Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion binding	LRP1 LRP2 FBN1 CELSR2 PKD1L3 NOTCH1 CRB1 ADGRL4	3.23e-06	749	26	8	GO:0005509
GeneOntologyMolecularFunction	insulin-like growth factor I binding	LRP2 ITGB4	1.26e-04	13	26	2	GO:0031994
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor activity	LRP1 LRP2	1.93e-04	16	26	2	GO:0005041
GeneOntologyMolecularFunction	insulin-like growth factor binding	LRP2 ITGB4	2.75e-04	19	26	2	GO:0005520
GeneOntologyMolecularFunction	lipoprotein particle receptor activity	LRP1 LRP2	3.37e-04	21	26	2	GO:0030228
GeneOntologyMolecularFunction	semaphorin receptor binding	SEMA5B PLXNB1	4.06e-04	23	26	2	GO:0030215
GeneOntologyMolecularFunction	lipoprotein particle receptor binding	LRP1 LRP2	1.17e-03	39	26	2	GO:0070325
GeneOntologyMolecularFunction	integrin binding	LAMB2 FBN1 ITGB4	1.48e-03	175	26	3	GO:0005178
GeneOntologyMolecularFunction	extracellular matrix structural constituent	LAMB2 FBN1 MUC2	1.82e-03	188	26	3	GO:0005201
GeneOntologyMolecularFunction	cargo receptor activity	LRP1 LRP2	5.45e-03	85	26	2	GO:0038024
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	ADRB2 CELSR2 PKD1L3 NOTCH1 PLXNB1 ADGRL4	6.80e-03	1353	26	6	GO:0004888
GeneOntologyMolecularFunction	amyloid-beta binding	LRP1 ADRB2	7.75e-03	102	26	2	GO:0001540
GeneOntologyBiologicalProcess	cell morphogenesis	LRP1 LRP2 LAMB2 UNK EPS8 CELSR2 SEMA5B NOTCH1 PLXNB1 CRB1	9.21e-07	1194	26	10	GO:0000902
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	LRP1 LRP2 LAMB2 UNK CELSR2 SEMA5B NOTCH1 PLXNB1	2.52e-06	748	26	8	GO:0048667
GeneOntologyBiologicalProcess	gliogenesis	LRP1 LRP2 LAMB2 ITGB4 NOTCH1 CRB1	1.37e-05	435	26	6	GO:0042063
GeneOntologyBiologicalProcess	positive regulation of lysosomal protein catabolic process	LRP1 LRP2	1.52e-05	5	26	2	GO:1905167
GeneOntologyBiologicalProcess	chemoattraction of axon	LRP1 LRP2	1.52e-05	5	26	2	GO:0061642
GeneOntologyBiologicalProcess	axon extension involved in regeneration	LRP1 LAMB2	1.52e-05	5	26	2	GO:0048677
GeneOntologyBiologicalProcess	sprouting of injured axon	LRP1 LAMB2	2.28e-05	6	26	2	GO:0048682
GeneOntologyBiologicalProcess	axon guidance	LRP1 LRP2 LAMB2 SEMA5B NOTCH1	2.52e-05	285	26	5	GO:0007411
GeneOntologyBiologicalProcess	neuron projection guidance	LRP1 LRP2 LAMB2 SEMA5B NOTCH1	2.56e-05	286	26	5	GO:0097485
GeneOntologyBiologicalProcess	positive regulation of protein catabolic process in the vacuole	LRP1 LRP2	3.20e-05	7	26	2	GO:1904352
GeneOntologyBiologicalProcess	glial cell differentiation	LRP1 LAMB2 ITGB4 NOTCH1 CRB1	4.45e-05	321	26	5	GO:0010001
GeneOntologyBiologicalProcess	neuron projection morphogenesis	LRP1 LRP2 LAMB2 CELSR2 SEMA5B NOTCH1 PLXNB1	4.50e-05	802	26	7	GO:0048812
GeneOntologyBiologicalProcess	neuron development	LRP1 LRP2 LAMB2 UNK CELSR2 SEMA5B NOTCH1 PLXNB1 CRB1	4.58e-05	1463	26	9	GO:0048666
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	LRP1 LRP2 LAMB2 CELSR2 SEMA5B NOTCH1 PLXNB1	5.15e-05	819	26	7	GO:0120039
GeneOntologyBiologicalProcess	anatomical structure homeostasis	ADRB2 MUC2 USH2A NOTCH1 CRB1	5.37e-05	334	26	5	GO:0060249
GeneOntologyBiologicalProcess	tissue homeostasis	ADRB2 MUC2 USH2A NOTCH1 CRB1	5.37e-05	334	26	5	GO:0001894
GeneOntologyBiologicalProcess	cell projection morphogenesis	LRP1 LRP2 LAMB2 CELSR2 SEMA5B NOTCH1 PLXNB1	5.43e-05	826	26	7	GO:0048858
GeneOntologyBiologicalProcess	axonogenesis	LRP1 LRP2 LAMB2 SEMA5B NOTCH1 PLXNB1	5.99e-05	566	26	6	GO:0007409
GeneOntologyBiologicalProcess	coronary artery morphogenesis	LRP2 NOTCH1	6.83e-05	10	26	2	GO:0060982
GeneOntologyBiologicalProcess	kidney development	LRP2 LAMB2 FBN1 NOTCH1 APAF1	8.94e-05	372	26	5	GO:0001822
GeneOntologyBiologicalProcess	regulation of lysosomal protein catabolic process	LRP1 LRP2	1.00e-04	12	26	2	GO:1905165
GeneOntologyBiologicalProcess	renal system development	LRP2 LAMB2 FBN1 NOTCH1 APAF1	1.06e-04	386	26	5	GO:0072001
GeneOntologyBiologicalProcess	axon development	LRP1 LRP2 LAMB2 SEMA5B NOTCH1 PLXNB1	1.20e-04	642	26	6	GO:0061564
GeneOntologyBiologicalProcess	negative regulation of BMP signaling pathway	LRP2 FBN1 NOTCH1	1.37e-04	80	26	3	GO:0030514
GeneOntologyBiologicalProcess	aorta development	LRP1 LRP2 NOTCH1	1.37e-04	80	26	3	GO:0035904
GeneOntologyBiologicalProcess	regulation of protein catabolic process in the vacuole	LRP1 LRP2	1.38e-04	14	26	2	GO:1904350
GeneOntologyBiologicalProcess	cell-substrate adhesion	LRP1 LAMB2 COL26A1 ITGB4 NOTCH1	1.41e-04	410	26	5	GO:0031589
GeneOntologyBiologicalProcess	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	LRP1 LRP2 FBN1 NOTCH1	1.51e-04	218	26	4	GO:0090101
GeneOntologyBiologicalProcess	coronary vasculature development	LRP1 LRP2 NOTCH1	1.53e-04	83	26	3	GO:0060976
GeneOntologyBiologicalProcess	regulation of extracellular matrix organization	LRP1 LAMB2 NOTCH1	1.58e-04	84	26	3	GO:1903053
GeneOntologyBiologicalProcess	visual perception	LAMB2 SEMA5B USH2A CRB1	1.86e-04	230	26	4	GO:0007601
GeneOntologyBiologicalProcess	sensory perception of light stimulus	LAMB2 SEMA5B USH2A CRB1	1.95e-04	233	26	4	GO:0050953
GeneOntologyBiologicalProcess	artery morphogenesis	LRP1 LRP2 NOTCH1	2.07e-04	92	26	3	GO:0048844
GeneOntologyBiologicalProcess	astrocyte differentiation	LRP1 LAMB2 NOTCH1	3.06e-04	105	26	3	GO:0048708
GeneOntologyBiologicalProcess	lysosomal protein catabolic process	LRP1 LRP2	4.15e-04	24	26	2	GO:1905146
GeneOntologyBiologicalProcess	transcytosis	LRP1 LRP2	4.15e-04	24	26	2	GO:0045056
GeneOntologyBiologicalProcess	detection of light stimulus involved in visual perception	SEMA5B CRB1	4.50e-04	25	26	2	GO:0050908
GeneOntologyBiologicalProcess	detection of light stimulus involved in sensory perception	SEMA5B CRB1	4.50e-04	25	26	2	GO:0050962
GeneOntologyBiologicalProcess	developmental growth involved in morphogenesis	LRP1 LAMB2 SEMA5B NOTCH1	5.03e-04	299	26	4	GO:0060560
GeneOntologyBiologicalProcess	protein catabolic process in the vacuole	LRP1 LRP2	5.66e-04	28	26	2	GO:0007039
GeneOntologyBiologicalProcess	lipoprotein transport	LRP1 LRP2	5.66e-04	28	26	2	GO:0042953
GeneOntologyBiologicalProcess	regulation of BMP signaling pathway	LRP2 FBN1 NOTCH1	5.85e-04	131	26	3	GO:0030510
GeneOntologyBiologicalProcess	lipoprotein localization	LRP1 LRP2	6.07e-04	29	26	2	GO:0044872
GeneOntologyBiologicalProcess	artery development	LRP1 LRP2 NOTCH1	6.11e-04	133	26	3	GO:0060840
GeneOntologyBiologicalProcess	cardiac septum development	LRP1 LRP2 NOTCH1	6.25e-04	134	26	3	GO:0003279
GeneOntologyBiologicalProcess	axon extension	LRP1 LAMB2 SEMA5B	6.39e-04	135	26	3	GO:0048675
GeneOntologyBiologicalProcess	neuron projection development	LRP1 LRP2 LAMB2 CELSR2 SEMA5B NOTCH1 PLXNB1	8.25e-04	1285	26	7	GO:0031175
GeneOntologyBiologicalProcess	coronary vasculature morphogenesis	LRP2 NOTCH1	8.36e-04	34	26	2	GO:0060977
GeneOntologyBiologicalProcess	regulation of cell adhesion	LRP1 LAMB2 CELSR2 COL26A1 NOTCH1 PLXNB1	8.61e-04	927	26	6	GO:0030155
GeneOntologyBiologicalProcess	negative regulation of cellular response to growth factor stimulus	LRP2 FBN1 NOTCH1	8.67e-04	150	26	3	GO:0090288
GeneOntologyBiologicalProcess	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	LRP1 LRP2 FBN1 NOTCH1	8.78e-04	347	26	4	GO:0090092
GeneOntologyBiologicalProcess	heart formation	LRP2 NOTCH1	9.38e-04	36	26	2	GO:0060914
GeneOntologyBiologicalProcess	positive regulation of neurogenesis	LRP1 LRP2 NOTCH1 PLXNB1	9.46e-04	354	26	4	GO:0050769
GeneOntologyBiologicalProcess	glial cell development	LRP1 LAMB2 ITGB4	9.89e-04	157	26	3	GO:0021782
GeneOntologyBiologicalProcess	female sex differentiation	LRP2 NR5A1 NOTCH1	9.89e-04	157	26	3	GO:0046660
GeneOntologyBiologicalProcess	amyloid-beta clearance	LRP1 LRP2	1.16e-03	40	26	2	GO:0097242
GeneOntologyBiologicalProcess	response to abiotic stimulus	LRP2 ADRB2 PKD1L3 SEMA5B NOTCH1 CRB1 APAF1	1.16e-03	1361	26	7	GO:0009628
GeneOntologyBiologicalProcess	aorta morphogenesis	LRP1 NOTCH1	1.22e-03	41	26	2	GO:0035909
GeneOntologyBiologicalProcess	detection of external stimulus	PKD1L3 SEMA5B CRB1	1.31e-03	173	26	3	GO:0009581
GeneOntologyBiologicalProcess	detection of abiotic stimulus	PKD1L3 SEMA5B CRB1	1.35e-03	175	26	3	GO:0009582
GeneOntologyBiologicalProcess	photoreceptor cell maintenance	USH2A CRB1	1.60e-03	47	26	2	GO:0045494
GeneOntologyBiologicalProcess	astrocyte development	LRP1 LAMB2	1.60e-03	47	26	2	GO:0014002
GeneOntologyBiologicalProcess	Schwann cell development	LAMB2 ITGB4	1.60e-03	47	26	2	GO:0014044
GeneOntologyBiologicalProcess	epithelial cell differentiation involved in kidney development	LAMB2 NOTCH1	1.60e-03	47	26	2	GO:0035850
GeneOntologyBiologicalProcess	tube formation	LRP2 NOTCH1 APAF1	1.64e-03	187	26	3	GO:0035148
GeneOntologyBiologicalProcess	regulation of cellular response to growth factor stimulus	LRP1 LRP2 FBN1 NOTCH1	1.66e-03	412	26	4	GO:0090287
GeneOntologyBiologicalProcess	protein kinase A signaling	FBN1 ADRB2	1.66e-03	48	26	2	GO:0010737
GeneOntologyBiologicalProcess	cellular response to amyloid-beta	LRP1 ADRB2	1.73e-03	49	26	2	GO:1904646
GeneOntologyBiologicalProcess	positive regulation of nervous system development	LRP1 LRP2 NOTCH1 PLXNB1	1.75e-03	418	26	4	GO:0051962
GeneOntologyBiologicalProcess	negative regulation of ossification	ADRB2 NOTCH1	1.80e-03	50	26	2	GO:0030279
GeneOntologyBiologicalProcess	epithelium development	LRP2 LAMB2 NR5A1 MUC2 USH2A NOTCH1 APAF1	1.81e-03	1469	26	7	GO:0060429
GeneOntologyBiologicalProcess	sensory perception	LRP2 LAMB2 PKD1L3 SEMA5B USH2A CRB1	1.82e-03	1072	26	6	GO:0007600
GeneOntologyBiologicalProcess	BMP signaling pathway	LRP2 FBN1 NOTCH1	1.90e-03	197	26	3	GO:0030509
GeneOntologyBiologicalProcess	semaphorin-plexin signaling pathway	SEMA5B PLXNB1	1.95e-03	52	26	2	GO:0071526
GeneOntologyBiologicalProcess	neural tube development	LRP2 NOTCH1 APAF1	2.04e-03	202	26	3	GO:0021915
GeneOntologyBiologicalProcess	Schwann cell differentiation	LAMB2 ITGB4	2.18e-03	55	26	2	GO:0014037
GeneOntologyBiologicalProcess	neuron projection extension	LRP1 LAMB2 SEMA5B	2.18e-03	207	26	3	GO:1990138
GeneOntologyBiologicalProcess	transforming growth factor beta receptor superfamily signaling pathway	LRP1 LRP2 FBN1 NOTCH1	2.19e-03	445	26	4	GO:0141091
GeneOntologyBiologicalProcess	regulation of neurotransmitter receptor activity	ADRB2 NOTCH1	2.26e-03	56	26	2	GO:0099601
GeneOntologyBiologicalProcess	retina development in camera-type eye	LAMB2 NOTCH1 CRB1	2.31e-03	211	26	3	GO:0060041
GeneOntologyBiologicalProcess	cell differentiation involved in kidney development	LAMB2 NOTCH1	2.34e-03	57	26	2	GO:0061005
GeneOntologyBiologicalProcess	detection of visible light	SEMA5B CRB1	2.34e-03	57	26	2	GO:0009584
GeneOntologyBiologicalProcess	cardiac chamber development	LRP1 LRP2 NOTCH1	2.34e-03	212	26	3	GO:0003205
GeneOntologyBiologicalProcess	response to BMP	LRP2 FBN1 NOTCH1	2.43e-03	215	26	3	GO:0071772
GeneOntologyBiologicalProcess	cellular response to BMP stimulus	LRP2 FBN1 NOTCH1	2.43e-03	215	26	3	GO:0071773
GeneOntologyBiologicalProcess	extracellular matrix assembly	LAMB2 NOTCH1	2.50e-03	59	26	2	GO:0085029
GeneOntologyBiologicalProcess	ventricular cardiac muscle tissue morphogenesis	LRP2 NOTCH1	2.50e-03	59	26	2	GO:0055010
GeneOntologyCellularComponent	receptor complex	LRP1 LRP2 EPS8 ADRB2 PKD1L3 ITGB4 NOTCH1 PLXNB1	4.72e-07	581	27	8	GO:0043235
GeneOntologyCellularComponent	basement membrane	LAMB2 FBN1 USH2A ITGB4	1.75e-05	122	27	4	GO:0005604
GeneOntologyCellularComponent	collagen-containing extracellular matrix	LAMB2 FBN1 COL26A1 MUC2 USH2A ITGB4	4.86e-05	530	27	6	GO:0062023
GeneOntologyCellularComponent	apical part of cell	LRP1 LRP2 ADRB2 USH2A NOTCH1 CRB1	8.96e-05	592	27	6	GO:0045177
GeneOntologyCellularComponent	extracellular matrix	LAMB2 FBN1 COL26A1 MUC2 USH2A ITGB4	1.57e-04	656	27	6	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	LAMB2 FBN1 COL26A1 MUC2 USH2A ITGB4	1.60e-04	658	27	6	GO:0030312
GeneOntologyCellularComponent	apical plasma membrane	LRP2 ADRB2 USH2A NOTCH1 CRB1	3.55e-04	487	27	5	GO:0016324
GeneOntologyCellularComponent	axonal growth cone	LRP1 LRP2	1.54e-03	45	27	2	GO:0044295
GeneOntologyCellularComponent	postsynaptic membrane	LRP1 ADRB2 ITGB4 NOTCH1	1.71e-03	405	27	4	GO:0045211
GeneOntologyCellularComponent	distal axon	LRP1 LRP2 EPS8 USH2A	2.22e-03	435	27	4	GO:0150034
GeneOntologyCellularComponent	endocytic vesicle membrane	LRP1 LRP2 ADRB2	2.51e-03	212	27	3	GO:0030666
GeneOntologyCellularComponent	protein complex involved in cell adhesion	LAMB2 ITGB4	2.63e-03	59	27	2	GO:0098636
GeneOntologyCellularComponent	cluster of actin-based cell projections	LRP2 EPS8 USH2A	2.90e-03	223	27	3	GO:0098862
GeneOntologyCellularComponent	clathrin-coated vesicle	LRP1 LRP2 ADRB2	3.44e-03	237	27	3	GO:0030136
GeneOntologyCellularComponent	glutamatergic synapse	LRP1 EPS8 ADRB2 ITGB4 NOTCH1	3.55e-03	817	27	5	GO:0098978
GeneOntologyCellularComponent	stereocilium	EPS8 USH2A	3.57e-03	69	27	2	GO:0032420
GeneOntologyCellularComponent	growth cone	LRP1 LRP2 EPS8	3.78e-03	245	27	3	GO:0030426
GeneOntologyCellularComponent	site of polarized growth	LRP1 LRP2 EPS8	4.13e-03	253	27	3	GO:0030427
GeneOntologyCellularComponent	photoreceptor inner segment	USH2A CRB1	4.54e-03	78	27	2	GO:0001917
GeneOntologyCellularComponent	clathrin-coated endocytic vesicle membrane	LRP2 ADRB2	4.66e-03	79	27	2	GO:0030669
GeneOntologyCellularComponent	stereocilium bundle	EPS8 USH2A	4.66e-03	79	27	2	GO:0032421
GeneOntologyCellularComponent	clathrin-coated pit	LRP1 LRP2	4.77e-03	80	27	2	GO:0005905
GeneOntologyCellularComponent	axon	LRP1 LRP2 EPS8 ADRB2 USH2A	5.14e-03	891	27	5	GO:0030424
GeneOntologyCellularComponent	actin-based cell projection	EPS8 USH2A CRB1	5.37e-03	278	27	3	GO:0098858
GeneOntologyCellularComponent	synaptic membrane	LRP1 ADRB2 ITGB4 NOTCH1	6.31e-03	583	27	4	GO:0097060
GeneOntologyCellularComponent	clathrin-coated endocytic vesicle	LRP2 ADRB2	7.50e-03	101	27	2	GO:0045334
GeneOntologyCellularComponent	endoplasmic reticulum lumen	LAMB2 FBN1 COL26A1	8.76e-03	332	27	3	GO:0005788
GeneOntologyCellularComponent	postsynapse	LRP1 EPS8 ADRB2 ITGB4 NOTCH1	8.95e-03	1018	27	5	GO:0098794
GeneOntologyCellularComponent	coated vesicle	LRP1 LRP2 ADRB2	1.09e-02	360	27	3	GO:0030135
GeneOntologyCellularComponent	cell surface	LRP1 LRP2 PKD1L3 ITGB4 NOTCH1	1.28e-02	1111	27	5	GO:0009986
GeneOntologyCellularComponent	endocytic vesicle	LRP1 LRP2 ADRB2	1.30e-02	384	27	3	GO:0030139
GeneOntologyCellularComponent	photoreceptor cell cilium	USH2A CRB1	1.38e-02	139	27	2	GO:0097733
GeneOntologyCellularComponent	clathrin-coated vesicle membrane	LRP2 ADRB2	1.54e-02	147	27	2	GO:0030665
GeneOntologyCellularComponent	brush border	LRP2 EPS8	1.64e-02	152	27	2	GO:0005903
GeneOntologyCellularComponent	9+0 non-motile cilium	USH2A CRB1	1.66e-02	153	27	2	GO:0097731
GeneOntologyCellularComponent	Schaffer collateral - CA1 synapse	ADRB2 NOTCH1	1.70e-02	155	27	2	GO:0098685
GeneOntologyCellularComponent	postsynaptic density membrane	LRP1 NOTCH1	1.74e-02	157	27	2	GO:0098839
GeneOntologyCellularComponent	plasma membrane protein complex	LRP1 EPS8 ITGB4 CRB1	1.74e-02	785	27	4	GO:0098797
GeneOntologyCellularComponent	cell projection membrane	LRP2 EPS8 USH2A	1.76e-02	431	27	3	GO:0031253
HumanPheno	Hypoplasia of the iris	LRP2 LAMB2 FBN1	3.45e-05	35	10	3	HP:0007676
MousePheno	abnormal Muller cell morphology	LAMB2 ADRB2 CRB1	3.28e-06	20	21	3	MP:0005547
MousePheno	short photoreceptor inner segment	LAMB2 USH2A CRB1	7.43e-06	26	21	3	MP:0008582
MousePheno	decreased sensory neuron number	LAMB2 ADRB2 USH2A CRB1	1.37e-04	181	21	4	MP:0000966
MousePheno	abnormal photoreceptor inner segment morphology	LAMB2 USH2A CRB1	1.38e-04	68	21	3	MP:0003730
MousePheno	short photoreceptor outer segment	LAMB2 USH2A CRB1	1.84e-04	75	21	3	MP:0008587
MousePheno	abnormal photoreceptor outer segment size	LAMB2 USH2A CRB1	2.07e-04	78	21	3	MP:0020811
MousePheno	small embryonic telencephalon	LRP2 APAF1	2.23e-04	15	21	2	MP:0000936
MousePheno	internal hemorrhage	LRP1 FBN1 NOTCH1 ADGRL4 APAF1	2.24e-04	387	21	5	MP:0001634
MousePheno	abnormal retina morphology	LAMB2 ADRB2 USH2A SHISAL1 NOTCH1 CRB1 ADGRL4 APAF1	2.48e-04	1227	21	8	MP:0001325
MousePheno	abnormal forehead shape	LRP2 APAF1	2.88e-04	17	21	2	MP:0030045
MousePheno	abnormal ocular fundus morphology	LAMB2 ADRB2 USH2A SHISAL1 NOTCH1 CRB1 ADGRL4 APAF1	3.01e-04	1262	21	8	MP:0002864
MousePheno	abnormal cochlear labyrinth morphology	LRP2 EPS8 USH2A NOTCH1	3.72e-04	235	21	4	MP:0004426
MousePheno	abnormal scala media morphology	LRP2 EPS8 USH2A NOTCH1	3.72e-04	235	21	4	MP:0003169
MousePheno	abnormal retina neuronal layer morphology	LAMB2 ADRB2 USH2A CRB1 APAF1	4.09e-04	441	21	5	MP:0006069
MousePheno	abnormal somatic sensory system morphology	LAMB2 EPS8 ADRB2 USH2A NOTCH1 CRB1	4.45e-04	702	21	6	MP:0000959
MousePheno	abnormal cochlea morphology	LRP2 EPS8 USH2A NOTCH1	4.56e-04	248	21	4	MP:0000031
MousePheno	abnormal neuron number	LAMB2 ADRB2 USH2A NOTCH1 CRB1	4.77e-04	456	21	5	MP:0008946
MousePheno	abnormal embryonic neuroepithelium morphology	LRP2 NOTCH1 APAF1	4.96e-04	105	21	3	MP:0004261
MousePheno	abnormal somatic nervous system morphology	LAMB2 UNK EPS8 ADRB2 USH2A NOTCH1 CRB1	5.20e-04	1025	21	7	MP:0002752
MousePheno	abnormal ear morphology	LRP2 EPS8 USH2A NOTCH1 APAF1	5.48e-04	470	21	5	MP:0002102
MousePheno	abnormal membranous labyrinth morphology	LRP2 EPS8 USH2A NOTCH1	5.61e-04	262	21	4	MP:0000035
MousePheno	abnormal sensory neuron morphology	LAMB2 ADRB2 USH2A NOTCH1 CRB1	5.64e-04	473	21	5	MP:0000965
MousePheno	abnormal forehead morphology	LRP2 APAF1	5.82e-04	24	21	2	MP:0030031
MousePheno	retina fold	CRB1 APAF1	6.32e-04	25	21	2	MP:0021107
MousePheno	abnormal retina layer morphology	LAMB2 ADRB2 USH2A CRB1 APAF1	7.52e-04	504	21	5	MP:0003727
MousePheno	diaphragmatic hernia	LRP1 FBN1	8.52e-04	29	21	2	MP:0003924
MousePheno	abnormal blood vessel morphology	LRP2 UNK FBN1 SHISAL1 ITGB4 NOTCH1 CRB1 ADGRL4	8.57e-04	1472	21	8	MP:0001614
MousePheno	abnormal heart valve physiology	FBN1 NOTCH1	9.12e-04	30	21	2	MP:0011926
MousePheno	abnormal inner ear morphology	LRP2 EPS8 USH2A NOTCH1	9.68e-04	303	21	4	MP:0000026
MousePheno	delayed neural tube closure	LRP2 APAF1	9.74e-04	31	21	2	MP:0002621
MousePheno	increased hemangioma incidence	UNK NOTCH1	1.04e-03	32	21	2	MP:0002947
MousePheno	abnormal photoreceptor outer segment morphology	LAMB2 USH2A CRB1	1.17e-03	141	21	3	MP:0003729
MousePheno	abnormal testis development	LRP2 NR5A1	1.17e-03	34	21	2	MP:0003830
MousePheno	overexpanded pulmonary alveolus	LRP2 FBN1	1.39e-03	37	21	2	MP:0001183
MousePheno	emphysema	LRP2 FBN1	1.39e-03	37	21	2	MP:0001958
MousePheno	hearing/vestibular/ear phenotype	LRP2 EPS8 ADRB2 USH2A NOTCH1 APAF1	1.69e-03	905	21	6	MP:0005377
MousePheno	abnormal eye physiology	LAMB2 ADRB2 USH2A CRB1 ADGRL4	1.72e-03	606	21	5	MP:0005253
MousePheno	heart right ventricle hypertrophy	LRP2 FBN1	1.78e-03	42	21	2	MP:0000276
MousePheno	abnormal lateral ventricle morphology	LRP2 CELSR2 APAF1	1.81e-03	164	21	3	MP:0000823
MousePheno	lethality during fetal growth through weaning, complete penetrance	LRP1 LRP2 LAMB2 NR5A1 FBN1 ITGB4 APAF1	1.86e-03	1269	21	7	MP:0011111
MousePheno	abnormal hypothalamus morphology	NR5A1 APAF1	1.96e-03	44	21	2	MP:0000837
MousePheno	decreased respiration	LRP2 FBN1 ITGB4	2.00e-03	170	21	3	MP:0014274
MousePheno	increased retina apoptosis	LAMB2 ADRB2	2.05e-03	45	21	2	MP:0030005
MousePheno	decreased neuron number	LAMB2 ADRB2 USH2A CRB1	2.14e-03	376	21	4	MP:0008948
MousePheno	abnormal nasal septum morphology	LRP2 APAF1	2.23e-03	47	21	2	MP:0002239
MousePheno	abnormal choroid plexus morphology	LRP2 APAF1	2.33e-03	48	21	2	MP:0000820
MousePheno	abnormal tela choroidea morphology	LRP2 APAF1	2.33e-03	48	21	2	MP:0013306
MousePheno	abnormal cochlear outer hair cell number	USH2A NOTCH1	2.52e-03	50	21	2	MP:0004400
MousePheno	hemorrhage	LRP1 FBN1 NOTCH1 ADGRL4 APAF1	2.57e-03	664	21	5	MP:0001914
MousePheno	abnormal heart right ventricle wall morphology	LRP2 FBN1	2.72e-03	52	21	2	MP:0031534
MousePheno	omphalocele	LRP1 LRP2	2.83e-03	53	21	2	MP:0003052
MousePheno	increased heart right ventricle size	LRP2 FBN1	3.04e-03	55	21	2	MP:0010563
MousePheno	abnormal lung volume	FBN1 GPANK1	3.04e-03	55	21	2	MP:0001942
MousePheno	abnormal nose morphology	LRP2 ITGB4 APAF1	3.22e-03	201	21	3	MP:0002233
MousePheno	abnormal cochlear hair cell morphology	EPS8 USH2A NOTCH1	3.26e-03	202	21	3	MP:0002622
MousePheno	abnormal retina photoreceptor morphology	LAMB2 USH2A CRB1	3.45e-03	206	21	3	MP:0001004
MousePheno	perinatal lethality, complete penetrance	LRP1 LRP2 NR5A1 ITGB4 APAF1	3.48e-03	712	21	5	MP:0011089
MousePheno	abnormal cochlear sensory epithelium morphology	EPS8 USH2A NOTCH1	3.50e-03	207	21	3	MP:0003308
Domain	EGF_1	LRP1 LRP2 LAMB2 FBN1 CELSR2 USH2A ITGB4 NOTCH1 CRB1	2.42e-11	255	25	9	PS00022
Domain	EGF-like_CS	LRP1 LRP2 LAMB2 FBN1 CELSR2 ITGB4 NOTCH1 CRB1 ADGRL4	2.98e-11	261	25	9	IPR013032
Domain	EGF_2	LRP1 LRP2 LAMB2 FBN1 CELSR2 ITGB4 NOTCH1 CRB1 ADGRL4	3.41e-11	265	25	9	PS01186
Domain	ASX_HYDROXYL	LRP1 LRP2 FBN1 CELSR2 NOTCH1 CRB1 ADGRL4	4.53e-11	100	25	7	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	LRP1 LRP2 FBN1 CELSR2 NOTCH1 CRB1 ADGRL4	6.86e-11	106	25	7	IPR000152
Domain	EGF_CA	LRP1 LRP2 FBN1 CELSR2 NOTCH1 CRB1 ADGRL4	1.86e-10	122	25	7	SM00179
Domain	EGF-like_Ca-bd_dom	LRP1 LRP2 FBN1 CELSR2 NOTCH1 CRB1 ADGRL4	2.09e-10	124	25	7	IPR001881
Domain	EGF	LRP1 LRP2 LAMB2 FBN1 CELSR2 NOTCH1 CRB1 ADGRL4	5.02e-10	235	25	8	SM00181
Domain	EGF-like_dom	LRP1 LRP2 LAMB2 FBN1 CELSR2 NOTCH1 CRB1 ADGRL4	7.93e-10	249	25	8	IPR000742
Domain	Growth_fac_rcpt_	LRP1 LRP2 LAMB2 FBN1 CELSR2 NOTCH1 CRB1	1.05e-09	156	25	7	IPR009030
Domain	EGF_Ca-bd_CS	LRP1 LRP2 FBN1 NOTCH1 CRB1 ADGRL4	2.74e-09	97	25	6	IPR018097
Domain	EGF_CA	LRP1 LRP2 FBN1 NOTCH1 CRB1 ADGRL4	3.11e-09	99	25	6	PS01187
Domain	EGF_3	LRP1 LRP2 FBN1 CELSR2 NOTCH1 CRB1 ADGRL4	1.81e-08	235	25	7	PS50026
Domain	EGF_CA	LRP1 LRP2 FBN1 NOTCH1 ADGRL4	9.09e-08	86	25	5	PF07645
Domain	EGF	LRP1 LRP2 CELSR2 NOTCH1 CRB1	6.15e-07	126	25	5	PF00008
Domain	cEGF	LRP1 LRP2 FBN1	5.40e-06	26	25	3	IPR026823
Domain	cEGF	LRP1 LRP2 FBN1	5.40e-06	26	25	3	PF12662
Domain	hEGF	CELSR2 NOTCH1 CRB1	6.79e-06	28	25	3	PF12661
Domain	EGF_LAM_2	LAMB2 CELSR2 USH2A	8.40e-06	30	25	3	PS50027
Domain	EGF_LAM_1	LAMB2 CELSR2 USH2A	8.40e-06	30	25	3	PS01248
Domain	GPS	CELSR2 PKD1L3 ADGRL4	1.23e-05	34	25	3	SM00303
Domain	Laminin_EGF	LAMB2 CELSR2 USH2A	1.35e-05	35	25	3	PF00053
Domain	GPS	CELSR2 PKD1L3 ADGRL4	1.35e-05	35	25	3	PF01825
Domain	EGF_Lam	LAMB2 CELSR2 USH2A	1.35e-05	35	25	3	SM00180
Domain	GPS	CELSR2 PKD1L3 ADGRL4	1.47e-05	36	25	3	PS50221
Domain	GPS	CELSR2 PKD1L3 ADGRL4	1.60e-05	37	25	3	IPR000203
Domain	LAM_G_DOMAIN	CELSR2 USH2A CRB1	1.73e-05	38	25	3	PS50025
Domain	Laminin_EGF	LAMB2 CELSR2 USH2A	1.73e-05	38	25	3	IPR002049
Domain	Laminin_G_2	CELSR2 USH2A CRB1	2.03e-05	40	25	3	PF02210
Domain	PSI	SEMA5B ITGB4 PLXNB1	2.71e-05	44	25	3	IPR016201
Domain	LamG	CELSR2 USH2A CRB1	2.71e-05	44	25	3	SM00282
Domain	PSI	SEMA5B ITGB4 PLXNB1	3.10e-05	46	25	3	SM00423
Domain	Laminin_G	CELSR2 USH2A CRB1	6.23e-05	58	25	3	IPR001791
Domain	EGF_extracell	LRP2 ITGB4 NOTCH1	6.89e-05	60	25	3	IPR013111
Domain	EGF_2	LRP2 ITGB4 NOTCH1	6.89e-05	60	25	3	PF07974
Domain	GAIN_dom_N	CELSR2 ADGRL4	9.39e-05	11	25	2	IPR032471
Domain	GAIN	CELSR2 ADGRL4	9.39e-05	11	25	2	PF16489
Domain	Ldl_recept_b	LRP1 LRP2	1.55e-04	14	25	2	PF00058
Domain	LDLRB	LRP1 LRP2	1.55e-04	14	25	2	PS51120
Domain	TIL_dom	LRP2 MUC2	1.55e-04	14	25	2	IPR002919
Domain	LY	LRP1 LRP2	1.79e-04	15	25	2	SM00135
Domain	LDLR_classB_rpt	LRP1 LRP2	1.79e-04	15	25	2	IPR000033
Domain	ConA-like_dom	CELSR2 USH2A ITGB4 CRB1	1.92e-04	219	25	4	IPR013320
Domain	LAMININ_NTER	LAMB2 USH2A	2.04e-04	16	25	2	PS51117
Domain	Laminin_N	LAMB2 USH2A	2.04e-04	16	25	2	PF00055
Domain	Laminin_N	LAMB2 USH2A	2.04e-04	16	25	2	IPR008211
Domain	LamNT	LAMB2 USH2A	2.04e-04	16	25	2	SM00136
Domain	-	CELSR2 USH2A CRB1	2.70e-04	95	25	3	2.60.120.200
Domain	SEMA	SEMA5B PLXNB1	7.81e-04	31	25	2	PS51004
Domain	Sema	SEMA5B PLXNB1	7.81e-04	31	25	2	SM00630
Domain	Semap_dom	SEMA5B PLXNB1	7.81e-04	31	25	2	IPR001627
Domain	Sema	SEMA5B PLXNB1	7.81e-04	31	25	2	PF01403
Domain	Plexin_repeat	SEMA5B PLXNB1	8.32e-04	32	25	2	IPR002165
Domain	PSI	SEMA5B PLXNB1	8.32e-04	32	25	2	PF01437
Domain	-	LRP1 LRP2	1.24e-03	39	25	2	2.120.10.30
Domain	LDLR_class-A_CS	LRP1 LRP2	1.30e-03	40	25	2	IPR023415
Domain	Ldl_recept_a	LRP1 LRP2	1.64e-03	45	25	2	PF00057
Domain	-	LRP1 LRP2	1.72e-03	46	25	2	4.10.400.10
Domain	6-blade_b-propeller_TolB-like	LRP1 LRP2	1.72e-03	46	25	2	IPR011042
Domain	LDLRA_1	LRP1 LRP2	1.87e-03	48	25	2	PS01209
Domain	LDrepeatLR_classA_rpt	LRP1 LRP2	1.95e-03	49	25	2	IPR002172
Domain	LDLa	LRP1 LRP2	1.95e-03	49	25	2	SM00192
Domain	LDLRA_2	LRP1 LRP2	1.95e-03	49	25	2	PS50068
Domain	G_PROTEIN_RECEP_F2_2	CELSR2 ADGRL4	2.03e-03	50	25	2	PS00650
Domain	7tm_2	CELSR2 ADGRL4	2.03e-03	50	25	2	PF00002
Domain	GPCR_2-like	CELSR2 ADGRL4	2.90e-03	60	25	2	IPR017981
Domain	GPCR_2_secretin-like	CELSR2 ADGRL4	2.90e-03	60	25	2	IPR000832
Domain	G_PROTEIN_RECEP_F2_4	CELSR2 ADGRL4	3.00e-03	61	25	2	PS50261
Pathway	PID_INTEGRIN4_PATHWAY	LAMB2 ITGB4	9.40e-05	11	19	2	M158
Pathway	WP_PRIMARY_FOCAL_SEGMENTAL_GLOMERULOSCLEROSIS_FSGS	LAMB2 ITGB4 NOTCH1	1.17e-04	72	19	3	M39403
Pathway	WP_PRIMARY_FOCAL_SEGMENTAL_GLOMERULOSCLEROSIS_FSGS	LAMB2 ITGB4 NOTCH1	1.22e-04	73	19	3	MM15906
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	LRP1 LRP2 UNK FBN1 CRB1	2.39e-09	71	27	5	33541421
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	LRP1 LRP2 ADRB2 ITGB4 NOTCH1	1.43e-08	101	27	5	23382219
Pubmed	Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.	LRP1 LRP2	5.80e-07	2	27	2	34445520
Pubmed	Exome sequencing identified new mutations in a Marfan syndrome family.	LRP1 FBN1	5.80e-07	2	27	2	24484584
Pubmed	Application of a high-throughput genotyping method for loci exclusion in non-consanguineous Australian pedigrees with autosomal recessive retinitis pigmentosa.	USH2A CRB1	5.80e-07	2	27	2	22876132
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	LRP1 LAMB2 FBN1 NOTCH1	2.08e-06	118	27	4	21078624
Pubmed	Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis.	LRP1 LRP2	3.48e-06	4	27	2	12413896
Pubmed	Utility of molecular testing for related retinal dystrophies.	USH2A CRB1	3.48e-06	4	27	2	16767206
Pubmed	Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1.	LRP1 LRP2	3.48e-06	4	27	2	7775583
Pubmed	Role of apolipoprotein E receptors in regulating the differential in vivo neurotrophic effects of apolipoprotein E.	LRP1 LRP2	3.48e-06	4	27	2	11421580
Pubmed	ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its Rafts' association.	LRP1 LRP2	5.80e-06	5	27	2	16101684
Pubmed	Apoptosome inactivation rescues proneural and neural cells from neurodegeneration.	NOTCH1 APAF1	5.80e-06	5	27	2	15257302
Pubmed	Multiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesis.	LAMB2 ITGB4	5.80e-06	5	27	2	16581764
Pubmed	Nrf2 Transcriptional Activity Governs Intestine Development.	MUC2 NOTCH1	5.80e-06	5	27	2	35682851
Pubmed	Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.	LRP1 LRP2	5.80e-06	5	27	2	19047013
Pubmed	Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509.	LRP1 LRP2	5.80e-06	5	27	2	18685438
Pubmed	Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein.	LRP1 LRP2	8.69e-06	6	27	2	9837937
Pubmed	Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins.	LAMB2 ITGB4	8.69e-06	6	27	2	10671376
Pubmed	Notch1 haploinsufficiency causes ascending aortic aneurysms in mice.	FBN1 NOTCH1	1.22e-05	7	27	2	29093270
Pubmed	The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.	LRP1 LRP2	1.22e-05	7	27	2	12169628
Pubmed	Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.	LAMB2 SEMA5B NOTCH1 APAF1	2.03e-05	210	27	4	16537572
Pubmed	LDL receptor-related protein as a component of the midkine receptor.	LRP1 LRP2	2.08e-05	9	27	2	10772929
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	LRP1 LAMB2 FBN1 CELSR2 ITGB4 NOTCH1 PLXNB1	2.79e-05	1201	27	7	35696571
Pubmed	Impact of genomic polymorphism on arterial hypertension after aortic coarctation repair.	FBN1 ADRB2	3.18e-05	11	27	2	20537417
Pubmed	Paneth Cell Multipotency Induced by Notch Activation following Injury.	MUC2 NOTCH1	3.18e-05	11	27	2	29887318
Pubmed	LRP2 mediates folate uptake in the developing neural tube.	LRP1 LRP2	3.18e-05	11	27	2	24639464
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	LRP1 ITGB4 PLXNB1 ADGRL4	4.47e-05	257	27	4	16335952
Pubmed	Mechanochemical control of epidermal stem cell divisions by B-plexins.	NOTCH1 PLXNB1	4.50e-05	13	27	2	33637728
Pubmed	Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain.	LAMB2 ITGB4	4.50e-05	13	27	2	9670011
Pubmed	The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation.	NOTCH1 PLXNB1	5.25e-05	14	27	2	22955271
Pubmed	Stage-specific association of apolipoprotein A-I and E in developing mouse retina.	LRP1 LRP2	5.25e-05	14	27	2	17389516
Pubmed	Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.	LRP1 LRP2	5.25e-05	14	27	2	15082773
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	USP43 EPS8 CELSR2 NOTCH1 PLXNB1	6.90e-05	569	27	5	30639242
Pubmed	Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells.	ITGB4 NOTCH1	6.92e-05	16	27	2	19185577
Pubmed	Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression.	ITGB4 NOTCH1	6.92e-05	16	27	2	17021047
Pubmed	Hemidesmosome integrity protects the colon against colitis and colorectal cancer.	MUC2 ITGB4	8.81e-05	18	27	2	27371534
Pubmed	Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.	LRP1 LRP2	8.81e-05	18	27	2	10827173
Pubmed	Development of a diagnostic genetic test for simplex and autosomal recessive retinitis pigmentosa.	USH2A CRB1	8.81e-05	18	27	2	20591486
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	LRP2 UNK COL26A1 ITGB4 NOTCH1	9.43e-05	608	27	5	16713569
Pubmed	Generation of Distal Renal Segments Involves a Unique Population of Aqp2 + Progenitor Cells.	LRP2 NOTCH1	9.84e-05	19	27	2	34667084
Pubmed	Canonical notch signaling functions as a commitment switch in the epidermal lineage.	ITGB4 NOTCH1	1.21e-04	21	27	2	17079689
Pubmed	MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.	LRP1 LRP2	1.21e-04	21	27	2	21337463
Pubmed	The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation.	NR5A1 NOTCH1	1.45e-04	23	27	2	25505333
Pubmed	Aberrant epidermal differentiation and disrupted ΔNp63/Notch regulatory axis in Ets1 transgenic mice.	ITGB4 NOTCH1	1.45e-04	23	27	2	24337118
Pubmed	Primary cilia in murine palatal rugae development.	CELSR2 NOTCH1	1.45e-04	23	27	2	31226309
Pubmed	Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning.	ITGB4 NOTCH1	1.86e-04	26	27	2	25446530
Pubmed	Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.	SEMA5B PLXNB1	2.17e-04	28	27	2	18617019
Pubmed	Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.	LAMB2 FBN1 MUC2	2.26e-04	153	27	3	25037231
Pubmed	Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk.	LRP1 CELSR2	2.33e-04	29	27	2	20167577
Pubmed	Heritable Thoracic Aortic Disease Overview	FBN1 NOTCH1	2.49e-04	30	27	2	20301299
Pubmed	Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2.	NOTCH1 CRB1	2.49e-04	30	27	2	26496195
Pubmed	Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening.	LRP1 NOTCH1	2.66e-04	31	27	2	32546759
Pubmed	ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation.	ITGB4 NOTCH1	2.66e-04	31	27	2	22274697
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	LAMB2 FBN1 MUC2	2.92e-04	167	27	3	22159717
Pubmed	International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.	CELSR2 ADGRL4	3.02e-04	33	27	2	25713288
Pubmed	WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis.	LRP2 CELSR2	3.40e-04	35	27	2	30940800
Pubmed	Notch signaling in postnatal pituitary expansion: proliferation, progenitors, and cell specification.	NR5A1 NOTCH1	3.80e-04	37	27	2	24673559
Pubmed	MicroRNA-7a2 is Required for the Development of Pituitary Stem Cells.	NR5A1 NOTCH1	3.80e-04	37	27	2	35652338
Pubmed	Isolation and Characterization of Fetal Leydig Progenitor Cells of Male Mice.	NR5A1 NOTCH1	3.80e-04	37	27	2	26697723
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	LRP1 FBN1 NOTCH1	3.88e-04	184	27	3	32908313
Pubmed	HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2.	LRP2 NOTCH1	4.45e-04	40	27	2	23362348
Pubmed	Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.	MUC2 NOTCH1	4.67e-04	41	27	2	22675208
Pubmed	Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve.	NR5A1 NOTCH1	5.38e-04	44	27	2	37494420
Pubmed	DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1.	NOTCH1 APAF1	5.88e-04	46	27	2	11423996
Pubmed	Congenital Diaphragmatic Hernia Overview	LRP2 FBN1	5.88e-04	46	27	2	20301533
Pubmed	TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6.	SEMA5B PLXNB1	6.14e-04	47	27	2	35462405
Pubmed	Erk and MAPK signaling is essential for intestinal development through Wnt pathway modulation.	MUC2 NOTCH1	6.14e-04	47	27	2	32747435
Pubmed	Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.	LRP1 LRP2	6.14e-04	47	27	2	11208732
Pubmed	Analyses of shared genetic factors between asthma and obesity in children.	ADRB2 CRB1	6.14e-04	47	27	2	20816195
Pubmed	Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.	LRP1 LAMB2 FBN1	6.44e-04	219	27	3	31353912
Pubmed	Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.	FBN1 COL26A1	6.95e-04	50	27	2	23658023
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	UNK SEMA5B SHISAL1 PLXNB1	7.03e-04	529	27	4	14621295
Pubmed	Establishment and Dysfunction of the Blood-Brain Barrier.	LRP1 LRP2	7.51e-04	52	27	2	26590417
Pubmed	An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.	SEMA5B PLXNB1	7.51e-04	52	27	2	26633812
Pubmed	Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.	PLXNB1 APAF1	7.51e-04	52	27	2	9455477
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	LRP2 USH2A CRB1	7.71e-04	233	27	3	32290105
Interaction	ZDHHC15 interactions	LRP1 LRP2 UNK FBN1 CRB1	5.02e-07	125	26	5	int:ZDHHC15
Interaction	NTN5 interactions	LRP2 FBN1 NOTCH1	3.79e-06	24	26	3	int:NTN5
Interaction	SIRPD interactions	LAMB2 CELSR2 ITGB4 NOTCH1	4.30e-06	86	26	4	int:SIRPD
Interaction	ZFP41 interactions	LRP1 LRP2 FBN1	5.33e-05	57	26	3	int:ZFP41
Interaction	OBP2A interactions	LRP2 ADRB2	8.74e-05	11	26	2	int:OBP2A
Interaction	IGFL3 interactions	LRP2 LAMB2 NOTCH1	1.21e-04	75	26	3	int:IGFL3
Interaction	CUBN interactions	LRP1 LRP2	1.66e-04	15	26	2	int:CUBN
Interaction	SCN3A interactions	LRP1 LRP2	1.90e-04	16	26	2	int:SCN3A
GeneFamily	Low density lipoprotein receptors	LRP1 LRP2	1.09e-04	13	22	2	634
GeneFamily	Fibronectin type III domain containing	USH2A ITGB4	1.60e-02	160	22	2	555
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HRGL2A	LRP1 LRP2 LAMB2 SEMA5B NOTCH1 PLXNB1 CRB1	1.43e-06	600	26	7	M39055
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_500_k-means-cluster#5	LRP2 CELSR2 SHISAL1	3.88e-05	54	26	3	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_500_K5
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / Treatment groups by lineage, cell group, cell type	LAMB2 EPS8 FBN1 ITGB4 ADGRL4	1.23e-07	200	27	5	b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 COL26A1 SEMA5B SHISAL1	4.81e-06	188	27	4	053c251d3ddbeb866f34565aefca4535517b4387
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 COL26A1 SEMA5B SHISAL1	4.81e-06	188	27	4	7471c194276161422326647f09022e94f3d1640c
ToppCell	10x3'2.3-week_17-19-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	LAMB2 EPS8 FBN1 SEMA5B	4.91e-06	189	27	4	1ff4f8da572bdc6356e9df9f41a7f62c81d4c570
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LAMB2 ITGB4 NOTCH1 PLXNB1	5.01e-06	190	27	4	5c64b727669b23d2a23c8ad1d5d6caab7af37d56
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LAMB2 ITGB4 NOTCH1 PLXNB1	5.22e-06	192	27	4	f7e4509003d71f805b9d4587098e90d2897b6739
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LAMB2 ITGB4 NOTCH1 PLXNB1	5.22e-06	192	27	4	705ce805cb00a53793b57bcf466d0fbec590a83c
ToppCell	LA\|World / Chamber and Cluster_Paper	LRP1 LRP2 EPS8 FBN1	5.33e-06	193	27	4	d4bf89437216baf489ea0239136dcedf3b6714af
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LAMB2 ITGB4 NOTCH1 PLXNB1	5.33e-06	193	27	4	b03d908d4b8940927f72c76a1b0f237d13f39056
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LAMB2 ITGB4 NOTCH1 PLXNB1	5.33e-06	193	27	4	40edc07b6e7f19f6ee885fa5af0b63ef1b0f2468
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG-25\|World / Primary Cells by Cluster	LAMB2 ADRB2 SEMA5B NOTCH1	5.78e-06	197	27	4	9d4ffa3680f92c91d0a081f9a8ec5ebfec6bdcf6
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG\|World / Primary Cells by Cluster	LAMB2 ADRB2 SEMA5B NOTCH1	5.78e-06	197	27	4	61749ccafeb938c310cff1de5ff924a1c794325a
ToppCell	10x3'2.3-week_17-19-Mesenchymal_fibro-stroma-arteriolar_fibroblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	LRP1 LAMB2 EPS8 FBN1	6.02e-06	199	27	4	95d95e9b7bd3933188998ae94986213eb0f1e5ea
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Artery\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	LAMB2 FBN1 ITGB4 ADGRL4	6.14e-06	200	27	4	ac9ead34afa14067171833f5c277eaf06db7b02e
ToppCell	LPS-IL1RA-Endothelial-Epi-like-Alv_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LRP2 PKD1L3 GPANK1	7.82e-05	138	27	3	5f8ac8f67e34a7cf560099208e6884102532391e
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_bronchial_vessel\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SHISAL1 ITGB4 ADGRL4	9.25e-05	146	27	3	df865558d1843f3857ebd1529cebc540d3554c59
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 USH2A CRB1	1.21e-04	160	27	3	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 USH2A CRB1	1.21e-04	160	27	3	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma\|TCGA-Brain / Sample_Type by Project: Shred V9	ADRB2 ITGB4 PLXNB1	1.26e-04	162	27	3	810881210e015c788814e4fe8d7a24c929cf2621
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-Progenitor\|lymph-node_spleen / Manually curated celltypes from each tissue	FBN1 COL26A1 PLXNB1	1.33e-04	165	27	3	7b992843bd8ef92a7a76b1d681fa84efde6f5bdd
ToppCell	facs-Heart-RV-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 SHISAL1 CRB1	1.38e-04	167	27	3	3e3d8f6df2feefafad5b44ba0ebf5b5a0fe4ed58
ToppCell	facs-Heart-RV-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 SHISAL1 CRB1	1.38e-04	167	27	3	3ad9f3122dbe96580f640388ef920ea209fc2349
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L5-6_RORB_LINC00320\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MUC2 USH2A ADGRL4	1.38e-04	167	27	3	b0b2601c41c053b1caa6701ba2f5723e6059fb0a
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_vein-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHISAL1 ITGB4 ADGRL4	1.38e-04	167	27	3	d7fe24cdc4b55a9555ce9e20699f5036b88148e9
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LAMB2 ITGB4 NOTCH1	1.50e-04	172	27	3	55fba5ce0ead1114e1a76f67ad68432c6bac90e5
ToppCell	facs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NOTCH1 CRB1 ADGRL4	1.50e-04	172	27	3	c84cab89c97d647b8a256fd08e33d9102810febd
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LRP1 LAMB2 FBN1	1.55e-04	174	27	3	1d157f7a919c8246e83d8060d2a0017c6c781ef3
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PHTF2 FBN1 SEMA5B	1.58e-04	175	27	3	1b4cefae400bf756d09ece32d3f5c0bd4c6ad73f
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRP1 PHTF2 SEMA5B	1.58e-04	175	27	3	12f5fd83c7710fc0c77406f765d9cbd133433b8b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LRP1 EPS8 FBN1	1.61e-04	176	27	3	9bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LRP1 EPS8 FBN1	1.61e-04	176	27	3	3f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBN1 COL26A1 APAF1	1.63e-04	177	27	3	30f82b04e48940bfcaf2c22677efe6d57ae3f1a7
ToppCell	E12.5-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FBN1 SEMA5B NOTCH1	1.63e-04	177	27	3	5cdf413f82376a95467322b16d10b0d1e7557e2d
ToppCell	facs-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADRB2 ITGB4 ADGRL4	1.66e-04	178	27	3	ccd37575b60102f5e647c01546e8ff8fec638bd7
ToppCell	facs-Lung-18m-Endothelial-venous_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADRB2 ITGB4 ADGRL4	1.66e-04	178	27	3	87b04753650e45f12299c8456fb980d6c0d5961c
ToppCell	facs-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADRB2 ITGB4 ADGRL4	1.66e-04	178	27	3	ebfae386a518ea33911ba3ff40464c94d18ef695
ToppCell	COVID-19-kidney-AQP1+SLC14A1+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FBN1 ITGB4 ADGRL4	1.69e-04	179	27	3	1ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCell	droplet-Limb_Muscle-Pre-Sort\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 LAMB2 ITGB4	1.72e-04	180	27	3	af2bafcd1b2082629de3ea336711add01565c4c4
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR2 ITGB4 PLXNB1	1.72e-04	180	27	3	da723df348d7b8449bb1124f23fe6fa706412adb
ToppCell	droplet-Heart-nan-3m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR2 ITGB4 PLXNB1	1.72e-04	180	27	3	5b146a94708b3c3610542a4d0925f3f7a2b19185
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR2 ITGB4 PLXNB1	1.72e-04	180	27	3	50758b1e7be2e43f83c10ab106900c067e61f5f7
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 LAMB2 ITGB4	1.72e-04	180	27	3	f29a995cf6e1a1836ed68b73258d9370bf3d4434
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRP1 PHTF2 SEMA5B	1.74e-04	181	27	3	a2058d658f07ab6f0a28d2622f3090b4cde6f763
ToppCell	PCW_10-12-Neuronal-Neuronal_postreplicative\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CELSR2 ITGB4 CRB1	1.74e-04	181	27	3	1aebb62ed4439db444ee9d30688212b86ee3d9ef
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRP1 PHTF2 SEMA5B	1.74e-04	181	27	3	526e858a848470b6d2d5248788004d9735ed3add
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB2 ADGRL4 APAF1	1.74e-04	181	27	3	4df7972f88117108698efd06b124b232f8588981
ToppCell	PCW_10-12-Neuronal-Neuronal_postreplicative-neuro_NA\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CELSR2 ITGB4 CRB1	1.74e-04	181	27	3	6aee2ddee4790250ef3b2ef0038bd9839925c995
ToppCell	PCW_10-12-Neuronal\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CELSR2 ITGB4 CRB1	1.74e-04	181	27	3	381b553e2cae65ce6be100662a5f9f963353840c
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB2 ADGRL4 APAF1	1.74e-04	181	27	3	cbb530566893281289026bfd93adf721decd4ca3
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMB2 FBN1 ITGB4	1.77e-04	182	27	3	c7f2d24697affa530b748ab32b1d40bdc1bdc20a
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMB2 FBN1 ITGB4	1.77e-04	182	27	3	d95635b74e8cd8bc00bfe40340806b59fb9bee43
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 SEMA5B SHISAL1	1.83e-04	184	27	3	8d86e125257ff1d3af8d90577a8b3f0321eca21c
ToppCell	5'-GW_trimst-2-LymphNode-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FBN1 COL26A1 SEMA5B	1.83e-04	184	27	3	4d4d8f3f44c67d74c57e7af7b7c158f0157b2f49
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 SEMA5B SHISAL1	1.83e-04	184	27	3	278a7ed764c326450cb70e69ed2175980eaf5fe0
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB2 FBN1 ITGB4	1.86e-04	185	27	3	f98af3146ec2f44c30d31a662fb9c4fa3ca4f706
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPS8 COL26A1 SEMA5B	1.86e-04	185	27	3	35d39a1d04c871edcfb749653538dc5fd0054281
ToppCell	COVID-19-Heart-Fib_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LRP1 EPS8 FBN1	1.86e-04	185	27	3	8f95d8e591bf7379d13f5a0545b0cb49e2b1ab5d
ToppCell	E17.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	LRP1 FBN1 COL26A1	1.86e-04	185	27	3	c85bba1210f1d389add3e40be9b96abac40cf8c1
ToppCell	facs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 LAMB2 FBN1	1.89e-04	186	27	3	a7ab70b049742dfe7ee30557031bfac6412edf52
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPS8 COL26A1 SEMA5B	1.89e-04	186	27	3	0b2ce9b8a4382d583240647217ad5e2d3fa555c1
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR2 ITGB4 NOTCH1	1.89e-04	186	27	3	bd1185592aedebccd1007dbf2dd2f549fcdf9f42
ToppCell	droplet-Liver-Npc-18m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB2 UNK ADGRL4	1.89e-04	186	27	3	75258d88e23112fd1f0f7c71ef0366abb400d33e
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CELSR2 NOTCH1 CRB1	1.89e-04	186	27	3	76535681667c8afb884fa72b6edfee9e1e46335b
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMB2 ITGB4 ADGRL4	1.89e-04	186	27	3	9c7924875f70420720149287c500b4dfa8d24673
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LRP1 PHTF2 SEMA5B	1.92e-04	187	27	3	ac8e092b37e042975e2ee057d3f7c6821e58e8b5
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LRP1 PHTF2 SEMA5B	1.92e-04	187	27	3	d591a3c216997663ab77710fed0d230ffc37e41a
ToppCell	facs-Trachea-nan-24m-Mesenchymal\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 LAMB2 FBN1	1.92e-04	187	27	3	71385068e3fd0bfa7822ae176113a49460c8636b
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro-Astrocyte\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ITGB4 NOTCH1 PLXNB1	1.92e-04	187	27	3	5c73010fe4c85fb5cc1273f5504821229ca0cc4b
ToppCell	facs-Trachea-nan-24m-Mesenchymal-fibroblast\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 LAMB2 FBN1	1.92e-04	187	27	3	b930d5f7d410ac1f340babec5c937388f64cafc0
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ITGB4 NOTCH1 PLXNB1	1.92e-04	187	27	3	dd1d91f101b837bba513f77defa6e6902b2c0570
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_vein\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHISAL1 ITGB4 ADGRL4	1.92e-04	187	27	3	e35716f8b482be3bf5ab79f087a9caf67a9d197a
ToppCell	facs-Trachea-nan-24m-Mesenchymal-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 LAMB2 FBN1	1.92e-04	187	27	3	e891e571f6bb9433a0046215de6cabd89ed1effc
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ITGB4 NOTCH1 PLXNB1	1.92e-04	187	27	3	ae90c263f80c36a410150d499e268d198944a3d9
ToppCell	droplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 ITGB4 ADGRL4	1.92e-04	187	27	3	e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ITGB4 NOTCH1 PLXNB1	1.92e-04	187	27	3	5d3d68519c8e19f10c29f9d81712125be78ca15a
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LRP1 PHTF2 SEMA5B	1.92e-04	187	27	3	d1dc8c9a2c2cd10c640257161a75e7730ec5bb41
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPS8 COL26A1 SEMA5B	1.95e-04	188	27	3	0a5b93c131ce8514e996b0c2f39e0fc98636c122
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ITGB4 NOTCH1 ADGRL4	1.95e-04	188	27	3	366a2d59b9c81d8a7659749f9c07efa46b49a39a
ToppCell	facs-Lung\|facs / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADRB2 NOTCH1 ADGRL4	1.95e-04	188	27	3	f7292fc8e914f222828dcdb0a017d716207a97f6
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 SEMA5B SHISAL1	1.95e-04	188	27	3	a244fcd092d5bd544e503366b1439b0fbc1ee00e
ToppCell	droplet-Lung-nan-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB2 ITGB4 ADGRL4	1.95e-04	188	27	3	405efea75233ecf70f7d19b630230798d817b7f2
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 SEMA5B SHISAL1	1.95e-04	188	27	3	c8530c9ff98666c64a94683261af4288cb790a7e
ToppCell	facs-Lung\|facs / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADRB2 NOTCH1 ADGRL4	1.95e-04	188	27	3	e2b6e14579ec649a2bc106d9c99bb78ceb16ede3
ToppCell	COVID-19-Heart-Fib_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LRP1 EPS8 FBN1	1.95e-04	188	27	3	fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ITGB4 NOTCH1 ADGRL4	1.98e-04	189	27	3	db09d591b885ce2bc9e353f08b6694e2192582e1
ToppCell	facs-Kidney-nan-24m-Endothelial-fenestrated_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB2 NOTCH1 ADGRL4	1.98e-04	189	27	3	9d02a824bba59ea0660439f0510d843568e9d8c3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 ITGB4 ADGRL4	1.98e-04	189	27	3	12b6f1c3bf526b90e112374bf937701f645c5780
ToppCell	facs-Kidney-nan-24m-Endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB2 NOTCH1 ADGRL4	1.98e-04	189	27	3	5f8d4b61296c71b32362432a9ce4c1c3aaeb278d
ToppCell	facs-Kidney-nan-24m-Endothelial-Pecam____fenestrated_capillary_endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB2 NOTCH1 ADGRL4	1.98e-04	189	27	3	18f82764b32496e54d1a604a531b261651c5e110
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRP2 NOTCH1 PLXNB1	1.98e-04	189	27	3	42ab4cc5fbf8580841f31889446fe4499df1a464
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBN1 ITGB4 ADGRL4	1.98e-04	189	27	3	b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ITGB4 NOTCH1 ADGRL4	1.98e-04	189	27	3	55a1776a4ce049959b3f13a43744c7314bc1f00a
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR2 ITGB4 NOTCH1	1.98e-04	189	27	3	965e0e388251e7318f8b463816dc96ccb4658677
ToppCell	facs-Trachea-24m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_trachea\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CELSR2 ITGB4 PLXNB1	1.98e-04	189	27	3	ee15b4fb3a1cfda80bcf210a23f04f242594015e
ToppCell	facs-Trachea-24m-Epithelial-airway_epithelial-respiratory_basal_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CELSR2 ITGB4 PLXNB1	1.98e-04	189	27	3	dc6f6fae84347d145bea71b49eaeeb3028e9c4ae
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBN1 ITGB4 ADGRL4	1.98e-04	189	27	3	c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCell	facs-SCAT-Fat-24m-Mesenchymal-mesenchymal_progenitor\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 LAMB2 FBN1	2.01e-04	190	27	3	dc7e92f1b18d0f5efec11d09d56ba954d4f8b3bd
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRP2 NOTCH1 PLXNB1	2.01e-04	190	27	3	07f21386ea6eb23416a537d2250e3042efe93fb0
ToppCell	facs-SCAT-Fat-24m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 LAMB2 FBN1	2.01e-04	190	27	3	0bb06df3d5a50416854370f234718c6cec3d773b
ToppCell	droplet-Kidney-KIDNEY-30m-Endothelial-kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB2 ITGB4 ADGRL4	2.01e-04	190	27	3	5bf3d0beee69879c95265d07fba023626a7cc808
Computational	Genes in the cancer module 287.	FBN1 USH2A CRB1	7.36e-05	50	18	3	MODULE_287
Computational	DRG (dorsal root ganglia) genes.	LRP1 LAMB2 EPS8 FBN1 ITGB4	3.30e-04	384	18	5	MODULE_2
Computational	Metal / Ca ion binding.	LRP1 FBN1 CRB1	1.32e-03	133	18	3	MODULE_324
Drug	(R) -Naproxen sodium salt [26159-34-2]; Up 200; 15.8uM; HL60; HT_HG-U133A	PHTF2 LAMB2 CELSR2 CRB1 APAF1	2.55e-06	196	26	5	2533_UP
Drug	coprogen	LRP1 LRP2	4.49e-05	9	26	2	CID006323272
Drug	25-azacoprostane	LRP1 LRP2	5.61e-05	10	26	2	CID000162243
Drug	1-anilino-4-methyl-2-methylthio-4-phenylimidazolin-5-one	LRP2 LAMB2 FBN1 ADRB2 NOTCH1	5.69e-05	373	26	5	ctd:C540355
Drug	Nocodazole [31430-18-9]; Up 200; 13.2uM; PC3; HT_HG-U133A	LRP1 HINFP CELSR2 NOTCH1	6.08e-05	190	26	4	7145_UP
Drug	17-AAG; Down 200; 1uM; PC3; HT_HG-U133A	PHTF2 SHISAL1 ITGB4 APAF1	6.34e-05	192	26	4	4449_DN
Drug	Cotinine (-) [486-56-6]; Down 200; 22.6uM; PC3; HT_HG-U133A	LRP1 FBN1 SHISAL1 ITGB4	6.47e-05	193	26	4	4650_DN
Drug	Beta-Escin [11072-93-8]; Down 200; 3.2uM; PC3; HT_HG-U133A	LRP1 SHISAL1 ITGB4 PLXNB1	6.60e-05	194	26	4	3807_DN
Drug	Phenelzine sulfate [156-51-4]; Up 200; 17uM; PC3; HT_HG-U133A	LRP1 LRP2 ITGB4 APAF1	6.60e-05	194	26	4	4538_UP
Drug	S(-)Eticlopride hydrochloride [97612-24-3]; Up 200; 10.6uM; PC3; HT_HG-U133A	LRP1 SHISAL1 ITGB4 CRB1	6.73e-05	195	26	4	4634_UP
Drug	novobiocin sodium, USP; Down 200; 100uM; PC3; HG-U133A	LRP1 FBN1 CRB1 APAF1	7.00e-05	197	26	4	435_DN
Drug	Isoniazid [54-85-3]; Up 200; 29.2uM; PC3; HT_HG-U133A	LRP1 MUC2 SHISAL1 PLXNB1	7.14e-05	198	26	4	2083_UP
Drug	fludrocortisone	UNK NR5A1 ADRB2	8.79e-05	76	26	3	CID000031378
Disease	LDL cholesterol change measurement	CELSR2 PKD1L3	1.69e-05	7	27	2	EFO_0007804
Disease	cholangiocarcinoma (is_marker_for)	ADRB2 MUC2 NOTCH1	2.74e-05	64	27	3	DOID:4947 (is_marker_for)
Disease	Retinal Pigment Epithelial Detachment	CRB1 APAF1	2.89e-05	9	27	2	C0339546
Disease	ulcerative colitis (biomarker_via_orthology)	ADRB2 MUC2	2.89e-05	9	27	2	DOID:8577 (biomarker_via_orthology)
Disease	anorexia nervosa	LRP2 CRB1 ADGRL4	3.59e-05	70	27	3	MONDO_0005351
Disease	aortic aneurysm	LRP1 FBN1	3.61e-05	10	27	2	EFO_0001666
Disease	pneumonia (implicated_via_orthology)	ADRB2 MUC2	3.61e-05	10	27	2	DOID:552 (implicated_via_orthology)
Disease	Retinal Detachment	CRB1 APAF1	4.41e-05	11	27	2	C0035305
Disease	parental longevity	LAMB2 CELSR2 COL26A1 GPANK1 ADGRL4	7.67e-05	494	27	5	EFO_0007796
Disease	adult onset asthma	LRP1 MUC2 GPANK1	1.70e-04	118	27	3	EFO_1002011
Disease	retinitis pigmentosa (implicated_via_orthology)	USH2A CRB1	2.79e-04	27	27	2	DOID:10584 (implicated_via_orthology)
Disease	spontaneous coronary artery dissection	LRP1 FBN1	3.69e-04	31	27	2	EFO_0010820
Disease	Craniofacial Abnormalities	LRP2 NOTCH1 APAF1	3.86e-04	156	27	3	C0376634
Disease	liver cirrhosis (biomarker_via_orthology)	FBN1 MUC2	4.44e-04	34	27	2	DOID:5082 (biomarker_via_orthology)
Disease	asthma	LRP1 MUC2 GPANK1 CRB1 ADGRL4	5.34e-04	751	27	5	MONDO_0004979
Disease	colon cancer (biomarker_via_orthology)	MUC2 APAF1	5.85e-04	39	27	2	DOID:219 (biomarker_via_orthology)
Disease	retinitis pigmentosa (is_implicated_in)	USH2A CRB1	6.47e-04	41	27	2	DOID:10584 (is_implicated_in)
Disease	pain	LRP1 CELSR2 PKD1L3	7.51e-04	196	27	3	EFO_0003843

Protein segments in the cluster

Peptide	Gene	Start	Entry
LTYSNETHTSCRCNH	ADGRL4	391	Q9HBW9
DEHSEQVNCCHFTNS	APAF1	696	O14727
ATHQEAINCYANETC	ADRB2	176	P07550
VVFRNESHVSCQCNH	CELSR2	2341	Q9HCU4
TGHHCETNINECSSQ	NOTCH1	596	P46531
QYCENCDTHFQDSNH	GPANK1	216	O95872
HCTSQEHKCNASSQF	LRP1	2896	Q07954
QCHVTCQQHQLSYEA	PLXNB1	976	O43157
SLTHTYTHIESCQCQ	MUC2	5141	Q02817
TSCHQDEYSQQIVCH	LAMB2	941	P55268
DTQYTCDNHQCISKN	LRP2	1111	P98164
CHCHQQSLYTDTICE	ITGB4	601	P16144
HYCSQNQIEHCLCSN	OR56B2P	176	Q8NGI1
TQHHTSCIDNNECTS	FBN1	2516	P35555
NTIQHCQAVMHSCSY	EPS8	131	Q12929
HNNATCEDSVDNYTC	CRB1	311	P82279
QTSLDQQHFQCSHCS	HINFP	221	Q9BQA5
QYETISCNNCTDSHV	IZUMO4	136	Q1ZYL8
CHHTVTRTVSCQVQN	COL26A1	56	Q96A83
QCNSHSKSCHYNISV	USH2A	576	O75445
CHSSCTSETDVENHQ	PHTF2	416	Q8N3S3
VQNNKHYTCTESQSC	NR5A1	41	Q13285
QCSFEEAQHYCHVQR	PKD1L3	41	Q7Z443
HHNNTVFKYCCNETE	SHISAL1	61	Q3SXP7
HTQYCHQQTEVSFSE	REELD1	466	A0A1B0GV85
QQQAHQQHSCTLDEC	USP43	531	Q70EL4
YLSCQHCQRQSQEST	SEMA5B	1056	Q9P283
DACQYCHTRTEQQFH	UNK	276	Q9C0B0