Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural molecule activity	COL7A1 COL9A3 HMCN2 PNN EPB41L4B KRT84 MRPL37 EMILIN2 MRPL3 POM121C SHANK3 SNTB1 COL1A2	7.44e-05	891	83	13	GO:0005198
GeneOntologyBiologicalProcess	guanylate kinase-associated protein clustering	NRXN1 SHANK3	1.60e-05	2	83	2	GO:0097117
GeneOntologyBiologicalProcess	anatomical structure homeostasis	HNF1A NXNL1 USH1G RP1L1 SRF LTBP3 TMEM64 TJP3	5.97e-05	334	83	8	GO:0060249
GeneOntologyBiologicalProcess	tissue homeostasis	HNF1A NXNL1 USH1G RP1L1 SRF LTBP3 TMEM64 TJP3	5.97e-05	334	83	8	GO:0001894
GeneOntologyBiologicalProcess	neurotransmitter-gated ion channel clustering	NRXN1 FRRS1L SHANK3	9.16e-05	22	83	3	GO:0072578
GeneOntologyCellularComponent	collagen trimer	COL7A1 COL9A3 COL20A1 EMILIN2 C1QTNF5 COL1A2	1.46e-06	88	84	6	GO:0005581
GeneOntologyCellularComponent	collagen-containing extracellular matrix	COL7A1 COL9A3 HMCN2 COL20A1 NTN3 EMILIN2 SHH LTBP3 COL1A2	2.75e-04	530	84	9	GO:0062023
Domain	Collagen	COL7A1 COL9A3 COL20A1 C1QTNF5 COL1A2	3.59e-05	85	82	5	IPR008160
Domain	Collagen	COL7A1 COL9A3 COL20A1 C1QTNF5 COL1A2	3.59e-05	85	82	5	PF01391
Domain	DUF3523	ATAD3B ATAD3A	5.70e-05	3	82	2	PF12037
Domain	DUF3523	ATAD3B ATAD3A	5.70e-05	3	82	2	IPR021911
Domain	PDZ	MAGI1 ARHGAP23 SHANK3 SNTB1 TJP3	3.91e-04	141	82	5	PF00595
Domain	PDZ	MAGI1 ARHGAP23 SHANK3 SNTB1 TJP3	4.88e-04	148	82	5	SM00228
Domain	-	MAGI1 ARHGAP23 SHANK3 SNTB1 TJP3	5.19e-04	150	82	5	2.30.42.10
Domain	PDZ	MAGI1 ARHGAP23 SHANK3 SNTB1 TJP3	5.35e-04	151	82	5	PS50106
Domain	PDZ	MAGI1 ARHGAP23 SHANK3 SNTB1 TJP3	5.51e-04	152	82	5	IPR001478
Domain	GUANYLATE_KINASE_2	MAGI1 TJP3	4.54e-03	23	82	2	PS50052
Domain	GUANYLATE_KINASE_1	MAGI1 TJP3	4.54e-03	23	82	2	PS00856
Domain	VWFA	COL7A1 HMCN2 COL20A1	5.63e-03	82	82	3	PS50234
Domain	Guanylate_kin	MAGI1 TJP3	5.78e-03	26	82	2	PF00625
Domain	GK/Ca_channel_bsu	MAGI1 TJP3	5.78e-03	26	82	2	IPR008145
Domain	Guanylate_kin-like_dom	MAGI1 TJP3	5.78e-03	26	82	2	IPR008144
Domain	GuKc	MAGI1 TJP3	5.78e-03	26	82	2	SM00072
Domain	VWA	COL7A1 HMCN2 COL20A1	6.02e-03	84	82	3	SM00327
Domain	-	HNF1A ONECUT3	6.22e-03	27	82	2	1.10.260.40
Domain	AT_hook	PRR12 KMT2B	6.22e-03	27	82	2	SM00384
Domain	AT_hook_DNA-bd_motif	PRR12 KMT2B	6.22e-03	27	82	2	IPR017956
Domain	Lambda_DNA-bd_dom	HNF1A ONECUT3	7.16e-03	29	82	2	IPR010982
Domain	-	HOXB2 HNF1A HMX1 ONECUT3 TERF2	8.15e-03	283	82	5	1.10.10.60
Domain	C1Q	EMILIN2 C1QTNF5	8.67e-03	32	82	2	SM00110
Domain	C1q	EMILIN2 C1QTNF5	8.67e-03	32	82	2	PF00386
Pathway	REACTOME_COLLAGEN_CHAIN_TRIMERIZATION	COL7A1 COL9A3 COL20A1 COL1A2	2.67e-05	41	60	4	MM15538
Pathway	REACTOME_COLLAGEN_CHAIN_TRIMERIZATION	COL7A1 COL9A3 COL20A1 COL1A2	3.54e-05	44	60	4	M27812
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	COL7A1 COL9A3 COL20A1 COL1A2	1.29e-04	61	60	4	MM14637
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	COL7A1 COL9A3 COL20A1 COL1A2	1.86e-04	67	60	4	M26999
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	COL7A1 COL9A3 NRXN1 COL20A1 EMILIN2 LTBP3 COL1A2	2.71e-04	300	60	7	M610
Pathway	REACTOME_COLLAGEN_FORMATION	COL7A1 COL9A3 COL20A1 COL1A2	3.03e-04	76	60	4	MM14573
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PRR12 ATAD3B ALMS1 ARHGAP23 ATAD3A POM121C NEURL4 SHANK3 ANO8 SEMA4C	3.62e-07	493	85	10	15368895
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PRR12 SRXN1 FLNC FAM89A KMT2B ZNF316 ADGRB2 DYRK1A LTBP3 MBD6 FHIP1B POM121C ANO8 TJP3	4.58e-07	1105	85	14	35748872
Pubmed	Deletion of ATAD3A inhibits osteogenesis by impairing mitochondria structure and function in pre-osteoblast.	ATAD3B ATAD3A COL1A2	2.29e-06	11	85	3	36000457
Pubmed	Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies.	ZXDA ZXDB	5.90e-06	2	85	2	8268913
Pubmed	Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death.	HNF1A SRF	5.90e-06	2	85	2	15542842
Pubmed	DYRK1A suppression restrains Mcl-1 expression and sensitizes NSCLC cells to Bcl-2 inhibitors.	DYRK1A MCL1	5.90e-06	2	85	2	32587776
Pubmed	ATAD 3A and ATAD 3B are distal 1p-located genes differentially expressed in human glioma cell lines and present in vitro anti-oncogenic and chemoresistant properties.	ATAD3B ATAD3A	5.90e-06	2	85	2	18639545
Pubmed	Molecular characterization of the tumor-associated antigen AAA-TOB3.	ATAD3B ATAD3A	5.90e-06	2	85	2	16909202
Pubmed	Cloning, mapping, and expression of a novel brain-specific transcript in the familial dysautonomia candidate region on chromosome 9q31.	EPB41L4B FRRS1L	5.90e-06	2	85	2	10603000
Pubmed	The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization.	ATAD3B ATAD3A	5.90e-06	2	85	2	17210950
Pubmed	[ATAD3, a vital membrane-bound mitochondrial ATPase involved in tumor progression].	ATAD3B ATAD3A	1.77e-05	3	85	2	22192748
Pubmed	ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism.	ATAD3B ATAD3A	1.77e-05	3	85	2	28549128
Pubmed	ATAD3B is a human embryonic stem cell specific mitochondrial protein, re-expressed in cancer cells, that functions as dominant negative for the ubiquitous ATAD3A.	ATAD3B ATAD3A	1.77e-05	3	85	2	22664726
Pubmed	ATAD3 is a limiting factor in mitochondrial biogenesis and adipogenesis of white adipocyte-like 3T3-L1 cells.	ATAD3B ATAD3A	1.77e-05	3	85	2	38923254
Pubmed	ATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly.	ATAD3B ATAD3A	1.77e-05	3	85	2	34936866
Pubmed	Mitochondria-associated membrane formation in hormone-stimulated Leydig cell steroidogenesis: role of ATAD3.	ATAD3B ATAD3A	1.77e-05	3	85	2	25375035
Pubmed	Myocardin-related transcription factor-A complexes activate type I collagen expression in lung fibroblasts.	SRF COL1A2	3.53e-05	4	85	2	22049076
Pubmed	ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.	ATAD3B ATAD3A	3.53e-05	4	85	2	35236834
Pubmed	Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis.	ATAD3B ATAD3A	3.53e-05	4	85	2	36736924
Pubmed	The SIRT3-ATAD3A axis regulates MAM dynamics and mitochondrial calcium homeostasis in cardiac hypertrophy.	ATAD3B ATAD3A	3.53e-05	4	85	2	38250153
Pubmed	Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells.	ATAD3B ATAD3A	3.53e-05	4	85	2	29242539
Pubmed	Brief report: SRF-dependent MiR-210 silences the sonic hedgehog signaling during cardiopoesis.	SRF SHH	3.53e-05	4	85	2	23818299
Pubmed	Rare functional genetic variants in COL7A1, COL6A5, COL1A2 and COL5A2 frequently occur in Chiari Malformation Type 1.	COL7A1 COL1A2	3.53e-05	4	85	2	33974636
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	EGLN2 ZNF219 SERBP1 ASPHD1 ATAD3A NTN3 SRF DYRK1A LMTK3 TERF2 ANO8	3.89e-05	1021	85	11	26760575
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	COL7A1 COL9A3 HMCN2 EMILIN2 COL1A2	5.78e-05	167	85	5	22159717
Pubmed	Expression analysis of ATAD3 isoforms in rodent and human cell lines and tissues.	ATAD3B ATAD3A	5.87e-05	5	85	2	24239551
Pubmed	Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities.	SHH MCL1	5.87e-05	5	85	2	30232009
Pubmed	Stability related bias in residues replacing glycines within the collagen triple helix (Gly-Xaa-Yaa) in inherited connective tissue disorders.	COL7A1 COL1A2	5.87e-05	5	85	2	15365990
Pubmed	Egr-1 and serum response factor are involved in growth factors- and serum-mediated induction of E2-EPF UCP expression that regulates the VHL-HIF pathway.	SRF UBE2S	5.87e-05	5	85	2	18780286
Pubmed	The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances.	RBM33 SHH	5.87e-05	5	85	2	27867070
Pubmed	ATAD3 controls mitochondrial cristae structure in mouse muscle, influencing mtDNA replication and cholesterol levels.	ATAD3B ATAD3A	5.87e-05	5	85	2	29898916
Pubmed	Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation.	MAGI1 SHANK3 SNTB1	7.98e-05	34	85	3	30726710
Pubmed	Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.	HNF1A DYRK1A	8.80e-05	6	85	2	14500717
Pubmed	Fancd2-deficient hematopoietic stem and progenitor cells depend on augmented mitochondrial translation for survival and proliferation.	ATAD3B ATAD3A	8.80e-05	6	85	2	31472450
Pubmed	The complete primary structure of the long form of mouse alpha 1(IX) collagen chain and its expression during limb development.	COL9A3 COL1A2	8.80e-05	6	85	2	8305476
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	FLNC PNN LRP10 EPB41L4B DYRK1A NEURL4	1.22e-04	313	85	6	38270169
Pubmed	Liver-enriched transcription factors regulate microRNA-122 that targets CUTL1 during liver development.	HNF1A SRF	1.23e-04	7	85	2	20842632
Pubmed	Mapping the Shh long-range regulatory domain.	RBM33 SHH	1.23e-04	7	85	2	25252942
Pubmed	ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.	ATAD3B ATAD3A	1.64e-04	8	85	2	30914652
Pubmed	Atad3 function is essential for early post-implantation development in the mouse.	ATAD3B ATAD3A	1.64e-04	8	85	2	23372768
Pubmed	Human transcription factor protein interaction networks.	PRR12 HNF1A ATAD3B KMT2B ALMS1 PNN RBM33 ATAD3A MRPL37 MBD6 POM121C SNTB1	1.82e-04	1429	85	12	35140242
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	FLNC ATAD3B MGAT2 SERBP1 BRI3BP ARHGAP23 RBM33 ATAD3A NADK2 DYRK1A MCL1 LTBP3	2.09e-04	1451	85	12	30550785
Pubmed	Using mouse models of autism spectrum disorders to study the neurotoxicology of gene-environment interactions.	NRXN1 SHANK3	2.10e-04	9	85	2	23010509
Pubmed	Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system.	HOXB2 SHH	3.20e-04	11	85	2	10357893
Pubmed	Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles.	HNF1A SHH	3.20e-04	11	85	2	1363228
Pubmed	Behavioral phenotypes of genetic mouse models of autism.	NRXN1 SHANK3	3.20e-04	11	85	2	26403076
Pubmed	FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA.	ATAD3B ATAD3A	3.20e-04	11	85	2	37279268
Pubmed	SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.	FLNC SERBP1 ATAD3A KRT84 MRPL37 MRPL3 COL1A2	4.42e-04	558	85	7	27591049
Pubmed	Advancing the understanding of autism disease mechanisms through genetics.	NRXN1 SHANK3	4.52e-04	13	85	2	27050589
Pubmed	Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6.	HNF1A SRF	4.52e-04	13	85	2	12606287
Pubmed	Expression patterns of the lysophospholipid receptor genes during mouse early development.	SHH S1PR4	4.52e-04	13	85	2	18924241
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	ATAD3B SERBP1 NRXN1 ATAD3A FRRS1L ADGRB2 MRPL3 HNRNPLL SHANK3 ANO8	4.62e-04	1139	85	10	36417873
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	ALMS1 PNN EPB41L4B RBM33 POM121C	4.77e-04	263	85	5	34702444
Pubmed	USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification.	ATAD3B LRP10 ATAD3A	4.80e-04	62	85	3	31340145
Pubmed	Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.	COL7A1 SHH COL1A2	4.80e-04	62	85	3	28344315
Pubmed	Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis.	SHH COL1A2	5.27e-04	14	85	2	17194222
Pubmed	TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology.	NRXN1 SHANK3	5.27e-04	14	85	2	27979975
Pubmed	Differential regulation of cranial and cardiac neural crest by serum response factor and its cofactors.	SRF SHH	5.27e-04	14	85	2	35044299
Pubmed	Filamin C is Essential for mammalian myocardial integrity.	FLNC COL1A2	5.27e-04	14	85	2	36706168
Pubmed	Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.	COL7A1 COL9A3 EMILIN2 COL1A2	5.53e-04	153	85	4	25037231
Pubmed	Collagen II is essential for the removal of the notochord and the formation of intervertebral discs.	COL9A3 COL1A2	6.07e-04	15	85	2	9832566
Pubmed	Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density.	MAGI1 SNTB1	6.07e-04	15	85	2	23782696
Pubmed	The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway.	ALMS1 SHH	6.07e-04	15	85	2	26035863
Pubmed	Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation.	HNF1A COL1A2	6.07e-04	15	85	2	15866165
Pubmed	Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crest.	HOXB2 SHH	6.07e-04	15	85	2	11532923
Pubmed	p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.	MAGI1 ATAD3B ATAD3A SNTB1	6.39e-04	159	85	4	30581152
Pubmed	DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis.	ATAD3B ATAD3A DYRK1A	6.85e-04	70	85	3	34255829
Pubmed	Serum response factor is essential for mesoderm formation during mouse embryogenesis.	SRF SHH	6.93e-04	16	85	2	9799237
Pubmed	MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders.	NRXN1 SHANK3	7.84e-04	17	85	2	27779093
Pubmed	Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling.	SHH COL1A2	7.84e-04	17	85	2	23895934
Pubmed	A germline-specific class of small RNAs binds mammalian Piwi proteins.	COL9A3 KMT2B LRP10 RBM33 EMILIN2 LTBP3	8.39e-04	450	85	6	16751776
Pubmed	Serum response factor controls transcriptional network regulating epidermal function and hair follicle morphogenesis.	SRF SHH	8.80e-04	18	85	2	23151848
Pubmed	Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression.	SHH MCL1	8.80e-04	18	85	2	11290297
Pubmed	Plzf regulates limb and axial skeletal patterning.	HOXB2 SHH	9.83e-04	19	85	2	10835630
Pubmed	A Wnt/Notch/Pax7 signaling network supports tissue integrity in tongue development.	SHH COL1A2	9.83e-04	19	85	2	28438836
Pubmed	Pinin modulates expression of an intestinal homeobox gene, Cdx2, and plays an essential role for small intestinal morphogenesis.	PNN SHH	1.09e-03	20	85	2	20637749
Pubmed	Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb development.	SHH COL1A2	1.09e-03	20	85	2	16169709
Pubmed	Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds.	SHH COL1A2	1.20e-03	21	85	2	23034633
Pubmed	Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract.	SHH COL1A2	1.32e-03	22	85	2	20430747
Pubmed	FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod.	SHH COL1A2	1.32e-03	22	85	2	17544391
Pubmed	Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation.	SHH HMX1	1.32e-03	22	85	2	14645517
Pubmed	Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels.	SRF COL1A2	1.32e-03	22	85	2	25516967
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	EPB41L4B ADGRB2 LSM11 SHANK3	1.41e-03	197	85	4	36604605
Pubmed	Six1 is essential for early neurogenesis in the development of olfactory epithelium.	EGLN2 SHH	1.57e-03	24	85	2	17880938
Pubmed	WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation.	KRT84 SHH	1.57e-03	24	85	2	28589954
Pubmed	The protein interaction landscape of the human CMGC kinase group.	RTF1 EGLN2 ATAD3B ALMS1 PNN DYRK1A NEURL4	1.58e-03	695	85	7	23602568
Pubmed	Associations of 25 structural, degradative, and inflammatory candidate genes with lumbar disc desiccation, bulging, and height narrowing.	COL9A3 COL1A2	1.71e-03	25	85	2	19180518
Pubmed	Interaction network of human early embryonic transcription factors.	PRR12 KMT2B ALMS1 MBD6 POM121C	1.73e-03	351	85	5	38297188
Pubmed	An ID2-dependent mechanism for VHL inactivation in cancer.	EGLN2 DYRK1A	1.85e-03	26	85	2	26735018
Pubmed	Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.	FLNC ATAD3B PNN ATAD3A	1.94e-03	215	85	4	30462309
Pubmed	Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs.	ATAD3B MCL1 TMEM64	1.98e-03	101	85	3	19167051
Pubmed	SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development.	HOXB2 SRF	1.99e-03	27	85	2	20417598
Pubmed	Chondromodulin I is dispensable during enchondral ossification and eye development.	COL9A3 COL1A2	1.99e-03	27	85	2	12192060
Pubmed	Rebalancing gene haploinsufficiency in vivo by targeting chromatin.	KMT2B KCNQ4	2.14e-03	28	85	2	27256596
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	RTF1 ALMS1 NRXN1 DAGLA	2.29e-03	225	85	4	12168954
Pubmed	Resistance to noise-induced hearing loss in 129S6 and MOLF mice: identification of independent, overlapping, and interacting chromosomal regions.	KCNQ4 USH1G	2.30e-03	29	85	2	24952082
Pubmed	Non-trisomic homeobox gene expression during craniofacial development in the Ts65Dn mouse model of Down syndrome.	DYRK1A CLIC6	2.30e-03	29	85	2	23843306
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	PRR12 EGLN2 ZNF497 KMT2B KCNC3 UBE2S PLEKHG2 LMTK3 CTU1	3.66e-04	1192	85	9	chr19q13
GeneFamily	Collagens	COL7A1 COL9A3 COL20A1 COL1A2	1.22e-05	46	56	4	490
GeneFamily	PDZ domain containing	MAGI1 ARHGAP23 SHANK3 SNTB1 TJP3	1.06e-04	152	56	5	1220
Coexpression	NABA_CORE_MATRISOME	COL7A1 COL9A3 HMCN2 COL20A1 NTN3 EMILIN2 LTBP3 COL1A2	2.77e-06	270	85	8	MM17057
Coexpression	NABA_CORE_MATRISOME	COL7A1 COL9A3 HMCN2 COL20A1 NTN3 EMILIN2 LTBP3 COL1A2	3.17e-06	275	85	8	M5884
Coexpression	NABA_COLLAGENS	COL7A1 COL9A3 COL20A1 COL1A2	1.15e-05	43	85	4	MM17060
Coexpression	NABA_COLLAGENS	COL7A1 COL9A3 COL20A1 COL1A2	1.27e-05	44	85	4	M3005
Coexpression	IVANOVA_HEMATOPOIESIS_STEM_CELL	HOXB2 NRXN1 RASD1 ZXDA ZXDB SEMA4C	4.34e-05	196	85	6	MM667
Coexpression	GSE36392_TYPE_2_MYELOID_VS_MAC_IL25_TREATED_LUNG_UP	SRXN1 FLNC NRXN1 KCNQ4 KRT84 SEMA4C	4.85e-05	200	85	6	M5273
ToppCell	TCGA-Mesothelium-Primary_Tumor-Mesothelioma-Biphasic\|TCGA-Mesothelium / Sample_Type by Project: Shred V9	C9orf40 COL20A1 KRT84 RP1L1 UBE2S C1QTNF5 PLEKHG2	3.31e-08	167	85	7	9062577a4b7902c9a888d706589d1b05221c0fa8
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	COL7A1 ZNF219 ALMS1 ATAD3A PLEKHG2 ZXDB	1.15e-06	177	85	6	eb0cfe8e9a91910f9979608ed47add48d98ce4dd
ToppCell	droplet-Kidney-nan-3m-Mesenchymal-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM89A COL9A3 ARHGAP23 COL20A1 NTN3 COL1A2	1.31e-06	181	85	6	0b1e7335648823b1d83bdfa878ccd44efe7bba9a
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM89A COL9A3 NRXN1 COL20A1 DAGLA COL1A2	1.49e-06	185	85	6	ca69499ba8c39b7ed6717d05685d6f70066a77bd
ToppCell	Globus_pallidus\|World / BrainAtlas - Mouse McCarroll V32	COL7A1 TPCN2 LTBP3 CLIC6 MBD6	4.36e-06	126	85	5	44b63f945d5bedf1a2ca1810e7e100276ea9dd89
ToppCell	3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Differentiating_glia\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL9A3 NRXN1 COL20A1 DAGLA SNTB1	2.26e-05	177	85	5	0417460bdb012bc43d7254377fa53d79cdab3f34
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	COL7A1 ZNF219 ALMS1 ATAD3A ZXDB	2.33e-05	178	85	5	9d575902d3dbe33437c9d4200df093a741269803
ToppCell	E12.5-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	LURAP1L FAM89A SHH CLIC6 TJP3	2.59e-05	182	85	5	204530444e35d4977a7239ac176f477e9e5c29ab
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FAM89A COL9A3 EPB41L4B COL20A1 DAGLA	2.59e-05	182	85	5	a1c0e4090a9e7aa4941a40c817d178de144888b6
ToppCell	wk_20-22-Epithelial-PNS-intermediate_Schwann\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ZNF219 TPCN2 NRXN1 EPB41L4B TMEM64	2.73e-05	184	85	5	4e3ba64692868563a579902aa9c6f88cab5bce26
ToppCell	Control-Endothelial-VE_Peribronchial\|Control / Disease state, Lineage and Cell class	MAGI1 ARHGAP23 C2CD4A C1QTNF5 SHANK3	3.02e-05	188	85	5	f5b7dbc89f992c13280d36a34935be83906b1bc0
ToppCell	(2)_Fibroblasts-(20)_Fibro-1\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	FLNC HMCN2 EMILIN2 ALKAL2 COL1A2	3.02e-05	188	85	5	409a7b69d02e87084ca955e3fe6c77230dee8861
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	FLNC NXNL1 SLC49A3 CLIC6	3.05e-05	93	85	4	af489f0dd76c3c1a84d164283149f550a7ece91c
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Coch_(Coch)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	FLNC NXNL1 SLC49A3 CLIC6	3.05e-05	93	85	4	c1d0afcfa37c2dcbb12189b4ce56ae7c4bb7ba30
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Coch_(Coch)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	FLNC NXNL1 SLC49A3 CLIC6	3.05e-05	93	85	4	0ea74c2820372d60d3804bf2c8bb0d03733dff98
ToppCell	Control-Endothelial-VE_Peribronchial\|World / Disease state, Lineage and Cell class	MAGI1 ARHGAP23 C2CD4A C1QTNF5 SHANK3	3.10e-05	189	85	5	c76d8af2e0aa4a83ee0c3439c894566fbf117dd3
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HOXB2 NRXN1 KCNQ4 DAGLA COL1A2	3.10e-05	189	85	5	ca3a04c202afc32aa11d17154066ef7dc6d01405
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNC ADGRB2 EMILIN2 LTBP3 COL1A2	3.26e-05	191	85	5	9214655dca96d766737c9f30b624d7fe7050342e
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	LURAP1L EPB41L4B CLIC6 LMTK3 TJP3	3.34e-05	192	85	5	8899d81306770adda893b5e146df1253971754c5
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	LURAP1L EPB41L4B CLIC6 LMTK3 TJP3	3.34e-05	192	85	5	5fda9a465c9f77c7fa1a3ea07a2b0374bbc23b2a
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FLNC COL9A3 NRXN1 ADGRB2 COL1A2	3.42e-05	193	85	5	cd45118ced91b10baed3b1068d4673ec99824b86
ToppCell	Fetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FAM89A ARHGAP23 RP1L1 PLEKHG2 SHANK3	3.42e-05	193	85	5	ad2df9b77999780860141be6ec366afc0172a331
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-AT2-2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	COL7A1 RASD1 ONECUT3 ZXDA ZXDB	3.51e-05	194	85	5	5bfc26668fa8f109f2ebc0d5fd98ab5bd219e62c
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SRXN1 FLNC LTBP3 POM121C COL1A2	3.87e-05	198	85	5	399760b6b6fef8639ded53b14f251b9fce600e81
ToppCell	LPS-IL1RA-Epithelial_alveolar-Mes-Like-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLNC KCNC3 ZNF316 SLC49A3	4.55e-05	103	85	4	eb9f008b5fb8a01df8ea4faf6e6aebc1a9db9bd3
Disease	neuromuscular disease (implicated_via_orthology)	ATAD3B ATAD3A	4.23e-05	4	79	2	DOID:440 (implicated_via_orthology)
Disease	Semantic-Pragmatic Disorder	NRXN1 SHANK3	3.83e-04	11	79	2	C0454655
Disease	Auditory Processing Disorder, Central	NRXN1 SHANK3	3.83e-04	11	79	2	C0751257
Disease	Language Delay	NRXN1 SHANK3	3.83e-04	11	79	2	C0023012
Disease	Language Development Disorders	NRXN1 SHANK3	3.83e-04	11	79	2	C0023014
Disease	Speech Delay	NRXN1 SHANK3	3.83e-04	11	79	2	C0241210
Disease	serum alanine aminotransferase measurement	HNF1A TPCN2 EPB41L4B RP1L1 DYRK1A SHH MCL1 POM121C TJP3	5.21e-04	869	79	9	EFO_0004735
Disease	autism spectrum disorder (is_implicated_in)	DYRK1A MBD6	8.29e-04	16	79	2	DOID:0060041 (is_implicated_in)
Disease	syndrome (implicated_via_orthology)	ATAD3B ATAD3A	1.05e-03	18	79	2	DOID:225 (implicated_via_orthology)
Disease	Schizophrenia	NRXN1 SHANK3	1.05e-03	18	79	2	cv:C0036341
Disease	level of Phosphatidylcholine (16:0_22:5) in blood serum	HNF1A DAGLA	1.05e-03	18	79	2	OBA_2045079
Disease	level of Sterol ester (27:1/20:3) in blood serum	HNF1A NRXN1	1.18e-03	19	79	2	OBA_2045199
Disease	colorectal cancer, inflammatory bowel disease	ALMS1 KCNQ4	1.18e-03	19	79	2	EFO_0003767, MONDO_0005575
Disease	citrulline measurement	HMCN2 RP1L1	1.30e-03	20	79	2	EFO_0009777
Disease	diastolic blood pressure, systolic blood pressure	RTF1 TPCN2 ALMS1 RBM33 SHH MCL1 TERF2	2.13e-03	670	79	7	EFO_0006335, EFO_0006336

Protein segments in the cluster

Peptide	Gene	Start	Entry
LHGLGREDGGLDGVG	USH1G	326	Q495M9
REDGGLDGVGAPRGR	USH1G	331	Q495M9
GGGGGEDAPRARPEG	ADGRB2	1366	O60241
GLRGDVGDRGPGGAA	COL9A3	421	Q14050
GLLAPGAQGARGRGG	BRI3BP	26	Q8WY22
QPGAEGGGDRGLGDR	ATAD3A	26	Q9NVI7
LDGRGYLAGPGREAG	ALMS1	4011	Q8TCU4
ILGVETGGPGGRRAG	DYRK1A	426	Q13627
GGGGPDRGPEAEARG	CLIC6	61	Q96NY7
RAGGEGRDQGPDGGP	ANO8	681	Q9HCE9
GGRRGGPLMCRGVGD	RBM33	276	Q96EV2
KLLRAGSGGGGGDPG	RASD1	226	Q9Y272
NRREATPRGGGDGGG	HNRNPLL	41	Q8WVV9
EINFGDLGRPGRGGR	SERBP1	356	Q8NC51
RRGRAGGAGEGPGHL	FHIP1B	616	Q8N612
GGGGLRGINGEARPA	MBD6	861	Q96DN6
LRCGAELGSPGGGGG	NRXN1	6	P58400
GFGDGRGVGLGPRAD	KRT84	86	Q9NSB2
GLGSGLGAGEGLGER	LRP10	316	Q7Z4F1
EEGDGAAGAGRRGPG	LSM11	121	P83369
EAAGLPGGGEGPRLG	MAGI1	51	Q96QZ7
LLDAEPARGAGGRGG	MGAT2	41	Q10469
AGGRAAALRGPGAGG	NADK2	16	Q4G0N4
GDGQPLGLRLGAGRG	HMCN2	821	Q8NDA2
LGAGSRAGGVRGGPV	ASPHD1	106	Q5U4P2
AGGGGSPRRLGLLGS	KCNQ4	36	P56696
GGAPRAPGAGRLDLG	LMTK3	1096	Q96Q04
APGAGRLDLGSGGRA	LMTK3	1101	Q96Q04
ALSGPGGGRGRGSLL	PNN	46	Q9H307
RGAGTGGLGLAIEGP	FLNC	1376	Q14315
GPGGEARARALLGPG	HMX1	76	Q9NP08
GGGRGELAELPNGLG	HNF1A	51	P20823
ALRRGGGATGPGGAE	KMT2B	46	Q9UMN6
GQLGLGGFGAPRRGA	MRPL37	16	Q9BZE1
RDGRGRGCGGPAGAA	POM121C	21	A8CG34
DGLGLPEAGGGGARR	HOXB2	131	P14652
AGGAGGRGPGLIAAR	NTN3	536	O00634
GLRGEIGNPGRDGAR	COL1A2	661	P08123
LPGRDGRDGRDGAPG	C1QTNF5	46	Q9BXJ0
GRGGRHLEGRGEPGA	COL20A1	1251	Q9P218
ADDGAGPGGRGPRGR	FRRS1L	31	Q9P0K9
RLARGGGLGSPGEGG	CTU1	191	Q7Z7A3
RERDRDPCGGSGGGG	LURAP1L	36	Q8IV03
GLGGRVEGGPAGERG	LTBP3	36	Q9NS15
EVGGGGGGPASRGEL	DAGLA	881	Q9Y4D2
GRAGGVGEAGRPGER	COL7A1	2046	Q02388
GAGVSGRGLPRGVDG	EMILIN2	856	Q9BXX0
LRDGFGGQDGGELRP	EGLN2	76	Q96KS0
ELPGARLPGGGGDDG	C9orf40	111	Q8IXQ3
RLPGGGGDDGAGRAG	C9orf40	116	Q8IXQ3
GGDDGAGRAGPPRGD	C9orf40	121	Q8IXQ3
GLLGRETLGPGGGCS	RTL8C	6	O15255
HSGRLAGRGGPEDGG	S1PR4	31	O95977
AGRGGPEDGGLGALR	S1PR4	36	O95977
AAGLGDERDGGPRGG	EPB41L4B	26	Q9H329
GGGGGPDALLGTLRV	C2CD4A	136	Q8NCU7
GGLGSGGELHPRTGR	NEURL4	36	Q96JN8
LGAGSGGATRPGGRL	MCL1	21	Q07820
EDALARGLPGGGGGT	ONECUT3	256	O60422
GRLGDGLGAALGPGN	MRPL3	16	P09001
LAGGQEGSPGGGRRG	RTF1	21	Q92541
GPAGAGGGRAQRSGL	SNTB1	11	Q13884
RGGGGGRVALTAPGA	SHH	406	Q15465
QDELSRGGPGGGGAR	FAM89A	61	Q96GI7
ERLAGGGVLGPAGLG	PRR12	206	Q9ULL5
RLQLGGEDRGGLGHP	SEMA4C	791	Q9C0C4
GNGAGLGPGRLEREA	SRF	46	P11831
LGAAGRGRGGAEPRE	ALKAL2	16	Q6UX46
QPGAEGGGDRGLGDR	ATAD3B	26	Q5T9A4
GVGRGGGGAEPRQER	C11orf68	11	Q9H3H3
GVDRGGAGRAGVLGP	SLC49A3	471	Q6UXD7
GAGGDGPADRLPRGG	TMEM64	36	Q6YI46
LLPARGTLQGGGGGG	ZXDB	6	P98169
GRELGPADGGRDGAG	ZNF497	71	Q6ZNH5
PEGAAGGARGSAGGR	XKR7	16	Q5GH72
AARGGRDPGGGGGEE	NXNL1	191	Q96CM4
CIDGAGLGGPEQGGR	RP1L1	506	Q8IWN7
RVEGLGAGAGGAGRP	SHANK3	1586	Q9BYB0
GRPDGEGAGRGGPRA	ARHGAP23	1326	Q9P227
GGTLGRAGAGRGAPE	SRXN1	6	Q9BYN0
GPVGLRAAGDGRGGA	ZNF654	26	Q8IZM8
GLCSGLGARGFPGGR	nan	151	Q8N1X5
GGAGGPSGRAEAGRA	UBE2S	156	Q16763
GFGIAISGGRDRPGG	TJP3	21	O95049
LLPARGTLQGGGGGG	ZXDA	6	P98168
GGGCAEAGGDGPRRE	ZNF316	506	A6NFI3
LEGAFRGGGGGGPRL	PLEKHG2	316	Q9H7P9
GLGGPAERGAGEARL	TERF2	76	Q15554
GLLVGGTRPEGGRGA	ZNF219	481	Q9P2Y4
AESEPLLGGARGGGG	TPCN2	6	Q8NHX9
GGGGLDGAGGELKRL	KCNC3	231	Q14003