Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

IARS1 FTSJ1 ZNFX1 DCLRE1B DICER1 DDX1 DUS1L DHX30 DUS2 PDE12 MARF1 POLQ NIPBL DDX4 TDRD12 REV1

2.07e-0564514616GO:0140640
GeneOntologyMolecularFunctionhelicase activity

ZNFX1 DICER1 DDX1 DHX30 POLQ DDX4 TDRD12

1.64e-041581467GO:0004386
GeneOntologyMolecularFunctionATP-dependent activity

ABCF1 ABCA4 DNAH10 MYO9A MYO9B SMCHD1 ZNFX1 DICER1 DDX1 DHX30 SHOC1 POLQ DDX4 TDRD12

1.69e-0461414614GO:0140657
GeneOntologyMolecularFunctioncatalytic activity, acting on RNA

IARS1 FTSJ1 DICER1 DDX1 DUS1L DHX30 DUS2 PDE12 MARF1 DDX4 TDRD12

2.54e-0441714611GO:0140098
GeneOntologyMolecularFunctionnuclease activity

REXO5 DCLRE1B DICER1 NME8 DDX1 PDE12 MARF1 POLQ

3.05e-042311468GO:0004518
GeneOntologyMolecularFunctiontRNA dihydrouridine synthase activity

DUS1L DUS2

3.16e-0441462GO:0017150
GeneOntologyMolecularFunctionRNA dihydrouridine synthase activity

DUS1L DUS2

3.16e-0441462GO:0106413
GeneOntologyMolecularFunctionATP hydrolysis activity

ABCF1 ABCA4 DNAH10 MYO9B SMCHD1 DDX1 DHX30 SHOC1 POLQ DDX4 TDRD12

4.08e-0444114611GO:0016887
GeneOntologyMolecularFunctionpyrophosphatase activity

ABCF1 ABCA4 DNAH10 MYO9B SMCHD1 TRPM2 DDX1 DHX30 RABL2B RABL2A SHOC1 POLQ DDX4 RAC1 RAC3 TDRD12

4.33e-0483914616GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

ABCF1 ABCA4 DNAH10 MYO9B SMCHD1 TRPM2 DDX1 DHX30 RABL2B RABL2A SHOC1 POLQ DDX4 RAC1 RAC3 TDRD12

4.38e-0484014616GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

ABCF1 ABCA4 DNAH10 MYO9B SMCHD1 TRPM2 DDX1 DHX30 RABL2B RABL2A SHOC1 POLQ DDX4 RAC1 RAC3 TDRD12

4.38e-0484014616GO:0016818
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

ABCF1 ABCA4 DNAH10 MYO9B SMCHD1 DDX1 DHX30 RABL2B RABL2A SHOC1 POLQ DDX4 RAC1 RAC3 TDRD12

5.65e-0477514615GO:0017111
GeneOntologyMolecularFunctionexonuclease activity

REXO5 DCLRE1B NME8 DDX1 PDE12

5.76e-04921465GO:0004527
GeneOntologyBiologicalProcessdouble-strand break repair

SHLD2 SMCHD1 DCLRE1B TRRAP DDX1 BABAM1 MARF1 ZFYVE26 POLQ NIPBL TP53BP1

1.89e-0532414511GO:0006302
GeneOntologyBiologicalProcessDNA metabolic process

CFH SHLD2 CTC1 PARK7 SMCHD1 DCLRE1B TRRAP DICER1 DDX1 BABAM1 MDC1 NAT10 MARF1 SHOC1 TAOK1 ZFYVE26 POLQ NIPBL TP53BP1 RAC1 REV1

2.23e-05108114521GO:0006259
GeneOntologyBiologicalProcessnegative regulation of double-strand break repair via homologous recombination

SHLD2 SMCHD1 POLQ TP53BP1

3.11e-05261454GO:2000042
GeneOntologyBiologicalProcesscell chemotaxis

MYO9B CXCL10 TRPM2 PLEKHG5 PIKFYVE ALOX5 JAM3 RAC1 RAC3 TPBG VEGFB

5.33e-0536314511GO:0060326
GeneOntologyBiologicalProcessDNA repair

SHLD2 PARK7 SMCHD1 DCLRE1B TRRAP DDX1 BABAM1 MDC1 MARF1 TAOK1 ZFYVE26 POLQ NIPBL TP53BP1 REV1

5.34e-0564814515GO:0006281
GeneOntologyCellularComponentparanodal junction

ANK2 SPTBN2 JAM3

5.50e-05111483GO:0033010
GeneOntologyCellularComponentribonucleoprotein granule

SYNE1 ZNFX1 EDC4 RBM20 DDX1 DHX30 DDX4 RAC1 GABPB1

2.12e-042871489GO:0035770
GeneOntologyCellularComponentSec61 translocon complex

SEC61A2 SEC61A1

4.91e-0451482GO:0005784
GeneOntologyCellularComponentcytoplasmic ribonucleoprotein granule

SYNE1 ZNFX1 EDC4 RBM20 DDX1 DDX4 RAC1 GABPB1

6.77e-042691488GO:0036464
GeneOntologyCellularComponenttranslocon complex

SEC61A2 SEC61A1

7.33e-0461482GO:0071256
GeneOntologyCellularComponentsite of double-strand break

SHLD2 SMCHD1 MDC1 POLQ TP53BP1

7.63e-041011485GO:0035861
GeneOntologyCellularComponentperinuclear region of cytoplasm

ANK2 SLC17A3 MYO9B SYNE1 PARK7 SPTBN2 FSD2 TRIM68 PLEKHG5 DICER1 PIKFYVE PLAAT3 TAOK1 ALOX5 DDX4 RAC3

9.72e-0493414816GO:0048471
GeneOntologyCellularComponentpericentriolar material

RABL2B RABL2A RAC1

1.00e-03281483GO:0000242
GeneOntologyCellularComponentsperm midpiece

NME8 FSIP2 RABL2B RABL2A

1.10e-03641484GO:0097225
MousePhenoabnormal QT interval

ANK2 BTNL8 SYNE1 FSD2 RBM20 PHACTR4 SSH2

6.35e-06781267MP:0003899
DomainP-loop_NTPase

DLG5 ABCF1 ABCA4 DNAH10 MYO9A MYO9B ZNFX1 DICER1 DDX1 DHX30 RABL2B NWD2 RABL2A HNRNPUL2 POLQ NLRP4 DDX4 RAC1 RAC3 TDRD12

1.12e-0584814720IPR027417
Domain-

DLG5 ABCF1 ABCA4 DNAH10 ZNFX1 DICER1 DDX1 DHX30 RABL2B NWD2 RABL2A HNRNPUL2 POLQ NLRP4 DDX4 RAC1 RAC3 TDRD12

2.37e-05746147183.40.50.300
DomainDEAD/DEAH_box_helicase_dom

DICER1 DDX1 DHX30 POLQ DDX4 TDRD12

2.37e-05731476IPR011545
DomainDEAD

DICER1 DDX1 DHX30 POLQ DDX4 TDRD12

2.37e-05731476PF00270
DomainSecY_su_dom

SEC61A2 SEC61A1

6.15e-0521472IPR023201
DomainSECY_1

SEC61A2 SEC61A1

6.15e-0521472PS00755
DomainSECY_2

SEC61A2 SEC61A1

6.15e-0521472PS00756
Domain-

SEC61A2 SEC61A1

6.15e-05214721.10.3370.10
DomainTranslocon_Sec61/SecY_plug_dom

SEC61A2 SEC61A1

6.15e-0521472IPR019561
DomainSecY_CS

SEC61A2 SEC61A1

6.15e-0521472IPR030659
DomainPlug_translocon

SEC61A2 SEC61A1

6.15e-0521472PF10559
DomainSecY

SEC61A2 SEC61A1

6.15e-0521472PF00344
DomainSecY/SEC61-alpha

SEC61A2 SEC61A1

6.15e-0521472IPR002208
DomainSPRY

BTNL8 FSD2 TRIM77 TRIM68 DDX1 HNRNPUL2

9.89e-05941476PF00622
DomainSPRY_dom

BTNL8 FSD2 TRIM77 TRIM68 DDX1 HNRNPUL2

9.89e-05941476IPR003877
DomainB30.2/SPRY

BTNL8 FSD2 TRIM77 TRIM68 DDX1 HNRNPUL2

1.05e-04951476IPR001870
DomainB302_SPRY

BTNL8 FSD2 TRIM77 TRIM68 DDX1 HNRNPUL2

1.05e-04951476PS50188
DomaintRNA_hU_synthase_CS

DUS1L DUS2

3.65e-0441472IPR018517
DomaintRNA_hU_synthase

DUS1L DUS2

3.65e-0441472IPR001269
DomainUPF0034

DUS1L DUS2

3.65e-0441472PS01136
DomainDus

DUS1L DUS2

3.65e-0441472PF01207
DomainBRCT

MDC1 TP53BP1 REV1

4.22e-04191473PF00533
Domaindsrm

DICER1 DHX30 DUS2

4.94e-04201473PF00035
DomainDS_RBD

DICER1 DHX30 DUS2

5.73e-04211473PS50137
DomainSPRY

BTNL8 FSD2 TRIM68 DDX1 HNRNPUL2

6.21e-04871475SM00449
DomainBRCT

MDC1 TP53BP1 REV1

6.59e-04221473SM00292
DomainSpectrin

SYNE1 SPTBN2 UTRN

7.54e-04231473PF00435
DomainACTININ_2

SYNE1 SPTBN2 UTRN

7.54e-04231473PS00020
DomainACTININ_1

SYNE1 SPTBN2 UTRN

7.54e-04231473PS00019
Domain-

MDC1 TP53BP1 REV1

7.54e-042314733.40.50.10190
DomainActinin_actin-bd_CS

SYNE1 SPTBN2 UTRN

7.54e-04231473IPR001589
DomainBRCT

MDC1 TP53BP1 REV1

1.09e-03261473PS50172
Domain-

DICER1 DUS2 MRPS5

1.22e-032714733.30.160.20
DomaindsRBD_dom

DICER1 DUS2 MRPS5

1.35e-03281473IPR014720
DomainBRCT_dom

MDC1 TP53BP1 REV1

1.35e-03281473IPR001357
DomainSpectrin_repeat

SYNE1 SPTBN2 UTRN

1.50e-03291473IPR002017
DomainHelicase_C

DICER1 DDX1 DHX30 POLQ DDX4

1.58e-031071475PF00271
DomainHELICc

DICER1 DDX1 DHX30 POLQ DDX4

1.58e-031071475SM00490
DomainHelicase_C

DICER1 DDX1 DHX30 POLQ DDX4

1.64e-031081475IPR001650
DomainHELICASE_CTER

DICER1 DDX1 DHX30 POLQ DDX4

1.71e-031091475PS51194
DomainHELICASE_ATP_BIND_1

DICER1 DDX1 DHX30 POLQ DDX4

1.71e-031091475PS51192
DomainDEXDc

DICER1 DDX1 DHX30 POLQ DDX4

1.71e-031091475SM00487
DomainConA-like_dom

BTNL8 FAT3 FSD2 TRIM77 TRIM68 DDX1 HNRNPUL2

1.76e-032191477IPR013320
DomainHelicase_ATP-bd

DICER1 DDX1 DHX30 POLQ DDX4

1.78e-031101475IPR014001
DomainSPEC

SYNE1 SPTBN2 UTRN

2.00e-03321473SM00150
DomainSpectrin/alpha-actinin

SYNE1 SPTBN2 UTRN

2.00e-03321473IPR018159
DomainTransglut_N

TGM6 TGM1

2.14e-0391472PF00868
DomainTRANSGLUTAMINASES

TGM6 TGM1

2.14e-0391472PS00547
Domain-

TGM6 TGM1

2.14e-03914723.90.260.10
DomainGln_gamma-glutamylTfrase_euk

TGM6 TGM1

2.14e-0391472IPR023608
DomainTransglutaminase_AS

TGM6 TGM1

2.14e-0391472IPR013808
DomainTransglutaminase_N

TGM6 TGM1

2.14e-0391472IPR001102
DomainTransglut_C

TGM6 TGM1

2.14e-0391472PF00927
DomainButyrophylin

BTNL8 FSD2 TRIM77 TRIM68

2.26e-03701474IPR003879
Pubmed

Human transcription factor protein interaction networks.

TCF20 DNAH10 IARS1 SMCHD1 TPGS1 EDC4 ECH1 TRRAP RBM20 DDX1 TFE3 DHX30 NIFK FBN1 GSE1 ATXN1 HNRNPUL2 MDC1 NAT10 MARF1 MRPS5 RERE NIPBL TP53BP1 HOMEZ DCAF7

6.81e-1014291522635140242
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MON2 UNC13B CTC1 MYO9B EDC4 RALGAPA2 TRRAP STK11IP BIRC6 PLEKHG5 DUS1L TFE3 DHX30 TAOK2 PIKFYVE PKD1 ZFYVE26 DNMBP ALOX5 GAREM1

8.45e-0811051522035748872
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

ABCF1 TCF20 MYO9A MYO9B IARS1 PARK7 SMCHD1 ECH1 TRRAP BIRC6 DDX1 DHX30 TGM1 NIFK PDE12 HNRNPUL2 MDC1 NAT10 DHRS2 UTRN NIPBL TP53BP1

1.16e-0713531522229467282
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

ABCF1 TCF20 MYO9B IARS1 SYNE1 SMCHD1 SPTBN2 EDC4 TRRAP DICER1 DDX1 DHX30 CEP350 NIFK HNRNPUL2 MDC1 NAT10 UTRN NIPBL

1.25e-0710241521924711643
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

ABCF1 TCF20 SMCHD1 SPTBN2 EDC4 TRRAP BIRC6 DICER1 DHX30 NIFK MDC1 NAT10 UTRN NIPBL TP53BP1

2.03e-076531521522586326
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

FNBP1 ABCF1 TCF20 DOCK8 IARS1 SMCHD1 EDC4 TRRAP DDX1 NIFK GSE1 NIPBL MVK TP53BP1 RAC1 GABPB1 HOMEZ KNL1 DCAF7

3.88e-0711031521934189442
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

UNC13B CFH ABCF1 ANK2 SYNE1 SPTBN2 ZNFX1 CACHD1 TRIM68 INTS8 DHX30 CEP350 PLAAT3 FBN1 PKD1 ASTN2 TAOK1 ANKRD36 UTRN NIPBL

9.11e-0712851522035914814
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

ABCF1 ANK2 ACTR3C MYO9A DOCK8 IARS1 SYNE1 PARK7 SPTBN2 TPGS1 ZNFX1 EDC4 PLEKHG5 DDX1 DHX30 TGM1 NWD2 HNRNPUL2 SSH2 UTRN RAC1

1.21e-0614311522137142655
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

MON2 DLG5 MYO9A MYO9B PARK7 RBM20 DDX1 PIKFYVE BABAM1 GSE1 DNMBP TP53BP1 KNL1

2.08e-065881521338580884
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

DLG5 ABCF1 ANK2 SYNE1 PARK7 SPTBN2 DNAJC21 FTSJ1 ECH1 DICER1 DHX30 SEC61A2 NIFK SENP1 PDE12 NAT10 PHACTR4 MRPS5 SEC61A1 TP53BP1 DCAF7

2.22e-0614871522133957083
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

UNC13B DLG5 ANK2 SMCHD1 SPTBN2 TRPM2 FTSJ1 F2 ECH1 DICER1 TAOK2 CEP350 DUS2 NIFK NAT10 MARF1 TAOK1 DHRS2 RAC1 DCAF7

2.44e-0613711522036244648
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

DLG5 ABCF1 DCTN5 SYNE1 DNAJC21 EDC4 TRRAP INTS8 DICER1 DHX30 TAOK2 NIFK BABAM1 MDC1 MRPS5 DHRS2 DNMBP UTRN NIPBL RAC1 DCAF7

2.47e-0614971522131527615
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

TCF20 SMCHD1 EDC4 TRRAP INTS8 TAOK2 SENP1 GSE1 MDC1 TP53BP1

2.82e-063411521032971831
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

ABCF1 DNAH10 IARS1 SYNE1 PARK7 SMCHD1 EDC4 F2 DICER1 DDX1 DHX30 NIFK PDE12 HNRNPUL2 MDC1 NAT10 SEC61A1 NIPBL RAC1 DCAF7

4.35e-0614251522030948266
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TCF20 ANK2 SYNE1 PARK7 SPTBN2 ZNFX1 EDC4 TAOK2 SENP1 HNRNPUL2 NAT10 SSH2 NIPBL TP53BP1 RAC1 DCAF7

5.39e-069631521628671696
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

TCF20 SMCHD1 TRRAP DDX1 GSE1 HNRNPUL2 RERE DCAF7

6.06e-06220152835785414
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

DLG5 TCF20 MYO9A TRIM68 EDC4 DDX1 CEP350 FSIP2 ATXN1 PHACTR4 SSH2 DNMBP UTRN ARAP2 DCAF7

6.15e-068611521536931259
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

FNBP1 ABCF1 TCF20 TRRAP MTAP GSE1 MDC1 PHACTR4 TAOK1 RERE DNMBP NIPBL TP53BP1 HOMEZ

8.36e-067741521415302935
Pubmed

Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy.

ABCF1 IARS1 SMCHD1 DDX1 DHX30 HNRNPUL2

8.82e-06109152629511296
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

SYNE1 TPGS1 ECH1 BIRC6 RBM20 DHX30 PIKFYVE SEC61A2 NIFK SENP1 PDE12 BABAM1 HNRNPUL2 NAT10 MRPS5 MINDY4 RERE SEC61A1 DDX4 CYB5R1

8.90e-0614961522032877691
Pubmed

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

FNBP1 DNAH10 SYNE1 PARK7 CCDC168 BIRC6 FSIP2

9.73e-06168152730631154
Pubmed

53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in.

SHLD2 CTC1 TP53BP1

1.32e-0511152330022158
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MON2 UNC13B FNBP1 TCF20 SYNE1 HEATR5A DHX30 GSE1 RERE ARAP2

1.32e-054071521012693553
Pubmed

HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.

TRRAP DICER1 UTRN DDX4

1.47e-0534152425925205
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

ABCF1 IARS1 SMCHD1 EDC4 DDX1 MDC1 NAT10 NIPBL TP53BP1

1.68e-05332152932786267
Pubmed

The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.

CEP350 RABL2B RABL2A

1.75e-0512152328625565
Pubmed

An improved smaller biotin ligase for BioID proximity labeling.

TCF20 CCDC168 FSIP2 SENP1 FBN1 MDC1

1.76e-05123152626912792
Pubmed

DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours.

MDC1 TP53BP1

1.90e-052152217546051
Pubmed

Expression dynamics of HAND1/2 in in vitro human cardiomyocyte differentiation.

HAND1 HAND2

1.90e-052152234297940
Pubmed

Rac-deficient cerebellar granule neurons die before they migrate to the internal granule layer.

RAC1 RAC3

1.90e-052152236050459
Pubmed

Rac1 and Rac3 have opposite functions in Schwann cells during developmental myelination.

RAC1 RAC3

1.90e-052152233812927
Pubmed

A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13.

UNC13B SPTBN2

1.90e-05215229704016
Pubmed

Identification of a Protein Network Driving Neuritogenesis of MGE-Derived GABAergic Interneurons.

RAC1 RAC3

1.90e-052152228066185
Pubmed

RABL2 Is Required for Hepatic Fatty Acid Homeostasis and Its Dysfunction Leads to Steatosis and a Diabetes-Like State.

RABL2B RABL2A

1.90e-052152227732084
Pubmed

The in vivo dynamic interplay of MDC1 and 53BP1 at DNA damage-induced nuclear foci.

MDC1 TP53BP1

1.90e-052152222677490
Pubmed

Dispensable role of Rac1 and Rac3 after cochlear hair cell specification.

RAC1 RAC3

1.90e-052152237204479
Pubmed

HAND proteins: molecular mediators of cardiac development and congenital heart disease.

HAND1 HAND2

1.90e-052152210189962
Pubmed

Rac1 and Rac3 GTPases differently influence the morphological maturation of dendritic spines in hippocampal neurons.

RAC1 RAC3

1.90e-052152231369617
Pubmed

Analysis of relative gene dosage and expression differences of the paralogs RABL2A and RABL2B by Pyrosequencing.

RABL2B RABL2A

1.90e-052152220138207
Pubmed

The direct interaction between 53BP1 and MDC1 is required for the recruitment of 53BP1 to sites of damage.

MDC1 TP53BP1

1.90e-052152218986980
Pubmed

Prenatal alcohol exposure causes the over-expression of DHAND and EHAND by increasing histone H3K14 acetylation in C57 BL/6 mice.

HAND1 HAND2

1.90e-052152224857828
Pubmed

Expression and regulation of eHAND during limb development.

HAND1 HAND2

1.90e-052152212666206
Pubmed

A subclass of bHLH proteins required for cardiac morphogenesis.

HAND1 HAND2

1.90e-05215228533092
Pubmed

Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1.

MDC1 TP53BP1

1.90e-052152216009723
Pubmed

Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) promotes non-homologous end joining and inhibits homologous recombination repair upon DNA damage.

SMCHD1 TP53BP1

1.90e-052152225294876
Pubmed

A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay.

EDC4 MARF1

1.90e-052152232510323
Pubmed

Rac1 and Rac3 GTPases regulate the development of hilar mossy cells by affecting the migration of their precursors to the hilus.

RAC1 RAC3

1.90e-052152221949760
Pubmed

Downregulation of MDC1 and 53BP1 by short hairpin RNA enhances radiosensitivity in laryngeal carcinoma cells.

MDC1 TP53BP1

1.90e-052152225976740
Pubmed

Loss of Either Rac1 or Rac3 GTPase Differentially Affects the Behavior of Mutant Mice and the Development of Functional GABAergic Networks.

RAC1 RAC3

1.90e-052152226582364
Pubmed

Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome.

SEC61A2 SEC61A1

1.90e-052152218480044
Pubmed

Rac-Dependent Signaling from Keratinocytes Promotes Differentiation of Intradermal White Adipocytes.

RAC1 RAC3

1.90e-052152231351086
Pubmed

Class IX Myosins: Motorized RhoGAP Signaling Molecules.

MYO9A MYO9B

1.90e-052152232451867
Pubmed

A HANDful of questions: the molecular biology of the heart and neural crest derivatives (HAND)-subclass of basic helix-loop-helix transcription factors.

HAND1 HAND2

1.90e-052152212909338
Pubmed

TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1.

TRPM2 RAC1

1.90e-052152225295536
Pubmed

Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion.

RAC1 RAC3

1.90e-052152216027728
Pubmed

Role of transient receptor potential cation channel subfamily M member 2 in hepatic ischemia-reperfusion injury in the mouse and the underlying mechanisms.

TRPM2 RAC1

1.90e-052152232879079
Pubmed

Human Dicer C-terminus functions as a 5-lipoxygenase binding domain.

DICER1 ALOX5

1.90e-052152219022417
Pubmed

Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair.

MDC1 TP53BP1

1.90e-052152218158901
Pubmed

Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells.

RAC1 RAC3

1.90e-052152216280046
Pubmed

RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells.

RAC1 RAC3

1.90e-052152236599922
Pubmed

[Expression of DNA damage checkpoint mediator 1 and p53-binding protein 1 in human esophageal cancer cell lines TE-1, TE-13, and Eca109].

MDC1 TP53BP1

1.90e-052152217884766
Pubmed

Absence of Rac1 and Rac3 GTPases in the nervous system hinders thymic, splenic and immune-competence development.

RAC1 RAC3

1.90e-052152221469092
Pubmed

Rac1 and Rac3 have opposing functions in cell adhesion and differentiation of neuronal cells.

RAC1 RAC3

1.90e-052152217244648
Pubmed

Two novel human RAB genes with near identical sequence each map to a telomere-associated region: the subtelomeric region of 22q13.3 and the ancestral telomere band 2q13.

RABL2B RABL2A

1.90e-052152210444334
Pubmed

HAND1 and HAND2 are expressed in the adult-rodent heart and are modulated during cardiac hypertrophy.

HAND1 HAND2

1.90e-052152212359233
Pubmed

Variants in RABL2A causing male infertility and ciliopathy.

RABL2B RABL2A

1.90e-052152233075816
Pubmed

Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells.

TAOK2 TAOK1

1.90e-052152228830982
Pubmed

HAND transcription factors are required for neonatal sympathetic neuron survival.

HAND1 HAND2

1.90e-052152218724272
Pubmed

Perivascular deletion of murine Rac reverses the ratio of marrow arterioles and sinusoid vessels and alters hematopoiesis in vivo.

RAC1 RAC3

1.90e-052152225824687
Pubmed

RABL2 positively controls localization of GPCRs in mammalian primary cilia.

RABL2B RABL2A

1.90e-052152230578315
Pubmed

Role of Rac 1 and cAMP in endothelial barrier stabilization and thrombin-induced barrier breakdown.

F2 RAC1

1.90e-052152219472214
Pubmed

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.

DLG5 ABCF1 IARS1 SYNE1 SPTBN2 DNAJC21 DDX1 DHX30 TGM1 NIFK SENP1 HNRNPUL2 MDC1 NAT10 SEC61A1

1.93e-059491521536574265
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

DLG5 DNAH10 SYNE1 TRRAP PKD1 ANKRD36 SSH2

1.95e-05187152726460568
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

DLG5 ABCF1 TCF20 SYNE1 SPTBN2 FTSJ1 TRRAP INTS8 DDX1 DHX30 NIFK NWD2 HNRNPUL2 NAT10 SEC61A1 NIPBL

2.26e-0510821521638697112
Pubmed

Myocardium-Specific Deletion of Rac1 Causes Ventricular Noncompaction and Outflow Tract Defects.

HAND1 RAC1 HAND2

2.27e-0513152333804107
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

TCF20 SMCHD1 GSE1 ATXN1 MDC1 RERE NIPBL KNL1

2.52e-05268152833640491
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

ABCF1 IARS1 PARK7 DICER1 DHX30 NIFK GSE1 DCAF10 HNRNPUL2 NAT10 RERE DCAF7

3.34e-056551521235819319
Pubmed

TRIM65 regulates microRNA activity by ubiquitination of TNRC6.

MYO9B DNAJC21 EDC4 TRRAP DICER1 NIFK DCAF10 HNRNPUL2 DCAF7

3.44e-05364152924778252
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

TRAF5 C11orf54 CXCL10 FSD2 RALGAPA2 RBM20 NME8 SEC61A2 HNRNPUL2 PHACTR4 PKD1 SHOC1

5.21e-056861521229987050
Pubmed

Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation.

HAND1 RAC1 HAND2

5.32e-0517152311923206
Pubmed

A Pkd1-Fbn1 genetic interaction implicates TGF-β signaling in the pathogenesis of vascular complications in autosomal dominant polycystic kidney disease.

FBN1 PKD1

5.68e-053152224071006
Pubmed

Compromized geranylgeranylation of RhoA and Rac1 in mevalonate kinase deficiency.

MVK RAC1

5.68e-053152220814828
Pubmed

Isoform-specific membrane targeting mechanism of Rac during Fc gamma R-mediated phagocytosis: positive charge-dependent and independent targeting mechanism of Rac to the phagosome.

RAC1 RAC3

5.68e-053152216081809
Pubmed

Signaling and cytoskeletal requirements in erythroblast enucleation.

RAC1 RAC3

5.68e-053152222461493
Pubmed

Recruitment kinetics of DNA repair proteins Mdc1 and Rad52 but not 53BP1 depend on damage complexity.

MDC1 TP53BP1

5.68e-053152222860035
Pubmed

The chromatoid body of male germ cells: similarity with processing bodies and presence of Dicer and microRNA pathway components.

DICER1 DDX4

5.68e-053152216477042
Pubmed

Novel role of Rac-Mid1 signaling in medial cerebellar development.

RAC1 RAC3

5.68e-053152228512198
Pubmed

Localisation of Nup153 and SENP1 to nuclear pore complexes is required for 53BP1-mediated DNA double-strand break repair.

SENP1 TP53BP1

5.68e-053152228576968
Pubmed

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.

MDC1 TP53BP1

5.68e-053152224324146
Pubmed

rac, a novel ras-related family of proteins that are botulinum toxin substrates.

RAC1 RAC3

5.68e-05315222674130
Pubmed

Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks.

MDC1 TP53BP1

5.68e-053152230668775
Pubmed

Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development.

RAC1 RAC3

5.68e-053152222123845
Pubmed

The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18.

RAC1 RAC3

5.68e-053152216982419
Pubmed

Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G(2)/M checkpoint arrest.

MDC1 TP53BP1

5.68e-053152220421415
Pubmed

MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis.

DICER1 DDX4

5.68e-053152218320056
Pubmed

NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway.

MDC1 TP53BP1

5.68e-053152219001859
Pubmed

Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades.

TAOK2 TAOK1

5.68e-05315229786855
Pubmed

Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding.

HAND1 HAND2

5.68e-053152212070084
Pubmed

Mutations in the TP53 gene affected recruitment of 53BP1 protein to DNA lesions, but level of 53BP1 was stable after γ-irradiation that depleted MDC1 protein in specific TP53 mutants.

MDC1 TP53BP1

5.68e-053152228397142
Pubmed

TAO kinases mediate activation of p38 in response to DNA damage.

TAOK2 TAOK1

5.68e-053152217396146
GeneFamilyMyosins, class IX

MYO9A MYO9B

3.21e-05210321103
GeneFamilyRAB like GTPases

RABL2B RABL2A

3.18e-0451032394
GeneFamilyTransglutaminases

TGM6 TGM1

1.13e-0391032773
CoexpressionGSE21380_NON_TFH_VS_GERMINAL_CENTER_TFH_CD4_TCELL_DN

DCTN5 DOCK8 IARS1 SMCHD1 VWA5A MDC1 MARF1 TAOK1 UTRN DDX4

2.63e-0720015110M7505
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

DOCK8 MYO9B RALGAPA2 BIRC6 CEP350 PHACTR4 TAOK1 UTRN ARAP2

1.06e-061801519M8239
CoexpressionGSE369_PRE_VS_POST_IL6_INJECTION_IFNG_WT_LIVER_DN

MYO9A SMCHD1 HEATR5A PIKFYVE MTAP HNRNPUL2 MDC1 TAOK1 SSH2

2.54e-062001519M5980
CoexpressionGSE46606_UNSTIM_VS_CD40L_IL2_IL5_3DAY_STIMULATED_IRF4MID_SORTED_BCELL_DN

TRAF5 ZNFX1 INTS8 DDX1 ATXN1 ZFYVE26 GABPB1 ARAP2 KNL1

2.54e-062001519M9837
CoexpressionGRYDER_PAX3FOXO1_ENHANCERS_IN_TADS

MON2 DLG5 TCF20 ANK2 ACTR3C MYO9A MYO9B PARK7 DICER1 RBM20 DDX1 BABAM1 GSE1 ATXN1 NAT10 UBR3 ASTN2 RERE SSH2

5.86e-06100915119M157
CoexpressionGSE369_IFNG_KO_VS_WT_LIVER_UP

MON2 DNAJC21 PLEKHG5 GSE1 PHACTR4 MARF1 SSH2 NIPBL

2.11e-051991518M5970
CoexpressionGSE14350_TREG_VS_TEFF_UP

MON2 FAM234A DOCK8 SYNE1 ZNFX1 LCLAT1 VWA5A SSH2

2.11e-051991518M3417
CoexpressionGSE45739_UNSTIM_VS_ACD3_ACD28_STIM_NRAS_KO_CD4_TCELL_DN

DLG5 CBLB SLC1A7 NME8 PLAAT3 GSE1 SEMA4A DNMBP

2.11e-051991518M9885
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

MON2 SMCHD1 CBLB BIRC6 TAOK1 ANKRD36 UTRN NIPBL TP53BP1 ARAP2

1.02e-0918815210ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FNBP1 MYO9B BIRC6 NBPF19 ATXN1 RERE SSH2 UTRN

3.43e-071931528779276e775cb2492e8dd36436295a536084a6415
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

SYNE1 SMCHD1 CBLB ATXN1 ANKRD36 UTRN ARAP2

2.06e-0617115272e9a20f8980b78325c52065a9c14ab3656267c05
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRAF5 ADAMTSL1 BEND4 CCDC168 TMEM200A NBPF19 UTRN

2.31e-061741527ae363ce736fc8af439f3ad594d7bc2e344db80d4
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRAF5 ADAMTSL1 BEND4 CCDC168 TMEM200A NBPF19 UTRN

2.50e-06176152740993c41c1017b53039a337174fc56632b278609
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

CXCL10 SMCHD1 ZNFX1 CEP350 PHACTR4 TAOK1 UTRN

3.23e-0618315278f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

MON2 DOCK8 SMCHD1 CBLB BIRC6 TMEM200A POLQ

3.47e-061851527a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

MON2 DOCK8 SMCHD1 CBLB BIRC6 TMEM200A POLQ

3.60e-0618615278571956890fc9894d766ba294a28e376b4aba428
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYNE1 SMCHD1 CBLB ANKRD36 SSH2 UTRN ARAP2

4.14e-061901527d153a0bdedcd6865e6ee19575234a78b5d859ff1
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

HEATR5A BIRC6 CEP350 DCAF10 TAOK1 UTRN DCAF7

4.59e-061931527abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellmild-low-quality_cells|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DLG5 CTC1 SYNE1 CBLB ANKRD36 UTRN ARAP2

5.25e-061971527e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MON2 SYNE1 SMCHD1 CBLB ANKRD36 UTRN ARAP2

5.61e-061991527f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

MON2 BIRC6 ATXN1 UBR3 RERE SSH2 UTRN

5.61e-06199152794b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DOCK8 SMCHD1 BIRC6 CEP350 UTRN NIPBL ARAP2

5.79e-06200152712f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellAdult-Mesenchymal-myofibroblast_cell-D122|Adult / Lineage, Cell type, age group and donor

CFH RFTN2 TMEM200A FAM180A BMPER POLQ

1.73e-051581526410fa08c9d880d27e80ec939fa5ba5a41dcb31ab
ToppCellChildren_(3_yrs)-Mesenchymal-chondrocyte-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CFH FAT3 IGDCC3 RFTN2 FBN1 BMPER

1.73e-051581526e5636c0b608d68bd426a2b446ac508e4512e86a4
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma|TCGA-Brain / Sample_Type by Project: Shred V9

DOCK8 ASAP3 HEATR5A CACHD1 ECH1 GAREM1

2.00e-051621526810881210e015c788814e4fe8d7a24c929cf2621
ToppCellAdult-Mesenchymal-myofibroblast_cell|Adult / Lineage, Cell type, age group and donor

CFH RFTN2 FBN1 BMPER POLQ JAM3

2.37e-051671526d584a8548a5317bd9686b3be8246ae6ed568796b
ToppCellfacs|World / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH TRAF5 DCTN5 BIRC6 MARF1 SEC61A1

2.80e-051721526a2d0a64ebf09d219a07d6bbad1056bad6d46b9be
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRAF5 ADAMTSL1 BEND4 CCDC168 TMEM200A NBPF19

2.89e-0517315268ac2e9d39c0f76e674f8bd59d1da246bab4867c8
ToppCell5'-Adult-Appendix-Hematopoietic-T_cells-CX3CR1+_CD8_Tmem|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SYNE1 SMCHD1 CBLB NME8 UTRN ARAP2

3.18e-0517615266b06da40eb97ea2db09f3a769494738b3e5fe3fa
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRAF5 ADAMTSL1 BEND4 CCDC168 TMEM200A NBPF19

3.28e-051771526f902600c639087664316b3cf30cab243bc3d1c5c
ToppCellfacs-Marrow-T-cells-3m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL1 FAT3 PLEKHG5 SEMA4A ALOX5 HAND2

3.39e-05178152641745a589567ca5ea6d06331f4c8da03595b5f5c
ToppCellfacs-Marrow-T-cells-3m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL1 FAT3 PLEKHG5 SEMA4A ALOX5 HAND2

3.39e-051781526eb940dd64c973f68bcaad6069d3bd56383329db5
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

C11orf54 TRRAP TFE3 PDE12 HNRNPUL2 TAOK1

3.95e-051831526807d64deaf4e50dccf6f831f88578a6d903c1421
ToppCellMild/Remission-B_intermediate-10|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ANK2 MYO9B CBLB PIKFYVE ATXN1 DNMBP

3.95e-051831526278064c9f0582463b83bf156d34e77f60187613b
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK8 SMCHD1 BIRC6 CEP350 UTRN NIPBL

4.08e-0518415261154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellControl-Neu_4|World / 5 Neutrophil clusters in COVID-19 patients

KLHL6 DNAH10 DCLRE1B UBR3 UTRN KNL1

4.08e-051841526ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

C11orf54 TRRAP TFE3 PDE12 HNRNPUL2 TAOK1

4.33e-05186152676cbc3610aedf8c19c17ad5faf6ef5e8980b6af5
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ADAMTSL1 FBN1 FAM180A BMPER HAND2

4.46e-0518715264e553721fa5598cb211f44e3226280b7e6885484
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ADAMTSL1 FBN1 FAM180A BMPER HAND2

4.46e-051871526d36e7fc6125e7a4310499365022d38f34b757a73
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ADAMTSL1 FBN1 FAM180A BMPER HAND2

4.46e-051871526827eae63fabf6892a82ce7779b5f395958d3d628
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 SYNE1 CBLB FBN1 SEMA4A JAM3

4.87e-0519015261121eb607a984c59fbffe7220837fc178745aa55
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 SYNE1 CBLB FBN1 SEMA4A JAM3

4.87e-051901526048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCellcontrol-Myeloid-Mast_cell|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SLC12A8 TRIM68 SENP1 VWA5A ZFYVE26 CYB5R1

5.02e-051911526afebdc59a1f884ce3f2f5fe040e16b0e95e4e7c5
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CTC1 SYNE1 SMCHD1 ANKRD36 UTRN ARAP2

5.32e-0519315269337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-parabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL1 DOCK8 RBM20 PLAAT3 TGM1 MVK

5.32e-05193152655eab7d2574e9cc2ed8f08e0a7ca7cbf90fb5818
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_T_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SYNE1 CBLB PLAAT3 ATXN1 UTRN ARAP2

5.32e-051931526a594f89a18273797506287d9e22f72abe53e4920
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL6 FNBP1 DOCK8 TRPM2 ADA2 ALOX5

5.63e-0519515267b6c69df943842b566a596e30bb50dbe80dccc83
ToppCellmoderate-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

KLHL6 DNAH10 SYNE1 RABL2B RABL2A TTLL10

5.63e-0519515263486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell10x5'v1-week_17-19-Mesenchymal_osteo-stroma-osteoblast_precursor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

CFH ADAMTSL1 PCDHGA7 GPR37 IGDCC3 TPBG

5.79e-05196152657df2a57b35be9851ac0b1e5731baa53052511f0
ToppCellMild-CD8+_T_activated|World / Disease group and Cell class

SMCHD1 ZNFX1 ADA2 TAOK1 UTRN ARAP2

5.79e-05196152679632190e44fcef9d7c11d9b9e37f2ebf0e6e255
ToppCellNS-control-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KLHL6 DNAH10 SYNE1 RABL2B RABL2A TTLL10

5.79e-051961526d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCellcontrol-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

KLHL6 DNAH10 SYNE1 RABL2B RABL2A TTLL10

5.96e-051971526e453d085182364ca347cbcc9dc995c62c3353016
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 SYNE1 CBLB FBN1 SEMA4A UTRN

5.96e-0519715269b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCellBronchial-NucSeq-Stromal-Peri/Epineurial_|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CFH ANK2 BEND4 CBLB TGM1 JAM3

5.96e-051971526ee8f7def9d5af7b1e636830a4ea1da158d02f25a
ToppCellcontrol-Epithelial-Ciliated|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

KLHL6 DNAH10 SYNE1 RABL2B RABL2A TTLL10

5.96e-051971526d4e963c1f82996371bf3d63578ee9fce8e00c5a8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL6 FNBP1 DOCK8 TRPM2 ADA2 ALOX5

5.96e-05197152661ef3f417767c3f5296a26399da63e3e4f58faf8
ToppCellImmune|World / Lineage, Cell type, age group and donor

KLHL6 FNBP1 DOCK8 MYO9B ADA2 ALOX5

6.13e-05198152665681b54d13c6997bd90a1c2a12314a80e964fe3
ToppCellbackground-Hepatic_Stellate_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

CFH ADAMTSL1 FAT3 FBN1 FAM180A HAND2

6.13e-05198152679f32f965aed6a10c5cb803173e3db7b32e07a91
ToppCelldistal-1-mesenchymal-Mesothelial|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CFH SLC12A8 TMEM200A TGM1 HAND2 TPBG

6.30e-0519915268dd5b411d2f1626830b77a1616cc3fb67dc59338
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL6 DOCK8 MYO9B TRPM2 ADA2 ALOX5

6.30e-05199152604adf46975aa4194ea40c7480f8a517def5d929c
ToppCellsevere-B_intermediate|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ANK2 BEND4 PIKFYVE DUS2 JAM3 VEGFB

6.30e-05199152617283d75a2a900369f63ed02996e7ede97f46140
ToppCellBronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFH ADAMTSL1 GRK4 ASAP3 SETD4 JAM3

6.30e-051991526a13f4b8a039304e685464cc8879659824cad5a3e
ToppCellmild-MAIT|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CFH SYNE1 CBLB UTRN ARAP2 TPBG

6.30e-051991526cbe1fb6d2c5fca7a1baf1ad20afcdf8e8e11bd84
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

RALGAPA2 BIRC6 PLEKHG5 TAOK2 UTRN NIPBL

6.48e-052001526dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellmild-NK_CD56bright|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TRAF5 CBLB MDC1 TTLL10 UTRN ARAP2

6.48e-052001526a195bc6784346f706d4cd5b740adac1d950ce88a
ToppCellTracheal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CFH ANK2 SYNE1 RFTN2 FBN1 BMPER

6.48e-052001526c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_GZMK+|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FNBP1 DOCK8 SMCHD1 CBLB RBM20 TRBV14

6.48e-052001526510d84bf7a4621b079e5a7330d25e04508c84a49
ToppCell3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

SYNE1 SMCHD1 ANKRD36 UTRN ARAP2

1.00e-041351525ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCellE16.5-Immune-Immune_Myeloid-Granulocytic|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KLHL6 FAT3 SEMA4A DNMBP ALOX5

1.92e-041551525c648512305166d2a2f0e284c127bc802af908071
ToppCellmild-Myeloid-Eosinophils|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

REXO5 MYO9B SYNE1 HEATR5A SSH2

2.42e-0416315257c57d541a88e9afa079e95b8a6ecdea60a0c6aaa
ToppCellsevere-unassigned|severe / disease stage, cell group and cell class

EOGT SETD4 NME8 MINDY4 DNMBP

2.56e-041651525f9ddd547992fec065d539a1d0305acba8fc7d79c
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CFH ADAMTSL1 RBM20 VWA5A UTRN

2.70e-041671525a6ff7a3d9b80839c0efa91658836812e868561fa
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Col15a1_(Col15a1)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ABCA4 DNAH10 CXCL10 FAM180A

2.78e-04921524d2c1d25e5bb6ba4f406e916e3c0a5ad05492e59d
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Col15a1_(Col15a1)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ABCA4 DNAH10 CXCL10 FAM180A

2.78e-04921524926e02725a03d8473eda25d4aef63e34a6566224
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

UNC13B ADAMTSL1 RBM20 BMPER SEMA4A

2.78e-0416815257abaddbcc55e44653d54aa15464266aa6bd5c9d2
ToppCellBasal_cells-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

GRK4 BMPER JAM3 ARAP2 TPBG

2.94e-041701525776d4224a682b6c648041827efd69794f88906f0
ToppCellCOVID-19_Moderate-NK_CD56bright|World / disease group, cell group and cell class

TRAF5 CBLB MDC1 TTLL10 ARAP2

2.94e-041701525caa6a534c1e9639caced9a51680f5c905f061bcc
ToppCellfacs|World / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRAF5 TCF20 BIRC6 MARF1 SEC61A1

3.02e-041711525c9990bc041a632b2f7bbebbfe737772c423d7027
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOCK8 ARRDC4 FAT3 SLC1A7 ALOX5

3.10e-041721525c8ea80042faf923b08ff03d73100533d521d73ef
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL6 DOCK8 TRPM2 ADA2 ALOX5

3.10e-041721525f6b4754a7e4b3e38030316a0ae00d932bfa87e41
ToppCellBronchial_Brush-Epithelial-Ionocytes|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

ANK2 FAT3 TRPM2 DDX4 JAM3

3.18e-041731525e1de849dcd96063136bdac87e050ddbd55cabdcc
ToppCellfacs-Lung-Endomucin-24m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCL10 ASAP3 TMEM200A FBN1 GAREM1

3.18e-041731525a37f38478473290fe35aea8684befc3bf95b161f
ToppCellBronchial_Brush-Epithelial-Ionocytes|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

ANK2 FAT3 TRPM2 DDX4 JAM3

3.18e-041731525f2a8f4918c1fb68d98bc3f33cd624de0f0f11e06
ToppCellE16.5-Immune-Immune_Myeloid-Granulocytic-Basophil|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KLHL6 FAT3 SEMA4A DNMBP ALOX5

3.18e-0417315252cba41c3d9d3076f703115d19729073a3ac3feb6
ToppCellE16.5-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KLHL6 FAT3 SEMA4A DNMBP ALOX5

3.18e-04173152511d69a4ab4a87b8820cd3bd204de8c4124450a90
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_TBCC|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTSL1 RBM20 VWA5A SEMA4A UTRN

3.27e-041741525912a9e892b29d945666fc37c986009c97c668ac8
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOCK8 MYO9B ADA2 ZFYVE26 ALOX5

3.27e-041741525d5c22b43531414951666ee7542a66ed9380e2d14
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTSL1 RBM20 VWA5A BMPER SEMA4A

3.27e-041741525e4d65fe121a32ac4cdd6312e7b8f867f0852e991
ToppCell5'-Adult-LargeIntestine-Mesenchymal-stromal_related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH HEATR4 ASAP3 RFTN2 HAND2

3.35e-041751525b8995e7ada85ba959f06264a0295b61e390c4e6c
ToppCellCOVID-19_Severe-Classical_Monocyte-cMono_1|Classical_Monocyte / Disease condition and Cell class

FAM234A ADAMTSL1 ADA2 PLEKHG5 MARF1

3.35e-04175152535ea2ed93538e6bf803029fcf7d9243f93e7733d
ToppCellfacs|World / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRAF5 TCF20 BIRC6 MARF1 SEC61A1

3.35e-04175152553e96956019f984decc1c81376ebc88fbf3c4d40
ToppCell5'-Adult-LargeIntestine-Mesenchymal-stromal_related-T_reticular|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH HEATR4 ASAP3 RFTN2 HAND2

3.35e-0417515257ae76bd3b4f610b2f98716a4456437cd3696b686
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA4 BEND4 LCLAT1 TGM1 FBN1

3.44e-0417615253766e0533b103ec92ac75eba3df02e287efc53fa
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA4 BEND4 LCLAT1 TGM1 FBN1

3.44e-041761525aa1bada2175d8370fc71939a607407155259d195
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTSL1 BEND4 RBM20 VWA5A UTRN

3.44e-041761525ed421d8525108d2f585265d2cf777f07b29f44f0
ToppCellNS-moderate-d_07-13-Epithelial-Ionocyte|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ANK2 ACTR3C FAT3 DDX4 JAM3

3.53e-04177152599500aed584f793aaf308f8afbf5d1c6a9b4ee55
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-Mast_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

REXO5 MYO9B NME8 VWA5A ALOX5

3.53e-0417715254a222234ca6cf28a34205c4bd675cd49d92b5b2e
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6|TCGA-Ovary / Sample_Type by Project: Shred V9

ADAMTSL1 SYNE1 TMEM200A FBN1 HAND2

3.63e-041781525142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCL10 SYNE1 SMCHD1 UTRN ARAP2

3.63e-04178152501dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellT_cells-ISG-high_CD4+_T_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

CXCL10 SMCHD1 ZNFX1 TGM1 DHRS2

3.72e-041791525af35ef8a7768cee0c2af0590e5bec35cee6a4714
ToppCell367C-Lymphocytic-ILC-ILC-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

DCLRE1B PLEKHG5 PKD1 ANKRD36 ARAP2

3.72e-0417915255aa8465e943b6b666c7f8b1937fcc3764bfe91f6
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TPGS1 ZNFX1 DUS2 FBN1 MINDY4

3.72e-041791525ce3ca7f3a5864e62307aa744a3173f350a90df28
ToppCell3'-GW_trimst-1-LargeIntestine-Hematopoietic-Myeloid-CLC+_Mast_cell|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

REXO5 DOCK8 VWA5A TTLL10 ALOX5

3.82e-0418015251c5515f29ead129bee3b4ca27799796956811a39
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CFH ADAMTSL1 RBM20 GSE1 SEMA4A

3.82e-041801525e8841ef1239f9ee73ac4f4e11faca0742694f368
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DLG5 PARK7 FAM180A PKD1 SEC61A1

3.82e-041801525e4add4c94f892a2d93926e5c6dac6a738319d091
ToppCellfacs-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ADAMTSL1 FBN1 BMPER HAND2

3.91e-041811525269b39ac65790061d54eab47a8eeb024403f0348
ToppCellPCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_B-im_B_cell_(15)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

KLHL6 DOCK8 BEND4 ALOX5 ARAP2

3.91e-04181152551e4d6bfdbf414d8e30aee2e6f7492f4f7f54373
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ABCA4 IGDCC3 NWD2 BMPER TPBG

3.91e-0418115256e8c5460021d3999daec58e3d6661a6fa998fd16
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

SYNE1 SMCHD1 CBLB CEP350 UTRN

5.83e-0549925GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_CHROMATIN
DrugAmiloride hydrochloride dihydrate [17440-83-4]; Down 200; 13.2uM; MCF7; HT_HG-U133A

FNBP1 CTC1 SEC61A2 MTAP ASTN2 SEMA4A DHRS2 MVK RAC3 VEGFB

7.66e-07197150101470_DN
DrugNafronyl oxalate [3200-06-4]; Down 200; 8.4uM; HL60; HT_HG-U133A

ANK2 MYO9B TRIM68 ADA2 HNRNPUL2 MVK TP53BP1 GABPB1 DCAF7

6.05e-0619515091267_DN
Diseasecytochrome c oxidase assembly factor 3 homolog, mitochondrial measurement

CFH CXCL10 PIKFYVE

6.00e-0681423EFO_0801513
Diseasecytochrome c oxidase subunit 4 isoform 2, mitochondrial measurement

CFH CXCL10 PIKFYVE

8.97e-0691423EFO_0801514
DiseaseRNA-binding protein 24 measurement

CFH CXCL10 PIKFYVE

8.97e-0691423EFO_0802030
DiseaseDNA-directed RNA polymerases I and III subunit RPAC1 measurement

CFH CXCL10 PIKFYVE

1.28e-05101423EFO_0801535
Diseaseguanylate-binding protein 6 measurement

CFH CXCL10 PIKFYVE

1.75e-05111423EFO_0801662
DiseaseDevelopmental delay (disorder)

TCF20 SPTBN2 TAOK1 RAC1

3.00e-05371424C0424605
Diseasetype 1 diabetes mellitus (implicated_via_orthology)

DOCK8 CXCL10 CBLB SENP1

3.71e-05391424DOID:9744 (implicated_via_orthology)
Diseaseautosomal dominant intellectual developmental disorder 48 (implicated_via_orthology)

RAC1 RAC3

6.88e-0531422DOID:0080235 (implicated_via_orthology)
Diseaseprotein YIPF6 measurement

CFH PIKFYVE

6.88e-0531422EFO_0802969
Diseasegranzyme M measurement

CFH TPGS1

6.88e-0531422EFO_0801655
DiseaseTourette syndrome, schizophrenia

TCF20 DNAH10 RERE

8.44e-05181423EFO_0004895, MONDO_0005090
Diseasebeta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 measurement

CFH CXCL10

1.37e-0441422EFO_0801407
DiseaseE3 ubiquitin-protein ligase RNF149 measurement

CFH PIKFYVE

1.37e-0441422EFO_0802511
Diseaserap guanine nucleotide exchange factor 5 measurement

CFH PIKFYVE

1.37e-0441422EFO_0802989
DiseaseColorectal Carcinoma

UNC13B ABCA4 ANK2 SYNE1 SPTBN2 ASAP3 SETD4 SLC1A7 GSE1 DHRS2 TTLL10 GABPB1

1.56e-0470214212C0009402
Diseasezinc transporter 3 measurement

CFH PIKFYVE

2.28e-0451422EFO_0803287
Diseaseprenatal alcohol exposure

HAND1 HAND2

2.28e-0451422C0678807
Diseasetoll-like receptor 1 measurement

CFH PIKFYVE

2.28e-0451422EFO_0803159
Diseasetachykinin-4 measurement

CFH PIKFYVE

2.28e-0451422EFO_0803137
Diseaseserine/threonine-protein kinase Chk1 measurement

CFH PIKFYVE

2.28e-0451422EFO_0021965
Diseasemembrane-associated progesterone receptor component 2 measurement

CFH PIKFYVE

2.28e-0451422EFO_0801796
Diseaseinsulin-like growth factor I measurement

CFH CXCL10

2.28e-0451422EFO_0801702
DiseaseERO1-like protein alpha measurement

CFH CXCL10

3.41e-0461422EFO_0801582
Diseasepre-mRNA-processing factor 6 measurement

CFH PIKFYVE

3.41e-0461422EFO_0802894
DiseaseE3 ubiquitin-protein ligase RNF128 measurement

CFH PIKFYVE

3.41e-0461422EFO_0801555
Diseaseo-acetyl-ADP-ribose deacetylase MACROD1 measurement

CFH PIKFYVE

3.41e-0461422EFO_0802827
Diseasecytosolic non-specific dipeptidase measurement

CFH CXCL10

3.41e-0461422EFO_0020310
Diseasecyclin-dependent kinase 8:cyclin-c complex measurement

CFH CXCL10

3.41e-0461422EFO_0020297
Diseasethioredoxin-interacting protein measurement

CFH PIKFYVE

3.41e-0461422EFO_0803149
Diseasealpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 measurement

CFH CXCL10

3.41e-0461422EFO_0801372
Diseaseribosome biogenesis protein TSR3 homolog measurement

CFH PIKFYVE

3.41e-0461422EFO_0803025
Diseaseleucine-rich repeat and fibronectin type III domain-containing protein 1 measurement

CFH PIKFYVE

3.41e-0461422EFO_0802689
DiseaseDNA-binding protein SATB2 measurement

CFH PIKFYVE

3.41e-0461422EFO_0802484
Diseaseserine/threonine-protein kinase PAK 3 measurement

CFH CXCL10

3.41e-0461422EFO_0020728
Diseasereceptor-type tyrosine-protein kinase flt3 measurement

CFH CXCL10

3.41e-0461422EFO_0020703
Diseasethymidine kinase, cytosolic measurement

CFH PIKFYVE

3.41e-0461422EFO_0020773
Diseaserab9 effector protein with kelch motifs measurement

CFH PIKFYVE

3.41e-0461422EFO_0801984
Diseaseprotocadherin beta-4 measurement

CFH CXCL10

3.41e-0461422EFO_0801976
Diseasezinc finger protein 276 measurement

CFH CXCL10

3.41e-0461422EFO_0802227
Diseasephosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform measurement

CFH CXCL10

3.41e-0461422EFO_0020637
Diseasethiosulfate sulfurtransferase measurement

CFH SLC1A7

3.41e-0461422EFO_0802130
DiseaseCCAAT/enhancer-binding protein beta measurement

CFH PIKFYVE

3.41e-0461422EFO_0021905
Diseaseleucine-rich repeat-containing protein 74A measurement

CFH PIKFYVE

3.41e-0461422EFO_0801763
Diseasesecreted frizzled-related protein 2 measurement

CFH PIKFYVE

3.41e-0461422EFO_0802039
DiseaseGlobal developmental delay

TCF20 SPTBN2 TRRAP TAOK1 RAC1

4.72e-041331425C0557874
Diseaseectonucleoside triphosphate diphosphohydrolase 3 measurement

CFH CXCL10

4.75e-0471422EFO_0020343
Diseasemyotubularin-related protein 1 measurement

CFH PIKFYVE

4.75e-0471422EFO_0802773
DiseaseBCL-2-like protein 1 measurement

CFH CXCL10

4.75e-0471422EFO_0020177
Diseasetoll-like receptor 4:Lymphocyte antigen 96 complex measurement

CFH ASTN2

4.75e-0471422EFO_0008301
Diseaseregulator of G-protein signaling 8 measurement

CFH CXCL10

4.75e-0471422EFO_0801997
Diseasephosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha measurement

CFH CXCL10

4.75e-0471422EFO_0801881
Diseaseuroplakin-3b-like protein measurement

CFH CXCL10

4.75e-0471422EFO_0802204
Diseasekv channel-interacting protein 1 measurement

CFH PIKFYVE

4.75e-0471422EFO_0801751
Diseasekinesin-like protein KIF16B measurement

CFH CXCL10

4.75e-0471422EFO_0801747
Diseasemacrophage-stimulating protein receptor measurement

CFH CXCL10

4.75e-0471422EFO_0020550
DiseaseRNA polymerase II elongation factor ELL measurement

CFH PIKFYVE

4.75e-0471422EFO_0802028
DiseaseSpinocerebellar Ataxia Type 2

SPTBN2 TGM6 ATXN1

5.85e-04341423C0752121
DiseaseSpinocerebellar Ataxia Type 1

SPTBN2 TGM6 ATXN1

5.85e-04341423C0752120
DiseaseSpinocerebellar Ataxia Type 5

SPTBN2 TGM6 ATXN1

5.85e-04341423C0752123
DiseaseSpinocerebellar Ataxia Type 7

SPTBN2 TGM6 ATXN1

5.85e-04341423C0752125
DiseaseSpinocerebellar Ataxia Type 6 (disorder)

SPTBN2 TGM6 ATXN1

5.85e-04341423C0752124
DiseaseAtaxia, Spinocerebellar

SPTBN2 TGM6 ATXN1

5.85e-04341423C0087012
Diseasedesmoglein-1 measurement

CFH CXCL10

6.32e-0481422EFO_0020321
Diseasealpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 measurement

CFH CXCL10

6.32e-0481422EFO_0801373
Diseasechromobox protein homolog 5 measurement

CFH CXCL10

6.32e-0481422EFO_0020258
Diseasetumor necrosis factor receptor superfamily member 19L measurement

CFH PIKFYVE

6.32e-0481422EFO_0008309
Diseasetumor necrosis factor receptor superfamily member 3 measurement

CFH CXCL10

6.32e-0481422EFO_0020813
Diseasestabilin-2 measurement

CFH CXCL10

6.32e-0481422EFO_0020752
Diseasezinc-alpha-2-glycoprotein measurement

CFH CXCL10

6.32e-0481422EFO_0802228
Diseaseopioid-binding protein/cell adhesion molecule measurement

CFH CXCL10

6.32e-0481422EFO_0020618
Diseasekallikrein-6 measurement

CFH CXCL10

6.32e-0481422EFO_0801739
Diseasegrowth factor receptor-bound protein 7 measurement

CFH PIKFYVE

6.32e-0481422EFO_0801659
DiseaseSpinocerebellar Ataxia Type 4

SPTBN2 TGM6 ATXN1

6.38e-04351423C0752122
Diseasecomplement C1q and tumor necrosis factor-related protein 9A measurement

CFH CXCL10

8.10e-0491422EFO_0803293
Diseaseepididymal-specific lipocalin-10 measurement

CFH CXCL10

8.10e-0491422EFO_0801576
Diseasedickkopf-like protein 1 measurement

CFH CXCL10

8.10e-0491422EFO_0020324
Diseaseectonucleoside triphosphate diphosphohydrolase 1 measurement

CFH CXCL10

8.10e-0491422EFO_0020342
Diseasecyclin-dependent kinase 5:cyclin-dependent kinase 5 activator 1 complex measurement

CFH CXCL10

8.10e-0491422EFO_0020296
Diseasecellular retinoic acid-binding protein 1 measurement

CFH CXCL10

8.10e-0491422EFO_0801463
Diseaseapolipoprotein D measurement

CFH CXCL10

8.10e-0491422EFO_0020156
Diseaseoxysterols receptor LXR-beta measurement

CFH CXCL10

8.10e-0491422EFO_0801865
Diseasecomplement component C8 measurement

CFH CXCL10

8.10e-0491422EFO_0008094
Diseasemast cell-expressed membrane protein 1 measurement

CFH CXCL10

8.10e-0491422EFO_0801787
Diseaseinterleukin-34 measurement

CFH CXCL10

8.10e-0491422EFO_0020505
Diseasekallikrein-14 measurement

CFH CXCL10

8.10e-0491422EFO_0020513
Diseaseleucine-rich repeat serine/threonine-protein kinase 2 measurement

CFH CXCL10

8.10e-0491422EFO_0021876
Diseaseheterogeneous nuclear ribonucleoprotein q measurement

CFH CXCL10

8.10e-0491422EFO_0020443
Diseasevital capacity

CFH ADAMTSL1 TCF20 SYNE1 SPTBN2 RBM20 SENP1 ASTN2 BMPER UTRN NLRP4 MVK GABPB1 RAC3 DCAF7

9.34e-04123614215EFO_0004312
DiseaseDNA repair protein rad51 homolog 1 measurement

CFH CXCL10

1.01e-03101422EFO_0020330
DiseaseSecreted frizzled-related protein 3 measurement

CFH CXCL10

1.01e-03101422EFO_0008277
Diseaseserine/threonine-protein kinase 16 measurement

CFH CXCL10

1.01e-03101422EFO_0020724
Diseasetranscription factor IIIb 90 kda subunit measurement

CFH PIKFYVE

1.01e-03101422EFO_0020778
Diseaseceliac disease (is_implicated_in)

MYO9B F2

1.01e-03101422DOID:10608 (is_implicated_in)
Diseasetropomyosin beta chain measurement

CFH CXCL10

1.01e-03101422EFO_0020787
DiseaseOCIA domain-containing protein 1 measurement

CFH PIKFYVE

1.01e-03101422EFO_0008252
Diseasedecadienedioic acid (C10:2-DC) measurement

SLC17A3 HEATR4

1.01e-03101422EFO_0800598
Diseaseinterleukin-37 measurement

CFH CXCL10

1.01e-03101422EFO_0020506
Diseaseinsulin growth factor-like family member 3 measurement

CFH CXCL10

1.01e-03101422EFO_0801700
Diseasecytochrome p450 3a4 measurement

CFH PIKFYVE

1.23e-03111422EFO_0020303
Diseasetumor necrosis factor receptor superfamily member 11B measurement

CFH CXCL10

1.23e-03111422EFO_0020801

Protein segments in the cluster

PeptideGeneStartEntry
KSIVDNQCVLPPEIR

nan

351

A8MVM7
RPVAQDVALVECAVP

FAM234A

151

Q9H0X4
PIEDAKCDIVIEKPT

EOGT

221

Q5NDL2
IPPNIDVLLCEQEVV

ABCF1

356

Q8NE71
LTLLTCQVRPNPEEK

ASAP3

346

Q8TDY4
LEQIRNPSPCFKEVI

BIRC6

4741

Q9NR09
VKEPNVQLTPLVIDC

CTC1

31

Q2NKJ3
KELQEPECIIVAPTR

DDX4

361

Q9NQI0
PECIIVAPTRELVNQ

DDX4

366

Q9NQI0
VPEAKLVECIGQELI

ABCA4

1216

P78363
PIVICPVTQESEKEA

BTNL8

456

Q6UX41
PLVKVERVFCPEKAE

GSE1

621

Q14687
EELRRKLESIPVPCQ

BEND4

341

Q6ZU67
ILCIVVIQPEIPVKQ

CACHD1

601

Q5VU97
SVPVTCKIRVFPEID

DUS1L

141

Q6P1R4
DQTSPCPLVLVRIEE

DNMBP

686

Q6XZF7
RKEPDCSIIIRISPV

ARAP2

1336

Q8WZ64
KDVLPPVEEAVDRCL

ANKRD36

386

A6QL64
NDIPICEVVKCLPVT

CFH

136

P08603
PSLIPQEVKICIEGR

ATXN1

796

P54253
VDIPKCNLVVRFDLP

DICER1

526

Q9UPY3
CTIQVPEPILRKIET

DHX30

346

Q7L2E3
VAALKPCQVVPIVSR

DCLRE1B

286

Q9H816
EVVILDVRVPCTPVA

DCAF7

246

P61962
VIPLPVEEQCRGVLS

ASTN2

816

O75129
CVRAVLERPKVPDQS

ARRDC4

141

Q8NCT1
IVNFKLIPDCPDIIV

NWD2

1481

Q9ULI1
PISCVKEEIQETQTP

NIFK

266

Q9BYG3
EIVPIDQKDKICPET

RBM20

931

Q5T481
AEPFCPKTREVLIET

MTAP

141

Q13126
EVTCTIPENLPFKLE

PCDHGA7

381

Q9Y5G6
KTVFDEAIRAVLCPP

RAC3

166

P60763
KTVFDEAIRAVLCPP

RAC1

166

P63000
PRLVIEECPLTSEAQ

RFTN2

121

Q52LD8
RSIRDEIKKTVPPCV

EDC4

1041

Q6P2E9
PDIPLRQVIAEECVA

INTS8

651

Q75QN2
EFRPEIPCIVVANKI

RABL2A

121

Q9UBK7
EFRPEIPCIVVANKI

RABL2B

121

Q9UNT1
LPLFVKVRDTTQEPC

ANK2

1411

Q01484
QVDETLIPRKVPSLC

SLC17A3

21

O00476
FVETVEADPLIRQCP

KLHL6

271

Q8WZ60
RVLLCKDVENQLSPP

IGDCC3

666

Q8IVU1
RECDPAELEEKVPKV

MDC1

926

Q14676
VDEVIQNCPIDVRRP

ACTR3C

171

Q9C0K3
ISEEPPAKRQCIEII

GABPB1

321

Q06547
SVIPPCKSELRVLVV

LCLAT1

331

Q6UWP7
CRCEIKGTEPIIVDP

CBLB

411

Q13191
IIDNTEERLCLPPVE

FSIP2

4676

Q5CZC0
EERLCLPPVERDVVK

FSIP2

4681

Q5CZC0
ILADELCRQPKPSTV

ADAMTSL1

706

Q8N6G6
LNCTISQVEPDIKVP

DDX1

666

Q92499
KDPVQCSRDVVICPD

PARK7

41

Q99497
ERAVVRCVPSEPKLS

PDE12

36

Q6L8Q7
ELVDCLPKEASPLRV

DCAF10

506

Q5QP82
ETFNVIERCPKPVIA

ECH1

151

Q13011
VPPKSEAVREECRLL

GAREM1

516

Q9H706
RTAVPPKTIEECEVI

HNRNPUL2

441

Q1KMD3
ILRDICIEQPTFPKI

NIPBL

1871

Q6KC79
VVIPAQFLEEQKCVP

DLG5

1126

Q8TDM6
APCPLLEKEEVIQTS

KNL1

1386

Q8NG31
ELRECIPNVPADTKL

HAND1

116

O96004
PVCPKELRDQVTISE

NLRP4

281

Q96MN2
IELTVQVKPVTPVCR

JAM3

131

Q9BX67
KCPLPRQQVTEIIFV

MON2

1631

Q7Z3U7
PQENVSVTEIIKPCD

DNAJC21

431

Q5F1R6
EPCAEVPVLLKEQVD

RALGAPA2

526

Q2PPJ7
TSVIPKLPQCLREEE

PHACTR4

496

Q8IZ21
FPCLEEKVLETPQEI

NAT10

656

Q9H0A0
ELRECIPNVPADTKL

HAND2

121

P61296
ERVPIAVCEKEPSSI

PIKFYVE

1656

Q9Y2I7
RLQCINVETIPDLPE

ADAM30

556

Q9UKF2
PEVTTIPCLQKRCID

HEATR5A

1841

Q86XA9
AERCIIKISPDLPDT

GPR37

416

O15354
EVQIRTPRVNCPEKV

BABAM1

81

Q9NWV8
TPRVNCPEKVIICLD

BABAM1

86

Q9NWV8
CEECLLRVPPEDIKV

BMPER

286

Q8N8U9
LDVVFTPKECRTLQP

DOCK8

91

Q8NF50
LPCETKPVSLQEIVA

SLC1A7

491

O00341
EVDRQVIPIIGKCLD

FNBP1

236

Q96RU3
RPNPITVILEDIDEC

FBN1

1596

P35555
ECPPVILEQKELLEV

POLQ

376

O75417
EKLEIIPASQFCPRV

CXCL10

46

P02778
IEPVLGIITICKEPD

FAT3

1616

Q8TDW7
RPSEVCDTEAVIKPV

HEATR4

936

Q86WZ0
EPKRVTQQPCETLLA

CEP350

2901

Q5VT06
KDIPIEVCPISNQVL

ADA2

401

Q9NZK5
CKILDNTVLPPETVV

DCTN5

126

Q9BTE1
EVIDLLKSQPSCVIP

MARF1

1106

Q9Y4F3
TVCNNVIPKSIPDIR

FAM180A

91

Q6UWF9
SRLPQPAEVVVCLDE

HOMEZ

501

Q8IX15
PAEPIQREETKKCLQ

CCDC168

1871

Q8NDH2
PVTCKIRILPSLEDT

DUS2

151

Q9NX74
IPPDVVTECRLGLKE

GRK4

121

P32298
LELAPKDIRVNCVVP

DHRS2

201

Q13268
IECPPQKGEEEEVVI

DNAH10

941

Q8IVF4
APRILQCIAQEKVIP

SLC12A8

331

A0AV02
IEACTIRLPAPELKE

C18orf63

156

Q68DL7
CREPEVDVVLPLQVL

PKD1

2146

P98161
VEIREECGPLPIVVA

MRPS5

371

P82675
KEVEAELCRPLLVCP

STK11IP

531

Q8N1F8
REVPTTLKECIQEPS

UTRN

2176

P46939
ARIEIPSCKDVAPVE

SMCHD1

1011

A6NHR9
LEVIKPFCAVLPEIQ

SEC61A2

6

Q9H9S3
PLPCSKIIQRAEELV

PLAAT3

86

P53816
IEELCVKLPVRDPVR

SYNE1

1081

Q8NF91
PVIKLNNCVIDEPSI

TMEM200A

291

Q86VY9
IRRCTELPEKLPVTT

ALOX5

246

P09917
CPRLSRELVEVVEPE

NBPF19

1471

A0A087WUL8
TLPPQAVEFIVCRVK

TDRD12

991

Q587J7
PPIIKTKEIRSCEEA

FSD2

471

A1L4K1
KEVLAVPNSILELPC

SEMA4A

566

Q9H3S1
RVPLEKEIPVTVVQE

SENP1

391

Q9P0U3
VCLEPEVVNLLPKSL

SETD4

141

Q9NVD3
KINIGPEVVQRECVP

SHLD2

186

Q86V20
CQLQELLPEVPEKVL

SHOC1

1076

Q5VXU9
CLQKIPQDRPTSEEL

TAOK1

261

Q7L7X3
CLQKIPQDRPTSEVL

TAOK2

261

Q9UL54
IIRKDSLPVCPVDAS

IARS1

341

P41252
CPLPTVQIKEEALDD

RERE

1086

Q9P2R6
RAILKVPEDPTQCFL

CYB5R1

196

Q9UHQ9
SLRELNTVPICPVDK

TRAF5

71

O00463
VQVSVVDCPDLTKEP

C11orf54

31

Q9H0W9
VCSQEEPVQPLLREV

SLC7A6OS

61

Q96CW6
VIRPPLLVDKIVCRE

PLEKHG5

626

O94827
EKQVIPTRESVPCQL

TRIM77

71

I1YAP6
QQPEPISLELKTDCR

TRIM68

276

Q6AZZ1
NIVTLQPFRDKCEPV

NME8

71

Q8N427
PQEESRKVPELFVCT

MINDY4

241

Q4G0A6
SCPAELPNIKREISE

TFE3

321

P19532
PCDPQLVSERVAKLE

SPTBN2

606

O15020
ECIVQSKPVERPLVQ

SSH2

1331

Q76I76
LPPDLREQVEQVCAV

REV1

946

Q9UBZ9
LEVIKPFCVILPEIQ

SEC61A1

6

P61619
ALLTVCEEIPNPLKD

MVK

156

Q03426
LQKVLVEDPERPACA

TRPM2

536

O94759
LVDGICIKVQRPVTE

REXO5

566

Q96IC2
EPRVPTCVLQKCQVT

SPATA31D1

1271

Q6ZQQ2
DSCLNVKTPIVPVED

VWA5A

161

O00534
EIIRKLECPDPSILA

UNC13B

1121

O14795
PRVDVSCEPLEGVEK

TP53BP1

766

Q12888
VICDISPLRQIVRDP

TCF20

866

Q9UGU0
EVAIRLKVCPICQVP

ZNFX1

1611

Q9P2E3
TCQPREVVVPLTVEL

VEGFB

46

P49765
LAKEIRPQDCPISRV

FTSJ1

286

Q9UET6
CRDNVEPKKLPISEE

UBR3

1266

Q6ZT12
VNLPIVERPVCKDST

F2

526

P00734
ECEVQIVFKNPLPVT

TGM1

706

P22735
KCVNRNLTEVPTDLP

TPBG

76

Q13641
APEEVVAPLLRKVQC

TPGS1

156

Q6ZTW0
NCEVLKEVIPGVVIE

TTLL10

521

Q6ZVT0
VIEKGQTVTLRCDPI

TRBV14

31

A0A5B0
IPKRVEDILQALVVC

ZFYVE26

46

Q68DK2
TIPTVPIVDCFQKIR

TRRAP

3066

Q9Y4A5
VTVVNPLIERVKDCA

TGM6

626

O95932
ICNPEVLPIVSELLE

MYO9A

446

B2RTY4
LPKDAQPCREVISTL

MYO9B

906

Q13459