Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphosphatidylinositol binding

CCDC88A WDFY3 CGAS

2.69e-03316183GO:0035091
GeneOntologyBiologicalProcessregulation of SNARE complex assembly

VPS41 VPS16

7.50e-0515182GO:0035542
GeneOntologyBiologicalProcessendosomal vesicle fusion

VPS41 VPS16

8.57e-0516182GO:0034058
GeneOntologyBiologicalProcessSNARE complex assembly

VPS41 VPS16

2.31e-0426182GO:0035493
GeneOntologyBiologicalProcessmacroautophagy

VPS41 ADCY10 WDFY3 VPS16

2.66e-04374184GO:0016236
GeneOntologyCellularComponentAP-3 adaptor complex

VPS41 VPS16

5.43e-0513182GO:0030123
GeneOntologyCellularComponentHOPS complex

VPS41 VPS16

6.33e-0514182GO:0030897
GeneOntologyCellularComponentAP-type membrane coat adaptor complex

VPS41 VPS16

7.72e-0448182GO:0030119
GeneOntologyCellularComponentvacuolar membrane

VPS41 WDR59 WDFY3 VPS16

7.98e-04507184GO:0005774
GeneOntologyCellularComponentvesicle tethering complex

VPS41 VPS16

1.73e-0372182GO:0099023
GeneOntologyCellularComponentcoated vesicle

VPS41 CCDC88A VPS16

3.41e-03360183GO:0030135
GeneOntologyCellularComponentmembrane coat

VPS41 VPS16

3.70e-03106182GO:0030117
GeneOntologyCellularComponentcoated membrane

VPS41 VPS16

3.70e-03106182GO:0048475
GeneOntologyCellularComponentGolgi-associated vesicle

VPS41 CCDC88A

4.26e-03114182GO:0005798
GeneOntologyCellularComponentautophagosome

WDFY3 VPS16

4.63e-03119182GO:0005776
GeneOntologyCellularComponentvacuole

VPS41 WDR59 WDFY3 VPS16

6.77e-03913184GO:0005773
GeneOntologyCellularComponentlysosomal membrane

VPS41 WDR59 VPS16

6.84e-03462183GO:0005765
GeneOntologyCellularComponentlytic vacuole membrane

VPS41 WDR59 VPS16

6.84e-03462183GO:0098852
GeneOntologyCellularComponentlate endosome membrane

VPS41 VPS16

1.02e-02179182GO:0031902
DomainZnf_RING/FYVE/PHD

VPS41 HLTF WDR59 WDFY3

8.38e-04459184IPR013083
Domain-

ZC3H7B VPS41 ADCY10

9.68e-042071831.25.40.10
DomainTPR-like_helical_dom

ZC3H7B VPS41 ADCY10

1.36e-03233183IPR011990
DomainWD40_repeat_dom

VPS41 WDR59 WDFY3

2.72e-03297183IPR017986
Domain-

VPS41 WDR59 WDFY3

3.76e-033331832.130.10.10
DomainWD40/YVTN_repeat-like_dom

VPS41 WDR59 WDFY3

3.82e-03335183IPR015943
Domain-

VPS41 HLTF WDFY3

8.61e-034491833.30.40.10
DomainWD40_repeat_CS

WDR59 WDFY3

1.07e-02164182IPR019775
DomainGPCR_Rhodpsn_7TM

OR7G1 GNRHR CYSLTR1

2.51e-02670183IPR017452
DomainWD40

WDR59 WDFY3

2.53e-02259182PF00400
Domain7tm_1

OR7G1 GNRHR CYSLTR1

2.58e-02677183PF00001
DomainG_PROTEIN_RECEP_F1_1

OR7G1 GNRHR CYSLTR1

2.66e-02685183PS00237
DomainWD40

WDR59 WDFY3

2.70e-02268182SM00320
DomainG_PROTEIN_RECEP_F1_2

OR7G1 GNRHR CYSLTR1

2.72e-02691183PS50262
DomainGPCR_Rhodpsn

OR7G1 GNRHR CYSLTR1

2.73e-02692183IPR000276
DomainWD40_repeat

WDR59 WDFY3

2.77e-02272182IPR001680
DomainWD_REPEATS_1

WDR59 WDFY3

2.89e-02278182PS00678
DomainWD_REPEATS_2

WDR59 WDFY3

2.91e-02279182PS50082
DomainWD_REPEATS_REGION

WDR59 WDFY3

2.91e-02279182PS50294
DomainZF_RING_1

VPS41 HLTF

3.14e-02291182PS00518
DomainZF_RING_2

VPS41 HLTF

3.28e-02298182PS50089
PathwayKEGG_MEDICUS_PATHOGEN_SALMONELLA_SIFA_TO_TETHERING_OF_LATE_ENDOSOMES_AND_LYSOSOMES

VPS41 VPS16

3.79e-059152M47777
PathwayKEGG_MEDICUS_REFERENCE_TETHERING_OF_LATE_ENDOSOMES_AND_LYSOSOMES

VPS41 VPS16

4.73e-0510152M47776
PathwayREACTOME_SARS_COV_2_MODULATES_AUTOPHAGY

VPS41 VPS16

5.78e-0511152M45018
PathwayKEGG_MEDICUS_REFERENCE_AUTOPHAGOSOME_AND_LYSOSOME_FUSION_TETHERING_FACTOR

VPS41 VPS16

1.26e-0416152M47978
PathwayWP_PERTURBATIONS_TO_HOSTCELL_AUTOPHAGY_INDUCED_BY_SARSCOV2_PROTEINS

VPS41 VPS16

9.74e-0444152M46452
Pubmed

Loss-of-Function Variants in HOPS Complex Genes VPS16 and VPS41 Cause Early Onset Dystonia Associated with Lysosomal Abnormalities.

VPS41 VPS16

2.83e-07219232808683
Pubmed

The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways.

VPS41 WDR59 VPS16

7.46e-073319333452816
Pubmed

Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b.

VPS41 VPS16

4.24e-06619221802320
Pubmed

RILP interacts with HOPS complex via VPS41 subunit to regulate endocytic trafficking.

VPS41 VPS16

5.93e-06719225445562
Pubmed

Structural basis of Vps33A recruitment to the human HOPS complex by Vps16.

VPS41 VPS16

7.90e-06819223901104
Pubmed

Identification of the switch in early-to-late endosome transition.

VPS41 VPS16

7.90e-06819220434987
Pubmed

The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17.

VPS41 VPS16

7.90e-06819224554770
Pubmed

Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes.

VPS41 VPS16

7.90e-06819225783203
Pubmed

SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery.

VPS41 VPS16

7.90e-06819219109425
Pubmed

An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex.

VPS41 VPS16

1.27e-051019218799622
Pubmed

Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity.

VPS41 VPS16

1.27e-051019226463206
Pubmed

Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells.

VPS41 VPS16

1.86e-051219221411634
Pubmed

Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton.

VPS41 VPS16

3.83e-051719214668490
Pubmed

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.

VPS41 VPS16

4.81e-051919233422265
InteractionPLEKHM1 interactions

VPS41 WDR59 VPS16

2.01e-0557193int:PLEKHM1
InteractionTECPR2 interactions

VPS41 VPS16

1.14e-0417192int:TECPR2
InteractionCCDC127 interactions

VPS16 CGAS

1.43e-0419192int:CCDC127
InteractionSULT1C4 interactions

VPS41 WDR59 VPS16

1.44e-04110193int:SULT1C4
InteractionMON1B interactions

VPS41 VPS16

1.92e-0422192int:MON1B
InteractionUEVLD interactions

WDR59 CGAS

2.11e-0423192int:UEVLD
InteractionRILP interactions

VPS41 VPS16

2.70e-0426192int:RILP
GeneFamilyWD repeat domain containing

WDR59 WDFY3

1.06e-02262112362
ComputationalNeighborhood of BMPR2

VPS41 MTRF1L

8.40e-045392MORF_BMPR2
ComputationalNeighborhood of ZNF10

VPS41 MTRF1L

8.40e-045392MORF_ZNF10
ComputationalNeighborhood of RAB3A

VPS41 MTRF1L

2.35e-038992MORF_RAB3A
ComputationalNeighborhood of WNT1

VPS41 MTRF1L

3.38e-0310792MORF_WNT1
ComputationalNeighborhood of FRK

VPS41 MTRF1L

3.56e-0311092MORF_FRK
ComputationalNeighborhood of DCC

VPS41 MTRF1L

3.69e-0311292MORF_DCC
ComputationalNeighborhood of MAP3K14

VPS41 MTRF1L

4.30e-0312192MORF_MAP3K14
ComputationalNeighborhood of LCAT

VPS41 MTRF1L

5.17e-0313392MORF_LCAT
ComputationalNeighborhood of EPHA7

VPS41 MTRF1L

5.63e-0313992MORF_EPHA7

Protein segments in the cluster

PeptideGeneStartEntry
LASASAKLKIRKAML

CCDC148

41

Q8NFR7
AKLKIRKAMLTSKLS

CCDC148

46

Q8NFR7
MLQKLKSLHLKKKTL

CAGE1

651

Q8TC20
DLLIQKRKKLKKSSM

ARHGEF33

446

A8MVX0
SLLGKKKMRILILSL

ARL17A

11

Q8IVW1
QIVLAKKMLRKALKL

ADCY10

1146

Q96PN6
KKMLRKALKLLNRIF

ADCY10

1151

Q96PN6
LSASKMLSKFRKIIK

CGAS

271

Q8N884
ITLKMRKLIKSKKDI

CCDC88A

1396

Q3V6T2
TVLKSKMLAKKLLGL

LPO

586

P22079
SLRNKEMKKALRKLI

OR7G1

291

Q8NGA0
KKLSRMKLLLKHLTL

GNRHR

71

P30968
RKKLIRKMKLILSSG

HLTF

741

Q14527
LKNKELAMTKLRAKL

MTRF1L

281

Q9UGC7
MIILTLLKKSMKKNL

CYSLTR1

211

Q9Y271
LLAMLLKKKRSLLNS

WDFY3

1456

Q8IZQ1
LLLKMKRSKLALSKA

VPS16

551

Q9H269
TASRKLLLKSLMLAK

TNNI1

11

P19237
KKILVADSLSLLKKM

VPS41

761

P49754
TMKAKLLKILKDTAL

WDR59

456

Q6PJI9
LKQKLAKARKDMLLC

ZC3H7B

926

Q9UGR2