Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	ZnF_C2HC	FAM90A14 FAM90A18 FAM90A9 FAM90A8 FAM90A10	2.54e-06	55	74	5	SM00343
Domain	Znf_CCHC	FAM90A14 FAM90A18 FAM90A9 FAM90A8 FAM90A10	2.54e-06	55	74	5	IPR001878
Domain	IRS_PTB	IRS4 TLN1 IRS2	2.11e-05	14	74	3	IPR002404
Domain	IRS	IRS4 TLN1 IRS2	2.11e-05	14	74	3	PF02174
Domain	PH	IRS4 TRIO RASGRF2 OBSCN IRS2 RASAL1	8.18e-04	278	74	6	SM00233
Domain	PTBI	IRS4 IRS2	8.32e-04	11	74	2	SM00310
Domain	PH_DOMAIN	IRS4 TRIO RASGRF2 OBSCN IRS2 RASAL1	8.33e-04	279	74	6	PS50003
Domain	PH_domain	IRS4 TRIO RASGRF2 OBSCN IRS2 RASAL1	8.49e-04	280	74	6	IPR001849
Domain	-	IRS4 TRIO RASGRF2 TLN1 OBSCN IRS2 RASAL1	9.01e-04	391	74	7	2.30.29.30
Domain	IRS_PTB	IRS4 IRS2	9.96e-04	12	74	2	PS51064
Domain	RasGAP	IQGAP3 RASAL1	1.37e-03	14	74	2	SM00323
Domain	RasGAP_CS	IQGAP3 RASAL1	1.37e-03	14	74	2	IPR023152
Domain	PH_dom-like	IRS4 TRIO RASGRF2 TLN1 OBSCN IRS2 RASAL1	1.48e-03	426	74	7	IPR011993
Domain	RasGAP	IQGAP3 RASAL1	1.57e-03	15	74	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	IQGAP3 RASAL1	1.57e-03	15	74	2	PS00509
Domain	RAS_GTPASE_ACTIV_2	IQGAP3 RASAL1	1.57e-03	15	74	2	PS50018
Domain	-	IQGAP3 RASAL1	1.79e-03	16	74	2	1.10.506.10
Domain	DH_1	TRIO RASGRF2 OBSCN	2.00e-03	63	74	3	PS00741
Domain	PH	TRIO RASGRF2 OBSCN IRS2 RASAL1	2.15e-03	229	74	5	PF00169
Domain	RasGAP_dom	IQGAP3 RASAL1	2.27e-03	18	74	2	IPR001936
Domain	RhoGEF	TRIO RASGRF2 OBSCN	2.49e-03	68	74	3	SM00325
Domain	RhoGEF	TRIO RASGRF2 OBSCN	2.70e-03	70	74	3	PF00621
Domain	DH_2	TRIO RASGRF2 OBSCN	2.70e-03	70	74	3	PS50010
Domain	DH-domain	TRIO RASGRF2 OBSCN	2.81e-03	71	74	3	IPR000219
Domain	-	TRIO RASGRF2 OBSCN	2.81e-03	71	74	3	1.20.900.10
Domain	Ser/Thr_kinase_AS	BMPR2 TRIO MAP3K8 OBSCN SRPK2 MAP3K6	2.91e-03	357	74	6	IPR008271
Domain	PROTEIN_KINASE_ST	BMPR2 TRIO MAP3K8 OBSCN SRPK2 MAP3K6	3.11e-03	362	74	6	PS00108
Domain	Pkinase	BMPR2 TRIO MAP3K8 OBSCN SRPK2 MAP3K6	4.00e-03	381	74	6	PF00069
Domain	IQ	RASGRF2 OBSCN IQGAP3	4.08e-03	81	74	3	SM00015
Domain	Integrin_dom	ITGA6 ITGB3	4.38e-03	25	74	2	IPR032695
Domain	IQ_motif_EF-hand-BS	RASGRF2 OBSCN IQGAP3	5.48e-03	90	74	3	IPR000048
Domain	Kinase-like_dom	BMPR2 TRIO MAP3K8 OBSCN SRPK2 TRRAP MAP3K6	5.61e-03	542	74	7	IPR011009
Domain	IQ	RASGRF2 OBSCN IQGAP3	6.00e-03	93	74	3	PS50096
Pathway	WP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY	IRS4 MAP3K8 CBLC IRS2 MAP3K6	9.14e-05	132	49	5	M39338
Pathway	REACTOME_RHOA_GTPASE_CYCLE	ARHGAP40 TRIO RASGRF2 OBSCN IQGAP3	1.29e-04	142	49	5	MM15576
Pathway	REACTOME_RHOA_GTPASE_CYCLE	ARHGAP40 TRIO RASGRF2 OBSCN IQGAP3	1.62e-04	149	49	5	M41805
Pathway	REACTOME_CDC42_GTPASE_CYCLE	ARHGAP40 TRIO RASGRF2 PARD6A IQGAP3	1.94e-04	155	49	5	M41808
Pathway	WP_INSULIN_SIGNALING	IRS4 MAP3K8 CBLC IRS2 MAP3K6	2.25e-04	160	49	5	M39482
Pathway	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	IRS4 PARD6A IRS2	7.31e-04	51	49	3	M7955
Pathway	REACTOME_RHO_GTPASE_CYCLE	ZNF512B ARHGAP40 TRIO RASGRF2 PARD6A OBSCN IQGAP3	7.50e-04	439	49	7	MM15595
Pathway	BIOCARTA_UCALPAIN_PATHWAY	TLN1 ITGB3	7.64e-04	12	49	2	MM1525
Pathway	REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK	TRIO RASGRF2 OBSCN	7.74e-04	52	49	3	MM14743
Pathway	REACTOME_RHO_GTPASE_CYCLE	ZNF512B ARHGAP40 TRIO RASGRF2 PARD6A OBSCN IQGAP3	8.68e-04	450	49	7	M27078
Pathway	REACTOME_SYNDECAN_INTERACTIONS	ITGA6 ITGB3	1.05e-03	14	49	2	MM14923
Pathway	BIOCARTA_UCALPAIN_PATHWAY	TLN1 ITGB3	1.05e-03	14	49	2	M13143
Pathway	REACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS	ITGA6 LAMC3 ITGB3	1.12e-03	59	49	3	M27218
Pathway	REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK	TRIO RASGRF2 OBSCN	1.12e-03	59	49	3	M11215
Pathway	REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	TLN1 ITGB3	1.21e-03	15	49	2	M12101
Pathway	REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	TLN1 ITGB3	1.21e-03	15	49	2	M1262
Pathway	REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	TLN1 ITGB3	1.21e-03	15	49	2	MM14959
Pathway	REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	TLN1 ITGB3	1.21e-03	15	49	2	MM14961
Pubmed	Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events.	FAM90A14 FAM90A17 FAM90A19 FAM90A23 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10	2.52e-18	25	81	9	17684299
Pubmed	Analysis of the multi-copy gene family FAM90A as a copy number variant in different ethnic backgrounds.	FAM90A14 FAM90A17 FAM90A19 FAM90A23 FAM90A9 FAM90A8 FAM90A16 FAM90A10	2.89e-16	23	81	8	18602769
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ACTR1A TNRC18 SLC38A10 WIZ CHST15 TRIO UBE4B PPRC1 TLN1 SEC16A OBSCN CBLC LAMC3 IRS2 TRRAP IQGAP3 RASAL1	5.75e-10	1105	81	17	35748872
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CSDE1 MBTPS1 LRFN2 CHST15 UBE4B PPRC1 PHF3 TRO TLN1 SEC16A KATNIP	2.87e-09	407	81	11	12693553
Pubmed	Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.	FAM90A14 FAM90A17 FAM90A19 FAM90A23 FAM90A9 FAM90A8 FAM90A10	1.18e-07	164	81	7	22967998
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CSDE1 IRS4 PHF3 TLN1 YLPM1 SEC16A ZC3H18 HEATR1 IPO4 TRRAP DICER1	3.47e-07	653	81	11	22586326
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	ZNF512B OSTC ACTR1A MBTPS1 IRS4 TRIO ZIC5 CWC15 YLPM1 SEC16A ZC3H18 IQGAP3	1.48e-06	922	81	12	27609421
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CSDE1 MBTPS1 BMPR2 TNRC18 LRFN2 TRIO UBE4B MYT1 UVSSA OBSCN SRPK2 KATNIP VPS54 RBBP8NL TRRAP	1.58e-06	1489	81	15	28611215
Pubmed	Distinct frequency patterns of LILRB3 and LILRA6 allelic variants in Europeans.	LILRB3 LILRA6	5.36e-06	2	81	2	36449053
Pubmed	Integrin-bound talin head inhibits actin filament barbed-end elongation.	TLN1 ITGB3	5.36e-06	2	81	2	29276177
Pubmed	The phosphotyrosine binding-like domain of talin activates integrins.	TLN1 ITGB3	5.36e-06	2	81	2	11932255
Pubmed	Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients.	LILRB3 LILRA6	5.36e-06	2	81	2	19617579
Pubmed	Characterization of LILRB3 and LILRA6 allelic variants in the Japanese population.	LILRB3 LILRA6	5.36e-06	2	81	2	33526815
Pubmed	The mechanisms and dynamics of (alpha)v(beta)3 integrin clustering in living cells.	TLN1 ITGB3	5.36e-06	2	81	2	16247034
Pubmed	Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment.	TLN1 ITGB3	5.36e-06	2	81	2	22210111
Pubmed	Structural basis of integrin activation by talin.	TLN1 ITGB3	5.36e-06	2	81	2	17218263
Pubmed	Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail.	TLN1 ITGB3	5.36e-06	2	81	2	10497223
Pubmed	The IRS-signalling system: a network of docking proteins that mediate insulin action.	IRS4 IRS2	5.36e-06	2	81	2	9609109
Pubmed	Diversity of the human LILRB3/A6 locus encoding a myeloid inhibitory and activating receptor pair.	LILRB3 LILRA6	5.36e-06	2	81	2	24096970
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	CSDE1 IRS4 WIZ PHF3 TLN1 YLPM1 SEC16A HEATR1 TRRAP	5.42e-06	549	81	9	38280479
Pubmed	Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3.	TLN1 ITGB3	1.60e-05	3	81	2	18573917
Pubmed	TA205, an anti-talin monoclonal antibody, inhibits integrin-talin interaction.	TLN1 ITGB3	1.60e-05	3	81	2	16546176
Pubmed	Talin-driven inside-out activation mechanism of platelet αIIbβ3 integrin probed by multimicrosecond, all-atom molecular dynamics simulations.	TLN1 ITGB3	1.60e-05	3	81	2	24677266
Pubmed	An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding.	TLN1 ITGB3	1.60e-05	3	81	2	18156175
Pubmed	Direct binding of the platelet integrin alphaIIbbeta3 (GPIIb-IIIa) to talin. Evidence that interaction is mediated through the cytoplasmic domains of both alphaIIb and beta3.	TLN1 ITGB3	1.60e-05	3	81	2	8663236
Pubmed	Minimal amounts of kindlin-3 suffice for basal platelet and leukocyte functions in mice.	TLN1 ITGB3	1.60e-05	3	81	2	26438512
Pubmed	NMR analysis of structure and dynamics of the cytosolic tails of integrin alpha IIb beta 3 in aqueous solution.	TLN1 ITGB3	1.60e-05	3	81	2	11412103
Pubmed	General Anesthesia Decouples Cortical Pyramidal Neurons.	RASGRF2 SST	1.60e-05	3	81	2	32084339
Pubmed	Selective alterations in insulin receptor substrates-1, -2 and -4 in theca but not granulosa cells from polycystic ovaries.	IRS4 IRS2	1.60e-05	3	81	2	15155816
Pubmed	IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis.	IRS4 IRS2	1.60e-05	3	81	2	10594015
Pubmed	A directional switch of integrin signalling and a new anti-thrombotic strategy.	TLN1 ITGB3	1.60e-05	3	81	2	24162846
Pubmed	Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion.	TLN1 ITGB3	1.60e-05	3	81	2	25520155
Pubmed	Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis.	IRS4 IRS2	1.60e-05	3	81	2	24567904
Pubmed	Estrogen-dependent uterine secretion of osteopontin activates blastocyst adhesion competence.	TLN1 ITGA6 ITGB3	2.08e-05	23	81	3	23152823
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	CSDE1 TRIO YLPM1 ITGA6 TMEM30A SRPK2 IRS2	2.09e-05	358	81	7	32460013
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	ACTR1A IRS4 WIZ PHF3 CWC15 TLN1 YLPM1 TRRAP	2.41e-05	506	81	8	30890647
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	WIZ PHF3 CWC15 SRPK2 ZC3H18 DICER1	2.75e-05	251	81	6	28077445
Pubmed	Agonist stimulation, talin-1, and kindlin-3 are crucial for α(IIb)β(3) activation in a human megakaryoblastic cell line, CMK.	TLN1 ITGB3	3.20e-05	4	81	2	23022222
Pubmed	53BP2S, interacting with insulin receptor substrates, modulates insulin signaling.	IRS4 IRS2	3.20e-05	4	81	2	17965023
Pubmed	Structural diversity in integrin/talin interactions.	TLN1 ITGB3	3.20e-05	4	81	2	21134644
Pubmed	Lack of association between markers in the ITGA3, ITGAV, ITGA6 and ITGB3 and autism in an Irish sample.	ITGA6 ITGB3	3.20e-05	4	81	2	21182210
Pubmed	Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin.	TLN1 ITGB3	3.20e-05	4	81	2	12867986
Pubmed	Vinculin regulates assembly of talin: β3 integrin complexes.	TLN1 ITGB3	3.20e-05	4	81	2	24446374
Pubmed	Kindlin-3 is essential for integrin activation and platelet aggregation.	TLN1 ITGB3	3.20e-05	4	81	2	18278053
Pubmed	Cathepsin H mediates the processing of talin and regulates migration of prostate cancer cells.	TLN1 ITGB3	3.20e-05	4	81	2	23204516
Pubmed	A talin mutant that impairs talin-integrin binding in platelets decelerates αIIbβ3 activation without pathological bleeding.	TLN1 ITGB3	3.20e-05	4	81	2	24585775
Pubmed	Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction.	TLN1 ITGB3	5.33e-05	5	81	2	19805288
Pubmed	Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation.	TLN1 ITGB3	5.33e-05	5	81	2	19843520
Pubmed	Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells.	ITGA6 ITGB3	5.33e-05	5	81	2	12364323
Pubmed	Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.	TLN1 ITGB3	5.33e-05	5	81	2	18086863
Pubmed	Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling.	IRS4 IRS2	5.33e-05	5	81	2	18202124
Pubmed	Precise coordination of cell-ECM adhesion is essential for efficient melanoblast migration during development.	TLN1 ITGA6	5.33e-05	5	81	2	32580934
Pubmed	Multiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesis.	ITGA6 LAMC3	5.33e-05	5	81	2	16581764
Pubmed	Association between polymorphisms of microRNA-binding sites in integrin genes and gastric cancer in Chinese Han population.	ITGA6 ITGB3	5.33e-05	5	81	2	25472585
Pubmed	Distinct roles for CARMIL isoforms in cell migration.	TRIO CARMIL3	5.33e-05	5	81	2	19846667
Pubmed	The functional interactome landscape of the human histone deacetylase family.	ZNF512B TNRC18 YLPM1 SEC16A HEATR1 DICER1	6.02e-05	289	81	6	23752268
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	ZNF512B CSDE1 IRS4 WIZ CWC15 TLN1 YLPM1 SEC16A IRS2 HEATR1	6.24e-05	934	81	10	33916271
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	TNRC18 IRS4 TRO DTX1 TLN1 YLPM1 ITGB3	6.66e-05	430	81	7	35044719
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	OSTC SLC38A10 UBE4B MTIF2 ITGA6	7.08e-05	183	81	5	31932471
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	MBTPS1 TRO YLPM1 MPHOSPH9 HEATR1 IQGAP3	7.67e-05	302	81	6	30561431
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	IRS4 PHF3 YLPM1 SEC16A SRPK2 TRRAP DICER1	7.68e-05	440	81	7	34244565
Pubmed	Coordination between extrinsic extracellular matrix cues and intrinsic responses to orient the centrosome in polarizing cerebellar granule neurons.	ITGA6 ITGB3	7.99e-05	6	81	2	20164359
Pubmed	Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker.	ITGA6 ITGB3	7.99e-05	6	81	2	18550570
Pubmed	Talin1 and Rap1 are critical for osteoclast function.	TLN1 ITGB3	7.99e-05	6	81	2	23230271
Pubmed	CD36 associates with CD9 and integrins on human blood platelets.	ITGA6 ITGB3	7.99e-05	6	81	2	11238109
Pubmed	Investigating the role of adrenal cortex in organization and differentiation of the adrenal medulla in mice.	CYP11B2 DICER1	7.99e-05	6	81	2	22580128
Pubmed	Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling.	ITGA6 ITGB3	7.99e-05	6	81	2	28873464
Pubmed	A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1).	ITGA6 ITGB3	7.99e-05	6	81	2	2138612
Pubmed	Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling.	ITGA6 ITGB3	7.99e-05	6	81	2	20682778
Pubmed	Role of integrins during fertilization in mammals.	ITGA6 ITGB3	1.12e-04	7	81	2	10091056
Pubmed	Aldo-keto reductase 1b7, a novel marker for renin cells, is regulated by cyclic AMP signaling.	CYP11B2 DICER1	1.12e-04	7	81	2	26180185
Pubmed	Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling.	ITGA6 ITGB3	1.12e-04	7	81	2	25911094
Pubmed	Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch.	SST ITGB3	1.12e-04	7	81	2	32268102
Pubmed	Integrins are required for the differentiation of visceral endoderm.	ITGA6 ITGB3	1.12e-04	7	81	2	19118216
Pubmed	Differential roles of insulin receptor substrates in brown adipocyte differentiation.	IRS4 IRS2	1.12e-04	7	81	2	14966273
Pubmed	Vision and Locomotion Shape the Interactions between Neuron Types in Mouse Visual Cortex.	RASGRF2 SST	1.12e-04	7	81	2	29656873
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	TRIO SEC16A IPO4 DICER1 IQGAP3	1.13e-04	202	81	5	33005030
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	IRS4 YLPM1 ZC3H18 HEATR1 IQGAP3	1.13e-04	202	81	5	24639526
Pubmed	Bridging expressed sequence alignments through targeted cDNA sequencing.	CARMIL3 HEATR1	1.49e-04	8	81	2	15028280
Pubmed	Knockout and knockin of the beta1 exon D define distinct roles for integrin splice variants in heart function and embryonic development.	ITGA6 ITGB3	1.49e-04	8	81	2	9553049
Pubmed	Developmental regulation of integrin expression at the time of implantation in the mouse embryo.	ITGA6 ITGB3	1.49e-04	8	81	2	8306881
Pubmed	Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation.	TLN1 ITGB3	1.49e-04	8	81	2	8631894
Pubmed	Layer 6b Is Driven by Intracortical Long-Range Projection Neurons.	RASGRF2 SST	1.49e-04	8	81	2	32160552
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CSDE1 OSTC ACTR1A WIZ PHF3 TLN1 SRPK2 HEATR1 IPO4 TRRAP DICER1 IQGAP3	1.75e-04	1497	81	12	31527615
Pubmed	Comparative phenotypic analysis of the two major splice isoforms of phosphatidylinositol phosphate kinase type Iγ in vivo.	TLN1 ITGA6	1.91e-04	9	81	2	22976293
Pubmed	Characterization of integrin engagement during defined human embryonic stem cell culture.	ITGA6 ITGB3	1.91e-04	9	81	2	19933311
Pubmed	IRS2 signalling is required for the development of a subset of sensory spinal neurons.	IRS4 IRS2	1.91e-04	9	81	2	22288475
Pubmed	Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8.	ITGA6 ITGB3	1.91e-04	9	81	2	1693624
Pubmed	Intensified antineoplastic effect by combining an HDAC-inhibitor, an mTOR-inhibitor and low dosed interferon alpha in prostate cancer cells.	ITGA6 ITGB3	1.91e-04	9	81	2	25808196
Pubmed	Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits.	TLN1 ITGB3	1.91e-04	9	81	2	11807098
Pubmed	Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer.	IRS4 IRS2	2.38e-04	10	81	2	20416304
Pubmed	Identification of putative retinoic acid target genes downstream of mesenchymal Tbx1 during inner ear development.	MYT1 ITGB3	2.38e-04	10	81	2	22275070
Pubmed	Insulin-like growth factor axis gene polymorphisms modify risk of pancreatic cancer.	IRS4 IRS2	2.38e-04	10	81	2	21852217
Pubmed	Trophoblast-specific expression and function of the integrin alpha 7 subunit in the peri-implantation mouse embryo.	ITGA6 LAMC3	2.38e-04	10	81	2	11784026
Pubmed	WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation.	UBE4B MAP3K6 ITGB3	2.48e-04	52	81	3	30655611
Pubmed	SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.	IRS4 IRS2	2.91e-04	11	81	2	12052866
Pubmed	Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.	MBTPS1 IRS4 PPRC1 CYP11B2 IRS2	3.03e-04	250	81	5	18660489
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	TRIO PHF3 CWC15 YLPM1 SEC16A TMEM30A MPHOSPH9 DICER1	3.11e-04	733	81	8	34672954
Pubmed	Convergence of bone morphogenetic protein and laminin-1 signaling pathways promotes proliferation and colony formation by fetal mouse pancreatic cells.	BMPR2 ITGA6	3.48e-04	12	81	2	15913604
Pubmed	Knock-in of diphteria toxin A chain gene at Ins2 locus: effects on islet development and localization of Ins2 expression in the brain.	IRS2 SST	3.48e-04	12	81	2	15587270
Interaction	TOP3B interactions	CSDE1 ACTR1A TNRC18 SLC38A10 WIZ CHST15 TRIO UBE4B PPRC1 TLN1 SEC16A OBSCN CBLC LAMC3 IRS2 IPO4 TRRAP IQGAP3 RASAL1	4.93e-07	1470	71	19	int:TOP3B
Interaction	TNIP2 interactions	ZNF512B OSTC ACTR1A MBTPS1 IRS4 TRIO ZIC5 MAP3K8 CWC15 TRO YLPM1 SEC16A SRPK2 ZC3H18	4.87e-06	952	71	14	int:TNIP2
Cytoband	8p23.1	FAM90A14 FAM90A17 FAM90A19 FAM90A23 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10	9.01e-12	154	81	9	8p23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr8p23	FAM90A14 FAM90A17 FAM90A19 FAM90A23 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10	3.77e-10	234	81	9	chr8p23
Cytoband	20q13.33	ZNF512B MYT1 RBBP8NL	3.80e-04	79	81	3	20q13.33
Cytoband	1p22	CSDE1 ABCA4	5.72e-04	20	81	2	1p22
Cytoband	10q24.32	ACTR1A PPRC1	8.27e-04	24	81	2	10q24.32
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	TRIO RASGRF2 OBSCN	8.06e-04	66	50	3	722
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	MAP3K8 MAP3K6	1.99e-03	24	50	2	654
Disease	leukocyte immunoglobulin-like receptor subfamily A member 6 measurement	LILRB3 LILRA6	7.80e-05	6	68	2	EFO_0801767
Disease	leukocyte immunoglobulin-like receptor subfamily B member 3 measurement	LILRB3 LILRA6	7.80e-05	6	68	2	EFO_0802705
Disease	amnestic disorder (implicated_via_orthology)	IRS4 IRS2	1.86e-04	9	68	2	DOID:10914 (implicated_via_orthology)
Disease	childhood trauma measurement, alcohol consumption measurement	PCDHGC4 ITGA6 SLCO6A1	5.98e-04	71	68	3	EFO_0007878, EFO_0007979
Disease	Autism Spectrum Disorders	LAMC3 ITGB3 IQGAP3	1.01e-03	85	68	3	C1510586
Disease	glucose metabolism disease (implicated_via_orthology)	IRS4 IRS2	1.90e-03	28	68	2	DOID:4194 (implicated_via_orthology)
Disease	cytotoxicity measurement, response to clozapine	CHST15 MYT1	2.04e-03	29	68	2	EFO_0006952, GO_0097338

Protein segments in the cluster

Peptide	Gene	Start	Entry
NLEAKSRQVAALLPP	CBLC	86	Q9ULV8
TPDSPAARRILKNAN	ABCA4	401	P78363
AAPRPDRLVNRLKNI	CSDE1	746	O75534
KIRDLPFTRNNLAPL	ANKRD55	556	Q3KP44
PAKDPLDRRLQNLRD	ZNF436-AS1	26	Q8NC38
KKPRLDQIPAANLDA	CWC15	91	Q9P013
RRALRSLKANQPQVP	DICER1	1906	Q9UPY3
LQAARPQAQDKRPAV	FAM90A10	251	A6NDY2
ALRKASAPNPNKLAA	RASAL1	666	O95294
RSNAPNIPKLNRFLL	OSTC	106	Q9NRP0
LQAARPQAQDKRPAV	FAM90A23	251	A8MXZ1
DLDKVVLPNFRSNRP	MBTPS1	956	Q14703
KNKDAVRRPQADPAL	MTIF2	161	P46199
RALLSRKAEQPASPL	KATNIP	356	O60303
FPERTLPARNAKLQD	CARMIL3	1256	Q8ND23
NRPGDRAKALSVLLP	MAP3K6	326	O95382
RPRAADLLKHEALNP	MAP3K8	376	P41279
LQAARPQAQDKRPAV	FAM90A14	251	P0C7W9
NRLDDVRNRFKLPPQ	HAO1	166	Q9UJM8
RTNPRKQLQFLPLDD	MPHOSPH9	876	Q99550
RNNPLEPKNKARFSI	LILRA6	71	Q6PI73
RNNPLEPKNKARFSI	LILRB3	71	O75022
APRAEALPLQRANRT	ITGA6	66	P23229
LQAARPQAQDKRPAV	FAM90A17	251	P0DV74
LDLNDNAPAVLRPRA	PCDHGC4	556	Q9Y5F7
LQAARPQAQDKRPAV	FAM90A16	251	P0DV73
NAILASQRRKAPPAP	DTX1	216	Q86Y01
LQAARPQAQDKRPAV	FAM90A19	251	P0DV76
RQSPEALLKALQDPA	IQGAP3	306	Q86VI3
NKPPAAAAREVLARL	OBSCN	706	Q5VST9
DFIKATLQRAPQARP	OBSCN	6696	Q5VST9
PPLRLLVQKRAEADS	PARD6A	86	Q9NPB6
LQAARPQAQDKRPAV	FAM90A8	251	A6NJQ4
PKQILQPRAAAAAAA	IRS2	686	Q9Y4H2
AAAPSDPRLQDLKAR	RBBP8NL	311	Q8NC74
DPRSNDLARVPLKLS	C6orf15	66	Q6UXA7
KPRRAQRPNSLDLSA	BMPR2	931	Q13873
TEAPLNPRKNRERAA	ACTR1A	111	P61163
RRPDNTAFKQQRLPA	TMEM30A	26	Q9NV96
PQRIALRLRPDDSKN	ITGB3	111	P05106
PLPSVRRKALDLLNN	HEATR1	1611	Q9H583
RLRLNPDVLSPKAVQ	CYP11B2	141	P19099
LQAARPQAQDKRPAV	FAM90A5P	251	A8MXJ8
RPDNAKPNRDLKLQA	SLC38A10	1031	Q9HBR0
QLLRNPSSPRAKELA	IPO4	486	Q8TEX9
KRPLDRLQAPELANV	PPRC1	1211	Q5VV67
PANDLSDLLRAIPRA	IRS4	971	O14654
PRNLRSPAEDKILAV	OR2L13	261	Q8N349
AERRGLNLAPSPANK	NUTM2D	731	Q5VT03
AAAQKQAKRRNPDSP	MRPS15	231	P82914
PQEAQKLAAERARAP	UVSSA	486	Q2YD98
LDPQKFTRAALPAVR	NKX1-2	26	Q9UD57
LRDPDLLPQERKAAA	RASGRF2	951	O14827
LPPNASALFRKLENV	FASTKD3	421	Q14CZ7
NAALREKLALLPPQA	PPP1R35	176	Q8TAP8
LQAARPQAQDKRPAV	FAM90A9	251	A6NNJ1
LQAARPQAQDKRPAV	FAM90A13P	251	P0C7W8
PLEAARAQPAKDRRA	SLCO6A1	21	Q86UG4
NINKFERRQARPPDA	WIZ	1531	O95785
LQAARPQAQDKRPAV	FAM90A15P	251	P0C7V4
KSPASNARRPEDRNL	CHST15	511	Q7LFX5
SVENRPKIAAFLPAR	TNRC18	2771	O15417
ILPEPNRNALKALLE	ARHGAP40	391	Q5TG30
RQKQCRPAAALPDAS	SEC16A	641	O15027
APPRDVAILQERANK	TRO	436	Q12816
KQRLLIISAPDPSNR	SRPX2	341	O60687
PAAPNLKSQLAAAAR	TLN1	1326	Q9Y490
PIAAAARSPDRNLLL	UBE4B	231	O95155
LLVNPLDPRNADKIR	SRPK2	511	P78362
RSPQFINLKRDPRQA	PHF3	1641	Q92576
LEFAPKAVLNRNRPE	SMIM12	76	Q96EX1
QDKGLPRPDNRDNRL	YLPM1	996	P49750
RPKAENQALRDIPLS	ZNF512B	76	Q96KM6
KALLVALSRRPQAAP	TTC34	71	A8MYJ7
DARPLRDVLAANPNR	TRRAP	1596	Q9Y4A5
KQASEPALRKRNFLP	nan	46	Q96M66
PSDPRLRQFLQKSLA	SST	26	P61278
LQEDPAKRPSAALAL	TRIO	3031	O75962
VNLPAALNDPRLAKR	VPS54	71	Q9P1Q0
APAAPADRKRQLSPQ	ZC3H18	881	Q86VM9
KRNPPALRLADLATA	ZIC5	31	Q96T25
PLAAKRALQARPDIN	TMPPE	371	Q6ZT21
LQAARPQAQDKRPAV	FAM90A18	251	P0DV75
KLQFPRPKDQAALQR	LAMC3	1346	Q9Y6N6
RLDLTSNRLQKLPPD	LRFN2	201	Q9ULH4
RPNVAPATPRANLAK	MYT1	561	Q01538