Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone demethylase activity

RSBN1 KDM5D KDM5C

2.34e-0531363GO:0032452
GeneOntologyMolecularFunctionprotein demethylase activity

RSBN1 KDM5D KDM5C

2.58e-0532363GO:0140457
GeneOntologyMolecularFunctionhistone H3K4me/H3K4me2/H3K4me3 demethylase activity

KDM5D KDM5C

4.72e-056362GO:0034647
GeneOntologyMolecularFunctiondemethylase activity

RSBN1 KDM5D KDM5C

6.77e-0544363GO:0032451
GeneOntologyMolecularFunctionhistone H3K4 demethylase activity

KDM5D KDM5C

8.79e-058362GO:0032453
GeneOntologyMolecularFunctionunmethylated CpG binding

TLR9 MBD1

1.41e-0410362GO:0045322
GeneOntologyMolecularFunctionminor groove of adenine-thymine-rich DNA binding

POU3F4 PAX6

1.72e-0411362GO:0003680
GeneOntologyMolecularFunction2-oxoglutarate-dependent dioxygenase activity

RSBN1 KDM5D KDM5C

2.18e-0465363GO:0016706
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

POU1F1 POU2F2 PAX6 NFIB NFIC CREB5

4.51e-04560366GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

POU1F1 POU2F2 PAX6 NFIB NFIC CREB5

4.77e-04566366GO:0001216
GeneOntologyMolecularFunctiondioxygenase activity

RSBN1 KDM5D KDM5C

7.28e-0498363GO:0051213
GeneOntologyMolecularFunctionhistone H3 demethylase activity

KDM5D KDM5C

1.16e-0328362GO:0141052
GeneOntologyMolecularFunctionDNA secondary structure binding

POU3F4 PAX6

2.48e-0341362GO:0000217
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

POU1F1 POU2F2 POU3F4 RHOXF1 PAX6 NFIB NFIC CREB5

3.11e-031412368GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

POU1F1 POU2F2 POU3F4 RHOXF1 PAX6 NFIB NFIC CREB5

3.81e-031459368GO:0000977
GeneOntologyMolecularFunctioncore promoter sequence-specific DNA binding

PAX6 BAZ2A

4.42e-0355362GO:0001046
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

RSBN1 KDM5D KDM5C

5.09e-03194363GO:0016705
GeneOntologyCellularComponentchromatin

POU1F1 POU2F2 CHD8 POU3F4 RHOXF1 PAX6 KDM5D BAZ2A NFIB NFIC CREB5 KDM5C MBD1

3.60e-0714803513GO:0000785
MousePhenosubmandibular gland hypoplasia

PAX6 NFIB

4.14e-055292MP:0009522
MousePhenoabnormal cerebellar granule cell morphology

POU1F1 PAX6 NFIB

1.07e-0445293MP:0004098
MousePhenodecreased submandibular gland size

PAX6 NFIB

1.15e-048292MP:0009520
DomainPOU

POU1F1 POU2F2 POU3F4

3.04e-0616343SM00352
DomainPOU_2

POU1F1 POU2F2 POU3F4

3.04e-0616343PS00465
DomainPou

POU1F1 POU2F2 POU3F4

3.04e-0616343PF00157
DomainPOU_dom

POU1F1 POU2F2 POU3F4

3.04e-0616343IPR000327
DomainPOU_3

POU1F1 POU2F2 POU3F4

3.04e-0616343PS51179
DomainPOU_1

POU1F1 POU2F2 POU3F4

3.04e-0616343PS00035
DomainPOU

POU1F1 POU2F2 POU3F4

3.68e-0617343IPR013847
Domain-

POU1F1 POU2F2 POU3F4

1.56e-05273431.10.260.40
DomainCTF/NFI_DNA-bd_N

NFIB NFIC

1.93e-054342IPR019548
DomainNfI_DNAbd_pre-N

NFIB NFIC

1.93e-054342PF10524
DomainCTF_NFI

NFIB NFIC

1.93e-054342PF00859
DomainLys_sp_deMease-like_dom

KDM5D KDM5C

1.93e-054342IPR013637
DomainCTF/NFI_DNA-bd_CS

NFIB NFIC

1.93e-054342IPR019739
DomainCTF_NFI_1

NFIB NFIC

1.93e-054342PS00349
DomainCTF/NFI_DNA-bd-dom

NFIB NFIC

1.93e-054342IPR020604
DomainPLU-1

KDM5D KDM5C

1.93e-054342PF08429
DomainCTF/NFI

NFIB NFIC

1.93e-054342IPR000647
DomainCTF_NFI_2

NFIB NFIC

1.93e-054342PS51080
DomainLambda_DNA-bd_dom

POU1F1 POU2F2 POU3F4

1.95e-0529343IPR010982
DomainHomeobox_CS

POU1F1 POU2F2 POU3F4 RHOXF1 PAX6

2.04e-05186345IPR017970
Domainzf-C5HC2

KDM5D KDM5C

3.21e-055342PF02928
DomainZnf_C5HC2

KDM5D KDM5C

3.21e-055342IPR004198
DomainHomeobox

POU1F1 POU2F2 POU3F4 RHOXF1 PAX6

6.12e-05234345PF00046
DomainHOMEOBOX_1

POU1F1 POU2F2 POU3F4 RHOXF1 PAX6

6.37e-05236345PS00027
DomainHOX

POU1F1 POU2F2 POU3F4 RHOXF1 PAX6

6.50e-05237345SM00389
DomainHomeobox_dom

POU1F1 POU2F2 POU3F4 RHOXF1 PAX6

6.76e-05239345IPR001356
DomainHOMEOBOX_2

POU1F1 POU2F2 POU3F4 RHOXF1 PAX6

6.76e-05239345PS50071
Domain-

BAZ2A MBD1

8.95e-0583423.30.890.10
DomainJmjN

KDM5D KDM5C

1.43e-0410342PF02375
DomainJmjN

KDM5D KDM5C

1.43e-0410342SM00545
DomainJMJN

KDM5D KDM5C

1.43e-0410342PS51183
DomainJmjN

KDM5D KDM5C

1.43e-0410342IPR003349
Domain-

POU1F1 POU2F2 POU3F4 RHOXF1 PAX6

1.50e-042833451.10.10.60
DomainMethyl_CpG_DNA-bd

BAZ2A MBD1

1.75e-0411342IPR001739
DomainMBD

BAZ2A MBD1

1.75e-0411342PF01429
DomainMBD

BAZ2A MBD1

1.75e-0411342SM00391
DomainMBD

BAZ2A MBD1

1.75e-0411342PS50982
DomainDNA-bd_dom

BAZ2A MBD1

1.75e-0411342IPR016177
DomainMAD_homology1_Dwarfin-type

NFIB NFIC

2.10e-0412342IPR003619
DomainDWA

NFIB NFIC

2.10e-0412342SM00523
DomainMH1

NFIB NFIC

2.10e-0412342PF03165
DomainHomeodomain-like

POU1F1 POU2F2 POU3F4 RHOXF1 PAX6

3.14e-04332345IPR009057
Domain-

KDM5D KDM5C

3.33e-04153421.10.150.60
DomainARID

KDM5D KDM5C

3.33e-0415342PF01388
DomainBRIGHT

KDM5D KDM5C

3.33e-0415342SM00501
DomainARID_dom

KDM5D KDM5C

3.33e-0415342IPR001606
DomainARID

KDM5D KDM5C

3.33e-0415342PS51011
DomainPHD

KDM5D BAZ2A KDM5C

3.40e-0475343PF00628
DomainZnf_PHD-finger

KDM5D BAZ2A KDM5C

3.97e-0479343IPR019787
DomainPHD

KDM5D BAZ2A KDM5C

5.62e-0489343SM00249
DomainZnf_PHD

KDM5D BAZ2A KDM5C

6.00e-0491343IPR001965
DomainZF_PHD_2

KDM5D BAZ2A KDM5C

6.80e-0495343PS50016
DomainZF_PHD_1

KDM5D BAZ2A KDM5C

7.02e-0496343PS01359
DomainJmjC

KDM5D KDM5C

8.66e-0424342PF02373
DomainJMJC

KDM5D KDM5C

1.54e-0332342PS51184
DomainJmjC_dom

KDM5D KDM5C

1.54e-0332342IPR003347
DomainJmjC

KDM5D KDM5C

1.64e-0333342SM00558
DomainDNA/RNA_helicase_DEAH_CS

CHD8 DHX34

1.84e-0335342IPR002464
DomainDEAH_ATP_HELICASE

CHD8 DHX34

2.17e-0338342PS00690
DomainZnf_FYVE_PHD

KDM5D BAZ2A KDM5C

2.39e-03147343IPR011011
DomainZinc_finger_PHD-type_CS

KDM5D KDM5C

6.23e-0365342IPR019786
DomainIQ

IQCF3 IQCF1

7.39e-0371342PF00612
Domain-

MKRN3 KDM5D BAZ2A KDM5C

8.64e-034493443.30.40.10
DomainZnf_RING/FYVE/PHD

MKRN3 KDM5D BAZ2A KDM5C

9.32e-03459344IPR013083
DomainIQ

IQCF3 IQCF1

9.53e-0381342SM00015
PathwayPID_CDC42_PATHWAY

TNK2 PAX6 ARPC1B

1.93e-0470233M81
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

CHD8 PAX6 KDM5D BAZ2A KDM5C MBD1

1.34e-0815736630186101
Pubmed

NFI in the development of the olfactory neuroepithelium and the regulation of olfactory marker protein gene expression.

PAX6 NFIB NFIC

3.55e-08736310762365
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

POU1F1 POU2F2 POU3F4 RHOXF1 PAX6 NFIB NFIC CREB5

7.01e-0854436828473536
Pubmed

A census of human transcription factors: function, expression and evolution.

THAP2 POU1F1 POU2F2 POU3F4 RHOXF1 PAX6 NFIB NFIC CREB5

2.71e-0790836919274049
Pubmed

Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.

KDM5D KDM5C

1.04e-06236210441747
Pubmed

Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.

KDM5D KDM5C

1.04e-06236216416087
Pubmed

Identification of genes downstream of Pax6 in the mouse lens using cDNA microarrays.

EHBP1L1 PAX6

1.04e-06236211790784
Pubmed

Transcriptional diversity during lineage commitment of human blood progenitors.

NFIB NFIC

1.04e-06236225258084
Pubmed

Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.

KDM5D KDM5C

1.04e-06236232081420
Pubmed

Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.

KDM5D KDM5C

1.04e-0623629060413
Pubmed

A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.

KDM5D KDM5C

1.04e-0623627524912
Pubmed

Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism.

POU1F1 POU3F4 PAX6

1.55e-06223638934515
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

CHD8 PAX6 BAZ2A NFIB NFIC CREB5 MBD1

1.96e-0658336729844126
Pubmed

Sperm 1: a POU-domain gene transiently expressed immediately before meiosis I in the male germ cell.

POU1F1 POU2F2

3.12e-0633627902581
Pubmed

The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.

POU1F1 POU2F2

3.12e-0633622905684
Pubmed

Identification of a mouse male-specific transplantation antigen, H-Y.

KDM5D KDM5C

3.12e-0633627544442
Pubmed

Nuclear factor I transcription factors regulate IGF binding protein 5 gene transcription in human osteoblasts.

NFIB NFIC

3.12e-06336218809517
Pubmed

NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing.

NFIB NFIC

3.12e-0633629099724
Pubmed

PAX6 does not regulate Nfia and Nfib expression during neocortical development.

PAX6 NFIB

3.12e-06336226021864
Pubmed

Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord.

POU2F2 PAX6 NFIB

3.65e-062936330846445
Pubmed

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

KDM5D KDM5C MBD1

5.44e-063336326864203
Pubmed

Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.

KDM5D KDM5C

6.24e-06436216541399
Pubmed

NFIB-mediated repression of the epigenetic factor Ezh2 regulates cortical development.

PAX6 NFIB

6.24e-06436224553933
Pubmed

Nuclear factor one transcription factors as epigenetic regulators in cancer.

NFIB NFIC

6.24e-06436228076901
Pubmed

The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.

KDM5D KDM5C

6.24e-06436217320160
Pubmed

Transcription factor NF 1 expression in involuting mammary gland.

NFIB NFIC

6.24e-06436210959417
Pubmed

Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH.

NFIB NFIC

6.24e-0643627590749
Pubmed

RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin.

NFIB NFIC

6.24e-06436212624117
Pubmed

X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.

KDM5D KDM5C

6.24e-06436232732223
Pubmed

A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.

KDM5D KDM5C

6.24e-0643627951230
Pubmed

Altered expression of the developmentally regulated NFI gene family during phorbol ester-induced differentiation of human leukemic cells.

NFIB NFIC

6.24e-0643629052991
Pubmed

Expression patterns of the four nuclear factor I genes during mouse embryogenesis indicate a potential role in development.

NFIB NFIC

6.24e-0643629056636
Pubmed

Genomic organization, splice products and mouse chromosomal localization of genes for transcription factor Nuclear Factor One.

NFIB NFIC

6.24e-06436212568726
Pubmed

WNT signalling control by KDM5C during development affects cognition.

PAX6 KDM5C

1.04e-05536238383780
Pubmed

Regulation of the CYP3A4 and CYP3A7 promoters by members of the nuclear factor I transcription factor family.

NFIB NFIC

1.04e-05536219706729
Pubmed

Absence of the transcription factor Nfib delays the formation of the basilar pontine and other mossy fiber nuclei.

PAX6 NFIB

1.56e-05636219107796
Pubmed

Temporal control of a dendritogenesis-linked gene via REST-dependent regulation of nuclear factor I occupancy.

NFIB NFIC

1.56e-05636221270437
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

POU2F2 PAX6 KDM5D BAZ2A NFIB KDM5C MBD1

1.65e-0580836720412781
Pubmed

Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis.

POU1F1 POU3F4 PAX6

2.17e-055236323674600
Pubmed

TGF-β/NF1/Smad4-mediated suppression of ANT2 contributes to oxidative stress in cellular senescence.

NFIB NFIC

2.18e-05736225220407
Pubmed

SDF1/CXCR4 signalling regulates two distinct processes of precerebellar neuronal migration and its depletion leads to abnormal pontine nuclei formation.

PAX6 NFIB

2.18e-05736219429788
Pubmed

Brn-4 transcription factor expression targeted to the early developing mouse pancreas induces ectopic glucagon gene expression in insulin-producing beta cells.

POU3F4 PAX6

2.18e-05736211834725
Pubmed

POU homeodomain genes and myogenesis.

POU1F1 POU3F4

2.18e-0573628900043
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

POU3F4 RHOXF1 PAX6 KDM5D NFIC KDM5C MBD1

2.79e-0587736720211142
Pubmed

Bmp2 is required for cephalic neural tube closure in the mouse.

PAX6 NOG

2.91e-05836219097048
Pubmed

Reduced polyalanine-expanded Arx mutant protein in developing mouse subpallium alters Lmo1 transcriptional regulation.

PAX6 KDM5C

2.91e-05836224122442
Pubmed

The autism-associated protein CHD8 is required for cerebellar development and motor function.

CHD8 PAX6

3.73e-05936233826902
Pubmed

Transcriptional regulation of intermediate progenitor cell generation during hippocampal development.

PAX6 NFIB

3.73e-05936227965439
Pubmed

Nfix regulates fetal-specific transcription in developing skeletal muscle.

NFIB NFIC

5.70e-051136220178747
Pubmed

Transcriptomic analysis of murine embryos lacking endogenous retinoic acid signaling.

PAX6 CREB5

5.70e-051136223638021
Pubmed

Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1.

POU3F4 PAX6

6.83e-051236215882093
Pubmed

Relative roles of the different Pax6 domains for pancreatic alpha cell development.

POU3F4 PAX6

6.83e-051236220377917
Pubmed

Molecular basis of pituitary dysfunction in mouse and human.

POU1F1 PAX6

6.83e-051236211420609
Pubmed

Abrogation of protein convertase 2 activity results in delayed islet cell differentiation and maturation, increased alpha-cell proliferation, and islet neogenesis.

POU3F4 PAX6

6.83e-051236212933680
Pubmed

Dkk1 and noggin cooperate in mammalian head induction.

PAX6 NOG

6.83e-051236212952897
Pubmed

The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity.

POU3F4 PAX6

6.83e-051236215031110
Pubmed

A shared transcriptional code orchestrates temporal patterning of the central nervous system.

POU2F2 NFIB

6.83e-051236234767545
Pubmed

Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.

KDM5D KDM5C

8.07e-051336214660691
Pubmed

Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.

KDM5D KDM5C

8.07e-051336224619213
Pubmed

Nuclear factor I coordinates multiple phases of cerebellar granule cell development via regulation of cell adhesion molecules.

NFIB NFIC

8.07e-051336217553984
Pubmed

Sox2 and Pax6 maintain the proliferative and developmental potential of gliogenic neural stem cells In vitro.

POU3F4 PAX6

9.41e-051436221766338
Pubmed

Deletion of CHD8 in cerebellar granule neuron progenitors leads to severe cerebellar hypoplasia, ataxia, and psychiatric behavior in mice.

CHD8 PAX6

9.41e-051436235231638
Pubmed

Ikaros family proteins redundantly regulate temporal patterning in the developing mouse retina.

PAX6 NFIB

9.41e-051436236537580
Pubmed

Expression of human-specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility.

POU3F4 PAX6

9.41e-051436233938018
Pubmed

PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice.

POU3F4 PAX6

9.41e-051436223093780
Pubmed

Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif.

POU2F2 POU3F4

9.41e-051436217141158
Pubmed

Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.

KDM5D KDM5C

1.08e-041536214762062
Pubmed

Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage.

POU3F4 PAX6

1.24e-041636221880149
Pubmed

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.

POU3F4 PAX6

1.24e-04163629584121
Pubmed

Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.

POU3F4 PAX6

1.24e-041636210868931
Pubmed

Mucocutaneous inflammation in the Ikaros Family Zinc Finger 1-keratin 5-specific transgenic mice.

CHD8 PAX6

1.24e-041636228914974
Pubmed

Pax6 is implicated in murine pituitary endocrine function.

POU1F1 PAX6

1.24e-041636210451227
Pubmed

Conserved and Distinct Functions of the Autism-Related Chromatin Remodeler CHD8 in Embryonic and Adult Forebrain Neurogenesis.

CHD8 PAX6

1.24e-041636236127134
Pubmed

Excitatory neuronal CHD8 in the regulation of neocortical development and sensory-motor behaviors.

CHD8 PAX6

1.24e-041636233626347
Pubmed

Exon structure of the nuclear factor I DNA-binding domain from C. elegans to mammals.

NFIB NFIC

1.24e-041636210087299
Pubmed

Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain.

PAX6 NOG

1.24e-041636220730911
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

RSBN1 CHD8 TCHH DHX34 BAZ2A KDM5C MBD1

1.27e-04111636731753913
Pubmed

Nuclear factor one B regulates neural stem cell differentiation and axonal projection of corticofugal neurons.

PAX6 NFIB

1.40e-041736223749646
Pubmed

Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.

POU1F1 POU2F2 POU3F4 PAX6

1.56e-0426336420932939
Pubmed

Sex differences in sex chromosome gene expression in mouse brain.

KDM5D KDM5C

1.58e-041836212023983
Pubmed

The indirect role of fibroblast growth factor-8 in defining neurogenic niches of the olfactory/GnRH systems.

PAX6 NOG

1.58e-041836224336726
Pubmed

Expression of neurogenin3 reveals an islet cell precursor population in the pancreas.

POU3F4 PAX6

1.58e-041836210903178
Pubmed

Conditional deletion of Men1 in the pancreatic β-cell leads to glucagon-expressing tumor development.

POU3F4 PAX6

1.58e-041836225343275
Pubmed

MafB is required for islet beta cell maturation.

POU3F4 PAX6

1.58e-041836217360442
Pubmed

Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.

POU3F4 PAX6

1.76e-041936221852533
Pubmed

Gli3 is required for Emx gene expression during dorsal telencephalon development.

PAX6 NOG

1.76e-041936210409502
Pubmed

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite.

PAX6 NOG

1.76e-04193629585504
Pubmed

NEUROD1 Is Required for the Early α and β Endocrine Differentiation in the Pancreas.

POU3F4 PAX6

1.76e-041936234201511
Pubmed

Germline Chd8 haploinsufficiency alters brain development in mouse.

CHD8 PAX6

1.96e-042036228671691
Pubmed

The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3.

PAX6 KDM5C

1.96e-042036223637629
Pubmed

Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types.

POU1F1 POU3F4

2.16e-042136210367888
Pubmed

Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas.

POU3F4 PAX6

2.16e-042136219502415
Pubmed

Loss of the small GTPase Arl8b results in abnormal development of the roof plate in mouse embryos.

PAX6 NOG

2.16e-042136231038803
Pubmed

ISL1 controls pancreatic alpha cell fate and beta cell maturation.

POU3F4 PAX6

2.38e-042236236899442
Pubmed

The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine cell specification and postnatal β-cell maturation.

POU3F4 PAX6

2.38e-042236227993987
Pubmed

Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon.

POU3F4 PAX6

2.38e-042236211124115
Pubmed

Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex.

CHD8 PAX6

2.60e-042336237071993
Pubmed

Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development.

POU3F4 PAX6

2.60e-042336210588713
Pubmed

Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development.

MKRN3 NFIB

3.08e-042536230718509
Pubmed

Dentate gyrus morphogenesis is regulated by β-catenin function in hem-derived fimbrial glia.

PAX6 NFIB

3.08e-042536236196585
InteractionSOX3 interactions

PAX6 NFIC ARPC1B

4.19e-0618363int:SOX3
Cytoband3p21.2

IQCF3 IQCF1

1.01e-04193623p21.2
CytobandEnsembl 112 genes in cytogenetic band chr3p21

TLR9 IQCF3 IQCF1 USP19

1.09e-04316364chr3p21
Cytoband7q22.1

PILRA ARPC1B

3.58e-031133627q22.1
GeneFamilyPOU class homeoboxes and pseudogenes

POU1F1 POU2F2 POU3F4

2.73e-0623223523
GeneFamilyZinc fingers CXXC-type|Methyl-CpG binding domain containing

BAZ2A MBD1

7.72e-05112221025
GeneFamilyAT-rich interaction domain containing

KDM5D KDM5C

1.47e-0415222418
GeneFamilyPHD finger proteins

KDM5D BAZ2A KDM5C

1.72e-049022388
GeneFamilyPHD finger proteins|Lysine demethylases

KDM5D KDM5C

3.84e-0424222485
GeneFamilyPRD class homeoboxes and pseudogenes

RHOXF1 PAX6

5.54e-0392222521
CoexpressionMARTINEZ_RB1_TARGETS_DN

POU1F1 TCHH PAX6 TMEM109 PILRA NFIB USP19

1.06e-05569367M12701
CoexpressionMARTINEZ_RB1_TARGETS_DN

POU1F1 TCHH PAX6 TMEM109 PILRA NFIB USP19

2.04e-05630367MM1038
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

POU2F2 EHBP1L1 PILRA ARPC1B

1.67e-05191364b5715eeb72a97b7bc87b83f6c289e225f58da842
ToppCellnucseq-Immune-Immune_Myeloid-pMON-pMON|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

POU2F2 EHBP1L1 PILRA ARPC1B

1.77e-05194364e237384b02be460d44eeada3026a5691c66f6fc1
ToppCellnucseq-Immune-Immune_Myeloid-pMON|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

POU2F2 EHBP1L1 PILRA ARPC1B

1.77e-051943640bc83ae79873a5e473e6e1e3111924cd003986a1
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

POU2F2 EHBP1L1 PILRA CROCC2

1.81e-051953641d58585557bf8e9ce4d514e128d3a902b526331d
ToppCellAdult-Immune-monocyte|Adult / Lineage, Cell type, age group and donor

POU2F2 EHBP1L1 PILRA CREB5

1.84e-051963643ef193c5180de3137daf886492e74fc574bc9767
ToppCellAdult-Immune-monocyte-D122|Adult / Lineage, Cell type, age group and donor

POU2F2 EHBP1L1 PILRA CREB5

1.84e-0519636416b0acb6157534938ca83d4e909471e33a7d3c52
ToppCellImmune-monocyte|World / Lineage, Cell type, age group and donor

POU2F2 EHBP1L1 PILRA CREB5

1.92e-05198364d3622da252fd580f1dc5c7478a8e23df5ec083cf
ToppCellkidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

POU2F2 EHBP1L1 PILRA ARPC1B

1.96e-0519936487c7b8c77c28f3cfa6d6dddfd00c9d18d116207e
ToppCellwk_08-11-Hematologic-Myeloid|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

TMC8 POU2F2 PILRA ARPC1B

2.00e-05200364148e09e27e4a563bdd1fbe9a593cd938885cbb1b
ToppCellBronchial-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD14|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

POU2F2 EHBP1L1 PILRA CREB5

2.00e-052003645432bdf495431cd26f6e4cd585100f3652588913
ToppCellBronchial-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD16|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

POU2F2 EHBP1L1 PILRA CROCC2

2.00e-05200364fc061de0db2e8b5ca47f5e2a1e861018e7f1b582
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Neuron|GW16 / Sample Type, Dataset, Time_group, and Cell type.

POU3F4 PAX6 NFIB

1.53e-0412936364768adf23123b92280fb30eb85147cbee084ae0
ToppCellTCGA-Blood_and_Bone_Marrow-Primary_Blood_Derived_Cancer_-_Peripheral_Blood-Leukemia-Acute_Myeloid_Leukemia-3|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9

EHBP1L1 PILRA CREB5

1.79e-041363634f5e0b6c7d6e3e922af4daa7c3eb56490455c1df
ToppCellP07-Hematopoietic-Immune-immune_cell_unspecified|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MREG POU2F2 PILRA

2.12e-04144363eb057dbdb2a5a2d29b93e5ed5479a3fd1bf3fd26
ToppCellP07-Hematopoietic-Immune|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MREG POU2F2 PILRA

2.12e-04144363962698c5c15bd583fccda0593b7aab5f2eb4bc9f
ToppCellLPS-IL1RA-Myeloid-Dendritic_cells-Monocytes-Macrophages|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

POU2F2 CLCN4 PILRA

2.35e-04149363a464c0fd54e3c9e1d40d95b49489cb9371dd7c24
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TMC8 POU2F2 KDM5D

2.39e-0415036353de595376a9fc92491dfd58ff25938b0bf79903
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TMC8 POU2F2 KDM5D

2.39e-04150363e4b40b3243ed26d0c46bf196ac06e148834e7ed2
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(NPW+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

POU3F4 PAX6 RGL3

2.63e-04155363498e52e2364ff44d3c0c707ba22468217031f5bd
ToppCelldroplet-Kidney-KIDNEY-30m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 PILRA CREB5

2.68e-041563636e60e860603a7e8194f437a574ff8e887f6083b8
ToppCellfacs-Lung-EPCAM-3m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMC8 POU2F2 PILRA

2.79e-04158363b0508a600994090c6aafd8d779437190a33ad821
ToppCellfacs-Lung-3m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l4|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

POU2F2 EHBP1L1 PILRA

2.79e-041583637bd4a64a610eb1cbcd3d07ea5258a55107cf6c00
ToppCellfacs-Lung-3m-Hematologic-myeloid-intermediate_monocyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

POU2F2 EHBP1L1 PILRA

2.79e-04158363b35bab2b93d0af821bfae18a358eb7dddaf3860f
ToppCellfacs-Lung-EPCAM-3m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMC8 POU2F2 PILRA

2.79e-04158363a816cc095452308d06f87b77467e2a8c6361fd2a
ToppCellfacs-Lung-Endomucin-24m-Myeloid|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 PILRA ARPC1B

2.84e-04159363886cbaef39a3517514a3896b6b960d01a3af043d
ToppCellnormal_Pleural_Fluid-B_lymphocytes-Undetermined|normal_Pleural_Fluid / Location, Cell class and cell subclass

POU2F2 PAX6 TLR9

2.89e-041603635744cd30709f38e84f7ec8893dc19d7a288b465a
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMC8 POU2F2 TLR9

2.89e-04160363cfd005e98944817458e8ef9e0c436d77f50c1ad1
ToppCellfacs-Kidney-nan-24m-Myeloid-macrophage|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 PILRA CREB5

3.16e-04165363a359dda24c2c10b7b8df902a7c4c2ebf27b041f3
ToppCellfacs-Kidney-nan-24m-Myeloid-macrophage|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 PILRA CREB5

3.16e-041653631d5880aa49e6e6e95bde14a40fbe6e40b71c6d22
ToppCellPND14-Immune-Immune_Myeloid|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EHBP1L1 PILRA ARPC1B

3.16e-04165363e37d00084f58fbd25f66ee65be510c030167084e
ToppCellfacs-Kidney-nan-24m-Myeloid|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 PILRA CREB5

3.16e-04165363cdc09cbfd6eaeb8e436d83bbca7146bde3b3f01e
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Tac1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MKRN3 NOG CREB5

3.22e-0416636359d47c1fca7a8c70f6998f3367a9dbcb9b67966f
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Macrophage-macrophage,_alveolar|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

POU3F4 PILRA CREB5

3.22e-0416636328a44448a0b0d72459e8fe84ce5d666f16f514b3
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Macrophage|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

POU3F4 PILRA CREB5

3.22e-041663632a04915d534a83e65aa168435d6856125b5bdd78
ToppCelldroplet-Kidney-nan-24m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 PILRA ARPC1B

3.28e-041673632ee1660be117e20f24557522345572d11cbee813
ToppCellSmart-seq2-blood_(Smart-seq2)|Smart-seq2 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

POU2F2 EHBP1L1 ARPC1B

3.39e-041693630ee74cc97a2db9cc16dc73424f74747afe13af90
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

POU2F2 PILRA ARPC1B

3.39e-041693631077fbca61bd0c1f9706aeb0552b77362127f261
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

POU2F2 PILRA ARPC1B

3.39e-0416936370c841a7b1e3f665105d715a6d72762c80ce5de2
ToppCellfacs-Liver-Non-hepatocytes-24m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 PILRA ARPC1B

3.39e-041693632d3618f78484bd3508b7bdae3a0d0183cdae5057
ToppCellfacs-Liver-Non-hepatocytes-24m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 PILRA ARPC1B

3.45e-04170363f08aa6168ff0c20b2083dbf588dd3294e3d9580e
ToppCellMonocytes-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

POU2F2 EHBP1L1 CREB5

3.45e-041703634e93b66b3033e6e4d5f6d2f41974623a53108f5e
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

POU2F2 PILRA ARPC1B

3.51e-0417136392cd1d7ec5bc0a77f81b915d237fac4075ba01e3
ToppCell3'_v3-bone_marrow-Lymphocytic_B-ABC_aged-B_naive|bone_marrow / Manually curated celltypes from each tissue

POU2F2 TLR9 CLCN4

3.51e-04171363fcc31a9a69f96de10d1324a5a4fbfe4289bf4984
ToppCelldroplet-Lung-1m-Hematologic-myeloid-non-classical_monocyte|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

POU2F2 PILRA ARPC1B

3.51e-0417136300739085fdbc4d64c9faacba2c2adeab580dd2b1
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

POU2F2 EHBP1L1 PILRA

3.57e-041723634b1d4920f121d063784133969a797c05eb7feaa2
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EHBP1L1 PILRA ARPC1B

3.57e-04172363e72966ced5f2ee9e24ce9fd820d99a69a482a607
ToppCelldroplet-Lung-1m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

POU2F2 PILRA ARPC1B

3.57e-041723635f58ff6cac32546d07b2a49ed250b6c7aa417188
ToppCellfacs-Liver-Non-hepatocytes-24m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 PILRA ARPC1B

3.57e-0417236366823536288c7009ce01b5177794a3e874e94570
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EHBP1L1 PILRA ARPC1B

3.57e-0417236383730ea3b240b8e2f2a9fb6c34dd1408050867ff
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 TLR9 CREB5

3.63e-04173363e944ea3a0a368f856efacbda4600605cf751dd9c
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

POU2F2 PILRA ARPC1B

3.63e-041733636d29e142d043dfd1ed442812358ac463b63b5e3f
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 TLR9 CREB5

3.63e-0417336385fa5918e9c1f6bb4757e3350cfc71ee75c55640
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMC8 POU2F2 PILRA

3.63e-041733630a0127bcb1d7b2b6125faef576dd843055095528
ToppCellPND07-Immune|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

POU2F2 PILRA ARPC1B

3.82e-041763632f87f49b64c6f89823d540172a8e923ebaa6d6cd
ToppCellfacs-Lung-3m-Hematologic|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

POU2F2 PILRA ARPC1B

3.88e-04177363a8a7b135d86701ab9acac8273061debf8cce79a0
ToppCell3'-GW_trimst-1.5-LargeIntestine-Hematopoietic-Myeloid-cDC2|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMC8 POU2F2 PILRA

4.01e-04179363ce95b601bf17ae8167d382a105384b9e65e9407f
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

EHBP1L1 TCHH ARPC1B

4.01e-041793633d3716078afdb9a89ddfadb3197cd1b52fa770be
ToppCell3'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Monocytes|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

POU2F2 PILRA ARPC1B

4.15e-04181363bad77767e64cc093a827a6b0f3f401f3f108e457
ToppCellwk_08-11-Hematologic-Myeloid-APOE+_Mac2|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

TMC8 TCHH PILRA

4.42e-041853638f843badc0e26cb7300c83db56c7974beb90fcf3
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

POU3F4 TCHH ARPC1B

4.42e-04185363a6874dd3030d04380cc3c01de1069461aad4ef45
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TCHH PILRA ARPC1B

4.49e-04186363e4de270d38bbed022f545bd0bbaa9599e707ec87
ToppCellproximal-3-Hematologic-Myeloid_Dendritic_Type_1|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MREG POU2F2 CLCN4

4.49e-04186363c920dffd24f051b54d8b48f801fffc928d99e135
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-B_cells-Immature_B|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

POU2F2 TLR9 ARPC1B

4.49e-04186363459a7e97bbac2b2cd253aa4ab38d0e4ae6191e8b
ToppCellproximal-Hematologic-Myeloid_Dendritic_Type_1-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MREG POU2F2 CLCN4

4.49e-04186363d740aca5dc4240851ba7bc5988c0970d785ad0c2
ToppCellwk_08-11-Hematologic-Myeloid-Cycling_DC|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

POU2F2 PILRA ARPC1B

4.49e-04186363de1f0bc5dbf6dc0e716f5ebbf2bbcfe249811c54
ToppCellproximal-Hematologic-Myeloid_Dendritic_Type_1|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MREG POU2F2 CLCN4

4.49e-041863634ca7f6c043874a0c536f75af5ca24c7c66725e54
ToppCell5'-Adult-LymphNode-Hematopoietic-Myeloid-Macrophages|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PAX6 PILRA ARPC1B

4.56e-0418736300930e407beaa337f72533a69f32d150faad8b9a
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-cDC2|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

POU2F2 PILRA ARPC1B

4.63e-04188363c7c2cf1aa328e735073d6031e44b5dbd55beae6d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TMC8 POU2F2 PILRA

4.63e-041883634e27ada1bda88811b73376c8a6136cbfc83bfdb9
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-Myeloid-Monocytes|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

POU2F2 PILRA ARPC1B

4.63e-04188363085b61dfad373e5c39f2496539fbfed1b588115a
ToppCellMonocytes-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

POU2F2 ARPC1B CREB5

4.63e-04188363756375cf9c9cccc4fb4a7f5e4756fa3fc36a7892
ToppCellwk_08-11-Hematologic-Myeloid-S100A12-hi_cla._mono.|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

POU2F2 PILRA ARPC1B

4.78e-04190363b8c131020d20005cd9f23d26312196f62c958074
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-B_cells|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

POU2F2 TLR9 ARPC1B

4.78e-04190363e1af324b4522045875fb64766cf118cd7b41704a
ToppCellcritical-Lymphoid-B_cell|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

TMC8 POU2F2 TMEM109

4.85e-041913630716cfaeb11d9c90c18fa8f9d50c9c6fb5182848
ToppCellAdult-Immune-monocyte-D175|Adult / Lineage, Cell type, age group and donor

POU2F2 EHBP1L1 CREB5

4.85e-04191363cbebb4d9550fdcd606cb3685ac9546c6b73fd422
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMC8 POU2F2 PILRA

4.85e-04191363c72e62cf5b45c04ee5e7719db31f917c4f76b1e4
ToppCell3'_v3-blood-Myeloid_Monocytic-Nonclassical_monocytes|blood / Manually curated celltypes from each tissue

POU2F2 PILRA CROCC2

4.85e-0419136344a797b39254cbfa5c2bad8155436adfd3019bb0
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PRRG1 CLCN4 CREB5

4.92e-041923638dc3016601148243196e925641c9507e9d58c9e0
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-T_cells-Treg|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMC8 POU2F2 ARPC1B

5.00e-04193363f3eb295a019de29f484964f00ea436860af249a5
ToppCell3'_v3-bone_marrow-Myeloid_Monocytic-Nonclassical_monocytes|bone_marrow / Manually curated celltypes from each tissue

POU2F2 PILRA CROCC2

5.00e-04193363dc309c249d569e93dc2b154e002212a6eee44497
ToppCellChildren_(3_yrs)-Immune-monocyte-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

POU2F2 PILRA CREB5

5.00e-0419336358e1930a1d80ad3729ab9604ac8ebf7308232a3d
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

POU2F2 PILRA ARPC1B

5.00e-04193363fc2eb6a7b4f1e687bf37e59e3cd52b14f99ffea4
ToppCellfacs-Skin-Anagen-3m-Epithelial-bulge_keratinocyte|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOG NFIB CREB5

5.00e-04193363eba3c70701b051bc1ed1f4db9270cb27a77ffc3e
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

POU2F2 EHBP1L1 CREB5

5.00e-041933631db487e5f81849740d57cc3e2b5739e8f7581efb
ToppCellCOPD-Myeloid-ncMonocyte|COPD / Disease state, Lineage and Cell class

POU2F2 PILRA DHX34

5.00e-04193363936ca95995599356b794fba32bfd82d8de339365
ToppCellwk_20-22-Hematologic-Myeloid-DC3|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

POU2F2 PILRA ARPC1B

5.00e-0419336312d1e7ed0bcd1259d6dc8ae962aad69586e5d26b
ToppCellwk_08-11-Hematologic-Myeloid-CX3CR1+_Mac|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

POU2F2 PILRA ARPC1B

5.00e-04193363afc20433b5abc9b430751a2aa8d93b0fd136a888
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NFIB NFIC CREB5

5.08e-041943638b81f039f5b25d35a4d5a41b27d4d9360ba22f15
ToppCellmild-Myeloid-Neutrophils_1|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PILRA DHX34 CREB5

5.08e-04194363ccd911ce3251cd1c60f1fb2ce00650fbe7a379bb
ToppCellCOVID_non-vent-Myeloid-Monocytic-CD16+_Monocyte|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

POU2F2 EHBP1L1 PILRA

5.08e-041943631b4a17d58793e8889484fe592dce8ee1e8fe77a9
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TMC8 POU2F2 TNK2

5.08e-041943634dfc890bacf133cfb6ec7c8b73f084f2491cf78e
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNK2 NFIB CREB5

5.08e-041943630ef63abcfd057079a9a6f8b27404ff521d44845d
ToppCellhealthy_donor-Myeloid-Monocytic-CD16+_Monocyte|healthy_donor / Disease condition, Lineage, Cell class and subclass

POU2F2 EHBP1L1 PILRA

5.08e-04194363ecf746ef1c5c4d6d9ca06a6d3e3778670b5700c2
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

POU2F2 TMEM109 CREB5

5.08e-04194363e56c6e5c9b7d287ae94566b561e21cec2055f83d
ToppCelldroplet-Tongue-nan-3m-Epithelial-basal_cell|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFIB ARPC1B CREB5

5.08e-041943631eef012e53e43c4f4f6968baac3cc28727c4a9b5
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-Macrophages|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TCHH PILRA ARPC1B

5.08e-0419436344a90be1d2b2ae08f8c523bee65dd1e536ec0f95
ToppCellHealthy-Classical_Monocyte|World / disease group, cell group and cell class

POU2F2 PILRA CREB5

5.15e-041953630d96f456cc84ebb2543406fb2374c6d7cedd3c4d
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

POU2F2 TMEM109 CREB5

5.15e-0419536385fee07d71c0393ea42bcf1130566dff4a62f507
ToppCellCF-Myeloid|CF / Disease state, Lineage and Cell class

PILRA DHX34 CREB5

5.15e-04195363ecf604de496f389a49429d0bb211e1db6019cc8b
ToppCellmetastatic_Brain-Myeloid_cells-Microglia/Mac|metastatic_Brain / Location, Cell class and cell subclass

THAP2 TCHH PILRA

5.15e-04195363ae48d493ebda5f87781181a3d1d73d8f84fc5e77
DrugCapsaicin [404-86-4]; Up 200; 13uM; MCF7; HT_HG-U133A

MKRN3 POU1F1 POU2F2 PILRA CREB5

1.33e-051953655673_UP
DrugSC 19220; Up 200; 10uM; MCF7; HT_HG-U133A

DHX34 NFIB KDM5C USP19 MBD1

1.33e-051953657060_UP
Drug(S)-(-)-Cycloserine [339-72-0]; Down 200; 39.2uM; MCF7; HT_HG-U133A

TNK2 EHBP1L1 DHX34 BAZ2A NFIB

1.47e-051993654346_DN
DrugAC1MQJ8M

TNK2 KDM5D

1.88e-0413362CID003477614
Drug7-biopterin

NFIB NFIC

1.88e-0413362CID005488923
DrugL 230

KDM5D MBD1

1.88e-0413362CID000737171
DrugClomiphene citrate (Z,E) [50-41-9]; Up 200; 6.6uM; MCF7; HT_HG-U133A

MKRN3 POU2F2 CLCN4 BAZ2A

1.99e-041843644994_UP
DrugSparteine (-) [90-39-1]; Down 200; 17uM; MCF7; HT_HG-U133A

EHBP1L1 DHX34 BAZ2A NFIB

2.20e-041893642790_DN
DrugPipenzolate bromide [125-51-9]; Up 200; 9.2uM; MCF7; HT_HG-U133A

TCHH DHX34 BAZ2A NFIB

2.34e-041923643460_UP
DrugSulfameter [651-06-9]; Down 200; 14.2uM; PC3; HT_HG-U133A

DHX34 BAZ2A NFIB CREB5

2.43e-041943645732_DN
DrugAC1L1C6C

POU1F1 POU2F2 POU3F4

2.45e-0477363CID000001759
DrugBenperidol [2062-84-2]; Up 200; 10.4uM; MCF7; HT_HG-U133A

POU1F1 TNK2 DHX34 MBD1

2.48e-041953644781_UP
DrugButylparaben [94-26-8]; Down 200; 20.6uM; MCF7; HT_HG-U133A

FBXL12 TNK2 DHX34 NFIB

2.48e-041953645245_DN
DrugHexestrol [84-16-2]; Up 200; 14.8uM; HL60; HT_HG-U133A

POU1F1 TNK2 CLCN4 DHX34

2.53e-041963642515_UP
DrugRetinoic acid [302-79-4]; Down 200; 13.4uM; PC3; HT_HG-U133A

EHBP1L1 DHX34 BAZ2A NFIB

2.53e-041963645767_DN
DrugBretylium tosylate [61-75-6]; Up 200; 9.6uM; MCF7; HT_HG-U133A

POU2F2 TNK2 POU3F4 BAZ2A

2.53e-041963643394_UP
DrugSulfaguanidine [57-67-0]; Up 200; 18.6uM; MCF7; HT_HG-U133A

POU2F2 TNK2 TCHH MBD1

2.53e-041963641495_UP
DrugPentamidine isethionate [140-64-7]; Down 200; 6.8uM; HL60; HT_HG-U133A

MREG CLCN4 PILRA BAZ2A

2.53e-041963642473_DN
DrugL(-)-vesamicol hydrochloride [112709-59-8]; Down 200; 13.6uM; HL60; HT_HG-U133A

TNK2 CLCN4 PILRA DHX34

2.53e-041963643118_DN
DrugNialamide [51-12-7]; Up 200; 13.4uM; MCF7; HT_HG-U133A

POU3F4 PAX6 BAZ2A NFIB

2.53e-041963644347_UP
DrugHexestrol [84-16-2]; Down 200; 14.8uM; MCF7; HT_HG-U133A

PRRG1 EHBP1L1 TCHH NFIB

2.58e-041973646077_DN
DrugEthambutol dihydrochloride [1070-11-7]; Up 200; 14.4uM; MCF7; HT_HG-U133A

POU2F2 CLCN4 DHX34 NFIB

2.58e-041973644120_UP
DrugGuanabenz acetate [23256-50-0]; Up 200; 13.8uM; MCF7; HT_HG-U133A

BAZ2A CREB5 KDM5C MBD1

2.58e-041973645703_UP
DrugIndoprofen [31842-01-0]; Down 200; 14.2uM; MCF7; HT_HG-U133A

TNK2 EHBP1L1 BAZ2A NFIB

2.58e-041973644832_DN
DrugPiperidolate hydrochloride [129-77-1]; Up 200; 11.2uM; MCF7; HT_HG-U133A

TNK2 EHBP1L1 CLCN4 MBD1

2.58e-041973646772_UP
DrugAcyclovir [59277-89-3]; Down 200; 17.8uM; MCF7; HT_HG-U133A

POU2F2 EHBP1L1 DHX34 BAZ2A

2.58e-041973645643_DN
Drughaloperidol; Up 200; 10uM; MCF7; HT_HG-U133A

POU2F2 EHBP1L1 DHX34 NFIB

2.58e-041973641669_UP
DrugOxyphenbutazone [129-20-4]; Down 200; 12.4uM; PC3; HT_HG-U133A

TNK2 DHX34 BAZ2A NFIC

2.58e-041973644506_DN
DrugFlunisolide [3385-03-3]; Down 200; 9.2uM; MCF7; HT_HG-U133A

EHBP1L1 DHX34 BAZ2A USP19

2.63e-041983646023_DN
DrugMK-886; Up 200; 1uM; MCF7; HG-U133A

TNK2 KDM5D CLCN4 DHX34

2.63e-04198364264_UP
DrugHydroxyzine dihydrochloride [2192-20-3]; Up 200; 9uM; MCF7; HT_HG-U133A

POU2F2 DHX34 BAZ2A NFIB

2.63e-041983645006_UP
DrugGelsemine [509-15-9]; Down 200; 12.4uM; HL60; HT_HG-U133A

TNK2 DHX34 BAZ2A USP19

2.63e-041983642162_DN
DrugBethanechol chloride [590-63-6]; Up 200; 20.4uM; MCF7; HT_HG-U133A

MKRN3 POU2F2 TNK2 BAZ2A

2.63e-041983643537_UP
DrugSulfasalazine [599-79-1]; Up 200; 10uM; PC3; HT_HG-U133A

POU2F2 CLCN4 BAZ2A NFIB

2.63e-041983646346_UP
DrugPicrotoxinin [17617-45-7]; Down 200; 13.6uM; MCF7; HT_HG-U133A

EHBP1L1 DHX34 NFIB NFIC

2.63e-041983642816_DN
DrugIopamidol [60166-93-0]; Down 200; 5.2uM; MCF7; HT_HG-U133A

DHX34 BAZ2A NFIB NFIC

2.63e-041983647189_DN
DrugMonocrotaline [315-22-0]; Up 200; 12.2uM; MCF7; HT_HG-U133A

TNK2 POU3F4 CLCN4 MBD1

2.68e-041993646771_UP
DrugBenzydamine hydrochloride [132-69-4]; Up 200; 11.6uM; PC3; HT_HG-U133A

POU2F2 EHBP1L1 BAZ2A NFIB

2.68e-041993645811_UP
DrugTetrandrine [518-34-3]; Down 200; 6.4uM; PC3; HT_HG-U133A

DHX34 NFIB NFIC KDM5C

2.68e-041993645821_DN
DrugDacarbazine [4342-03-4]; Down 200; 22uM; MCF7; HT_HG-U133A

TNK2 DHX34 BAZ2A NFIB

2.68e-041993642754_DN
DrugTiapride hydrochloride [51012-33-0]; Down 200; 11uM; HL60; HT_HG-U133A

DHX34 BAZ2A NFIC KDM5C

2.68e-041993642331_DN
DrugAcetazolamide [59-66-5]; Down 200; 18uM; PC3; HT_HG-U133A

DHX34 BAZ2A KDM5C USP19

2.68e-041993641808_DN
DrugSulfabenzamide [127-71-9]; Up 200; 14.4uM; PC3; HT_HG-U133A

POU1F1 CLCN4 DHX34 KDM5C

2.68e-041993646634_UP
Diseasesyndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)

KDM5D KDM5C

8.19e-064352DOID:0060809 (implicated_via_orthology)
DiseaseMacrocephaly

CHD8 NFIB

7.47e-0511352C0221355
Diseasesyndromic intellectual disability (implicated_via_orthology)

KDM5D KDM5C

1.62e-0416352DOID:0050888 (implicated_via_orthology)
DiseaseMental Retardation, Psychosocial

CHD8 PAX6 KDM5C

6.00e-04139353C0025363
DiseaseProfound Mental Retardation

CHD8 PAX6 KDM5C

6.00e-04139353C0020796
DiseaseMental deficiency

CHD8 PAX6 KDM5C

6.00e-04139353C0917816
Diseaseautism spectrum disorder (implicated_via_orthology)

CHD8 KDM5D KDM5C

7.77e-04152353DOID:0060041 (implicated_via_orthology)
Diseasecup-to-disc ratio measurement

EHBP1L1 PAX6 CROCC2 CREB5

1.63e-03430354EFO_0006939

Protein segments in the cluster

PeptideGeneStartEntry
RREKQQRWTRREQTD

CHD8

1791

Q9HCK8
IRVWRQTLERCRSAA

BAZ2A

1641

Q9UIF9
VILRINRAARCVRWA

ARPC1B

91

O15143
RCNIAWCRRRKTTRL

CLCN4

351

P51793
QRRLWEAVKRRKALC

TNK2

56

Q07912
PVQEQRARWERKRAC

ARHGEF39

11

Q8N4T4
RRIDCLRQADKVWRL

NFIB

116

O00712
LQSQARMWRIRRRYC

IQCF1

131

Q8N6M8
RMWRIRRRYCQVLNA

IQCF1

136

Q8N6M8
RRAKWRREEKLRNQR

PAX6

261

P26367
RAAATRCRQKRKVWV

CREB5

386

Q02930
EAICKDRRWARVAQR

KDM5D

126

Q9BY66
LRRQWKCVQRRCLRG

MBD1

251

Q9UIS9
VVVWTRRNRRICSKA

EHBP1L1

41

Q8N3D4
IRVWFCNRRQKEKRI

POU2F2

341

P09086
AQRLEKWIRIAQRCR

RGL3

321

Q3MIN7
KWIRIAQRCRELRNF

RGL3

326

Q3MIN7
WWRTLVQRRIRQRRQ

IQCF3

66

P0C7M6
VVRVWFCNRRQKEKR

POU3F4

321

P49335
CLLRWRRRKGQQRTK

PILRA

216

Q9UKJ1
RRWRREQELCLQLKS

CROCC2

411

H7BZ55
KSERSRNSRKWCRRR

DHX34

656

Q14147
KSVHLTVLRWRCQRR

NOG

196

Q13253
RRTADKWRAEERLQC

RSBN1

6

Q5VWQ0
KVRVWFKNKRARCRR

RHOXF1

146

Q8NHV9
EVVRVWFCNRRQREK

POU1F1

256

P28069
TLRQVRREVRNRWKC

MREG

96

Q8N565
RREVRNRWKCILEDL

MREG

101

Q8N565
VRDRIRISRVCHRWK

FBXL12

21

Q9NXK8
RRIDCLRQADKVWRL

NFIC

116

P08651
SRIDICLRKRQSQRW

USP19

366

O94966
LRWQRWQRRRQTVER

TMC8

61

Q8IU68
IRCIRRWRSARQFEN

MKRN3

341

Q13064
VRLRQRLCRQSVLLW

TLR9

981

Q9NR96
RQVEELRWRQRRAAK

TMEM109

221

Q9BVC6
IWRCFLRNKTRRQTV

PRRG1

101

O14668
RRKEWVRLVRRKNFV

THAP2

31

Q9H0W7
ERRRSQEQRRDQKWR

TCHH

861

Q07283
EAICKDRRWARVAQR

KDM5C

126

P41229