Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	CCDC88A TAGAP ARHGAP26 TBC1D7 SGSM3 ARHGEF2 RIC1 MADD	6.09e-05	507	54	8	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	CCDC88A TAGAP ARHGAP26 TBC1D7 SGSM3 ARHGEF2 RIC1 MADD	6.09e-05	507	54	8	GO:0030695
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	CCDC88A TAGAP ARHGEF2 RIC1 MADD	3.96e-04	231	54	5	GO:0005085
GeneOntologyBiologicalProcess	regulation of cilium assembly	CCDC88A TBC1D7 SYNE2 SGSM3 KCTD17	8.42e-06	108	53	5	GO:1902017
GeneOntologyBiologicalProcess	regulation of organelle assembly	CCDC88A TBC1D7 SYNE2 SGSM3 ARHGEF2 KCTD17	7.97e-05	280	53	6	GO:1902115
GeneOntologyBiologicalProcess	actin filament-based process	AKAP6 AP1AR CCDC88A DSP INPP5K ARHGAP26 SPTBN1 SYNE2 CASQ1 ARHGEF2	9.39e-05	912	53	10	GO:0030029
GeneOntologyCellularComponent	Dsl1/NZR complex	RINT1 ZW10	2.04e-05	3	55	2	GO:0070939
GeneOntologyCellularComponent	sarcoplasmic reticulum membrane	AKAP6 SYNE2 CASQ1	2.26e-04	45	55	3	GO:0033017
Domain	Spectrin/alpha-actinin	AKAP6 DST DSP SPTBN1 SYNE2	2.88e-08	32	53	5	IPR018159
Domain	SPEC	AKAP6 DST DSP SPTBN1 SYNE2	2.88e-08	32	53	5	SM00150
Domain	Spectrin_repeat	DST DSP SPTBN1 SYNE2	1.30e-06	29	53	4	IPR002017
Domain	Actinin_actin-bd_CS	DST SPTBN1 SYNE2	3.67e-05	23	53	3	IPR001589
Domain	Spectrin	DST SPTBN1 SYNE2	3.67e-05	23	53	3	PF00435
Domain	ACTININ_2	DST SPTBN1 SYNE2	3.67e-05	23	53	3	PS00020
Domain	ACTININ_1	DST SPTBN1 SYNE2	3.67e-05	23	53	3	PS00019
Domain	-	DST DSP	1.18e-04	6	53	2	3.90.1290.10
Domain	Plectin_repeat	DST DSP	1.64e-04	7	53	2	IPR001101
Domain	Plectin	DST DSP	1.64e-04	7	53	2	PF00681
Domain	PLEC	DST DSP	1.64e-04	7	53	2	SM00250
Domain	CH	DST SPTBN1 SYNE2	8.32e-04	65	53	3	SM00033
Domain	CH	DST SPTBN1 SYNE2	1.03e-03	70	53	3	PF00307
Domain	-	DST SPTBN1 SYNE2	1.08e-03	71	53	3	1.10.418.10
Domain	CH	DST SPTBN1 SYNE2	1.17e-03	73	53	3	PS50021
Domain	RUN	PLEKHM2 SGSM3	1.17e-03	18	53	2	SM00593
Domain	CH-domain	DST SPTBN1 SYNE2	1.26e-03	75	53	3	IPR001715
Domain	RUN	PLEKHM2 SGSM3	1.31e-03	19	53	2	PS50826
Domain	RUN	PLEKHM2 SGSM3	1.31e-03	19	53	2	PF02759
Domain	Run_dom	PLEKHM2 SGSM3	1.31e-03	19	53	2	IPR004012
Domain	SANT_dom	MTA2 NCOR2	2.46e-03	26	53	2	IPR017884
Domain	SANT	MTA2 NCOR2	2.85e-03	28	53	2	PS51293
Domain	PH	PLEKHM2 ARHGAP26 SPTBN1 ARHGEF2	4.03e-03	229	53	4	PF00169
Domain	Myb_DNA-binding	MTA2 NCOR2	4.43e-03	35	53	2	PF00249
Domain	MYB_LIKE	MTA2 NCOR2	5.20e-03	38	53	2	PS50090
Domain	SET	PRDM15 PRDM1	7.55e-03	46	53	2	SM00317
Domain	PH	PLEKHM2 ARHGAP26 SPTBN1 ARHGEF2	7.94e-03	278	53	4	SM00233
Domain	PH_DOMAIN	PLEKHM2 ARHGAP26 SPTBN1 ARHGEF2	8.04e-03	279	53	4	PS50003
Domain	PH_domain	PLEKHM2 ARHGAP26 SPTBN1 ARHGEF2	8.14e-03	280	53	4	IPR001849
Domain	SET_dom	PRDM15 PRDM1	8.87e-03	50	53	2	IPR001214
Domain	SANT	MTA2 NCOR2	8.87e-03	50	53	2	SM00717
Domain	SET	PRDM15 PRDM1	8.87e-03	50	53	2	PS50280
Domain	SANT/Myb	MTA2 NCOR2	9.57e-03	52	53	2	IPR001005
Pathway	REACTOME_RND3_GTPASE_CYCLE	CCDC88A DST DSP	2.42e-04	42	41	3	M41826
Pathway	REACTOME_RND1_GTPASE_CYCLE	CCDC88A DST DSP	2.42e-04	42	41	3	M41828
Pathway	REACTOME_RND3_GTPASE_CYCLE	CCDC88A DST DSP	2.42e-04	42	41	3	MM15677
Pathway	REACTOME_RHO_GTPASE_CYCLE	CCDC88A DST DSP TAGAP ARHGAP26 SPTBN1 ARHGEF2	2.43e-04	439	41	7	MM15595
Pathway	REACTOME_RND1_GTPASE_CYCLE	CCDC88A DST DSP	2.60e-04	43	41	3	MM15679
Pathway	REACTOME_RHO_GTPASE_CYCLE	CCDC88A DST DSP TAGAP ARHGAP26 SPTBN1 ARHGEF2	2.83e-04	450	41	7	M27078
Pathway	WP_NOTCH_SIGNALING_WP268	NCOR2 INPP5K NOTCH3	2.98e-04	45	41	3	M39571
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	CCDC88A DST DSP TAGAP ARHGAP26 SPTBN1 ARHGEF2 ZW10	4.79e-04	649	41	8	MM15690
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	CCDC88A DST DSP TAGAP ARHGAP26 SPTBN1 ARHGEF2 ZW10	9.49e-04	720	41	8	M41838
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MTA2 NCOR2 DST SZT2 PLEKHM2 ARHGAP26 ANKLE1 REV3L ARHGEF2 HCFC1 RIC1 MADD	1.53e-07	1105	56	12	35748872
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	AKAP6 NCOR2 CCDC88A DST SPTBN1	4.61e-06	151	56	5	17043677
Pubmed	Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis.	RINT1 ZW10	7.63e-06	3	56	2	17699596
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	AKAP6 DST DSP SPTBN1 SYNE2 CIPC NOTCH3	1.48e-05	497	56	7	23414517
Pubmed	RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex.	RINT1 ZW10	1.52e-05	4	56	2	16571679
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	RINT1 DST PLEKHM2 SYNE2 ZW10 RIC1 MADD	1.62e-05	504	56	7	34432599
Pubmed	Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery.	RINT1 ZW10	2.54e-05	5	56	2	20462495
Pubmed	Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex.	NCOR2 INPP5K	2.54e-05	5	56	2	11509665
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	RINT1 DST DSP SPTBN1 SYNE2 ZW10 HCFC1	3.46e-05	568	56	7	37774976
Pubmed	The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity.	NCOR2 NOTCH3	3.80e-05	6	56	2	11404076
Pubmed	Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport.	RINT1 ZW10	3.80e-05	6	56	2	19369418
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	NCOR2 RINT1 SAAL1 CCDC88A DSP SPTBN1 SYNE2 ARHGEF2 MADD	4.23e-05	1049	56	9	27880917
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	CCDC88A DST SYNE2 HCFC1	4.75e-05	123	56	4	26912792
Pubmed	PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex.	RINT1 ZW10	5.32e-05	7	56	2	24056303
Pubmed	Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion.	RINT1 ZW10	5.32e-05	7	56	2	15272311
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	MTA2 NCOR2 SERPINB6 DST DSP SPTBN1 DDX51 UBXN1 ARHGEF2 SRBD1	5.35e-05	1353	56	10	29467282
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	NCOR2 RINT1 DSP REV3L ARHGEF2 PRDM15 HCFC1 NOTCH3	6.57e-05	857	56	8	25609649
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	RINT1 CCDC88A DST ARHGEF2 HCFC1 RIC1 MADD	8.08e-05	650	56	7	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MTA2 DST DSP SPTBN1 SYNE2 DDX51 HCFC1	8.32e-05	653	56	7	22586326
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	MTA2 RINT1 SAAL1 DSP SPTBN1 RANBP6 ZW10	8.64e-05	657	56	7	36180527
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	MTA2 RINT1 SAAL1 DST SPTBN1 SYNE2 RANBP6 ARHGEF2 ZW10 HCFC1	8.98e-05	1440	56	10	30833792
Pubmed	Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.	DST DSP	9.10e-05	9	56	2	12482924
Pubmed	Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.	CCDC88A SPTBN1 ARHGEF2 MADD	9.48e-05	147	56	4	16959763
Pubmed	Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi.	RINT1 ZW10	1.14e-04	10	56	2	15029241
Pubmed	Sharp, an inducible cofactor that integrates nuclear receptor repression and activation.	MTA2 NCOR2	1.39e-04	11	56	2	11331609
Pubmed	The proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation.	MTA2 NCOR2	1.39e-04	11	56	2	23658227
Pubmed	Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.	DST DSP	1.39e-04	11	56	2	12802069
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NCOR2 CCDC88A DST UBE2V2 SPTBN1 TBC1D7 SYNE2 ARHGEF2	1.47e-04	963	56	8	28671696
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	DSP ARHGEF2 CARD14 MADD	1.55e-04	167	56	4	25659891
Pubmed	The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes.	PLEKHM2 INPP5K	1.96e-04	13	56	2	28325809
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	AKAP6 SERPINB6 DST SPTBN1 TBC1D7 SGSM3 UBXN1 REV3L KCTD17	2.07e-04	1293	56	9	15342556
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	DSP SPTBN1 ARHGEF2 SRBD1 HCFC1	2.20e-04	340	56	5	24332808
Pubmed	ZW10 links mitotic checkpoint signaling to the structural kinetochore.	RINT1 ZW10	2.29e-04	14	56	2	15824131
Pubmed	O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry.	SPTBN1 HCFC1	2.29e-04	14	56	2	16452088
Pubmed	Transcriptional map of chromosome region 6q16-->q21.	REV3L PRDM1	2.29e-04	14	56	2	10575223
Pubmed	The REV7 subunit of DNA polymerase ζ is essential for primordial germ cell maintenance in the mouse.	REV3L PRDM1	3.01e-04	16	56	2	23463509
Pubmed	Spatiotemporal regulation of GLI target genes in the mammalian limb bud.	ADAMTS19 NCOR2 BAZ2B PRDM1	3.51e-04	207	56	4	26238476
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NWD2 SYNE2 ARHGEF2	3.81e-04	87	56	3	12465718
Pubmed	Scanning the human proteome for calmodulin-binding proteins.	AKAP6 DST SYNE2	4.49e-04	92	56	3	15840729
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CCDC88A DST DSP SPTBN1 SYNE2 ARHGEF2 MADD	4.49e-04	861	56	7	36931259
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	BAZ2B REV3L ARHGEF2 HCFC1	4.58e-04	222	56	4	37071664
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	AP1AR RINT1 DST DSP FAM186A SPTBN1 SYNE2 ARHGEF2 SRBD1	4.61e-04	1442	56	9	35575683
Pubmed	FOXK2 Elicits Massive Transcription Repression and Suppresses the Hypoxic Response and Breast Cancer Carcinogenesis.	MTA2 NCOR2	4.75e-04	20	56	2	27773593
Pubmed	Evolutionary breakpoints on human chromosome 21.	PRDM15 NOTCH3	4.75e-04	20	56	2	11707078
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	NCOR2 ARHGAP26 SYNE2 DDX51 REV3L ARHGEF2	5.55e-04	638	56	6	31182584
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	DNHD1 DST DSP FAM186A	5.58e-04	234	56	4	36243803
Pubmed	Aberrant epidermal differentiation and disrupted ΔNp63/Notch regulatory axis in Ets1 transgenic mice.	NOTCH3 PRDM1	6.30e-04	23	56	2	24337118
Pubmed	Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells.	MTA2 HCFC1	6.30e-04	23	56	2	21670149
Pubmed	Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.	AP1AR RINT1 SERPINB6 SAAL1 RANBP6 UBXN1 ZW10	7.13e-04	931	56	7	27432908
Pubmed	NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.	DSP SPTBN1	7.46e-04	25	56	2	30309841
Pubmed	Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.	TAGAP PRDM1	7.46e-04	25	56	2	19898481
Pubmed	Epidermal development requires ninein for spindle orientation and cortical microtubule organization.	DSP NOTCH3	8.07e-04	26	56	2	30923192
Pubmed	NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.	MTA2 NCOR2	8.71e-04	27	56	2	23395962
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	CCDC88A DST SPTBN1	9.72e-04	120	56	3	31413325
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	AKAP6 DST DSP SPTBN1 CIPC SGSM3 REV3L MADD	9.98e-04	1285	56	8	35914814
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	NCOR2 NWD2 DSP SPTBN1 MADD	1.00e-03	475	56	5	31040226
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	MTA2 NCOR2 DST DSP BAZ2B DDX51 SRBD1 HCFC1	1.04e-03	1294	56	8	30804502
Pubmed	The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.	SPTBN1 SYNE2	1.08e-03	30	56	2	30480076
Pubmed	A human MAP kinase interactome.	CCDC88A DST DSP SPTBN1 MADD	1.11e-03	486	56	5	20936779
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	DST DSP SPTBN1 HCFC1	1.15e-03	284	56	4	29459677
Pubmed	E3 Ubiquitin Ligase UBR5 Promotes the Metastasis of Pancreatic Cancer via Destabilizing F-Actin Capping Protein CAPZA1.	DSP SPTBN1	1.15e-03	31	56	2	33777788
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	ARHGEF2 HCFC1 NOTCH3	1.20e-03	129	56	3	23022380
Pubmed	ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis.	RINT1 SYNE2 UBXN1 ZW10	1.38e-03	299	56	4	37931956
Pubmed	Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.	MTA2 HCFC1	1.46e-03	35	56	2	22325351
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	MTA2 NCOR2 SAAL1 DSP SPTBN1 SYNE2 UBXN1 HCFC1	1.48e-03	1367	56	8	32687490
Pubmed	Gene expression in the developing mouse retina by EST sequencing and microarray analysis.	RINT1 DST MADD	1.58e-03	142	56	3	11812828
Cytoband	9p24.1	RANBP6 RIC1	8.00e-04	34	56	2	9p24.1
Cytoband	8p23.1	ZNF705B ZNF705D ZNF705G	9.01e-04	154	56	3	8p23.1
GeneFamily	EF-hand domain containing\|Plakins	DST DSP	9.54e-05	8	34	2	939
GeneFamily	Zinc fingers C2H2-type\|PR/SET domain family	PRDM15 PRDM1	4.59e-04	17	34	2	1197
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF705A ZNF705B PRDM15 ZNF705D ZNF705G PRDM1	2.00e-03	718	34	6	28
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	TAGAP ARHGAP26	3.97e-03	50	34	2	721
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	MTA2 NCOR2	4.45e-03	53	34	2	532
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHM2 SPTBN1 ARHGEF2	6.73e-03	206	34	3	682
Coexpression	BUSSLINGER_GASTRIC_X_CELLS	AP1AR SERPINB6 DST DSP BAZ2B REV3L	2.39e-06	191	53	6	M40019
Coexpression	XIE_TRASTUZUMAB_CARDIOTOXICITY_MMU_MIR_345_5P_GENES	NCOR2 PLEKHM2 CIPC MADD	2.10e-05	80	53	4	MM17502
Coexpression	GSE3039_ALPHABETA_CD8_TCELL_VS_B2_BCELL_UP	CCDC88A SZT2 CIPC PRDM15 MADD	5.12e-05	199	53	5	M6443
Coexpression	GSE35435_RESTING_VS_IL4_TREATED_MACROPHAGE_DN	DST FAM186A FAM131B PRDM1 AHSP	5.12e-05	199	53	5	M9543
Coexpression	GSE28737_FOLLICULAR_VS_MARGINAL_ZONE_BCELL_BCL6_HET_UP	RINT1 SZT2 INPP5K ARHGAP26 CIPC	5.24e-05	200	53	5	M9354
Coexpression	GSE17721_CTRL_VS_LPS_4H_BMDC_UP	AP1AR NCOR2 SGSM3 REV3L HCFC1	5.24e-05	200	53	5	M3689
CoexpressionAtlas	dev gonad_e13.5_M_InterstitFLeydig_MafB_k-means-cluster#1_top-relative-expression-ranked_1000	ADAMTS19 SERPINB6 TAGAP SYNE2 REV3L	1.49e-05	125	53	5	gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_k1_1000
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-8\|TCGA-Kidney / Sample_Type by Project: Shred V9	ZNF705EP ZNF705B NMRK2 ZNF705D ZNF705G	4.81e-07	123	56	5	967f20fcb27c9989de93f4183038334105910175
ToppCell	BAL-Control-Lymphocyte-T/NK-CD4+_T-Treg-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PI16 SYNE2 OLFM2 PRDM1 AHSP	4.09e-06	190	56	5	c3c7de22657a86495939456bc22eac61c93db8b2
ToppCell	BAL-Control-Lymphocyte-T/NK-CD4+_T-Treg\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PI16 SYNE2 OLFM2 PRDM1 AHSP	4.09e-06	190	56	5	166119c037d80fee852567a9cc53c4143dd19037
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD3-NKT\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ZNF705A TAGAP SYNE2 ZNF705G PRDM1	5.00e-06	198	56	5	9ce9b3721fb8a154667211c29e60133412134c76
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD3\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ZNF705A TAGAP SYNE2 ZNF705G PRDM1	5.00e-06	198	56	5	3c23fb8a84d4e4a20f7fa60055c7b37fc45a29d5
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF705EP SYNE2 OLFM2 PRDM1	4.22e-05	154	56	4	89c9c9918af32f3952790b41f1471b2c80ffce2f
ToppCell	Leuk-UTI-Lymphocyte-T_NK-CD4_CTL\|Leuk-UTI / Disease, Lineage and Cell Type	ZNF705A SYNE2 OLFM2 PRDM1	4.22e-05	154	56	4	170a421fd69dba2929568c72e983ae9cfaf2aabc
ToppCell	URO-Lymphocyte-T_NK-CD4_CTL\|URO / Disease, Lineage and Cell Type	TAGAP SYNE2 OLFM2 PRDM1	5.14e-05	162	56	4	1afeeb17e263cf625a4f285203cf82f973735193
ToppCell	COVID-19_Moderate-Treg\|World / disease group, cell group and cell class	PI16 SYNE2 OLFM2 PRDM1	6.06e-05	169	56	4	27ad11239559b025bef582f89b2a83501d9d3993
ToppCell	Healthy_Control-Lymphoid-T-Treg\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	PI16 SYNE2 PRDM1 AHSP	7.09e-05	176	56	4	7765a5b04ac117d525201f8eb08e1754e55942ff
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	DST DSP BAZ2B SYNE2	8.25e-05	183	56	4	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PI16 SYNE2 OLFM2 PRDM1	8.42e-05	184	56	4	08bff25390e3484b75c860738396a405141b69fd
ToppCell	IPF-Lymphoid-T_Regulatory\|IPF / Disease state, Lineage and Cell class	SYNE2 ADAT2 PRDM1 AHSP	8.60e-05	185	56	4	221cbd09d94cc0947d0e3c1aa14716d17cb2068d
ToppCell	IPF-Lymphoid-T_Regulatory\|World / Disease state, Lineage and Cell class	SYNE2 ADAT2 PRDM1 AHSP	8.60e-05	185	56	4	77fbecdab10bacc005b1c7e22ca414cfecef13c1
ToppCell	normal-na-Lymphocytic_T-CytoT_GZMH+-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	FAM186A SYNE2 PRDM1 AHSP	8.60e-05	185	56	4	097d628f92e13250c15b550f2fd1f4225fc07558
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTS19 PI16 SPTBN1 NMRK2	8.60e-05	185	56	4	d5f5866924648a3c14e2596218fd548a31777aa3
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PI16 SYNE2 OLFM2 PRDM1	8.96e-05	187	56	4	9fdfca5b70f585843ef9d810154674a8e561e765
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PI16 SYNE2 OLFM2 PRDM1	8.96e-05	187	56	4	a525753a8a908ee1ef0b8f06e68855e4af27bf86
ToppCell	Int-URO-Lymphocyte-T_NK-CD4_TCM\|Int-URO / Disease, Lineage and Cell Type	PI16 TAGAP SYNE2 PRDM1	8.96e-05	187	56	4	9a137961d33c6b440f1e5ef40360a365e3c03ab2
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-Plasma_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	RINT1 UBE2V2 RIC1 PRDM1	9.15e-05	188	56	4	34873972dff9284dfcd26bb698c9d1df007f1cbb
ToppCell	Leuk-UTI-Lymphocyte-T_NK-CD4_TCM\|Leuk-UTI / Disease, Lineage and Cell Type	PI16 TAGAP SYNE2 PRDM1	9.53e-05	190	56	4	5f8d606d2f465ddeae7451835f84b3f25a151d2a
ToppCell	normal_Pleural_Fluid-T/NK_cells-Treg\|T/NK_cells / Location, Cell class and cell subclass	SYNE2 ANKLE1 ADAT2 PRDM1	9.53e-05	190	56	4	519356c4925b5b6647e7d763d4084cd9b2e94f0a
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP BAZ2B SPTBN1 SYNE2	9.73e-05	191	56	4	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 CASQ1 NMRK2 NOTCH3	9.73e-05	191	56	4	f932980baa032748857cb367a55c37dd975c693e
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP BAZ2B SPTBN1 SYNE2	9.73e-05	191	56	4	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP BAZ2B SPTBN1 SYNE2	9.73e-05	191	56	4	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	Healthy-Treg\|World / disease group, cell group and cell class	PI16 SYNE2 OLFM2 PRDM1	1.01e-04	193	56	4	e22bfcd170ba23e313512f0f07c658fcf6ae1b97
ToppCell	Control-Myeloid-cDC1\|Control / Disease, Lineage and Cell Type	SERPINB6 CCDC88A DST UBE2V2	1.05e-04	195	56	4	35b2fe0588877d30cbd5d3ae259fcfd959907429
ToppCell	COVID_non-vent-Lymphocytic-T_cell-CD4+_Memory_T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	DST SPTBN1 SYNE2 PRDM1	1.05e-04	195	56	4	22191d361af136942508f1553ff41a626ed982ad
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-IPC/newborn-38\|World / Primary Cells by Cluster	BAZ2B SYNE2 UBXN1 ARHGEF2	1.07e-04	196	56	4	38da0751941adca650fe9b383d9f343153978eb5
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-IPC/newborn\|World / Primary Cells by Cluster	BAZ2B SYNE2 UBXN1 ARHGEF2	1.07e-04	196	56	4	721650a08d260faf530dbd52d4e9275d27f3bac2
ToppCell	COVID-19-Heart-Mito_CM\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AKAP6 DSP CASQ1 NMRK2	1.10e-04	197	56	4	44e49943d62bfe622b40ad0460093d31540544df
ToppCell	Sepsis-URO-Lymphocyte-T/NK-CD4+_CTL\|URO / Disease, condition lineage and cell class	TAGAP SYNE2 OLFM2 PRDM1	1.12e-04	198	56	4	c53405a8d082fbd10131a6ec88b69fdd835f2925
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	DST BAZ2B SYNE2 REV3L	1.14e-04	199	56	4	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-T/NK-CD4+_Tcm\|Leuk-UTI / Disease, condition lineage and cell class	PI16 TAGAP SYNE2 PRDM1	1.14e-04	199	56	4	22a16381ad68e758aa8e44fa0d6d5a2335aa5fe3
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DST BAZ2B SPTBN1 SYNE2	1.16e-04	200	56	4	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	control\|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DST DSP SPTBN1 SYNE2	1.16e-04	200	56	4	97f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell	Control_saline-Endothelial-Endothelial-Gen_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	DST BAZ2B SPTBN1 REV3L	1.16e-04	200	56	4	3b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Artery\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SERPINB6 DST PI16 SYNE2	1.16e-04	200	56	4	77ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SERPINB6 DST SPTBN1 SYNE2	1.16e-04	200	56	4	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-CD4+_Tcm\|Int-URO / Disease, condition lineage and cell class	PI16 TAGAP SYNE2 PRDM1	1.16e-04	200	56	4	848d1f9ae79dc9d012c89fcd5cf8f2f1a7ef8e13
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DST BAZ2B SPTBN1 SYNE2	1.16e-04	200	56	4	a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-Treg\|Int-URO / Disease, condition lineage and cell class	SYNE2 OLFM2 ZW10 PRDM1	1.16e-04	200	56	4	47f265336bc3b8052c0cac730ac9afd41cd8fc43
ToppCell	Sepsis-URO-Lymphocyte-T/NK-CD4+_Tcm\|URO / Disease, condition lineage and cell class	PI16 TAGAP SYNE2 PRDM1	1.16e-04	200	56	4	4689fd4c6e7f078d7e91783a1646dd85c03cba77
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / Treatment groups by lineage, cell group, cell type	SERPINB6 DST PI16 SYNE2	1.16e-04	200	56	4	b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Artery\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SERPINB6 DST PI16 SYNE2	1.16e-04	200	56	4	b1ff8d61b567f85006d6d20093f9c803b6d34674
Drug	S(-)Eticlopride hydrochloride [97612-24-3]; Down 200; 10.6uM; HL60; HT_HG-U133A	NCOR2 SZT2 DSP SGSM3 MADD PRDM1	5.68e-06	197	52	6	3056_DN
Drug	Niridazole [61-57-4]; Down 200; 18.6uM; PC3; HT_HG-U133A	AP1AR CCDC88A SGSM3 FAM131B NOTCH3 MADD	5.85e-06	198	52	6	4621_DN
Drug	PHA-00745360 [351320-33-7]; Down 200; 1uM; PC3; HT_HG-U133A	MTA2 NCOR2 SPTBN1 SGSM3 UBXN1 HCFC1	6.02e-06	199	52	6	4562_DN
Drug	plakin	DST DSP SPTBN1 SYNE2	3.71e-05	82	52	4	CID000018752
Drug	haloperidol; Up 200; 10uM; MCF7; HT_HG-U133A	INPP5K SPTBN1 SGSM3 HCFC1 CARD14	7.08e-05	189	52	5	6960_UP
Drug	Doxazosin mesylate [77883-43-3]; Up 200; 7.4uM; MCF7; HT_HG-U133A	NCOR2 SZT2 DDX51 ARHGEF2 AHSP	8.01e-05	194	52	5	3363_UP
Drug	Imidurea [39236-46-9]; Up 200; 10.4uM; MCF7; HT_HG-U133A	AKAP6 MTA2 NCOR2 ARHGEF2 HCFC1	8.21e-05	195	52	5	3522_UP
Drug	Clenbuterol hydrochloride [21898-19-1]; Up 200; 12.8uM; MCF7; HT_HG-U133A	DDX51 HSF4 CARD14 PRDM1 AHSP	8.21e-05	195	52	5	5631_UP
Drug	AG-028671 [847803-03-6]; Up 200; 10uM; PC3; HT_HG-U133A	PLEKHM2 BAZ2B INPP5K ARHGAP26 FAM131B	8.21e-05	195	52	5	6557_UP
Drug	Mefenamic acid [61-68-7]; Up 200; 16.6uM; PC3; HT_HG-U133A	CCDC88A DSP ARHGAP26 SYNE2 SGSM3	8.41e-05	196	52	5	1821_UP
Drug	Amiodarone hydrochloride [19774-82-4]; Up 200; 5.8uM; MCF7; HT_HG-U133A	MTA2 NCOR2 SZT2 CARD14 PRDM1	8.41e-05	196	52	5	5253_UP
Drug	Phenelzine sulfate [156-51-4]; Down 200; 17uM; PC3; HT_HG-U133A	MTA2 SZT2 PLEKHM2 UBXN1 HCFC1	8.41e-05	196	52	5	4538_DN
Drug	Vancomycin hydrochloride [1404-93-9]; Down 200; 2.6uM; MCF7; HT_HG-U133A	SZT2 SPTBN1 UBXN1 HCFC1 CARD14	8.41e-05	196	52	5	4423_DN
Drug	3-nitropropionic acid; Down 200; 10uM; MCF7; HT_HG-U133A	CCDC88A ARHGAP26 UBXN1 HSF4 CARD14	8.41e-05	196	52	5	6367_DN
Drug	Anabasine [494-52-0]; Up 200; 24.6uM; MCF7; HT_HG-U133A	NCOR2 PLEKHM2 SPTBN1 ZW10 HSF4	8.41e-05	196	52	5	6774_UP
Drug	Cinchonine [118-10-5]; Up 200; 13.6uM; HL60; HT_HG-U133A	CCDC88A DDX51 SGSM3 KCTD17 PRDM1	8.41e-05	196	52	5	2133_UP
Drug	(-) -Levobunolol hydrochloride [27912-14-7]; Up 200; 12.2uM; MCF7; HT_HG-U133A	NCOR2 SZT2 SPTBN1 CARD14 AHSP	8.61e-05	197	52	5	4134_UP
Drug	Vincamine [1617-90-9]; Down 200; 11.2uM; MCF7; HT_HG-U133A	MTA2 NCOR2 UBXN1 ARHGEF2 HCFC1	8.61e-05	197	52	5	2327_DN
Drug	Reserpinic acid hydrochloride; Down 200; 9.2uM; PC3; HT_HG-U133A	SZT2 SPTBN1 SGSM3 UBXN1 ARHGEF2	8.82e-05	198	52	5	6603_DN
Drug	Sulconazole nitrate [61318-91-0]; Up 200; 8.6uM; PC3; HT_HG-U133A	NCOR2 UBXN1 HCFC1 CARD14 AHSP	8.82e-05	198	52	5	6652_UP
Drug	Sulfinpyrazone [57-96-5]; Up 200; 9.8uM; MCF7; HT_HG-U133A	NCOR2 SPTBN1 SGSM3 UBXN1 HCFC1	8.82e-05	198	52	5	6230_UP
Drug	Etofylline [519-37-9]; Up 200; 17.8uM; PC3; HT_HG-U133A	SZT2 ARHGAP26 DDX51 NOTCH3 MADD	9.03e-05	199	52	5	5048_UP
Drug	Orphenadrine hydrochloride [341-69-5]; Down 200; 13uM; PC3; HT_HG-U133A	CCDC88A SPTBN1 UBXN1 SRBD1 HCFC1	9.03e-05	199	52	5	4537_DN
Drug	Cefuroxime sodium salt [56238-63-2]; Down 200; 9uM; PC3; HT_HG-U133A	MTA2 CCDC88A SPTBN1 ARHGEF2 NOTCH3	9.03e-05	199	52	5	5787_DN
Drug	Hydrocortisone base [50-23-7]; Down 200; 11uM; MCF7; HT_HG-U133A	AP1AR RINT1 INPP5K REV3L ARHGEF2	9.25e-05	200	52	5	5284_DN
Disease	Hirschsprung disease	DDX51 CARD14	6.02e-04	21	51	2	MONDO_0018309

Protein segments in the cluster

Peptide	Gene	Start	Entry
ASDMLHMRWDEELAA	PI16	51	Q6UXB8
SVSAEETEKWMEEAM	ADAT2	16	Q7Z6V5
SIDSDMATLWLTEDE	ANKLE1	326	Q8NAG6
LVSEEDMVTVVEDWM	AHSP	31	Q9NZD4
DIVENWSVEEQAMEM	BAZ2B	1781	Q9UIF8
WSVEEQAMEMDLSVL	BAZ2B	1786	Q9UIF8
EMDEKDFAADSWSLA	ARHGEF2	206	Q92974
LDLEWEDEEGMNRML	AP1AR	206	Q63HQ0
AEMEEALLEWGTLAM	DNHD1	1521	Q96M86
EMVMVDSEGSLSVWN	NWD2	1156	Q9ULI1
CRDEMEEWSASEAML	MTA2	261	O94776
EEWSASEAMLFEEAL	MTA2	266	O94776
SDMDFMVDESGLWAV	OLFM2	321	O95897
SSMVDGDWTMVDENF	RIC1	1221	Q4ADV7
LEMSTNWGEDMTSVD	ADAMTS19	416	Q8TE59
LDTMAWETILMDTLE	HCFC1	301	P51610
SMELNESSRWTEEEM	NCOR2	606	Q9Y618
MWDQLEDAAMETFSI	MADD	1296	Q8WXG6
LDEMLDWMGNVESSL	DST	4166	Q03001
MEPWAMRALDFADES	HMGN2P46	1	Q86SG4
FDLQWMEVTDMSQED	CCDC88A	171	Q3V6T2
ESLMGEVATDWMDTE	NOTCH3	1711	Q9UM47
EEELTQMVSTMSDGW	KCTD17	151	Q8N5Z5
SEATLMAWSSMDGED	FAM131B	136	Q86XD5
LTALDEETLWEMMES	CARD14	11	Q9BXL6
DEADRMIDSMHQSWL	DDX51	371	Q8N8A6
VTDADSVWMEMDDEE	CASQ1	351	P31415
SVWMEMDDEEDLPSA	CASQ1	356	P31415
EMDMVAWGVDLASVE	DSP	201	P15924
EDLWTVENDMMVSYS	INPP5K	336	Q9BT40
SLQGREWTLMDLDME	HSF4	401	Q9ULV5
EWNDVLSEMTLMDVD	FAM186A	136	A6NE01
DEEMENEICRVWDMS	SAAL1	66	Q96ER3
VWDMSMDEDVALFLQ	SAAL1	76	Q96ER3
LELSAESEAEMAEWM	PLEKHM2	851	Q8IWE5
DMEAMLDTVQAWLSS	NMRK2	61	Q9NPI5
ETTMNEIRWLLEDEM	SZT2	1691	Q5T011
SSDLFEEWMGALEMQ	TAGAP	171	Q8N103
EDWEINKDSAVEMAM	SYNE2	2401	Q8WXH0
MAEDGSEEIMFIWCE	PRDM15	301	P57071
ALSEEDRRLWMEAMD	ARHGAP26	351	Q9UNA1
EEEDAFWMMSAIIED	SGSM3	216	Q96HU1
WTRLDMMDEEEVEVS	SERPINB6	256	P35237
MEDADMTLWTEAEFE	PRDM1	41	O75626
MEEMVEDSVDCYWIT	TBC1D7	141	Q9P0N9
ILAMMVDLQDDEDWV	RANBP6	316	O60518
EEVEMNWDMVQVLSE	SRBD1	206	Q8N5C6
AAEAEAWMSEQELYM	SPTBN1	1601	Q01082
LWDWLIDMESLVMDS	AKAP6	971	Q13023
LMDLNGMSEDALEWD	AKAP6	1206	Q13023
GMSEDALEWDEMDIS	AKAP6	1211	Q13023
EQMESEDMLSALGWS	CIPC	56	Q9C0C6
DVAIDFTQEEWAMMD	ZNF705A	11	Q6ZN79
EEMELSLVMSQRWDS	REV3L	461	O60673
WMDDLGTMISQIEEI	RINT1	141	Q6NUQ1
DVAIDFTQEEWAMMD	ZNF705EP	11	A8MWA4
DVAIDFTQEEWAMMD	ZNF705G	11	A8MUZ8
GIEAAMDWLMEHEDD	UBXN1	31	Q04323
DVAIDFTQEEWDMMD	ZNF705B	11	P0CI00
DVAIDFTQEEWDMMD	ZNF705D	11	P0CH99
EDDEDMTLTRWTGMI	UBE2V2	36	Q15819
LAEMLGDMIWEDLSE	ZW10	326	O43264