 SP4 EP300

1.12e-03489144MP:0010630
MousePhenokidney atrophy

NFAT5 WWTR1

1.25e-0353142MP:0004970
MousePhenoabnormal embryo development

EP400 CSTF2 NCOA6 EP300 BRD4 MED23

1.32e-031370146MP:0001672
MousePhenoabnormal fetal cardiomyocyte physiology

NFAT5 NCOA6

1.34e-0355142MP:0011390
MousePhenoabnormal heart ventricle wall thickness

NFAT5 NCOA6 EP300

1.35e-03227143MP:0020135
DomainBromodomain_CS

EP300 BRD4

1.93e-0426152IPR018359
DomainBROMODOMAIN_1

EP300 BRD4

3.95e-0437152PS00633
DomainBromodomain

EP300 BRD4

4.16e-0438152PF00439
DomainBROMODOMAIN_2

EP300 BRD4

4.85e-0441152PS50014
DomainBROMO

EP300 BRD4

5.09e-0442152SM00297
DomainBromodomain

EP300 BRD4

5.09e-0442152IPR001487
Domain-

EP300 BRD4

5.09e-04421521.20.920.10
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION

NCOA6 EP300 MED8 MED23

5.60e-0784124M1008
PathwayREACTOME_ADIPOGENESIS

NCOA6 EP300 MED8 MED23

1.66e-06110124M48259
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

NCOA6 EP300 MED8 MED23

2.19e-06118124M27316
PathwayREACTOME_RSV_HOST_INTERACTIONS

EP300 MED8 MED23

6.85e-0598123M48247
PathwayREACTOME_RORA_ACTIVATES_GENE_EXPRESSION

NCOA6 EP300

1.01e-0418122M26942
PathwayREACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_PATHWAY

EP300 MED8 MED23

1.25e-04120123M48233
PathwayREACTOME_METABOLISM_OF_LIPIDS

NCOA6 EP300 MED8 SEC24B MED23

2.54e-04757125M27451
PathwayREACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION

WWTR1 EP300

4.12e-0436122M633
PathwayREACTOME_VIRAL_INFECTION_PATHWAYS

EP300 BRD4 MED8 SEC24B MED23

5.35e-04888125M48034
PathwayREACTOME_HEME_SIGNALING

NCOA6 EP300

7.64e-0449122M41832
PathwayREACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER

WWTR1 EP300

8.28e-0451122M665
PathwayREACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF

NCOA6 SEC24B

9.62e-0455122M27001
PathwayREACTOME_INFECTIOUS_DISEASE

EP300 BRD4 MED8 SEC24B MED23

1.32e-031081125M27548
PathwayREACTOME_CIRCADIAN_CLOCK

NCOA6 EP300

1.55e-0370122M938
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

EP400 CSTF2 NCOA6 WWTR1 EP300 ZMYM4 BRD4 MED8 SEC24B MED23

2.48e-15549151038280479
Pubmed

Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator.

NCOA6 EP300 MED23

3.63e-09815310823961
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

EP400 NCOA6 SP4 EP300 ZMYM4 BRD4 MED8 MED23

5.27e-09110315834189442
Pubmed

Composite co-activator ARC mediates chromatin-directed transcriptional activation.

EP300 MED8 MED23

1.14e-072315310235267
Pubmed

TAZ suppresses NFAT5 activity through tyrosine phosphorylation.

NFAT5 WWTR1

1.74e-07215223045390
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

EP400 CSTF2 NCOA6 WWTR1 EP300 ZMYM4 BRD4

4.81e-07129415730804502
Pubmed

Brd4-p300 inhibition downregulates Nox4 and accelerates lung fibrosis resolution in aged mice.

EP300 BRD4

5.21e-07315232544088
Pubmed

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4.

WWTR1 BRD4

5.21e-07315230224758
Pubmed

Promoter-bound p300 complexes facilitate post-mitotic transmission of transcriptional memory.

EP300 BRD4

5.21e-07315224945803
Pubmed

Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300.

EP400 EP300

5.21e-0731529590171
Pubmed

Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains.

EP300 BRD4

5.21e-07315220676058
Pubmed

Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.

EP300 BRD4

5.21e-07315228262505
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

EP400 ZMYM4 MED8 MED23

6.72e-0716715420362541
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

EP400 ZMYM4 MED8 SEC24B MED23

8.96e-0744415534795231
Pubmed

Human transcription factor protein interaction networks.

EP400 CSTF2 NCOA6 EP300 ZMYM4 MED8 SEC24B

9.38e-07142915735140242
Pubmed

Binding and modulation of p53 by p300/CBP coactivators.

EP400 EP300

1.04e-0641529194565
Pubmed

LPS-induced NFκB enhanceosome requires TonEBP/NFAT5 without DNA binding.

NFAT5 EP300

1.04e-06415227118681
Pubmed

Brd4's Bromodomains Mediate Histone H3 Acetylation and Chromatin Remodeling in Pluripotent Cells through P300 and Brg1.

EP300 BRD4

1.04e-06415230428346
Pubmed

NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism.

EP300 BRD4

1.04e-06415224875858
Pubmed

Transcriptional coactivator PRIP, the peroxisome proliferator-activated receptor gamma (PPARgamma)-interacting protein, is required for PPARgamma-mediated adipogenesis.

NCOA6 EP300

1.04e-06415212754253
Pubmed

Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.

EP300 BRD4

1.04e-06415235716662
Pubmed

Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation.

NCOA6 EP300

1.73e-06515211912212
Pubmed

Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment.

EP300 MED23

1.73e-06515215572696
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MED12L EP400 NCOA6 ZMYM4 MED23

2.12e-0652915514621295
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

EP400 CSTF2 EP300 BRD4 MED8 MED23

2.42e-06101415632416067
Pubmed

Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM).

NCOA6 EP300

2.60e-06615211443112
Pubmed

Degradation, Promoter Recruitment and Transactivation Mediated by the Extreme N-Terminus of MHC Class II Transactivator CIITA Isoform III.

EP400 EP300

2.60e-06615226871568
Pubmed

PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.

EP400 NCOA6 MED23

2.79e-066515322496869
Pubmed

Identification of the hypoxia-inducible factor 2α nuclear interactome in melanoma cells reveals master proteins involved in melanoma development.

EP300 MED8 MED23

2.92e-066615323275444
Pubmed

Genetic interaction mapping in mammalian cells using CRISPR interference.

EP400 MED8 MED23

3.34e-066915328481362
Pubmed

A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome.

WWTR1 EP300

3.64e-06715216332960
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

EP400 NCOA6 BRD4 MED8

4.40e-0626815433640491
Pubmed

Quantitative Mass Spectrometry Identifies Novel Host Binding Partners for Pathogenic Escherichia coli Type III Secretion System Effectors.

EP300 SEC24B

4.85e-06815227018634
Pubmed

The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy.

EP300 BRD4

4.85e-06815223752591
Pubmed

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.

EP400 NCOA6 EP300

5.84e-068315328794006
Pubmed

HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.

EP300 MED23

7.80e-061015223746844
Pubmed

DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.

EP300 MED8 MED23

9.93e-069915334161765
Pubmed

Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.

NCOA6 EP300

1.14e-051215212189208
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

EP400 EP300 ZMYM4 SEC24B MED23

1.18e-0575415535906200
Pubmed

Interaction network of human early embryonic transcription factors.

EP400 NCOA6 EP300 ZMYM4

1.27e-0535115438297188
Pubmed

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.

EP400 CSTF2 ZMYM4 MED23

1.36e-0535715437059091
Pubmed

SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.

NCOA6 EP300

2.08e-051615223870121
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

EP400 NFAT5 MED23

2.25e-0513015312421765
Pubmed

Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in β-adrenergic receptor signaling.

NCOA6 EP300

2.35e-051715228291835
Pubmed

Transcription factor protein interactomes reveal genetic determinants in heart disease.

EP400 EP300 ZMYM4 BRD4

2.37e-0541115435182466
Pubmed

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.

EP400 BRD4 MED23

2.46e-0513415325452129
Pubmed

Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.

CSTF2 NCOA6 EP300 MED8

2.70e-0542515424999758
Pubmed

Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode.

EP300 BRD4

2.96e-051915227626385
Pubmed

Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription.

EP300 MED23

2.96e-051915216204234
Pubmed

T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.

NCOA6 EP300

3.28e-052015211877444
Pubmed

Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor.

NCOA6 EP300

3.63e-052115219596656
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

EP400 CSTF2 NCOA6 ZMYM4 BRD4

3.67e-0595415536373674
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

EP400 NCOA6 EP300

3.95e-0515715330186101
Pubmed

The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro.

EP300 MED23

3.99e-052215211867769
Pubmed

P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma.

EP400 EP300

5.18e-052515236708875
Pubmed

Subunit architecture and functional modular rearrangements of the transcriptional mediator complex.

MED8 MED23

5.61e-052615224882805
Pubmed

Novel critical role of a human Mediator complex for basal RNA polymerase II transcription.

MED8 MED23

5.61e-052615211559591
Pubmed

Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network.

MED8 MED23

5.61e-052615234506481
Pubmed

A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.

MED8 MED23

7.00e-052915214638676
Pubmed

The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.

MED8 MED23

8.02e-053115223322298
Pubmed

TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.

BRD4 MED23

9.10e-053315233567268
Pubmed

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

EP300 BRD4

9.10e-053315226864203
Pubmed

MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription.

MED8 MED23

9.66e-053415215989967
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

EP300 ZMYM4 MED23

1.07e-0422015335785414
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

EP400 ZMYM4 BRD4

1.10e-0422215337071664
Pubmed

Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease.

MED8 MED23

1.27e-043915238690566
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

EP400 EP300 MED8 MED23

1.36e-0464515425281560
Pubmed

Accumulation of NCOA1 dependent on HERC3 deficiency transactivates matrix metallopeptidases and promotes extracellular matrix degradation in intervertebral disc degeneration.

EP300 BRD4

1.55e-044315236878279
Pubmed

Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.

NCOA6 EP300 MED23

1.57e-0425015318660489
Pubmed

Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1.

ZMYM4 SEC24B

1.70e-044515233596420
Pubmed

The protein interaction landscape of the human CMGC kinase group.

EP400 EP300 MED8 MED23

1.81e-0469515423602568
Pubmed

A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.

MED8 MED23

1.86e-044715215175163
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

EP400 NCOA6 BRD4

2.26e-0428315330585729
Pubmed

Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.

MED8 MED23

2.45e-045415216239144
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

EP400 NCOA6 ZMYM4 BRD4

2.73e-0477415415302935
Pubmed

Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.

NCOA6 MED23

2.93e-045915228813667
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

EP400 ZMYM4 MED8 SEC24B MED23

3.07e-04149715531527615
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

EP400 WWTR1 EP300 ZMYM4

4.02e-0485715425609649
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

NCOA6 WWTR1 BRD4 SEC24B

4.09e-0486115436931259
Pubmed

Streamlined analysis schema for high-throughput identification of endogenous protein complexes.

MED8 MED23

4.24e-047115220133760
InteractionMED23 interactions

MED12L EP400 NCOA6 EP300 BRD4 MED8 MED23

3.79e-10266157int:MED23
InteractionKLF5 interactions

EP400 NCOA6 WWTR1 EP300 ZMYM4 BRD4

3.54e-09195156int:KLF5
InteractionMED1 interactions

MED12L NCOA6 EP300 BRD4 MED8 MED23

4.92e-09206156int:MED1
InteractionWWTR1 interactions

EP400 CSTF2 NCOA6 WWTR1 EP300 BRD4 SEC24B

9.35e-09422157int:WWTR1
InteractionMED28 interactions

MED12L WWTR1 BRD4 MED8 MED23

1.66e-08116155int:MED28
InteractionHNF4A interactions

EP400 NCOA6 EP300 ZMYM4 MED8 MED23

2.76e-08275156int:HNF4A
InteractionMED15 interactions

MED12L NCOA6 BRD4 MED8 MED23

3.06e-08131155int:MED15
InteractionMED20 interactions

MED12L EP300 BRD4 MED8 MED23

1.54e-07181155int:MED20
InteractionAR interactions

MED12L EP400 NCOA6 EP300 ZMYM4 BRD4 MED8 MED23

1.58e-07992158int:AR
InteractionMED13L interactions

MED12L BRD4 MED8 MED23

1.87e-0771154int:MED13L
InteractionMED11 interactions

MED12L BRD4 MED8 MED23

1.87e-0771154int:MED11
InteractionMED18 interactions

MED12L BRD4 MED8 MED23

3.20e-0781154int:MED18
InteractionYAP1 interactions

NFAT5 NCOA6 WWTR1 EP300 ZMYM4 BRD4 MED8 MED23

3.38e-071095158int:YAP1
InteractionMED30 interactions

MED12L BRD4 MED8 MED23

3.70e-0784154int:MED30
InteractionMED22 interactions

MED12L BRD4 MED8 MED23

3.88e-0785154int:MED22
InteractionMED13 interactions

MED12L BRD4 MED8 MED23

4.07e-0786154int:MED13
InteractionMED7 interactions

MED12L EP400 MED8 MED23

5.34e-0792154int:MED7
InteractionSOX9 interactions

EP400 NCOA6 EP300 BRD4

6.61e-0797154int:SOX9
InteractionMED6 interactions

MED12L BRD4 MED8 MED23

7.77e-07101154int:MED6
InteractionMED10 interactions

MED12L BRD4 MED8 MED23

8.09e-07102154int:MED10
InteractionMED29 interactions

MED12L BRD4 MED8 MED23

8.09e-07102154int:MED29
InteractionMED27 interactions

MED12L BRD4 MED8 MED23

8.09e-07102154int:MED27
InteractionCEBPA interactions

EP400 NCOA6 SP4 EP300 ZMYM4 BRD4 MED8 MED23

9.03e-071245158int:CEBPA
InteractionMED19 interactions

MED12L BRD4 MED8 MED23

9.44e-07106154int:MED19
InteractionMED26 interactions

MED12L BRD4 MED8 MED23

9.80e-07107154int:MED26
InteractionMED9 interactions

MED12L BRD4 MED8 MED23

1.02e-06108154int:MED9
InteractionMRGBP interactions

EP400 BRD4 MED8 MED23

1.06e-06109154int:MRGBP
InteractionTBXT interactions

NCOA6 EP300 ZMYM4 MED8

1.35e-06116154int:TBXT
InteractionTP53BP1 interactions

EP400 NCOA6 WWTR1 EP300 BRD4 MED8

1.36e-06533156int:TP53BP1
InteractionPOLR2A interactions

CSTF2 WWTR1 EP300 BRD4 MED8 MED23

1.40e-06536156int:POLR2A
InteractionMED16 interactions

MED12L BRD4 MED8 MED23

1.55e-06120154int:MED16
InteractionACTL6A interactions

EP400 WWTR1 EP300 BRD4 MED8

1.56e-06289155int:ACTL6A
InteractionMED8 interactions

MED12L BRD4 MED8 MED23

1.60e-06121154int:MED8
InteractionMED31 interactions

MED12L BRD4 MED8 MED23

1.83e-06125154int:MED31
InteractionMED24 interactions

MED12L BRD4 MED8 MED23

2.01e-06128154int:MED24
InteractionPML interactions

EP400 EP300 ZMYM4 BRD4 MED8 SEC24B MED23

2.07e-06933157int:PML
InteractionFOS interactions

EP400 NFAT5 NCOA6 EP300 MED8

2.28e-06312155int:FOS
InteractionNCOA2 interactions

NCOA6 WWTR1 EP300 MED23

2.95e-06141154int:NCOA2
InteractionNCOA6 interactions

NCOA6 WWTR1 EP300 MED23

3.30e-06145154int:NCOA6
InteractionKAT5 interactions

EP400 CSTF2 EP300 BRD4 MED23

4.46e-06358155int:KAT5
InteractionMED21 interactions

MED12L BRD4 MED8 MED23

4.76e-06159154int:MED21
InteractionDCAF7 interactions

WWTR1 EP300 BRD4 SEC24B MED23

5.10e-06368155int:DCAF7
InteractionMED12L interactions

MED12L MED8 MED23

5.30e-0647153int:MED12L
InteractionRXRA interactions

NCOA6 EP300 BRD4 MED23

6.06e-06169154int:RXRA
InteractionMED14 interactions

MED12L BRD4 MED8 MED23

6.35e-06171154int:MED14
InteractionEGR2 interactions

EP400 NCOA6 EP300 ZMYM4

6.35e-06171154int:EGR2
InteractionRB1 interactions

NCOA6 WWTR1 EP300 BRD4 MED23

7.12e-06394155int:RB1
InteractionMED12 interactions

MED12L BRD4 MED8 MED23

7.12e-06176154int:MED12
InteractionFHL2 interactions

EP400 NFAT5 SP4 EP300 ZMYM4

7.29e-06396155int:FHL2
InteractionEP400 interactions

EP400 WWTR1 BRD4 MED23

8.49e-06184154int:EP400
InteractionCCNC interactions

MED12L BRD4 MED8 MED23

9.24e-06188154int:CCNC
InteractionE2F1 interactions

NCOA6 SP4 EP300 BRD4

1.18e-05200154int:E2F1
InteractionMED17 interactions

MED12L BRD4 MED8 MED23

1.23e-05202154int:MED17
InteractionHOXA10 interactions

WWTR1 EP300 BRD4

1.23e-0562153int:HOXA10
InteractionFEV interactions

EP400 NCOA6 EP300 ZMYM4

1.25e-05203154int:FEV
InteractionNUMA1 interactions

NCOA6 WWTR1 EP300 ZMYM4 BRD4

1.65e-05469155int:NUMA1
InteractionCDK8 interactions

MED12L ZMYM4 MED8 MED23

1.78e-05222154int:CDK8
InteractionEPC1 interactions

EP400 EP300 MED23

2.75e-0581153int:EPC1
InteractionCRX interactions

EP400 SP4 EP300 ZMYM4

3.02e-05254154int:CRX
InteractionCPSF1 interactions

CSTF2 EP300 BRD4 MED8

3.06e-05255154int:CPSF1
InteractionINTS9 interactions

BRD4 MED8 MED23

3.18e-0585153int:INTS9
InteractionSELENOP interactions

EP400 EP300

3.40e-0512152int:SELENOP
InteractionESRRB interactions

EP400 CSTF2 MED8 MED23

3.40e-05262154int:ESRRB
InteractionCDK19 interactions

MED12L MED8 MED23

3.52e-0588153int:CDK19
InteractionTERF2IP interactions

EP400 NCOA6 ZMYM4 BRD4 ARPP21

3.62e-05552155int:TERF2IP
InteractionRBM14 interactions

CSTF2 NCOA6 EP300 BRD4 MED23

3.65e-05553155int:RBM14
InteractionDYRK1B interactions

EP400 EP300 MED23

3.90e-0591153int:DYRK1B
InteractionASCL2 interactions

NCOA6 EP300

4.01e-0513152int:ASCL2
InteractionMED25 interactions

BRD4 MED8 MED23

4.16e-0593153int:MED25
InteractionSLX4 interactions

EP400 CSTF2 ZMYM4 BRD4 MED23

4.29e-05572155int:SLX4
InteractionADAR interactions

EP400 WWTR1 EP300 BRD4

4.79e-05286154int:ADAR
InteractionRBBP5 interactions

NCOA6 EP300 BRD4 MED23

4.86e-05287154int:RBBP5
InteractionTFCP2L1 interactions

EP400 ZMYM4 BRD4

5.01e-0599153int:TFCP2L1
InteractionQSER1 interactions

WWTR1 BRD4 SEC24B

5.17e-05100153int:QSER1
InteractionHCFC1 interactions

EP400 NCOA6 WWTR1 BRD4

5.27e-05293154int:HCFC1
InteractionCREBBP interactions

NCOA6 WWTR1 EP300 BRD4 MED23

5.35e-05599155int:CREBBP
InteractionHSF1 interactions

EP400 NCOA6 EP300 SEC24B MED23

5.79e-05609155int:HSF1
InteractionCSTF2T interactions

CSTF2 WWTR1 BRD4

5.97e-05105153int:CSTF2T
InteractionKHSRP interactions

WWTR1 EP300 BRD4 SEC24B

6.39e-05308154int:KHSRP
InteractionDCAF12 interactions

EP400 WWTR1 MED23

6.50e-05108153int:DCAF12
InteractionKMT2A interactions

NCOA6 WWTR1 BRD4 MED8

6.89e-05314154int:KMT2A
InteractionTBR1 interactions

EP300 ZMYM4 BRD4

7.44e-05113153int:TBR1
InteractionTFAP2A interactions

WWTR1 EP300 BRD4

7.63e-05114153int:TFAP2A
InteractionRUNX1 interactions

CSTF2 WWTR1 EP300 ZMYM4

7.78e-05324154int:RUNX1
InteractionETS1 interactions

EP400 EP300 MED23

9.11e-05121153int:ETS1
InteractionRUNX2 interactions

WWTR1 EP300 BRD4

1.03e-04126153int:RUNX2
InteractionVDR interactions

NCOA6 EP300 MED23

1.05e-04127153int:VDR
InteractionDDB1 interactions

CSTF2 EP300 BRD4 MED8 MED23

1.10e-04697155int:DDB1
InteractionTCEA1 interactions

EP300 BRD4 MED23

1.15e-04131153int:TCEA1
InteractionCXXC1 interactions

NCOA6 EP300 MED8

1.18e-04132153int:CXXC1
InteractionPAX6 interactions

EP400 NCOA6 EP300 ZMYM4

1.25e-04366154int:PAX6
InteractionCTBP2 interactions

CSTF2 EP300 BRD4 MED23

1.30e-04370154int:CTBP2
InteractionRAD50 interactions

WWTR1 EP300 BRD4 MED23

1.31e-04371154int:RAD50
InteractionRBM27 interactions

WWTR1 EP300 BRD4

1.32e-04137153int:RBM27
InteractionCSTF3 interactions

CSTF2 EP300 BRD4

1.37e-04139153int:CSTF3
InteractionTLE3 interactions

CSTF2 EP300 BRD4 MED23

1.38e-04376154int:TLE3
InteractionTLE6 interactions

WWTR1 EP300

1.54e-0425152int:TLE6
InteractionVPS72 interactions

EP400 WWTR1 EP300

1.59e-04146153int:VPS72
InteractionRPRD2 interactions

WWTR1 BRD4 MED8

1.59e-04146153int:RPRD2
InteractionCPSF3 interactions

CSTF2 EP300 BRD4

1.59e-04146153int:CPSF3
CytobandEnsembl 112 genes in cytogenetic band chr3q25

MED12L WWTR1

1.55e-03180152chr3q25
CytobandEnsembl 112 genes in cytogenetic band chr1p34

ZMYM4 MED8

4.06e-03294152chr1p34
GeneFamilyCyclins|Mediator complex

MED12L MED8 MED23

6.59e-07331031061
ToppCellTCGA-Peripheral_Nervous_System-Primary_Tumor-Paraganglioma-Paraganglioma-3|TCGA-Peripheral_Nervous_System / Sample_Type by Project: Shred V9

NFAT5 HS6ST2 MED23

1.17e-05135153ac20133d4a36f48338b45bffb13e842cb66f83ad
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

HS6ST2 ARPP21

7.36e-0412115205c40fd39e6b6275f35aaad835f95a81fcbb0990
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_low-phase|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CSTF2 HS6ST2

1.04e-03144152f6061dd965a2b2fe6ad864f8aecc06d2e74881ce
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D175|Adult / Lineage, Cell type, age group and donor

HS6ST2 ARPP21

1.13e-03150152b0b6ba3686d3eb8a9b249d30be14111de3b893be
ToppCellAdult-Epithelial-basal_cell-D175|Adult / Lineage, Cell type, age group and donor

MED12L HS6ST2

1.17e-031531529ee3e7f3f19a2474283c1c79045269686f35a541
ToppCell3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MED12L ARPP21

1.17e-0315315282b77c8bae49dd63b8f10eb67df66ca71d0bb315
ToppCellFetal_29-31_weeks-Immune-dendritic_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MED12L ARPP21

1.20e-031551529f937ae48767fdcf1a944af4de0530d9c0ab441d
ToppCellfacs-Trachea-24m-Hematologic-myeloid-granulocyte-granulocyte_l26|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HS6ST2 ARPP21

1.22e-03156152da5cfa8fa9595613f04ce9511f8b42bad34d995a
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

HS6ST2 WWTR1

1.26e-031591528680b054622f573a82b1625fb93c2d5db81d1034
ToppCellChildren_(3_yrs)-Immune-dendritic_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

MED12L ARPP21

1.31e-0316215286a0b9dabd150dc993bfc0f3344804de7f8e4042
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NCOA6 ARPP21

1.33e-031631522d6fd2562d78be9f83fa35d811eb7e27eb8cc5d1
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

HS6ST2 ARPP21

1.33e-03163152218b9ba099cb27aa91c6b73bf89b44895f5dddc3
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MED12L ARPP21

1.36e-03165152e2a70dd5870fe8708bf630ed3e6eb3f295df0cdf
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Myeloid-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MED12L HS6ST2

1.43e-03169152bca5322880c09b78ef10d9dda6420a80c1ba7e62
ToppCellICU-SEP-Myeloid-pDC|ICU-SEP / Disease, Lineage and Cell Type

MED12L ARPP21

1.46e-0317115272c448a0dc4c569bd6b465f9aa395f38034e7ea6
ToppCellPND03-Immune-Immune_Myeloid-Megakaryocyte/Platelet|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MED12L ARPP21

1.48e-03172152e39ea2f4edbf36ebf9604fa6f9349081859c596c
ToppCelldroplet-Lung-18m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MED12L NCOA6

1.48e-03172152ebeda7ef181cac0109be750a98e7589c615d2724
ToppCellPND03-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MED12L ARPP21

1.48e-03172152875ea290840e835952623b905eb610f3c71456d2
ToppCellPND03-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MED12L ARPP21

1.48e-03172152bcc50bed47465daa953ba91f17d1ee4c947ab461
ToppCellmild_COVID-19-pDC|World / disease group, cell group and cell class (v2)

MED12L ARPP21

1.48e-03172152dab2f1a05c7df58d9387b13271b3f1f1583f9ac3
ToppCellE18.5-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MED12L CSTF2

1.48e-031721521bbf5ed7d13635f9a7e528060341e0652699bd7c
ToppCellCOPD-Myeloid-pDC|World / Disease state, Lineage and Cell class

MED12L ARPP21

1.51e-03174152be8227398300711ccda5ecc41ad34064bb246b19
ToppCellBAL-Control-Myeloid-pDC-pDC-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MED12L ARPP21

1.51e-03174152ab654e87c7eab7f33adc61be7a86da5c4d88008d
ToppCellBAL-Control-Myeloid-pDC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MED12L ARPP21

1.51e-03174152d9bccff5258c4277bdd1edbd87e17c327ec125e8
ToppCellBAL-Control-Myeloid-pDC-pDC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MED12L ARPP21

1.51e-031741522453419842fd22d066631615403393bfe4449bb8
ToppCellAdult-Epithelial-basal_cell-D231|Adult / Lineage, Cell type, age group and donor

MED12L HS6ST2

1.51e-03174152a4f98afe7d1cc2617f6f7bc8092c41df57474b30
ToppCellBAL-Control-Myeloid-pDC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MED12L ARPP21

1.53e-031751526d5bdfbe53608e01c3845ecd908ca6d0fecc58f8
ToppCellnucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-pDC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MED12L ARPP21

1.53e-0317515237c2d4e0b6e9a3171931797ce9a54f3347288e57
ToppCellBAL-Control-Myeloid-pDC-pDC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MED12L ARPP21

1.53e-031751529d6135e183179968555670abec39dff9da2c3219
ToppCellIPF-Myeloid-pDC|World / Disease state, Lineage and Cell class

MED12L ARPP21

1.53e-03175152a06785a4ded01adfd29ca4c20f7759eccbe274cb
ToppCellmild_COVID-19-pDC|mild_COVID-19 / disease group, cell group and cell class (v2)

MED12L ARPP21

1.53e-03175152b87f279a7519710146c49d6acccb0adedc195965
ToppCellBAL-Control-Myeloid-pDC-pDC-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MED12L ARPP21

1.53e-031751526839ee3bb4457d13cb08ca8eb79ae33ddd256783
ToppCellFetal_29-31_weeks-Immune-dendritic_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MED12L ARPP21

1.56e-03177152c5e829bc4594761666d65cace5a9c5d19c16f187
ToppCellControl-Myeloid-pDC|Control / Disease state, Lineage and Cell class

MED12L ARPP21

1.56e-031771523940663bb5b45b2ca9f772550380a516c53e410b
ToppCellAdult-Epithelial-club_cell-D175|Adult / Lineage, Cell type, age group and donor

HS6ST2 WWTR1

1.56e-03177152d652b7d84fe6aa38319d8d5adc72c70441bd0088
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NFAT5 SP4

1.56e-03177152f28243b51be104cb3adcde63f03fc2206ed3121e
ToppCellCOPD-Myeloid-pDC|COPD / Disease state, Lineage and Cell class

MED12L ARPP21

1.56e-03177152415aa023195a7f961c09529f65cdcc7bb90eaf5d
ToppCellIPF-Myeloid-pDC|IPF / Disease state, Lineage and Cell class

MED12L ARPP21

1.58e-031781528d9e28492e1f157bac3308aa947fd864ca16d277
ToppCellHealthy/Control-pDC|Healthy/Control / Disease group and Cell class

MED12L ARPP21

1.58e-03178152072b346c6bbd63f00efaceda486400a669b3ec48
ToppCellCOPD-Myeloid-pDC|Myeloid / Disease state, Lineage and Cell class

MED12L ARPP21

1.60e-0317915229b058c5e33fda9f0d738c074bdb67ff16b9b6d5
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-Ly6g5b+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP4 HS6ST2

1.62e-031801525c649e2b3f5a53c0040b69df6e289fb3427ef2db
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

HS6ST2 WWTR1

1.63e-03181152c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCellPCW_07-8.5-Neuronal-Neuronal_SCP-neuro_pre_proliferating_SCP_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

HS6ST2 ARPP21

1.65e-03182152bfb725fff3d20066d8ac0a6ba2f88498fcbd876e
ToppCellHealthy/Control-pDC|World / Disease group and Cell class

MED12L ARPP21

1.65e-0318215297e0eee10905f2cf2bebb09e474629fc224f4397
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MED12L ARPP21

1.65e-03182152be32b5b8153c1053cbb55f1fccfa27c3ee97c1e1
ToppCell18-Distal-Immune-Hematopoietic,_B_Cells|Distal / Age, Tissue, Lineage and Cell class

MED12L ARPP21

1.65e-03182152cd0b9f0a25147ec3bc1e32d698511d1c3b33891f
ToppCellAdult-Epithelial-basal_cell|Adult / Lineage, Cell type, age group and donor

MED12L HS6ST2

1.67e-0318315200a6b19ca49e3b8e0d1cd387a3515b0ff4b81c81
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MED12L ARPP21

1.67e-03183152df6fd0927b6e4cf9a1583969a68096e4bccfbace
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MED12L ARPP21

1.67e-031831523b123571e10c132227aff65648b4b3c6acb4bd00
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

HS6ST2 WWTR1

1.70e-0318515298b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCellnormal-na-Myeloid-plasmacytoid_dendritic_cell-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

MED12L ARPP21

1.70e-031851523091870a5bf8ecb963e560b47c8502bae367416c
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

HS6ST2 WWTR1

1.70e-03185152cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MED12L ARPP21

1.72e-031861520096a61b1841784c913752b4f3639200446cc02c
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MED12L ARPP21

1.72e-031861529e159ad7289dcae2ec7ce655df746f46801b81d3
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

NFAT5 EP300

1.72e-0318615203db813598b67b1e08f759758a1c2023396921fa
ToppCell3'_v3-blood-Hematopoietic_progenitors-Progenitor_Erythro-Mega|blood / Manually curated celltypes from each tissue

MED12L ARPP21

1.72e-0318615259c115bbbb4bca4ad80be1809d8a0422b8438ea3
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MED12L ARPP21

1.72e-031861526345777847960c71a2ba3ce5a49c72c34ebd0e73
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

HS6ST2 WWTR1

1.74e-0318715277886f99c229610abd28c4c370d2c7d1536c9782
ToppCellHealthy_donor-pDC|World / disease group, cell group and cell class (v2)

MED12L ARPP21

1.74e-03187152aa2cc54487d3c5045ac0c93560944c5a55878e27
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)|Striatum / BrainAtlas - Mouse McCarroll V32

HS6ST2 ARPP21

1.76e-03188152e34ea7014c5a059a7db38f78bd903cf02616ddd3
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MED12L HS6ST2

1.76e-03188152bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Neuronal-medium_spiny_neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HS6ST2 ARPP21

1.78e-031891523e8e30160a8d6f531ff743cb5918c9e79481f1bd
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Neuronal-SPN_Neuron_STR|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HS6ST2 ARPP21

1.78e-03189152851f8144aed5c7f80302911cd6b03f14bde7b56d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MED12L HS6ST2

1.78e-03189152977a813e5d7a5a561c1fced2bbf21c20056b88d8
ToppCellAdult-Epithelial-club_cell|Adult / Lineage, Cell type, age group and donor

HS6ST2 WWTR1

1.80e-03190152756bff697d30aec56c0ebfca94295f084a15bf37
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HS6ST2 ARPP21

1.80e-031901521c5cf933ce71fed5638b9ef31eb81f6c2b6dadbc
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MED12L HS6ST2

1.80e-03190152e252e925600e6457fa6e362a55217f4cffa75cdb
ToppCellChildren_(3_yrs)-Epithelial-club_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

HS6ST2 WWTR1

1.82e-0319115223776c7302cead3881b39127398f3b3e0d27885e
ToppCellfacs-Pancreas-Exocrine-3m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HS6ST2 WWTR1

1.85e-03193152c3161a14a40323a58aa202c8a1d6ea0e9c2b9814
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

ZMYM4 MED23

1.85e-03193152abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Radial_glial-gliogenic/outer_RGCs_and_astrocytes|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

HS6ST2 WWTR1

1.87e-031941527c6c0376603e5fcb64814fd6204d153629c2fbf5
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NFAT5 WWTR1

1.87e-03194152abacb6a8d7a9003f2f6c2be0305507f1c1c50347
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NFAT5 WWTR1

1.87e-0319415246070fbb0ee0eb9e1801c43b73a15707471056dc
ToppCellnucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

HS6ST2 WWTR1

1.87e-031941520cd4363627acd419e00d6d32f6dce10430aa6487
ToppCellnucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS-RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

HS6ST2 WWTR1

1.87e-03194152a58841b34efe673671a9a059238e044a7254b279
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MED12L HS6ST2

1.89e-03195152a38d9dc6192aea673d96fda6b25e81223fda3abf
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HS6ST2 ARPP21

1.89e-03195152787e95fb59c40bba784544b662fac37606ae1427
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HS6ST2 ARPP21

1.89e-03195152ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-skeletal_muscle_satellite_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HS6ST2 ARPP21

1.91e-031961523dc6394c5de1f875a19ad0e8799827fad29f8f02
ToppCellMesenchymal_cells-Myofibroblasts|World / Lineage and Cell class

HS6ST2 WWTR1

1.91e-031961522c0f429ae18c2df05c33ddf58dcc2c94b819b9a1
ToppCellmild-pDC|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MED12L ARPP21

1.93e-0319715215230a54fa5903dd728de1a0ad633bd2d2c7a04d
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HS6ST2 ARPP21

1.93e-0319715227c044833e471a312a572e0b1c83e4bc8a36e896
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW09-Neuronal-GABAergic_neurons|GW09 / Sample Type, Dataset, Time_group, and Cell type.

SP4 SEC24B

1.93e-0319715221f3ef7c3c10b4e3adde431097dfdcd513c74a95
ToppCellmild-pDC|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MED12L ARPP21

1.93e-031971520cb00daa6943f7a7fb34a8fdf51188646af65686
ToppCelldistal-Hematologic-Plasmacytoid_Dendritic-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MED12L ARPP21

1.93e-031971523a5908deb5c5a2bf06019a102fb1652233cf2a2a
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HS6ST2 WWTR1

1.95e-031981521408e02e053ad3406229bfe8189da03be6366e81
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HS6ST2 WWTR1

1.95e-03198152af399569c718f5fd971d73a7926768c9311002a3
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-IN_Progenitors|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.

HS6ST2 WWTR1

1.95e-031981523811d9e3e54bbe8b208c591697e43b55ab5bbf0e
ToppCellsevere-pDC|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MED12L ARPP21

1.95e-031981523c4820a8391088682fb3e47b914f872533bae227
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HS6ST2 ARPP21

1.95e-031981525e70246a9ce199cb2fb5379912b8ab59456219e4
ToppCellkidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EP400 MED23

1.97e-03199152174f6013af6eafa577f84205a62927f2b367fda3
ToppCellLPS_only-Hematopoietic_Lymphocytic-B_cells-B-cells|LPS_only / Treatment groups by lineage, cell group, cell type

ARPP21 SEC24B

1.97e-031991527c297a36af047fe47412695e82320cec8a4be83c
ToppCellLPS_IL1RA-Hematopoietic_Lymphocytic-B_cells-B-cells|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ARPP21 SEC24B

1.97e-031991520eb8c72edcd34fe0f7ab9438c9c872d63576ef3a
ToppCellLPS_IL1RA_TNF-Hematopoietic_Lymphocytic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ARPP21 SEC24B

1.97e-031991525611b9e405a685a7a099d2f2d21dee3a939c2911
ToppCellLPS_only-Hematopoietic_Lymphocytic-B_cells|LPS_only / Treatment groups by lineage, cell group, cell type

ARPP21 SEC24B

1.97e-03199152fce4dc28547ae28b99ea9cf7e27c66d6a108fce5
ToppCellLPS_IL1RA-Hematopoietic_Lymphocytic-B_cells|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ARPP21 SEC24B

1.97e-031991522cdc8ae6357723b9e7c0c66be656e6f748a6aa2d
ToppCellLPS_anti-TNF-Hematopoietic_Lymphocytic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ARPP21 SEC24B

1.97e-03199152333e472c82df659ac9b235285eafe39109da7940
ToppCellLPS_IL1RA_TNF-Hematopoietic_Lymphocytic-B_cells|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ARPP21 SEC24B

1.99e-03200152d124acbe5d46220850fe485ed78f032daddca5b1
ToppCellLPS_anti-TNF-Hematopoietic_Lymphocytic-B_cells-B-cells|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ARPP21 SEC24B

1.99e-032001524c8007a158f0f6b6fa259b25d2387b648bb2fc0d
ToppCellLPS_IL1RA_TNF-Hematopoietic_Lymphocytic-B_cells-B-cells|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ARPP21 SEC24B

1.99e-03200152c07e37db9d50b91378d9c8355168745560cdbd25
DrugAC1L9FY1

EP400 NFAT5 EP300 BRD4

4.80e-07101154CID000444218
Diseasecolon cancer (is_implicated_in)

NCOA6 BRD4

1.50e-0436152DOID:219 (is_implicated_in)
Diseaseirritability measurement

NCOA6 ARPP21

7.82e-0482152EFO_0009594
Diseasesodium measurement

NFAT5 ARPP21

1.23e-03103152EFO_0009282
DiseaseIntellectual Disability

MED12L BRD4 MED23

1.37e-03447153C3714756
Diseasepuberty onset measurement

NFAT5 NCOA6

1.80e-03125152EFO_0005677
Diseasetea consumption measurement

NFAT5 ARPP21

1.92e-03129152EFO_0010091
DiseaseVertigo

MED12L ARPP21

2.22e-03139152HP_0002321
Diseaseosteoarthritis, knee

NFAT5 EP300

2.86e-03158152EFO_0004616
Diseasepost-traumatic stress disorder

SP4 ZMYM4

4.62e-03202152EFO_0001358
Diseaserisk-taking behaviour

NFAT5 EP300 ARPP21

6.23e-03764153EFO_0008579
Diseasered blood cell density measurement

EP400 SP4 BRD4

9.20e-03880153EFO_0007978
Diseaseneuroticism measurement

SP4 HS6ST2 ARPP21

1.01e-02909153EFO_0007660
Diseasevitamin D measurement

SP4 MED23

1.23e-02336152EFO_0004631
Diseasegrip strength measurement

NFAT5 ARPP21

1.33e-02350152EFO_0006941

Protein segments in the cluster

PeptideGeneStartEntry
QQGVHSNPAMQNMNP

EP300

2121

Q09472
PTSQLQAQGQMQTQA

EP400

2891

Q96L91
QAQGQMQTQAPQPAQ

EP400

2896

Q96L91
MSTTQAQAQPQPANA

BRD4

26

O60885
GSNVSMNQQNPQAPQ

CSTF2

216

P33240
SAMVGQSQQQPPQQQ

ARPP21

511

Q9UBL0
TQMPLQQTSQQQAGS

MED12L

1946

Q86YW9
QAMNSGSPAPQSNQV

MED23

1346

Q9ULK4
NPMPQSQQGTMFQSQ

NFAT5

1221

O94916
ASSPTVNQTQQQMGP

NCOA6

441

Q14686
MNNQQAGTSGVPQVN

NCOA6

591

Q14686
GQSQNPNQNQSQNPN

HS6ST2

536

Q96MM7
HQQNGPAQNQMQVPS

SEC24B

41

O95487
QQVQMAGAPSQQQPM

MED8

221

Q96G25
EAQSSSQLQPNGMQN

SP4

371

Q02446
SQLQPNGMQNAQDQS

SP4

376

Q02446
PPSQNNAANISMVQA

ZMYM4

856

Q5VZL5
QQQMAPSTLSQQNHP

WWTR1

196

Q9GZV5
ENAGQTPMNINPQQT

WWTR1

341

Q9GZV5